1,785 results match your criteria Ocular Lymphoma


Bilateral mantle cell lymphoma of the ciliary body that responded to a combined local radiotherapy and chemotherapy regimen: a case report.

BMC Cancer 2019 Apr 15;19(1):355. Epub 2019 Apr 15.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) that often affects men over the age of 60. Systemic metastasis of MCL to eyes is rare and intraocular involvement is even rarer, which usually affects the choroid and iris. To the best of our knowledge, ciliary body metastasis of systemic MCL has not been reported. Read More

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http://dx.doi.org/10.1186/s12885-019-5530-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466781PMC
April 2019
2 Reads

Intraocular involvement of Mantle cell lymphoma: A case report and literature review.

Hematol Oncol Stem Cell Ther 2019 Apr 6. Epub 2019 Apr 6.

Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL, USA.

Lymphomatous involvement of the ocular adnexal region (OAR) is generally rare; however, it constitutes the most common ocular malignancy. Most cases of ocular adnexal lymphomas are extra nodal marginal zone B cell lymphomas. Mantle cell lymphoma involvement (MCL) of the OAR is a less common presentation compared with other lymphomas and it has been reported anecdotally. Read More

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http://dx.doi.org/10.1016/j.hemonc.2019.03.002DOI Listing
April 2019
1 Read

Interferon Alpha 2a and 2b in Ophthalmology: A Review.

J Interferon Cytokine Res 2019 Apr 5. Epub 2019 Apr 5.

1 Department and Clinic of Ophthalmology, University of Wrocław Medical College, Wrocław, Poland.

Interferon alpha (IFN-α) is a glycoprotein with antitumor, antiviral, and immunomodulatory activity, used widely in the treatment of viral infections (hepatitis B and C, condylomata acuminata, herpes zoster, etc.), hematological disorders (leukemia, multiple myeloma, T cell lymphoma, and essential thrombocythemia), and solid tumors (clear cell carcinoma in the metastatic stage, melanoma, hepatocellular carcinoma, and cervical neoplasia). Studies have proven the effectiveness of IFN-α in the treatment of ophthalmic disorders involving the anterior segment of the eye (conjunctival papilloma, squamous neoplasia, conjunctival mucosa-associated lymphoid tissue, Mooren's ulcer, and vernal keratoconjunctivitis) and the posterior segment of the eye (serpiginous choroidopathy, posterior uveitis, pseudophakic and diabetic cystoid macular edema, and proliferative diabetic retinopathy). Read More

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https://www.liebertpub.com/doi/10.1089/jir.2018.0125
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http://dx.doi.org/10.1089/jir.2018.0125DOI Listing
April 2019
4 Reads

Primary vitreoretinal lymphoma.

Saudi J Ophthalmol 2019 Jan-Mar;33(1):66-80. Epub 2019 Jan 14.

Department of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Primary vitreoretinal lymphoma (PVRL) is a rare ocular lymphoid malignancy, which consists a subset of primary central system lymphoma (PCNSL) and the most common type of intraocular lymphoma. The involvement of eyes is estimated to be approximately 20% of PCNSL, but the brain involvement may be up to 80% of PVRL. Typically, PVRL is a high grade B-cell malignancy of the retina and needs to be assorted from choroidal low-grade B-cell lymphomas. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424706PMC
January 2019
2 Reads

Therapeutic hypothermia protects photoreceptors through activating Cirbp pathway.

Neurochem Int 2019 Jun 14;126:86-95. Epub 2019 Mar 14.

Department of Ophthalmology, Second Hospital of Jilin University, Changchun, PR China. Electronic address:

Therapeutic hypothermia as a physical method to lower the brain temperature of patients has been widely used in clinics as an effective and necessary step during the treatment of acute brain injury or edema. However, due to limitations of the ocular structure, the application of hypothermia in retinal neuroprotection still has an obvious barrier. Here, the neuroprotective mechanism produced by hypothermia in the retina was investigated, with the hopes of deciphering the key molecular targets of the signaling pathway to finally realize the ocular neuroprotection by regulating specific molecular targets. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.03.006DOI Listing
June 2019
1 Read

Primary vitreoretinal lymphoma: prevalence, impact, and management challenges.

