2,200 results match your criteria Ocular Lymphoma


Ocular recurrence of primary central nervous system diffuse large B-cell lymphoma: A case report.

Asian J Surg 2022 Jun 21. Epub 2022 Jun 21.

Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, PR China. Electronic address:

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pH Sensitive Pluronic Acid/Agarose-Hydrogels as Controlled Drug Delivery Carriers: Design, Characterization and Toxicity Evaluation.

Pharmaceutics 2022 Jun 8;14(6). Epub 2022 Jun 8.

Faculty of Pharmacy, Capital University of Science and Technology (CUST), Islamabad 44000, Pakistan.

The objective of this study was to fabricate and evaluate a pH sensitive cross-linked polymeric network through the free radical polymerization technique for the model drug, cyclophosphamide, used in the treatment of non-Hodgkin's lymphoma. The Hydrogels were prepared using a polymeric blend of agarose, Pluronic acid, glutaraldehyde, and methacrylic acid. The prepared hydrogels were characterized for drug loading (%), swelling pattern, release behavior, the ingredient's compatibility, structural evaluation, thermal integrity, and toxicity evaluation in rabbits. Read More

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Clinicopathologic Characteristics Associated with Prognosis in Ocular Extranodal Marginal Zone B Cell Lymphoma.

Medicina (Kaunas) 2022 Jun 17;58(6). Epub 2022 Jun 17.

Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 05505, Korea.

: Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) type is the most common subtype of the ocular adnexal lymphoma. Despite its excellent prognosis, some patients experience partial remission or progressive disease. We aimed to evaluate clinicopathologic differences in the treatment responder group by comparing complete remission (CR) and non-complete remission (non-CR). Read More

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Bilateral enlargement of all extraocular muscles: a presenting ophthalmic sign of hematologic malignancy.

Orbit 2022 Jun 22:1-4. Epub 2022 Jun 22.

Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

Hematologic malignancies such as leukemia and lymphoma can frequently present in the orbit; however, involvement of the extraocular muscles is rare. The authors report two cases of systemic hematologic malignancy presenting with bilateral extraocular muscle enlargement and associated compressive optic neuropathy (CON). Both patients experienced clinical and radiographic improvement of ocular and systemic manifestations of disease with prompt initiation of targeted chemotherapy. Read More

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Prevalence of Epstein-Barr Virus in Patients with Intraocular Inflammation.

Ocul Immunol Inflamm 2022 Jun 16:1-3. Epub 2022 Jun 16.

F.I. Proctor Foundation, San Francisco, California, USA.

The relationship between Epstein-Barr virus (EBV) infection and uveitis is unclear. We conducted an observational cross-sectional study to determine the prevalence of EBV in uveitis and to describe the clinical features of EBV-positive uveitis cases. This study was carried out at the F. Read More

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Clinical characteristics and outcomes of IgG4-positive marginal zone lymphoma: Systematic scoping review.

Pathol Int 2022 Jun 9. Epub 2022 Jun 9.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Immunoglobulin G4 (IgG4)-positive marginal zone lymphoma (MZL) is rare and undefined. It is unclear whether IgG4-positive MZLs have as favorable an outcome as MZLs in general. Also, correlation with IgG4-related disease (IgG4-RD) and IgG4-positive MZLs is unknown. Read More

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Malignancies in Immunoglobulin G4-related ophthalmic disease.

Eur J Ophthalmol 2022 Jun 8:11206721221102274. Epub 2022 Jun 8.

Department of Ophthalmology and Visual Sciences, 13621Prince of Wales Hospital, Hong Kong.

Purpose: Clinical phenotypes in Immunoglobulin G4-related disease (IgG4-RD) according to the patterns of affecting organs have different risks of malignancies. We attempt to determine the association of malignancies with IgG4-related ophthalmic disease (IgG4-ROD).

Design: Retrospective cohort study. Read More

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A deep learning model combining multimodal radiomics, clinical and imaging features for differentiating ocular adnexal lymphoma from idiopathic orbital inflammation.

Eur Radiol 2022 Jun 8. Epub 2022 Jun 8.

Xi'an Key Lab of Radiomics and Intelligent Perception, School of Information Science and Technology, Northwest University, Xi'an, 710069, Shaanxi, China.

Objectives: To evaluate the value of deep learning (DL) combining multimodal radiomics and clinical and imaging features for differentiating ocular adnexal lymphoma (OAL) from idiopathic orbital inflammation (IOI).

