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J Ophthalmol 2019 10;2019:3120960. Epub 2019 Jan 10.

Department of Medicine-Ophthalmology, University of Udine, Udine, Italy.

Purpose: To compare the anatomical and visual results and complications of 27-gauge versus 25-gauge transconjunctival sutureless vitrectomy for the management of primary rhegmatogenous retinal detachment.

Methods: A prospective, propensity score-matched 6-month study was performed. All patients underwent either 27-gauge or 25-gauge vitrectomy as the first surgical intervention and were followed up over a 6-month period, in order to evaluate anatomical success, change in best-corrected visual acuity (BCVA), and intraoperative and postoperative complications including intraocular pressure dysregulation. Read More

Exp Gerontol 2019 Jan 22;119:14-24. Epub 2019 Jan 22.

Department of Medical Gerontology, School of Medicine, Trinity College Dublin, The University of Dublin, Old Stone Building, Trinity Centre for Health Sciences, St James's Hospital, James's Street, Dublin 8, Ireland; The Irish Longitudinal Study on Aging (TILDA), Lincoln Gate, Trinity College Dublin, The University of Dublin, College Green, Dublin 2, Ireland. Electronic address:

Background: Hypertension is established to cause vascular end-organ damage. Other forms of dysregulated blood pressure (BP) behaviour, such as orthostatic hypotension have also been associated with cardiovascular (CV) events. The eye is potentially vulnerable to dysregulated systemic BP if ocular circulation autoregulation is impaired. Read More

Acta Cardiol 2019 Jan 16:1-5. Epub 2019 Jan 16.

a Cardiology Department , Baskent University Faculty of Medicine , Ankara , Turkey.

Background: Glaucoma is commonly defined as high intra ocular pressure (≥21 mmHg) with optic neuropathy characterised by progressive loss of retinal ganglion cells which is associated with characteristic structural damage to the optic nerve and visual field loss. There are several studies investigating relation between primary open angle glaucoma (POAG) and both systemic hypertension and especially night hypotension. Our aim was to compare 24-h ambulatory blood pressure variability of patients with glaucoma followed-up in the eye outpatient clinic with that of patients free of glaucoma. Read More

Transl Vis Sci Technol 2019 Jan 3;8(1). Epub 2018 Jan 3.

Department of Biomedical Engineering, The University of Akron, Akron, OH, USA.

Purpose: This study was conducted to investigate changes in intraocular pressure (IOP) in the presence of intravitreal gas bubbles in individuals who travel through subsea tunnels.

Methods: Using a mathematical model, we simulated alterations in ocular globe shape, aqueous humor flow, volume of intravitreal gas bubbles, and IOP due to elevation changes during travel through subsea tunnels. We simulated five tunnels with different features as case studies. Read More

Cornea 2019 Feb;38(2):198-202

Dr. Shroff's Charity Eye Hospital, Daryaganj, New Delhi, India.

Purpose: This study describes the impact of scleral ischemia on globe survival in cases of acute chemical injury and the outcome of limbal stem cell transplant in these eyes.

Methods: This is a single-center, retrospective case study that reviews outcomes in all patients with acute chemical injury of grades IV and above who presented within 6 weeks from injury. The period of the study is between May 2012 and May 2017. Read More

J Glaucoma 2019 Feb;28(2):178-180

Department of Ophthalmology, Rambam Health Care Campus.

Purpose: Subtle folds can be seen in the anterior cornea in eyes with hypotony using fluorescein and blue light. We aim to assess their extent and grade with respect to the level of intraocular pressure (IOP).

Patients And Methods: Patients who presented to the department of ophthalmology at Rambam Health Care Campus with IOP<10 mm Hg during the period between July 2016 and June 2017. Read More

Curr Opin Ophthalmol 2019 Mar;30(2):125-131

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Purpose Of Review: This article reviews recent studies related to tube shunt surgery.

Recent Findings: Medical claims data and surveys of glaucoma surgeons demonstrate that tube shunts are being selected with increasing frequency as an alternative to trabeculectomy. A 5-year pooled analysis of the Ahmed Baerveldt comparison study and Ahmed versus Baerveldt study found a higher rate of surgical success with the Baerveldt glaucoma implant compared with the Ahmed glaucoma valve, but Baerveldt implantation carried a higher risk of hypotony. Read More

Korean J Ophthalmol 2018 Dec;32(6):523-524

Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):918-922

Tianjin Medical University Eye Hospital, College of Optometry and Ophthalmology, Tianjin Medical University Eye Institute, Tianjin 300384, China.