Clin Ophthalmol 2019 14;13:353-364. Epub 2019 Feb 14.

Department of Retina and Vitreous, Narayana Nethralaya, Bengaluru - 560010, India,

Primary vitreoretinal lymphoma (PVRL) is a rare and potentially fatal intraocular malignancy. More than half of PVRL cases eventually involve the central nervous system (CNS). PVRL frequently masquerades as chronic uveitis. Read More

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https://www.dovepress.com/primary-vitreoretinal-lymphoma-pre
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http://dx.doi.org/10.2147/OPTH.S159014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387616PMC
February 2019
12 Reads

[Magnetic Resonance Imaging of the Orbital Cavity: Indications and Diagnostic Possibilities].

Klin Monbl Augenheilkd 2019 Mar 18;236(3):321-339. Epub 2019 Feb 18.

Today, magnetic resonance imaging (MRI) is considered the diagnostic tool of choice for eye and orbital pathologies. In this article, the MR image characteristics of relevant pathologies are illustrated with case-based examples in the context of clinical findings. Vascular pathologies (such as capillary and cavernous hemangioma), inflammatory diseases (such as endocrine orbitopathy), and neoplasms (such as lymphoma, uveal melanoma, retinoblastoma, and ocular/orbital metastasis) are described. Read More

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http://dx.doi.org/10.1055/a-0849-0000DOI Listing
March 2019
3 Reads

High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone.

J Diabetes Res 2019 9;2019:2376512. Epub 2019 Jan 9.

Department of Internal Medicine, College of Medicine, Inje University, Busan, Republic of Korea.

Metformin and pioglitazone are two commonly prescribed oral hypoglycemic agents for diabetes. Recent evidence suggests that these drugs may contribute to bladder cancer. This study investigated molecular mechanism underlying effects of metformin and pioglitazone in bladder epithelial carcinogenesis in type 2 diabetes. Read More

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http://dx.doi.org/10.1155/2019/2376512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343135PMC
January 2019
7 Reads

The factors associated with the early diagnosis of nasal NK/T-cell lymphoma with prominent ocular symptoms and general nasal NKTL.

Am J Otolaryngol 2019 Jan 28. Epub 2019 Jan 28.

Department of Nose, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:

Aim: This study explored the clinical features of nasal natural killer/T-cell lymphoma (NKTL) in patients with prominent ocular symptoms and those with general nasal NKTL to improve the early diagnosis of nasal NKTL.

Method: A retrospective cohort study was performed with 278 patients with nasal NKTL admitted to the First Affiliated Hospital of Zhengzhou University between January 2011 and December 2017. Of these cases, 56 presented with nasal NKTL and prominent ocular symptoms, and 222 presented with general nasal NKTL. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.01.012DOI Listing
January 2019
1 Read

Refractory follicular conjunctival lesions: overlook as just inflammation or not?

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

Purpose: To report the clinical manifestations of 199 patients with suspected conjunctival lymphoma, the associations between these features and the pathological diagnoses, and the prognosis of conjunctival lesions during long-term follow-up.

Methods: We conducted a retrospective chart review of 199 patients who underwent conjunctival biopsy on suspicion of conjunctival lymphoproliferative disease between January 2008 and June 2015. We focused on slit-lamp findings in the conjunctiva and the pathological diagnoses. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312836DOI Listing
February 2019
9 Reads

18F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14270

Department of Nuclear Medicine, Lanzhou University Second Hospital, Lanzhou University.

Rationale: Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B cell lymphoma that generally exhibits an indolent clinical course. Currently, the application of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in MALT lymphoma is still controversial. Herein, we reported a case of using F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement. Read More

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http://dx.doi.org/10.1097/MD.0000000000014270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380729PMC
February 2019
14 Reads

Insights from a Case of Vitreoretinal Lymphoma.

Ocul Oncol Pathol 2019 Jan 17;5(1):13-19. Epub 2018 Apr 17.

Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA.

Purpose/background: The aim of this study was to report a patient with vitreoretinal lymphoma with clinical features providing hypothesis-generating insights into the pathophysiology of this disease.

Methods: Clinical history and imaging studies (i.e. Read More

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https://www.karger.com/Article/FullText/487949
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http://dx.doi.org/10.1159/000487949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341330PMC
January 2019
5 Reads

Adult T-Cell Leukemia/Lymphoma-Related Ocular Manifestations: Analysis of the First Large-Scale Nationwide Survey.

Front Microbiol 2018 8;9:3240. Epub 2019 Jan 8.

Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Adult T-cell leukemia/lymphoma (ATL) is a rare and aggressive T-cell malignancy with a high mortality rate, resulting in a lack of information among ophthalmologists. Here, we investigated the state of ophthalmic medical care for ATL and ATL-related ocular manifestations by conducting the first large-scale nationwide survey in Japan. A total of 115 facilities were surveyed, including all university hospitals in Japan that were members of the Japanese Ophthalmological Society and regional core facilities that were members of the Japanese Ocular Inflammation Society. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331419PMC
January 2019
1 Read

Bilateral radiation therapy followed by methotrexate-based chemotherapy for primary vitreoretinal lymphoma.

Am J Hematol 2019 Apr 4;94(4):455-460. Epub 2019 Feb 4.

Department of Medicine, Division of Hematology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.

Primary vitreoretinal lymphoma (PVRL) is a subset of primary CNS lymphoma that presents as isolated ocular disease without brain involvement. Although ocular radiotherapy (RT) is an effective treatment for PVRL, the optimal treatment is uncertain. PVRL may later involve the brain in 56%-85% of patients. Read More

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http://dx.doi.org/10.1002/ajh.25414DOI Listing
April 2019
3 Reads

Ophthalmic manifestations of acute leukaemias.

Cesk Slov Oftalmol Winter 2018;74(3):98-101

Background And Aims: To determine the incidence of ocular pathological findings in a group of patients with acute leukemia. To define the predictive value of the presence of the ocular pathological findings.

Materials And Methods: Retrospective evaluation of a group of 67 patients with acute leukemia (age 1-75 years) examined at the Ophthalmology Clinic, Faculty Hospital Ostrava, from 2005 to 2014. Read More

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http://dx.doi.org/10.31348/2018/1/3-3-2018DOI Listing
April 2019
1 Read

Primary Cutaneous Angiosarcoma of the Eyelid: A Diagnostic and Therapeutic Challenge.

Ocul Oncol Pathol 2018 Jun 12;4(4):230-235. Epub 2018 Jan 12.

Department of Ophthalmic Pathology, Thomas Jefferson University, Philadelphia, PA, USA.

Primary cutaneous angiosarcoma is a rare vasoformative malignant neoplasm that can present a diagnostic and therapeutic challenge. We describe a 76-year-old Caucasian man with right upper eyelid swelling and nodularity, initially suspected clinically to represent either ocular adnexal lymphoma or basal cell carcinoma. Incisional biopsy and wide resection of the mass with frozen section control of margins were interpreted as compatible with hobnail (Dabska-retiform) hemangioendothelioma. Read More

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http://dx.doi.org/10.1159/000485427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322085PMC
June 2018
2 Reads

[Ocular adnexal mantle cell lymphoma: a clinicopathological analysis of nine cases].

Zhonghua Bing Li Xue Za Zhi 2019 Jan;48(1):37-39

Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.01.008DOI Listing
January 2019
2 Reads

A large primary orbital lymphoma with proptosis: A case report and review.

Surg Neurol Int 2018 4;9:249. Epub 2018 Dec 4.

Department of Neurosurgery, Max Superspeciality Hospital, Saket, New Delhi, India.

