Am J Dermatopathol 2021 Feb 16. Epub 2021 Feb 16.
Department of Dermatology, Chelsea and Westminster Hospital, London, United Kingdom; Department of Histopathology, Royal Hallamshire Hospital, Sheffield, United Kingdom; Biomedical Imaging Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; Department of Plastic and Reconstructive Surgery, Chelsea and Westminster Hospital, London, United Kingdom; and Department of Dermatopathology, St George's University Hospital, London, United Kingdom.
Abstract: A case of localized argyria in a 36-year-old female jeweler is described who presented with 2 discrete and asymptomatic bluish-black pigmented macules on the pulp of her left middle finger. A skin biopsy from both lesions demonstrated deposition of brown/black pigmented granules along the basement membrane zone of eccrine glands, blood vessels, nerves, and the dermo-epidermal junction fully in keeping with silver deposition. In addition, there was yellow-brown deposition seen within the interstitial dermis mimicking an early form of ochronosis, so called "pseudo-ochronosis. Read More