31,747 results match your criteria Obstructive Sleep Apnea-Hypopnea Syndrome


[Analysis of Snoring in Patients with Obstructive Sleep Apnea (OSA) by Polysomnography and LEOSound].

Pneumologie 2020 Jun 3. Epub 2020 Jun 3.

Klinik für Innere Medizin, SP Pneumologie, Intensiv- und Schlafmedizin, Philipps-Universität, Marburg.

Introduction:  Snoring was monitored in patients with obstructive sleep apnea (OSA) using the LEOSound-Monitor and simultaneously polysomnographic (PSG) recording. In obstructive apneas snoring is normally apparent after apnea termination and the beginning of ventilation. We wanted to know how often obstructive apneas are terminated by ventilation in combination with snoring. Read More

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http://dx.doi.org/10.1055/a-1155-8772DOI Listing

Association of Obstructive Sleep Apnea with Nighttime Blood Pressure in African Americans: the Jackson Heart Study.

Am J Hypertens 2020 Jun 3. Epub 2020 Jun 3.

Brigham and Women's Hospital, Boston, MA.

Background: Obstructive sleep apnea (OSA), nocturnal hypertension, and non-dipping systolic blood pressure (BP) are each highly prevalent among African Americans. However, few data are available on the association between OSA and nighttime BP in this population.

Methods: We examined the association of OSA with nighttime BP among African Americans who completed 24-hour ambulatory BP monitoring at Exam 1 (2000-2004) of the Jackson Heart Study (JHS) and subsequently participated in the JHS Sleep Study (2012-2016). Read More

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http://dx.doi.org/10.1093/ajh/hpaa088DOI Listing

Risk factors for aggressive recurrent respiratory papillomatosis in Chinese juvenile patients.

Acta Otolaryngol 2020 Jun 3:1-6. Epub 2020 Jun 3.

Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Aggressive juvenile-onset recurrent respiratory papillomatosis (JORRP) threatens patient lives if not receives immediate surgical intervene. Even with surgical intervene, complete remission of this disease is not approachable. Therefore, understanding the factors relevant to disease severity and prognosis will do help to the treatment strategy and health management of this disease. Read More

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http://dx.doi.org/10.1080/00016489.2020.1767804DOI Listing

Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups.

Int J Cardiol Heart Vasc 2020 Jun 29;28:100538. Epub 2020 May 29.

Departments of Medicine, University of Illinois at Chicago, USA.

Background: Although traditional risk factors for atrial fibrillation (AF) and its outcomes are established in whites, their role in the pathogenesis of AF across race-ethnicity and both sexes remain unclear. Cohort studies have consistently shown worse AF-related outcomes in these groups. The objective of this study was to determine the role played by race- and sex-specific risk factors in AF outcomes in non-Hispanic blacks (NHBs), Hispanics/Latinos (H/Ls), and non-Hispanic whites (NHWs). Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262442PMC

The correlation between oxygen saturation indices and the standard obstructive sleep apnea severity.

Ann Thorac Med 2020 Apr-Jun;15(2):70-75. Epub 2020 Apr 3.

Somnogen Canada Inc., Toronto, ON, Canada.

Objective: Currently accepted guidelines categorize obstructive sleep apnea (OSA) severity according to the Apnea-Hypopnea Index (AHI). However, it is unclear how to best define OSA severity. The present study sought to evaluate the concurrent validity of the widely accepted AHI by correlating it with various oxygen saturation (SpO) and polysomnographic parameters. Read More

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http://dx.doi.org/10.4103/atm.ATM_215_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259396PMC

Reversibility of microalbuminuria with continuous positive airway pressure treatment in obstructive sleep apnea syndrome.

Int Urol Nephrol 2020 Jun 1. Epub 2020 Jun 1.

Department of Chest Diseases, Istanbul Kartal Dr. Lütfi Kirdar Training and Research Hospital, Istanbul, Turkey.

Introduction: Microalbuminuria is an early marker of kidney damage and an early predictor and risk factor for cardiovascular diseases. We aimed to evaluate the association between albuminuria levels in different severity obstructive sleep apnea syndrome (OSAS) cases and to find out the efficacy of CPAP treatment on microalbuminuria.

Materials And Methods: We conducted a prospective study on subjects who underwent polysomnography. Read More

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http://dx.doi.org/10.1007/s11255-020-02519-6DOI Listing

Long-Term Results of the Mediterranean Diet After Sleeve Gastrectomy.