To report the clinical outcomes and safety profile of 27G(+) transconjunctival sutureless vitrectomy (TSV) in eyes with posterior segment disease. Prospective, interventional case series. Eyes undergoing 27G(+) TSV for a vitreoretinal surgery indication were included from Dec 2015 to Mar 2016. Read More

Clin Exp Optom 2018 Nov 22. Epub 2018 Nov 22.

School of Optometry, University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA.

Psychophysiology 2019 Mar 19;56(3):e13305. Epub 2018 Nov 19.

Department of Psychology, University of Bonn, Bonn, Germany.

In addition to symptoms including fatigue, dizziness, reduced drive, or mood disturbance, individuals with chronic low blood pressure (hypotension) frequently report cognitive complaints. While attentional deficits have been empirically confirmed, it is still unknown whether the impairments also encompass executive functions. This study investigated cerebral blood flow modulations in hypotension during a precued antisaccade/prosaccade task requiring the executive function of proactive inhibition in addition to preparatory attention. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Jan 19;257(1):101-109. Epub 2018 Nov 19.

Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop St, Suite 819, Pittsburgh, PA, 15213, USA.

Purpose: This study investigated the hypotensive effect of RKI-1447, a Rho kinase inhibitor, in a porcine ex vivo pigmentary glaucoma model.

Methods: Twenty-eight porcine anterior chambers were perfused with medium supplemented with 1.67 × 10 pigment particles/ml for 48 h before treatment with RKI-1447 (n = 16) or vehicle control (n = 12). Read More

Cont Lens Anterior Eye 2019 Feb 12;42(1):123-126. Epub 2018 Nov 12.

Visser Contact Lens Practice, Sint Annastraat 93, 6524 EJ Nijmegen, the Netherlands. Electronic address:

Purpose: Ocular hypotony after trabeculectomy may be treated medically, surgically and with a tamponade. Three cases are reported in which a scleral lens was applied to treat ocular hypotony after mitomycin C (MMC) augmented trabeculectomy.

Methods: In this retrospective case series the records of three eyes of three patients who developed ocular hypotony after they had undergone trabeculectomy augmented with MMC were evaluated. Read More

Clin Ophthalmol 2018 23;12:2145-2148. Epub 2018 Oct 23.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA,

Purpose: To report the visual outcomes and complications of scleral fixated intraocular lenses (IOLs) using Gore-Tex suture.

Methods: The current study is a retrospective noncomparative case series including patients who underwent scleral fixation of IOL (Akreos AO60) using Gore-Tex suture from August 2015 to March 2017 at a university teaching center. Primary outcome measures were visual acuity and complications at last follow-up. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Jan 9;257(1):125-134. Epub 2018 Nov 9.

Department of Ophthalmology, Ludwig-Maximilians-University Munich, Mathildenstrasse 8, 80336, Munich, Germany.

Purpose: To investigate preoperative ocular risk factors and indications for secondary intraocular lens (IOL) implantation and compare postoperative complications, visual and refractive outcomes in a tertiary referral center.

Methods: Patients older than 14 years that underwent secondary IOL implantation and had a minimum follow-up of 3 months were enrolled in this retrospective case series. Preoperative ocular risk factors, indications for surgery, postoperative complications, and visual and refractive outcomes including prediction error (PE) and absolute error (AE) were evaluated. Read More

J Glaucoma 2019 Jan;28(1):27-31

Department of Ophthalmology, University of Washington, Seattle, WA.

Purpose: The purpose of this study was to assess long-term outcomes and complications of smaller-incision trabeculectomy revision with mitomycin (MMC) in glaucoma patients.

Methods: Review of patients undergoing trabeculectomy revision with MMC for inadequate intraocular pressure (IOP) control. After dissection of subconjunctival fibrosis through a smaller (median, 5 mm) incision, MMC was topically applied and episcleral fibrosis was incised. Read More

Br J Pharmacol 2019 Mar 4;176(5):687-698. Epub 2019 Jan 4.

JeniVision Inc., Irvine, CA, USA.

Background And Purpose: Prostanoid EP receptor agonists exhibit several activities including ocular hypotension, tocolysis and anti-inflammatory activity. This report describes the affinity and selectivity of a structurally novel, non-prostanoid EP receptor agonist, PGN-9856, and its therapeutic potential.

