2,037 results match your criteria Ocular Lymphoma


The role of imaging technologies for ocular surface tumors.

Curr Opin Ophthalmol 2021 May 11. Epub 2021 May 11.

Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts Bascom Palmer Eye Institute, Department of Ophthalmology University of Miami, Miami, Florida, USA.

Purpose Of Review: This review will discuss the utility of high-resolution anterior segment optical coherence tomography (HR-OCT), in-vivo confocal microscopy (IVCM) and ultrasound biomicroscopy (UBM) in characterizing and diagnosing various ocular surface tumors, namely ocular surface squamous neoplasia (OSSN), conjunctival lymphoma and conjunctival melanoma. The strengths and limitations of each imaging modality will be discussed along with the characteristics findings of each lesion on each imaging platform.

Recent Findings: HR-OCT can consistently be utilized in the clinic setting to distinguish between epithelial ocular surface tumors such as OSSN as compared with subepithelial tumors such as conjunctival lymphoma and conjunctival melanoma given their distinctive findings. Read More

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Hodgkin Lymphoma Associated Retinopathy: Report of a Case.

Ocul Immunol Inflamm 2021 May 13:1-3. Epub 2021 May 13.

Université de Paris, Department of Ophthalmology, Hôpital Cochin, Paris, France.

: To report a case of Hodgkin lymphoma (HL) associated retinopathy.: Single-case, retrospective review of ophthalmological and systemic manifestations.: A bilateral panuveitis in a 17-year-old Caucasian woman led to the diagnosis of HL. Read More

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Primary Vitreoretinal Lymphoma Therapy Monitoring: Significant Vitreous Haze Reduction After Intravitreal Rituximab.

Neurosignals 2021 05;29(S1):1-7

Department of Ophthalmology, Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Background/aims: Intravitreal rituximab is an off-label treatment option for primary vitreoretinal lymphoma (PVRL). The objective of this study was to monitor the therapeutic response and safety profile of intravitreal rituximab in a cohort of PVRL patients.

Methods: In this retrospective, uncontrolled, open label, multicentre study, 20 eyes from 15 consecutive patients diagnosed with PRVL received at least one intravitreal injection of 1mg in 0. Read More

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Ocular Oncology-Primary and Metastatic Malignancies.

Med Clin North Am 2021 May 2;105(3):531-550. Epub 2021 Apr 2.

Medicine, 231 Albert Sabin Way, Suite 5412, Cincinnati, OH 45267-0567, USA. Electronic address: https://twitter.com/mauradinicola.

Several neoplastic processes can involve the eye, either primarily or secondary to a systemic malignancy. The most common primary tumors of the eye include conjunctival and uveal melanoma, retinoblastoma, conjunctival and intraocular lymphoma, and ocular surface squamous neoplasia. Metastatic spread from systemic malignancies, especially of the breast and lung, also can involve the eye. Read More

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Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells.

Int J Mol Sci 2021 Apr 15;22(8). Epub 2021 Apr 15.

Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers, edits ribonucleotides to induce somatic hypermutation and class switching of immunoglobulin. While AID expression is strictly controlled under physiological conditions, chronic inflammation has been noted to induce its upregulation to propel oncogenesis. Read More

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[Clinical and pathological analysis of ocular adnexal diffuse large B-cell lymphoma].

Zhonghua Yan Ke Za Zhi 2021 May;57(5):366-371

Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin 300020, China.

To summarize the clinical and pathological characteristics of diffuse large B-cell lymphoma of ocular adnexal (OA-DLBCL). A retrospective case series study. Twenty-three cases of OA-DLBCL were collected in Tianjin Eye Hospital from January 2005 to December 2018. Read More

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Efficacy and safety of intravitreal methotrexate for vitreo-retinal lymphoma - 20 years of experience.

Br J Haematol 2021 Apr 26. Epub 2021 Apr 26.

Ocular Oncology Service, Division of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel.

Vitreo-retinal lymphoma (VRL) is the most common intraocular lymphoma and is highly associated with central nervous system (CNS) lymphoma (CNSL), both posing a therapeutic challenge. We investigated patients' characteristics, efficacy and safety of intravitreal methotrexate (MTX) injections and their outcomes over 20 years. The records of 129 patients diagnosed between 1997 and 2018 were retrospectively reviewed. Read More

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Ocular involvement in extranodal natural-killer T-cell lymphoma.

Lancet Haematol 2021 05;8(5):e382

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.

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A Case Report of a Primary Conjunctival Diffuse Large B-Cell Lymphoma: Keeping an Eye out Following a Nasopharyngeal Carcinoma.

