28,196 results match your criteria Obstructive Sleep Apnea-Hypopnea Syndrome


The Clinical Impact of Systematic Screening for Obstructive Sleep Apnea in a Type 2 Diabetes Population-Adherence to the Screening-Diagnostic Process and the Acceptance and Adherence to the CPAP Therapy Compared to Regular Sleep Clinic Patients.

Front Endocrinol (Lausanne) 2018 29;9:714. Epub 2018 Nov 29.

Second Internal Medicine Department, Vinohrady Teaching Hospital, Prague, Czechia.

Obstructive sleep apnea (OSA) is a common disorder in Type 2 diabetes (T2D) patients further increasing their already high cardiovascular risk. As T2D patients typically not report OSA symptoms, systematic screening for OSA in this population is warranted. We aimed to determine the readiness of T2D patients to undergo screening and to compare their adherence to continuous positive airway pressure (CPAP) therapy with "regular" sleep clinic patients who typically seek medical advice on their own initiative. Read More

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http://dx.doi.org/10.3389/fendo.2018.00714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282364PMC
November 2018

No Effect of a Self-Help Book for Insomnia in Patients With Obstructive Sleep Apnea and Comorbid Chronic Insomnia - A Randomized Controlled Trial.

Front Psychol 2018 29;9:2413. Epub 2018 Nov 29.

Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway.

To compare the effects of a self-help book for insomnia to that of sleep hygiene advice in a randomized controlled trial with follow-up after about 3 months among patients who were diagnosed with obstructive sleep apnea (OSA) and comorbid chronic insomnia, and who were concurrently initiating treatment with continuous positive airway pressure (CPAP). In all, 164 patients were included. OSA was diagnosed and categorized based on a standard respiratory polygraphic sleep study using a type 3 portable monitor. Read More

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http://dx.doi.org/10.3389/fpsyg.2018.02413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281758PMC
November 2018

Use of the Clinical Global Impression scale in sleep apnea patients - Results from the ESADA database.

Sleep Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Sleep Medicine, Sahlgrenska University Hospital, Sweden; Sahlgrenska Academy, Gothenburg University, Sweden. Electronic address:

Objective/background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA).

Patients/methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Read More

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http://dx.doi.org/10.1016/j.sleep.2018.10.028DOI Listing
November 2018

Related biomarkers of neurocognitive impairment in children with obstructive sleep apnea.

Int J Pediatr Otorhinolaryngol 2019 Jan 12;116:38-42. Epub 2018 Oct 12.

Department of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157, Xiwu Road, Xi'an, 710004, Shaanxi, China. Electronic address:

Objectives: Different experiment approaches have demonstrated that children with obstructive sleep apnea (OSA) exhibit neurocognitive and behavioral deficits. This review summarized the potential biomarkers of OSA-associated neurocognitive impairment in children.

Methods: A scoping review of studies on children with OSA that evaluated the potential value of different markers in identifying neurocognitive impairment was undertaken. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.10.015DOI Listing
January 2019

Clinical characteristics of obstructive sleep apnea versus infectious adenotonsillar hyperplasia in children.

Int J Pediatr Otorhinolaryngol 2019 Jan 3;116:177-180. Epub 2018 Nov 3.

University of Auckland, Department of Surgery, PO Box 99743, Newmarket, Auckland, 1149, New Zealand.

Introduction: Children who undergo adenotonsillectomy have a range of symptoms. Some present with infective symptoms, others with obstructive symptoms, and many with a combination of both. The most common surgical indication has changed over the past several decades from infective symptoms to obstructive symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183056
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http://dx.doi.org/10.1016/j.ijporl.2018.11.004DOI Listing
January 2019
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Association between REM sleep and obstructive sleep apnea in obese and overweight adolescents.

Sleep Breath 2018 Dec 15. Epub 2018 Dec 15.

Children's Hospital Los Angeles, 4650 Sunset Blvd., #83, Los Angeles, CA, USA.

