55,002 results match your criteria Ocular Hypertension


Bilateral acute iris depigmentation and bilateral acute iris transillumination syndrome.

Arch Soc Esp Oftalmol 2019 Mar 13. Epub 2019 Mar 13.

Servicio de Oftalmología, Sección de Retina Médica, Hospital Universitario Virgen del Rocío, Sevilla, España.

The case is presented of a 32 year-old male who arrived with acute bilateral symptoms with blurred vision, red eye, severe photophobia and severe ocular pain after suffering from a flu-like syndrome. The patient presented with a clinical picture of bilateral involvement characterised by pupils in mid-mydriasis, scarcely reactive to light, iris transillumination, diffuse depigmentation of the iridian stroma, pigment dispersion in the anterior chamber, and ocular hypertension. After the eye examination an inflammatory syndrome and pigmentary glaucoma were ruled out. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.11.002DOI Listing

Correction to: Safety and Efficacy of Ripasudil in Japanese Patients with Glaucoma or Ocular Hypertension: 3-month Interim Analysis of ROCK-J, a Post-Marketing Surveillance Study.

Adv Ther 2019 Mar 13. Epub 2019 Mar 13.

Post Marketing Surveillance Department, Kowa Company, Ltd., Tokyo, Japan.

In the original publication values in the results section are incorrect. Errors were also identified in Fig. 5. Read More

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http://dx.doi.org/10.1007/s12325-019-0892-4DOI Listing

Once-Daily Netarsudil vs Twice-Daily Timolol in Patients with Elevated Intraocular Pressure, the Randomized Phase 3 ROCKET-4 Study.

Am J Ophthalmol 2019 Mar 9. Epub 2019 Mar 9.

Aerie Pharmaceuticals, Inc., Irvine, California; Bedminster, New Jersey; and Durham, North Carolina, USA.

Purpose: To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once-daily (QD) and timolol twice-daily (BID).

Design: Double-masked, randomized, phase 3, non-inferiority study.

Methods: Patients with open-angle glaucoma or ocular hypertension (unmedicated baseline IOP >20 to <30 mmHg at 8:00 AM) were randomized to netarsudil ophthalmic solution 0. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.002DOI Listing

Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.

Lancet 2019 Mar 8. Epub 2019 Mar 8.

The Research Department of Primary Care and Population Health, University College London, London, UK.

Background: Primary open angle glaucoma and ocular hypertension are habitually treated with eye drops that lower intraocular pressure. Selective laser trabeculoplasty is a safe alternative but is rarely used as first-line treatment. We compared the two. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32213-XDOI Listing
March 2019
2 Reads

Improved immunohistochemical detection of phosphorylated mitogen-activated protein kinases in the injured rat optic nerve head.

Histochem Cell Biol 2019 Mar 11. Epub 2019 Mar 11.

Ophthalmic Research Laboratories, Central Adelaide Local Health Network, Level 7 Adelaide Health & Medical Sciences Building, University of Adelaide, Adelaide, SA, Australia.

The activity of mitogen-activated protein kinases (MAPKs) is largely controlled by addition or removal of phosphate groups, which are carried out by kinase or phosphatase enzymes, respectively. Determining the phosphorylation status of MAPK isoenzymes, therefore, aids elucidation of the physiological and pathological roles of this enzyme. In practical terms, however, end-point procurement of appropriate experimental tissues produces conditions where MAPK phosphorylation status can rapidly alter, thus giving rise to aberrant data. Read More

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http://dx.doi.org/10.1007/s00418-019-01771-xDOI Listing

GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure.

J Ocul Pharmacol Ther 2019 Mar 11. Epub 2019 Mar 11.

1 Department of Ophthalmology, Tufts University School of Medicine at New England Eye Center, Tufts Medical Center, Boston, Massachusetts.

Purpose: GPR158 is a newly characterized family C G-protein-coupled receptor, previously identified in functional screens linked with biological stress, including one for susceptibility to ocular hypertension/glaucoma induced by glucocorticoid stress hormones. In this study, we investigated GPR158 function in the visual system.

Methods: Gene expression and protein immunolocalization analyses were performed in mouse and human brain and eye to identify tissues where GPR158 might function. Read More

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http://dx.doi.org/10.1089/jop.2018.0135DOI Listing

Long-term effectiveness and safety of trabecular microbypass stent implantation with cataract surgery in patients with glaucoma or ocular hypertension: Five-year outcomes.