Cureus 2021 Mar 15;13(3):e13904. Epub 2021 Mar 15.

Internal Medicine, Immunohematology and Cellular Therapy Laboratory, Medical School of Oujda, Mohammed First University, Oujda, MAR.

Primary diffuse large B cell lymphoma of the conjunctiva is a rare disease. In this article, we report the case of a 40-year-old man who had previously been treated with chemotherapy and radiotherapy for undifferentiated carcinoma of nasopharyngeal type (UCNT) and who subsequently developed conjunctival lymphoma. We underline through this observation the importance of thinking about a secondary cancer post-radio-chemotherapy even when the clinical presentation is atypical. Read More

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Clinical features and treatment outcomes of intraocular lymphoma: a single-center experience in China.

Int J Ophthalmol 2021 18;14(4):574-581. Epub 2021 Apr 18.

Department of Ophthalmology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China.

Aim: To investigate the clinical manifestations, diagnostic approaches, treatments, and outcomes of intraocular lymphoma.

Methods: In this retrospective study, 16 patients (28 eyes) with intraocular lymphoma were recruited in the Department of Ophthalmology, Peking Union Medical College Hospital, from 2004 to 2019. All patients underwent comprehensive ophthalmic examinations. Read More

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Diffuse large B-cell lymphoma presenting with ocular involvement in an 8-year-old boy.

Can J Ophthalmol 2021 Apr 15. Epub 2021 Apr 15.

Cumming School of Medicine, University of Calgary, Calgary, Alb.

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Intravenous high-dose methotrexate based systemic therapy in the treatment of isolated primary vitreoretinal lymphoma: An LOC network study.

Am J Hematol 2021 Apr 17. Epub 2021 Apr 17.

Ophthalmology, Centre Hospitalier Universitaire de Brest, Brest, France.

The treatment of primary vitreoretinal lymphoma (PVRL) remains controversial regarding the use of local, systemic, or combined treatments. The aim of this study was to analyze the efficacy and toxicity of intravenous high-dose methotrexate (IV HD-MTX) based systemic therapy in a uniformly treated population of PVRL patients. From a nationwide French database, we retrospectively selected 59 patients (median age: 70 years, median Karnofsky Performance Status: 90%) with isolated PVRL at diagnosis who received first-line treatment with HD-MTX between 2011 and 2018. Read More

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Epidemiology of Marginal Zone Lymphoma.

Ann Lymphoma 2021 Mar 30;5. Epub 2021 Mar 30.

Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

In 2016 there were an estimated 7,460 newly diagnosed patients with marginal zone lymphoma (MZL) in the US, which comprised 7% of all mature non-Hodgkin lymphomas (NHL). Based on data from the US SEER-18 program from 2001-2017, the age-standardized incidence rate for MZL was 19.6 per 1,000,000 person-years; 9% of MZL cases were splenic MZL (SMZL), 30% nodal MZL (NMZL), and 61% extranodal MZL (EMZL) of mucusa-associated lymphoid tissue (MALT). Read More

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Second primary malignancies after ocular adnexal lymphoma diagnosis.

BMC Ophthalmol 2021 Apr 7;21(1):162. Epub 2021 Apr 7.

Baylor College of Medicine, Department of Ophthalmology-Cullen Eye Institute, 1977 Butler Boulevard, Houston, TX, 77030, USA.

Background: Although studies have investigated the risk of second primary malignancies (SPMs) associated with lymphoma of various sites, limited studies have investigated this risk in patients with lymphoma originating within the ocular adnexa. We conducted a retrospective study to assess incidence of secondary malignancies in patients with a prior diagnosis of ocular adnexal lymphoma (OAL) and to determine latency periods and age-groups at increased risk for SPM occurrence.

Methods: Retrospective analysis was performed on data obtained from Surveillance, Epidemiology, and End Results (SEER) 9 database. Read More

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Causes and Clinical Manifestations of Masquerade Syndromes in Intraocular Inflammatory Diseases.

Retina 2021 Mar 30. Epub 2021 Mar 30.

Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.

Objective: To identify the clinical characteristics and prevalence of neoplastic and non-neoplastic inflammatory masquerade syndromes (IMS) in a tertiary center and determine the useful diagnostic tests.

Methods: A retrospective cohort study of consecutive 1906 patients diagnosed with intraocukar inflammatory disease (IID).

