33,571 results match your criteria Obstructive Sleep Apnea


Subjects with venous insufficiency have high risk of obstructive sleep apnea in relationship to fluid shift.

Sleep Med 2020 Apr 10;72:135-137. Epub 2020 Apr 10.

Association des Médecins Vasculaires Hospitaliers, Service de Médecine Vasculaire CHU Montpellier, France.

Background: Obstructive sleep apnea (OSA) is highly prevalent in conditions characterized by fluid overload. Chronic venous insufficiency (CVI) is associated to fluid overload that might interfere with OSA occurrence and severity.

Methods: A total of 180 patients with symptomatic CVI completed the Berlin questionnaire and were assessed for the presence of symptoms and signs of OSA and fluid shift. Read More

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http://dx.doi.org/10.1016/j.sleep.2020.03.033DOI Listing

Recent advances in orthognathic surgery.

Curr Opin Otolaryngol Head Neck Surg 2020 Aug;28(4):246-250

Texas Center for Facial Plastic and Laser Surgery, San Antonio, Texas.

Purpose Of Review: The aim of this article is to review the recent literature on orthognathic surgery for treatment of malocclusion and obstructive sleep apnea (OSA). The discussion outlines the refinements of the procedure and advances in technology.

Recent Findings: Maxillomandibular advancement (MMA) may be performed for complex malocclusion and OSA. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000638DOI Listing

Cardiovascular and somatic comorbidities and sleep measures using three hypopnea criteria in mild obstructive sleep-disordered breathing: sex, age and body mass index differences in a retrospective sleep clinic cohort.

J Clin Sleep Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Medicine, Baystate Medical Center, University of Massachusetts Medical School -Baystate, Springfield, Massachusetts.

Study Objectives: To describe sex, age and body mass index (BMI) differences in comorbidities and polysomnography (PSG) measures, categorized using three different apnea-hypopnea index (AHI) criterion, in sleep clinic patients with mild obstructive sleep-disordered breathing (SDB).

Methods: A retrospective cohort of 305 (64% female) adult sleep clinic patients who underwent full night in-laboratory polysomnography diagnosed with mild SDB and prescribed positive airway pressure (PAP). Effects of sex, age and BMI on comorbidities and PSG measures including rates of AHI defined by ≥3% desaturations (AHI), with arousals (AHI), by ≥4% desaturations (AHI) and by respiratory disturbance index (RDI) were evaluated. Read More

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The dentist's role in diagnosis and treatment of obstructive sleep apnea syndrome: a literature review.

J Biol Regul Homeost Agents 2020 May-Jun;34(3 Suppl. 1):173-180

Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy.

The purpose of this work was to present a review of the literature concerning obstructive sleep apnea syndrome, and the role of the dentist in this pathology, both to identify elements useful for a good diagnosis and to apply the available therapeutic strategies. In literature there is no unanimous opinion on the treatment of OSAS. The multidisciplinary approach is necessary, creating teams made up of dentists, otolaryngologists and medical experts in sleep disorders, in order to develop a cooperation-based treatment plan for the disease. Read More

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Bruma MAD: a new way of treating OSAS patients.

J Biol Regul Homeost Agents 2020 May-Jun;34(3 Suppl. 1):165-171

Department of Orthodontics, School of Dentistry, University of Catania, Catania 95123, Italy.

The aim of this study was to introduce a new adjustable device in the treatment of obstructive sleep apnea syndrome (OSAS). The new appliance has a different way to regulate and move the mandible through the presence of two occlusal lifts, that can leave an open posterior space, and the complex system formed by the peduncle and the steel plate that can easily move forward the mandible. This system guarantees a posterior space for the tongue but mostly for the passage of air. Read More

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The dentist's role in diagnosis and treatment of obstructive sleep apnea syndrome: a literature review.

J Biol Regul Homeost Agents 2020 May-Jun;34(3 Suppl. 1):173-180

Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy.