Experimental Approach: The pharmacology of a series of non-prostanoid EP receptor agonists was determined according to functional and radioligand binding studies, mostly using human recombinant prostanoid receptor transfectants. Read More

Medicine (Baltimore) 2018 Oct;97(42):e12676

Department of Interventional Radiology and hemangioma.

Intra-arterial chemotherapy (IAC) has become an essential technique for the management of advanced intraocular retinoblastoma (RB). In this study, the aim of this article is to describe the clinical results and the short-term complications of IAC performed in our hospital.We retrospectively analyzed patients with newly diagnosed unilateral advanced intraocular (group D or E) RB undergoing IAC from October 2016 to December 2017 in our hospital. Read More

Retina 2018 Oct 9. Epub 2018 Oct 9.

Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel.

Purpose: The purpose of this study was to assess the incidence and risk factors for early postoperative hypotony after 25-gauge pars plana vitrectomy with nonexpansile endotamponade.

Methods: A retrospective study of consecutive patients who underwent 25-G pars plana vitrectomy. Hypotony was defined as an intraocular pressure of 5 mmHg or less after surgery and ocular hypertension as an intraocular pressure greater than 21 mmHg. Read More

Eur J Ophthalmol 2018 Oct 7:1120672118803515. Epub 2018 Oct 7.

2 Cornea, Cataract and Refractive Surgery Unit, VISSUM Alicante, Alicante, Spain.

Purpose: To report a new approach for the treatment of severe ocular hypotony secondary to glaucoma filtering surgery with mitomycin C by injecting autologous eye platelet-rich plasma (E-PRP) in the anterior chamber to block excessive diffuse filtration through an abnormally thinned sclera.

Methods: A 49-year-old patient with the Axenfeld-Rieger syndrome and severe chronic hypotony and corneal edema following filtering glaucoma surgery with mitomycin C received an isolated injection of 0.3 mL of autologous platelet-rich plasma in the anterior chamber. Read More

Jpn J Ophthalmol 2018 Nov 6;62(6):621-627. Epub 2018 Oct 6.

Hayashi Eye Hospital, 4-23-35 Hakataekimae, Hakata-ku, Fukuoka, 812-0011, Japan.

Purpose: To compare the intraocular pressure (IOP) and wound state immediately after cataract surgery for eyes with a long clear corneal incision (CCI) with those for eyes with a short CCI.

Study Design: Randomized clinical trial.

Methods: One hundred twenty-eight eyes of 128 patients scheduled for phacoemulsification were randomly assigned to undergo long (≥ 1. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Dec 29;256(12):2369-2376. Epub 2018 Sep 29.

Department of Ophthalmology and Vision Science, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Rd., Shanghai, 200031, China.

Purpose: To evaluate the surgical outcomes of cyclodialysis cleft repair and cataract management by phacoemulsification combined with internal tamponade using a modified capsular tension ring (MCTR) compared with direct cyclopexy.

Methods: The preoperative and postoperative characteristics of patients with cyclodialysis clefts who underwent surgery via insertion of an MCTR into the ciliary sulcus (MCTR group; 16 patients, 16 eyes) or direct cyclopexy (DC group; 16 patients, 16 eyes) were recorded.

Results: The cyclodialysis extended over 2. Read More

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):222. Epub 2018 Sep 14.

Western Eye Hospital, London, UK.

Background: The surgical management of patients with uncontrolled glaucoma and scleroderma is challenging, as the hostile ocular surface poses a challenge to surgery. A serious complication is tube erosion, with the risk of subsequent endophthalmitis. Here, we present a novel technique of harvesting autologous tissue to successfully manage recurrent tube extrusion. Read More

Indian J Ophthalmol 2018 Oct;66(10):1429-1434

Guru Nanak Eye Centre, New Delhi, India.

Purpose: To report long-term safety and efficacy of trabeculectomy with collagen implant in Indian population.

Methods: All cases of trabeculectomy with Ologen Collagen Matrix implant performed over a 7-year period from May 2008 through April 2015 at a tertiary referral institute were reviewed. A total of 30 eyes of 28 patients were included in the study with two patients undergoing bilateral trabeculectomy. Read More

Interv Neuroradiol 2018 Sep 23:1591019918800220. Epub 2018 Sep 23.

3 Department of Radiology, Bumrungrad International Hospital, Bangkok, Thailand.

Spontaneous regression of direct carotid-cavernous fistulas (CCFs) is extremely rare. Most of the patients with direct CCFs are usually treated using endovascular techniques. Spontaneous obliteration of the direct fistulas probably results from thrombosis of the venous drainage and/or cavernous sinus. Read More

J Ophthalmol 2018 29;2018:3212740. Epub 2018 Aug 29.