Background: Primary orbital lymphomas are a rare subset of tumors constituting 1-2% of non-Hodgkin's lymphoma. They are mostly indolent B-cell lymphomas presenting with gradual progressive proptosis, decreased visual acuity, restricted ocular mobility, and diplopia. The role of surgery is mainly for obtaining a biopsy. Read More

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http://dx.doi.org/10.4103/sni.sni_270_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293602PMC
December 2018
1 Read

Case Report: Primary Conjunctival Non-Hodgkin Marginal Zone Lymphoma.

Authors:
Loren W Bennett

Optom Vis Sci 2019 Feb;96(2):133-136

Significance: Ophthalmic manifestations of non-Hodgkin lymphoma are rare, and the diagnosis can be delayed because of nonspecific symptoms and a tendency to mimic the appearance of other ocular diseases. Suspicious presentations will require confirmation of the lymphoma through surgical biopsy.

Purpose: The purpose of this study was to present an isolated conjunctival non-Hodgkin marginal zone lymphoma without systemic involvement, which was successfully managed with external beam radiation. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001337DOI Listing
February 2019
1 Read

Clinical presentation and treatment outcomes of primary ocular adnexal MALT lymphoma in Thailand.

Blood Res 2018 Dec 17;53(4):307-313. Epub 2018 Dec 17.

Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: Primary ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (POML) is the most common subtype of lymphoma involving the eyes in Thailand. We sought to assess the characteristics and treatment outcomes of patients with POML in Thailand.

Methods: We retrospectively reviewed patient data and included patients diagnosed with POML between January 2004 and December 2016 at Chiang Mai University Hospital and King Chulalongkorn Memorial Hospital, Thailand. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.4.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300677PMC
December 2018
12 Reads

Glaucoma secondary to intraocular tumors: mechanisms and management.

Curr Opin Ophthalmol 2019 Mar;30(2):71-81

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose Of Review: Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma.

Recent Findings: Several intraocular tumors can lead to glaucoma, including iris melanoma, iris metastasis, iris lymphoma, trabecular meshwork melanoma, choroidal melanoma, choroidal metastasis, retinoblastoma, and medulloepithelioma. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000550DOI Listing
March 2019
14 Reads

National Study of Ocular Hospitalizations in Medicare Beneficiaries.

Am J Ophthalmol 2019 Mar 13;199:238-245. Epub 2018 Dec 13.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Veterans Affairs Health Services Research and Development Service, Chicago, Illinois, USA. Electronic address:

Purpose: To study the characteristics of Medicare beneficiaries hospitalized for ophthalmic conditions.

Design: Cross-sectional study.

Methods: The 2015 National Medicare 100% Inpatient Limited Dataset was analyzed to identify all patients with either an admitting or primary diagnosis for an ophthalmic condition using ICD-9-CM codes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183067
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http://dx.doi.org/10.1016/j.ajo.2018.12.003DOI Listing
March 2019
12 Reads

The treatment results in patients with lmphoma disease in the orbit.

Cesk Slov Oftalmol Spring 2018;73(5-6):211-217

Introduction: Lymphoma is a malignant disease that can affect several structures of the orbit and eye adnexa. In the area of orbit the non-Hodgkins lymphoma (NHL) is typical, which may be indolent or aggressive. Indolent subtypes include MALT (mucosa-associated lymphoid tissue), follicular lymphoma (FL), lymphoplasmocytic lymphoma (LPL). Read More

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December 2018
3 Reads

Vertical Hyperreflective Lesions on Optical Coherence Tomography in Vitreoretinal Lymphoma.

JAMA Ophthalmol 2018 Nov 29. Epub 2018 Nov 29.

Feinberg School of Medicine, Department of Ophthalmology, Northwestern University, Chicago, Illinois.

Importance: Vitreoretinal lymphoma is a diagnostic challenge and the pathophysiology is still unclear.

Objective: To describe an imaging finding seen on optical coherence tomography (OCT) of patients with vitreoretinal lymphoma.

Design, Setting, And Participants: This case series study was a retrospective medical record review of patients who received a diagnosis of vitreoretinal lymphoma at the Department of Ophthalmology at Northwestern University between July 2014 and January 2016. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.5835DOI Listing
November 2018
16 Reads

IMMUNE RECOVERY UVEITIS-LIKE SYNDROME MIMICKING RECURRENT T-CELL LYMPHOMA AFTER AUTOLOGOUS BONE MARROW TRANSPLANT.

