54,698 results match your criteria Ocular Hypertension


Relationship between primary open angle glaucoma and blood pressure.

Acta Cardiol 2019 Jan 16:1-5. Epub 2019 Jan 16.

a Cardiology Department , Baskent University Faculty of Medicine , Ankara , Turkey.

Background: Glaucoma is commonly defined as high intra ocular pressure (≥21 mmHg) with optic neuropathy characterised by progressive loss of retinal ganglion cells which is associated with characteristic structural damage to the optic nerve and visual field loss. There are several studies investigating relation between primary open angle glaucoma (POAG) and both systemic hypertension and especially night hypotension. Our aim was to compare 24-h ambulatory blood pressure variability of patients with glaucoma followed-up in the eye outpatient clinic with that of patients free of glaucoma. Read More

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http://dx.doi.org/10.1080/00015385.2018.1549004DOI Listing
January 2019

[Long-term outcome of bilateral surgery in infant with congenital cataract using different approaches].

Zhonghua Yan Ke Za Zhi 2019 Jan;55(1):46-50

Department of Ophthalmology, Peking University People's Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100044, China.

To explore the best surgical approach for infant with congenital cataract by comparing long-term follow-up results of bilateral congenital cataract surgery by different approaches conducted during infant age at last time of visit. This retrospective case control study includes 108 eyes of 54 infants with bilateral congenital cataract who received bilateral cataract triple procedure (vitrector lensectomy, posterior capsulotomy and anterior vitrectomy) performed by a single surgeon, by either anterior or posterior approach, followed by refractive correction by aphakic glasses or intraocular lens (if suitable)during the follow-up periods (at least for 3 years), between January 2002 and February 2013 in Department of Ophthalmology, Peking University People's Hospital. The unilateral and bilateral best corrected visual acuity (BCVA), intraocular pressure, anterior segment and fundus exam of each visit and post-operative complications were evaluated, and data collected at patients' last visit were compared between two approaches (Student's test for continuous variables, chi-squeare test for constitutional variables). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.01.009DOI Listing
January 2019

Mouse model of ocular hypertension with retinal ganglion cell degeneration.

PLoS One 2019 14;14(1):e0208713. Epub 2019 Jan 14.

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America.

Objectives: Ocular hypertension is a primary risk factor for glaucoma and results in retinal ganglion cell (RGC) degeneration. Current animal models of glaucoma lack severe RGC cell death as seen in glaucoma, making assessment of physiological mediators of cell death difficult. We developed a modified mouse model of ocular hypertension whereby long-lasting elevation of intraocular pressure (IOP) is achieved, resulting in significant reproducible damage to RGCs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208713PLOS
January 2019
1 Read

Activation of Nrf2/HO-1 pathway protects retinal ganglion cells from a rat chronic ocular hypertension model of glaucoma.

Int Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China.

Objective: The objective of this work was to find out the effects of nuclear factor erythroid 2-related factor/heme oxygenase-1 (Nrf2/HO-1) pathway on retinal ganglion cell (RGC) injury in glaucoma.

Methods: The chronic ocular hypertension (COH) rat models of glaucoma were constructed, and intraocular pressure (IOP) and RGC numbers were detected at different time points. Additionally, rats were divided into normal group (normal control rats), model group (COH model rats), and model + tBHQ group (COH model rats treated with Nrf activator, tBHQ). Read More

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http://dx.doi.org/10.1007/s10792-018-01071-8DOI Listing
January 2019

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018
4 Reads

Ocular hypertension secondary to high endogenous steroid load in Cushing's disease.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Ophthalmology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.

This case report describes a 35-year-old Caucasian man who was referred to the glaucoma clinic with high intraocular pressure (IOP) after routine optometrist assessment. He was diagnosed with ocular hypertension (OHT) and the management plan was for monitoring without treatment. Three months later, he presented to the endocrine clinic with symptoms of Cushing's disease and was diagnosed with an adrenocorticotropic hormone secreting pituitary microadenoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-226738DOI Listing
January 2019

Methyl 3,4-dihydroxybenzoate protects retina in a mouse model of acute ocular hypertension through multiple pathways.

Exp Eye Res 2019 Jan 8. Epub 2019 Jan 8.

Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, 510632, China; Co-Innovation Center of Neuroregeneration, Nantong University, Jiangsu, China. Electronic address:

Methyl 3,4 dihydroxybenzoate (MDHB) is a small molecule that shows neuroprotective effects in vitro and in a photoreceptor-degenerative mouse model. Here we investigated whether MDHB protects retina in a mouse model of acute ocular hypertension (AOH) and explores the underlying mechanisms. AOH was induced in mice by increasing intraocular pressure to approximately 90 mmHg for 60 min, then MDHB or vehicle was intraperitoneally injected daily up to 7 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183067
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http://dx.doi.org/10.1016/j.exer.2019.01.010DOI Listing
January 2019
3 Reads

Self-measurement with Icare HOME tonometer, patients' feasibility and acceptability.

Eur J Ophthalmol 2019 Jan 11:1120672118823124. Epub 2019 Jan 11.

3 University Eye Clinic, Skopje, Republic of Macedonia.

Purpose:: To evaluate and compare the accuracy of self-measurement of intraocular pressure using Icare Home rebound tonometer with Goldmann applanation tonometer and assess acceptability of self-tonometry in patients with glaucoma and ocular hypertension.

Methods:: In the study, 117 subjects were trained to use Icare Home for self-measurement. Icare Home tonometer readings were compared with Goldmann applanation tonometer, including one eye per patient. Read More

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http://dx.doi.org/10.1177/1120672118823124DOI Listing
January 2019

Association between early-stage chronic kidney disease and reduced choroidal thickness in essential hypertensive patients.

Hypertens Res 2019 Jan 10. Epub 2019 Jan 10.

Unit of Nephrology and Hypertension, Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), European Society of Hypertension Excellence Centre, Università degli studi di Palermo, Palermo, Italy.

The introduction in the past few years of advanced optical coherence tomography (OCT) techniques has greatly increased our understanding of the choroid, which is the most important vascular layer of the eye. Our study aimed to assess choroidal thickness by using swept-source OCT (SS-OCT) in essential hypertensive patients (EHs) with and without early-stage chronic kidney disease (CKD). We enrolled 100 EHs, of whom 65 were without kidney damage, and 35 had stage 1-3 CKD. Read More

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http://www.nature.com/articles/s41440-018-0195-1
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http://dx.doi.org/10.1038/s41440-018-0195-1DOI Listing
January 2019
1 Read

Optical Coherence Tomography Angiography of Optic Disc in Eyes with Primary Open-angle Glaucoma and Normal-tension Glaucoma.

J Glaucoma 2019 Jan 7. Epub 2019 Jan 7.

Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.

Purpose: To examine vessel density (VD) properties of the optic nerve head (ONH) in eyes with ocular hypertension (OHT), high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) and to evaluate associations on structural parameters of retinal nerve fiber layer (RNFL).

Methods: Three groups of patients with OHT (n=15), HTG (n=36) and NTG (n=22), and a healthy control group (n=23) were included in this study. Peripapillary VD and optic disc flow area were measured using optical coherence tomography angiography, and peripapillary RNFL thickness was determined. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001184DOI Listing
January 2019

Urrets-Zavalia syndrome with interface fluid syndrome following laser in situ keratomileusis.

Am J Ophthalmol Case Rep 2019 Mar 18;13:96-98. Epub 2018 Dec 18.

Cornea and External Disease Department, Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, EC1V 2PD, London, UK.

Purpose: We describe the case of a 41-year-old male that underwent laser in situ keratomileusis (LASIK) complicated by Urrets-Zavalia syndrome with interface fluid syndrome and epithelial ingrowth.

Observation: The patient presented at our institution with headache and blurred vision three weeks after a right microkeratome-assisted LASIK procedure. On examination, the visual acuity was hand movements and the intraocular pressure (IOP) was 45 mmHg with fluid in the flap interface, a fixed pupil in moderate mydriasis, iris transillumination and cells in the anterior chamber. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183030
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http://dx.doi.org/10.1016/j.ajoc.2018.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305690PMC
March 2019
3 Reads

Ex-PRESS mini-shunt implanted in a pregnant patient with iridocorneal endothelial syndrome.

Eur J Ophthalmol 2019 Jan 8:1120672118820508. Epub 2019 Jan 8.

Ophthalmology Department, Tajo Hospital, Aranjuez, Spain.