Results: Out of all patients initially diagnosed with IID, 116 (6%) patients were due to non-inflammatory causes (neoplastic IMS in 36/116; 31% and non-neoplastic IMS in 52/116; 45%). Read More

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SARS-CoV-2 Infection and Antibody Response in a Symptomatic Cat from Italy with Intestinal B-Cell Lymphoma.

Viruses 2021 03 23;13(3). Epub 2021 Mar 23.

Clinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.

Since the coronavirus disease (COVID-19) pandemic was first identified in early 2020, rare cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in pet cats have been reported worldwide. Some reports of cats with SARS-CoV-2 showed self-limiting respiratory or gastrointestinal disease after suspected human-to-feline transmission via close contact with humans with SARS-CoV-2. In the present study, we investigated a cat with SARS-CoV-2 that was presented to a private animal clinic in Northern Italy in May 2020 in a weak clinical condition due to an underlying intestinal B-cell lymphoma. Read More

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Computerized Tomography-Guided Core-Needle Biopsy of Orbital Space-Occupying Lesions: A Case Series.

Ocul Oncol Pathol 2021 Mar 30;7(1):54-61. Epub 2020 Nov 30.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Purpose: To describe our experience in performing biopsy of post-septal orbital masses with core needle under computerized tomography guidance (CT-CNB).

Methods: The medical records of all patients who underwent this procedure were reviewed. The procedure was performed under local anesthesia on a day case basis under a peribulbar block. Read More

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Double-hit and triple-hit high-grade B-cell lymphoma of the ocular adnexa.

Orbit 2021 Mar 29:1-5. Epub 2021 Mar 29.

Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

High-grade B-cell lymphoma (HGBL) with and and/or rearrangements, also known as a double-hit and triple-hit lymphoma, is an aggressive non-Hodgkin lymphoma affecting older adults. After formal recognition of this entity in the 2017 revision of the World Health Organization Classification of lymphoid neoplasms, only two well-documented cases of triple-hit lymphoma of the orbit appear in the literature. Herein, we describe a 70-year-old man with progressive diplopia, ophthalmoplegia, and rapidly enlarging temporal mass. Read More

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Radiotherapy as Salvage Treatment in Intraocular Lymphoma: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):184-189. Epub 2021 Mar 1.

Radiotherapy Department, Instituto Português de Oncologia Francisco Gentil E.P.E, Lisbon, Portugal.

A 67-year-old previously healthy woman presented with progressive visual impairment including bitemporal hemianopsia. A brain magnetic resonance imaging revealed a contrast-enhancing mass in the optic chiasm, spreading along the left optic tract. The patient underwent a transcranial biopsy of the left optical tract that yielded a diagnosis of diffuse large B-cell lymphoma. Read More

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Clinical Features and Prognoses of IgG4-Positive and IgG4-Negative Lacrimal Lymphomas.

Front Oncol 2021 8;11:622847. Epub 2021 Mar 8.

Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

The clinical characteristics and prognoses of immunoglobulin G4-positive (IgG4+) and IgG4-negative (IgG4-) lacrimal lymphomas were comparatively analyzed to screen for clinical indicators with differential diagnostic significance. This was a retrospective and single-center clinical study. From June 2011 to June 2018, clinical data of 39 patients with lacrimal lymphoma, diagnosed by histopathology were collected from the Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University. Read More

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Primary central nervous system lymphoma - ocular variant: an interdisciplinary review on management.

Surv Ophthalmol 2021 Mar 21. Epub 2021 Mar 21.

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Primary central nervous system lymphoma-ophthalmic variant (PCNSL-O) is an ocular subset of PCNSL predominantly involving subretinal pigment epithelium space, retina, and vitreous. The ophthalmic manifestations can precede, occur simultaneously, or follow other compartments of the CNS. Clinical trials have resulted in a significantly improved outcome in PCNSL patients over the past 2 decades, with a higher proportion of patients receiving frontline high dose methotrexate-based polychemotherapy regimens with curative intent; however, the current management of PCNSL-O remains controversial owing to lack of prospective data. Read More

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A rare case of orbital myositis.

J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S706-S708

Department of Radiology, Shifa International Hospital, Islamabad, Pakistan.

The orbital myositis is a rare inflammatory disorder of extraocular muscles and is considered a subtype of nonspecific orbital inflammatory syndrome. It is usually a unilateral disease process with a limited course. We report a case of a 34-year-old man who was referred to the Radiology Department at Shifa International Hospital, Islamabad with 6 months history of severe pain, swelling, and redness in the left eye associated with blurring of vision and headache. Read More

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Morphologic Cross-Sectional Imaging Features of IgG4-Related Orbitopathy in Comparison to Ocular Adnexal Lymphoma.

