28,600 results match your criteria Obstructive Sleep Apnea-Hypopnea Syndrome


International Continence Society consensus on the diagnosis and treatment of nocturia.

Neurourol Urodyn 2019 Feb 19. Epub 2019 Feb 19.

Urology Department, University of Philadelphia, Philadelphia, Pennsylvania.

Introduction: Patients with nocturia have to face many hurdles before being diagnosed and treated properly. The aim of this paper is to: summarize the nocturia patient pathway, explore how nocturia is diagnosed and treated in the real world and use the Delphi method to develop a practical algorithm with a focus on what steps need to be taken before prescribing desmopressin.

Methods: Evidence comes from existing guidelines (Google, PubMed), International Consultation on Incontinence-Research Society (ICI-RS) 2017, prescribing information and a Delphi panel (3 rounds). Read More

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http://dx.doi.org/10.1002/nau.23939DOI Listing
February 2019

Treatment of sleep-disordered breathing with positional therapy: long-term results.

Sleep Breath 2019 Feb 18. Epub 2019 Feb 18.

Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.

Purpose: The aim of the present study was to assess the efficacy of a sleep position trainer (SPT) in patients with an established diagnosis of positional obstructive sleep apnea and to evaluate the adherence after 1-year follow-up.

Methods: Polysomnography (PSG) was performed at baseline and after 1 year of SPT use. Patients received questionnaires to assess treatment satisfaction and subjective adherence. Read More

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http://dx.doi.org/10.1007/s11325-019-01792-9DOI Listing
February 2019

Monocytic C-C chemokine receptor 5 expression increases in in vitro intermittent hypoxia condition and in severe obstructive sleep apnea patients.

Sleep Breath 2019 Feb 18. Epub 2019 Feb 18.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.

Purpose: Obstructive sleep apnea (OSA) patients have higher risk of cardiovascular disease. C-C chemokine receptor 5 (CCR5), as an important receptor for monocyte recruitment and the initiation of atherosclerosis, was studied under intermittent hypoxia and in OSA patients.

Methods: The expression and function of CCR5 regulated by intermittent hypoxia in monocytic THP-1 cells were investigated in an in vitro intermittent hypoxia culture system. Read More

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http://dx.doi.org/10.1007/s11325-019-01797-4DOI Listing
February 2019
2.869 Impact Factor

Finding a needle in the haystack-narcolepsy and obstructive sleep apnea.

Sleep Breath 2019 Feb 18. Epub 2019 Feb 18.

Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925 - 2° andar, Vila Clementino, São Paulo, 04024-002, Brazil.

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http://dx.doi.org/10.1007/s11325-019-01800-yDOI Listing
February 2019

Mandibular distraction osteogenesis versus sagittal split ramus osteotomy in managing obstructive sleep apnea: A randomized clinical trial.

J Craniomaxillofac Surg 2019 Feb 5. Epub 2019 Feb 5.

Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong. Electronic address:

Purpose: To compare mandibular distraction osteogenesis (MDO) to sagittal split ramus osteotomy (SSRO) to treat moderate-to-severe obstructive sleep apnea (OSA), and their surgical morbidities and skeletal stability.

Materials And Methods: A randomized clinical trial was conducted on non-syndromic adult patients with apnea-hypopnea index (AHI) 15 or above to receive MDO or SSRO as part or whole skeletal advancement surgery. Post-operative 1 year OSA cure rate (AHI < 5/hour) and treatment success rate (50% reduction of AHI and AHI< 20/hour) were compared. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.01.046DOI Listing
February 2019

A Simple Protocol to Stratify Pulmonary Risk Reduces Complications After Total Joint Arthroplasty.

J Arthroplasty 2019 Jan 29. Epub 2019 Jan 29.

Department of Orthopaedic Surgery, Rothman Orthopaedics at Thomas Jefferson University, Egg Harbor Township, NJ.

Background: Pulmonary complications after total joint arthroplasty are a burden to patients and the healthcare system. The aim of this study is to demonstrate the effectiveness of a pulmonary screening questionnaire and intervention protocol developed at our institution to prevent pulmonary complications.

Methods: Between 2010 and 2015, 7658 consecutive total joint arthroplasty patients at our institution were reviewed. Read More

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http://dx.doi.org/10.1016/j.arth.2019.01.048DOI Listing
January 2019

Surgery for Obstructive Sleep Apnea in Obese Children: Literature Review and Meta-analysis.

Otolaryngol Head Neck Surg 2019 Feb 19:194599819829415. Epub 2019 Feb 19.

