1,916 results match your criteria Ocular Lymphoma


Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway.

Biomed Pharmacother 2020 May 24;128:110273. Epub 2020 May 24.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, No.7 Jinsui Road, Tianhe District, Guangzhou City, China. Electronic address:

Ocular inflammation is a common pathological condition of a series of retinal degenerative diseases. Tetramethylpyrazine (TMP), a Chinese herbal extraction, is widely used in the treatment of several ocular diseases in Eastern countries. However, the exact mechanisms correlating the vision protective effects of TMP have not been elucidated. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110273DOI Listing

Primary Vitreoretinal Lymphoma in HIV Infection.

Ocul Immunol Inflamm 2020 May 26:1-7. Epub 2020 May 26.

Eye and Vision Health, Flinders University, Adelaide, Australia.

: To describe the epidemiology, clinical characteristics, diagnosis and treatment of human immunodeficiency virus (HIV)-related primary vitreoretinal lymphoma (PVRL).: Narrative literature review.: HIV-related PVRL occurs in persons who are relatively young and generally have very low CD4+ T-cell counts. Read More

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http://dx.doi.org/10.1080/09273948.2020.1751856DOI Listing

ASSOCIATION OF VITREORETINAL LYMPHOMA WITH SYSTEMIC LYMPHOMA.

Retina 2020 May 19. Epub 2020 May 19.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Dr. Dalvin is now with the Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.

Purpose: To determine the association between vitreoretinal lymphoma and systemic lymphoma (SL).

Methods: Single-center retrospective review of medical records.

Results: Of 95 patients with vitreoretinal lymphoma, 18 (19%) had associated SL (SL group) and 77 (81%) were not associated with SL (no SL group). Read More

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http://dx.doi.org/10.1097/IAE.0000000000002855DOI Listing

Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review.

Ophthalmic Plast Reconstr Surg 2020 May 15. Epub 2020 May 15.

Pathology Service, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: To describe a patient with orbital adult T-cell leukemia/lymphoma (ATLL) and to review the literature on presentation, diagnostics, management, and clinical course of this rare disease.

Methods: A systematic literature review. PubMed/MEDLINE and Google Scholar databases were searched for all well-documented cases of orbital/ocular adnexal ATLL. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001695DOI Listing

Ocular adnexal lymphoma presenting as incidental tarsal follicles.

Am J Ophthalmol Case Rep 2020 Sep 4;19:100731. Epub 2020 May 4.

Department of Ophthalmology and Visual Science, Yale University School of Medicine, 40 Temple Street, New Haven, CT, USA.

Purpose: To report a case of ocular adnexal lymphoma presenting as asymptomatic follicles discovered incidentally on routine examination.

Observations: A 43-year-old woman presented for routine annual examination and was incidentally found to have unilateral giant follicles in the left eye inferior fornix. She denied any ocular or systemic symptoms. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225618PMC
September 2020

Impact of Marital Status on Survival in Patients with Ocular and Periocular Malignancies: A Retrospective Analysis of 3159 Patients from the SEER Database.

Clin Ophthalmol 2020 23;14:1127-1133. Epub 2020 Apr 23.

Department of Ophthalmology,Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA.

Background: An ocular or periocular malignancy can profoundly impact patients' lives as they cope with the challenges of a potentially life-threatening diagnosis and the exhaustive treatment process it entails. An amalgam of biopsychosocial factors can influence prognosis. This study aims to determine whether marital status impacts the long-term survival of patients with these malignancies. Read More

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http://dx.doi.org/10.2147/OPTH.S238034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186878PMC

Extra-Nodal Marginal Zone Lymphoma (MZL) of MALT CD20+ of the Ocular Adnexa: Case Report.

Maedica (Buchar) 2020 Mar;15(1):126-128

Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia.

Even though rare in the orbital region, lymphomas are reported as the third most common malignancies of the conjunctiva, following squamous cell carcinoma and melanoma. It is estimated that more than 95% lymphomas in periocular tissues are B cell in origin. We present a case of extra-nodal marginal zone lymphoma (MZL) of MALT type of the ocular adnexa, successfully treated with chemoimmunotherapy R-CVP. Read More

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http://dx.doi.org/10.26574/maedica.2020.15.1.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221267PMC

Ophthalmic involvement of chronic lymphocytic leukemia: a systematic review of 123 cases.