J Cataract Refract Surg 2019 Mar;45(3):312-320

Glaukos Corp., San Clemente, California, USA.

Purpose: To assess 5-year outcomes after implantation of 1 trabecular microbypass stent during cataract surgery in eyes with open-angle glaucoma (OAG) or ocular hypertension.

Setting: Private ophthalmology clinic (AaM Augenklinik am Marienplatz, Munich, Germany).

Design: Prospective nonrandomized consecutive case series. Read More

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http://dx.doi.org/10.1016/j.jcrs.2018.10.029DOI Listing

Acute emotional stress as a trigger for intraocular pressure elevation in Glaucoma.

BMC Ophthalmol 2019 Mar 8;19(1):69. Epub 2019 Mar 8.

Glaucoma Research Center, Montchoisi Clinic, Swiss Visio Network, Lausanne, Switzerland.

Background: Stress-induced activation of the sympathetic nervous system leads to a cascade of metabolic reactions. Emotional stress is a more specific form of stress in which the stressor is a psychological response to a situation subjectively perceived as traumatic. Stress hormones can have a wide range of effects on the body, however, it is still unclear if and how it can affect ophthalmic physiology. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-019-1075-4DOI Listing
March 2019
2 Reads

Ocular manifestations of pulmonary hypertension.

Surv Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Department and Clinic of Ophthalmology, Wroclaw Medical University, Poland, ul. Borowska 213, PL-50-556 Wrocław, Poland.

Pulmonary hypertension (PH), if left untreated, may result in increasing cardiac back pressures and lead to right heart failure and death. An increase in venous pressure in pulmonary hypertension influences other organs. The ocular complications occur as a result of elevated venous pressure in the superior vena cava and in the ophthalmic veins that cause dilation of the ocular veins, resulting in congestion of the choroid and leading to complications such as ciliary detachment, central retinal vein occlusion, acute serous retinal detachment, macular edema, retinal neovascularization, choroidal effusions, chemosis, angle-closure glaucoma, transient myopia, and proptosis. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.02.009DOI Listing
March 2019
1 Read

Pterygium Prevalence and Its Associations in a Russian Population: The Ural Eye and Medical Study.

Am J Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: To assess the prevalence of pterygia and its associations in a population of Russia.

Design: Population-based cross-sectional study METHODS: The Ural Eye and Medical Study was performed in a rural and urban area in Ufa/Bashkortostan 1300 km East of Moscow. Out of 7328 eligible individuals aged 40+ years, 5,899 (80. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.031DOI Listing
March 2019
2 Reads

Intraocular Pressure and Its Associations in a Russian population: The Ural Eye and Medical Study.

Am J Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: To assess the normal distribution of intraocular pressure (IOP) and its associations with ocular, medical, and socioeconomic factors in a Russian population.

Design: Population-based cross-sectional study METHODS: The Ural Eye and Medical Study conducted in a rural and urban area in Ufa/Bashkortostan included 5,899 (80.5%) participants out of 7328 eligible individuals aged 40+ years. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.030DOI Listing
March 2019
1 Read

Ophthalmologic manifestations in Taiwanese patients with mucopolysaccharidoses.

Mol Genet Genomic Med 2019 Mar 8:e00617. Epub 2019 Mar 8.

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.

Background: Mucopolysaccharidoses (MPSs) are a group of rare lysosomal storage disorders characterized by the accumulation of glycosaminoglycans in various tissues and organs. Ocular problems that affect the cornea, trabecular meshwork, sclera, retina, and optic nerve are very common in these patients. However, there was limited literature focusing on comprehensive ocular findings in different types of MPS. Read More

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http://dx.doi.org/10.1002/mgg3.617DOI Listing
March 2019
1 Read

Evaluation of offset of conjunctival hyperemia induced by a Rho-kinase inhibitor; 0.4% Ripasudil ophthalmic solution clinical trial.

Sci Rep 2019 Mar 6;9(1):3755. Epub 2019 Mar 6.

Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Nankoku City, Kochi, Japan.

Glaucoma leads to irreversible blindness. Numerous anti-glaucoma eye drops have been developed. Unfortunately, many patients with glaucoma still suffer from progressive visual disorders. Read More

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http://dx.doi.org/10.1038/s41598-019-40255-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403378PMC
March 2019
1 Read

Effect of ripasudil on diabetic macular edema.