Introduction:: The failure rate of both filtration surgery and of aqueous shunt implantation is higher for iridocorneal endothelial syndrome than in other scenarios, due to the continuous proliferation of abnormal endothelial cells over the trabecular meshwork and the filtration area and also due to the more pronounced cicatrizing response shown by these young patients. We present the first case ever described in the literature of a pregnant patient with iridocorneal endothelial syndrome and uncontrolled ocular hypertension who was implanted an Ex-PRESS mini-shunt.

Clinical Case:: A 35-year-old female presented with diminution of vision in the left eye for 2 months. Read More

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http://dx.doi.org/10.1177/1120672118820508DOI Listing
January 2019

Correction to: Multicenter, Randomized, Controlled Study Comparing Tafluprost/Timolol Fixed Combination with Latanoprost/Timolol Fixed Combination in Primary Open-Angle Glaucoma and Ocular Hypertension.

Adv Ther 2019 Jan 8. Epub 2019 Jan 8.

Fukushima Eye Clinic, Osaka, Japan.

In the original publication, the range to derive the P values is incorrectly represented in Table 2 and Table 3. The corrected tables are provided below. Read More

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http://dx.doi.org/10.1007/s12325-018-0864-0DOI Listing
January 2019

Latanoprostene bunod ophthalmic solution 0.024%: a new treatment option for open-angle glaucoma and ocular hypertension.

Clin Exp Optom 2019 Jan 7. Epub 2019 Jan 7.

Schwartz Laser Eye Center, Scottsdale, Arizona, USA.

Latanoprostene bunod (LBN) ophthalmic solution 0.024% is a novel, once-daily, nitric oxide-donating prostaglandin analogue for the lowering of intraocular pressure (IOP) in patients with open-angle glaucoma and ocular hypertension. The IOP-lowering actions of LBN are mediated by dual mechanisms of the molecule for increasing aqueous humour outflow. Read More

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http://dx.doi.org/10.1111/cxo.12853DOI Listing
January 2019

Novel gene mutation in a Chinese family with primary open-angle glaucoma.

Br J Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China

Purpose: To characterise the genotype(s), phenotype(s) and age-related penetrance of glaucoma in a Chinese family with primary open-angle glaucoma (POAG).

Methods: Recruited from a Chinese family spanning four generations, 7 individuals with POAG, 1 with ocular hypertension (OHT) and 14 unaffected individuals were included in this study. Genotypic investigation included sequencing of mutation sites using a glaucoma panel in combination with high-throughput sequencing and validated using Sanger sequencing. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313069DOI Listing
January 2019
1 Read

Safety and Efficacy of Ripasudil in Japanese Patients with Glaucoma or Ocular Hypertension: 3-month Interim Analysis of ROCK-J, a Post-Marketing Surveillance Study.

Adv Ther 2019 Jan 4. Epub 2019 Jan 4.

Post Marketing Surveillance Department, Kowa Company, Ltd., Tokyo, Japan.

Introduction: To evaluate the safety and intraocular pressure (IOP)-lowering effects of a ripasudil 0.4% ophthalmic solution in Japanese patients with glaucoma and ocular hypertension (OH) as a post-marketing surveillance.

Methods: This was a 2-year prospective observational study in patients with glaucoma or OH who had not previously received ripasudil. Read More

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http://dx.doi.org/10.1007/s12325-018-0863-1DOI Listing
January 2019

Long-term probability of intraocular pressure elevation with the intravitreal dexamethasone implant in the real-world.

PLoS One 2019 4;14(1):e0209997. Epub 2019 Jan 4.

Institut Clínic d´Oftalmología (ICOF), Hospital Clinic, Barcelona, Spain.

Purpose: To evaluate the long-term cumulative probability of intraocular pressure (IOP) elevation with the intravitreal dexamethasone implant (IDI) when used to treat different indications: diabetic macular edema, uveitis, retinal vein occlusion.

Methods: 705 IDI injections (429 eyes) were assessed and Kaplan-Meier graphs were generated to assess: the probability of different levels of IOP elevation (IOP≥21, ≥25 or ≥35 mmHg), IOP change ≥10 mmHg, initiation of IOP-lowering treatment, glaucoma surgery, IOP change with repeat injections and IOP elevation in eyes with glaucoma and ocular hypertension (OHT).

Results: The cumulative probability of IOP ≥21, ≥25 and ≥35 mmHg was 50%-60%, 25%-30% and 6%-7% at 12-24 months, respectively. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209997PLOS
January 2019
1 Read

The association between prelaminar tissue thickness and peripapillary choroidal thickness in untreated normal-tension glaucoma patients.

