59,958 results match your criteria Ocular Hypertension

Agonistic autoantibodies against ß2-adrenergic receptor influence retinal microcirculation in glaucoma suspects and patients.

PLoS One 2021 7;16(5):e0249202. Epub 2021 May 7.

Department of Ophthalmology, University of Erlangen-Nürnberg, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.

Purpose: Agonistic β2-adrenergic receptor autoantibodies (β2-agAAb) have been observed in sera of patients with ocular hypertension and open-angle glaucoma (OAG). They target the β2-receptors on trabecular meshwork, ciliary body and pericytes (Junemann et al. 2018; Hohberger et al. Read More

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Laser in Glaucoma and Ocular Hypertension Trial (LIGHT) in China A Randomized Controlled Trial: Design and Baseline Characteristics.

Am J Ophthalmol 2021 May 2. Epub 2021 May 2.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, PRC. Electronic address:

Purpose: To describe the baseline characteristics of a trial to evaluate whether selective laser trabeculoplasty (SLT), as a first-line treatment, provides superior economic and health-related quality of life outcomes to medical treatment in China.

Design: LiGHT China trial is an unmasked, single-center, pragmatic, Randomized controlled trial.

Methods: 771 previously undiagnosed patients with primary open angle glaucoma (POAG, 622 patients) or ocular hypertension (OHT, 149 patients) at Zhongshan Ophthalmic Center were recruited from March 2015 to January 2019. Read More

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Primary malignant melanoma of the esophagus successfully treated with nivolumab: a case report.

J Med Case Rep 2021 May 5;15(1):237. Epub 2021 May 5.

Department of Gastroenterological Surgery, Kawasaki Saiwai Hospital, 31-27 Omiyacho, Saiwai-ku, Kawasaki city, Kanagawa, 212-0014, Japan.

Introduction: Primary malignant melanoma of the esophagus is a rare and aggressive disease that tends to have a poor response to chemotherapies. Previous studies have indicated that currently available treatment for primary malignant melanoma of the esophagus is insufficient. Here, we describe a case of recurrent primary malignant melanoma of the esophagus successfully treated with the immune checkpoint inhibitor nivolumab. Read More

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ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice.

Invest Ophthalmol Vis Sci 2021 May;62(6)

North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, United States.

Purpose: In POAG, elevated IOP remains the major risk factor in irreversible vision loss. Increased TGFβ2 expression in POAG aqueous humor and in the trabecular meshwork (TM) amplifies extracellular matrix (ECM) deposition and reduces ECM turnover in the TM, leading to a decreased aqueous humor (AH) outflow facility and increased IOP. Inhibitor of DNA binding proteins (ID1 and ID3) inhibit TGFβ2-induced fibronectin and PAI-1 production in TM cells. Read More

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Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction.

Redox Biol 2021 Apr 24;43:101988. Epub 2021 Apr 24.

Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. We assess the effects of nicotinamide (a precursor to NAD) on retinal ganglion cells (the affected neuron in glaucoma) in normal physiological conditions and across a range of glaucoma relevant insults including mitochondrial stress and axon degenerative insults. Read More

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Surgical Outcomes of Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) in Patients with Open-Angle Glaucoma - A Retrospective Case Series.

Klin Monbl Augenheilkd 2021 Apr 30;238(4):391-395. Epub 2021 Apr 30.

Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland.

Purpose: To evaluate the outcome of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with open-angle glaucoma (OAG).

Participants And Methods: A retrospective case series of patients with uncontrolled OAG treated by GATT at the cantonal Hospital Lucerne, a tertiary referral center, between October 2018 and July 2019 with a minimal 6-month follow-up period. Main outcome measures were intraocular pressure (IOP), number of antiglaucoma medications, and complications. Read More

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Retrobulbar blood flow in rat eyes during acute elevation of intraocular pressure.

Exp Eye Res 2021 Apr 28;207:108606. Epub 2021 Apr 28.

F.L. Lizzi Center for Biomedical Engineering, Riverside Research, New York, NY, USA.