Sci Rep 2019 Mar 6;9(1):3703. Epub 2019 Mar 6.

Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.

The current study aimed to address whether ripasudil, a Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor developed to treat glaucoma and ocular hypertension (OH), improves diabetic macular edema (DME) since it is known that ROCK upregulates vascular endothelial growth factor. We retrospectively investigated the foveal thickness (FT) measured by spectral-domain optical coherence tomography, visual acuity (VA), and intraocular pressure (IOP) in 12 eyes with DME that received ripasudil treatment for primary open-angle glaucoma or OH and compared them with 14 eyes that received no treatment. One month after ripasudil therapy, the mean FT decreased significantly from 439 ± 72 µm to 395 ± 62 µm (P = 0. Read More

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http://dx.doi.org/10.1038/s41598-019-40194-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403390PMC

Bilateral decompression retinopathy after deep sclerectomy with mitomycin C in a child with tubulointerstitial nephritis and uveitis syndrome.

Eur J Ophthalmol 2019 Mar 6:1120672119832177. Epub 2019 Mar 6.

Department of Ophthalmology, Ramón y Cajal Hospital, Ramón y Cajal Institute of Health Research (IRYCIS), Madrid, Spain.

Introduction:: To report the first case of bilateral ocular decompression retinopathy after uneventful non-perforating deep sclerectomy with mitomycin C in a child with tubulointerstitial nephritis and uveitis syndrome.

Case Description:: An 8-year-old girl affected by tubulointerstitial nephritis and uveitis syndrome developed ocular hypertension (45 mmHg in the right eye and 42 mmHg in the left eye) associated with recurrent episodes of uveitis and chronic use of steroids despite maximum hypotensive medical treatment. Bilateral non-perforating deep sclerectomy with mitomycin C (0. Read More

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http://journals.sagepub.com/doi/10.1177/1120672119832177
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http://dx.doi.org/10.1177/1120672119832177DOI Listing
March 2019
3 Reads

Phase 2, Randomized, Dose-finding Studies of Omidenepag Isopropyl, a Selective EP2 Agonist, in Patients With Primary Open-angle Glaucoma or Ocular Hypertension.

J Glaucoma 2019 Mar 6. Epub 2019 Mar 6.

Santen Inc., Emeryville, CA, USA.

PRéCIS:: Three randomized, multicenter studies demonstrated the stable intraocular pressure-lowering effects and tolerability of omidenepag isopropyl in patients with primary open-angle glaucoma and ocular hypertension; 0.002% was identified as the optimal dose for further investigation.

Purpose: To assess the safety and efficacy of omidenepag isopropyl, a selective EP2 agonist, and to determine the optimal dose for further investigation. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001221DOI Listing
March 2019
1 Read

Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog.

BMC Vet Res 2019 Mar 4;15(1):75. Epub 2019 Mar 4.

Department of Small Animal Clinical Sciences, Veterinary Medical Center, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, East Lansing, MI, 48824, USA.

Background: Open angle glaucoma is the only type of primary glaucoma reported in Beagles. This case report describes a primary angle-closure glaucoma in a Beagle and its diagnostic and prognostic relevance.

Case Presentation: A 12-year-old, neutered male Beagle presented to the Michigan State University (MSU) Comparative Ophthalmology Service for evaluation of suspected visual impairment. Read More

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http://dx.doi.org/10.1186/s12917-019-1812-1DOI Listing
March 2019
1 Read

Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center

Turk J Ophthalmol 2019 Feb;49(1):10-14

Ulucanlar Eye Training and Research Hospital, Ophthalmology Clinic, Ankara, Turkey

Objectives: To investigate the demographic, etiologic, and clinical features of HLA-B27-associated uveitis.

Materials And Methods: The clinical records of 91 patients diagnosed with HLA-B27-associated uveitis at the Ulucanlar Eye Training and Research Hospital between the years of 2005 and 2016 were reviewed. Each patient’s presenting complaints, best-corrected visual acuities in first and last visits, biomicroscopic and fundoscopic examination findings, frequency and seasonal distribution of attacks, and demographic data such as age and sex were noted. Read More

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http://dx.doi.org/10.4274/tjo.galenos.2018.53896DOI Listing
February 2019
2 Reads

Minimally Invasive Surgery-Based Multidisciplinary Clinical Management of Reninoma: A Single-Center Study.