The purpose of this work was to present a review of the literature concerning obstructive sleep apnea syndrome, and the role of the dentist in this pathology, both to identify elements useful for a good diagnosis and to apply the available therapeutic strategies. In literature there is no unanimous opinion on the treatment of OSAS. The multidisciplinary approach is necessary, creating teams made up of dentists, otolaryngologists and medical experts in sleep disorders, in order to develop a cooperation-based treatment plan for the disease. Read More

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Hypercapnia at Hospital Admission as a Predictor of Mortality.

Open Access Emerg Med 2020 26;12:173-180. Epub 2020 Jun 26.

Marienkrankenhaus Kassel, Kassel, Germany.

Introduction: Hypercapnia is an indicator of ventilatory exhaustion. There is some disagreement regarding whether hypercapnia is also a predictor of mortality. In this prospective study, we aimed to investigate whether hypercapnia can predict in-hospital and 1-year mortality rates in patients with dyspnea or pulmonary diseases. Read More

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http://dx.doi.org/10.2147/OAEM.S242075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326210PMC

Examination of the Relationship Between Metabolic Syndrome and Obstructive Sleep Apnea in Iranian Patients with Type 2 Diabetes: A Case-Control Study.

Diabetes Metab Syndr Obes 2020 26;13:2251-2257. Epub 2020 Jun 26.

Clinical Care Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Introduction: Obstructive sleep apnea (OSA) is a common risk factor for metabolic syndrome (MS) that increases the chance of cardiovascular disease, stroke, and mortality. Many studies have been conducted on this matter, but the results are still conflicting. The aim of the present study was to examine the relationship between metabolic syndrome (MS) and obstructive sleep apnea (OSA) in Iranian patients with type 2 diabetes (T2D). Read More

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http://dx.doi.org/10.2147/DMSO.S260677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326211PMC

Association between the neutrophil-to-lymphocyte ratio and obstructive sleep apnea: a meta-analysis.

Sci Rep 2020 Jul 2;10(1):10862. Epub 2020 Jul 2.

Department of Otorhinolaryngology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

This meta-analysis is aimed to investigate the association between the neutrophil-to-lymphocyte ratio (NLR) and obstructive sleep apnea (OSA). The PubMed, Web of Science, Google Scholar, and Cochrane Library databases were searched to collect all relevant articles. The pooled standardized mean difference (SMD) with a 95% confidence interval (CI) was calculated using the random effects model. Read More

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http://dx.doi.org/10.1038/s41598-020-67708-wDOI Listing

Cell-Autonomous Autophagy Protects Against Chronic Intermittent Hypoxia Induced Sensory Nerves and Endothelial Dysfunction of the Soft Palate.

Med Sci Monit 2020 Jul 3;26:e920878. Epub 2020 Jul 3.

Ear, Nose, and Throat (ENT) Department, Tongren Hospital, Shanghai, China (mainland).

BACKGROUND Chronic intermittent hypoxia (CIH) is a key feature of obstructive sleep apnea (OSA) syndrome. The pathogenesis of CIH-induced soft palate lesion is not well understood. Understanding the mechanisms of CIH-induced soft palate damage could provide new strategies for clinical treatment. Read More

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http://dx.doi.org/10.12659/MSM.920878DOI Listing

Inflammation in children with neuromuscular disorders and sleep disordered breathing.

Sleep Med 2020 Apr 9;72:118-121. Epub 2020 Apr 9.

Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK.

Introduction: Paediatric obstructive sleep apnoea is associated with systemic inflammation and co-morbidities. We assessed whether sleep disordered breathing (SDB) due to neuromuscular weakness was associated with elevated airway and systemic pro-inflammatory cytokines.

Methods: Consecutive neuromuscular children (age 5-18years) underwent overnight full polysomnography and morning collection of serum and breath condensate, analysed for cytokines (Interleukin-10, Interleukin-6, Interleukin-1β, Tumour Necrosis Factorα, high-sensitivity C-Reactive Protein, Intercellular and Vascular Adhesion Molecules ICAM-1, VCAM-1). Read More

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http://dx.doi.org/10.1016/j.sleep.2020.03.032DOI Listing

Knowledge and attitude of primary care physicians towards obstructive sleep apnea in the Middle East and North Africa region.