Department of Vitreo-Retinal Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, 1 Anna Nagar, Madurai, Tamil Nadu 625020, India.

Aim: This paper aims at evaluating refractive outcome and complication profile of sutureless, glueless, flapless, intrascleral fixation of intraocular lens (SFIOL) in pediatric population.

Methods: This retrospective study included patients ≤18 years of age who underwent SFIOL for ectopia lentis. Details obtained included preoperative uncorrected visual acuity (UCVA), cycloplegic refraction, and best-corrected visual acuity (BCVA); intraoperative complications; and postoperative UCVA, cycloplegic refraction, and BCVA and complications. Read More

Int J Retina Vitreous 2018 5;4:29. Epub 2018 Sep 5.

1Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, 500034 India.

Background: The close structural and microcirculatory co-relation between anterior and posterior segments of eye make them very vulnerable to complications when one of them is affected surgically. With the advent of anti-fibrotic agents in the management of glaucoma, the rates of vitreoretinal complications have become more frequent.

Main Body: Common retinal complications after glaucoma surgeries include choroidal detachment; ocular decompression retinopathy; haemorrhagic choroidal detachment; hypotony maculopathy; malignant glaucoma; vitreous haemorrhage; bleb endophthalmitis; retinal detachment. Read More

Eur J Ophthalmol 2019 Jan 3;29(1):NP6-NP9. Epub 2018 Sep 3.

2 Cornea, Cataract and Refractive Surgery Unit, Vissum Corporación, Alicante, Spain.

Introduction:: To report the case of a high hyperopic refractive shift associated with significant shortening of the ocular axial length following glaucoma filtering surgery.

Methods:: Case report. Patient's records were consulted retrospectively. Read More

Rev Med Chil 2018 May;146(5):665-669

Departamento de Ciencias Neurológicas Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Upgaze or sustained elevation of the eyes, is an alteration of ocular motility initially described in hypoxic coma. We report a 65-year-old woman admitted with hypotension and alteration of sensorium due to the ingestion of 9.5 g of Bupropion. Read More

J Fr Ophtalmol 2018 Sep 20;41(7):611-618. Epub 2018 Aug 20.

Ophthalmology department, institut du Glaucome, centre hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75674 Paris cedex 14, France.

Purpose: To compare the efficacy of two cyclodestructive treatments for refractory glaucoma: High Intensity Focused Ultrasound (HIFU) cyclocoagulation and transscleral diode laser cyclophotocoagulation (cyclodiode).

Methods: A retrospective comparative single centre study including all patients who underwent cyclodestruction for refractory glaucoma by either HIFU cyclocoagulation or cyclodiode. "Refractory glaucoma" was defined as an uncontrolled high IOP despite medical treatment and at least one filtering surgery. Read More

Br J Ophthalmol 2018 Jul 18. Epub 2018 Jul 18.

Department of Preventive Ophthalmology, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: To analyse the functional and anatomical outcomes of different types of keratoprostheses in eyes with retained silicone oil following vitreoretinal surgery.

Methods: Retrospective chart review of patients operated with any type of permanent keratoprosthesis (Kpro) in silicone oil-filled eyes between March 2003 and June 2017 were analysed.. Read More

Retina 2018 Jul 13. Epub 2018 Jul 13.

Cincinnati Eye Institute, Cincinnati, Ohio.

Purpose: To demonstrate a novel technique to measure the intraocular pressure in silicone oil (SO)-filled eyes with Boston Type 1 keratoprosthesis (KPro) during intraocular surgery.

Methods: In this retrospective case series, an ocular manometer that is predicated on a continuous fluid column between a pressure sensor and interior of the eye was designed and used to directly measure intraocular pressure during intraocular surgery in SO-filled eyes with KPro.

Results: Six eyes of six patients were included in the study. Read More

Lasers Med Sci 2019 Feb 29;34(1):11-14. Epub 2018 Jun 29.

Department of Ophthalmology, Kayseri Research and Training Hospital, Kayseri, Turkey.

To investigate whether ocular hypotony formation with 360 degrees endocyclophotocoagulation is possible. Twelve male New Zealand White rabbits were used. Entire ciliary body epithelium was destructed with green laser photocoagulation after pars plana lensectomy and anterior vitrectomy in six rabbits. Read More

Indian J Ophthalmol 2018 07;66(7):1006-1008

Department of Rheumatology, Apollo Hospital, Chennai, Tamil Nadu, India.