Clin Ophthalmol 2021 12;15:1119-1127. Epub 2021 Mar 12.

Department of Radiology, Ludwig-Maximilians-University, Munich, Germany.

Aim: To detect radiological features that, in addition to clinical findings, may aid in correct differentiation between IgG4-related ophthalmic disease (IgG4-ROD) and ocular adnexal lymphoma (OAL).

Methods: In this retrospective, single-center, comparative analysis, we compared cross-sectional imaging findings of 13 consecutive patients with histologically proven IgG4-ROD and a control group of 29 consecutive OAL-patients diagnosed between 10/2014 and 09/2019. Statistical significance was accepted at a <0. Read More

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Utility of enface optical coherence tomography in intraocular lymphoma.

Retin Cases Brief Rep 2021 Mar 4. Epub 2021 Mar 4.

Dept. of Retina and Vitreous Narayana Nethralaya, #121/C, 1 R Block, Chord road, Rajaji Nagar, Bengaluru - 560010 Dept. of Uvea and ocular inflammation, Narayana Nethralaya, #121/C, 1 R Block, Chord road, Rajaji Nagar, Bengaluru - 560010.

Purpose: To report the enface optical coherence tomography (OCT) features of intraocular lymphoma.

Methods: Retrospective, observational case reportCase description A 59-year-old man, a known case of primary testicular carcinoma complained of right eye blurred vision since 1-week. He had undergone systemic intravenous chemotherapy (R-CHOP regime), orchiectomy and external beam radiotherapy for the primary malignancy previously. Read More

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Intravitreal rituximab monotherapy for management of eyes with vitreoretinal lymphoma: initial experience from India.

Int Ophthalmol 2021 Mar 17. Epub 2021 Mar 17.

L&T Ocular Pathology Department, Medical Research Foundation, 18 College Road, Chennai, Tamilnadu, 600006, India.

Purpose: To evaluate treatment outcomes and complications of intravitreal rituximab (IVR) monotherapy for eyes with vitreoretinal lymphoma (VRL).

Methods: Patients diagnosed with 'isolated primary VRL' or 'VRL with remission of systemic disease' and treated with IVR (1 mg/0.1 ml) between June 2014 and June 2019 were included in this retrospective, interventional case series. Read More

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Ocular Adnexal MALT Lymphoma in Association With Rosai-Dorfman Disease in a Child.

Ophthalmic Plast Reconstr Surg 2021 Mar 8. Epub 2021 Mar 8.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida Oculofacial Plastic and Reconstructive Surgery, Bascom Palmer Eye Institute, Miami, Florida, U.S.A.

A 12-year-old boy presented with persistent proptosis and periorbital swelling after a school altercation. MRI revealed a mass in the right superonasal orbit extending along the orbital roof to the frontal bone and right frontal sinus, and intracranially to the dura of the right frontal lobe. Immunohistochemistry revealed CD20- and CD43-positive B cells consistent with a low-grade B-cell lymphoma. Read More

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Conjunctival lymphoma presenting as ptosis in an asymptomatic older adult.

Clin Exp Optom 2021 Feb 26:1-2. Epub 2021 Feb 26.

University of Alabama at Birmingham School of Optometry, Birmingham, AL, USA.

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February 2021

Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma.

J Med Radiat Sci 2021 Mar 6. Epub 2021 Mar 6.

Radiation Oncology Network, Western Sydney Local Health District, Sydney, NSW, Australia.

Introduction: Most primary ocular adnexal lymphomas are those involving mucosa-associated lymphoid tissue (MALT). Radiotherapy (RT) dose regimens in the literature vary from the historically used high doses (up to 56 Gy) to lower dose RT. We aimed to examine our institution's experience with the use of orbital RT for treating early-stage primary ocular adnexal MALT lymphoma (POAML). Read More

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Ocular Toxoplasmosis Mimicking Lymphoma: Exploring the Correlation and Distinction.

Cureus 2021 Jan 30;13(1):e13014. Epub 2021 Jan 30.

Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA.

We present a case of a 74-year-old woman with chronic lymphocytic leukemia (CLL) who presented with unilateral blurry vision that had progressively worsened over a few weeks. Ophthalmic examination revealed unilateral anterior chamber, vitreous body inflammation along with retinal infiltration which was initially diagnosed with posterior uveitis. Analysis of vitreous fluid aspiration was negative for bacteria, fungal and viral etiologies. Read More

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January 2021