Most studies of the effect of acute elevation of intraocular pressure (IOP) on ocular blood-flow have utilized optical coherence tomography (OCT) to characterize retinal and choroidal flow and vascular density. This study investigates the effect of acute IOP elevation on blood flow velocity in the retrobulbar arteries and veins supplying and draining the eye, which, unlike the retinal and choroidal vasculature, are not directly compressed as IOP is increased. By cannulation of the anterior chamber of 20 Sprague-Dawley rats, we increased IOP in 10 mmHg steps from 10 to 60 mmHg and returned to 10 mmHg. Read More

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Safety of Phakic Intraocular Collamer Lens (Visian ICL) Implantation in 95 Highly Myopic Special-Needs Children.

J Cataract Refract Surg 2021 Apr 26. Epub 2021 Apr 26.

1Departments of Ophthalmology and Visual Sciences, 2Pediatrics, and 3Neuroscience Washington University in St. Louis School of Medicine St. Louis, Missouri.

Purpose: Children with high ametropia who have difficulties with spectacle or contact lens wear benefit from gains in visual function after intraocular collamer lens (ICL) surgery. Here we assess safety by reporting rates and case specifics of peri-operative and longer-term adverse events (AE).[LINE SEPARATOR] SETTING:: St. Read More

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Med Clin North Am 2021 May 2;105(3):493-510. Epub 2021 Apr 2.

Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

Glaucoma is the leading cause of irreversible blindness worldwide. The global prevalence of glaucoma in people aged 40 to 80 years is estimated to be 3.5%. Read More

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Short-term outcomes of a modified technique for small-incision scleral-fixated intraocular lens implantation using Gore-Tex sutures.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 29. Epub 2021 Apr 29.

Department of Ophthalmology, National Taiwan University Hospital, No 7, Chung-Shan S. Rd., Taipei, 100, Taiwan.

Purpose: To report the short-term outcomes of a modified small-incision technique for implantation of scleral-fixated intraocular lenses (IOLs) using Gore-Tex sutures.

Methods: A retrospective, interventional, consecutive case series was conducted. From June 2019 to February 2020, 10 patients underwent small-incision scleral-fixated IOL implantation using Gore-Tex sutures at a tertiary referral center. Read More

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Fundus evaluation in COVID-19 positives with non-severe disease.

Indian J Ophthalmol 2021 May;69(5):1271-1274

Department of Vitreo-Retina, Regional Institute of Ophthalmology, Minto Ophthalmic Hospital, BMCRI, Bengaluru, Karnataka, India.

Purpose: The aim of this work was to study and document retinal changes in coronavirus disease-2019 (COVID-19) positive patients with nonsevere disease using a nonmydriatic handheld fundus camera.

Methods: A cross-sectional observational study was conducted on patients affected by COVID-19 who were admitted at our center. Our study included patients with no, mild, and moderate symptoms (nonsevere cases). Read More

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Development and validation of a fast ultra high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for determining carbonic anhydrase inhibitors and their metabolites in urine and hair.

Drug Test Anal 2021 Apr 27. Epub 2021 Apr 27.

Department of Excellence of Biomedical Sciences and Public Health, University "Politecnica delle Marche" of Ancona, Via Tronto 10/A, 60126, Ancona, Italy.

A new, rapid, sensitive and comprehensive ultra-high-performance liquid chromatographic-mass spectrometry (UHPLC-MS/MS) method for quantifying diuretics (acetazolamide, brinzolamide, dorzolamide and their metabolites) in human urine and hair was developed and fully validated. Twenty-five milligrams of hair, were incubated with 500 μL M3® buffer reagent at 100°C for 1 h for complete digestion. After cooling, 1 μL supernatant was injected onto chromatography system. Read More

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Twelve-month results of ab interno trabeculectomy with Kahook Dual Blade: an interventional, randomized, controlled clinical study.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 27. Epub 2021 Apr 27.

