Search Our Scientific Publications & Authors

Int Ophthalmol 2022 May 20. Epub 2022 May 20.

Sadik Eratik Eye Institute, Haydarpasa Numune Education and Research Hospital, University of Health Sciences, Tibbiye Cad. No: 23, 34668, Uskudar, Istanbul, Turkey.

Purpose: To analyze the risk factors and ocular hypotony characteristics of choroidal detachment (CD) after penetrating glaucoma surgery and to compare between eyes with and without CD.

Methods: This retrospective study enrolled 173 eyes of 168 patients. Patients who underwent trabeculectomy or Ahmed glaucoma valve implantation due to medically uncontrolled glaucoma and who had intraocular pressure (IOP) < 9 mmHg at any time during the first postoperative week were included. Read More

Ophthalmol Retina 2022 May 16. Epub 2022 May 16.

California Retina Consultants, Santa Barbara, California.

Purpose: To provide strategies for the management of key ocular adverse events (AEs) that may be encountered with the Port Delivery System with ranibizumab (PDS) in practice, and to provide recommendations that may mitigate such AEs based on clinical trial experience and considerations from experts in the field.

Design: Safety evaluation based on the phase 2 Ladder (NCT02510794) and phase 3 Archway (NCT03677934) trials of the PDS.

Methods: The PDS is a permanent, indwelling, and refillable ocular drug delivery system that requires standardized procedural steps, for its insertion and refill-exchange procedures, which have evolved during the PDS clinical program. Read More

J Glaucoma 2022 May 17. Epub 2022 May 17.

Grupo Oftalvist, Alicante , Spain.

Prcis: The PSM® is a safe and effective glaucoma micro-filtering implant that significantly reduces the intraocular pressure, either alone or in combination with phacoemulsification, during the first year after surgery.

Purpose: To assess the safety and efficacy of the Preserflo Microshunt® (PSM®) for the treatment of open angle glaucoma with 0.2▒mg/ml mytomicin C (MMC), either alone or in combination with cataract surgery. Read More

Am J Ophthalmol Case Rep 2022 Jun 3;26:101571. Epub 2022 May 3.

Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, USA.

Purpose: Suprachoroidal intraocular foreign bodies (IOFBs) are an exceedingly rare manifestation of ocular trauma. Here we present a unique case of a metallic wire tracking from the cornea through the suprachoroidal space, and remarkably sparing the retina and lens. The patient attained an excellent visual outcome after management of resultant cyclodialysis cleft. Read More

Korean J Ophthalmol 2022 May 6. Epub 2022 May 6.

Department of Ophthalmology, Hanyang University Seoul Hospital, Seoul, Korea.

Transl Vis Sci Technol 2022 Apr;11(4):24

Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.

Purpose: To improve outcomes for subretinal implantation surgery in pigs.

Methods: Analysis of variables affecting the success of subretinal implantation surgery was performed on videos of 37 surgeries. Ex vivo experiments were conducted to measure intraocular pressure (IOP) and test various prototyped implanters for effectiveness at maintaining IOP. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Apr 18. Epub 2022 Apr 18.

Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Purpose: Myopic glaucoma patients display a considerable risk of complications following antiglaucomatous filtering surgery, e.g., trabeculectomy. Read More

Cell Death Dis 2022 Apr 9;13(4):323. Epub 2022 Apr 9.

Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

The purpose of this study was to design an animal model mimicking glaucoma with hemodynamic instability and to identify involvement of angiotensin II (AngII) and associated changes of the retina. Systemic hypotension was induced in Sprague-Dawley rats by oral hydrochlorothiazide administration. Rats were sacrificed at 4, 8, and 12-week time points. Read More

BMC Ophthalmol 2022 Apr 1;22(1):149. Epub 2022 Apr 1.

Department of Ophthalmology, Northwestern University Feinberg School of Medicine, 645 N. Michigan Ave, #440, Chicago, Illinois, 60611, USA.

Background: This study aims to describe outcomes of posteriorly-placed glaucoma drainage devices (GDD) with concurrent endoscopic vitrectomy in pediatric patients with glaucoma and corneal opacification.

