63,539 results match your criteria Ocular Hypertension


Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model.

Cell Tissue Res 2022 May 20. Epub 2022 May 20.

Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, China.

Glaucoma is a neurodegenerative disease of visual system characterized by gradual loss of retinal ganglion cells (RGC). Since mitochondrial dysfunction of RGC is significantly involved in the pathological mechanisms of glaucoma, and hydrogen sulfide (HS) takes part in the pathogeny of glaucoma and shows promising potential in restoring mitochondrial function in other neurons, the authors aimed to investigate the impact of HS on mitochondrial function of RGC with a rat glaucoma model. An established chronic ocular hypertension (COH) rat model induced by injection of cross-linking hydrogel into anterior chamber was adopted, and a HS donor, sodium hydrosulfide (NaHS), was selected to treat rats through intraperitoneal injection. Read More

View Article and Full-Text PDF

[Visual Impairment and Eye Diseases in St. Louis, Senegal].

Med Trop Sante Int 2021 Jun 17;1(2). Epub 2021 Jun 17.

École d'optométrie, Université de Montréal, Québec, Canada.

Background: Few epidemiological data describe the prevalence of blindness and visual impairment in Senegal. Data from West African studies estimate blindness prevalence between 1.2 - 3. Read More

View Article and Full-Text PDF

[Haemorrhagic Stroke after Snakebite Envenomation Resulting in Irreversible Blindness in a 6-Year-Old Child in Mali].

Med Trop Sante Int 2021 Sep 29;1(3). Epub 2021 Jul 29.

Faculté de médecine et d'odontostomatologie, USTTB, Bamako, Mali.

Introduction: Snakebite envenomation can cause serious damage. Here, we report the case of a six-year-old male child bitten by a snake.

Clinical Description: The child presented a gingivorrhagia, abdominal pain, bloody vomiting and severe headache from a snakebite. Read More

View Article and Full-Text PDF
September 2021

Downregulation of angiogenic factors in aqueous humor associated with less intraoperative bleeding in PDR patients with NVG receiving conbercept: a randomized controlled trial.

BMC Ophthalmol 2022 May 18;22(1):224. Epub 2022 May 18.

Department of Ophthalmology, Xuzhou Eye Disease Prevention and Treatment Institute, Xuzhou First People's Hospital, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, 221116, Jiangsu Province, China.

Background: To analyze the level changes of 28 cytokines in aqueous humor of patients with proliferative diabetic retinopathy (PDR) coexisting neovascular glaucoma (NVG) after intravitreal injection of conbercept (IVC), and to investigate whether these cytokines are associated with intraoperative bleeding (IOB).

Methods: Totally 34 eyes with NVG secondary to PDR were enrolled. Patients were randomized into two groups, and all of them underwent 25-gauge pars plana vitrectomy (PPV) combined with trabeculectomy. Read More

View Article and Full-Text PDF

Short and long-term effect of dexamethasone on the transcriptome profile of primary human trabecular meshwork cells in vitro.

Sci Rep 2022 May 18;12(1):8299. Epub 2022 May 18.

Department of Ocular Pharmacology, Aravind Medical Research Foundation, #1, Anna Nagar, Madurai, Tamil Nadu, 625020, India.

In the quest of identifying newer molecular targets for the management of glucocorticoid-induced ocular hypertension (GC-OHT) and glaucoma (GCG), several microarray studies have attempted to investigate the genome-wide transcriptome profiling of primary human trabecular meshwork (TM) cells in response to dexamethasone (DEX). However, no studies are reported so far to demonstrate the temporal changes in the expression of genes in the cultured human TM cells in response to DEX treatment. Therefore, in the present study, the time-dependent changes in the genome-wide expression of genes in primary human TM cells after short (16 hours: 16 h) and long exposure (7 days: 7 d) of DEX was investigated using RNA sequencing. Read More

View Article and Full-Text PDF

Contrast-to-Noise Ratios to Evaluate the Detection of Glaucomatous Progression in the Superior and Inferior Hemiretina.

Transl Vis Sci Technol 2022 May;11(5):20

Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands.