Ophthalmology Department, Instituto de Investigación Sanitaria San Carlos (IdISSC), San Carlos Clinical Hospital, Madrid, Spain.

Purpose: To evaluate the efficacy and safety profile of Kahook Dual Blade ab interno trabeculectomy combined with phacoemulsification compared to stand-alone conventional cataract surgery.

Methods: A single-center longitudinal, randomized controlled trial was conducted. Patients older than 18 years with coexisting cataract and open-angle glaucoma or ocular hypertension were invited to participate. Read More

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Space Flight-Associated Neuroocular Syndrome, Idiopathic Intracranial Hypertension, and Pseudotumor Cerebri: Phenotypic Descriptions, Pathogenesis, and Hydrodynamics.

Cureus 2021 Mar 25;13(3):e14103. Epub 2021 Mar 25.

Neurology, Flowers Medical Group, Dothan, USA.

Recent data from astronauts who have returned to Earth from a long-duration space flight have unequivocally distinguished spaceflight-associated neuro-ocular syndrome (SANS) from idiopathic intracranial hypertension (IIH) and pseudotumor cerebri (PTC). We review the semiology and pathogenesis of these three entities, noting that optic disc edema is what unites them, and this where the similarities between SANS and IIH/PTC end. We distinguish between PTC and IIH and between SANS and IIH/PTC and review the medical and surgical therapy of IIH/PTC. Read More

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NADPH oxidase-induced oxidative stress in the eyes of hypertensive rats.

Mol Vis 2021 2;27:161-178. Epub 2021 Apr 2.

Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla. CL Profesor García González, Sevilla, Spain.

Purpose: Increased reactive oxygen species (ROS) released by NADPH oxidase and inflammation are associated with arterial hypertension and eye diseases associated with high blood pressure, including glaucoma, retinopathies (e.g., age-related macular degeneration), and choroidopathies affecting ocular function; however, the mechanisms underlying these adverse outcomes remain undefined. Read More

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Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension.

Sci Rep 2021 Apr 27;11(1):9052. Epub 2021 Apr 27.

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94304, USA.

Recently, we established silicone oil-induced ocular hypertension (SOHU) mouse model with significant glaucomatous neurodegeneration. Here we characterize two additional variations of this model that simulate two distinct glaucoma types. The first is a chronic model produced by high frequency (HF) pupillary dilation after SO-induced pupillary block, which shows sustained moderate IOP elevation and corresponding slow, mild glaucomatous neurodegeneration. Read More

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MRI-based quantification of ophthalmic changes in healthy volunteers during acute 15° head-down tilt as an analogue to microgravity.

J R Soc Interface 2021 04 28;18(177):20200920. Epub 2021 Apr 28.

Alcyone Therapeutics Inc., Lowell, MA 01852, USA.

Spaceflight is known to cause ophthalmic changes in a condition known as spaceflight-associated neuro-ocular syndrome (SANS). It is hypothesized that SANS is caused by cephalad fluid shifts and potentially mild elevation of intracranial pressure (ICP) in microgravity. Head-down tilt (HDT) studies are a ground-based spaceflight analogue to create cephalad fluid shifts. Read More

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A longitudinal comparison in cynomolgus macaques of the effect of brimonidine on optic nerve neuropathy using diffusion tensor imaging magnetic resonance imaging and spectral domain optical coherence tomography.

Heliyon 2021 Apr 6;7(4):e06701. Epub 2021 Apr 6.

Pharmacology, Hamamatsu Pharma Research, Inc., 1-3-7, Shinmiyakoda, Kita-ku, Hamamatsu, Shizuoka, 431-2103, Japan.

Early detection of optic neuropathy is crucial for initiating treatment that could delay or prevent visual field loss. Preclinical studies have advanced a number of potential neuroprotective strategies to prevent retinal ganglion cell (RGC) degeneration, but none have successfully completed clinical trials. One issue related to the lack of preclinical to clinical translation is the lack of preclinical morphometric assessments that could be used to track neuroprotection, as well as neurodegeneration, over time within the same animal. Read More

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Preserved Versus Preservative-Free Latanoprost for the Treatment of Glaucoma and Ocular Hypertension: A Post Hoc Pooled Analysis.