Methods: This retrospective case series identified patients under 18 years of age who underwent posteriorly-placed GDD implantation with concurrent endoscopic vitrectomy between 2012 and 2021. Data collected included ocular diagnoses, prior intraocular surgeries, type and position of GDD, surgical complications, and additional surgeries. Read More

Eye (Lond) 2022 Mar 28. Epub 2022 Mar 28.

Department of Ophthalmology, Tan Tock Seng Hospital, National Healthcare Group Eye Institute, Singapore, Singapore.

Background: The XEN45 Gel Stent is a subconjunctival filtering device that has demonstrated promising efficacy. This meta-analysis quantitatively evaluates reported complications and interventions after XEN45 implantation in the treatment of open angle glaucoma (OAG).

Methods: Pilot, cohort, observational studies, and randomised controlled trials that included at least ten patients undergoing ab interno or externo XEN45 surgery, with or without phacoemulsification were deemed eligible for inclusion. Read More

J Anaesthesiol Clin Pharmacol 2021 Oct-Dec;37(4):580-585. Epub 2022 Jan 6.

Department of Anaesthesiology and Critical Care, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India.

Background And Aims: AA present prospective study was conducted to evaluate ocular changes occurring in patients undergoing spine surgery in the prone position.

Material And Methods: A total of 44 patients of either sex, belonging to American society of Anaesthesiology I and II (aged 18-60 years) scheduled for elective spine surgery in prone position were enrolled in the study. Baseline IOP and MAP measurement were taken prior to induction. Read More

Indian J Ophthalmol 2022 Apr;70(4):1248-1252

Department of Ophthalmology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.

Purpose: To comparatively evaluate in Indian eyes with coexisting cataract and primary open-angle glaucoma the outcome of mitomycin C (MMC) and Ologen implant as adjunctives in combined phacoemulsification with trabeculectomy.

Methods: Eyes with primary open-angle glaucoma that underwent trabeculectomy and phacoemulsification with IOL implantation with either MMC application or Ologen implant between June 2019 and February 2020 were followed up for 12 months. Thirty-four eyes of 34 participants were studied. Read More

Klin Monbl Augenheilkd 2022 Apr 23;239(4):435-442. Epub 2022 Mar 23.

Department of Ophthalmology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Purpose: To evaluate the 2-year surgical treatment outcome in glaucoma patients.

Methods: A retrospective, single-center, interventional study was performed on 160 eyes of 125 patients suffering glaucoma, including POAG (82 eyes), pseudoexfoliation (PEX) (59 eyes), pigment dispersion (8 eyes), and secondary glaucoma (2 eyes). Eyes with uncontrolled intraocular pressure (IOP) or signs of glaucoma progression despite medical treatment were included to undergo either trabeculectomy (TE), XEN implantation, combined TE with phacoemulsification (TE + IOL), or XEN implantation with phacoemulsification surgery (XEN + IOL). Read More

Ophthalmol Ther 2022 Jun 22;11(3):1273-1279. Epub 2022 Mar 22.

Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Rocky Mountain Lions Eye Institute, 1675 Aurora Court, Aurora, CO, 80045, USA.

Purpose: All published cases of iris retraction syndrome have been associated with low intraocular pressure. We report here a case clinically indistinguishable from iris retraction syndrome except for the absence of hypotony, which has not been previously described in the literature.

Observations: A 35-year-old woman with a history of atopic dermatitis developed a rapidly progressive anterior subcapsular cataract and acute uveitis. Read More

Am J Ophthalmol Case Rep 2022 Jun 15;26:101483. Epub 2022 Mar 15.

Department of Ophthalmology & Visual Sciences, QEII Health Sciences Centre, 2035-2 West Victoria Building, 1276 South Park Street, Halifax, NS, CA B3H 2Y9, Canada.

Purpose: We present multimodal imaging of an interesting case of a 78-year-old man who developed large ciliochoroidal detachments and macular subretinal and intraretinal fluid in the right eye following bilateral neodymium-doped yttrium aluminium garnet (Nd:YAG) laser peripheral iridotomies (LPIs).

Observations: The ciliochoroidal detachments developed in the absence of documented post-procedure hypotony or intraocular pressure fluctuation. Ultrasound biomicroscopy (UBM) confirmed serous ciliochoroidal detachment. Read More

Am J Ophthalmol Case Rep 2022 Jun 15;26:101478. Epub 2022 Mar 15.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine Hokkaido University, Sapporo, Japan.

