57,835 results match your criteria Ocular Hypertension


Evaluation of a Primary Open-Angle Glaucoma Prediction Model Using Long-term Intraocular Pressure Variability Data: A Secondary Analysis of 2 Randomized Clinical Trials.

JAMA Ophthalmol 2020 Jun 4. Epub 2020 Jun 4.

Department of Oncology, Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy.

Importance: The contribution of long-term intraocular pressure (IOP) variability to the development of primary open-angle glaucoma is still controversial.

Objective: To assess whether long-term IOP variability data improve a prediction model for the development of primary open-angle glaucoma (POAG) in individuals with untreated ocular hypertension.

Design, Setting, And Participants: This post hoc secondary analysis of 2 randomized clinical trials included data from 709 of 819 participants in the observation group of the Ocular Hypertension Treatment Study (OHTS) followed up from February 28, 1994, to June 1, 2002, and 397 of 500 participants in the placebo group of the European Glaucoma Prevention Study (EGPS) followed up from January 1, 1997, to September 30, 2003. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2020.1902DOI Listing

Contributing ocular comorbidity to end-of-life visual acuity in medically treated glaucoma patients, ocular hypertension and glaucoma suspect patients.

Eye (Lond) 2020 Jun 3. Epub 2020 Jun 3.

University Eye Clinic Maastricht, Maastricht, The Netherlands.

Aim: To assess the visual acuity at the end of life in glaucoma suspect patients, ocular hypertension, and patients treated for glaucoma and to find factors contributing to a reduced visual acuity in this cohort of deceased patients.

Methods: In a cohort of 3883 medically treated glaucoma patients, glaucoma suspect, or patients with ocular hypertension assembled in 2001-2004, 1639 were deceased. Patient data were collected from electronic and paper patient files. Read More

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http://dx.doi.org/10.1038/s41433-020-0991-0DOI Listing

Analysis of Plasma Hydrogen Sulfide, Homocysteine, and L-Cysteine in Open-Angle Glaucoma Patients.

J Ocul Pharmacol Ther 2020 Jun 3. Epub 2020 Jun 3.

Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, China.

To compare the plasma levels of hydrogen sulfide (HS), homocysteine (Hcy), and L-cysteine (Cys) among primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), ocular hypertension (OHT), and normal individuals. To explore associated factors and evaluate their diagnostic abilities in glaucoma. POAG, NTG, OHT, and normal subjects were recruited from Ruijin Hospital between December 2016 and December 2018. Read More

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http://dx.doi.org/10.1089/jop.2020.0023DOI Listing

Ocular flare-up in patients with systemic lupus erythematosus following discontinuation of hydroxychloroquine.

Lupus 2020 Jun 2:961203320928409. Epub 2020 Jun 2.

Retina Service, Farabi Eye Hospital, Ophthalmology Department, Tehran University of Medical Sciences, Tehran, Iran.

In this report, we describe two patients with systemic lupus erythematosus (SLE) who manifested with posterior segment flare-up approximately three months after cessation of hydroxychloroquine (HCQ). They were stable systemically with no history of hypertension or nephropathy at the time of referral. Our first patient presented with bilateral retinal vein occlusion, while evidence of choroidal involvement such as vascular leakage and wedge-shaped filling delay was present in indocyanine green angiography of both patients. Read More

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http://dx.doi.org/10.1177/0961203320928409DOI Listing

Medical management of pediatric glaucoma: lessons learned from randomized clinical trials.

Graefes Arch Clin Exp Ophthalmol 2020 Jun 2. Epub 2020 Jun 2.

University Eye Clinic, San Giuseppe Hospital, University of Milan, Via San Vittore 12, 20123, Milan, Italy.

Purpose: To critically discuss the randomized clinical trials (RCTs) on glaucoma medical therapy for the management of pediatric glaucoma.

Methods: RCTs on glaucoma drugs carried out on pediatric subjects with ocular hypertension and glaucoma were identified through systematic searches. The methods of the RCTs and the safety and the efficacy of the glaucoma drugs were reviewed and discussed. Read More

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http://dx.doi.org/10.1007/s00417-020-04767-9DOI Listing

Contemporary Outcomes and Prognostic Factors of 23-Gauge Vitrectomy for Retained Lens Fragments after Phacoemulsification.

Am J Ophthalmol 2020 May 29. Epub 2020 May 29.

Vitreoretinal Service, Moorfields Eye Hospital, London, United Kingdom. Electronic address:

Purpose: To provide data on VA outcomes and prognostic factors of micro-incision 23-gauge vitrectomy (MIVS) for retained lens fragments after complicated cataract surgery.

Design: Retrospective, interventional case series from 2012 to 2017.