Adv Ther 2021 Apr 23. Epub 2021 Apr 23.

Quinze-Vingts National Ophthalmology Hospital, Paris, France.

Introduction: To compare the tolerability and efficacy of a preservative-containing latanoprost (PCL) to a preservative-free formulation of latanoprost (PFL) in patients with open-angle glaucoma or ocular hypertension.

Methods: A pooled analysis was performed of data from five published studies. The primary outcome was tolerability as evaluated by the severity of hyperemia. Read More

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Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: UK and Ireland Results from the VISIONARY Study.

Adv Ther 2021 Apr 22. Epub 2021 Apr 22.

Royal Victoria Infirmary, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Introduction: Reducing intraocular pressure (IOP), the only modifiable risk factor for open-angle glaucoma (OAG), is important for the preservation of vision and slowing of disease progression. Preservative-free tafluprost (0.0015%)/timolol (0. Read More

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A miRNA stabilizing polydopamine nano-platform for intraocular delivery of miR-21-5p in glaucoma therapy.

J Mater Chem B 2021 Apr 30;9(15):3335-3345. Epub 2021 Mar 30.

Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.

The elevation of intraocular pressure (IOP) is an important risk factor in the development of primary open angle glaucoma (POAG), which is the main cause of irreversible vision loss. miRNAs are promising new anti-glaucoma therapeutic agents. However, the low stability and cellular transfection of miRNA in vivo hinder its further application. Read More

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[Examination of patients with glaucoma during the COVID-19 pandemic].

Vestn Oftalmol 2021 ;137(2):75-83

State Scientific Center of the Russian Federation - A.I. Burnazyan Federal Medical and Biophysical Center of FMBA, Moscow, Russia.

Purpose: To evaluate the efficacy of the optimal examination technique for patients with glaucoma during the COVID-19 pandemic that includes one of the safest methods of tonometry [transpalpebral tonometry (TPT), contour dynamic tonometry (CDT) and Icare rebound tonometry (RBT)] in combination with spectral domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA).

Material And Methods: The study included 65 patients with primary open-angle glaucoma (POAG) who sought medical aid at the Ophthalmological Center of FMBA during the COVID-19 pandemic; they were examined using three tonometry methods: RBT, TPT and CDT. All patients underwent central corneal thickness measurement, perimetry, OCT and OCTA with assessment of vessel density (VD) of the superficial plexus in the macula (whole image macula) and peripapillary retina (PPR). Read More

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Prevalence of Incidentally Detected Signs of Intracranial Hypertension on Magnetic Resonance Imaging and Their Association With Papilledema.

JAMA Neurol 2021 Apr 19. Epub 2021 Apr 19.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.

Importance: Magnetic resonance imaging (MRI) signs of intracranial hypertension (IH) are traditionally associated with idiopathic intracranial hypertension (IIH), but these signs are also detected among individuals with primary headaches and among asymptomatic individuals without papilledema.

Objective: To examine the prevalence of MRI signs of IH among consecutive outpatients undergoing brain MRI for any clinical indication and to explore their association with papilledema.

Design, Setting, And Participants: This prospective cross-sectional study of outpatients undergoing brain MRI at 1 outpatient imaging facility was conducted between August 1, 2019, and March 31, 2020, with ocular fundus photographs taken concurrently. Read More

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Detecting Progression in Patients with Different Clinical Presentations of Primary Open-angle Glaucoma.

J Glaucoma 2021 Apr 12. Epub 2021 Apr 12.

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, AL 35233, USA Computational Optometry, Atarfe, Spain.

Prcis: Glaucoma progression was more frequently identified by assessing retinal fiber layer thickness than by monitoring visual field loss for different baseline classifications in primary open-angle glaucoma.