Obes Surg 2020 Jun 2. Epub 2020 Jun 2.

Department of Medicine, Surgery, and Dentistry, "Scuola Medica Salernitana", University of Salerno, Fisciano, Italy.

Background: To assess dietary habits in a cohort of patients at minimum follow-up of 4 years after sleeve gastrectomy (SG) by comparing their dietary records to the Italian Mediterranean diet (IMD) recommendations.

Methods: We prospectively evaluated in 74 patients who had the SG in 2014 dietary habits by a 7-day food dietary records, weight and micronutrient status, evolution of comorbidities, use of micronutrient supplements, and frequency of physical activity.

Results: The IMD recommendations in terms of daily/weekly portions of fruits, vegetables, and complex carbohydrates were followed by 40. Read More

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http://dx.doi.org/10.1007/s11695-020-04695-xDOI Listing

Cross motor innervation of the hypoglossal nerve-a pilot study of predictors for successful opening of the soft palate.

Sleep Breath 2020 Jun 2. Epub 2020 Jun 2.

Department of Otorhinolaryngology, Head and Neck Surgery University of Freiburg, Freiburg im Breisgau, Germany.

Purpose: Selective hypoglossal nerve stimulation has proven to be a successful treatment option in patients with obstructive sleep apnea. The aim of this pilot study was to investigate if there is a cross-innervation of the hypoglossal nerve in humans and if patients with this phenotype show a different response to hypoglossal nerve stimulation compared to those with ipsilateral-only innervation METHODS: Nineteen patients who previously received a selective hypoglossal nerve stimulation system (Inspire Medical Systems, Golden Valley, USA) were implanted with a nerve integrity system placing electrodes on both sides of the tongue. Tongue motions were recorded one and two months after surgery from transoral and transnasal views. Read More

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http://dx.doi.org/10.1007/s11325-020-02112-2DOI Listing

Voice outcomes for patients undergoing surgery for obstructive sleep apnea: a systematic review and meta-analysis.

Eur Arch Otorhinolaryngol 2020 Jun 2. Epub 2020 Jun 2.

Department of Otolaryngology, Head and Neck Surgery, Gulhane Medical School, Ankara, Turkey.

Purpose: To evaluate the effect of the different surgical techniques used in the treatment of obstructive sleep apnea (OSA) on the postoperative voice and nasalance, and to conduct a meta-analysis through the assessment of postoperative changes.

Methods: Systematic literature review and meta-analysis of published data using the data sources, MEDLINE, Google Scholar, Cochrane, and SAGE. All studies published in English specifying any upper airway surgery for treatment of snoring and/or OSA were included, provided they indicated the pre- and postoperative mean ± standard deviation (SD) values for voice parameters and nasality. Read More

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http://dx.doi.org/10.1007/s00405-020-06101-9DOI Listing

Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals.

Nat Commun 2020 Jun 2;11(1):2769. Epub 2020 Jun 2.

Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.

During obstructive sleep apnea, elevation of CO during apneas contributes to awakening and restoring airway patency. We previously found that glutamatergic neurons in the external lateral parabrachial nucleus (PBel) containing calcitonin gene related peptide (PBel neurons) are critical for causing arousal during hypercapnia. However, others found that genetic deletion of serotonin (5HT) neurons in the brainstem also prevented arousal from hypercapnia. Read More

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http://dx.doi.org/10.1038/s41467-020-16518-9DOI Listing

Obstructive sleep apnea caused by acromegaly: Case report.

Cranio 2020 Jun 2:1-3. Epub 2020 Jun 2.

Department of Oral and Maxillofacial Surgery, Amsterdam UMC and Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam , Amsterdam, The Netherlands.

Background: Acromegaly is an uncommon syndrome caused by growth hormone-producing pituitary adenoma or pituitary gland hypertrophy. Acromegaly is known to be characterized by progressive somatic disfigurement and a wide range of systematic manifestations. This case study describes a rare case of severe obstructive sleep apnea (OSA) caused by acromegaly. Read More

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http://dx.doi.org/10.1080/08869634.2020.1776530DOI Listing

Ghrelin suppresses migration of macrophages via inhibition of ROCK2 under chronic intermittent hypoxia.

J Int Med Res 2020 Jun;48(6):300060520926065

Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, China.

Objectives: Migration of macrophages and atherosclerosis result in various diseases, including coronary heart disease. This study aimed to clarify the roles that ghrelin and Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) play in migration of macrophages under chronic intermittent hypoxia (CIH).