A 42-year-old male presented to us after an episode of acute anterior human leukocyte antigen (HLA)-B27-associated uveitis, and intraocular pressure (IOP) in the right eye was 4 mmHg. Ultrasound biomicroscopy revealed ciliary body edema with supraciliary effusion. He was on a frequent topical corticosteroid, and oral steroid in addition to receiving a periocular injection depot corticosteroid 20 days back. Read More

Z Rheumatol 2018 Jun 20. Epub 2018 Jun 20.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Objective: The aim of this study was to assess disease characteristics, autoantibodies, and disease activity in granulomatosis with polyangiitis (GPA) patients with ocular manifestations.

Methods: The cohort included 46 GPA patients visiting the ophthalmology clinic. Ocular manifestations were recorded, clinical and slit lamp examinations were performed. Read More

Neurol Sci 2018 Jun;39(Suppl 1):25-31

Neuro-ophthalmology and Ocular Electrophysiology Center, Department of Ophthalmology, Scientific Institute Capitanio Hospital, Istituto Auxologico Italiano Foundation, Via Mercalli, 28, 20122, Milan, Italy.

Pain occurs with optic neuropathies associated with inflammatory central nervous system diseases (MS and NMO), idiopathic intracranial hypertension and spontaneous hypotension, giant cell arteritis, immunomediated systemic diseases, compressive lesions, or infective disorders. Pain can precede the onset of visual loss in acute optic neuritis, it can be irradiated to the orbital region in giant cell arteritis and parasellar compressive optic neuropathies, or it may be located to the back of the eye with posterior scleritis. History of symptoms together with complete neuro-ophthalmological examination must guide the differential diagnosis and neuroimaging. Read More

Semin Ophthalmol 2018 14;33(6):788-803. Epub 2018 Jun 14.

a Department of Ophthalmology, Dr. Rajendra Prasad Centre for ophthalmic sciences , All India Institute of Medical Sciences , New Delhi , India.

Phthisis bulbi denotes end-stage eye disease characterized by shrinkage and disorganization of the eye with the resultant functional loss. The major factors associated with the pathogenesis of phthisis are hypotony, deranged blood-ocular barriers, and inflammation. Common causes include trauma, surgery, infection, inflammation, malignancy, retinal detachment, and vascular lesions. Read More

Ophthalmic Genet 2018 Aug 14;39(4):532-538. Epub 2018 Jun 14.

a Department of Ophthalmology, San Raffaele Scientific Institute , Vita-Salute University , Milan , Italy.

Background: 22q11.2 microduplication is a relatively recently recognized syndrome. Findings in affected individuals range from apparent normality to a wide variety of systemic and ocular conditions. Read More

Orv Hetil 2018 Jun;159(24):985-990

Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Mária u. 39., 1085.

We present cases of blinding spontaneous suprachoroidal haemorrhage in anticoagulant taking wet-AMD patients. A retrospective study has been performed to present the clinical course, management and final outcome of spontaneous suprachoroidal haemorrhage in 7 eyes of six age-related macular degeneration patients seen in our clinic from January 2016 to April 2017. All patients were on chronic oral anticoagulant therapy because of cardiovascular disorder. Read More

Eur J Ophthalmol 2018 Nov 11;28(6):731-734. Epub 2018 Jun 11.

Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Purpose:: Over-filtration is a well-known complication of trabeculectomy and related procedures, especially with adjunctive antimetabolites. Secondary hypotony can result in reduced visual acuity and compromise long-term surgical success. Persistent hypotony requires intervention and we describe an effective adaptation of placing conjunctival compression sutures directly over the scleral flap. Read More

Arch Soc Esp Oftalmol 2018 Sep 26;93(9):451-453. Epub 2018 May 26.

Servicio de Oftalmología, Fundación Hospital de Jove, Gijón, Asturias, España.

Clinical Case: A 63-year-old man presents with late hypotony maculopathy after non-penetrating deep sclerectomy. Hypotonia and visual acuity are improved after transconjunctival suturing of the scleral flap.

Discussion: Hypotony maculopathy may occur as a late complication after glaucoma surgery. Read More

Am J Ophthalmol Case Rep 2018 Jun 19;10:290-292. Epub 2018 Apr 19.

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.