Med Sci Monit 2019 Mar 1;25:1600-1610. Epub 2019 Mar 1.

Department of Urology, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army (PLA) General Hospital/Chinese PLA Medical Academy, Beijing, China (mainland).

BACKGROUND This article presents our experience in managing a rare kidney tumor - reninoma - by analyzing a relatively large series of cases from a single center. MATERIAL AND METHODS Nine cases of reninoma were reviewed. Clinical manifestations, imaging examinations, laboratory examinations, perioperative data, and pathological findings were summarized. Read More

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https://www.medscimonit.com/abstract/index/idArt/913826
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http://dx.doi.org/10.12659/MSM.913826DOI Listing
March 2019
3 Reads

Ocular Manifestations in Hemodialysis Patients: Importance of Ophthalmic Examination in Prevention of Ocular Sequels.

Int J Prev Med 2019 12;10:20. Epub 2019 Feb 12.

Department of Ophthalmology, Isfahan Eye Research Center, Isfahan, Iran.

Background: Hemodialysis (HD)-associated ocular abnormalities are one of the causes of morbidity among people undergoing HD. This study evaluates the frequency of ocular abnormalities in end-stage renal disease (ESRD) patients undergoing HD and their potential link to HD and demographic parameters.

Methods: This cross-sectional study examined 242 eyes of 121 patients with ESRD undergoing regular HD after excluding the ineligible subjects. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_464_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390423PMC
February 2019
1 Read

Partial thickness cornea tissue from small incision lenticule extraction: A novel patch graft in glaucoma drainage implant surgery.

Medicine (Baltimore) 2019 Mar;98(9):e14500

Xiamen University Affiliated Xiamen Eye Center, Xiamen, China.

Objective: The aim of the present study was to observe the feasibility and effect of cornea slice acquired from femtosecond laser surgery, small incision lenticule extraction (SMILE) as patch graft for the prevention of drainage tube exposure and to compare with the sclera.

Methods: The research is a prospective comparative randomized study. Patients who received Ahmed glaucoma valve implantation surgery from August 2015 to January 2017 at the Xiamen Eye Center were randomly divided into 2 groups. Read More

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http://dx.doi.org/10.1097/MD.0000000000014500DOI Listing
March 2019
5.723 Impact Factor

Aminobisphosphonate-associated orbital and ocular inflammatory disease.

Acta Ophthalmol 2019 Feb 28. Epub 2019 Feb 28.

Division of Ophthalmology, Tel-Aviv Sourasky Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Purpose: Aminobisphosphonates may cause orbital/ocular inflammation. Awareness of the clinical presentation and disease course is crucial. The purpose of this study was to analyse demographics, clinical presentation, disease course and treatment of aminobisphosphonate-associated orbital/ocular inflammation in a large series of patients. Read More

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http://dx.doi.org/10.1111/aos.14063DOI Listing
February 2019
1 Read

Role of Histamine H₃ Receptor Antagonists on Intraocular Pressure Reduction in Rabbit Models of Transient Ocular Hypertension and Glaucoma.

Int J Mol Sci 2019 Feb 24;20(4). Epub 2019 Feb 24.

Department of Neuroscience, Psychiatry, Drug Area and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, 50130 Florence, Italy.

Intraocular pressure (IOP) has a tendency to fluctuate throughout the day, reaching its peak in the early morning in healthy subjects or glaucoma patients. Likewise, histamine tone also fluctuates over time, being lower at nighttime. Numerous studies have demonstrated a correlation between short-term IOP fluctuation and glaucoma progression; however, it has not yet been determined whether histamine plays a role in IOP fluctuations. Read More

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http://dx.doi.org/10.3390/ijms20040981DOI Listing
February 2019

Spontaneous and transient hyperglycemia before sleep in a patient with glaucomatous blindness and diabetes: A case reprt.

Medicine (Baltimore) 2019 Feb;98(8):e14590

Department of Endocrinology, Affiliated Cixi Hospital,Wenzhou Medical University, Cixi.

Rationale: The peak of blood glucose was during 9 PM to 3 AM. There is a stable, spontaneous and short-term abnormal increase of blood glucose. The pathophysiological mechanism is unknown. Read More

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http://dx.doi.org/10.1097/MD.0000000000014590DOI Listing
February 2019
1 Read
5.723 Impact Factor

Alendronate induced chorioretinitis: The importance of meticulous assessments.