Medicine (Baltimore) 2019 Jan;98(1):e14044

Department of Ophthalmology, Korea University College of Medicine, Seoul.

To evaluate the association between prelaminar tissue thickness (PLT) and peripapillary choroidal thickness (PCT) in untreated normal-tension glaucoma (NTG) patients.A cross-sectional study was conducted in 65 untreated NTG patients. All of the subjects were imaged with swept-source optical coherence tomography (SS-OCT, DRI OCT; Topcon, Tokyo, Japan) to obtain the horizontal scan crossing the optic nerve head center. Read More

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http://dx.doi.org/10.1097/MD.0000000000014044DOI Listing
January 2019
5.723 Impact Factor

Efficacy of a Novel Retrobulbar Extension Shunt to Rescue Eyes with Fibrotic Encapsulated Blebs and Uncontrolled Ocular Hypertension.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 3. Epub 2019 Jan 3.

University of Texas Health Science Center at San Antonio Long School of Medicine, San Antonio, TX, USA.

Purpose: Retrobulbar glaucoma shunts are large-bore fenestrated silicone stents that redirect aqueous humor into the retrobulbar space. They were designed to rescue failed standard tube shunts with fibrotic encapsulation in patients with intractable ocular hypertension. This article evaluates longer-term outcomes of a larger population undergoing retrobulbar aqueous redirection. Read More

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http://dx.doi.org/10.1007/s00417-018-4186-3DOI Listing
January 2019
1 Read

Evidence of Hypoxic Glial Cells in a Model of Ocular Hypertension.

Invest Ophthalmol Vis Sci 2019 Jan;60(1):1-15

Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, United States.

Purpose: Reoxygenation after hypoxia can increase reactive oxygen species and upregulate autophagy. We determined, for the first time, the impact of elevated IOP on hypoxia induction, superoxide accumulation, and autophagy in a bead model of glaucoma.

Method: Ocular hypertension was achieved with magnetic bead injection into the anterior chamber. Read More

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http://dx.doi.org/10.1167/iovs.18-24977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322635PMC
January 2019

Latanoprostene bunod ophthalmic solution 0.024% in the treatment of open-angle glaucoma: design, development, and place in therapy.

Clin Ophthalmol 2018 20;12:2649-2657. Epub 2018 Dec 20.

Division of Glaucoma, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA,

Latanoprostene bunod (LBN) 0.024%, a modified prostaglandin analog, was approved on November 2, 2017, for the reduction of IOP in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). LBN works by combining the IOP-lowering effects of the prostaglandin analogs (through the uveoscleral pathway) with nitric oxide-induced relaxation of the trabecular meshwork and Schlemm's canal. Read More

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https://www.dovepress.com/latanoprostene-bunod-ophthalmic-so
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http://dx.doi.org/10.2147/OPTH.S156038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304237PMC
December 2018
2 Reads

Diurnality, Type 2 Diabetes, and Depressive-Like Behavior.

J Biol Rhythms 2018 Dec 25:748730418819373. Epub 2018 Dec 25.

School of Zoology, Tel-Aviv University, Tel Aviv, Ramat Aviv, Israel.

Although type 2 diabetes (T2DM) and depression are associated with disturbances in circadian rhythms, most studies of these diseases use nocturnal mice and rats while modeling diurnal humans. We suggest that the development of T2DM and depression are related to changes that accompany the switch from the mammalian ancestral nocturnal activity to the current diurnal one. We show that diurnal sand rats ( Psammomys obesus) held outdoors in laboratory cages (where they are exposed to natural environmental conditions) and fed a standard rodent diet do not develop T2DM in contrast to animals held indoors (where the only cycling environmental condition is light) fed the same diet. Read More

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http://dx.doi.org/10.1177/0748730418819373DOI Listing
December 2018
1 Read

The Current Status of Glaucoma and Glaucoma Care in Sub-Saharan Africa.

Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec;7(6):375-386

Department of Ophthalmology, Ahmadu Bello University, Zaria, Nigeria.

Glaucoma is a serious and irreversibly blinding eye condition of public health importance in Africa. The absence of distinct early symptoms makes the condition hard to recognize by patients. The gradual vision deterioration that occurs is worse in one eye, thereby making it difficult for those affected to be aware of the vision loss until the advanced stages of the disease. Read More

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http://dx.doi.org/10.22608/APO.2018392DOI Listing
December 2018

Therapeutic efficacy of latanoprost on primary open angle glaucoma: A protocol for a systematic review of randomized controlled trial.