Purpose: To determine the sensitivity of optical coherence tomography (OCT) and standard automated perimetry (SAP) for detecting glaucomatous progression in the superior and inferior hemiretina.

Methods: We calculated contrast-to-noise ratios (CNRs) for OCT retinal nerve fiber layer (RNFL) thickness of hemiretinas and for SAP mean total deviation (MTD) of the corresponding hemifields from longitudinal data (205 eyes, 125 participants). The glaucoma stage for each hemiretina was based on the corresponding hemifield's MTD. Read More

View Article and Full-Text PDF

Evaluation of Suspected Autosomal Alport Syndrome Synonymous Variants.

Kidney360 2022 Mar 13;3(3):497-505. Epub 2021 Oct 13.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Alport syndrome is an inherited disorder characterized by progressive renal disease, variable sensorineural hearing loss, and ocular abnormalities. Although many pathogenic variants in and have been identified in patients with autosomal Alport syndrome, synonymous mutations in these genes have rarely been identified.

Methods: We conducted splicing analysis using Human Splicing Finder (HSF) and Alamut to predict splicing domain strength and disruption of the sites. Read More

View Article and Full-Text PDF

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure.

Nat Commun 2022 May 17;13(1):2556. Epub 2022 May 17.

State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China.

Engineering wearable devices that can wirelessly track intraocular pressure and offer feedback-medicine administrations are highly desirable for glaucoma treatments, yet remain challenging due to issues of limited sizes, wireless operations, and wireless cross-coupling. Here, we present an integrated wireless theranostic contact lens for in situ electrical sensing of intraocular pressure and on-demand anti-glaucoma drug delivery. The wireless theranostic contact lens utilizes a highly compact structural design, which enables high-degreed integration and frequency separation on the curved and limited surface of contact lens. Read More

View Article and Full-Text PDF

Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series.

BMC Vet Res 2022 May 16;18(1):182. Epub 2022 May 16.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.

Background: A number of etiologies for different canine chorioretinal lesions have been proved or suggested but some fundic lesions remain unclear in terms of an etiologic diagnosis, treatment options and prognosis. The purpose of this case series is to describe atypical chorioretinal lesions observed in dogs with primary angle-closure glaucoma (PACG).

Case Presentation: Two spayed-female Siberian Huskies (3- and 4-year-old) and one Siberian Husky/Australian Shepherd mixed breed dog (11-month-old) that had multifocal depigmented retinal lesions and PACG were included. Read More

View Article and Full-Text PDF

Biometric indicators of anterior segment parameters before and after laser peripheral iridotomy by swept-source optical coherent tomography.

BMC Ophthalmol 2022 May 16;22(1):222. Epub 2022 May 16.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Nankai District, No. 251, Fukang Road, Tianjin, 300384, China.

Background: Primary angle closure glaucoma (PACG) is the most common type of glaucoma in China. Laser peripheral iridotomy (LPI) is the primary choice to treat PAC: We aim to evaluate the changes of biometric parameters of anterior segment and to find possible biometric predictors of the effect of laser peripheral iridotomy (LPI) in primary angle closure (PAC) eyes using swept-source optical coherent tomography (OCT).

Methods: LPI was performed in 52 PAC eyes of 28 participants. Read More

View Article and Full-Text PDF

Glaucoma diagnosis using multi-feature analysis and a deep learning technique.

Sci Rep 2022 May 16;12(1):8064. Epub 2022 May 16.

School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, 2052, Australia.

In this study, we aimed to facilitate the current diagnostic assessment of glaucoma by analyzing multiple features and introducing a new cross-sectional optic nerve head (ONH) feature from optical coherence tomography (OCT) images. The data (n = 100 for both glaucoma and control) were collected based on structural, functional, demographic and risk factors. The features were statistically analyzed, and the most significant four features were used to train machine learning (ML) algorithms. Read More

View Article and Full-Text PDF

Home monitoring of glaucoma using a home tonometer and a novel virtual reality visual field device: acceptability and feasibility.

Ophthalmol Glaucoma 2022 May 13. Epub 2022 May 13.

New York University Langone Health Department of Ophthalmology; New York University Langone Health Department of Population Health. Electronic address:

Objective: Our aim is to assess acceptability and feasibility of iCare HOME (HT) and Virtual Field (VF) in the home monitoring of glaucoma.