Am J Ophthalmol Case Rep 2019 Jun 9;14:21-25. Epub 2019 Jan 9.

Byers Eye Institute, Stanford University, Palo Alto, CA, USA.

Purpose: To report a case of presumed bilateral chorioretinitis secondary to alendronate therapy.

Observations: A 71-year-old female presented to the clinic in July 2017 with six months history of difficulty in reading along with floaters in both eyes which were more severe in the right eye. Past medical and surgical history revealed a history of hypertension, gout, hyperthyroidism, osteoporosis, and humerus fracture. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374782PMC

Vagal Nerve Stimulation Attenuates Ischemia-Reperfusion Induced Retina Dysfunction in Acute Ocular Hypertension.

Front Neurosci 2019 11;13:87. Epub 2019 Feb 11.

Eye Center, Renmin Hospital of Wuhan University, Wuhan, China.

The present study aimed to investigate whether cervical vagal nerve stimulation (VNS) could prevent retinal ganglion cell (RGC) loss and retinal dysfunction after ischemia/reperfusion (I/R) injury. First, rats were randomly divided into sham group ( = 4) and VNS group ( = 12). Activation of the nodose ganglia (NOG), nucleus of the solitary tract (NTS), superior salivatory nucleus (SSN), and pterygopalatine ganglion (PPG) neural circuit were evaluated by c-fos expression at 0 h after sham VNS and at 0 h ( = 4), 6 h ( = 4), 72 h ( = 4) after VNS. Read More

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http://dx.doi.org/10.3389/fnins.2019.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378858PMC
February 2019
2 Reads

Patient attitudes toward novel glaucoma drug delivery approaches.

Digit J Ophthalmol 2018 30;24(2):16-23. Epub 2018 Sep 30.

Massachusetts Eye and Ear, Boston, Massachusetts.

Purpose: Understanding patients' attitudes toward novel therapeutic options can help guide providers in personalizing treatment regimens for glaucoma patients. This study aimed to determine factors associated with acceptance of new drug delivery options among glaucoma patients.

Methods: A total of 199 patient volunteers participated in an interviewer-administered survey from June to August 2016 at the Glaucoma Service of Massachusetts Eye and Ear. Read More

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http://dx.doi.org/10.5693/djo.01.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380257PMC
March 2019
1 Read

Self-inflicted injection of tattoo ink in the anterior chamber: a failed attempt to change the color of the eyes.

Digit J Ophthalmol 2018 30;24(3):10-12. Epub 2018 Jun 30.

Universidad Pontificia Bolivariana, Medellin, Colombia.

We report the case of a 29-year-old man, a tattoo artist by profession, with a history of schizophrenia, who was admitted to our hospital after injecting tattoo pigments in the anterior chamber of both eyes using a dermograph. The patient was diagnosed with penetrating ocular injury with secondary glaucoma, endotheliitis, and uveitis. Anterior chamber washout was performed immediately. Read More

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http://dx.doi.org/10.5693/djo.02.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380255PMC
March 2019
2 Reads

The effect of inhaled steroids on the intraocular pressure.

Digit J Ophthalmol 2018 12;24(3):6-9. Epub 2018 May 12.

St John's Medical College, Bengaluru, Karnataka, India.

Background: Steroids are known to play a role in the pathogenesis of glaucoma, but little is known about the effect of inhaled corticosteroids (ICS). The purpose of this study was to investigate whether there is a clinically significant association between inhalational steroids and intraocular pressure (IOP).

Methods: This was a cross-sectional, case-control study performed at St John's Medical College, Bengaluru, India, from October 2013 to July 2015 of 200 patients using 800 mcg of budesonide or its equivalent dose of ICS and 200 healthy controls not using any form of steroids. Read More

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http://dx.doi.org/10.5693/djo.01.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380256PMC

Long-term outcomes after intravitreal dexamethasone treatment in steroid responders.

Acta Diabetol 2019 Feb 24. Epub 2019 Feb 24.

LV Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills, Hyderabad, 500 034, India.

Aims: Intravitreal steroid implants have emerged as an adjunctive therapy in diabetic macular edema (DME) in patients refractory to anti-vascular endothelial growth factor agents. However, the use of these agents in patients with a prior history of steroid-induced ocular hypertension is limited. The present study aimed to analyze long-term intraocular pressure (IOP) response to the dexamethasone implant in patients with DME and a history of steroid-induced increase in IOP. Read More

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http://dx.doi.org/10.1007/s00592-019-01299-5DOI Listing
February 2019
1 Read

The Heritability of Pigment Dispersion Syndrome and Pigmentary Glaucoma.