Retin Cases Brief Rep 2018 Nov 26. Epub 2018 Nov 26.

Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Purpose: To report the multimodal imaging findings of immune recovery uveitis mimicking recurrent T-cell lymphoma after autologous bone marrow transplant therapy.

Methods: A 71-year-old man presented with posterior uveitis 6 weeks after chemotherapy and autologous bone marrow transplant for angioimmunoblastic T-cell lymphoma. Multimodal imaging included fluorescein angiography, fundus autofluorescence, and optical coherence tomography. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000829DOI Listing
November 2018
5 Reads

Primary Non-Hodgkin Lymphoma of Sphenoid Sinus Involving Cavernus Sinus and Clivus with Isolated 3rd Nerve Palsy.

Mymensingh Med J 2018 Oct;27(4):888-893

Dr Dhiman Chowdhury, Associate Professor, Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail: dhiman_ns@ yahoo.com.

Lymphomas are group of malignant neoplasm having origins from lymphoreticular cells. B cell Non Hodgkin Lymphoma (BNHL) of sphenoid sinus as primary site for lymphomas are very rare and whenever involves comes usually with ocular manifestations. The proximity of the lesion to optic nerve and cavernous sinus present a high risk of developing unilateral ophthalmoplegia or even blindness. Read More

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October 2018
24 Reads

Gastrointestinal Behcet's-like disease with myelodysplastic neoplasms with trisomy 8: a French case series and literature review.

Leuk Lymphoma 2018 Nov 20:1-7. Epub 2018 Nov 20.

a Department of Internal Medicine Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique-Hôpitaux de Paris , Hôpital Saint-Antoine , Paris , France.

We report the 11 cases of +8-MDS/MPN associated with Behcet's-like syndrome and compare them with Behcet's disease and Crohn's disease, pool with literature cases for analysis. Data for patients with +8-MDS/MPN and Behçet's-like syndrome were collected from MINHEMON. Eleven patients had Behcet's-like syndrome and +8-MDS/MPN (median age 75 years [IQR 65-87]; M/F ratio 0. Read More

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http://dx.doi.org/10.1080/10428194.2018.1542152DOI Listing
November 2018
22 Reads

B-cell lymphoblastic lymphoma of the nictitating membrane as the first presenting sign in a 2-year-old Springer Spaniel.

Clin Case Rep 2018 Nov 12;6(11):2246-2251. Epub 2018 Oct 12.

Department of Pathology, Rigshospitalet University of Copenhagen Copenhagen Denmark.

B-cell lymphoblastic lymphoma is an aggressive malignant disease. Necropsy and microscopical examination revealed widespread disease with a high proliferation index. This is the first reported case of B-cell lymphoblastic lymphoma presenting in the ocular region and only the second reported lymphoma of the nictitating membrane. Read More

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http://dx.doi.org/10.1002/ccr3.1862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230651PMC
November 2018
2 Reads

High Frequency of MYD88 L265P Mutation in Primary Ocular Adnexal Marginal Zone Lymphoma and Its Clinicopathologic Correlation: A Study From a Single Institution.

Arch Pathol Lab Med 2019 Apr 16;143(4):483-493. Epub 2018 Nov 16.

From the Departments of Pathology (Drs Behdad, Gao, and Raparia; Mr Dittman; Drs Qi, Q Chen, and Y-H Chen) and Ophthalmology (Dr Bryar), Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Wayne State University School of Medicine, Detroit, Michigan (Dr Zhou); Research Resources Center, University of Illinois at Chicago, Chicago (Dr Green); Department of Pathology, University of Michigan, Ann Arbor (Dr Betz). Dr Zhou is currently at the Department of Ophthalmology, Bascom-Palmer Eye Institute, Miami, Florida. Dr Raparia is currently at the Department of Pathology, Kaiser Permanente, Santa Clara, California.