Methods: A rat model of CIH was constructed and changes in ghrelin and ROCK2 protein expression were measured by western blot assay. Read More

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http://dx.doi.org/10.1177/0300060520926065DOI Listing

COVID-19 and obstructive sleep apnea.

J Clin Sleep Med 2020 Jun 2. Epub 2020 Jun 2.

Bahiana's School of Medicine and Public Health, Salvador, Brazil.

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http://dx.doi.org/10.5664/jcsm.8606DOI Listing

Alternations of Blood Pressure Before and After OSA Surgery.

Otolaryngol Head Neck Surg 2020 Jun 2:194599820926137. Epub 2020 Jun 2.

Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung.

Objective: To investigate the changes of blood pressure (BP) on patients with obstructive sleep apnea/hypopnea syndrome (OSA) before and after upper airway surgery.

Design: Case series with chart review.

Setting: Tertiary academic medical center. Read More

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http://dx.doi.org/10.1177/0194599820926137DOI Listing

Deep learning applied to polysomnography to predict blood pressure in obstructive sleep apnea and obesity hypoventilation: a proof-of-concept study.

J Clin Sleep Med 2020 Jun 2. Epub 2020 Jun 2.

Section of Pulmonary and Critical Care, Sleep Disorders Center, University of Chicago, Chicago, Illinois.

Study Objectives: Nocturnal blood pressure (BP) profile shows characteristic abnormalities in obstructive sleep apnea (OSA), namely acute post-apnea BP surges and non-dipping BP. These abnormal BP profiles provide prognostic clues indicating increased cardiovascular disease (CVD) risk. We developed a deep neural network model to perform computerized analysis of polysomnography data and predict nocturnal BP profile. Read More

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http://dx.doi.org/10.5664/jcsm.8608DOI Listing

Respiratory Dysfunction and Sleep-Disordered Breathing in Children With Myasthenia Gravis.

J Child Neurol 2020 Jun 2:883073820924213. Epub 2020 Jun 2.

Department of Pediatrics, Division of Respirology, University of Toronto, Toronto, Ontario, Canada.

Objectives: The purpose of this study was to prospectively evaluate sleep patterns and the presence of sleep-disordered breathing in children with myasthenia gravis. We further aimed to examine the relationship between sleep and daytime respiratory function using spirometry tests including upright and supine forced vital capacity, sniff nasal inspiratory pressure, and maximal inspiratory pressure.

Methods: Eleven children between 3 and 18 years old with confirmed myasthenia gravis were recruited from The Hospital for Sick Children Neuromuscular Clinic in this prospective observational study. Read More

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http://dx.doi.org/10.1177/0883073820924213DOI Listing

Structural assessment of the optic nerve in patients with obstructive sleep apnea syndrome: Case-control study.

Eur J Ophthalmol 2020 Jun 2:1120672120926859. Epub 2020 Jun 2.

Süreyyapaşa Thoracic Diseases and Thoracic Surgery Hospital, Istanbul, Turkey.

Objective: Obstructive sleep apnea syndrome has been identified as a possible risk factor for optic nerve pathology such as glaucoma, nonarteritic ischemic optic neuropathy, and optic disk edema. Accordingly, we aimed to evaluate structural changes of the apparently normal optic nerve in obstructive sleep apnea syndrome patients with effects of its severity.

Materials And Methods: In this prospective case-control study, 47 eyes of 47 obstructive sleep apnea syndrome patients diagnosed with polysomnography and 40 eyes of 40 healthy subjects were included. Read More

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http://dx.doi.org/10.1177/1120672120926859DOI Listing

Refractory Acute Respiratory Distress Syndrome Secondary to COVID-19 Successfully Extubated to Average Volume-assured Pressure Support Non-invasive Ventilator.

Cureus 2020 Apr 27;12(4):e7849. Epub 2020 Apr 27.

Internal Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, West Virginia University, Morgantown, USA.

Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by the highly infectious novel SARS-CoV-2 coronavirus spread by droplet transmission. Consequently, the use of respiratory devices that may potentially promote aerosolization like non-invasive positive pressure ventilation (NIPPV) for diseases such as obstructive sleep apnea (OSA), advanced chronic obstructive lung disease, pulmonary hypertension (PH), and neuromuscular respiratory disease has been called into question. We present a case of a patient with history of OSA and PH convalescing from refractory acute respiratory distress syndrome (ARDS) secondary to COVID-19 who was successfully extubated to average volume-assured pressure support (AVAPS). Read More

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http://dx.doi.org/10.7759/cureus.7849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253078PMC

Preoperative Screening for Obstructive Sleep Apnea Using Alternative Scoring Models of the Sleep Tiredness Observed Pressure-Body Mass Index Age Neck Circumference Gender Questionnaire: An External Validation.