Methods: Pre-cataract surgery and intra-operative (vitrectomy) parameters, post-vitrectomy complications, and best-corrected visual acuities (BCVA), were identified. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.028DOI Listing

Evaluation of Ophthalmology Inpatients Consultation in a Nigerian Tertiary Eye Care Centre.

West Afr J Med 2020 Jul-Aug;37(3):221-224

Department of Ophthalmology, University of Benin Teaching Hospital, Benin City, Nigeria.

Background: Ophthalmology consultations are more thorough on outpatient basis, but inpatient evaluation cannot be over looked especially in terms of care of patients admitted in other specialties.

Objectives: This is to assess the profile of inpatient consultation and eye problems evaluated and managed by the ophthalmology department of the University of Benin Teaching Hospital, Benin City, Nigeria.

Methods: All consecutive inpatients who had ophthalmic consultations requested for by various departments in the hospital between July 2018 and June 2019. Read More

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The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons.

Kidney Int 2020 Feb 27. Epub 2020 Feb 27.

University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK; Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK. Electronic address:

Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Read More

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http://dx.doi.org/10.1016/j.kint.2020.01.039DOI Listing
February 2020

Visual impairment in pseudoexfoliation from four tertiary centres in India.

PLoS One 2020 29;15(5):e0233268. Epub 2020 May 29.

Glaucoma Service, LV Prasad Eye Institute, Vijayawada, Andhra Pradesh, India.

Purpose: To analyse the disease burden of pseudoexfoliation (PXF) disease stages from East and South India.

Design: Prospective hospital based study of patients seen at 4 tertiary centres.

Subjects, Participants, And/or Controls: Consecutive old and new patients of pseudoexfoliation with normal intraocular pressure (IOP), raised IOP (PXF with Ocular hypertension, OHT) and irreversible disc/field changes (pseudoexfoliation glaucoma, PXG) seen from April 2016-March 2017 at a tertiary centre in Odisha, East India and 3 centres in Andhra Pradesh and Telangana, South India, recruited into the prospective study were screened for baseline characteristics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233268PLOS

Ocular Ultrasonography to Detect Intracranial Hypertension in Subarachnoid Hemorrhage Patients.

Neurocrit Care 2020 May 28. Epub 2020 May 28.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via Allende, 84081, Baronissi, Salerno, Italy.

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http://dx.doi.org/10.1007/s12028-020-00999-zDOI Listing

The Authors Reply: Ocular Ultrasonography to Detect Intracranial Hypertension in Subarachnoid Hemorrhage Patients.

Neurocrit Care 2020 May 27. Epub 2020 May 27.

Neuroscience Intensive Care Unit, Department of Anesthesia and Critical Care, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1007/s12028-020-01000-7DOI Listing

An update on idiopathic intracranial hypertension in adults: a look at pathophysiology, diagnostic approach and management.

J Neurol 2020 May 27. Epub 2020 May 27.

Department "GF Ingrassia", Section of Neurosciences, University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.

Idiopathic intracranial hypertension is a neurological syndrome determined by a rise in intracranial pressure without a detectable cause. Course and prognosis may be changeable, requiring a multidisciplinary approach for its diagnosis and management. Although its precise pathogenesis is still unknown, many studies have been carried out to define the possible causal and associated factors, such as retinoids, steroid hormones, body mass index and recent weight gains, cytokines and adipokines levels. Read More

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http://dx.doi.org/10.1007/s00415-020-09943-9DOI Listing

Activation of adenosine A receptor protects retinal ganglion cells from degeneration induced by ocular hypertension.

Cell Death Dis 2020 May 27;11(5):401. Epub 2020 May 27.

University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Coimbra, Portugal.

Glaucoma is a progressive chronic retinal degenerative disease and a leading cause of global irreversible blindness. This disease is characterized by optic nerve damage and retinal ganglion cell (RGC) death. The current treatments available target the lowering of intraocular pressure (IOP), the main risk factor for disease onset and development. Read More

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http://dx.doi.org/10.1038/s41419-020-2593-yDOI Listing

Sanitization of glaucoma clinic instruments in COVID-19 era.

Indian J Ophthalmol 2020 06;68(6):1225

Shreeji Eye Clinic and Palak's Glaucoma Care Centre, Samrat Bldg, Andheri (E), Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/ijo.IJO_1423_20DOI Listing

Does Bariatric Surgery Affect Intraocular Pressure?

Obes Surg 2020 May 26. Epub 2020 May 26.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: The effect of body mass index (BMI) reduction following bariatric surgery on intraocular pressure (IOP) is not well established. We evaluated association between BMI reduction and IOP measurements and other ocular and metabolic parameters 1 year after bariatric surgery.