Methods: Eighty-nine patients with histopathologically confirmed OAL (n = 39) and IOI (n = 50) were divided into training and validation groups. Convolutional neural networks and multimodal fusion layers were used to extract multimodal radiomics features from the T1-weighted image (T1WI), T2-weighted image, and contrast-enhanced T1WI. Read More

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Investigation of epidemiological characteristics and development of a nomogram to predict survival in primary ocular adnexal lymphoma.

Clin Exp Ophthalmol 2022 Jun 3. Epub 2022 Jun 3.

Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: Studies on the epidemiology and prognosis of primary ocular adnexal lymphoma (POAL) are scarce for its low occurrence. The goal of our research was to assess the epidemiologic characteristics, prognostic variables, and survival of POAL patients.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to collect data on patients identified with POAL from 1975 to 2011 and the incidence rate of POAL from 1975 to 2017. Read More

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Cutaneous Involvement in Diseases with Plasma Cell Differentiation: Diagnostic Approach.

Curr Oncol 2022 04 24;29(5):3026-3043. Epub 2022 Apr 24.

Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy.

Neoplasms with plasma cell differentiation may occasionally involve the skin. Cutaneous lesions may represent the first sign of an underlying systemic plasma cell malignancy, such as multiple myeloma, or the skin itself may be the primary site of occurrence of a hematological tumor with plasma cell differentiation. Starting from examples encountered in our daily practice, we discussed the diagnostic approach pathologists and clinicians should use when faced with cutaneous lesions with plasma cell differentiation. Read More

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Cytology-Proven Primary Vitreoretinal Lymphoma in a Patient With Paraneoplastic Cloudy Vitelliform Submaculopathy.

JAMA Ophthalmol 2022 May 26. Epub 2022 May 26.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Vitamin D Deficiency in Primary Sjögren's Syndrome: Association with Clinical Manifestations and Immune Activation Markers.

Mediterr J Rheumatol 2022 Mar 31;33(1):106-108. Epub 2022 Mar 31.

Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Vitamin D is an agent involved in bone and mineral homeostasis. It has been recognized as a potent immunomodulator. It has immune-enhancing properties, and it induces immune tolerance. Read More

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Ocular adnexal lymphoma: A single-institution retrospective study.

Saudi J Ophthalmol 2021 Jul-Sep;35(3):230-238. Epub 2022 Apr 18.

Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To characterize demographic, clinical, and histopathologic features of ocular adnexal lymphoma (OAL) at a single institution.

Methods: Retrospective review of all patients with pathologic diagnosis of OAL between 2015 and 2020.

Results: There were 133 patients with OAL, with a median age of 65 years (range 23-97) and a slight female predominance (male: female = 1:1. Read More

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Long-Term Clinical Outcomes in Treatment-Naïve Patients With Orbital Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma: A Single-Center Study.

Front Oncol 2022 6;12:769530. Epub 2022 May 6.

Department of Hematology, Catholic University Lymphoma Group, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of South Korea, Seoul, South Korea.

Ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma (OAML) is the most common type of ocular lymphoma with a higher prevalence in Asia than in Western countries. OAML represents 1%-2% of all non-Hodgkin's lymphoma, 5%-15% of extranodal lymphomas, and approximately 55% of orbital malignancies. "Watch and wait" after biopsy or surgical resection, radiation therapy, and systemic treatment, including antibiotics administration and chemotherapy with various combinations of regimens can be considered for OAML treatment. Read More

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The Role of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Differential Diagnosis of Posterior Uveitis.

Ocul Immunol Inflamm 2022 May 20:1-8. Epub 2022 May 20.

Department of Biomedical and Clinical Science "Luigi Sacco," Eye Clinic, University of Milan, Milan, Italy.

Purpose: Modalities such as optical coherence tomography (OCT) and OCT angiography (OCTA) have improved the diagnostic utility of fundus imaging in management of uveitis. The purpose of this study is to review role of OCT and OCTA in differential diagnosis of certain posterior uveitic entities.

Methods: Narrative review. Read More

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Long-term outcomes of cataract surgery with toric intraocular lens implantation by the type of preoperative astigmatism.

Sci Rep 2022 May 19;12(1):8457. Epub 2022 May 19.

Sugita Eye Clinic, Tokyo, Japan.