Context.—: The pathogenesis of primary ocular adnexal marginal zone lymphoma (POAMZL) remains unclear. The reported associations with Chlamydia psittaci infection and MYD88 mutations are highly variable. Read More

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http://dx.doi.org/10.5858/arpa.2018-0092-OADOI Listing
April 2019
5 Reads

PEDF protects human retinal pigment epithelial cells against oxidative stress via upregulation of UCP2 expression.

Mol Med Rep 2019 Jan 12;19(1):59-74. Epub 2018 Nov 12.

Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Medical University, Ocular Immunology and Inflammation Institute, Shaanxi Provincial Clinical Research Center for Ophthalmology, Xi'an, Shaanxi 710038, P.R. China.

To investigate the protective function of pigment epithelium‑derived factor (PEDF) against oxidative stress (OS) in ARPE‑19 cells, ARPE‑19 cells were divided into different OS groups and treated with various concentrations of H2O2 (0, 75, 150 and 200 µmol/l) for 24 h. To establish the protective group, 200 ng/ml of PEDF was administered to ARPE‑19 cells. Cell Counting Kit‑8 assays and cell growth curve experiments were performed to determine levels of cell viability; lactate dehydrogenase and propidium iodide (PI) staining assays were also performed. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2018.9645
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http://dx.doi.org/10.3892/mmr.2018.9645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297793PMC
January 2019
17 Reads
1.484 Impact Factor

Orbital Lymphoma-An International Multicenter Retrospective Study.

Am J Ophthalmol 2019 Mar 10;199:44-57. Epub 2018 Nov 10.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Purpose: To investigate and characterize the clinical features of subtype-specific orbital lymphoma.

Design: Retrospective, interventional case series.

Methods: The study included 7 international eye cancer centers. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.11.002DOI Listing
March 2019
4 Reads
3.871 Impact Factor

Sjögren's syndrome: state of the art on clinical practice guidelines.

RMD Open 2018 18;4(Suppl 1):e000789. Epub 2018 Oct 18.

Université Paris-Sud: AP-HP, Hôpitaux Universitaires Paris-Sud; INSERM UMR 1184, Le Kremlin Bicêtre, France.

Sjögren's syndrome (SS) is a complex autoimmune rheumatic disease that specifically targets salivary and lachrymal glands. As such, patients typically had ocular and oral dryness and salivary gland swelling. Moreover, skin, nasal and vaginal dryness are frequently present. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203093PMC
October 2018
26 Reads

[Clinical analysis of 42 cases of nasal natural killer/T-cell lymphoma prominently presenting as ocular symptoms].

Authors:
Z Z Hu Y Wang X L Jin

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;32(21):1656-1659

Department of Nose, the First Affiliated Hospital of Zhengzhou University,Zhengzhou, 450052,China.

To investigate the clinical features and prognosis of nasal natural killer/T-cell lymphoma(NKTL) with obvious ocular symptoms.We retrospectively analyzed the clinical data of 42 patients with nasal NKTL who prominently showed eye symptoms and were treated from January 2011 to December 2017.After treatment,the patients received complete remission(CR) in 19 cases and partial remission(PR) in 9 cases. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
Publisher Site
http://dx.doi.org/10.13201/j.issn.1001-1781.2018.21.012DOI Listing
November 2018
3 Reads

T-cell lymphoblastic lymphoma involving the ocular adnexa: report of two cases and review of the current literature.

Orbit 2018 Nov 6:1-7. Epub 2018 Nov 6.

c Florida Eye Specialist , Jacksonville , FL , USA.

The majority of ocular adnexal lymphomas are B-cell in origin. We report two cases of T-cell lymphoblastic lymphoma (T-LBL) involving the ocular adnexa. One patient presented with a painless pink conjunctival lesion and inferior orbital fullness. Read More

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https://www.tandfonline.com/doi/full/10.1080/01676830.2018.1
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http://dx.doi.org/10.1080/01676830.2018.1540013DOI Listing
November 2018
18 Reads

Multicentric lymphoma in a Rottweiler dog with bilateral ocular involvement: A case report.