Purpose: Overweight and obese children have demonstrated reduced rapid eye movement (REM) sleep, affecting energy balance regulation and predisposition to weight gain. Obstructive sleep apnea (OSA) is a known cause of decreased REM sleep. The purpose of this study is to examine the association between the percentage of REM sleep, BMI z-score, and OSA severity in overweight and obese adolescents. Read More

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http://dx.doi.org/10.1007/s11325-018-1768-6DOI Listing
December 2018

The relationship between obstructive sleep apnea and insomnia: a population-based cross-sectional polysomnographic study.

Sleep Med 2018 Nov 17;54:126-133. Epub 2018 Nov 17.

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway; Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, N-7006 Trondheim, Norway.

Background: The relationship between insomnia and objectively measured obstructive sleep apnea (OSA) severity has not previously been investigated in both genders in the general population. The main aim of this population-based polysomnography (PSG) study was to evaluate the cross-sectional association between severity of OSA and DSM-V insomnia and insomnia severity.

Methods: A random sample of 1200 participants in the third Nord-Trøndelag Health Study (HUNT3) was invited and 213 (18%) aged between 21 and 82 years underwent an ambulatory PSG, a semi-structured interview, and a sleep-specific questionnaire. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.10.026DOI Listing
November 2018

Spectral analysis of peri-pharyngeal muscles' EMG in patients with OSA and healthy subject.

Respir Physiol Neurobiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine, Bnai-Zion Medical Centre, Haifa, Israel; Rappaport School of Medicine, Technion Institute of Technology, Haifa, Israel. Electronic address:

Introduction: In addition to dyscoordination of upper airway dilator muscles activity, sleep may also alter the pattern of intra-muscular activation of single motor units (SMUs). Such changes should be identifiable by a state dependent change in EMG power spectrum, i.e. Read More

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http://dx.doi.org/10.1016/j.resp.2018.12.002DOI Listing
December 2018
1 Read

Risk factors for admission after shoulder arthroscopy.

J Shoulder Elbow Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Orthopaedic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background: Shoulder arthroscopy is a common orthopedic procedure typically performed on an outpatient basis. Occasionally, patients require an unplanned hospital admission. An understanding of the incidence and risk factors for admission after shoulder arthroscopy may assist surgeons in determining which patients may be susceptible to unplanned admission after surgery. Read More

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http://dx.doi.org/10.1016/j.jse.2018.09.031DOI Listing
December 2018

Computational fluid dynamics analysis of H-uvulopalatopharyngoplasty in obstructive sleep apnea syndrome.

Am J Otolaryngol 2018 Dec 6. Epub 2018 Dec 6.

The Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin University, Changchun, 130000, Jilin Province, China. Electronic address:

Purpose: To explore the impact of H-uvulopalatopharyngoplasty (H-UPPP) in obstructive sleep apnea syndrome (OSAS) and gain insights into the potential mechanism underlying improvement by H-UPPP.

Methods: In a cohort of 11 OSAS patients, computational fluid dynamics (CFD) models of the upper airway were obtained using commercial software from computed tomography (CT) datasets before and after H-UPPP. Morphological and numerical parameters were respectively computed and compared during the peak tidal inspiratory flow. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.12.001DOI Listing
December 2018

Protective effects of REM sleep without atonia against obstructive sleep apnea in patients with idiopathic REM sleep behavior disorder.

Sleep Med 2018 Nov 19;54:116-120. Epub 2018 Nov 19.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: This study investigated the protective effect of rapid eye movement (REM) sleep without atonia against obstructive sleep apnea (OSA) in patients with idiopathic REM sleep behavior disorder (RBD).

Methods: In this case-control study, patients with idiopathic RBD and OSA (RBD-OSA) were consecutively enrolled and OSA controls without RBD were matched for age, sex, and apnea-hypopnea index (AHI). Clinical and polysomnographic characteristics were compared between RBD-OSA patients and OSA controls. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.10.032DOI Listing
November 2018
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Severity of obstructive sleep apnea and extension of coronary artery disease.