Design: Prospective feasibility and acceptability study SUBJECTS: 20 patients (39 eyes) with primary open angle glaucoma, open-angle glaucoma, ocular hypertension, or suspected glaucoma METHODS: Patients were trained and instructed to bring two devices home for 1 week and use the HT 4 times/day for 4 days and the VF 3 times total.

Main Outcome Measures: For acceptability, we conducted satisfaction surveys and semi-structured qualitative interviews with thematic analysis. Read More

View Article and Full-Text PDF

Retrospective Study of Long-Term Outcome of Phacoemulsification in 22 Feline Eyes with Presumed Congenital/Juvenile Cataracts (2007-2020).

J Am Anim Hosp Assoc 2022 May;58(3):121-128

From MedVet, Columbus, Ohio (T.W.).

The objective of this study was to determine the complication risk and prevalence after phacoemulsification in cats with presumed congenital/inherited cataracts. Twelve client-owned cats were included in the study. This retrospective study spanned 13 yr and involved 22 eyes. Read More

View Article and Full-Text PDF

Ultrasound Targeted Microbubble Destruction Promotes the Therapeutic Effect of HUMSC Transplantation on Glaucoma-Caused Optic Nerve Injury in Rabbits.

Transl Vis Sci Technol 2022 May;11(5):12

Department of Ophthalmology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.

Purpose: The purpose of this study was to explore the therapeutic effect of human umbilical cord mesenchymal stem cell (HUMSC) transplantation alone or assisted with ultrasound targeted microbubble destruction (UTMD) on optic neuropathy in a novel and practical model of experimental glaucoma in rabbits.

Methods: Eight New Zealand white healthy rabbits were used as the control group (group A). Twenty-four experimental glaucomatous rabbits were established as described previously and randomly divided into three groups: (1) received no treatment (group B); (2) received intravitreal transplantation of HUMSCs (group C); and (3) received UTMD-assisted intravitreal transplantation of HUMSCs (group D). Read More

View Article and Full-Text PDF

Modeling the Effects of Disease, Drug Properties, and Material on Drug Transport From Intraocular Lenses.

Transl Vis Sci Technol 2022 May;11(5):14

Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada.

Purpose: Surgically implanted intraocular lenses (IOLs) may be used as drug-delivery devices, but their effectiveness is not well defined. Computational fluid dynamics models were developed to investigate the capability of IOLs to release drugs at therapeutic concentrations.

Methods: Models were generated using COMSOL Multiphysics. Read More

View Article and Full-Text PDF

Idiopathic combined retinal vessels occlusion in a pregnant woman: a case report.

J Med Case Rep 2022 May 15;16(1):191. Epub 2022 May 15.

Obstetrics and Gynecology Department, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Ocular vascular occlusion is an extremely rare event, especially in the young population. This diagnosis is always associated with active systemic diseases in young adults and needs thrombophilia workup. Nevertheless, we present the case of a pregnant woman suffering from idiopathic combined central retinal vein and cilioretinal artery occlusion. Read More

View Article and Full-Text PDF

The analysis of the glaucoma screening event results obtained during the World Glaucoma Week in Zagreb, Croatia.

Int Ophthalmol 2022 May 14. Epub 2022 May 14.

University Department of Ophthalmology and Optometry, Sestre Milosrdnice University Hospital Center, Vinogradska 29, Zagreb, Croatia.

Purpose: To report the prevalence of undiagnosed glaucoma, as well as demographic characteristics and risk factors among glaucoma suspects who were detected in a publicly promoted intraocular pressure (IOP) based glaucoma screening event.

Methods: A total of 2468 subjects older than 18 years participated in the glaucoma screening event in Zagreb, in 2014, which included a medical interview and IOP measurement using Icare tonometer. 256 subjects (10. Read More

View Article and Full-Text PDF

Increased Complement-Associated Inflammation in Cytomegalovirus-Positive Hypertensive Anterior Uveitis Patients Based on the Aqueous Humor Proteomics Analysis.

J Clin Med 2022 Apr 22;11(9). Epub 2022 Apr 22.

Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA.