Vet Res Forum 2018 15;9(3):285-288. Epub 2018 Sep 15.

Department of Clinical Sciences, College of Veterinary Medicine, Karaj Branch, Islamic Azad University, Alborz, Iran.

A 10-year-old, male Rottweilerdog was presented to Small Animal Hospital of Tehran University with a history of lethargy, anorexia, weight loss, vomiting, polyuria, polydipsia and blindness. The dog showed symptoms of depression, high body temperature (39.2 ˚C), tachypnea (40 breaths min) and cachexia. Read More

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http://vrf.iranjournals.ir/article_32090.html
Publisher Site
http://dx.doi.org/10.30466/vrf.2018.32090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198158PMC
September 2018
18 Reads

Paraneoplastic frosted branch angiitis as first sign of relapsed Hodgkin lymphoma.

Clin Case Rep 2018 Oct 29;6(10):1978-1981. Epub 2018 Aug 29.

Division of Ocular Immunology Wilmer Eye Institute Johns Hopkins University Baltimore Maryland.

Frosted branch angiitis (FBA) is a rare form of retinal vasculitis with typical perivascular edema taking the shape of frost on a tree branch. It was reported only twice as the initial presentation of Hodgkin lymphoma (HL). Here, we present the first case of paraneoplastic FBA as the initial sign of HL relapse in an elderly female. Read More

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http://dx.doi.org/10.1002/ccr3.1778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186874PMC
October 2018
16 Reads

Primary vitreoretinal natural killer/T-cell lymphoma with breast involvement: A case report and review of the literature.

Surv Ophthalmol 2019 Mar - Apr;64(2):225-232. Epub 2018 Oct 13.

Department of Ophthalmology, Ruijin Hospital, Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

A 50-year-old woman developed recurrent vitreous opacities in her left eye. The first diagnostic vitrectomy revealed no significant abnormality. Optical coherence tomography showed multiple high-density reflective nodules. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396257183005
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http://dx.doi.org/10.1016/j.survophthal.2018.10.003DOI Listing
February 2019
3 Reads

Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma.

Oncol Rep 2019 Jan 11;41(1):397-404. Epub 2018 Oct 11.

Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.

The aim of the present study was to prospectively evaluate the recurrence and survival outcome of primary central nervous system lymphoma (PCNSL) with intraocular involvement. For this purpose, a prospective cohort of 103 pathologically confirmed patients with PCNSL was enrolled in this study. Ophthalmologic examinations were performed both at diagnosis and during follow‑up. Read More

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http://www.spandidos-publications.com/10.3892/or.2018.6781
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http://dx.doi.org/10.3892/or.2018.6781DOI Listing
January 2019
21 Reads

Choroidal Lymphoma Discovered on Ultrasound in a Patient with Suspected Corneal Tumor.

Ocul Oncol Pathol 2018 Sep 14;4(5):318-321. Epub 2018 Feb 14.

Department of Ophthalmology, University of California, San Francisco, California, USA.

Background/aims: To report the case of a 77-year-old male with a blind, painful eye, referred for suspected corneal mass, with finding of choroidal B-cell lymphoma on pathology of enucleated globe.

Methods: This is a retrospective case report of a single patient.

Results: A 77-year-old male with a longstanding history of poor vision in the left eye was referred for a scarred, vascularized corneal mass. Read More

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https://www.karger.com/Article/FullText/486039
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http://dx.doi.org/10.1159/000486039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167682PMC
September 2018
16 Reads

Dysregulated Marginal Zone B Cell Compartment in a Mouse Model of Sjögren's Syndrome with Ocular Inflammation.

Int J Mol Sci 2018 Oct 11;19(10). Epub 2018 Oct 11.

Department of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.