Surv Ophthalmol 2020 May 11. Epub 2020 May 11.

Service de Médecine Interne, Centre de Référence Maladies systémiques auto-immunes rares d'Ile de France, Hôpital Cochin, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France;. Electronic address:

In order to identify clinical presentations, main causes and prognosis of ophthalmic involvement in chronic lymphocytic leukemia (CLL), we performed a systematic review of articles describing CLL ophthalmic involvement in January 2019, using the Pubmed database. We found 86 articles describing 123 cases of patients with ophthalmic involvement associated with CLL. Ophthalmic symptoms were CLL's first manifestation in 25. Read More

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http://dx.doi.org/10.1016/j.survophthal.2020.05.001DOI Listing

Reduced frequency of Intravitreal methotrexate injection lowers the risk of Keratopathy in Vitreoretinal lymphoma patients.

BMC Ophthalmol 2020 May 12;20(1):189. Epub 2020 May 12.

Department of Ophthalmology, Huashan Hospital North, Fudan University, Shanghai, China.

Background: Intravitreal methotrexate has been proven to be an effective treatment method for vitreoretinal lymphoma. However, keratopathy occurs as the major side effect during treatment in most cases. The purpose of this study is to describe the characteristics of primary central nervous system lymphoma (PCNSL) with intraocular involvement and to attempt to reduce the incidence of keratopathy caused by intravitreal methotrexate. Read More

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http://dx.doi.org/10.1186/s12886-020-01464-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216350PMC

Pathological Findings in Koala Retrovirus-positive Koalas (Phascolarctos cinereus) from Northern and Southern Australia.

J Comp Pathol 2020 Apr 12;176:50-66. Epub 2020 Mar 12.

School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.

Koala retrovirus (KoRV) infection shows differences in prevalence and load between northern and southern Australian koala populations; however, the effect of this on diseases such as lymphoma and chlamydial disease is unclear. This study compared clinicopathological findings, haematology and splenic lymphoid area of KoRV-positive koalas from northern (Queensland [Qld], n = 67) and southern (South Australia [SA], n = 92) populations in order to provide further insight into KoRV pathogenesis. Blood was collected for routine haematology and for measurement of KoRV proviral load by quantitative polymerase chain reaction (qPCR). Read More

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http://dx.doi.org/10.1016/j.jcpa.2020.02.003DOI Listing

SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FEATURES OF VITREORETINAL LYMPHOMA IN 55 EYES.

Retina 2020 Apr 28. Epub 2020 Apr 28.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: To evaluate spectral domain optical coherence tomography (SD-OCT) features of vitreoretinal lymphoma (VRL).

Methods: Review of records and SD-OCT images of vitreoretinal lymphoma evaluated at Ocular Oncology Service, Wills Eye Hospital between July 1, 2000, and April 1, 2019.

Results: There were 55 eyes of 32 patients included. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002819DOI Listing

Mutations in Primary Marginal Zone Lymphomas of Ocular Adnexa are associated with unique morphometric phenotypes.

Curr Eye Res 2020 Apr 27. Epub 2020 Apr 27.

Department of Pathology Stanford University, Stanford CA 94305, USA.

Extranodal marginal zone B-cell lymphoma (EMZL) of mucosa associated lymphoid tissue (MALT) that affect the ocular adnexa, also known as ocular adnexal MALT lymphomas (OAML), are low grade lymphomas that mostly affect elderly individuals. This study was conducted to explore the genetic and microbial drivers of OMAL, and unique morphometric phenotypes associated with these mutations and infections. In this study we performed targeted deep sequencing of 8 OAML cases to identify its potential genetic and microbial drivers. Read More

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http://dx.doi.org/10.1080/02713683.2020.1762228DOI Listing

To What Extent Can Orbital Cellulitis Emergency Aspect Influence the Diagnosis of Maxillary Sinus Lymphoma?

Case Rep Ophthalmol Med 2020 8;2020:2304861. Epub 2020 Apr 8.

Ophthalmology Department, Military Instruction Hospital Mohammed V, Rabat, Morocco.