1 Department of Otolaryngology-Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Objectives: Surgical intervention for obstructive sleep apnea (OSA) in overweight and obese children may not be as effective as it is in normal-weight children. The purpose of this study was to systematically review the effects of various surgical interventions for OSA in obese children and to meta-analyze the current data.

Data Sources: PubMed, OVID, and Cochrane databases. Read More

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http://dx.doi.org/10.1177/0194599819829415DOI Listing
February 2019

Clinical Characteristics, Complications, and Reasons for Readmission following Lingual Tonsillectomy.

Otolaryngol Head Neck Surg 2019 Feb 19:194599819827820. Epub 2019 Feb 19.

2 Department of Otology & Laryngology, Harvard Medical School, Boston, Massachusetts, USA.

This brief communication regards the indications and complications for and rates of readmission following lingual tonsillectomy. The National Readmissions Database (NRD) 2013-2014 was queried for all cases of lingual tonsillectomy occurring from 2013 to 2014. Among 602 lingual tonsillectomies (mean age 36. Read More

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http://dx.doi.org/10.1177/0194599819827820DOI Listing
February 2019

The first night effect during polysomnography, and patients' estimates of sleep quality.

Psychiatry Res 2019 Feb 6;274:27-29. Epub 2019 Feb 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea. Electronic address:

We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.011DOI Listing
February 2019

Outcome of drug-induced sleep endoscopy-directed surgery for persistent obstructive sleep apnea after adenotonsillar surgery.

Int J Pediatr Otorhinolaryngol 2019 Feb 6;120:118-122. Epub 2019 Feb 6.

Nursing Service, Hospital Universitari General de Catalunya, Sant Cugat del Vallès, Barcelona, Spain; Sant Ildefons Cornellà Health Centre, Institut Català de la Salut, Spain.

Purpose: Drug-induced sleep endoscopy (DISE) is suitable for evaluating persistent obstructive sleep apnea syndrome (OSAS) after adenotonsillar surgery as a means to guide surgical intervention, yet few studies demonstrate its usefulness in resolving the syndrome. We describe our experience of DISE-directed surgery in children with persistent OSAS by analysing objective and subjective outcomes of this treatment.

Methods: Prospective study of 20 otherwise healthy 2-12 year-old children with OSAS persisting after adenotonsillar surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193006
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http://dx.doi.org/10.1016/j.ijporl.2019.02.004DOI Listing
February 2019
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Does drug induced sleep endoscopy-directed surgery improve polysomnography measures in children with Down Syndrome and obstructive sleep apnea?

Acta Otolaryngol 2018 Nov;138(11):1009-1013

c Pediatric Otolaryngology , Seattle Children's Hospital , Seattle , WA , USA.

Background: Children with Down Syndrome (DS) and obstructive sleep apnea (OSA) are difficult to treat, as first line therapies may not lead to significant improvement. Drug-induced sleep endoscopy (DISE) directed surgery may be particularly beneficial for these patients.

Objective: To assess change in polysomnography (PSG) measures of patients with DS who underwent DISE-directed surgery. Read More

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http://dx.doi.org/10.1080/00016489.2018.1504169DOI Listing
November 2018

Cautery-assisted palatal stiffening operation for obstructive sleep apnea: A systematic review and meta-analysis.

World J Otorhinolaryngol Head Neck Surg 2019 Mar 25;5(1):49-56. Epub 2018 Sep 25.

Tripler Army Medical Center, Division of Otolaryngology, Sleep Surgery and Sleep Medicine, Tripler AMC, 1 Jarrett White Rd, HI 96859, USA.

Objective: To systematically review outcomes for cautery-assisted palatal stiffening operation (CAPSO) as a treatment for adult obstructive sleep apnea (OSA).

Methods: Five databases (including PubMed/MEDLINE) were searched through July 12, 2017.

Results: Eight studies (307 patients) met criteria. Read More

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http://dx.doi.org/10.1016/j.wjorl.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364515PMC

The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis.

World J Otorhinolaryngol Head Neck Surg 2019 Mar 25;5(1):41-48. Epub 2018 Sep 25.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.

Objectives: Obstructive sleep apnea (OSA) is a prevalent disease with significant health impacts. While first line therapy is CPAP, long-term compliance is low and device misuse is common, highlighting the need for alternative therapies. Upper airway surgery is one alternative, but substantial side effects hamper efficacy. Read More

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http://dx.doi.org/10.1016/j.wjorl.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364516PMC

Floppy eyelid syndrome in stickler syndrome.

Am J Ophthalmol Case Rep 2019 Jun 31;14:14-15. Epub 2019 Jan 31.