Medicine (Baltimore) 2018 Dec;97(51):e13833

Department of Research, The Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China.

Background: Latanoprost is quiet new formulation that is approved for the treatment of primary open angle glaucoma (POAG). However, no updated systematic review has addressed its efficacy for POAG. This systematic review of randomized controlled trials (RCTs) aims to assess its efficacy and safety for the treatment of patients with POAG. Read More

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http://dx.doi.org/10.1097/MD.0000000000013833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320140PMC
December 2018

Do we need day-1 postoperative follow-up after cataract surgery?

Graefes Arch Clin Exp Ophthalmol 2018 Dec 19. Epub 2018 Dec 19.

Hygeia Clinic, Gdańsk, Poland.

Purpose: The aim of our study was to evaluate the current nature and frequency of complications present on the first postoperative day (POD1) and to verify whether the completion of a follow-up visit at this time is justified after standard phacoemulsification cataract surgery (PCS).

Methods: We used the PubMed literature database to identify relevant studies using the following keywords: postoperative, follow-up visit, complications, outcome, intraocular pressure, IOP, intraocular pressure spikes, IOP spikes, wound leakage, wound dehiscence, intraocular lens, IOL, dislocation, exchange, phacoemulsification, cataract surgery, and cataract extraction.

Results: We collected and analyzed 45 articles published between 1994 and 2017. Read More

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http://dx.doi.org/10.1007/s00417-018-04210-0DOI Listing
December 2018
1 Read

Neuronal apoptosis, axon damage and synapse loss occur synchronously in acute ocular hypertension.

Exp Eye Res 2018 Dec 16;180:77-85. Epub 2018 Dec 16.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China. Electronic address:

Retinal ganglion cells (RGCs) apoptosis and their axon degeneration are pivotal features in glaucoma. Previous studies suggest that the process of RGCs soma degeneration is distinct from axon degeneration and that both of them lead to vision loss but separately. However, since a normal visual function relies on the integrity of axon, synapse and soma in the retina, a comprehensive understanding of the changes of these neuron components in glaucoma is desired. Read More

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http://dx.doi.org/10.1016/j.exer.2018.12.006DOI Listing
December 2018

[Microinvasive glaucoma surgery-Efficacy of trabecular stents in combined interventions : A clinical study on 65 eyes].

Ophthalmologe 2018 Dec 17. Epub 2018 Dec 17.

Augenklinik und Augenlaserklinik Mainfranken, Am Oberen Marienbach 1, 97421, Schweinfurt, Deutschland.

Background And Objective: In this prospective randomized simple blind study, we investigated the long-term results of trabecular micro-bypass stent implantation as part of routine cataract surgery in eyes with primary chronic open-angle glaucoma. The chamber angle implants drain between the anterior chamber and the canal of Schlemm and circumvent the main outflow resistance by the trabecular meshwork.

Patients And Methods: The study included 65 eyes from 56 patients with primary chronic open-angle glaucoma with at least 2 different pressure-lowering drugs. Read More

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http://dx.doi.org/10.1007/s00347-018-0824-8DOI Listing
December 2018

Juvenile open-angle Glaucoma associated with Leber's hereditary optic neuropathy: a case report and literature review.

BMC Ophthalmol 2018 Dec 17;18(1):323. Epub 2018 Dec 17.

Department of Ophthalmology, Chang-Gung Memorial Hospital, 222 Mai-Chin Rd, Keelung, 204, Taiwan (Republic of China).

Background: Leber's hereditary optic neuropathy (LHON) is a maternally inherited recessive disease rarely complicated with glaucoma. We conducted a clinical and genetic retrospective case series to describe three cases of juvenile open-angle glaucoma (JOAG) and an ND4 m11778G > A mitochondrial DNA (mtDNA) mutation, which is pathognomonic for LHON.

Case Presentation: Patient 1 was a 16-year-old boy diagnosed with bilateral JOAG and high myopia. Read More

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http://dx.doi.org/10.1186/s12886-018-0980-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296145PMC
December 2018

Can Artificial Intelligence Make Screening Faster, More Accurate, and More Accessible?

Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec;7(6):436-441. Epub 2018 Dec 17.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Diabetic retinopathy, glaucoma, and age-related macular degeneration are leading causes of vision loss and blindness worldwide. They tend to be asymptomatic in the early phase of disease and therefore require active screening programs to identify the patients requiring referral and treatment. Deep learning-based artificial intelligence technology has recently become a major topic in the field of ophthalmology. Read More

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http://dx.doi.org/10.22608/APO.2018438DOI Listing
December 2018

Dexamethasone implantation in birdshot chorioretinopathy - long-term outcome.

Int Med Case Rep J 2018 30;11:349-358. Epub 2018 Nov 30.

Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA,

Purpose: To evaluate the long-term efficacy of the 0.70 mg dexamethasone (DEX) intravitreal implant in patients with birdshot chorioretinopathy (BSCR).

Methods: Retrospective descriptive case series of BSCR patients treated with DEX implant (DEX implant 0. Read More

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http://dx.doi.org/10.2147/IMCRJ.S164206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280912PMC
November 2018

Subconjunctival draining minimally-invasive glaucoma devices for medically uncontrolled glaucoma.

Cochrane Database Syst Rev 2018 Dec 16;12:CD012742. Epub 2018 Dec 16.

Ophthalmology, Nottingham University Hospital, Derby Road, Nottingham, UK, NG7 2UH.

Background: Glaucoma is a leading cause of irreversible blindness. Subconjunctival draining minimally-invasive glaucoma devices such as the Xen gelatin implant and InnFocus stent have been introduced as a treatment to prevent glaucoma progressing.These implants provide a channel to allow aqueous humour from the anterior chamber of the eye to drain into the subconjunctival space on the surface of the eye thus reducing intraocular pressure (IOP) and mimicking the mechanism of the most commonly undertaken glaucoma surgery, trabeculectomy. Read More

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http://doi.wiley.com/10.1002/14651858.CD012742.pub2
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http://dx.doi.org/10.1002/14651858.CD012742.pub2DOI Listing
December 2018
7 Reads

National Study of Ocular Hospitalizations in Medicare Beneficiaries.

Am J Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois USA; Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, Illinois USA; Veterans Affairs Health Services Research and Development Service, Chicago, Illinois USA. Electronic address:

Purpose: To study the characteristics of Medicare Beneficiaries hospitalized for ophthalmic conditions DESIGN: Cross-sectional study METHODS: The 2015 National Medicare 100% Inpatient Limited Dataset was analyzed to identify all patients with either an admitting or primary diagnoses for an ophthalmic condition using ICD-9-CM codes. All other hospitalized Medicare patients served for comparison. Comorbidities were calculated using the Elixhauser Comorbidity Index. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183067
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http://dx.doi.org/10.1016/j.ajo.2018.12.003DOI Listing
December 2018
4 Reads

Management of Postoperative Ocular Hypotony after Tube Surgery by Stenting Using Two 5-0 Nylon Threads.

Korean J Ophthalmol 2018 Dec;32(6):523-524

Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3341/kjo.2018.0092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288013PMC
December 2018

Relationship between Progressive Changes in Lamina Cribrosa Depth and Deterioration of Visual Field Loss in Glaucomatous Eyes.

Korean J Ophthalmol 2018 Dec;32(6):470-477

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To investigate the relationship between the progression of visual field (VF) loss and changes in lamina cribrosa depth (LCD) as determined by spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging in patients with primary open angle glaucoma (POAG).

Methods: Data from 60 POAG patients (mean follow-up, 3.5 ± 0. Read More

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http://dx.doi.org/10.3341/kjo.2018.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288017PMC
December 2018

Glaucoma - Next Generation Therapeutics: Impossible to Possible.

Pharm Res 2018 Dec 13;36(2):25. Epub 2018 Dec 13.

Ophthalmology Research, Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, Massachusetts, 02139, USA.

The future of next generation therapeutics for glaucoma is strong. The recent approval of two novel intraocular pressure (IOP)-lowering drugs with distinct mechanisms of action is the first in over 20 years. However, these are still being administered as topical drops. Read More

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http://link.springer.com/10.1007/s11095-018-2557-4
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http://dx.doi.org/10.1007/s11095-018-2557-4DOI Listing
December 2018
4 Reads

Activation of 5-HT1A receptors promotes retinal ganglion cell function by inhibiting the cAMP-PKA pathway to modulate presynaptic GABA release in chronic glaucoma.

J Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Eye Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Serotonin receptor agonists are neuroprotective in central nervous system (CNS) injury models. However, the neuroprotective functional implications and synaptic mechanism of 8-OH-DPAT, a serotonin receptor (5-HT1A) agonist, in an adult male Wistar rat model of chronic glaucoma model remain unknown. We found that ocular hypertension decreased 5-HT1A receptor expression in rat retinas, as the number of retinal ganglion cells (RGCs) was significantly reduced in rats with induced ocular hypertension relative to that in control retinas, and 8-OH-DPAT enhanced the RGC viability. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1685-18.2018DOI Listing
December 2018

Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries.

J Immunol 2019 Jan 12;202(2):539-549. Epub 2018 Dec 12.

Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114.

Reactive microglia and infiltrating peripheral monocytes have been implicated in many neurodegenerative diseases of the retina and CNS. However, their specific contribution in retinal degeneration remains unclear. We recently showed that peripheral monocytes that infiltrate the retina after ocular injury in mice become permanently engrafted into the tissue, establishing a proinflammatory phenotype that promotes neurodegeneration. Read More

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http://dx.doi.org/10.4049/jimmunol.1800982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325007PMC
January 2019

Computed Tomography Angiography of Bilateral Intracavernous Internal Carotid Artery Aneurysms.

Neuroophthalmology 2018 Dec 26;42(6):404-405. Epub 2018 Mar 26.

Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Bilateral intracavernous internal carotid artery aneurysms are rare. They are more common in elderly females and are associated with hypertension. We present the computed tomography angiography findings of an 81-year-old female with history of hypertension who came complaining of diplopia and headache. Read More

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https://www.tandfonline.com/doi/full/10.1080/01658107.2018.1
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http://dx.doi.org/10.1080/01658107.2018.1433690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276946PMC
December 2018
2 Reads

Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound.

J Emerg Med 2018 Dec 8. Epub 2018 Dec 8.

Department of Emergency Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida.

Background: Cerebral venous thrombosis (CVT) is a rare, difficult-to-diagnose form of venous thromboembolic disease and is considered a type of stroke. Its presentation is highly variable and may be easily confused for more common and less debilitating or life-threatening diagnoses such as migraine, seizure, or idiopathic intracranial hypertension.

Case Report: A 25-year-old woman presented with a complaint of bifrontal throbbing headache and blurry vision. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.10.036DOI Listing
December 2018
1 Read

New perspectives in the use of laser diode transscleral cyclophotocoagulation. A prospective single center observational cohort study.

Rom J Morphol Embryol 2018 ;59(3):869-872

Department of Neurology, "Victor Babeş" University of Medicine and Pharmacy, "Pius Brînzeu" Emergency County Clinical Hospital, Timişoara, Romania; Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Purpose: The paper intends to present the results of using new methods of a new generation diode laser transscleral cyclophotocoagulation (TSCPC) in patients with different types of glaucoma.

Patients, Materials And Methods: There have been treated 53 eyes from 59 patients with glaucoma refractory to medical, laser or surgical treatment. We have used the newest generation of 810 nm wavelength diode laser. Read More

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January 2019

Choroidal structural analysis in eyes with diabetic retinopathy and diabetic macular edema-A novel OCT based imaging biomarker.

PLoS One 2018 11;13(12):e0207435. Epub 2018 Dec 11.

Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: To evaluate structural changes in the choroid among patients with diabetic macular edema (DME), with varying grades of diabetic retinopathy (DR), using enhance depth imaging spectral domain optical coherence tomography (EDI SD-OCT) scans.

Methods: A cross-sectional study was conducted on 82 eyes with DR and DME and 86 healthy control eyes. Eyes with DME were classified according to the severity of DR as per the international DR severity scale. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207435PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289408PMC
December 2018
3.234 Impact Factor

[Outcomes of 27G(+) transconjunctival sutureless vitrectomy for posterior segment disease].

Authors:
J P Liu Y Shao X R Li

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):918-922

Tianjin Medical University Eye Hospital, College of Optometry and Ophthalmology, Tianjin Medical University Eye Institute, Tianjin 300384, China.