Anesth Analg 2020 May 29. Epub 2020 May 29.

From the Pôle Anesthésie Réanimation, Centre Hospitalier Universitaire (CHU) Grenoble Alpes, Grenoble, France.

Background: The Sleep Tiredness Observed Pressure-Body mass index Age Neck circumference Gender (STOP-Bang) questionnaire is a validated preoperative screening tool for identifying patients with obstructive sleep apnea (OSA). Although it has a high sensitivity at scores ≥3, its specificity is moderate, particularly for scores of 3-4. This study aimed to externally validate the STOP-Bang questionnaire and the alternative scoring models that have been proposed to improve its predictive performance. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004909DOI Listing

Laryngeal Botulinum Toxin Injection: Can It Be a Cause of Obstructive Sleep Apnea as an Adverse Effect?

J Voice 2020 May 30. Epub 2020 May 30.

Department of Chest Medicine, Sleep Disorders Center, University of Health Science, Dr. Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Izmir, Turkey.

Spasmodic dysphonia is a chronic voice disorder that is characterized by involuntary spasms of the laryngeal muscles during speech production. Botulinum toxin injection into to the laryngeal muscles is the most common and effective treatment of choice for symptoms of spasmodic dysphonia. We present a 44-year-old man with adductor spasmodic dysphonia who was diagnosed as having upper airway obstruction in a polysomnographic examination during sleep after a botulinum toxin injection. Read More

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http://dx.doi.org/10.1016/j.jvoice.2020.04.034DOI Listing

Prospective evaluation of Floppy Eyelid Syndrome at baseline and after CPAP therapy.

Curr Eye Res 2020 Jun 1. Epub 2020 Jun 1.

Ophathmology Department, Centro Hospitalar de Leiria , R. de Santo André, 2410-197 Leiria.

Purpose/aim: Floppy eyelid syndrome (FES) is an ocular manifestation of obstructive sleep apnea (OSA), but no studies have analyzed whether it can be improved by nocturnal continuous positive airway pressure (CPAP) therapy. The aim of this study was to analyze the effect of CPAP on FES by comparing objective measurements before and after 6 months of CPAP therapy.

Materials And Methods: We conducted a prospective study of 47 patients (74. Read More

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http://dx.doi.org/10.1080/02713683.2020.1776332DOI Listing

Cardiometabolic Benefits of a Weight-Loss Mediterranean Diet/Lifestyle Intervention in Patients with Obstructive Sleep Apnea: The "MIMOSA" Randomized Clinical Trial.

Nutrients 2020 May 28;12(6). Epub 2020 May 28.

Department of Nutrition & Dietetics, School of Health Science & Education, Harokopio University, 70 Eleftheriou Venizelou str., 17671 Athens, Greece.

Although continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep apnea (OSA), its cardiometabolic benefits are questionable. Our aim was to explore whether the combination of a weight-loss Mediterranean diet/lifestyle intervention with OSA standard care leads to greater cardiometabolic improvements compared with standard care alone. We randomly assigned 187 adult, overweight, polysomnography-diagnosed moderate-to-severe OSA patients to a standard care group (SCG, = 65), a Mediterranean diet group (MDG, = 62) or a Mediterranean lifestyle group (MLG, = 60). Read More

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http://dx.doi.org/10.3390/nu12061570DOI Listing

Prevalence of interstitial and other lung diseases on Aruba.

Sarcoidosis Vasc Diffuse Lung Dis 2017 9;34(3):217-225. Epub 2020 Mar 9.

ild care foundation research team, The Netherlands.

Health care management has to be based on the local prevalence of diseases and the local diagnostic and therapeutic needs. So far, no systematic registration system for various lung diseases exists on Aruba. Questions that need to be answered are: what specific lung disorders occur on Aruba, and what are the specific needs there? The aim of this study was to assess the prevalence of lung disorders and the diversity of the patient population. Read More

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http://dx.doi.org/10.36141/svdld.v34i3.6038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170099PMC

How might non nutritional sucking protect from sudden infant death syndrome.

Med Hypotheses 2020 May 22;143:109868. Epub 2020 May 22.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.