Department of Ophthalmology, Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.

Purpose: To report the possible connection between Stickler syndrome and floppy eyelid syndrome.

Observations: A 36-year-old man with genetically confirmed Stickler syndrome presented with prominent bilateral eyelid laxity consistent with floppy eyelid syndrome. He had a high-arched palate and reported years of apneic episodes during sleep consistent with obstructive sleep apnea (OSA). Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365810PMC

Cardiotrophin-1 and leptin as cardiovascular risk markers in male patients with obstructive sleep apnea syndrome.

Arch Med Sci Atheroscler Dis 2018 6;3:e123-e128. Epub 2018 Nov 6.

Clinics of Chest Diseases, Kayseri Education and Research Hospital, Kayseri, Turkey.

Introduction: Elevated cardiotrophin-1 (CT-1) and leptin levels are important risk factors for cardiovascular diseases (CVDs). Obstructive sleep apnea syndrome (OSAS) has also been reported to increase this risk. The aim of this study is to evaluate serum concentrations of CT-1 and leptin in patients with OSAS and whether there is a possible association between CT-1, leptin and OSAS severity. Read More

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http://dx.doi.org/10.5114/amsad.2018.79407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374564PMC
November 2018

Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea.

Clin Interv Aging 2019 31;14:241-247. Epub 2019 Jan 31.

Department of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan,

Objectives: To assess the effect of continuous positive airway pressure (CPAP) on nocturia in ischemic stroke patients with obstructive sleep apnea (OSA).

Methods: This was a prospective and non-randomized controlled study in which ischemic stroke patients with OSA being treated in a rehabilitation ward were enrolled. The participants who tolerated CPAP were classified as the CPAP group, while those who refused or could not tolerate CPAP were classified as the control group. Read More

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http://dx.doi.org/10.2147/CIA.S193448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362916PMC
January 2019

Patient-Reported Triggers of Paroxysmal Atrial Fibrillation.

Heart Rhythm 2019 Jan 30. Epub 2019 Jan 30.

Division of Cardiology; University of California, San Francisco; San Francisco, CA. Electronic address:

Background: Triggers for discrete atrial fibrillation (AF) events remain poorly studied and incompletely characterized.

Objective: The present study describes common triggers for AF and their relationships with patient characteristics.

Methods: We invited symptomatic, paroxysmal AF patients enrolled in the Health eHeart Study and through the patient-centered advocacy organization StopAfib. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.01.027DOI Listing
January 2019

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities.

J Am Acad Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Baylor Scott and White, Dallas, Texas.

Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations on the basis of available evidence. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.058DOI Listing
February 2019

Natural history of ventriculomegaly in adults: a cluster analysis.

J Neurosurg 2019 Feb 8:1-8. Epub 2019 Feb 8.

OBJECTIVEChronic ventriculomegaly in the absence of raised intracranial pressure (ICP) is a known entity in adult hydrocephalus practice. The natural history and indication for treatment is, however, poorly defined. A highly heterogeneous group, some adults with ventriculomegaly are asymptomatic, while others have life-threatening deteriorations. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18119DOI Listing
February 2019
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Marital quality, partner's engagement and continuous positive airway pressure adherence in obstructive sleep apnea.

Sleep Med 2018 Dec 26;55:56-61. Epub 2018 Dec 26.

HP2 Laboratory, INSERM U1042, Univ. Grenoble Alpes, Grenoble, France; EFCR Laboratory, Grenoble Alpes University Hospital, Grenoble, France. Electronic address:

Background: Continuous positive airway pressure (CPAP) is the first line therapy for obstructive sleep apnea (OSA) but its effectiveness requires high adherence. We aimed to assess the impacts of the spouse's/partner's involvement and the quality of the couple's relationship on CPAP adherence.

Methods: In a multicenter prospective study conducted in France, patients reported their subjective views regarding their partner's engagement in their CPAP treatment and the quality of their marital relationship using the Quality of Marriage Index. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.009DOI Listing
December 2018

Investigation of Urinary Sestrin2 in Patients with Obstructive Sleep Apnea.

Lung 2019 Feb 15. Epub 2019 Feb 15.

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.

Background: Obstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Sestrin2 is a crucial factor involved in oxidative stress. Read More

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http://dx.doi.org/10.1007/s00408-019-00205-8DOI Listing
February 2019

[Integration of Micro Sensors with Mobile Devices for Monitoring Vital Signs of Sleep Apnea Patients].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):29-31

Wenzhou Central Hospital, Wenzhou, 325000.