Materials And Methods: A retrospective study with over 1-year follow-up on patients who underwent weight reduction bariatric surgery between January 2016 and December 2016 at Wolfson Medical Center, Israel. Read More

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http://dx.doi.org/10.1007/s11695-020-04714-xDOI Listing

Identifying outcomes that are important to patients with ocular hypertension or primary open-angle glaucoma: a qualitative interview study.

Ophthalmol Glaucoma 2019 Nov-Dec;2(6):374-382. Epub 2019 Jul 31.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Purpose: To explore patients' perspectives and experiences living with glaucoma and identify important benefits and risks that patients consider before electing for new glaucoma treatments, such as minimally invasive glaucoma surgical (MIGS) devices.

Design: Semi-structured, in-person qualitative interviews with patients seen at the Johns Hopkins Wilmer Eye Institute.

Participants: Adults older than 21 years of age who were suspected or diagnosed with ocular hypertension or mild to moderate primary open-angle glaucoma (POAG) (and thus eligible for treatment with a MIGS procedure) presenting to a glaucoma clinic in Baltimore, Maryland, between May and December 2016. Read More

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http://dx.doi.org/10.1016/j.ogla.2019.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243613PMC

Preoperative Steroid Use in Rhegmatogenous Retinal Detachment Associated with Choroidal Detachment after 23-Gauge Vitrectomy.

J Ophthalmol 2020 2;2020:6707239. Epub 2020 May 2.

Retinal & Vitreous Diseases Department of Wuhan Aier Eye Hospital, Aier Ophthalmic College of Central-South University, Wuhan 430064, China.

Background: Rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD) is rare and the prognosis is poor. This retrospective study evaluated the effect of preoperative steroid on the clinical outcome of patients with RRDCD receiving 23-gauge pars plana vitrectomy (PPV).

Methods: Sixty-six patients (67 eyes) with diagnosed RRDCD underwent 23-gauge PPV. Read More

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http://dx.doi.org/10.1155/2020/6707239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222551PMC

Pediatric Sympathetic Ophthalmia: 20 Years of Data From a Tertiary Eye Center in India.

J Pediatr Ophthalmol Strabismus 2020 May;57(3):154-158

Purpose: To examine the clinical profile of sympathetic ophthalmia among the pediatric age group.

Methods: Retrospective review of patients 18 years and younger with sympathetic ophthalmia seen in a tertiary eye care center between 1997 and 2017.

Results: Of 20 patients included in the study, 70% were male. Read More

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http://dx.doi.org/10.3928/01913913-20200219-01DOI Listing

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice.

Mol Brain 2020 May 25;13(1):81. Epub 2020 May 25.

The Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, ME, USA.

Glaucoma is the leading cause of irreversible vision loss. Ocular hypertension is a major risk factor for glaucoma and recent work has demonstrated critical early neuroinflammatory insults occur in the optic nerve head following ocular hypertension. Microglia and infiltrating monocytes are likely candidates to drive these neuroinflammatory insults. Read More

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http://dx.doi.org/10.1186/s13041-020-00603-7DOI Listing

[The effects and mechanism of baicalin in a mouse acute hypertensive glaucoma model].

Zhonghua Yan Ke Za Zhi 2020 May;56(5):376-382

Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, China.

To explore the potential neuroprotection effects and associated mechanism of baicalin in a rodent acute hypertensive glaucoma model and oxygen-glucose deprivation/reperfusion (OGD/R) induced retinal ganglion cell (RGC) injury. Experiment research. A rapid and substantial elevation of intraocular pressure was performed to establish an acute hypertensive glaucoma model, and retinal thickness was assessed at 1, 3, 5, and 7 days. Read More

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http://dx.doi.org/10.3760/cma.j.cn112142-20200107-00011DOI Listing

Coronaviruses pathogenesis, comorbidities and multi-organ damage - A review.

Life Sci 2020 May 22;255:117839. Epub 2020 May 22.

Department of Biomedical Sciences, School of Biosciences and Technology, VIT, Vellore, Tamil Nadu 632014, India. Electronic address:

Human coronaviruses, especially COVID-19, is an emerging pandemic infectious disease with high morbidity and mortality. Coronaviruses are associated with comorbidities, along with the symptoms of it. SARS-CoV-2 is one of the highly pathogenic coronaviruses that causes a high death rate compared to the SARS-CoV and MERS. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243768PMC

Bimatoprost Implant: First Approval.

Authors:
Matt Shirley

Drugs Aging 2020 May 23. Epub 2020 May 23.

Springer Nature, Private Bag 65,901, Mairangi Bay, Auckland, 0754, New Zealand.