Epidemiology has identified an association between the use of pacifiers and protection from sudden infant death syndrome (SIDS). The use of pacifiers for SIDS prevention fails to gain adoption partly because there is no widely accepted physiologic mechanism to explain the epidemiologic association. Additionally, the scientific literature available on pacifier use focuses largely on the probable adverse effects. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109868DOI Listing

Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study.

Anatol J Cardiol 2020 Jun;23(6):334-341

Department of Chest Diseases, Faculty of Medicine, Ankara University; Ankara-Turkey.

Objective: Obstructive sleep apnea (OSA) is associated with elevated blood pressure (BP) and increases the risk of developing cardiovascular diseases. This study aimed to determine the clinical and polysomnographic features of OSA that are significantly associated with hypertension (HT).

Methods: This is a prospective study that enrolled patients diagnosed with OSA in Ankara University Faculty of Medicine from January 2015 to June 2016. Read More

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http://dx.doi.org/10.14744/AnatolJCardiol.2020.71429DOI Listing

Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA.

Front Cell Neurosci 2020 12;14:97. Epub 2020 May 12.

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China.

Studies have shown that diabetes can cause cognitive dysfunction, and cognitive dysfunction in patients with diabetes combined with obstructive sleep apnea (OSA) is more severe. LncRNAs are known to be associated with type 2 diabetes mellitus (T2DM) with OSA. This study aimed to investigate the role and underlying mechanism of the lncRNA MALAT1/miR-224-5p/NLRP3 axis in T2DM with OSA. Read More

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http://dx.doi.org/10.3389/fncel.2020.00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235443PMC

Edaravone improves intermittent hypoxia-induced cognitive impairment and hippocampal damage in rats.

Biol Pharm Bull 2020 May 30. Epub 2020 May 30.

Department of Respiratory Medicine, The First Hospital of Lanzhou University.

Oxidative stress plays an essential role in obstructive sleep apnea-hypopnea syndrome-induced cognitive dysfunction in children. This study investigated the effects of edaravone, a potent free radical scavenger, on intermittent hypoxia (IH)-induced oxidative damage and cognition impairment in a young rat model of IH. IH rats were treated with edaravone for 4 weeks. Read More

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http://dx.doi.org/10.1248/bpb.b20-00085DOI Listing

Comorbid sleep apnea, post-traumatic stress disorder, and insomnia: underlying mechanisms and treatment implications-a commentary on El Solh et al.'s Impact of low arousal threshold on treatment of obstructive sleep apnea in patients with post-traumatic stress disorder.

Sleep Breath 2020 May 30. Epub 2020 May 30.

The Adelaide Institute for Sleep Health: A Centre of Research Excellence, College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia.

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http://dx.doi.org/10.1007/s11325-020-02107-zDOI Listing

Injectable slurry for selective destruction of neck adipose tissue in New Zealand obese mouse model.

Sleep Breath 2020 May 30. Epub 2020 May 30.

Wellman Center for Photomedicine, Boston, MA, USA.

Purpose: Increased neck circumference is a major risk factor for obstructive sleep apnea (OSA). New data suggest that increased adipose tissue in the neck may be a contributory cause of OSA. The aim of this study was to investigate safety and efficacy of a recently developed injectable ice slurry in selective reduction of neck adipose tissue in a mouse model. Read More

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http://dx.doi.org/10.1007/s11325-020-02111-3DOI Listing

Vibration pattern recognition using a compressed histogram of oriented gradients for snoring source analysis.

Biomed Mater Eng 2020 May 27. Epub 2020 May 27.

School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, China.

Background: Snoring source analysis is essential for an appropriate surgical decision for both simple snorers and obstructive sleep apnea/hypopnea syndrome (OSAHS) patients.

Objective: As snoring sounds carry significant information about tissue vibrations within the upper airway, a new feature entitled compressed histogram of oriented gradients (CHOG) is proposed to recognize vibration patterns of the snoring source acoustically by compressing histogram of oriented gradients (HOG) descriptors via the multilinear principal component analysis (MPCA) algorithm.

Methods: Each vibration pattern corresponds to a sole or combinatorial vibration among the four upper airway soft tissues of soft palate, lateral pharyngeal wall, tongue base, and epiglottis. Read More

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http://dx.doi.org/10.3233/BME-201086DOI Listing

Obstructive sleep apnea syndrome as a potential cause of nocturia in younger adults.

Urology 2020 May 28. Epub 2020 May 28.

Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan.