Sleep Breath 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Purpose: Obstructive sleep apnea (OSA) is highly prevalent among patients with coronary artery disease (CAD). The relationship between the severity of OSA and the severity of CAD has not been entirely established. The objective was to explore the type of correlation existent between the apnea-hypopnea index and the Gensini score, which provides granularity in terms of CAD extension and severity, in search of a dose-response relationship. Read More

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http://link.springer.com/10.1007/s11325-018-1769-5
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http://dx.doi.org/10.1007/s11325-018-1769-5DOI Listing
December 2018
2 Reads

Elevated plasma total tau and interleukin-6 concentrations in patients with obstructive sleep apnea with special reference to neuronal damage.

Authors:
Tomoyuki Kawada

Sleep Med 2018 Nov 23. Epub 2018 Nov 23.

Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo 113-8602, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2018.11.002DOI Listing
November 2018

[Uvuplopalatal flap in OSAHS patients with anteriorand posterior pharyngeal plane stenosis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1817-1820

Department of Otorhinolaryngology, Affiliated Hospital of Yanbian University College of Medicine, Yanji, 133000, China.

Observation of the effect of uvuplopalatal flap for OSAHS patients with anterior and posterior pharyngeal stenosis. Fifty-six patients with OSAHS who were mainly anterior posterior stenosis in the velopharyngeal plane were selected. Patients with suspending uvuplopalatal flap were used as observation group (30 cases). Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.23.012DOI Listing
December 2018

[Effect of butylphthalide on oxidative stress and cognitive function in old obstructive sleep apnea hypopnea syndrome patients].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1422-1425

Department of Respiration of North China University of Science and Technology Affiliated Hospital, 063000, China.

To explore the effect of butylphthalide on oxidative stress and cognitive function in old obstructive sleep apnea hypopnea syndrome (OSAHS)patients.A total of 90 old OSAHS patients with cognitive impairment were choosed with Polysomnography(PSG). By random number table method OSAHS patients were randomly divided into non-invasive ventilator group (=30), butylphthalide with non-invasive ventilator group(=30) and treatment group of butylphthalide(=30). Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.18.014DOI Listing
September 2018
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[Effects of sleep body posture on subjective sleepiness in patients with OSAHS].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1418-1421

Department of Otorhinolaryngology,the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University,Huaian, 223300, China.

To observe the effects of sleep body posture on subjective sleepiness in patients with OSAHS. We assessed the sleeping body position, the sleep structure, position specific AHI and the Epworth Sleepiness Scale (ESS) in a total of 90 patients with OSAHS. The patients were grouped according to AHI: mild OSAHS (5≤AHI<15), moderate (15≤AHI<30) and severe (AHI≥30). Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.18.013DOI Listing
September 2018

[Cognitive status and its relationship with serum neuropeptide Y in patients with obstructive sleep apnea hypopnea syndrome].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1414-1417

Department of Respiratory Medicine, Huainan First People's Hospital.

To analyze the correlation between cognitive function and serum NPY levels in OSAHS patients, and to explore biomarkers for evaluating cognitive function in adult patients with OSAHS. To verify the validity of MoCA in evaluating cognitive function in OSAHS patients.72 patients with OSAHS and 16 healthy controls were included. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.18.012DOI Listing
September 2018
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[Relationship between upper airway volume and polysomnography parameters of patients with obstructive sleep apnea hypopnea syndrome].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1409-1413

Department of Otolaryngology, the University of Hong Kong-Shenzhen Hospital, Shenzhen, 518000, China.

To study the relationship among upper airway volume of naso-pharyngeal, yelo-pharyngeal,glosso-pharyngeal, hypo-pharyngeal area which measured by spiral computed tomography three-dimensional reconstruction technique, apnea hypopnea indexes, and the lowest oxygen saturation in patients with OSAHS.①fifty-one patients with OSAHS were received polysomnography, and then were divided into groups by the AHI,LSaO₂ values. ②To measure upper airway volume at normal breath and Müller maneuver state using spiral computed tomography three-dimensional reconstruction technique of CT measurement, and to calculate volume change rate and observe the upper airway compliance. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.18.011DOI Listing
September 2018

[The application of cineMRI in evaluation of upper airway obstruction levels in complicated pediatric OSAS].