We present a case of a 46-year-old woman admitted to the emergency department for acute swelling and erythema of the right eyelid for 3 days. Ophthalmological examination was notable for 10/10, P2 best visual acuity, and inflammatory periorbital edema, without exophthalmia nor extraocular motility disturbance. Intraocular pressure was 14 mmHg and fundoscopic examination was not notable for any abnormality. Read More

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http://dx.doi.org/10.1155/2020/2304861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168696PMC

Prognostic factors for relapse and survival among patients with ocular adnexal lymphoma: validation of the eighth edition of the American Joint Committee on Cancer (AJCC) TNM classification.

Br J Ophthalmol 2020 Apr 23. Epub 2020 Apr 23.

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Background/aims: To validate the prognostic performance of the American Joint Committee on Cancer (AJCC) eighth edition classification for ocular adnexal lymphoma (OAL).

Methods: We performed a retrospective review of 140 consecutive patients treated for primary OAL between March 2010 and September 2017. Associations between T/N/M categories at presentation and disease-related outcomes, including relapse, progression-free survival (PFS) and overall survival (OS) were evaluated. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315875DOI Listing

Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing.

Cancers (Basel) 2020 Apr 17;12(4). Epub 2020 Apr 17.

Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.

The pathogenesis of ocular adnexal marginal zone lymphomas of mucosa-associated lymphatic tissue-type (OAML) is not fully understood. We performed whole genome sequencing (WGS) and/or whole exome sequencing (WES) for 13 cases of OAML and sequenced 38 genes selected from this analysis in a large cohort of 82 OAML. Besides confirmation of frequent mutations in the genes transducin beta like 1 X-linked receptor 1 () and cAMP response element binding protein (), we newly identifed as a frequently mutated gene in OAML (11% of cases). Read More

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http://dx.doi.org/10.3390/cancers12040986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225979PMC

Neuro-Ophthalmic Manifestations of Intracranial Malignancies.

J Neuroophthalmol 2020 Apr 6. Epub 2020 Apr 6.

Department of Ophthalmology (CRD, AGL), Cullen Eye Institute, Baylor College of Medicine, Houston, Texas; Blanton Eye Institute (ATK, BAAO, AGL), Houston Methodist Hospital, Houston, Texas; and Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medicine, New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; Department of Ophthalmology (AGL), UT MD Anderson Cancer Center, Houston, Texas; Department of Ophthalmology (AGL), Texas A and M College of Medicine, College Station, Texas; Department of Ophthalmology (AGL), University of Iowa Hospitals and Clinics, Iowa City, Iowa; Department of Ophthalmology (AGL), University of Buffalo, Buffalo, New York.

Background: To describe the various neuro-ophthalmic presentations, key exam features, and clinical findings associated with 5 common primary and secondary intracranial malignancies.

Evidence Acquisition: Retrospective PubMed search and review of published case reports, case series, observational studies, book chapters, and review articles examining the neuro-ophthalmic features of intracranial malignancies including primary glial neoplasms (e.g. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000950DOI Listing

Orbital Mucosa-Associated Lymphoid Tissue Lymphoma and Primary Cutaneous Classical Hodgkin Lymphoma: A Rare Case Report and Review of the Literature.

Case Rep Hematol 2020 28;2020:1945058. Epub 2020 Mar 28.

Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, USA.

A 60-year-old woman was diagnosed with isolated mucosa-associated lymphoid tissue (MALT) lymphoma of the ocular adnexa and treated with two years of weekly rituximab for eight doses followed by rituximab maintenance. After nearly two years of maintenance therapy, she developed a tender, indurated mass on the left neck. Biopsy results were consistent with primary cutaneous classical Hodgkin lymphoma (PCCHL). Read More

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http://dx.doi.org/10.1155/2020/1945058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142340PMC

Alteration of Cell Surface Markers CD38 and CD138 in Lymphoproliferative Disorders in the Ocular Adnexa.

Anticancer Res 2020 Apr;40(4):2019-2023

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Background/aim: CD38 is a cell surface marker commonly present in plasma cells and activated T cells, while CD138 is a representative plasma cell marker. The aim of this study was to describe the expression of cell surface markers including CD38 and CD138, in the tumors of patients with IgG4-related ophthalmic disease (IgG4-ROD) and extranodal marginal zone B-cell lymphoma (EMZL) of the ocular adnexa.

Materials And Methods: Twenty-four consecutive patients of whom 12 had IgG4-ROD and 12 EMZL were enrolled in this study. Read More

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http://dx.doi.org/10.21873/anticanres.14158DOI Listing

HTLV-1 in Ophthalmology.