Surgical outcomes of toric intraocular lens (IOL) implantation for 8 years after surgery were analyzed. Data were retrospectively collected in 176 eyes of 176 patients before and 1 month, 1, 3, 5, and 8 years after phacoemulsification and implantation of a toric IOL. Preoperative corneal and postoperative manifest astigmatism was analyzed by converting to power vector notations; horizontal/vertical (J) and oblique (J) astigmatism components. Read More

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The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways.

Cancer Res Commun 2021 Oct 13;1(1):1-16. Epub 2021 Oct 13.

Division of Hematology, Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL.

A comprehensive constellation of somatic non-silent mutations and copy number (CN) variations in ocular adnexa marginal zone lymphoma (OAMZL) is unknown. By utilizing whole-exome sequencing in 69 tumors we define the genetic landscape of OAMZL. Mutations and CN changes in CABIN1 (30%), RHOA (26%), TBL1XR1 (22%), and CREBBP (17%) and inactivation of TNFAIP3 (26%) were among the most common aberrations. Read More

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October 2021

Specific location of ocular adnexal lymphoma and mortality: an international multicentre retrospective study.

Br J Ophthalmol 2022 May 5. Epub 2022 May 5.

Eye Pathology Section, Department of Pathology, Rigshospitalet, Copenhagen, Denmark

Aims: To examine whether the specific location of ocular adnexal lymphoma (OAL) and the American Joint Committee on Cancer (AJCC) TNM tumour stage are prognostic factors for mortality in the main OAL subtypes.

Methods: Clinical and survival data were retrospectively collected from seven international eye cancer centres. All patients from 1980 to 2017 with histologically verified primary or secondary OAL were included. Read More

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Non-pegylated and Pegylated Interferon Alpha-2a in Cutaneous T-cell Lymphoma and the Risk of Severe Ocular Side-effects.

Acta Derm Venereol 2022 05 24;102:adv00722. Epub 2022 May 24.

Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, DE-68167 Mannheim, Germany.

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A Case of Tofacitinib-Induced Lymphomatoid Papulosis With Ocular Involvement.

Am J Dermatopathol 2022 Jul 4;44(7):523-525. Epub 2022 May 4.

Department of Dermatology, Oregon Health and Science University, Portland, OR.

Abstract: Janus kinase (JAK) inhibitors are being prescribed with increasing regularity in dermatology. We report on a patient who initiated treatment with tofacitinib for refractory erythema elevatum diutinum and subsequently developed a novel cutaneous outbreak characterized by firm violaceous papules on the trunk and extremities along with conjunctival injection and periorbital inflammation. Biopsy of affected tissue from both the cutaneous and ophthalmologic sources demonstrated increased numbers of CD30+ large atypical cells amid a mixed inflammatory cell infiltrate, consistent with lymphomatoid papulosis. Read More

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Primary Low Grade Follicular Lymphoma of the Conjunctivae Mimicking Nodular Anterior Scleritis: A Case Report.

Clin Med Res 2022 Apr 27. Epub 2022 Apr 27.

Department of Ophthalmology, Hospital Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, Selangor, Malaysia.

Conjunctival lymphomas are rare entities and may present with non-specific ocular signs that resemble inflammation. It may mimic common ocular pathologies, leading to a delay in its diagnosis and treatment. The treatment options of conjunctival lymphomas should be tailored to individuals due to their indolent nature compared to other adnexal lymphomas. Read More

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Management of primary choroidal lymphoma presenting as extensive serous retinal detachment and salmon patch of bulbar conjunctiva: a case report.

J Med Case Rep 2022 Apr 24;16(1):162. Epub 2022 Apr 24.

Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: We describe the outcome of ultra-low-dose radiotherapy plus intravitreal methotrexate and rituximab injections for a patient with primary choroidal lymphoma who presented with nodular conjunctival salmon patches and extensive serous retinal detachment.

Case Presentation: A 34-year-old Iranian man presented with a nodular patch of bulbar conjunctiva in the right eye, and 1+ vitritis. A nearly complete shallow serous retinal detachment, retinal folds, and multifocal yellow choroidal infiltrates were seen during a fundus examination of the right eye. Read More

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Updates on HTLV-1 Uveitis.

Viruses 2022 04 12;14(4). Epub 2022 Apr 12.

Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

HTLV-1 uveitis (HU) is the third clinical entity to be designated as an HTLV-1-associated disease. Although HU is considered to be the second-most frequent HTLV-1-associated disease in Japan, information on HU is limited compared to that on adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). Recent studies have addressed several long-standing uncertainties about HU. Read More

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Changing Trends in Uveitis in the United Kingdom: 5000 Consecutive Referrals to a Tertiary Referral Centre.