Am J Ophthalmol 2019 Feb 20. Epub 2019 Feb 20.

Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA. Electronic address:

Purpose: Pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) are presumed to be inherited in an autosomal dominant manner. Herein, we examine relatives of patients with PDS and PG in order to determine the heritability of this disease.

Design: Prospective, cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.017DOI Listing
February 2019
1 Read

Chorioretinal folds: a proposed diagnostic algorithm.

Int Ophthalmol 2019 Feb 20. Epub 2019 Feb 20.

Clinica Oculistica, DiNOGMI, Università degli Studi di Genova, Viale Benedetto XV 5, 16132, Genoa, Italy.

Purpose: To create a diagnostic algorithm for the management of chorioretinal folds.

Methods: We reviewed the existing literature about chorioretinal folds focusing our attention on three specific conditions and created a diagnostic algorithm in order to otpimize the choice and the number of investigations.

Results: Chorioretinal folds are visible striations of the fundus usually arranged in parallel lines and disposed horizontally. Read More

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http://dx.doi.org/10.1007/s10792-019-01083-yDOI Listing
February 2019

Effect of systemic antihypertensives on change in intraocular pressure after initiating topical prostaglandins for primary open-angle glaucoma.

Clin Ophthalmol 2019 23;13:207-213. Epub 2019 Jan 23.

Medical Center Ophthalmology Associates, San Antonio, TX, USA,

Purpose: There is a limited understanding of factors that influence the efficacy of topical glaucoma medication. Our study is a long-term, case-control analysis of how systemic antihypertensive (anti-HTN) medications influence the change in IOP after initiating prostaglandin (PG) drop therapy.

Materials And Methods: A retrospective chart review of 3,781 patients was performed on patients with a diagnosis of glaucoma suspect that progressed to primary open-angle glaucoma (POAG) by ICD-9 codes over a 10-year period. Read More

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http://dx.doi.org/10.2147/OPTH.S192010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350645PMC
January 2019
2 Reads

Effect of immediate postoperative intracameral tissue plasminogen activator (tPA) on anterior chamber fibrin formation in dogs undergoing phacoemulsification.

Vet Ophthalmol 2019 Feb 18. Epub 2019 Feb 18.

Animal Eye Institute, Norwood, Ohio.

Objective: To evaluate the postoperative effect of intracameral tPA (alteplase; Activase®, Genentech, San Francisco, CA), administered at immediate conclusion of phacoemulsification, on anterior chamber fibrin formation in dogs.

Procedures: Forty-one dogs (82 eyes) undergoing bilateral phacoemulsification received 25 μg/0.1 mL intracameral tPA in one eye and 0. Read More

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http://dx.doi.org/10.1111/vop.12616DOI Listing
February 2019
2 Reads

Longitudinal Study of Peripapillary Thinning in Sickle Cell Hemoglobinopathies.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL. Electronic address:

Purpose: To determine the rate of retinal nerve fiber layer (RNFL) thinning in patients with sickle cell hemoglobinopathies. Design; Prospective cohort study METHODS: Sixty-seven patients averaging 35.8±11. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.006DOI Listing
February 2019
2 Reads

Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study.

BMC Ophthalmol 2019 Feb 15;19(1):52. Epub 2019 Feb 15.

Glaucoma Service, Department of Ophthalmology, Federal University of São Paulo, Rua Botucatu, 821, Vila Clementino, São Paulo, 04021-001, Brazil.

Background: To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters.

Methods: We prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (SITA - Standard 24-2; Carl Zeiss Meditec, Dublin, CA) and EDI OCT imaging (Spectralis; Heidelberg Engineering Co. Read More

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http://dx.doi.org/10.1186/s12886-019-1054-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377769PMC
February 2019
3 Reads

Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects.

J Ophthalmol 2019 15;2019:7419470. Epub 2019 Jan 15.

Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.

Purpose: To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA).

Methods: A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. Read More

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http://dx.doi.org/10.1155/2019/7419470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350555PMC
January 2019
4 Reads

Mucoadhesive olaminosomes: A novel prolonged release nanocarrier of agomelatine for the treatment of ocular hypertension.