Authors:
Koju Kamoi

Front Microbiol 2020 11;11:388. Epub 2020 Mar 11.

Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus described as a causative agent for human disease. In the field of ophthalmology, a close relationship between HTLV-1 infection and uveitis was identified through a series of clinical and laboratory studies in the late 1980s-1990s. Since then, HTLV-1-related ocular manifestations such as keratoconjunctivitis sicca, interstitial keratitis, optic neuritis and adult T-cell leukemia/lymphoma (ATL)-related ocular manifestations have continuously been reported. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078647PMC

Bilateral serous retinal detachments associated with burkitt lymphoma.

Am J Ophthalmol Case Rep 2020 Jun 7;18:100654. Epub 2020 Mar 7.

Department of Ophthalmology & Visual Sciences, Montefiore Medical Center/AECOM, Bronx, NY, USA.

Purpose: To report a case of bilateral serous retinal detachments in a patient found to have burkitt lymphoma.

Observations: A patient who presented with bilateral serous retinal detachments and "B" symptoms underwent extensive workup and was found to have burkitt lymphoma. Multiagent chemotherapy was initiated with resolution of the serous retinal detachments and visual recovery occurring in parallel to disease remission. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078497PMC

Extranodal Ocular Adnexal Marginal Zone Lymphoma in a Ten-Year-Old Child

Turk J Ophthalmol 2020 Mar;50(1):53-55

Ege University Faculty of Medicine, Department of Patalogy, İzmir, Turkey

A 10-year-old girl was brought to the clinic with the complaint of a salmon-colored conjunctival lesion for 1 month. With the aid of histopathological evaluation and other tests, extranodal ocular adnexal marginal zone lymphoma was diagnosed. The patient was graded as T1bN0M0 according to AJCC and Stage 1 according to Ann Arbor classification. Read More

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http://dx.doi.org/10.4274/tjo.galenos.2019.62592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086099PMC

Pseudo-inflammatory manifestations of choroidal lymphoma resembling Vogt-Koyanagi-Harada disease: case report based on multimodal imaging.

BMC Ophthalmol 2020 Mar 10;20(1):94. Epub 2020 Mar 10.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Background: Hematologic malignancies occasionally cause serous retinal detachment (SRD); however, its pathogenesis remains unclear. Here we present the imaging characteristics of metastatic choroidal lymphoma masquerading as Vogt-Koyanagi-Harada (VKH) disease.

Case Presentation: A 45-year-old Japanese woman was referred to our clinic because of bilateral SRD with blurred vision. Read More

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http://dx.doi.org/10.1186/s12886-020-01353-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065374PMC

[Primary leptomeningeal lymphoma with oculomotor paralysis as the initial presentation].

Rinsho Ketsueki 2020 ;61(2):116-121

Department of Diagnostic Pathology, Asahi General Hospital.

An 85-year-old man presented with right eye ptosis and visual abnormalities. Due to a lack of abnormal findings on plain magnetic resonance imaging (MRI) and laboratory examination, prednisolone therapy was initiated, and ocular myasthenia gravis and ocular symptoms subjectively improved. However, anorexia and conscious disorder appeared during the same period, and he was hospitalized for scrutiny. Read More

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http://dx.doi.org/10.11406/rinketsu.61.116DOI Listing

Hepatitis C virus in MALT-lymphoma of the ocular adnexa.

Pathol Res Pract 2020 Apr 20;216(4):152864. Epub 2020 Feb 20.

Department of Advanced Biomedical Sciences, Pathology Section, Federico II University of Naples, Naples, Italy. Electronic address:

Objective: Hepatitis C virus (HCV) has been proposed as a possible etiologic factor in ocular adnexal marginal zone lymphoma (OAML). We aimed to assess the prevalence of HCV infection in patients with OAML through a systematic review and meta-analysis.

Methods: Electronic databases were searched from their inception to August 2019 for studies assessing HCV seroprevalence in patients with OAML. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152864DOI Listing

Mantle Cell Lymphoma of Mucosa-Associated Lymphoid Tissue: A European Mantle Cell Lymphoma Network Study.

Hemasphere 2020 Feb 16;4(1):e302. Epub 2019 Dec 16.