Ocul Immunol Inflamm 2022 Apr 20:1-6. Epub 2022 Apr 20.

Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Purpose: To demonstrate changes in the demography and diagnosis of uveitis in a specialist clinic in the United Kingdom.

Methods: Retrieval of data including all new referrals to Manchester Uveitis Clinic from 1991 to 2020. The incidence and proportions of diagnoses between 4 quartiles was compared. Read More

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Humoral Responses Against SARS-CoV-2 and Variants of Concern After mRNA Vaccines in Patients With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia.

J Clin Oncol 2022 Apr 18:JCO2200088. Epub 2022 Apr 18.

Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.

Purpose: Patients with non-Hodgkin lymphoma including chronic lymphocytic leukemia (NHL/CLL) are at higher risk of severe SARS-CoV-2 infection. We investigated vaccine-induced antibody responses in patients with NHL/CLL against the original SARS-CoV-2 strain and variants of concern including B.1. Read More

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Lupus-Induced Myopic Shift.

Cureus 2022 Mar 8;14(3):e22961. Epub 2022 Mar 8.

Department of Ophthalmology, University of South Florida (USF) Health Morsani College of Medicine, Tampa, USA.

While ophthalmic manifestations of lupus are common, a myopic shift is a rare manifestation of systemic lupus erythematosus (SLE). An acute myopic shift is defined as a progressive worsening of nearsighted vision within a short time frame. Here, we describe the unique presentation of a young woman with a lupus-induced acute myopic shift. Read More

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Extranodal Marginal Zone Lymphoma: Pathogenesis, Diagnosis and Treatment.

Cancers (Basel) 2022 Mar 29;14(7). Epub 2022 Mar 29.

Hematology, Departement of Traslational and Precision Medicine, Sapienza University of Rome, 00161 Rome, Italy.

Extranodal Marginal Zone Lymphoma (EMZL lymphoma) is an indolent B-cell lymphoma with a median age at diagnosis of about 60 years. It accounts for 7-8% of all B-cell lymphomas. It can occur in various extranodal sites, including stomach, lung, ocular adnexa, and skin; furthermore, the disseminated disease can be found in 25-50% of cases. Read More

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[Treatment and prognosis of primary ocular adnexal extranodal marginal zone mucosa-associated lymphoid tissue lymphoma: a report from a single center].

Zhonghua Xue Ye Xue Za Zhi 2022 Mar;43(3):209-214

Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

This study aimed to see how different initial treatment regimens affected the long-term prognosis of patients with extranodal marginal zone mucosa-associated lymphoid tissue lymphoma confining to the ocular adnexal (OAML) . Between April 2008 and April 2019, 109 patients with initial mucosa-associated lymphoid tissue confining to ocular adnexal were evaluated and followed-up, and the prognosis of various initial treatment regimens were examined. A total of 36 patients underwent complete surgical resection of the lesions, and 73 patients had residual lesions after surgery, of which 37 patients chose watchful waiting, and 36 patients chose treatment. Read More

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Orbital Mass as the Only Presenting Sign with Overlapping Features of Lupus Erythematosus Panniculitis and Subcutaneous Panniculitis-Like T-Cell Lymphoma.

Ocul Immunol Inflamm 2022 Apr 11:1-4. Epub 2022 Apr 11.

Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Purpose: Even though subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and lupus erythematosus panniculitis (LEP) are two separate entities, recently they were claimed to represent two ends of a spectrum of T-cell-mediated orbital lymphoproliferative diseases.

Methods: A 78-year-old woman presented with a 1-month history of right-sided periorbital swelling and redness. There was a palpable mass in the medial right lower eyelid with restriction of upward and lateral gaze. Read More

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Clinical Features of Primary Vitreoretinal Lymphoma: A Single-center Study.

Cancer Diagn Progn 2021 May-Jun;1(2):69-75. Epub 2021 May 3.

Department of Ophthalmology, Faculty of Medicine andGraduate School of Medicine, Hokkaido University, Sapporo, Japan.

Background/aim: This study aimed to demonstrate the clinical outcomes of primary vitreoretinal lymphoma (PVRL).

Patients And Methods: Seventeen patients with PVRL who had been treated at Hokkaido University Hospital were enrolled in this study. They were diagnosed based on their cytology, interleukin-10/-6 ratio, and immunoglobulin heavy chain (IgH) gene rearrangement. Read More

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