Sleep Breath 2020 Jul 1. Epub 2020 Jul 1.

Department of Family Medicine, American University of Beirut Medical Center, Riad El-Solh, Beirut, 1107 2020, Lebanon.

Background/objectives: Sleep disorders are highly prevalent in primary care. Obstructive sleep apnea (OSA) is one of the most common sleep disorders in the world, and it is estimated that only 10 to 20% of OSA cases are diagnosed. Primary care physicians (PCP) play an important role in screening for OSA. Read More

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http://dx.doi.org/10.1007/s11325-020-02137-7DOI Listing

Approach and Management of Hypertension After Kidney Transplantation.

Front Med (Lausanne) 2020 16;7:229. Epub 2020 Jun 16.

Department of Medicine, University of California Irvine School of Medicine, Orange, CA, United States.

Hypertension is one of the most common cardiovascular co-morbidities after successful kidney transplantation. It commonly occurs in patients with other metabolic diseases, such as diabetes mellitus, hyperlipidemia, and obesity. The pathogenesis of post-transplant hypertension is complex and is a result of the interplay between immunological and non-immunological factors. Read More

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http://dx.doi.org/10.3389/fmed.2020.00229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310511PMC

Auditory Function of Patients with Obstructive Sleep Apnea Syndrome: A Study.

Eurasian J Med 2020 Jun 4;52(2):176-179. Epub 2020 Jun 4.

Department of Otorhinolaryngology, Ataturk University School of Medicine, Erzurum, Turkey.

Objective: Obstructive sleep apnea syndrome (OSAS) is a respiratory syndrome that manifests during sleep. For the auditory system to be able to function normally, the inner ear and cochlear nerve require healthy oxygen support. The purpose of this study was to assess the hearing function of patients with OSAS and to reveal the relationship between polysomnographic parameters and hearing test results. Read More

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http://dx.doi.org/10.5152/eurasianjmed.2019.18373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311141PMC

Current Status of Diagnosis and Management of Functioning Pituitary Tumors: Part II.

Neurol India 2020 May-Jun;68(Supplement):S20-S27

Department of Endocrinology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.

Functioning pituitary tumors contribute to significant morbidity and mortality. Proper diagnostic approach and management is essential for optimal outcomes. Prolactinomas, the commonest of these, are the only tumors which can be managed medically. Read More

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http://dx.doi.org/10.4103/0028-3886.287672DOI Listing

Differences in Anthropometric and Clinical Features among Preschoolers, School-Age Children, and Adolescents with Obstructive Sleep Apnea-A Hospital-Based Study in Taiwan.

Int J Environ Res Public Health 2020 Jun 29;17(13). Epub 2020 Jun 29.

Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan.

Pediatric obstructive sleep apnea (OSA) is associated with adverse health outcomes; however, little is known about the diversity of this population. This retrospective study aims to investigate age-related differences in the anthropometric and clinical features of this population. A total of 253 Taiwanese children (70 (27. Read More

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http://dx.doi.org/10.3390/ijerph17134663DOI Listing

[Research progress on the predictive factors for the outcomes of adenotonsillectomy in children with obstructive sleep apnea syndrome].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Jun;55(6):630-634

Department of Respiratory, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

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http://dx.doi.org/10.3760/cma.j.cn115330-20191105-00666DOI Listing

A Cross-Sectional Comparison of the Prevalence of Obstructive Sleep Apnea Symptoms in Adults With Down Syndrome in Scotland and Japan.

Am J Intellect Dev Disabil 2020 Jul;125(4):260-273

Kyushu University Hospital, Fukuoka, Japan.

Small studies in Western populations report a high prevalence of obstructive sleep apnea (OSA) in adults with Down syndrome. To date, ethnic differences have not been explored. A questionnaire sent to 2,752 adults with Down syndrome aged ≥16 years in Scotland and Japan (789 valid responses) estimated OSA prevalence based on reported symptoms. Read More

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http://dx.doi.org/10.1352/1944-7558-125.4.260DOI Listing

Chronic toxoplasmosis and sleepiness in obstructive sleep apnea: Is there a link?