Division of Hematology, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.

While classical nodal mantle cell lymphoma (cMCL) is often associated with involvement of multiple extranodal sites, isolated extranodal disease (ED) at the time of diagnosis is a rare event; data on the outcome of these forms are lacking. On behalf of the European MCL Network, we conducted a retrospective analysis on the clinical characteristics and outcomes of MCL presenting with isolated or predominant ED (MALT MCL). We collected data on 127 patients with MALT MCL diagnosed from 1998 to 2015: 78 patients (61%) were male with a median age of 65 years. Read More

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http://dx.doi.org/10.1097/HS9.0000000000000302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000480PMC
February 2020

Changes in Etiology of Uveitis in a Single Center in Japan.

Ocul Immunol Inflamm 2020 Feb 18:1-6. Epub 2020 Feb 18.

Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

: We investigated the changes in etiology of uveitis at the Uveitis Clinic of Tokyo Medical University Hospital in recent years.: Medical records of patients with uveitis diagnosed between 2011 and 2017 (Group A) and between 2001 and 2007 (Group B) were reviewed.: 1,587 patients in group A and 1,507 patients in group B were analyzed. Read More

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http://dx.doi.org/10.1080/09273948.2019.1709649DOI Listing
February 2020

Eye involvement in primary central nervous system lymphoma.

Surv Ophthalmol 2020 Feb 11. Epub 2020 Feb 11.

College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia. Electronic address:

Primary central nervous system lymphoma (PCNSL) may manifest initially in the eye (termed vitreoretinal lymphoma or VRL) or in non-ocular CNS compartments, or in both. The nature of the onset of PCNSL implies two clinical specialists - ophthalmologists and neuro-oncologists - independently may assess the primary presentation of this rare malignancy. Clinically relevant perspectives on expectations of PCNSL manifestation in both ocular and non-ocular CNS compartments would help inform management practices in each specialty, which should impact clinical outcomes. Read More

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http://dx.doi.org/10.1016/j.survophthal.2020.02.001DOI Listing
February 2020

High throughput sequencing reveals high specificity of TNFAIP3 mutations in ocular adnexal marginal zone B-cell lymphomas.

Hematol Oncol 2020 Feb 3. Epub 2020 Feb 3.

Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.

The majority of ocular adnexal (OA) lymphomas (OAL) are extranodal marginal zone lymphomas (MZL). First high throughput sequencing (HTS) studies on OA-MZL showed inconsistent results and the distribution of mutations in reactive lymphoid lesions of this anatomic region has not yet been sufficiently addressed. We characterized OAL and lymphoid lesions of the OA by targeted HTS. Read More

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http://dx.doi.org/10.1002/hon.2718DOI Listing
February 2020

The role of infectious agents in cancer of the ocular region.

APMIS 2020 Feb 30;128(2):136-149. Epub 2020 Jan 30.

Eye Pathology Section, Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

The purpose of the study was to investigate the association between infectious agents and the development of cancer in the ocular adnexa. A comprehensive literary study was carried out, reviewing and summarizing previous reports on the topic. A broad range of malignancies of the ocular adnexa are associated with infectious agents. Read More

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http://dx.doi.org/10.1111/apm.13017DOI Listing
February 2020

Concomitant Orbital Tumours: Small Lymphocytic Lymphoma Involving the Lacrimal Gland of a Patient with Clinical Diagnoses of Muir-Torre Syndrome and Extensive Sebaceous Gland Carcinoma of the Ipsilateral Eyelid.

Ocul Oncol Pathol 2020 Jan 5;6(1):15-19. Epub 2019 Jun 5.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom.

Background/aims: We present a case of 2 concomitant tumours, i.e., a sebaceous carcinoma (SC) and a small lymphocytic lymphoma (SLL), in the lacrimal gland of a patient with Muir-Torre syndrome

Methods: Clinical history, orbital examination, diagnostic biopsy, excisional biopsy, and histopathologic analysis were utilized. Read More

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http://dx.doi.org/10.1159/000500161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984142PMC
January 2020

Radiotherapy alone for stage IE ocular adnexal mucosa-associated lymphoid tissue lymphomas: long-term results.

Radiat Oncol 2020 Jan 30;15(1):25. Epub 2020 Jan 30.

Department of Radiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.