Purpose: To compare the detection of glaucoma progression by retinal nerve fiber layer thickness (RNFLT) and visual field (VF) assessments for different baseline classifications of primary open-angle glaucoma (POAG).

Methods: This study included 194 eyes from 194 patients with a minimum of 9 follow-up visits selected from the Diagnostic Innovation in Glaucoma Study and the African Descent and Glaucoma Evaluation Study. Read More

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Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension.

Theranostics 2021 13;11(11):5447-5463. Epub 2021 Mar 13.

Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan.

Y-27632 is a potent ophthalmic drug for the treatment of ocular hypertension, a globally prevalent eye disease. However, the sustained delivery of Y-27632 by a therapeutic carrier to lesion sites located in the inner segments of the eye for effectively treating the ocular disorder still remains challenging. To realize the goal, a strategy based on solvothermal-assisted deposition/infiltration in combination with surface modification is utilized to synthesize hollow mesoporous ceria nanoparticles (HMCNs) with tailorable shell thicknesses and drug release profiles. Read More

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Assessment of Cumulative Incidence and Severity of Primary Open-Angle Glaucoma Among Participants in the Ocular Hypertension Treatment Study After 20 Years of Follow-up.

JAMA Ophthalmol 2021 Apr 15. Epub 2021 Apr 15.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine in St Louis, St Louis, Missouri.

Importance: Ocular hypertension is an important risk factor for the development of primary open-angle glaucoma (POAG). Data from long-term follow-up can be used to inform the management of patients with ocular hypertension.

Objective: To determine the cumulative incidence and severity of POAG after 20 years of follow-up among participants in the Ocular Hypertension Treatment Study. Read More

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Visual and Ocular Conditions among a Homeless Adult Population of Boston.

Optom Vis Sci 2021 Apr;98(4):362-366

Department of Primary Care, New England College of Optometry, Boston, Massachusetts.

Significance: The eye care needs of the homeless population in the United States are not well known. This study elucidates those needs for health care for the homeless programs and eye care practitioners. This information could result in an increase in the provision of necessary eye care services. Read More

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Molecular Insights into Myocilin and Its Glaucoma-Causing Misfolded Olfactomedin Domain Variants.

Acc Chem Res 2021 May 13;54(9):2205-2215. Epub 2021 Apr 13.

School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Dr. NW, Atlanta, Georgia 30332-0400, United States.

ConspectusNumerous human disorders arise due to the inability of a particular protein to adopt its correct three-dimensional structure in the context of the cell, leading to aggregation. A new addition to the list of such protein conformational disorders is the inherited subtype of glaucoma. Different and rare coding mutations in myocilin, found in families throughout the world, are causal for early onset ocular hypertension, a key glaucoma risk factor. Read More

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Role of the renin-angiotensin system in the development of cataract formation in angiotensin-II-induced experimental rats.

J Biochem Mol Toxicol 2021 Apr 13:e22789. Epub 2021 Apr 13.

Department of Pharmacology, Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India.

Previously, we established several facts regarding hypertension-associated cataractogenesis. As a follow-on study, we evaluated the role of the renin-angiotensin system (RAS) in angiotensin-II (Ang-II)-induced cataract formation in experimental hypertensive rats. Sprague-Dawley male albino rats (150-180 g) were used for the present experiment. Read More

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Evaluation of the direct effects on retinal and choroidal microvascularity of systemic scleroderma.

Microvasc Res 2021 Apr 9;136:104166. Epub 2021 Apr 9.

University of Health Sciences, Antalya Training and Research Hospital, Department of Ophthalmology, Antalya, Turkey.

Objective: Ocular involvement in systemic sclerosis (SSc) has been documented; however it cannot be distinguished from secondary changes due to concomitant hypertension.Therefore, the aim of this prospective cross-sectional study was to demonstrate the direct effects of Ssc on retinal and choroidal microvasculature in patients without hypertension.

Methods: 47 SSc patients and 44 age- and sex-matched healthy control subjects were enrolled in this study. Read More

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