This paper demonstrates a BSN-based portable monitor integrating micro sensors with mobile devices for monitoring and diagnosing obstructive sleep apnea syndrome (OSAS) at home. The system uses a micro hot-film flow sensor to detect respiratory flow, uses tri-axis micro accelerometer to detect body posture and motion intensity, and uses a micro photoelectric sensor to detect oxygen saturation of blood. The real-time vital signs are detected and transmitted wirelessly to a mobile device. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.008DOI Listing
January 2019

Nightmare disorder and REM sleep behavior disorder in inflammatory arthritis: Possibility beyond neurodegeneration.

Brain Behav 2019 Feb 15:e01230. Epub 2019 Feb 15.

Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy.

Objectives: To investigate the prevalence of REM sleep behavior disorder (RBD) in patients with inflammatory arthritis (IA) to ascertain if RBD could be an internal red flag signaling a fluctuating state of inflammation based on the theory of "protoconsciousness".

Materials & Methods: One hundred and three patients with a confirmed diagnosis of IA were consecutively recruited. The patients underwent general (IA activity, functional status, laboratory tests) and neurological evaluations. Read More

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http://dx.doi.org/10.1002/brb3.1230DOI Listing
February 2019

Routine preoperative obstructive sleep apnea screening of elective surgical patients: a single-centre three-month experience.

Can J Anaesth 2019 Feb 14. Epub 2019 Feb 14.

Department of Anesthesia and Perioperative Care, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s12630-019-01318-7DOI Listing
February 2019

Non-exercise activity thermogenesis in obstructive sleep apnea: a pilot study.

Sleep Med 2018 Dec 26. Epub 2018 Dec 26.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, MN, United States; Center for Sleep Medicine, Mayo Clinic, MN, United States.

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http://dx.doi.org/10.1016/j.sleep.2018.12.008DOI Listing
December 2018

Symptom Subtypes of Obstructive Sleep Apnea Predict Incidence of Cardiovascular Outcomes.

Am J Respir Crit Care Med 2019 Feb 15. Epub 2019 Feb 15.

University of Pennsylvania Perelman School of Medicine, 14640, Division of Sleep Medicine, Department of Medicine, Philadelphia, Pennsylvania, United States.

Rationale: Symptom subtypes have been described in clinical and population samples of obstructive sleep apnea (OSA) patients. It is unclear whether these subtypes have different cardiovascular consequences.

Objectives: This study aimed to characterize OSA symptom subtypes and assess their association with prevalent and incident cardiovascular disease in the Sleep Heart Health Study. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201808-1509OC
Publisher Site
http://dx.doi.org/10.1164/rccm.201808-1509OCDOI Listing
February 2019
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Screening for High Risk of Sleep Apnea in an Ambulatory Care Setting in Saudi Arabia.

Int J Environ Res Public Health 2019 Feb 5;16(3). Epub 2019 Feb 5.

Department of Family Medicine, King Faisal Specialist Hospital and Research Centre, Jeddah 40047, Saudi Arabia.

Sleep apnea is a potentially serious but under-diagnosed sleep disorder. Saudi Arabia has a high prevalence of hypertension, diabetes, obesity, and smoking, which are all major risk factors for sleep apnea. However, few studies report screening for sleep apnea in Saudi Arabia. Read More

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http://dx.doi.org/10.3390/ijerph16030459DOI Listing
February 2019

The reduction of apnea-hypopnea duration ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in a rat model of obstructive sleep apnea.

Sleep Breath 2019 Feb 14. Epub 2019 Feb 14.

Beijing An Zhen Hospital, Capital Medical University, #2 Anzhen Road, Chaoyang District, Beijing, 100029, People's Republic of China.

Purpose: We aimed to investigate the effect of obstructive sleep apnea (OSA) and apnea-hypopnea duration on endothelial, ventricular function, blood pressure, and inflammation in a rat model.

Methods: We established a novel rat model of OSA. Wistar rats were randomized to six groups according to 4-week different treatments: (1) OSA (apnea for 60 s in a 90-s window of breathing [60 s/90 s] with anesthesia), (2) OSA 30 s/90 s with anesthesia, (3) partial recovery (60 s/90 s for 2 weeks, followed by 15 s/90 s for 2 weeks with anesthesia), (4) complete recovery (60 s/90 s for 2 weeks with anesthesia, and then normal breathing for 2 weeks), (5) sham (normal breathing in the device with anesthesia), and (6) control group (normal breathing, normal cage, no anesthesia). Read More

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http://dx.doi.org/10.1007/s11325-019-01798-3DOI Listing
February 2019

Stroke during sleep and obstructive sleep apnea: there is a link.