Background: To evaluate the long-term efficacy and toxicity of radiation therapy in patients with Stage IE primary ocular adnexal mucosa-associated lymphoid tissue lymphoma.

Methods: We designed a retrospective analysis to evaluate 81 patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiation therapy between 2006 and 2016. The median radiation dose was 30 Gy (range, 30-36 Gy in 15-18 fractions). Read More

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http://dx.doi.org/10.1186/s13014-020-1477-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993363PMC
January 2020

Survival and ocular preservation in a long-term cohort of Japanese patients with retinoblastoma.

BMC Pediatr 2020 Jan 28;20(1):37. Epub 2020 Jan 28.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Retinoblastoma is an ocular tumor in infants with cancer predisposition. Treatment of the rare tumor needs to be optimized for ocular preserved survival without second primary malignancy (SPM).

Methods: We studied the outcomes of all patients with retinoblastoma at a tertiary center in 1984-2016, when preservation method changed from radiotherapy (1984-2001) to systemic chemotherapy (2002-2016). Read More

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http://dx.doi.org/10.1186/s12887-020-1923-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986142PMC
January 2020

HISTOLOGIC FINDINGS IN VITREORETINAL LYMPHOMA: Learning From Enucleation Specimens.

Retina 2020 02;40(2):391-398

Departments of Laboratory Medicine and Pathology.

Purpose: We aimed to describe the clinical and histologic findings in a few enucleation cases with intraocular lymphoma.

Methods: Retrospective review of pathology files from a 22-year period identified cases with intraocular lymphoma among all enucleation specimens. Patient demographics, clinical findings, laboratory results, radiographic studies, and indication for enucleation were abstracted from electronic health records; slides were reviewed. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002676DOI Listing
February 2020

Effects of radiation therapy on the meibomian glands and dry eye in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma.

BMC Ophthalmol 2020 Jan 13;20(1):24. Epub 2020 Jan 13.

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea.

Background: Radiation therapy (RT) is the treatment of choice in patients with low-grade ocular adenexal mucosa-associated lymphoid tissue lymphoma (OAML) and many of them experience post-RT dry eye with varying severity. The purpose of the present study was to investigate ocular effects of RT on meibomian glands and dry eye by directly visualizing structural changes. Secondly, we focused on the comparison of two groups of patients according to tumor location and radiation technique. Read More

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http://dx.doi.org/10.1186/s12886-019-1301-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958586PMC
January 2020

Clinical Features Predictive of Survival in Patients With Vitreoretinal Lymphoma: Analysis of 70 Patients at a Single Ocular Oncology Center.

Asia Pac J Ophthalmol (Phila) 2020 Mar-Apr;9(2):110-116

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA.

Purpose: The aim of this study was to identify clinical factors predictive of time to central nervous system (CNS) lymphoma or death in patients with vitreoretinal lymphoma (VRL).

Design: Retrospective cohort study.

Methods: Patients with VRL (n = 95 patients) from Januray 1, 1984 to July 30, 2018 were identified at a single ocular oncology center and records were retrospectively reviewed. Read More

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http://dx.doi.org/10.1097/APO.0000000000000274DOI Listing
January 2020

Cytopathology and Polymerase Chain Reaction of Vitreous Fluid in Tubercular Intermediate Uveitis.

Ocul Immunol Inflamm 2020 Jan 6:1-3. Epub 2020 Jan 6.

Department of Uveitis and Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

: Cytopathology of vitreous is most commonly done to diagnose vitreoretinal lymphoma in eyes with nonspecific inflammation. Vitreous cytopathology features of tuberculous intermediate uveitis have not been described in literature.: We report a case of a healthy 35-year-old female who showed granulomatous inflammatory changes on vitreous cytopathology with polymerase chain reaction confirming a diagnosis of intraocular tuberculosis. Read More

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http://dx.doi.org/10.1080/09273948.2019.1697825DOI Listing
January 2020

CHOROIDAL NEOVASCULAR MEMBRANE AFTER FINE-NEEDLE ASPIRATION BIOPSY OF VITREORETINAL LYMPHOMA.

Retin Cases Brief Rep 2019 Dec 27. Epub 2019 Dec 27.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: To report development of choroidal neovascular membrane at the site of diagnostic transvitreal fine-needle aspiration biopsy of subretinal pigment epithelial infiltrates in an eye with vitreoretinal lymphoma.