PLoS One 2020 1;15(7):e0235463. Epub 2020 Jul 1.

Inserm, CHU Grenoble Alpes, HP2, University Grenoble Alpes, Grenoble, France.

Introduction: Sleepiness is the main clinical expression of obstructive sleep apnea (OSA) syndrome resulting from upper airway collapse. Recent studies have discussed the fact that the presence of T. gondii cysts in the brain and the resulting biochemical and immunological mechanisms could be linked to neurobehavioral disorders. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235463PLOS

Diagnostic Value of Sestrin2 in Patients with Obstructive Sleep Apnea.

Metab Syndr Relat Disord 2020 Jun 29. Epub 2020 Jun 29.

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Obstructive sleep apnea (OSA) is a serious threat to individual health. Diagnosis of OSA is mainly polysomnography (PSG). However, PSG monitoring is costly and time-consuming. Read More

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http://dx.doi.org/10.1089/met.2020.0018DOI Listing

Does Nasal Obstruction Induce Obstructive Sleep Apnea in Healthy Women?

Nat Sci Sleep 2020 22;12:347-355. Epub 2020 Jun 22.

Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.

Purpose: Obstructive sleep apnea (OSA) is less prevalent among women and is associated with different symptoms and consequences to OSA in men. The reasons for these differences are unknown and difficult to tease apart in clinical populations. If OSA could be temporarily induced in healthy men and women, the causes of some of these differences could be investigated. Read More

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http://dx.doi.org/10.2147/NSS.S254473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319502PMC

Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study.

Nat Sci Sleep 2020 8;12:333-345. Epub 2020 Jun 8.

Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, People's Republic of China.

Objective: Patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) exhibit neurocognitive impairments; however, the neuroimaging mechanism of neurocognitive impairments remains unclear. The aim of this study was to understand the neuroimaging mechanism in adult patients with moderate-to-severe OSAHS, from the perspective of the connectome.

Patients And Methods: Thirty-one untreated patients with moderate-to-severe OSAHS (mean age: 41. Read More

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http://dx.doi.org/10.2147/NSS.S248643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293417PMC

The efficacy of different treatment approaches for pediatric OSAHS patients with mandibular retrognathia: study protocol for a multicenter randomized controlled trial.

Trials 2020 Jun 30;21(1):595. Epub 2020 Jun 30.

Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University, Shanghai, China.

Background: Pediatric obstructive sleep apnea/hypopnea syndrome (OSAHS) is a multifactorial syndrome caused by many risk factors, such as craniofacial anomalies, adenotonsillar hypertrophy, obesity, and airway inflammation. Although new treatment patterns have recently been proposed, treatment methods for children remain particularly challenging and controversial. This randomized controlled trial was designed to investigate the efficacy of adenotonsillectomy and/or orthodontic treatment for children who have mild OSAHS with mandibular retrognathia. Read More

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http://dx.doi.org/10.1186/s13063-020-04398-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329444PMC

Obstructive Sleep Apnea: A Prediction Model Using Supervised Machine Learning Method.

Stud Health Technol Inform 2020 Jun;272:387-390

Department of Community Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Obstructive Sleep Apnea (OSA) is the most common breathing-related sleep disorder, leading to increased risk of health problems. In this study, we investigated and evaluated the supervised machine learning methods to predict OSA. We used popular machine learning algorithms to develop the prediction models, using a dataset with non-invasive features containing 231 records. Read More

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http://dx.doi.org/10.3233/SHTI200576DOI Listing

Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies.

Sleep Med Rev 2020 May 16;53:101339. Epub 2020 May 16.