Neurol Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, King Saud University, Riyadh, Saudi Arabia.

Objectives: The onset of ischemic stroke symptoms has been established to have a diurnal variation, with a sizeable proportion (8-28%) occurring during sleep. Obstructive sleep apnea (OSA) has been established as an important risk factor for ischemic stroke. However, data on the relationship between OSA and wake-up stroke (WUS) has been scarce. Read More

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http://dx.doi.org/10.1007/s10072-019-03753-2DOI Listing
February 2019

Obstructive sleep apnea and quality of life in elderly patients with a pacemaker.

J Bras Pneumol 2019 Feb 11;45(1):e20170333. Epub 2019 Feb 11.

. Universidade de Pernambuco - UPE - Recife (PE) Brasil.

Objective: To evaluate quality of life in elderly patients with obstructive sleep apnea (OSA) who have a pacemaker.

Methods: This was a cross-sectional study involving elderly patients (≥ 60 years of age) with a pacemaker. The dependent variable was quality of life, as evaluated with the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36). Read More

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http://dx.doi.org/10.1590/1806-3713/e20170333DOI Listing
February 2019
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Cardiac Sympathetic Denervation Suppresses Atrial Fibrillation and Blood Pressure in a Chronic Intermittent Hypoxia Rat Model of Obstructive Sleep Apnea.

J Am Heart Assoc 2019 Feb;8(4):e010254

1 Department of Cardiothoracic Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu People's Republic of China.

Background Chronic intermittent hypoxia ( CIH ) is a distinct pathological mechanism of obstructive sleep apnea ( OSA ), which is recognized as an independent risk factor for cardiovascular diseases. The aims of this study were to ascertain whether CIH induces atrial fibrillation ( AF ), to determine whether cardiac sympathetic denervation ( CSD ) can prevent it and suppress blood pressure, and to explore the potential molecular mechanisms involved. Methods and Results Sixty Sprague-Dawley male rats were randomly divided into 4 groups: sham, CSD , CIH , CIH + CSD . Read More

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http://dx.doi.org/10.1161/JAHA.118.010254DOI Listing
February 2019
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Identification of dysregulation of atrial proteins in rats with chronic obstructive apnea using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry.

J Cell Mol Med 2019 Feb 12. Epub 2019 Feb 12.

Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, New York.

Obstructive sleep apnea (OSA) affects an estimated 20% of adults worldwide and has been associated with electrical and structural abnormalities of the atria, although the molecular mechanisms are not well understood. Here, we used two-dimensional polyacrylamide gel electrophoresis (2D PAGE) coupled with nanoliquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) to investigate the proteins that are dysregulated in the atria from severe and moderate apnea when compared to control. We found enzymes involved in the glycolysis, beta-oxidation, electron transport chain and Krebs cycle to be down-regulated. Read More

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http://dx.doi.org/10.1111/jcmm.14131DOI Listing
February 2019
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Current Smoking: An Independent Predictor of Elevated A1C in Persons With Type 2 Diabetes.

Diabetes Educ 2019 Feb 12:145721719829068. Epub 2019 Feb 12.

School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania.

Purpose: The purpose of this study is to examine the association of current smoking as one of several potential predictors of elevated A1C in adults with type 2 diabetes (T2D).

Methods: Using a cross-sectional design, baseline data (N = 282) were analyzed from a randomized clinical trial examining treatment of obstructive sleep apnea in persons with T2D. Sociodemographic, clinical, and behavioral data were collected using questionnaires and physical examinations. Read More

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http://dx.doi.org/10.1177/0145721719829068DOI Listing
February 2019
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Evaluation of cranial base repair techniques utilizing a novel cadaveric CPAP model.

Int Forum Allergy Rhinol 2019 Feb 12. Epub 2019 Feb 12.

Department of Otolaryngology-Head & Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA.

Background: Although recent guidelines for obstructive sleep apnea recommend early postoperative use of continuous positive airway pressure (CPAP) after endonasal skull base surgery, the time of initiation of CPAP is unclear. In this study we used a novel, previously validated cadaveric model to analyze the pressures delivered to the cranial base and evaluate the effectiveness of various repair techniques to withstand positive pressure.

Methods: Skull base defects were surgically created in 3 fresh human cadaver heads and repaired using 3 commonly used repair techniques: (1) Surgicel™ onlay; (2) dural substitute underlay with dural sealant onlay; and (3) dural substitute underlay with nasoseptal flap onlay with dural sealant. Read More

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http://dx.doi.org/10.1002/alr.22313DOI Listing
February 2019
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Potential contribution of microRNA-125b targeting p38MAPK to relieving intermittent hypoxia-induced dementia of mice models.