Methods: Case report. A 75-year-old white woman with 14-month history of bilateral vitritis. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000933DOI Listing
December 2019

Conjunctival Pediatric Follicular Lymphoma: Case Report and Literature Review.

Ophthalmic Plast Reconstr Surg 2020 Jan/Feb;36(1):e14-e15

King Khaled Eye Specialist Hospital.

Follicular lymphoma (FL) is the second most commonly reported B-cell lymphoma and accounts for 6% of all orbital lymphomas. FL presentation in the pediatric population is rare. This study reported an 18-year-old male with a pink elevated lesion in the conjunctiva of the left eye and normal ocular parameters. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001500DOI Listing
December 2019

Conjunctival Pediatric-Type Follicular Lymphoma.

Ophthalmic Plast Reconstr Surg 2020 Mar/Apr;36(2):e46-e49

Pathology Service, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.

Pediatric-type follicular lymphoma is an uncommon B-cell lymphoma that primarily involves the lymph nodes of the head and neck of children and young adults. Ocular involvement is rare, with only 5 well-documented cases in the literature, all occurring in the conjunctiva. The authors describe a 20-year-old African American man with enlarging bilateral medial conjunctival nodules. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001556DOI Listing
December 2019

Czech and Slovak Diamond-Blackfan Anemia (DBA) Registry update: Clinical data and novel causative genetic lesions.

Blood Cells Mol Dis 2020 03 11;81:102380. Epub 2019 Nov 11.

Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, I. P. Pavlova 6, 77900 Olomouc, Czech Republic. Electronic address:

Diamond-Blackfan anemia (DBA) is a rare congenital erythroid aplasia, underlied by haploinsufficient mutations in genes coding for ribosomal proteins (RP) in approximately 70% of cases. DBA is frequently associated with somatic malformations, endocrine dysfunction and with an increased predisposition to cancer. Here we present clinical and genetic characteristics of 62 patients from 52 families enrolled in the Czech and Slovak DBA Registry. Read More

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http://dx.doi.org/10.1016/j.bcmd.2019.102380DOI Listing

Sjögren's syndrome: Old and new therapeutic targets.

J Autoimmun 2020 Jun 9;110:102364. Epub 2019 Dec 9.

Academy of Athens, Chair Medical Sciences/Immunology, Greece.

Sjögren's syndrome (SS) is a prototype autoimmune disease characterized by oral and ocular mucosal dryness following chronic inflammation of salivary and lachrymal glands, respectively. Profound B cell hyperactivity along with systemic manifestations including fatigue, musculoskeletal complaints, features related to hepatic, pulmonary, renal and nervous system involvement, as well as lymphoma development can be also present. Despite that activation of both innate and adaptive immune pathways has been long well documented in SS pathogenesis, systemic immunosuppression in SS, in contrast to other autoimmune diseases, has been largely inefficacious. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.102364DOI Listing
June 2020
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[Ocular lymphoma : Precise diagnostics and classification as key for successful personalized treatment].

Ophthalmologe 2019 Dec 6. Epub 2019 Dec 6.

Zentrum für Augenheilkunde, Universitätsklinikum zu Köln, Köln, Deutschland.

Background: Personalized medicine is nowadays the standard of care for patients with oncological diseases. A prime example is the lymphoma, which has substantial points of contact with ophthalmological care due to the intraocular and periocular involvement.

Objective: This article provides a description of the current personalized diagnostics and treatment of ocular lymphomas. Read More

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http://dx.doi.org/10.1007/s00347-019-01020-5DOI Listing
December 2019

A rare case of non-small cell lung cancer choroidal metastasis responding to ALK tyrosine kinase inhibitors.

Anticancer Drugs 2020 01;31(1):90-94

Radiation Oncology Unit.

Choroidal localization from non-small cell lung cancer is rare and when it occurs may cause visual alterations. Targeted therapy against actionable gene mutations represents the standard of care in advanced non-small cell lung cancer. We report the case of a 53-year-old woman affected by metastatic anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer who received ALK tyrosine kinase inhibitors, from January 2017. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000848DOI Listing
January 2020

MULTIPLE RETINAL PIGMENT EPITHELIUM APERTURES ASSOCIATED WITH PSEUDO-VITELLIFORM LYMPHOMATOUS MACULOPATHY.