Objectives: To investigate the impact of age on the relationship between obstructive sleep apnea syndrome (OSAS), nocturia, and other lower urinary tract symptoms (LUTSs).

Methods: This was a secondary analysis study based on data derived from a previously conducted prospective observational cohort study on OSAS and nocturia. We analyzed 90 subjects who were suspected of having OSAS. Read More

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http://dx.doi.org/10.1016/j.urology.2020.04.116DOI Listing

Association Between Breathing Route, Oxygen Desaturation, and Upper Airway Morphology.

Laryngoscope 2020 May 30. Epub 2020 May 30.

Department of Otolaryngology-Head and Neck Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Objectives/hypothesis: This study aimed to assess the role of capnography in objectively evaluating breathing routes during drug-induced sleep endoscopy (DISE) and further elucidate the relationship between breathing route, obstructive sleep apnea (OSA) severity, and DISE findings.

Study Design: Prospective observational study.

Methods: Nighty-five patients with established OSA were recruited for this study from May 2017 to May 2019. Read More

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http://dx.doi.org/10.1002/lary.28774DOI Listing

Variation in Sleep Stability with Differences in Severity of Sleep-Disordered Breathing in Children.

Laryngoscope 2020 May 30. Epub 2020 May 30.

Division of Rhinology & Sleep Medicine, Department of Otorhinolaryngology-Head and Neck Surgery , Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea.

Objectives: The aim of this study was to analyze the association between obstructive sleep apnea (OSA) severity and various cardiopulmonary coupling (CPC) parameters in children with OSA.

Study Design: Retrospective cross-sectional study.

Methods: A cross-sectional study was conducted among 117 children (aged 7. Read More

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http://dx.doi.org/10.1002/lary.28769DOI Listing

A COVID-19 Conundrum: Obstructive Sleep Apnea (OSA) and Non-Invasive Ventilation (NIV).

Authors:

Anesth Analg 2020 May 27. Epub 2020 May 27.

The challenges imposed by the COVID-19 pandemic become amplified in the setting of non-intubated patients with obstructive sleep apnea. Unlike the closed system that characterizes an intubated patient attached to a respiratory circuit, non-invasive ventilatory support threatens an increased risk of permeating the clinical workspace with airborne viral particles. Patients with sleep apnea may mandatorily require non-invasive ventilation strategies to see them through a respiratory illness. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004998DOI Listing

A Modified Cosmetic Genioplasty Can Affect Airway Space Positively in Skeletal Class II Patients: Studying Alterations of Hyoid Bone Position and Posterior Airway Space.

Aesthetic Plast Surg 2020 May 29. Epub 2020 May 29.

Plastic and Aesthetic Surgery Center, Hospital of Stomatology, Jilin University, No. 1500 Qinghua Road, Changchun, 130021, Jilin, China.

Background: Improving the posterior airway space is one of the most important functions of genioplasty. Studies have shown that the posterior airway space (PAS) can play an important role in the evaluation of obstructive sleep apnea syndrome (OSAS). The purpose of this study is to evaluate the airway safety of our modified technology by observing the impact on PAS in skeletal Class II patients without OSAS. Read More

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http://dx.doi.org/10.1007/s00266-020-01790-3DOI Listing

CPAP is associated with decreased risk of AF recurrence in patients with OSA, especially those younger and slimmer: a meta-analysis.

J Interv Card Electrophysiol 2020 May 29. Epub 2020 May 29.

Department of Otolaryngology Head & Neck Surgery, Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Anzhen Hospital, Capital Medical University, No 2, Anzhen Road, Chaoyang District, Beijing, 100029, China.

Purpose: Obstructive sleep apnea (OSA) is associated with the management of atrial fibrillation (AF). This manuscript aims to discuss the effects of continuous positive airway pressure (CPAP) in patients with rhythm control strategies and patients with different ages, weights and length of follow-up.

Methods: We searched Embase, PubMed, Cochrane, Web of Science and Ovid for relevant studies (from inception to 7 July 2019; English). Read More

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http://dx.doi.org/10.1007/s10840-020-00738-6DOI Listing

The Neuropsychological Profile of Attention Deficits of Patients with Obstructive Sleep Apnea: An Update on the Daytime Attentional Impairment.

Brain Sci 2020 May 27;10(6). Epub 2020 May 27.

"V. Fazzi" Hospital, ENT, ASL, 73100 Lecce, Italy.