The University of Sydney, Faculty of Science, School of Psychology, Sydney, New South Wales, Australia; Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Camperdown, New South Wales, Australia; The University of Sydney, Brain and Mind Centre, Sydney, New South Wales, Australia. Electronic address:

Cannabinoids, including the two main phytocannabinoids Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), are being increasingly utilised as pharmacological interventions for sleep disorders. THC and CBD are known to interact with the endocannabinoid and other neurochemical systems to influence anxiety, mood, autonomic function, and circadian sleep/wake cycle. However, their therapeutic efficacy and safety as treatments for sleep disorders are unclear. Read More

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http://dx.doi.org/10.1016/j.smrv.2020.101339DOI Listing

Intranasal Leptin Prevents Opioid Induced Sleep Disordered Breathing in Obese Mice.

Am J Respir Cell Mol Biol 2020 Jun 30. Epub 2020 Jun 30.

Johns Hopkins University, 1466, Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States.

Respiratory depression is the main cause of morbidity and mortality associated with opioids. Obesity increases opioid-related mortality, which is mostly related to co-morbid obstructive sleep apnea. Naloxone, a μ-opioid receptor blocker, is an effective antidote, but it reverses analgesia. Read More

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http://dx.doi.org/10.1165/rcmb.2020-0117OCDOI Listing

Bariatric surgery outcomes: is age just a number?

Surg Endosc 2020 Jun 29. Epub 2020 Jun 29.

Section of Minimally Invasive and Bariatric Surgery, Department of Surgery, Indiana University School of Medicine Indiana, 11725 N Illinois St, Suite 350, Carmel, Indianapolis, IN, 46032, USA.

Introduction: Obesity and its associated comorbidities represent a pervasive problem in the United States across all age groups. There are conflicting data regarding the effectiveness and postoperative recovery of bariatric surgery in elderly patients. The aim of this study was to compare outcomes of bariatric surgery across age groups. Read More

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http://dx.doi.org/10.1007/s00464-020-07752-9DOI Listing

Prevalence of obstructive sleep apnea in female patients with fibromyalgia.

Saudi Med J 2020 Jul;41(7):740-745

Department of Chest Diseases, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. E-mail.

Objectives: To determine the prevalence of obstructive sleep apnea in female patients with fibromyalgia (FM)presenting to physical therapy outpatient clinics.

Methods: The 36-item short form health survey (SF-36) questionnaire, Berlin test, and epworth sleepiness scale were administered, along with a polysomnography to 38 female patients. This cross-sectional study comprised diagnosed with FM according to the diagnostic criteria of the American College of Rheumatology, between March 2017 and August 2019, at the Faculty of Medicine Hospital, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. Read More

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http://dx.doi.org/10.15537/smj.2020.7.25165DOI Listing

Transferrin saturation is independently associated with the severity of obstructive sleep apnea syndrome and hypoxia among obese subjects.

Clin Nutr 2020 Jun 17. Epub 2020 Jun 17.

Unité de Nutrition, Service d'Endocrinologie-Diabétologie-Nutrition, CHU Rennes, Rennes, France; INRAE, INSERM, Univ Rennes, Nutrition Metabolisms and Cancer, NuMeCan, Rennes, France. Electronic address:

Introduction & Aims: Obstructive sleep apnea syndrome (OSAS) is a frequent complication of obesity. Intermittent chronic hypoxia which frequently results from OSAS could modulate the systemic control of iron metabolism and alter serum iron parameters, especially among obese patients.

Aims: to evaluate whether serum parameters of iron bioavailability and storage (primary), as well as age, waist circumference, arterial hypertension and tobacco use (secondary) are associated with OSAS severity and/or hypoxia. Read More

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http://dx.doi.org/10.1016/j.clnu.2020.06.007DOI Listing

Human model of obstructive sleep apnea: how incomplete is it?

Authors:
Matiram Pun

J Appl Physiol (1985) 2020 Jul;129(1):47

Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1152/japplphysiol.00360.2020DOI Listing

Computer-Assisted Quantitative Analysis of Drug-Induced Sleep Endoscopy for Obstructive Sleep Apnea/Hypopnea Syndrome.

Otolaryngol Head Neck Surg 2020 Jun 30:194599820933206. Epub 2020 Jun 30.

Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Objectives: To use computer-assisted quantitative measurements of upper airway changes during drug-induced sleep endoscopy (DISE) and to correlate these parameters with disease severities and physiologic changes in patients with obstructive sleep apnea/hypopnea syndrome (OSA).

Design: A retrospective study.

Setting: Tertiary academic medical center. Read More

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http://dx.doi.org/10.1177/0194599820933206DOI Listing
June 2020
1.721 Impact Factor

[Clinical profile of patients with obstructive sleep apnea syndrome in a cardiology hospital].

Ter Arkh 2020 May 19;92(4):9-16. Epub 2020 May 19.

National Medical Research Center for Cardiology.

Relevance: Obstructive sleep apnea syndrome (OSAS) is an important medical and social problem due to its high prevalence and impact on quality of life. The relationship between OSAS and cardiovascular pathology has been proven by many studies, which confirms the necessity for early diagnosis of OSAS and its treatment for the prevention of fatal and non-fatal events.

Aim: to study epidemiological and clinical profile of the patients referred by a cardiologist to a specialized sleep laboratory to verify the diagnosis of OSAS. Read More

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http://dx.doi.org/10.26442/00403660.2020.04.000553DOI Listing

[Lipid status and oxidative stress in menopausal women with obstructive apnea syndrome].

Ter Arkh 2019 Oct 15;91(10):48-53. Epub 2019 Oct 15.

Scientific Centre for Family Health and Human Reproduction Problems.

Aim: to assess lipid profile, lipid peroxidation and antioxidant system parameters in peri - and postmenopausal women with obstructive sleep apnea syndrome (OSAS).

Materials And Methods: 37 perimenopausal women and 43 postmenopausal ones were examined. OSAS diagnosis was made on the basis of the clinical picture and the polysomnography results. Read More

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http://dx.doi.org/10.26442/00403660.2019.10.000050DOI Listing
October 2019

Vertical dimension in dental sleep medicine oral appliance therapy.

Gen Dent 2020 Jul-Aug;68(4):69-76

The objective of this pilot study was to evaluate the effect of a multidimensional approach to occlusal registration, including vertical dimension as assessed using pharyngometry, on the success of oral appliance therapy. Successful medical improvements resulting from therapy were determined by secondary polysomnographic studies. Thirty patients were enrolled in this pilot study. Read More

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Evaluation of the changes in the hearing system over the years among patients with OSAS using a CPAP device.

Cranio 2020 Jun 28:1-4. Epub 2020 Jun 28.

Department of Otorhinolaryngology, Head and Neck Surgery, Namık Kemal University , Tekirdağ, Turkey.

Objective: To evaluate whether patients using a continuous positive airway pressure (CPAP) device for obstructive sleep apnea syndrome (OSAS) have improvement or deterioration in their auditory systems.

Methods: Charts of OSAS patients who were followed up at the ENT clinic were retrospectively reviewed starting from 2018. The hearing tests performed at least 2 years before and after CPAP use in patients were compared with themselves and with the test results of patients with no CPAP use. Read More

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http://dx.doi.org/10.1080/08869634.2020.1783050DOI Listing

Potential Cytochrome P450 Drug-Drug Interaction Among Adult and Adolescent Patients Undergoing Tonsillectomy.

OTO Open 2020 Apr-Jun;4(2):2473974X20932503. Epub 2020 Jun 18.

University of Rochester, Rochester, New York, USA.

Objective: To assess the frequency of potential drug-drug interactions affecting cytochrome P450 (CYP)-mediated metabolism of opioids among adult and adolescent patients who underwent adenotonsillectomy.

Study Design: Retrospective chart review.

Setting: Tertiary care university hospital. Read More

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http://dx.doi.org/10.1177/2473974X20932503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303781PMC

Craniofacial, dental arch morphology, and characteristics in preschool children with mild obstructive sleep apnea.

J Dent Sci 2020 Jun 9;15(2):193-199. Epub 2019 Nov 9.