Curr Neurovasc Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Shanghai Eighth People's Hospital, Shanghai. China.

Introduction: The purpose of this investigation was to elucidate whether miR-125b targeting p38MAPK could relieve cognitive impairment of obstructive sleep apnea hypopnea syndrome (OSAHS) mice models.

Material And Methods: The mice models were categorized into untreated control (UC), 10% continuous hypoxic (CH), 10% chronic intermittent hypoxia (CIH) and 5% chronic intermittent hypoxia (CIH) groups. Morris Water Maze, spatial navigation test and spatial probe test were conducted to appraise the learning, memorizing and cognitive abilities of mice models. Read More

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http://dx.doi.org/10.2174/1567202616666190211155309DOI Listing
February 2019
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The effect of continuous positive airway pressure on pulmonary function may depend on the basal level of forced expiratory volume in 1 second.

J Thorac Dis 2018 Dec;10(12):6819-6827

Pulmonary Rehabilitation Unit, Istituti Clinici Scientifici Maugeri, Pavia, Italy.

Background: The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), also referred to as overlap syndrome (OS), is associated with a high rate of morbidity, COPD exacerbations and mortality. Treatment with continuous positive airway pressure (CPAP) has proven to significantly decrease the rate of these complications. However, data concerning the effect of CPAP on pulmonary function are scarce and conflicting. Read More

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http://dx.doi.org/10.21037/jtd.2018.10.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344686PMC
December 2018
2 Reads

Age-stratified sex differences in polysomnographic findings and pharyngeal morphology among children with obstructive sleep apnea.

J Thorac Dis 2018 Dec;10(12):6702-6710

Department of Otorhinolaryngology, Head and Neck Surgery, Juntendo University School of Medicine, Tokyo, Japan.

Background: Childhood obstructive sleep apnea (OSA) has important implications for growth, learning, behavior, cognition and cardiovascular health as well as snoring and OSA in adulthood. In this study, we elucidated the sex differences in polysomnographic (PSG) findings and pharyngeal radiographic data in pediatric OSA patients.

Methods: Sixty three children (age between 3 and 15 years old) with OSA [defined as apnea-hypopnea index (AHI) ≥1/h by polysomnography] were enrolled. Read More

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http://dx.doi.org/10.21037/jtd.2018.11.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344771PMC
December 2018
1 Read

Hematological indices as simple, inexpensive and practical severity markers of obstructive sleep apnea syndrome: a meta-analysis.

J Thorac Dis 2018 Dec;10(12):6509-6521

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

Background: Clinical detection of inflammatory markers is useful to assess the degree of nocturnal hypoxia and predict the presence of complications in obstructive sleep apnea syndrome (OSAS) patients. Nowadays, some researchers proposed that hematological parameters could be substituted for novel disease-specific biochemical markers (such as C-reactive protein) because they were comparatively cheap, simple and practical. But there was a contradiction whether the hematological parameters were positively correlated with the OSAS severity. Read More

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http://dx.doi.org/10.21037/jtd.2018.10.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344721PMC
December 2018
1 Read

Quality of an ambulatory monitoring technique for diagnosing obstructive sleep apnea under conditions of limited resources.

Sleep Sci 2018 Jul-Aug;11(4):269-273

National Institute of Respiratory Diseases, Sleep Medicine Unit - Mexico - Mexico City - Mexico.

Objectives: To: 1) evaluate the quality of an ambulatory monitoring technique for diagnosing Obstructive Sleep Apnea Syndrome (OSAS) while patients move through the city; and 2) identify factors that lead to data loss.

Methods: Clinical histories were reviewed and ambulatory portable monitorings of adults with high pretest probability for OSAS were included, the signals monitored were pulse oximetry, heart rate, nasal pressure, snoring, chest band and body position. The equipment was connected from 14:00-20:00 h and then patients moved through the city turning it off and on at home. Read More

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http://www.gnresearch.org/doi/10.5935/1984-0063.20180042
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http://dx.doi.org/10.5935/1984-0063.20180042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361307PMC
February 2019
3 Reads

Sleep disturbances, academic performance, depressive symptoms and substance use among medical students in Bogota, Colombia.

Sleep Sci 2018 Jul-Aug;11(4):260-268

Pontificia Universidad Javeriana, Department of Internal Medicine, School of Medicine - Bogota - Cundinamarca - Colombia.

Objective: Poor sleep patterns are common in undergraduates and may turn them prone to mood disorders, substance abuse and impaired academic performance. The aim of this study was to assess sleep disturbances among medical students, and whether associations with academic performance, depressive symptoms or substance use were present.