Authors:
S He R D Zhang J Chen

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1886-1889

Department of Otolaryngology, Shanghai Children's Medical Center Affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.

The aim of this study is to explore the role of cineMRI in the localization of upper airway obstruction in complicated pediatric OSAS. Eleven persistent OSAS and 11 complex OSAS patients underwent cineMRI. Each patient was imaged midline sagittal and axial magnetic resonance cine image. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.24.009DOI Listing
December 2018

Validation of CollaboRATE and SURE - two short questionnaires to measure shared decision making during CPAP initiation.

J Sleep Res 2018 Dec 13:e12808. Epub 2018 Dec 13.

Department of Clinical Neurophysiology, Linköping University Hospital, Linköping, Sweden.

Adherence to continuous positive airway pressure (CPAP) treatment tends to be low. Brief validated instruments focusing on shared decision making have not been used in a CPAP context. The aim was to investigate factorial structure, categorical functioning of the response scale and differential item functioning across sub-populations of the CollaboRATE and Sure questionnaires among patients with obstructive sleep apnea (OSA) before CPAP treatment is initiated. Read More

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http://dx.doi.org/10.1111/jsr.12808DOI Listing
December 2018

Hypoglossal nerve stimulation in three adults with down syndrome and severe obstructive sleep apnea.

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York, New York.

We present three adults with Down syndrome and obstructive sleep apnea (OSA) treated with hypoglossal nerve stimulation. The average age of these three males was 37.3 years. Read More

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http://dx.doi.org/10.1002/lary.27723DOI Listing
December 2018

Is obstructive sleep apnea syndrome related to nocturia?

Low Urin Tract Symptoms 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey.

Objective: The aim of this study was to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH).

Methods: This multicenter study was performed on 122 male patients with dyspnea and/or sleep disorder. Patient characteristics were recorded. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/luts.12250
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http://dx.doi.org/10.1111/luts.12250DOI Listing
December 2018
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The role of polysomnography in decannulation of children with brain and spinal cord injuries.

Pediatr Pulmonol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatric Rehabilitation Medicine, Kennedy Krieger Institute, Baltimore, Maryland.

Objective: The objective of this retrospective review was to determine the utility of polysomnography (PSG) in influencing the decision to decannulate pediatric patients with brain and spinal cord injuries in an inpatient rehabilitation hospital setting.

Methods: Between 2010 and 2016, data were collected on pediatric patients with brain and/or spinal cord injuries who had PSG performed with the goal of decannulation. Patients underwent a decannulation protocol involving toleration of continuous tracheostomy capping and bedside tracheoscopy by otolaryngology. Read More

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http://dx.doi.org/10.1002/ppul.24208DOI Listing
December 2018

Assessment of right atrium dysfunction in patients with obstructive sleep apnea syndrome using velocity vector imaging.

Cardiovasc Ultrasound 2018 Dec 13;16(1):32. Epub 2018 Dec 13.

Department of Echocardiography, Qingdao University Affiliated Hospital, No. 16 Jiangsu Road, Qingdao, 266001, China.

Background And Objectives: This study aimed to assess the changes of RA function in patients with obstructive sleep apnea syndrome (OSAS) using velocity vector imaging (VVI) and to evaluate the application of VVI technology.

Methods: According to the apnea-hypopnea index (AHI), 71 patients with OSAS were divided into three groups: mild, moderate, and severe. A total of 30 cases of healthy subjects were enrolled as the control group. Read More

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http://dx.doi.org/10.1186/s12947-018-0150-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292122PMC
December 2018

Measurement of fractional exhaled nitric oxide and nasal nitric oxide in male patients with obstructive sleep apnea.

Sleep Breath 2018 Dec 12. Epub 2018 Dec 12.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Objective: Airway inflammation plays an important role in obstructive sleep apnea (OSA); exhaled nitric oxide is regarded as a noninvasive marker of airway inflammation. The aim of this study was to evaluate fractional exhaled nitric oxide (FeNO) and nasal nitric oxide (nNO) in patients with OSA.