Purpose: To report a case of temporary bilateral corneal denting in a patient who underwent cardiovascular surgery under general anesthesia.

Observations: A 71-year-old male with no history of ophthalmological disease experienced bilateral corneal denting immediately after undergoing surgery for aneurysm of the thoracic aorta under general anesthesia. Anesthesia was induced with propofol and maintained with rocuronium bromide and remifentanil hydrochloride. Read More

Horm Res Paediatr 2018 May 4:1-5. Epub 2018 May 4.

Background: Hashimoto thyroiditis (HT) is uncommon in infancy, and myxedema coma (MC) is even less common. While prior reports have documented these entities separately, to our knowledge, MC in combination with HT has not been reported before in this age group.

Methods/results: A 10-month-old female presented with ptosis, lethargy, dysphagia, and failure to thrive (FTT). Read More

Int J Biol Macromol 2018 Sep 30;116:648-663. Epub 2018 Apr 30.

Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India. Electronic address:

Purpose: Enhancing the ocular hypotensive effect of forskolin (FK) by means of biodegradable chitosan (CS) coated poly lactic-co-glycolic acid (PLGA) nanoparticles (NP's).

Methods: One step emulsion-sonication process was employed for the formulation of CS-PLGA NP's with optimization being carried out by employing a four factor four level Box Behnken Design. The physical and spectral characterization, drug release, permeation, confocal and ocular tolerance studies (ex-vivo &in vivo) were performed. Read More

BMC Ophthalmol 2018 Apr 23;18(1):108. Epub 2018 Apr 23.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: To evaluate the safety and efficacy of combined 23-gauge transconjunctival pars plana vitrectomy and scleral fixation of intraocular lens (IOL) without conjunctival dissection.

Methods: A retrospective study in Chang Gung Memorial Hospital, Keelung and Taoyuan, Taiwan. Patients receiving combined 23-gauge transconjunctival pars plana vitrectomy and scleral fixation of IOL without conjunctival dissection were enrolled. Read More

Eur J Ophthalmol 2019 Jan 24;29(1):110-112. Epub 2018 Apr 24.

Davinci Eye Clinic, Tbilisi, Georgia.

Aim:: To describe a novel technique for sutureless hermetic closure of leaking scleral wounds in micro-incision vitreous surgery.

Methods:: This study is a two-centre, non-comparative, interventional case series. We studied 1240 scleral incisions on 870 eyes using different gauges (20, 23, 25) to evaluate the effectiveness of a new technique to seal scleral wounds without sutures. Read More

Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):192-199. Epub 2018 Apr 23.

Singapore National Eye Centre, Singapore.

Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Read More

J Pediatr Neurosci 2017 Oct-Dec;12(4):360-362

Ophthalmology Unit, Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.

This report details two novel mutations causing Warburg Micro syndrome, a rare autosomal recessive disorder characterized by multiple organ abnormalities involving the ocular, nervous, and endocrine systems. Two Italian sisters were referred to our department for the assessment of congenital bilateral cataracts. They also presented with microphthalmia, postnatal microcephaly, severe developmental delay, and hypotony. Read More

Ocul Immunol Inflamm 2018 Apr 19:1-4. Epub 2018 Apr 19.

b Department of Ophthalmology , Warrington & Holton Hospitals NHS Foundation Trust, Lovely Lane , Warrington , UK.

Purpose: To describe the presentation and management of severe ocular adverse events following treatment with pembrolizumab for cutaneous metastatic melanoma.

Methods: Interventional case report.

Results: A 73-year-old Caucasian man receiving pembrolizumab treatment for metastatic melanoma presented with panuveitis and subsequent profound hypotony, choroidal effusions, and optic disk swelling bilaterally. Read More

Surv Ophthalmol 2018 Sep - Oct;63(5):694-699. Epub 2018 Apr 9.

Department of Ophthalmology, Geneva University Hospitals and School of Medicine, Geneva, Switzerland.

Occult globe rupture is a traumatic dehiscence of the sclera at or posterior to the rectus muscle insertions without a visible eye wall defect on slit lamp examination. Occult scleral ruptures are important because they can be difficult to diagnose, but normally require preoperative protection against external pressure to reduce risk of herniation of ocular contents through the rupture and then urgent surgical repair to restore eye wall structural integrity and achieve optimum prognosis. A deeper-than-normal anterior chamber with posteriorly retracted plateau iris seen immediately after acute ocular trauma is virtually pathognomonic of posterior globe dehiscence. Read More