Introduction: Patients with obstructive sleep apnea (OSA) suffer from several neurocognitive disturbances. One of the neuropsychological processes most investigated in OSA patients is attention, but the results have been controversial. Here, we update the attention profile of OSA patients with the final aim to improve attention assessment, with a possible impact on clinical and medical-legal practices, in terms of which attention subdomains and parameters need consideration and which one is a high-risk OSA phenotype for attention dysfunctions. Read More

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http://dx.doi.org/10.3390/brainsci10060325DOI Listing

Estimation of the hyperelastic parameters of fresh human oropharyngeal soft tissues using indentation testing.

J Mech Behav Biomed Mater 2020 Aug 18;108:103798. Epub 2020 Apr 18.

Robarts Research Institute, Western University, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada; Department of Electrical and Computer Engineering, Western University, London, Ontario, Canada; Biomedical Engineering Graduate Program, Western University, London, Ontario, Canada. Electronic address:

Patient-specific finite element (FE) modeling of the upper airway is an effective tool for accurate assessment of obstructive sleep apnea (OSA) syndrome. It is also useful for planning minimally invasive surgical procedures under severe OSA conditions. A major requirement of FE modeling is having reliable data characterizing the biomechanical properties of the upper airway tissues, particularly oropharyngeal soft tissue. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2020.103798DOI Listing

Evaluation of neurocognitive abilities in children affected by obstructive sleep apnea syndrome before and after adenotonsillectomy.

Acta Otorhinolaryngol Ital 2020 Apr;40(2):122-132

Otolaryngology, Head and Neck Surgery, Department of General and Specialistic Surgery, University of Campania "Luigi Vanvitelli", Italy.

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http://dx.doi.org/10.14639/0392-100X-N0267DOI Listing

A detection dog for obstructive sleep apnea: could it work in diagnostics?

Sleep Breath 2020 May 29. Epub 2020 May 29.

Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, PO Box 263, HUS, 00029, Helsinki, Finland.

Purpose: We have previously demonstrated that dogs can be trained to distinguish the urine of patients with obstructive sleep apnea (OSA) from that of healthy controls based on olfaction. Encouraged by these promising results, we wanted to investigate if a detection dog could work as a screening tool for OSA. The objective of this study was to prospectively assess the dogs' ability to identify sleep apnea in patients with OSA suspicion. Read More

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http://dx.doi.org/10.1007/s11325-020-02113-1DOI Listing

Relationship between HIF-1 and Circadian Clock Proteins in Obstructive Sleep Apnea Patients-Preliminary Study.

J Clin Med 2020 May 25;9(5). Epub 2020 May 25.

Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, Poland.

Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia and associated with the disruption of circadian rhythm. The study aimed to assess the relationship between hypoxia-inducible factor (HIF) subunits, circadian clock proteins, and polysomnography (PSG) variables, in healthy individuals and severe OSA patients. The study included 20 individuals, who underwent PSG and were divided into severe OSA group ( = 10; AHI ≥ 30) and healthy control ( = 10; AHI < 5) based on apnea-hypopnea index (AHI). Read More

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http://dx.doi.org/10.3390/jcm9051599DOI Listing

Peak Oxygen Consumption and Survival after Heart Transplant is Similar in Patients with and without Comorbid Obstructive Sleep Apnea.

J Heart Lung Transplant 2020 Apr 30;39(4S):S257. Epub 2020 Mar 30.

Heart and Vascular Center, University of Pennsylvania, Philadelphia, PA.

Purpose: Obstructive sleep apnea (OSA) is associated with increased all-cause and cardiovascular mortality in the general population and may be associated with decreased exercise capacity on cardiopulmonary exercise testing (CPET). While comorbid OSA is often considered when evaluating patients for heart transplantation, post-transplant outcomes are poorly studied.

Methods: We conducted a retrospective analysis of 307 heart transplant recipients at a large academic institution with CPET ≤2 years after transplant. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.557DOI Listing

Association between central sleep apnea and atrial fibrillation/flutter in Japanese-American men: The Kuakini Honolulu Heart Program (HHP) and Honolulu-Asia Aging Study (HAAS).

J Electrocardiol 2020 May 12;61:10-17. Epub 2020 May 12.

University of Hawai'i at Mānoa, Department of Geriatric Medicine, John A. Burns School of Medicine, 347 N Kuakini St, Honolulu, HI, USA; Kuakini Medical Center, 347 N Kuakini St, Honolulu, HI, USA. Electronic address:

Introduction: While several studies have indicated that central sleep apnea (CSA) is associated with atrial fibrillation and atrial flutter (AF) in older populations, few studies have focused on older Asian populations.