Retin Cases Brief Rep 2019 Nov 28. Epub 2019 Nov 28.

Ocular Immunology and Uveitis Service, Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy.

Purpose: To describe the case of a 66-year-old man with bilateral cytologically proven vitreoretinal lymphoma who presented with a pseudo-vitelliform macular lesion and multiple retinal pigment epithelium apertures.

Methods: The patient underwent comprehensive ophthalmologic evaluation, including best-corrected visual acuity, intraocular pressure, anterior segment and fundus examination, and optical coherence tomography, at baseline and during follow-up.

Results: A new-onset foveal yellow, ill-defined lesion was noticed in the right eye during the follow-up; best-corrected visual acuity was 20/20, and the patient was asymptomatic. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000952DOI Listing
November 2019

Masqueraders of multiple evanescent white dot syndrome (MEWDS).

Int Ophthalmol 2020 Mar 2;40(3):627-638. Epub 2019 Dec 2.

Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Purpose: To describe disorders that can masquerade as multiple evanescent white dot syndrome (MEWDS).

Design: Retrospective, multicenter case series.

Participants: Patients who presented with clinical findings compatible with a diagnosis of MEWDS but were ultimately diagnosed with an alternative inflammatory, infectious, or neoplastic disorder. Read More

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http://dx.doi.org/10.1007/s10792-019-01223-4DOI Listing

Understanding and Classification of Ocular Lymphomas.

Authors:
Valerie A White

Ocul Oncol Pathol 2019 Oct 16;5(6):379-386. Epub 2019 May 16.

WHO/IARC Classification of Tumours Group, International Agency for Research on Cancer, Lyon, France.

Background: Lymphomas that involve the tissues of the ocular adnexae and the eye itself can be confusing for both the new and seasoned learner alike. In this review, I present a simple way of classifying these disorders that will help to facilitate understanding of these myriad entities.

Summary: Classifications of lymphomas have changed significantly over the last 40 years, but in recent decades, the basic structure of the WHO classification has remained the same, facilitating understanding. Read More

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http://dx.doi.org/10.1159/000499845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872993PMC
October 2019

Lymphoma and unilateral diffuse uveal melanocytic proliferation: when both conditions co-exist in the eye.

Arch Soc Esp Oftalmol 2020 Feb 22;95(2):98-102. Epub 2019 Nov 22.

Hospital Campo Arañuelo, Navalmoral de la Mata, Cáceres, España.

The case is presented of a 60 year-old male with decreased visual acuity in his left eye (LE). In the funduscopic examination, pigmentary alterations associated with sub-retinal orange plaques could be observed that, in autofluorescence, manifested as hypoautofluorescent spots. Subsequently, the patient subsequently developed significant vitritis with large white sub-retinal plaques on the posterior pole of his LE, with no alterations in the right eye. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.10.002DOI Listing
February 2020

Lifitegrast ophthalmic solution for treatment of ocular chronic graft-versus-host disease.

Leuk Lymphoma 2020 Apr 25;61(4):869-874. Epub 2019 Nov 25.

Division of Hematology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.

Ocular chronic graft-versus-host disease (oGVHD) is a relatively common complication that occurs following allogeneic hematopoietic cell transplantation. Keratoconjunctivitis sicca (KCS) is the most common manifestation of oGVHD. Lifitegrast is a lymphocyte function-associated antigen-1 antagonist approved to reduce inflammation and symptoms in patients with dry eye disease. Read More

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http://dx.doi.org/10.1080/10428194.2019.1695049DOI Listing

Ultra-low-dose (boom-boom) radiotherapy for choroidal lymphoma in three consecutive cases.

Eur J Ophthalmol 2019 Nov 24:1120672119888985. Epub 2019 Nov 24.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To describe the outcome of ultra-low-dose (boom-boom) radiotherapy for choroidal lymphoma.

Methods: Retrospective series of three consecutive patients with biopsy-proven choroidal lymphoma treated with ultra-low-dose radiotherapy.

Results: The three patients (two male, one female) of mean age 70 years (range, 64-74 years) demonstrated presenting visual acuity in the affected eye between 20/40 and 20/50. Read More

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http://dx.doi.org/10.1177/1120672119888985DOI Listing
November 2019