Department of Pediatric Dentistry, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Background/purpose: Pediatric obstructive sleep apnea (OSA) might be a serious cause of neurocognitive deficits, behavioral changes, and craniofacial disharmony in children at very young age with mild type of OSA. This study aims to examine the effect of mild OSA on craniofacial morphology as well as dental arch morphology and characteristics in preschool children.

Materials And Methods: The test group comprised 16 preschool children (11 boys, 5 girls; mean age: 5. Read More

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http://dx.doi.org/10.1016/j.jds.2019.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305443PMC

The impact of positive airway pressure on midface growth: a literature review.

Braz J Otorhinolaryngol 2020 Jun 15. Epub 2020 Jun 15.

Universidade Federal de São Paulo (Unifesp), Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.

Introduction: The treatment of obstructive sleep apnea with positive airway pressure in children is restricted due to concerns that it could affect maxilla growth over time.

Objective: To undertake a systematic review of the literature about the long-term impact of using a positive airway pressure mask on the midface in growing individuals.

Methods: The literature search was conducted in September 2019 using the keywords ("long-term" OR "long term" OR "side effects" OR longitudinal) AND (children OR child OR preschool OR adolescents OR adolescent OR infant OR infants) AND (craniofacial OR "mid-face" OR midface OR midfacial OR facial OR maxillary) AND ("airway pressure" OR ventilation) in the databases PubMed, Web of Science and Lilacs. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.05.010DOI Listing

Clarifying the role of sleep in depression: A narrative review.

Psychiatry Res 2020 Jun 16;291:113239. Epub 2020 Jun 16.

Department of Medicine, University of South Carolina, Columbia, SC, United States; Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, SC, United States.

It has been established that 4.4 to 20% of the general population suffers from a major depressive disorder (MDD), which is frequently associated with a dysregulation of normal sleep-wake mechanisms. Disturbances of circadian rhythms are a cardinal feature of psychiatric dysfunctions, including MDD, which tends to indicate that biological clocks may play a role in their pathophysiology. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113239DOI Listing

Neuroendocrine abnormalities associated with untreated first episode patients of major depressive disorder with comorbid obstructive sleep apnea.

Psychiatry Res 2020 Jun 22;291:113248. Epub 2020 Jun 22.

Department of Psychiatry, The second Affiliated Hospital of Kunming Medical University, DianMian Road 374, Kunming Yunnan 650101, China. Electronic address:

There are few studies that explore the relationship of neuroendocrine hormones of the HPA, HPT and HPG axes with major depressive disorder (MDD) with comorbid obstructive sleep apnea (OSA). The aim of this study is to examine neuroendocrine abnormalities and the relationship in untreated first episode patients of MDD comorbided with OSA. Polysomnography, neuroendocrine hormones were determined for 111 patients. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113248DOI Listing

IN-HOSPITAL MANAGEMENT OF SLEEP APNEA DURING HEART FAILURE HOSPITALIZATION- A RANDOMIZED CONTROLLED TRIAL.

J Card Fail 2020 Jun 24. Epub 2020 Jun 24.

The Sleep Heart Program at the Ohio State University; Division of Cardiovascular Medicine, The Ohio State University; The Center for Biostatistics, The Ohio State University.

Background: Obstructive sleep apnea (OSA) is associated with increased mortality and readmissions in patients with heart failure (HF). The effect of in-hospital diagnosis and treatment of OSA during decompensated HF episodes remains unknown.

Methods: A single site randomized controlled trial in hospitalized patients with decompensated HF (n=150) who were diagnosed with OSA during the hospitalization. Read More

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http://dx.doi.org/10.1016/j.cardfail.2020.06.007DOI Listing

Functional Organization of the Insula in Men and Women with Obstructive Sleep Apnea during Valsalva.

Sleep 2020 Jun 27. Epub 2020 Jun 27.

UCLA School of Nursing, University of California, Los Angeles, California, United States of America.

Study Objectives: Obstructive sleep apnea (OSA) patients show impaired autonomic regulation, perhaps related to functional reorganization of the insula, which in healthy individuals shows sex-specific anterior and right-dominance during sympathetic activation. We examined insular organization of responses to a Valsalva maneuver in OSA with functional magnetic resonance imaging (fMRI).