Methods: We conducted a cross- sectional analysis using data from the 1999-2000, 7th exam cycle of the Kuakini Honolulu-Asia Aging Study. Participants were 718 Japanese-American men between 79 and 97 years old, who had overnight polysomnography. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2020.05.005DOI Listing

Belun Ring Platform: a novel home sleep apnea testing system for assessment of obstructive sleep apnea.

J Clin Sleep Med 2020 May 22. Epub 2020 May 22.

Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Study Objectives: The objective of the study is to validate the performance of Belun Ring Platform, a novel home sleep apnea testing system using a patented pulse oximeter sensor and a proprietary cloud-based neural networks algorithm.

Methods: The Belun Ring captures oxygen saturation (SpO2), Photoplethysmography (PPG), and accelerometer signals. The Belun Ring Total sleep time (Ring-TST) is derived from features extracted from accelerometer, SpO2, and PPG signals. Read More

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http://dx.doi.org/10.5664/jcsm.8592DOI Listing

Do Young Children With Nonsevere Obstructive Sleep Apnea Benefit From Adenotonsillectomy?: The CHAT vs the KATE Study.

JAMA Otolaryngol Head Neck Surg 2020 May 28. Epub 2020 May 28.

Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia.

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http://dx.doi.org/10.1001/jamaoto.2020.0878DOI Listing

Effectiveness of Adenotonsillectomy vs Watchful Waiting in Young Children With Mild to Moderate Obstructive Sleep Apnea: A Randomized Clinical Trial.

JAMA Otolaryngol Head Neck Surg 2020 May 28. Epub 2020 May 28.

Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Importance: Adenotonsillectomy (ATE) is one of the most common surgical procedures to treat children with obstructive sleep apnea (OSA), but to our knowledge there are no randomized clinical trials confirming the benefit of surgery compared with watchful waiting in children between 2 and 4 years of age.

Objective: To determine whether ATE is more effective than watchful waiting for treating otherwise healthy children with mild to moderate OSA.

Design, Setting, And Participants: This randomized clinical trial was conducted from December 2014 to December 2017 at the Otorhinolaryngology Department of the Karolinska University Hospital, Stockholm, Sweden. Read More

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http://dx.doi.org/10.1001/jamaoto.2020.0869DOI Listing

[Obesity and risk of severe COVID-19].

Authors:
André J Scheen

Rev Med Suisse 2020 May;16(695):1115-1119

Service de diabétologie, nutrition et maladies métaboliques, Département de médecine, CHU Liège, Liège Université, 4000 Liège, Belgique.

Obesity represents a higher risk of severe COVID-19 infection, which may lead to the requirement of a mechanical ventilation in intensive care units and premature death. The underlying mechanisms are multiple: alteration of the respiratory performance, presence of comorbidities such as diabetes, hypertension or obstructive sleep apnea, finally inadequate and excessive immunological responses, possibly aggravated by ectopic intrathoracic fat depots. Thus, COVID-19 may challenge the so-called « obesity paradox » commonly reported by intensivists in patients with acute respiratory distress syndrome. Read More

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Estimating daytime sleepiness with previous night EEG, EOG and EMG spectrograms in patients with suspected sleep apnea using a convolutional neural network.

Sleep 2020 May 27. Epub 2020 May 27.

Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.

A common symptom of obstructive sleep apnea (OSA) is excessive daytime sleepiness (EDS). The gold standard test for EDS is the multiple sleep latency test (MSLT). However, due to its high cost, MSLT is not routinely conducted for OSA patients and EDS is instead evaluated using sleep questionnaires. Read More

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http://dx.doi.org/10.1093/sleep/zsaa106DOI Listing

[Dental sleep medicine: A further introduction to an emerging dental discipline].

Authors:
F Lobbezoo G Aarab

Ned Tijdschr Tandheelkd 2020 Apr;127(4):222-230

Dental sleep medicine is a discipline traditionally focusing on sleep-breathing disorders like snoring and obstructive sleep apnea. In everyday clinical practice, however, such disorders rarely occur in isolation. Rather, they frequently co-occur with other sleep disorders linked to dentistry, such as orofacial pain, dry mouth, hypersalivation, gastroesophageal reflux, and sleep bruxism. Read More

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http://dx.doi.org/10.5177/ntvt.2020.04.20006DOI Listing