Methods: Seventy-five patients with OSA and 30 health controls were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s11325-018-1760-1DOI Listing
December 2018

Resistant and refractory hypertension: two sides of the same disease?

J Bras Nefrol 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Medicina, Faculdade de Ciências Médicas e da Saúde, Pontifícia Universidade Católica de São Paulo, Rio de Janeiro, RJ, Brasil.

Refractory hypertension (RfH) is an extreme phenotype of resistant hypertension (RH), being considered an uncontrolled blood pressure besides the use of 5 or more antihypertensive medications, including a long-acting thiazide diuretic and a mineralocorticoid antagonist. RH is common, with 10-20% of the general hypertensives, and its associated with renin angiotensin aldosterone system hyperactivity and excess fluid retention. RfH comprises 5-8% of the RH and seems to be influenced by increased sympathetic activity. Read More

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http://dx.doi.org/10.1590/2175-8239-jbn-2018-0108DOI Listing
December 2018

Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea.

Front Endocrinol (Lausanne) 2018 13;9:651. Epub 2018 Nov 13.

Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Kuwait City, Kuwait.

Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health complications, such as hypertension, cardiovascular disease, and Type 2 diabetes. Angiopoietin-like protein (ANGPTL)-4 and ANGPTL8 (betatrophin) have been suggested to play a role in the development of these diseases through their role in regulating the metabolism of plasma lipid molecules. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00651
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http://dx.doi.org/10.3389/fendo.2018.00651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262344PMC
November 2018
1 Read

A Novel Non-invasive Approach for Measuring Upper Airway Collapsibility in Mice.

Front Neurol 2018 20;9:985. Epub 2018 Nov 20.

Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.

Invasive procedures were previously developed for measuring pharyngeal collapsibility in rodents during expiration, when declining neuromuscular activity makes the airway unstable. We developed a non-invasive approach for streamlining collapsibility measurements by characterizing responses in physiologic markers of dynamic expiratory airflow obstruction to negative nasal pressure challenges. Anesthetized mice were instrumented to monitor upper airway pressure-flow relationships with head-out plethysmography while nasal pressure was ramped down from ~ +5 to -20 cm HO over several breaths. Read More

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http://dx.doi.org/10.3389/fneur.2018.00985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256100PMC
November 2018

Feature relevance in physiological networks for classification of obstructive sleep apnea.

Physiol Meas 2018 Nov 14. Epub 2018 Nov 14.

Center for Biomedical Image and Information Processing, University of Applied Sciences Berlin, Berlin, GERMANY.

Objective: Physiological networks (PN) model couplings between organs in a high- dimensional parameter space. Machine learning methods, in particular artifical neural networks (ANNs), are powerful on high-dimensional classification tasks. However, lack of interpretability of the resulting models has been a drawback in research. Read More

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http://dx.doi.org/10.1088/1361-6579/aaf0c9DOI Listing
November 2018

Psychometric properties of the Ethos Brief Index (EBI) using factorial structure and Rasch Analysis among patients with obstructive sleep apnea before and after CPAP treatment is initiated.

Sleep Breath 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Neurophysiology, Linköping University Hospital, S-581 85, Linköping, Sweden.

Background: Continuous positive airway treatment (CPAP) is the recommended treatment for patients with obstructive sleep apnea (OSA). Outcome measures often focus on clinical and/or self-rated variables related to the medical condition. However, a brief validated instrument focusing on the whole life situation (i. Read More

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http://dx.doi.org/10.1007/s11325-018-1762-zDOI Listing
December 2018

A false alarm of narcolepsy: obstructive sleep apnea masquerading as narcolepsy and depression.

Sleep Breath 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Purpose: We report a case with symptoms and signs of obstructive sleep apnea (OSA), depression, and narcolepsy. Polysomnographic (PSG) and multiple sleep latency test (MSLT) findings, clinical characteristics, and diagnostic challenges in this case are discussed.