Herpetic anterior uveitis-associated ocular inflammation is commonly manifested with ocular hypertension and glaucoma. Relative to other viruses, cytomegalovirus (CMV) positive hypertensive anterior uveitis is associated with high recurrences of uveitis, as well as with uncontrolled intraocular pressure (IOP) and a subsequent higher requirement for future glaucoma surgery. To gain novel insights into the pathogenesis of ocular hypertension in these patients, we investigated the proteome changes of the aqueous humor (AH) derived from the CMV hypertensive anterior uveitis (CMV-HAU; = 10) patients and non-glaucoma (cataract; = 10) patients using liquid chromatography with tandem mass spectrometry. Read More

View Article and Full-Text PDF

Reciprocal Regulation between lncRNA ANRIL and p15 in Steroid-Induced Glaucoma.

Cells 2022 Apr 27;11(9). Epub 2022 Apr 27.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Steroid-induced glaucoma (SIG) is the most common adverse steroid-related effect on the eyes. SIG patients can suffer from trabecular meshwork (TM) dysfunction, intraocular pressure (IOP) elevation, and irreversible vision loss. Previous studies have mainly focused on the role of extracellular matrix turnover in TM dysfunction; however, whether the cellular effects of TM cells are involved in the pathogenesis of SIG remains unclear. Read More

View Article and Full-Text PDF

Statins Inhibit the Gliosis of MIO-M1, a Müller Glial Cell Line Induced by TRPV4 Activation.

Int J Mol Sci 2022 May 6;23(9). Epub 2022 May 6.

Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul 05505, Korea.

We characterized Müller cell gliosis induced by the activation of transient receptor potential vanilloid-type 4 (TRPV4) and assessed whether statins could modulate the gliosis. The human Müller cell line, MIO-M1, was used to analyze the gliosis caused by glaucomatous stimulation. To induce Müller gliosis in MIO-M1 cells, GSK101 was used to activate TRPV4, and Müller gliosis was evaluated by analyzing vimentin, nestin, and glial fibrillary acidic protein (GFAP) expression. Read More

View Article and Full-Text PDF

Deep Learning for Glaucoma Detection and Identification of Novel Diagnostic Areas in Diverse Real-World Datasets.

Transl Vis Sci Technol 2022 May;11(5):11

Matroid, Palo Alto, CA, USA.

Purpose: To develop a three-dimensional (3D) deep learning algorithm to detect glaucoma using spectral-domain optical coherence tomography (SD-OCT) optic nerve head (ONH) cube scans and validate its performance on ethnically diverse real-world datasets and on cropped ONH scans.

Methods: In total, 2461 Cirrus SD-OCT ONH scans of 1012 eyes were obtained from the Glaucoma Clinic Imaging Database at the Byers Eye Institute, Stanford University, from March 2010 to December 2017. A 3D deep neural network was trained and tested on this unique raw OCT cube dataset to identify a multimodal definition of glaucoma excluding other concomitant retinal disease and optic neuropathies. Read More

View Article and Full-Text PDF

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.

Nat Genet 2022 May 12;54(5):560-572. Epub 2022 May 12.

Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.

We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 × 10), which were delineated to 338 distinct association signals. Read More

View Article and Full-Text PDF

Vision-related quality of life in patients with glaucoma: the role of illness perceptions.

Health Qual Life Outcomes 2022 May 12;20(1):78. Epub 2022 May 12.

The Eye Hospital, Wenzhou Medical University, 270 Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang Province, China.

Purpose: To explore the predictive effects of illness perceptions on vision-related quality of life (VRQoL) in Chinese glaucoma patients.

Methods: In this cross-sectional study, 97 patients with glaucoma completed the brief illness perception questionnaire (BIPQ), the glaucoma quality of life-15 (GQL-15) questionnaire, and a questionnaire regarding sociodemographic and clinical information. A correlation analysis and hierarchical linear regression analysis were performed. Read More

View Article and Full-Text PDF

Effects of optic nerve head-related parameters on retinal vessel calibers measurement results on fundus photographs.

BMC Ophthalmol 2022 May 12;22(1):215. Epub 2022 May 12.

Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Setagaya-ku, Tokyo, Japan.