Int J Pharm 2019 Feb 11;560:235-245. Epub 2019 Feb 11.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address:

Mucoadhesive olaminosomes are novel nanocarriers designed to control agomelatine release and enhance its bioavailability. Olaminosomes were prepared using oleic acid, oleylamine and sorbitan monooleate adopting thin film hydration technique. Chitosan HCl was added to impart the mucoadhesive properties to the olaminosomes. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.070DOI Listing
February 2019
1 Read

The genetic influence on corticosteroid-induced ocular hypertension: A field positioned for discovery.

Am J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114. Electronic address:

Purpose: To provide evidence that corticosteroid-induced ocular hypertension has a genetic component.

Design: Evidence-based Perspective.

Methods: We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.001DOI Listing
February 2019
1 Read

Hypertensive ocular disease in cats: A guide to fundic lesions to facilitate early diagnosis.

Authors:
Jenny Carter

J Feline Med Surg 2019 Jan;21(1):35-45

Auckland, New Zealand.

Practical Relevance:: Systemic hypertension is common in older cats and can result in damage to organs with a rich arteriolar supply such as the eyes, kidneys, myocardium and brain. Hypertensive disease in these organs is known as target organ damage (TOD). Disease in the eye resulting from hypertension is the most easily identifiable form of TOD and can often be the reason the cat is presented to the veterinarian. Read More

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http://journals.sagepub.com/doi/10.1177/1098612X18818668
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http://dx.doi.org/10.1177/1098612X18818668DOI Listing
January 2019
5 Reads

Migraine and increased risk of developing open angle glaucoma: a population-based cohort study.

BMC Ophthalmol 2019 Feb 13;19(1):50. Epub 2019 Feb 13.

Department of Ophthalmology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.

Background: Migraine is linked to endothelial dysfunction and is considered to be a systemic vasculopathy. Interestingly, systemic vascular diseases also occur in glaucoma patients and are considered to be vascular risk factors. Whether migraine is simply a concomitant condition in glaucoma patients or a risk factor per se for glaucoma remains unknown. Read More

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http://dx.doi.org/10.1186/s12886-019-1062-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375150PMC
February 2019
1 Read

Ciliochoroidal detachment after Ahmed glaucoma valve implantation: a retrospective study.

BMC Ophthalmol 2019 Feb 6;19(1):46. Epub 2019 Feb 6.

Affiliated Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, China.

Background: To investigate the occurrence of ciliochoroidal detachment (CCD), its risk factors and its impact on the success rate after Ahmed glaucoma valve (AGV) implantation.

Methods: This is a retrospective observational study carried out at Eye Hospital of Wenzhou Medical University, Zhejiang, China. Patients with uncontrolled glaucoma who underwent AGV implantation alone or combined with phacoemulsification (AGV-Phaco) in the hospital from April 1, 2013 to July 31, 2016 were included. Read More

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http://dx.doi.org/10.1186/s12886-019-1060-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368733PMC
February 2019
4 Reads
1.075 Impact Factor

ALTERATION OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN A PATIENT WITH OCULAR ISCHEMIC SYNDROME.

Retin Cases Brief Rep 2019 Feb 4. Epub 2019 Feb 4.

Department of Ophthalmology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Purpose: To analyze optical coherence tomography angiography images in ocular ischemic syndrome (OIS) before and after carotid artery stenting.

Methods: We report the case of an 80-year-old man with a history of hypertension and diabetes mellitus who developed OIS in the right eye due to right internal carotid artery stenosis 2 years earlier. After visual acuity declined in the left eye 2 years later, a neurosurgeon discovered left internal carotid artery stenosis, which led to the diagnosis of OIS in the left eye as well. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000857DOI Listing
February 2019
1 Read

Effect of Topical Periocular Steroid Use on Intraocular Pressure: A Retrospective Analysis.

Ophthalmic Plast Reconstr Surg 2019 Feb 4. Epub 2019 Feb 4.

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York, U.S.A.

Purpose: To study the effect of periocular steroid use on intraocular pressure (IOP).

Methods: Charts of adult patients with atopic dermatitis or eczema treated with topical periocular steroid creams and ointments from January 1st, 2007 to October 1st, 2017 were reviewed. Patients with the following were excluded: glaucoma, ocular hypertension, known systemic/topical/injectable steroid history, and lack of documented IOP prior to or during treatment with periocular steroid ointment. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001320DOI Listing
February 2019
3 Reads

Combined phacoemulsification and viscocanalostomy with Ologen implant versus combined phacoemulsification and viscocanalostomy.