Methods: Cross-sectional study in which 544 medical students of the Pontificia Universidad Javeriana in Bogota, Colombia were included. Read More

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http://dx.doi.org/10.5935/1984-0063.20180041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361310PMC
February 2019
1 Read

Associations Between Sleep Quality, Sleep Architecture and Sleep Disordered Breathing and Memory After Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnea in the Apnea Positive Pressure Long-term Efficacy Study (APPLES).

Sleep Sci 2018 Jul-Aug;11(4):231-238

Stanford University, Sleep Clinic and Center for Human Sleep Research - Redwood City - CA - United States.

Objective: The role of sleep architecture in consolidation of memory has not been extensively investigated. In this study, the association of continuous positive airway pressure (CPAP) and sleep architecture and quality, and sleep disordered breathing on changes in memory are explored during the course of a 6 month clinical trial of CPAP or sham CPAP (APPLES).

Methods: 848 participants had polysomnographic and memory assessments (Buschke Selective Reminding Test [Buschke] and Digit Symbol Substitution Test [DSST]) at baseline, CPAP/Sham CPAP titration, and the 2 and 6 month time points. Read More

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http://dx.doi.org/10.5935/1984-0063.20180037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361302PMC
February 2019
1 Read

A case of positional central sleep apnea due to compression of the left vertebral artery on brainstem.

Sleep Sci 2018 Jul-Aug;11(4):211-214

Hypnos Instituto del Sueño, Sleep Medicine, Neurology - Lima - Lima - Peru.

Studies evaluating the association between Central Sleep Apnea (CSA) and positional sleep apnea are not commonly described and are barely understood. We report a case of a 51-year-old-male with moderate Obstructive Sleep Apnea (OSA) and severe CSA probably secondary to brainstem compression, which responded to the adoption of strict lateral body posture. The addition of Continuous Positive Airway Pressure (CPAP) optimally resolved the remaining obstructive respiratory events. Read More

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http://dx.doi.org/10.5935/1984-0063.20180034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361311PMC
February 2019
1 Read

Betatrophin association with serum triglyceride levels in obstructive sleep apnea patients.

Ann Thorac Med 2019 Jan-Mar;14(1):63-68

Department of Medical Biochemistry, Medical Faculty, Yuzuncu Yil University, Van, Turkey.

Background: Obstructive sleep apnea (OSA) is a common sleep problem, in which patients are at increased risk for metabolic and cardiovascular problems, including metabolic syndrome, diabetes mellitus (DM), and dyslipidemia. Betatrophin is a novel protein that regulates fatty acid and triglyceride (TG) metabolism and is related to obesity and metabolic abnormalities, including metabolic syndrome, DM, and dyslipidemia. Although OSA and betatrophin share common abnormalities, their relationship has not been investigated. Read More

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http://dx.doi.org/10.4103/atm.ATM_52_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341867PMC
February 2019
1 Read

The effect of nonbenzodiazepines sedative hypnotics on apnea-hypopnea index: A meta-analysis.

Ann Thorac Med 2019 Jan-Mar;14(1):49-55

Astria Health Center, Euclid, Grandview, Washington, USA.

Introduction: Nonbenzodiazepine (non-BZD) sedative hypnotics (NBSH) refer to non-BZD sedatives that act as BZD receptor agonists such as zolpidem, zaleplon, and eszopiclone. Today, there is a high prevalence of insomnia with or without concurrent obstructive sleep apnea (OSA). Our goal was to study how NBSH use impacts the baseline apnea-hypopnea index (AHI) in patients with or without OSA. Read More

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http://dx.doi.org/10.4103/atm.ATM_198_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341859PMC
February 2019
1 Read

A spirometric and cephalometric comparative evaluation of mandibular advancement devices and occlusal jig.

J Indian Prosthodont Soc 2019 Jan-Mar;19(1):66-73

Department of Prosthodontics, MGDCH, Jaipur, Rajasthan, India.

Aim: Aim of the current study was to evaluate the effect of occlusal jig with increased vertical dimension and mandibular advancement device on the oropharangeal volume in completely edentulous patients using spirometry and cephalometry.

Materials And Methods: The current study included includes 30 completely edentulous patient according to inclusion criteria. They were each subjected to cephalometric and spirometric analysis wearing CCD, OJ & MAD. Read More

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http://dx.doi.org/10.4103/jips.jips_94_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340075PMC
March 2018
1 Read

Causes of secondary hypertension from a single center in Northern Greece; a retrospective clinical study.