Background: Although relationship between the retinal vessel caliber (RVC) and glaucoma is well known, there has been a paucity of information on the effects of glaucoma-related optic nerve head (ONH) structural factors on the RVC. Information on this relationship should be useful in studying possible roles of ocular circulation in the development and progression of glaucoma.

Method: Subjects were from Kumejima Study participants aged 40 years and older in Kumejima, Japan. Read More

View Article and Full-Text PDF

Segmentation of Optic Disc and Cup Using Modified Recurrent Neural Network.

Biomed Res Int 2022 2;2022:6799184. Epub 2022 May 2.

Department of Chemical Engineering, College of Biological and Chemical Engineering, Addis Ababa Science and Technology University, Ethiopia.

Glaucoma is one of the leading factors of vision loss, where the people tends to lose their vision quickly. The examination of cup-to-disc ratio is considered essential in diagnosing glaucoma. It is hence regarded that the segmentation of optic disc and cup is useful in finding the ratio. Read More

View Article and Full-Text PDF

Evaluation of Spatially Targeted Scleral Stiffening on Neuroprotection in a Rat Model of Glaucoma.

Transl Vis Sci Technol 2022 May;11(5)

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.

Purpose: Scleral stiffening may protect against glaucomatous retinal ganglion cell (RGC) loss or dysfunction associated with ocular hypertension. Here, we assess the potential neuroprotective effects of two treatments designed to stiffen either the entire posterior sclera or only the sclera adjacent to the peripapillary sclera in an experimental model of glaucoma.

Methods: Rat sclerae were stiffened in vivo using either genipin (crosslinking the entire posterior sclera) or a regionally selective photosensitizer, methylene blue (stiffening only the juxtaperipapillary region surrounding the optic nerve). Read More

View Article and Full-Text PDF

Validation of the RCOphth and UKEGS glaucoma risk stratification tool 'GLAUC-STRAT-fast'.

Br J Ophthalmol 2022 May 9. Epub 2022 May 9.

Glaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK

Background/aims: The aim of this study was to validate the Glaucoma Risk Stratification Tool (GLAUC-STRAT-fast) currently recommended by the Royal College of Ophthalmologists for the risk stratification of patients with glaucoma in the UK National Health Service Hospital Eye Service.

Methods: GLAUC-STRAT fast was applied to the LiGHT trial participants by risk-stratifying the worse eye of each patient at baseline and after 3 years of treatment. Metrics of disease severity or treatment intensity used for the validation were: increased number of monitoring visits or treatment escalations; needing a trabeculectomy; a reduction of >2 dB in visual field mean deviation (VF MD) during the monitoring period; identification of rapid VF loss on total (TD) and/or pattern deviation (PD). Read More

View Article and Full-Text PDF

The New Era of Retinal Imaging in Hypertensive Patients.

Asia Pac J Ophthalmol (Phila) 2022 Mar-Apr 01;11(2):149-159

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Abstract: Structural and functional alterations in the microcirculation by systemic hypertension can cause significant organ damage at the eye, heart, brain, and kidneys. As the retina is the only tissue in the body that allows direct imaging of small vessels, the relationship of hypertensive retinopathy signs with development of disease states in other organs have been extensively studied; large-scale epidemiological studies using fundus photography and advanced semi-automated analysis software have reported the association of retinopathy signs with hypertensive end-organ damage includes the following: stroke, dementia, and coronary heart disease. Although yielding much useful information, the vessels assessed from fundus photographs remain limited to the larger retinal arterioles and venules, and abnormalities observed may not be that of the earliest changes. Read More

View Article and Full-Text PDF

Clinical and Radiological Profile of 122 Cases of Idiopathic Intracranial Hypertension in a Tertiary Care Centre of India: An Observational Study.

Neurol India 2022 Mar-Apr;70(2):704-709

Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India.

Background: Idiopathic intracranial hypertension (IIH) is well-described entity in literature. However, large studies on clinical and radiological profile are still very few from the Indian subcontinent.

Aims: To analyze the clinical and radiological profile of IIH and correlation of various clinical and radiological parameters with papilledema and CSF opening pressure. Read More

View Article and Full-Text PDF