Methods: A 23-year-old single male presented with excessive daytime sleepiness, low mood, lack of energy, and snoring for 3 years. Read More

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http://dx.doi.org/10.1007/s11325-018-1767-7DOI Listing
December 2018

The impact of continuous positive airway pressure treatment on the recurrence of atrial fibrillation post cardioversion: A randomized controlled trial.

Int J Cardiol 2018 Nov 20. Epub 2018 Nov 20.

Department of Cardiovascular Diseases, Rochester, MN, USA.

Background: Observational data suggest that positive airway pressure (PAP) treatment of obstructive sleep apnea (OSA) can reduce the risk of recurrent atrial fibrillation (AF) post-direct current cardioversion (DCCV) or catheter ablation.

Methods: We conducted a study of adult patients with AF and sleep apnea, stratified by age and gender, who underwent successful DCCV to sinus rhythm, and who were randomized to receive PAP or usual care. Those with sleepiness, significant cardiac or respiratory disease were excluded. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.11.100DOI Listing
November 2018

Predictors of CPAP adherence following stroke and transient ischemic attack.

Sleep Med 2018 Oct 24. Epub 2018 Oct 24.

Department of Medicine, Division of Neurology, University of Toronto, Canada; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Canada; L.C. Campbell Cognitive Neurology Research Unit, Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, Toronto, Canada; Sleep Laboratory, Sunnybrook Health Sciences Centre, Toronto, Canada. Electronic address:

Objective: Continuous positive airway pressure (CPAP) has been shown to improve functional, motor and cognitive outcomes in post-stroke obstructive sleep apnea (OSA). However, rates of CPAP adherence are often low and factors impacting CPAP adherence remain under-explored. Our objective was to determine predictors of CPAP adherence in patients who had a stroke or transient ischemic attack (TIA). Read More

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http://dx.doi.org/10.1016/j.sleep.2018.10.009DOI Listing
October 2018

Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.

Purpose: To evaluate the effect of adenoidectomy on the brains of children with obstructive sleep apnea-hypopnea syndrome (OSAS) through observation of the alteration of retinal perfusion by optical coherence tomography angiography (OCTA).

Methods: Sixty-two children with OSAS (124 eyes; 5.94 ± 1. Read More

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http://dx.doi.org/10.1007/s00417-018-04207-9DOI Listing
December 2018

Nasal function and CPAP compliance.

Auris Nasus Larynx 2018 Dec 8. Epub 2018 Dec 8.

Department of Otorhinolaryngology, Toho University Graduate School of Medicine, Japan; Department of Otorhinolaryngology, Toho University Omori Medical Center, Japan. Electronic address:

Objective: Continuous positive airway pressure (CPAP) is the mainstay therapy for patients with obstructive sleep apnea (OSA) however compliance with CPAP is variable. Nasal ailments, such as nasal congestion are frequently mentioned as a cause for CPAP non-compliance, and potentially could be addressed prior to CPAP initiation, however, no specific criteria or recommendations for the evaluation and management of these patients exist. The aim of this retrospective study is to evaluate the effects of nasal anatomic features and disease on adherence to CPAP therapy for patients with OSA and determine the indications for pre-CPAP nasal treatment by using data obtained at clinical examination. Read More

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http://dx.doi.org/10.1016/j.anl.2018.11.006DOI Listing
December 2018

Gene Expression Profiles of Tumor Necrosis Factor-α and Endothelin-1 in Obstructive Sleep Apnea.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):16-23. Epub 2018 Dec 11.

Department of Otolaryngology and Head and Neck Surgery, Wakayama University Hospital, Wakayama, Japan.

Background/aims: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-α and endothelin (EDN)-1 and obstructive sleep apnea (OSA).

Methods: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). Read More

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https://www.karger.com/Article/FullText/490353
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http://dx.doi.org/10.1159/000490353DOI Listing
December 2018
7 Reads

Bariatric Surgery in the Elderly Patient: Safety and Short-time Outcome. A Case Match Analysis.

Obes Surg 2018 Dec 7. Epub 2018 Dec 7.

General Surgery, Mayo Clinic, Jacksonville, FL, USA.