The risk of developing lymphoma in patients with Sjögren's syndrome (SS) is 44 times higher than in the normal population with the most common lymphomas derived from marginal zone B (MZB) cells. Current understanding of the role of MZB cells in SS is primarily based on salivary gland pathology, while their contextual association with lacrimal glands and ocular manifestations largely remains unknown. We examined this possibility using a SS mouse model (thrombospondin-1 deficient (TSP1)) with well-characterized ocular disease. Read More

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http://dx.doi.org/10.3390/ijms19103117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213455PMC
October 2018
7 Reads

An unusual case report of primary vitreoretinal lymphoma.

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):223. Epub 2018 Sep 14.

Centre for Ophthalmology and Vision Sciences, Faculty of Medical and Human Sciences, Medicine and Health, University of Manchester, Manchester, UK.

Background: Primary vitreoretinal lymphoma (PVRL) is a rare ocular condition and its diagnosis remains a challenge. The clinical presentation is variable and it can masquerade as chronic intermediate or posterior uveitis. We report an unusual case of primary central nervous system lymphoma (PCNSL) presenting as migrating retinal lesions with unique shapes. Read More

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http://dx.doi.org/10.1186/s12886-018-0860-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156902PMC
September 2018
3 Reads

Rare retinal complications of bone marrow transplantation (BMT): a case report.

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):225. Epub 2018 Sep 14.

Leeds Teaching Hospital, Beckett St, Leeds, LS9 7TF, England.

Background: Bone marrow transplantation retinopathy is a rare condition affecting the posterior pole. The purpose of this case report is to highlight the possible risk factors and clinical features.

Case Presentation: A 19y old male with relapsed and refractory acute lymphoblastic leukaemia was admitted under haematology with pyrexia of unknown origin. Read More

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http://dx.doi.org/10.1186/s12886-018-0855-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157125PMC
September 2018
1 Read

Conjunctival chemosis or not?

Indian J Ophthalmol 2018 Oct;66(10):1394

Oculoplasty and Ocular Oncology Services, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

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http://dx.doi.org/10.4103/ijo.IJO_456_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173016PMC
October 2018
2 Reads

Corneal Relapse of Peripheral T-Cell Lymphoma Under Systemic Chemotherapy.

Cornea 2018 Dec;37(12):1593-1595

Department of Pathology, Hacettepe University School of Medicine, Ankara, Turkey.

Purpose: To report a patient who developed unilateral corneal stromal infiltration while undergoing systemic chemotherapy for multinodal peripheral T-cell lymphoma not otherwise specified.

Methods: Clinical, imaging, and immunohistopathological features of a 40-year-old woman who presented with a stromal haze in the right cornea were reviewed.

Results: At initial presentation, her visual acuity in the right eye was 20/40. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001759DOI Listing
December 2018

Cancers of the eye.

Cancer Metastasis Rev 2018 12;37(4):677-690

The New York Eye Cancer Center, Suite 5B, 115 East 61st Street, New York, NY, 10065, USA.

Ocular cancers are unique among the diseases of the eye, threatening both vision and life. In most cases, the diagnosis can be made utilizing a careful clinical history and specialized ocular examination. Eye cancer diagnosis relies heavily on imaging techniques such as high-frequency ultrasound, fluorescein angiography, anterior and posterior segment optical coherence tomography, computed tomography (CT), and magnetic resonance imaging (MRI). Read More

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http://link.springer.com/10.1007/s10555-018-9762-9
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http://dx.doi.org/10.1007/s10555-018-9762-9DOI Listing
December 2018
25 Reads

Case 01-2017 - Primary vitreoretinal lymphoma (PVRL): report of a case and update of literature from 1942 to 2016.

Ann Eye Sci 2017 Jul 1;2. Epub 2017 Jul 1.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Primary vitreoretinal lymphoma (PVRL), as a subset of primary central nervous system lymphoma (PCNSL), is a rare and fatal ocular malignancy. Most PVRL masquerades as chronic posterior uveitis, which makes the clinical diagnosis challenging. Vitreous cells, subretinal lesions and imaging techniques are essential for clinical diagnosis. Read More

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http://aes.amegroups.com/article/view/3748/4508
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http://dx.doi.org/10.21037/aes.2017.06.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112824PMC
July 2017
14 Reads