Purpose: Cerebrospinal fluid hypovolemia syndrome (CHS) is a rare clinical entity that can be caused by spontaneous cerebrospinal fluid (CSF) leakage. The aim of this study is to report a rare case of CHS after a traffic accident in a patient who presented with diplopia and ptosis with fluctuation and was initially diagnosed with ocular myasthenia gravis.

Observeations: A 29-year-old man exhibited fluctuating left ptosis and diplopia after a traffic accident. Read More

BMJ Case Rep 2022 Mar 8;15(3). Epub 2022 Mar 8.

The Colchester Eye Centre of Excellence, East Suffolk and North Essex NHS Foundation Trust, Colchester, UK.

We present a previously undescribed case of a persistent hypotony maculopathy secondary to an iatrogenic cyclodialysis cleft created during XEN-45 gel stent insertion. We present this case as a further analysis of the case of cyclopexy by the corresponding surgeon. Following right XEN-45 implantation, our patient developed immediate and persistent postoperative hypotony for 4 weeks. Read More

J Glaucoma 2022 May 7;31(5):335-339. Epub 2022 Mar 7.

Mayo Clinic College of Medicine, Jacksonville, FL.

Prcis: Designed with novel features to facilitate implantation and improve safety, the Ahmed ClearPath (ACP) glaucoma drainage device (GDD) provided intraocular pressure (IOP) reduction comparable with other GDDs in eyes with refractory glaucoma in a multicenter retrospective study.

Purpose: To present clinical outcomes with a novel valveless GDD (ACP, New World Medical). The 250 and 350 mm2 models feature a contoured plate for optimal globe apposition, anteriorized suture points to facilitate suturing to the globe, and a prethreaded 4-0 polypropylene ripcord suture. Read More

Arch Soc Esp Oftalmol (Engl Ed) 2022 Mar 15;97(3):165-167. Epub 2021 May 15.

Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.

A cyclodialysis cleft is a rare disease that is produced as a result of a separation of the longitudinal fibers of the ciliary body muscle from the scleral spur. A stepwise approach is the best course of action to treat cyclodialysis, starting with medical therapy and continuing with more invasive surgical options. We report a case of ocular hypotony due a traumatic cyclodialysis successfully resolved with transscleral cryotherapy. Read More

Indian J Ophthalmol 2022 Mar;70(3):1073

Glaucoma Services, Aravind Eye Hospital and Post-Graduate Institute, Tirunelveli, Tamil Nadu, India.

Background: Hypotony secondary to overfiltration is a recognized complication following trabeculectomy. Persistent hypotony requires intervention .

Purpose: We describe a modified version of placing conjunctival compression sutures directly over the scleral flap. Read More

BMJ Case Rep 2022 Feb 25;15(2). Epub 2022 Feb 25.

Advanced Eye Centre, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India

Haemorrhagic choroidal detachment (HCD) is a dreaded intraoperative complication of ophthalmic surgery, despite being rare. Multiple systemic and ocular risk factors of HCD have been reported. Acute hypotony during surgery is considered one of the most important precipitating factors. Read More

J Ophthalmol 2022 8;2022:8566044. Epub 2022 Feb 8.

University of Zurich, Medical Faculty, Zurich, Switzerland.

Purpose: The aim of this study was to compare effectiveness and safety of MicroPulse transscleral laser therapy (MP-TLT) using the original MicroPulse P3® device and continuous-wave transscleral cyclophotocoagulation (CW-TSCPC) using the G-Probe® device in glaucoma.

Methods: Spherical equivalent, intraocular pressure (IOP), best-corrected visual acuity (BCVA), and number of topical or oral ophthalmic pressure-reducing medications were registered at every time point, up to the last follow-up at 12 months. A complete slit-lamp examination was conducted to record the following complications: corneal edema, persistent ocular hypotony (IOP ≤5 mmHg) on two consecutive follow-up visits, choroidal detachment, phthisis bulbi, sympathetic ophthalmia, cystoid macular edema, or other abnormal ocular findings. Read More

BMC Ophthalmol 2022 Feb 15;22(1):78. Epub 2022 Feb 15.