Bimatoprost implant (Durysta™), developed by Allergan, is a sustained-release drug delivery system containing bimatoprost, a prostaglandin analogue with ocular hypotensive activity. The implant, administered intracamerally, involves the use of a biodegradable, solid polymer drug delivery system for slow, sustained drug release, designed to lower intraocular pressure (IOP) over a 4- to 6-months period. In March 2020, bimatoprost implant received its first approval, in the USA, for use to reduce IOP in patients with open angle glaucoma (OAG) or ocular hypertension (OHT). Read More

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http://dx.doi.org/10.1007/s40266-020-00769-8DOI Listing

Modified Intraocular Lens Intrascleral Fixation Technique Using Two Vitrectomy Ports as Lens Haptic Fixation Sites.

Clin Ophthalmol 2020 6;14:1223-1228. Epub 2020 May 6.

Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.

Introduction: We developed a new technique that uses two of the vitrectomy ports as intraocular lens (IOL) haptic fixation sites and compared that with a conventional T-fixation method.

Methods: A total of 33 eyes were retrospectively divided into the port-fixation (n=21) and conventional (n=12) groups. For the port-fixation group, supranasal and inferotemporal trocars (25-gauge) were placed in the center of a T-shaped lamellar scleral incision 2 mm from the corneal limbus and a supratemporal trocar at 3. Read More

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http://dx.doi.org/10.2147/OPTH.S247920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212690PMC

Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination.

Clin Ophthalmol 2020 4;14:1207-1214. Epub 2020 May 4.

Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan.

Purpose: To investigate the short-term intraocular pressure-lowering efficacy and safety of switching from a fixed combination of latanoprost/timolol to a fixed combination of latanoprost/carteolol.

Patients And Methods: The subjects were 30 eyes of 30 adult patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who were using a latanoprost-/timolol-fixed combination with insufficient intraocular pressure-lowering efficacy or adverse reactions. The subjects were switched from once-daily latanoprost/timolol to once-daily latanoprost/carteolol with no washout interval. Read More

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http://dx.doi.org/10.2147/OPTH.S240425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210024PMC

Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics.

Proc Natl Acad Sci U S A 2020 May 21. Epub 2020 May 21.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;

The conventional outflow pathway is a complex tissue responsible for maintaining intraocular pressure (IOP) homeostasis. The coordinated effort of multiple cells with differing responsibilities ensures healthy outflow function and IOP maintenance. Dysfunction of one or more resident cell types results in ocular hypertension and risk for glaucoma, a leading cause of blindness. Read More

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http://dx.doi.org/10.1073/pnas.2001896117DOI Listing

Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT.

J Clin Med 2020 May 16;9(5). Epub 2020 May 16.

Department of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, Spain.

The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and fifty-seven eyes of 57 early POAG patients were included. The thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform and nuclear layer, photoreceptor layer (PRL) and retinal pigment epithelium were obtained in 64 cells for each macular layer and mean thickness of superior and inferior hemispheres was also calculated. Read More

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http://dx.doi.org/10.3390/jcm9051503DOI Listing

Effects of shell thickness of hollow poly(lactic acid) nanoparticles on sustained drug delivery for pharmacological treatment of glaucoma.

Acta Biomater 2020 May 16. Epub 2020 May 16.

Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan, ROC; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan, ROC. Electronic address:

Structural designing of carriers with extended drug release profiles is critically important for achieving long-acting drug delivery systems toward efficient managements of chronic diseases. Here, we present a strategy to exploit the effects of the shell thickness of hollow poly(lactic acid) nanoparticles (HPLA NPs) in sustained glaucoma therapy. Formulations based on pilocarpine-loaded HPLA NPs with tailorable shell thickness ranging from 10 to 100 nm were shown to be highly compatible with human lens epithelial cells in vitro and with rabbit eyes in vivo. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.04.055DOI Listing

ABCA1 Regulates IOP by Modulating Cav1/eNOS/NO Signaling Pathway.

Invest Ophthalmol Vis Sci 2020 May;61(5):33

,.

Purpose: This study aimed to investigate the role and pathophysiological mechanism of ATP binding cassette transporter A1 (ABCA1) in regulating the IOP and aqueous humor outflow.

Methods: ABCA1 expression was measured in trabecular meshwork samples obtained from patients with POAG and human donor eyes by Western blot. To further evaluate the functional significance of ABCA1, porcine angular aqueous plexus (AAP) cells, which are equivalent to human Schlemm's canal endothelial cells, were either treated with ABCA1 agonist GW3965 or transduced with lentivirus expressing ABCA1-shRNA. Read More

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http://dx.doi.org/10.1167/iovs.61.5.33DOI Listing

Anti-glaucoma potential of hesperidin in experimental glaucoma induced rats.

AMB Express 2020 May 18;10(1):94. Epub 2020 May 18.

Department of Ophthalmology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Xuzhou Medical University Affiliated Hospital of Lianyungang, The First People's Hospital of Lianyungang, No. 6 Zhenhua East Road, Haizhou District, Lianyungang, 222002, China.