BMC Ophthalmol 2019 Feb 6;19(1):45. Epub 2019 Feb 6.

Ophthalmology Department, Zagazig University, Zagazig, 44511, Egypt.

Background: To study the efficacy of the biodegradable collagen implant Ologen® as an adjuvant in phaco-viscocanalostomy in patients with coexisting cataract and primary open angle glaucoma.

Methods: This prospective, interventional, randomized clinical study was done at Alpha Vision Center, Zagazig, Egypt. Patients with coexisting cataract and glaucoma were randomized to receive either phaco-viscocanalostomy (Phacovisco group) (39 eyes) or phaco-viscocanalostomy with Ologen® implant (OloPhacovisco group) (40 eyes). Read More

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http://dx.doi.org/10.1186/s12886-019-1049-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364460PMC
February 2019
2 Reads
1.075 Impact Factor

Expression of matrix Metalloproteinases-2 and aquaporin-1 in corneoscleral junction after angle-closure in rabbits.

BMC Ophthalmol 2019 Feb 4;19(1):43. Epub 2019 Feb 4.

Department of Ophthalmology, Weifang Eye Hospital, Weifang, Shandong, People's Republic of China.

Background: To investigate the expression of Matrix Metalloproteinases 2 and aquaporin-1 in corneoscleral junction and explore the mechanism of trabecular damageafter angle-closure.

Methods: Thirty New Zealand white rabbits were randomly assigned into 2 groups, theexperimental group (Group 1) including twenty five rabbits and the control group (Group 2) including 5 rabbits. The rabbits in the experimental group were used to establish angle-closure models, and the rabbits in the control group were not subjected to any operation. Read More

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http://dx.doi.org/10.1186/s12886-019-1058-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360660PMC
February 2019
4 Reads

Intraocular pressure-lowering effects of imidazo[1,2-a]- and pyrimido[1,2-a]benzimidazole compounds in rats with dexamethasone-induced ocular hypertension.

Eur J Pharmacol 2019 Feb 1;850:75-87. Epub 2019 Feb 1.

International Medical University, IMU Clinical School, Seremban, Malaysia.

Ocular hypertension is believed to be involved in the etiology of primary open-angle glaucoma. Although many pharmaceutical agents have been shown to be effective for the reduction of intraocular pressure (IOP), a significant opportunity to improve glaucoma treatments remains. Thus, the aims of the present study were: (1) to evaluate the IOP-lowering effect of four compounds RU-551, RU-555, RU-839 (pyrimido[1,2-a]benzimidazole), and RU-615 (imidazo[1,2-a]benzimidazole) on steroid-induced ocular hypertension in rats after single drop and chronic applications; and (2) to test in silico and in vitro conventional rho-associated kinase (ROCK) inhibitory activity of the selected compound. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193008
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http://dx.doi.org/10.1016/j.ejphar.2019.01.059DOI Listing
February 2019
8 Reads

Treatment of canine postoperative ocular hypertension with combined latanoprost 0.005% and atropine 1% ophthalmic solutions.

Vet Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Department of Statistics, College of Natural Sciences, Colorado State University, Fort Collins, Colorado.

Objective: To compare the effects of topical 0.005% latanoprost (L) vs combined 0.005% latanoprost and 1% atropine (LA) on control of postoperative ocular hypertension (POH), development of posterior synechiae formation, pupil size, and blindness after phacoemulsification surgery in dogs. Read More

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http://dx.doi.org/10.1111/vop.12613DOI Listing
February 2019
1 Read

Prognostic Factors and Visual Outcomes of Pyogenic Liver Abscess-Related Endogenous Klebsiella pneumoniae Endophthalmitis: A 20-year retrospective review.

Sci Rep 2019 Jan 31;9(1):1071. Epub 2019 Jan 31.

Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Endogenous K. pneumoniae endophthalmitis (EKE) has a higher incidence among East Asians, and the most common infectious source of EKE is pyogenic liver abscess (PLA). We investigate the risk factors for poor visual outcomes in patients with PLA-related EKE. Read More

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http://dx.doi.org/10.1038/s41598-018-37643-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355790PMC
January 2019
3 Reads