Department of Ophthalmology, Dankook University Hospital, College of Medicine, Dankook University, Cheonan, Republic of Korea.

Background: To assess the time, incidence, and outcome of posterior segment complications of Ahmed valve implantation (AVI).

Methods: 248 eyes that underwent AVI were reviewed retrospectively. Visual acuity, preoperative characteristics, and postoperative posterior segment complications were assessed. Read More

Invest Ophthalmol Vis Sci 2022 02;63(2):23

Université de la Polynésie française, Tahiti, French Polynesia.

Purpose: The purpose of this study was to investigate whether the lamina cribrosa (LC) curve changes in response to intraocular pressure (IOP) reduction following administration of topical ocular hypotensive eye drops in eyes with normal tension glaucoma (NTG).

Methods: Ninety-three eyes of 93 patients with treatment naïve NTG at initial examination and with ≥20% reduction from baseline IOP following administration of topical ocular hypotensive eye drops were included. Serial horizontal B-scan images of the optic nerve head (ONH) were obtained from each eye using enhanced depth imaging spectral domain optical coherence tomography (OCT) before and 1 year after IOP-lowering treatment. Read More

Ocul Oncol Pathol 2021 Dec 21;7(6):390-395. Epub 2021 Sep 21.

Department of Ophthalmology and Visual Sciences, Havener Eye Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Background: Idiopathic systemic capillary leak syndrome (ISCLS, also known as Clarkson's disease) is a rare medical condition characterized by episodes of capillary endothelial cell dysfunction with leakage of fluid into the interstitial space resulting in severe hypotension, hemoconcentration, hypoalbuminemia, and generalized edema. Each episode can result in multiorgan failure due to systemic hypoperfusion.

Case Presentation: We report a case of uveal effusion, mimicking uveal melanoma, associated with ISCLS following viral infection. Read More

Indian J Ophthalmol 2022 Feb;70(2):710

Glaucoma Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu, India.

Background: Trabeculectomy, a mainstay in the management of glaucoma is associated with various complications, the most dreaded being hypotony.

Purpose: We present a challenging case of late-onset refractory hypotony following trabeculectomy.

Synopsis: : A 64-year-old male patient diagnosed with primary open angle glaucoma in the right eye underwent combined surgery. Read More

Indian J Ophthalmol 2022 Feb;70(2):590-596

Department of Retina and Uvea, Sadguru Netra Chikitsalaya, Madhya Pradesh, India.

Purpose: To determine surgical outcomes and risk factors for failure of trabeculectomy with mitomycin C (TMMC) in pediatric traumatic glaucoma.

Methods: Children who underwent TMMC post trauma from January 2014 to December 2019 were reviewed. Demographic features, ocular findings, and surgery details were noted. Read More

Indian J Ophthalmol 2022 Feb;70(2):443-447

Department of Uveitis and Intraocular Inflammation, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: Chronic uveitis can lead to hypotony that may result in severe visual impairment. We highlight the use of ultrasound biomicroscopy (UBM) as an imaging tool to decide the modality of therapy and management of uveitic hypotony.

Methods: This was a retrospective hospital-based interventional case-series study that included a total of 36 eyes of 25 patients with uveitic hypotony seen between January 1997 and January 2020. Read More

Biomater Sci 2022 Mar 2;10(5):1281-1291. Epub 2022 Mar 2.

National Engineering Research Centre for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P.R. China.

Excessive fibrosis is the major factor in the failure of glaucoma filtration surgery. So far, the dominant approach for inhibiting fibrosis is the use of an antimetabolite drug, but the complications it causes, such as filtering bleb leakage, bacterial endophthalmitis and ocular hypotony, are also inevitable. Herein, a multifunctional anti-scarring platform ([email protected]/5-Fu) integrated with outstanding photothermal, antibacterial and drug delivery abilities is developed. Read More

Int J Ophthalmol 2022 18;15(1):83-88. Epub 2022 Jan 18.

The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Aim: To investigate the incidence, risk factors, clinical course, and outcomes of corneal epithelial defects (CED) following vitreoretinal surgery in a prospective study setting.

Methods: This was a post-hoc analysis of all participants in DISCOVER intraoperative optical coherence tomography study. Subjects with CED 1d after surgery without intraoperative corneal debridement was defined as the postoperative CED group. Read More