Glaucoma is well-known clinical eye conditions that damage the optic nerve due to abnormal pressure conditions in eye. Hesperidin is well-known glycoside widely present in the citrus fruits, and its aglycone form is known as hesperetin. Hesperidin is major flavone found in orange fruits. Read More

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http://dx.doi.org/10.1186/s13568-020-01027-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235152PMC

Open angle glaucoma secondary to endogenous cortisone due to pituitary microadenoma in a young patient, a case report.

Arch Soc Esp Oftalmol 2020 May 15. Epub 2020 May 15.

Departamento de Oftalmología, Hospital Puerta de Hierro Majadahonda, Madrid, España; Departamento de Oftalmología, Universidad de Castilla La Mancha, Albacete, España.

Case Report: A 31-year-old male was referred for evaluation after being diagnosed with Cushing syndrome secondary to a pituitary microadenoma. He presented with a reduced visual acuity and high intraocular pressure (IOP) of 48mmHg in both eyes. The examination with biomicroscopy showed normal anterior segment, increased cup to disc ratio, and open angle. Read More

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http://dx.doi.org/10.1016/j.oftal.2020.03.008DOI Listing

MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma.

Neurobiol Dis 2020 May 15;141:104944. Epub 2020 May 15.

Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States of America. Electronic address:

Improving cellular access to energy substrates is one strategy to overcome observed declines in energy production and utilization in the aged and pathologic central nervous system. Monocarboxylate transporters (MCTs), the movers of lactate, pyruvate, and ketone bodies into or out of a cell, are significantly decreased in the DBA/2 J mouse model of glaucoma. In order to confirm MCT decreases are disease-associated, we decreased MCT2 in the retinas of MCT2 mice using an injection of AAV2-cre, observing significant decline in ATP production and visual evoked potential. Read More

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http://dx.doi.org/10.1016/j.nbd.2020.104944DOI Listing

The effect of glaucoma treatment using high-intensity focused ultrasound on total and corneal astigmatism: a prospective multicentre study.

Acta Ophthalmol 2020 May 18. Epub 2020 May 18.

Department of Ophthalmology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

Purpose: Ultrasound cycloplasty (UCP) acts through the selective coagulation of the ciliary body using high-intensity focused ultrasound (HIFU) technology. The aim of this study was to investigate whether the application of ultrasound beams targeting the ciliary body using an external probe influences astigmatism.

Methods: Multicentre, prospective, single-arm, open-label study in adult patients with primary open-angle glaucoma and moderately uncontrolled intraocular pressure (IOP) under glaucoma medication. Read More

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http://dx.doi.org/10.1111/aos.14467DOI Listing

Relationship between intraocular pressure and parameters of obesity in ocular hypertension.

Int J Ophthalmol 2020 18;13(5):794-800. Epub 2020 May 18.

Department of Ophthalmology, Pusan National University College of Medicine and Medical Research Institute of Pusan National University Hospital, Busan 49241, Korea.

Aim: To evaluate the correlation between intraocular pressure (IOP) and various obesity-related health factors in patients with ocular hypertension in Korea.

Methods: A total of 40 850 subjects underwent age, sex, body weight, and height assessments and automated multiphasic tests, including non-contact tonometry, automated perimetry, fundus photography, systolic/diastolic blood pressure measurement, and evaluation of obesity-related health parameters such as obesity index, body mass index (BMI), a body shape index (ABSI), and waist-to-height ratio (WtHR). Subjects were divided into ocular hypertension group and normal IOP group according to IOP after matching of age and sex. Read More

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http://dx.doi.org/10.18240/ijo.2020.05.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201358PMC

Optical coherence tomography angiography of the peripapillary region and macula in normal, primary open angle glaucoma, pseudoexfoliation glaucoma and ocular hypertension eyes.

Int J Ophthalmol 2020 18;13(5):744-754. Epub 2020 May 18.

Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara 06620, Turkey.

Aim: To evaluate and compare the peripapillary and retinal vasculature changes in primary open angle glaucoma (POAG), pseudoexfoliation glaucoma (PXG), ocular hypertension (OHT) and normal eyes using optical coherence tomography angiography (OCTA).

Methods: A total of 114 POAG, PXG and OHT eyes of 60 patients and 46 eyes of 23 healthy control participants with good quality OCTA images were included. The PXG, POAG, OHT, and control groups (aged 68. Read More

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http://dx.doi.org/10.18240/ijo.2020.05.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201354PMC

Intraocular pressure increases during dynamic resistance training exercises according to the exercise phase in healthy young adults.

Graefes Arch Clin Exp Ophthalmol 2020 May 13. Epub 2020 May 13.

Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Purpose: To determine the intraocular pressure (IOP) changes caused by the execution of lower body and upper body resistance training exercises leading to muscular failure depending on the exercise phase (concentric vs. eccentric). We also assessed the influence of the exercise type (back squat vs. Read More

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http://dx.doi.org/10.1007/s00417-020-04736-2DOI Listing

Visual Field Outcomes from the Multicenter, Randomized Controlled Laser in Glaucoma and Ocular Hypertension Trial.

Ophthalmology 2020 Apr 3. Epub 2020 Apr 3.

NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; Institute of Ophthalmology, University College London, United Kingdom.

Purpose: To compare visual field outcomes of ocular hypertensive and glaucoma patients treated first with medical therapy with those treated first with selective laser trabeculoplasty (SLT).

Design: Secondary analysis of patients from the Laser in Glaucoma and Ocular Hypertension study, a multicenter randomized controlled trial.

Participants: Three hundred forty-four patients (588 eyes) treated first with medical therapy and 344 patients (590 eyes) treated first with SLT. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.03.029DOI Listing

Sensitized heat shock protein 27 induces retinal ganglion cells apoptosis in rat glaucoma model.

Int J Ophthalmol 2020 18;13(4):525-534. Epub 2020 Apr 18.

Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China.

Aim: To investigate the relationships between the changes of heat shock protein 27 antibody (anti-HSP27) in serum/cerebrospinal fluid (CSF), intraocular pressure (IOP), retinal ganglion cell (RGC) apoptosis in a rat glaucoma model and disclose the underlying pathogenesis of glaucoma.

Methods: A total of 115 Wistar rats were randomly divided into 4 groups. Group 1 was the ocular hypertension group by condensing 3 episcleral & limbal veins or episcleral area of right eye (HP group, =25) and sham operation group with conjunctiva incision without coagulation (=25). Read More

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http://dx.doi.org/10.18240/ijo.2020.04.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137695PMC
April 2020
0.500 Impact Factor

Predictors of Success in Selective Laser Trabeculoplasty: Data from the Lausanne Laser Trabeculoplasty Registry.

J Glaucoma 2020 May 8. Epub 2020 May 8.

Glaucoma Research Center, Montchoisi Clinic, Swiss Vision Network, Lausanne, Switzerland.

Purpose: To determine the factors associated with the outcomes of selective laser trabeculoplasty (SLT).

Methods: This was a database analysis (Lausanne Laser Trabeculoplasty Registry) of patients who had SLT between 2015 and 2017. Exclusion criteria were age below 40 years and diagnosis other than ocular hypertension and open-angle glaucoma. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001534DOI Listing

A novel rat model of ocular hypertension by a single intracameral injection of cross-linked hyaluronic acid hydrogel (Healaflow ).

Basic Clin Pharmacol Toxicol 2020 May 7. Epub 2020 May 7.

Department of ophthalmology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China.

Purpose: To create a novel animal model of ocular hypertension via the intracameral injection of Healaflow.

Methods: Unilateral chronic ocular hypertension model of rats was created by the intracameral injection of 3 μl Healaflow. The IOP of subjects was monitored. Read More

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http://dx.doi.org/10.1111/bcpt.13430DOI Listing

scAAV2-Mediated C3 Transferase Gene Therapy in a Rat Model with Retinal Ischemia/Reperfusion Injuries.

Mol Ther Methods Clin Dev 2020 Jun 25;17:894-903. Epub 2020 Apr 25.

Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, School of Optometry, Shenzhen University, Shenzhen 518000, China.

Glaucoma is characterized by retinal ganglion cell (RGC) death and axonal loss. Therefore, neuroprotection is important in treating glaucoma. In this study, we explored whether exoenzyme C3 transferase (C3)-based gene therapy could protect retinas in an ischemia/reperfusion (I/R) injury rat model. Read More

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http://dx.doi.org/10.1016/j.omtm.2020.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200613PMC

Intravitreal Injections in Arc Sterile Setting: Safety Profile after More Than 10,000 Treatments.

J Ophthalmol 2020 15;2020:3680406. Epub 2020 Apr 15.

Eye Clinic, Azienda Ospedaliero-Universitaria Policlinico, University of Bari, Bari, Italy.

Purpose: To report the occurrence of endophthalmitis and other complications after intravitreal injections (IVIs) in the Arc Sterile setting.

Methods: A retrospective study that enrolled all patients who underwent IVIs between November 2017 and March 2019, collecting data about the patient's gender and age, type of injected drug, diagnosis, other ocular pathologies, physician and possible occurrence of endophthalmitis, or other complications.

Results: Ten thousand and eighty-three IVIs were performed during the study period, involving 2014 eyes of 1,670 patients with an average age of 71. Read More

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http://dx.doi.org/10.1155/2020/3680406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180985PMC

Henle fibre layer haemorrhage: clinical features and pathogenesis.

Br J Ophthalmol 2020 May 6. Epub 2020 May 6.