Folia Med Cracov 2018 ;58(4):35-45

Department of Internal Medicine, General Hospital of Veria, Veria, Greece.

Hypertension constitutes one of the most common diseases leading patients to the Outpatient Departments. Idiopathic hypertension is the prevailing type, but on the other hand, the possible presence of clinical entities responsible for the development of secondary hypertension should never be underestimated. We retrospectively studied 447 subjects aged between 20 and 84 years old and diagnosed with hypertension, who were thoroughly evaluated for secondary hypertension. Read More

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January 2018
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Assessment and treatment of pediatric obstructive sleep apnea in Canada: history and current state of affairs.

Authors:
Joanna E MacLean

Sleep Med 2019 Jan 23. Epub 2019 Jan 23.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Women & Children's Health Research Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada; Stollery Children's Hospital, Edmonton, Alberta, Canada. Electronic address:

Aim: To highlight Canada's contributions to the assessment and treatment of pediatric obstructive sleep apnea as well as outline the current state of pediatric obstructive sleep apnea in Canada.

Methods: A search was conducted in MEDLINE (Ovid) using Medical Subject Headings (MeSH) and free-text terms for 'child' and 'obstructive sleep apnea' with subsequent 'human' limit. The results were reviewed to identify publications where any author's listed a Canadian institution. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.011DOI Listing
January 2019
1 Read

Sleep-Disordered Breathing Is Associated With Recurrent Ischemic Stroke.

Stroke 2019 Feb 12:STROKEAHA118023807. Epub 2019 Feb 12.

From the Stroke Program, University of Michigan Medical School, University of Michigan, Ann Arbor (D.L.B., E.C., L.B.M., L.D.L.).

Background and Purpose- Limited data are available about the relationship between sleep-disordered breathing (SDB) and recurrent stroke and mortality, especially from population-based studies, large samples, or ethnically diverse populations. Methods- In the BASIC project (Brain Attack Surveillance in Corpus Christ), we identified patients with ischemic stroke (2010-2015). Subjects were offered screening for SDB with the ApneaLink Plus device, from which a respiratory event index (REI) ≥10 defined SDB. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023807DOI Listing
February 2019
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Outcomes of Children with Mild Obstructive Sleep Apnea Treated Nonsurgically: A Retrospective Review.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829019. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts, USA.

Objective: Obstructive sleep apnea (OSA) is characterized by partial or complete obstruction of the upper airway and is commonly caused by adenotonsillar hypertrophy in children. Accordingly, adenotonsillectomy is considered first-line treatment. However, in cases of mild OSA, nonsurgical management has been proposed as an alternative. Read More

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http://dx.doi.org/10.1177/0194599819829019DOI Listing
February 2019
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CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2019 EXECUTIVE SUMMARY.

Endocr Pract 2019 Jan;25(1):69-100

Abbreviations: A1C = hemoglobin A1C; AACE = American Association of Clinical Endocrinologists; ACCORD = Action to Control Cardiovascular Risk in Diabetes; ACCORD BP = Action to Control Cardiovascular Risk in Diabetes Blood Pressure; ACE = American College of Endocrinology; ACEI = angiotensin-converting enzyme inhibitor; AGI = alpha-glucosidase inhibitor; apo B = apolipoprotein B; ARB = angiotensin II receptor blocker; ASCVD = atherosclerotic cardiovascular disease; BAS = bile acid sequestrant; BMI = body mass index; BP = blood pressure; CCB = calcium channel blocker; CGM = continuous glucose monitoring; CHD = coronary heart disease; CKD = chronic kidney disease; DKA = diabetic ketoacidosis; DPP4 = dipeptidyl peptidase 4; eGFR = estimated glomerular filtration rate; EPA = eicosapentaenoic acid; ER = extended release; FDA = Food and Drug Administration; GLP1 = glucagon-like peptide 1; HDL-C = high-density-lipoprotein cholesterol; HeFH = heterozygous familial hypercholesterolemia; LDL-C = low-density-lipoprotein cholesterol; LDL-P = low-density-lipoprotein particle; Look AHEAD = Look Action for Health in Diabetes; NPH = neutral protamine Hagedorn; OSA = obstructive sleep apnea; PCSK9 = proprotein convertase subtilisin-kexin type 9 serine protease; RCT = randomized controlled trial; SU = sulfonylurea; SGLT2 = sodium-glucose cotransporter 2; SMBG = self-monitoring of blood glucose; T2D = type 2 diabetes; TZD = thiazolidinedione. Read More

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http://dx.doi.org/10.4158/CS-2018-0535DOI Listing
January 2019
1 Read