Background: Indications and outcomes of bariatric surgery in the elderly remain controversial. We aimed to evaluate and compare safety and early outcomes of bariatric procedures in this age group.

Study Design: We performed a retrospective case-control study of Mayo Clinic bariatric surgery patients from January 1, 2016, to January 31, 2018. Read More

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http://dx.doi.org/10.1007/s11695-018-03633-2DOI Listing
December 2018
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Expression profile of long non-coding RNAs in rat models of OSA-induced cardiovascular disease: new insight into pathogenesis.

Sleep Breath 2018 Dec 7. Epub 2018 Dec 7.

Department of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, No.20 Chazhong Road, Fuzhou, 350005, Taijiang District, China.

Purpose: Long non-coding RNAs (lncRNAs) are a recently identified class of regulatory molecules involved in the regulation of numerous biological processes, but their functions in a rat model of chronic intermittent hypoxia (CIH) remain largely unknown. Therefore, for further investigation, we aimed to explore lncRNA expression profiles and reveal their potential functional roles in rat models of CIH.

Methods: We used a well-established CIH rat model and conducted lncRNA microarray experiments on the heart samples of rats with CIH and under normoxia control. Read More

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http://dx.doi.org/10.1007/s11325-018-1753-0DOI Listing
December 2018

Tongue Function: An Underrecognized Component in the Treatment of Obstructive Sleep Apnea with Mandibular Repositioning Appliance.

Can Respir J 2018 6;2018:2157974. Epub 2018 Nov 6.

Department of Orthodontics, Case Western Reserve University, Cleveland, USA.

Obstructive sleep apnea (OSA) is a common but still underrecognized disorder. A mandibular repositioning appliance (MRA) is used to treat OSA by advancing the mandible and thereby reducing the collapsibility of the upper airway. It has been found that an MRA increases the volume of the upper airway, especially the velopharyngeal area, in OSA patients. Read More

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http://dx.doi.org/10.1155/2018/2157974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247694PMC
November 2018
1.663 Impact Factor

Bimaxillary Orthognathic Surgery Is Associated With an Increased Risk of Early Complications.

J Craniofac Surg 2018 Dec 10. Epub 2018 Dec 10.

Hansjörg Wyss Department of Plastic Surgery, New York University Langone Health, New York, NY.

Introduction: Orthognathic surgery plays an important role in restoring aesthetic facial contour, correcting dental malocclusion, and the surgical treatment of obstructive sleep apnea. However, the rate of complications following bimaxillary as compared with single-jaw orthognathic surgery remains unclear. The authors therefore sought to evaluate complication rates following bimaxillary as compared with single-jaw orthognathic surgery MATERIALS AND METHODS:: The American College of Surgeons National Surgical Quality Improvement Program database was used to identify comparison groups. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005026DOI Listing
December 2018

Accuracy of the sleep-related breathing disorder scale to diagnose obstructive sleep apnea in children: a meta-analysis.

Sleep Med 2018 Oct 28;54:78-85. Epub 2018 Oct 28.

Department of Anesthesia and Intensive Care, Robert Debre University Hospital, Paris, France; Paris Diderot University, 10 Avenue de Verdun, 75010, Paris, France; DHU PROTECT, INSERM U1141, Robert Debre University Hospital, Paris, France. Electronic address:

Objectives: The main objective of this meta-analysis was to assess the accuracy of the Sleep-Related Breathing Disorder (SRBD) Scale in the diagnosis of obstructive sleep apnea syndrome (OSAS) in children.

Patients/methods: A literature search of studies comparing SRBD to polysomnography for the diagnosis of OSAS in children was performed. Risks of biases were quantified using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.09.027DOI Listing
October 2018

Obstructive events in children with Prader-Willi syndrome occur predominantly during rapid eye movement sleep.

Sleep Med 2018 Oct 28;54:43-47. Epub 2018 Oct 28.

Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece. Electronic address:

Objective: Children with Prader-Willi syndrome (PWS) have a high prevalence of obstructive sleep apnea syndrome (OSAS). In most typically developing children with OSAS, more obstructive apneas and hypopneas occur during rapid eye movement (REM) than during non-REM (NREM) sleep. It was hypothesized that patients with PWS are even more prone to obstructive events in REM sleep than otherwise healthy subjects with OSAS. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.09.026DOI Listing
October 2018

Continuous positive airway pressure for adults with obstructive sleep apnea and cardiovascular disease: a meta-analysis of randomized trials.

Sleep Med 2018 Oct 30;54:28-34. Epub 2018 Oct 30.

Postgraduate Programs in Health Sciences and in Public Health, Respiratory Division, Federal University of Rio Grande, Rio Grande, Brazil. Electronic address:

Background: It remains uncertain whether continuous positive airway pressure (CPAP) therapy would significantly impact hard clinical outcomes in patients with obstructive sleep apnea (OSA). This meta-analysis aimed to assess the effects of CPAP in survival and secondary prevention of major cardiovascular events in patients with OSA and cardiovascular disease (CVD).

Methods: PubMed, Cochrane CENTRAL, LILACS, and SciElo databases (up to January 2018) were searched for randomized trials that compared CPAP with no active treatment in adults with OSA and CVD. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.09.030DOI Listing
October 2018

Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model.

Neuroscience 2018 Dec 7. Epub 2018 Dec 7.

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY, United States; Department of Neuroscience, University of Kentucky, Lexington, KY, United States. Electronic address:

Sleep disturbances are a common early symptom of neurodegenerative diseases, including Alzheimer's disease (AD) and other age-related dementias, and emerging evidence suggests that poor sleep may be an important contributor to development of amyloid pathology. Of the causes of sleep disturbances, it is estimated that 10-20% of adults in the United States have sleep-disordered breathing (SDB) disorder, with obstructive sleep apnea accounting for the majority of the SBD cases. The clinical and epidemiological data clearly support a link between sleep apnea and AD; yet, almost no experimental research is available exploring the mechanisms associated with this correlative link. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.11.040DOI Listing
December 2018

Obstructive sleep apnea as a predictor of reduced heart rate variability.

Sleep Med 2018 Oct 11;54:8-15. Epub 2018 Oct 11.

Department of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Borowska 213, PL 50-556, Wroclaw, Poland.

Purpose: This study aimed to analyze the relationship between the occurrence of obstructive sleep apnea (OSA) and heart rate variability (HRV) in a group of patients with clinical suggestion of OSA.

Methods: 104 patients with clinical suspicion of OSA were qualified to participate in the study (age: 53.15 ± 13. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13899457183023
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http://dx.doi.org/10.1016/j.sleep.2018.09.014DOI Listing
October 2018
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Quantitative analysis of carotid arterial calcification using airway CT in obstructive sleep apnea.

Auris Nasus Larynx 2018 Dec 6. Epub 2018 Dec 6.

Department of Otorhinolaryngology-Head and Neck Surgery, Dong-A University College of Medicine, Busan, Republic of Korea.

Objective: To evaluate the relationship between obstructive sleep apnea (OSA) severity and carotid arterial calcification by quantitative analysis using airway computed tomography (CT).

Methods: This study included a total of 180 consecutive OSA patients aged 45-80years underwent polysomnography and airway CT between March 2014 and October 2016. The subjects were divided into three groups based on the results of the respiratory disturbance index (RDI): mild (RDI 5-14, n=29), moderate (RDI 15-29, n=50), and severe (RDI≥30, n=101). Read More

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http://dx.doi.org/10.1016/j.anl.2018.11.015DOI Listing
December 2018
2 Reads

Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner?

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

Johns Hopkins University, Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States ;

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http://dx.doi.org/10.1164/rccm.201811-2135EDDOI Listing
December 2018
4 Reads

Solriamfetol for Excessive Sleepiness in Obstructive Sleep Apnea (TONES 3): A Randomized Controlled Trial.

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

Case Western Reserve University, Cleveland, Ohio, United States.

Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic options for the treatment of sleepiness in this population are limited. Read More

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http://dx.doi.org/10.1164/rccm.201806-1100OCDOI Listing
December 2018
2 Reads