Retina Department, Vitreous Retina Macula Consultants of New York, New York, New York, USA.

Background: To describe the clinical presentation and characteristic imaging features of deep retinal haemorrhages primarily located in the Henle fibre layer (HFL) of the macula. The spectrum of aetiologies and a comprehensive theory of pathogenesis are presented.

Methods: This is a retrospective, multicentre case series evaluating eyes with retinal haemorrhage in HFL. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315443DOI Listing

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

Authors:
Lisa de Las Fuentes Yun Ju Sung Raymond Noordam Thomas Winkler Mary F Feitosa Karen Schwander Amy R Bentley Michael R Brown Xiuqing Guo Alisa Manning Daniel I Chasman Hugues Aschard Traci M Bartz Lawrence F Bielak Archie Campbell Ching-Yu Cheng Rajkumar Dorajoo Fernando P Hartwig A R V R Horimoto Changwei Li Ruifang Li-Gao Yongmei Liu Jonathan Marten Solomon K Musani Ioanna Ntalla Tuomo Rankinen Melissa Richard Xueling Sim Albert V Smith Salman M Tajuddin Bamidele O Tayo Dina Vojinovic Helen R Warren Deng Xuan Maris Alver Mathilde Boissel Jin-Fang Chai Xu Chen Kaare Christensen Jasmin Divers Evangelos Evangelou Chuan Gao Giorgia Girotto Sarah E Harris Meian He Fang-Chi Hsu Brigitte Kühnel Federica Laguzzi Xiaoyin Li Leo-Pekka Lyytikäinen Ilja M Nolte Alaitz Poveda Rainer Rauramaa Muhammad Riaz Rico Rueedi Xiao-Ou Shu Harold Snieder Tamar Sofer Fumihiko Takeuchi Niek Verweij Erin B Ware Stefan Weiss Lisa R Yanek Najaf Amin Dan E Arking Donna K Arnett Sven Bergmann Eric Boerwinkle Jennifer A Brody Ulrich Broeckel Marco Brumat Gregory Burke Claudia P Cabrera Mickaël Canouil Miao Li Chee Yii-Der Ida Chen Massimiliano Cocca John Connell H Janaka de Silva Paul S de Vries Gudny Eiriksdottir Jessica D Faul Virginia Fisher Terrence Forrester Ervin F Fox Yechiel Friedlander He Gao Bruna Gigante Franco Giulianini Chi Charles Gu Dongfeng Gu Tamara B Harris Jiang He Sami Heikkinen Chew-Kiat Heng Steven Hunt M Arfan Ikram Marguerite R Irvin Mika Kähönen Maryam Kavousi Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Pirjo Komulainen Aldi T Kraja J E Krieger Carl D Langefeld Yize Li Jingjing Liang David C M Liewald Ching-Ti Liu Jianjun Liu Kurt K Lohman Reedik Mägi Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Dennis O Mook-Kanamori Mike A Nalls Christopher P Nelson Jill M Norris Jeff O'Connell Adesola Ogunniyi Sandosh Padmanabhan Nicholette D Palmer Nancy L Pedersen Thomas Perls Annette Peters Astrid Petersmann Patricia A Peyser Ozren Polasek David J Porteous Leslie J Raffel Treva K Rice Jerome I Rotter Igor Rudan Oscar-Leonel Rueda-Ochoa Charumathi Sabanayagam Babatunde L Salako Pamela J Schreiner James M Shikany Stephen S Sidney Mario Sims Colleen M Sitlani Jennifer A Smith John M Starr Konstantin Strauch Morris A Swertz Alexander Teumer Yih Chung Tham André G Uitterlinden Dhananjay Vaidya M Yldau van der Ende Melanie Waldenberger Lihua Wang Ya-Xing Wang Wen-Bin Wei David R Weir Wanqing Wen Jie Yao Bing Yu Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Donald W Bowden Ian J Deary Marcus Dörr Tõnu Esko Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Jost Bruno Jonas Candace M Kammerer Norihiro Kato Timo A Lakka Karin Leander Terho Lehtimäki Patrik K E Magnusson Pedro Marques-Vidal Brenda W J H Penninx Nilesh J Samani Pim van der Harst Lynne E Wagenknecht Tangchun Wu Wei Zheng Xiaofeng Zhu Claude Bouchard Richard S Cooper Adolfo Correa Michele K Evans Vilmundur Gudnason Caroline Hayward Bernardo L Horta Tanika N Kelly Stephen B Kritchevsky Daniel Levy Walter R Palmas A C Pereira Michael M Province Bruce M Psaty Paul M Ridker Charles N Rotimi E Shyong Tai Rob M van Dam Cornelia M van Duijn Tien Yin Wong Kenneth Rice W James Gauderman Alanna C Morrison Kari E North Sharon L R Kardia Mark J Caulfield Paul Elliott Patricia B Munroe Paul W Franks Dabeeru C Rao Myriam Fornage

Mol Psychiatry 2020 May 5. Epub 2020 May 5.

Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 70808, USA.

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Read More

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http://dx.doi.org/10.1038/s41380-020-0719-3DOI Listing
May 2020
14.496 Impact Factor

Prioritizing outcome preferences in patients with ocular hypertension and open-angle glaucoma using best-worst scaling.

Ophthalmol Glaucoma 2019 Nov-Dec;2(6):367-373. Epub 2019 Sep 3.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Purpose: To quantify patients' preferences for glaucoma outcomes and use this information to prioritize outcomes that are important to patients.

Design: A cross-sectional study using best-worst scaling object case (BWS).

Participants: Two hundred seventy-four participants newly diagnosed with ocular hypertension or mild to moderate open angle glaucoma from three private practices and one academic medical center in the United States. Read More

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http://dx.doi.org/10.1016/j.ogla.2019.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192342PMC
September 2019

Long-Term Outcomes of Allogeneic Ocular Surface Reconstruction: Keratolimbal Allograft (KLAL) Followed by Penetrating Keratoplasty (PK).

J Ophthalmol 2020 14;2020:5189179. Epub 2020 Apr 14.

Department of Ophthalmology with Pediatric Unit, St Barbara 5th Regional Hospital, Trauma Centre, Medykow Square 1, 41200 Sosnowiec, Poland.

Purpose: Long-term results of the patients with total LSCD, who had undergone keratolimbal allograft (KLAL) for limbal reconstruction followed by penetrating keratoplasty (PK).

Methods: The study analyzes surgical treatment of 43 eyes with severe ocular surface disorders. All subjects underwent KLAL to achieve suitable conditions for consecutive PK. Read More

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http://dx.doi.org/10.1155/2020/5189179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178497PMC

Optimizing DME Treatment With Decreased Injection Frequency Using Long-Term Steroid Implants.

Ophthalmic Surg Lasers Imaging Retina 2020 Apr;51(4):S22-S29

Background And Objective: Anti-vascular endothelial growth factor (VEGF) agents are the first-line treatment for diabetic macular edema (DME) based on randomized, control trials from the early 2000s. However, the efficacy of anti-VEGF is limited in clinical practice because its monthly injection schedule is logistically challenging for most working-age patients.

Patients And Methods: Recent large-scale, randomized, control trials have demonstrated that intravitreal corticosteroid implants provide efficacious long-term treatment for DME. Read More

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http://dx.doi.org/10.3928/23258160-20200401-03DOI Listing

Ocular Hypertension Following Intravitreal Injection of 0.7mg Dexamethasone Implant versus 2mg Triamcinolone.

Semin Ophthalmol 2020 Feb 28;35(2):141-146. Epub 2020 Apr 28.

Mid Atlantic Retina, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

: To compare the incidence and outcomes of ocular hypertension (OHT) after intravitreal injection of 0.7 mg dexamethasone (DEX) and 2 mg triamcinolone acetonide (IVT).: In a single-center, retrospective comparative case series, all patients with at least 3 months follow-up receiving 2 mg IVT 3/1/2012 - 3/1/2017 or 0. Read More

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http://dx.doi.org/10.1080/08820538.2020.1758161DOI Listing
February 2020

Nightly Hypoxia Does Not Seem to Lead to Otolith Dysfunction in Patients With Obstructive Sleep Apnea.

Ear Nose Throat J 2020 Apr 27:145561320922126. Epub 2020 Apr 27.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany.

Objectives: Obstructive sleep apnea (OSA) is a common sleep disorder, which is associated with recurrent oxygen desaturation during sleep. It has already been shown that nocturnal hypoxia may lead to cochlear dysfunction in patients with OSA. Less is known whether hypoxia during sleep also impacts vestibular function in those patients. Read More

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http://dx.doi.org/10.1177/0145561320922126DOI Listing

Postoperative treatment compliance rate and complications with two different protocols after pterygium excision and conjunctival autografting.

Eur J Ophthalmol 2020 Apr 27:1120672120917335. Epub 2020 Apr 27.

Ophthalmology Service, Institut Clinic d'Oftalmologia (ICOF), Hospital Clinic de Barcelona, Barcelona, Spain.

Aim: To evaluate compliance rate to pterygium postoperative treatment with two different protocols.

Methods: Review of clinical data of patients submitted to pterygium excision and conjunctival autografting in a single centre (and a single surgeon) in Barcelona between March 2014 and December 2017. Initial postoperative protocol (protocol 1) consisted of 4 months of topical steroids in a tapering fashion. Read More

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http://dx.doi.org/10.1177/1120672120917335DOI Listing