To report the clinical outcomes and safety profile of 27G(+) transconjunctival sutureless vitrectomy (TSV) in eyes with posterior segment disease. Prospective, interventional case series. Eyes undergoing 27G(+) TSV for a vitreoretinal surgery indication were included from Dec 2015 to Mar 2016. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.12.009DOI Listing
December 2018

Evaluation of RETICs Glaucoma Diagnostic Calculators in Preperimetric Glaucoma.

Transl Vis Sci Technol 2018 Nov 30;7(6):13. Epub 2018 Nov 30.

Institut Catalá de Retina, Universitat Internacional de Catalunya, Barcelona, Spain.

Purpose: To evaluate two glaucoma diagnostic calculators (GDC) in a group of eyes with preperimetric glaucoma (PPG).

Methods: All eyes ( = 265) included in this study had ocular hypertension with normal visual fields (VFs) on repeated VF tests. PPG was defined as progression in the Guided Progression Analysis software from Cirrus-optical coherence tomography (GPA-OCT). Read More

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http://dx.doi.org/10.1167/tvst.7.6.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269137PMC
November 2018
3 Reads

Diagnostic and prognostic value of the optic nerve sheath diameter with respect to the intracranial pressure and neurological outcome of patients following hemicraniectomy.

BMC Neurol 2018 Dec 5;18(1):199. Epub 2018 Dec 5.

Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou City, 310009, Zhejiang Province, China.

Background: In cases showing cerebrospinal fluid (CSF) redistribution as a compensatory mechanism in acute intracranial hypertension, the optic nerve sheath diameter (ONSD) can be used to estimate intracranial pressure (ICP). However, it remains unclear whether the ONSD can be applied in patients with skull defects after a craniectomy, because the primary injury or surgical craniectomy may alter the dynamics of the CSF circulation or structure of the optical nerve sheath. This study explored the value of the ONSD in patients after a hemicraniectomy. Read More

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http://dx.doi.org/10.1186/s12883-018-1202-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280512PMC
December 2018
1 Read

Cataracts in Labrador Retriever and Jack Russell Terrier From the United Kingdom: A Two-Year Retrospective Study.

Top Companion Anim Med 2018 Dec 7;33(4):109-113. Epub 2018 Sep 7.

Department of Veterinary Medicine/Center for Investigation Vasco da Gama (DMV/CIVG), University School Vasco da Gama, 3020-210 Coimbra, Portugal; LAQV, REQUIMTE, Laboratory of Bromatology and Pharmacognosy, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. Electronic address:

Cataracts are among the most common ocular diseases, and are a leading cause of vision loss in humans and dogs. Jack Russell Terriers (JRT) and Labrador Retrievers (LR) are among the most popular canine breeds in the United Kingdom, and also among the most affected by cataracts. This study aimed to analyze the clinical features and the surgical outcome of cataracts in JRT and LR in an ophthalmologic reference Veterinary Hospital in the United Kingdom. Read More

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http://dx.doi.org/10.1053/j.tcam.2018.09.001DOI Listing
December 2018
1 Read

Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An OCT Angiography Study.

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea. Electronic address:

Objective: To investigate retinal blood flow in patients with hypertension using optical coherence tomography angiography (OCTA) and the relationship between blood flow metrics and ganglion cell-inner plexiform layer (GC-IPL) thickness.

Design: Retrospective, cross-sectional study.

Methods: A total of 201 eyes from 117 healthy subjects and 84 hypertensive patients without any ocular abnormalities were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183065
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http://dx.doi.org/10.1016/j.ajo.2018.11.016DOI Listing
November 2018
6 Reads

Ocular manifestations in acute lymphoblastic leukemia: A five-year cohort study of pediatric patients.

Leuk Res 2019 Jan 29;76:24-28. Epub 2018 Nov 29.

Department of Medicine, Federal University of Sergipe, Aracaju, Sergipe, Brazil.

Objective: To characterize ocular manifestations (OM) of pediatric patients treating for acute lymphoblastic leukemia (ALL) and to evaluate whether they are associated with well-described predictive risk factors for relapse, protocol (1999 or 2009), gender and cerebrospinal fluid infiltration.

Methods: A prospective cohort study was conducted in children and adolescents with ALL from January 2013 to December 2017. The patients underwent ophthalmologic evaluations before starting treatment (D0), on the eighth day (D8), at the 28th day (D28), and at six months (D6 months). Read More

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http://dx.doi.org/10.1016/j.leukres.2018.11.017DOI Listing
January 2019
1 Read