Methods: We studied 43 newly-diagnosed OSA (age mean±std:46. Read More

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http://dx.doi.org/10.1093/sleep/zsaa124DOI Listing

Clinical features and risk factors in patients with asthma complicated with obstructive sleep apnea-hypopnea syndrome: a hospital-based study.

Sleep Breath 2020 Jun 27. Epub 2020 Jun 27.

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongti South Road, Chaoyang District, Beijing, 100020, China.

Purpose: The current study was conducted to explore the clinical features and risk factors of patients with asthma complicated by obstructive sleep apnea-hypopnea syndrome (OSAHS).

Methods: Patients with asthma who underwent polysomnography in our hospital from August 2017 to December 2019 were enrolled in the study. Data on demographics, pulmonary function testing, polysomnography, blood gases, mean pulmonary artery pressure, and vascular endothelial growth factor (VEGF) were compared between the two groups. Read More

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http://dx.doi.org/10.1007/s11325-020-02127-9DOI Listing

Safety and effectiveness in explantation and re-implantation of hypoglossal nerve stimulation devices.

Eur Arch Otorhinolaryngol 2020 Jun 26. Epub 2020 Jun 26.

Department of Otorhinolaryngology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.

Purpose: Since 2001, hypoglossal nerve stimulators have been implanted in patients with obstructive sleep apnea around the world, initially in trial situations but more recently also in regular care settings. Medium term data indicate effectiveness and tolerability of treatment. However, when assessing the safety of the procedure, the safe feasibility of explantation or reimplantation must also be considered. Read More

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http://dx.doi.org/10.1007/s00405-020-06170-wDOI Listing

Cardiovascular Outcomes Post Percutaneous Coronary Intervention in Patients with Obstructive Sleep Apnea and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Diabetes Ther 2020 Jun 26. Epub 2020 Jun 26.

Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.

Introduction: Type 2 diabetes mellitus (T2DM) is a major risk factor for the occurrence of cardiovascular diseases. Similar to T2DM, obstructive sleep apnea (OSA) is also known to be a risk factor for cardiovascular diseases. In this analysis, we aimed to systematically compare the post-interventional cardiovascular outcomes observed in patients with T2DM with versus without OSA. Read More

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http://dx.doi.org/10.1007/s13300-020-00870-6DOI Listing

Obstructive Sleep Apnea, Other Sleep Characteristics, and Risk of CKD in the Atherosclerosis Risk in Communities Sleep Heart Health Study.

J Am Soc Nephrol 2020 Jun 26. Epub 2020 Jun 26.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.

Background: Obstructive sleep apnea may be associated with development of CKD through hypoxia, inflammation, and oxidative stress. Individuals with this sleep disorder are also at increased risk for established CKD risk factors, including obesity, hypertension, and type 2 diabetes.

Methods: We examined the association between obstructive sleep apnea, other sleep characteristics, and risk of incident CKD (stage 3 or higher) in 1525 participants (mean age, 62. Read More

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http://dx.doi.org/10.1681/ASN.2020010024DOI Listing

Obstructive sleep apnea and pulmonary hypertension: a bidirectional relationship.

J Clin Sleep Med 2020 Jun 26. Epub 2020 Jun 26.

Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California.

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Obstructive Sleep Apnea Risk and Stroke among Blacks with Metabolic Syndrome: Results from Metabolic Syndrome Outcome (MetSO) Registry.

Int J Clin Res Trials 2020 26;5(1). Epub 2020 Feb 26.

Center for Healthful Behavior Change (CHBC), Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.

Introduction: The American Stroke Association estimates that stroke is the fifth leading cause of death in the United States. According to the Center for Disease Control and Prevention someone in the United States has a stoke every 40 seconds, affecting more than 795,000 people of which 140,000 result in death [1]. Emerging evidence suggests that obstructive sleep apnea (OSA) is a strong risk factor for stroke. Read More

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http://dx.doi.org/10.15344/2456-8007/2020/143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316191PMC
February 2020