Search Our Scientific Publications & Authors

J Stomatol Oral Maxillofac Surg 2021 Jun 9. Epub 2021 Jun 9.

Professor, Chief of the Service de Stomatologie et de Chirurgie Maxillo-faciale de la Pitié Salpétrière (France).

Objective: This pilot randomized crossover study evaluated the outcomes of two custom-made mandibular retention devices (MRDs), a computer-aided design (CAD)/computer-aided manufacturing (CAM) device (Narval CC™) and a non-CAD/CAM device (Narval™), on oropharyngeal airway volume in patients with obstructive sleep apnoea (OSA).

Methods: 12 OSA patients were recruited from an University Hospital for MRD therapy with either CAD/CAM or non-CAD/CAM first. A cone-beam computed tomography evaluation (CBCT) and polysomnography assessment was performed during baseline assessment and at the end of each study period. Read More

Laryngoscope 2021 Jun 12. Epub 2021 Jun 12.

Department of Plastic and Craniofacial Surgery, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Objectives/hypothesis: Robin sequence (RS) consists of associated micrognathia, glossoptosis, and respiratory dysfunction, with or without cleft palate. Studies on how different patient characteristics impact the severity of respiratory dysfunction are scarce and contradictory; this study investigates how different features affect respiratory obstruction severity at diagnosis of RS in controlled analysis.

Study Design: Retrospective cohort study that enrolled 71 RS patients under 90 days old who received care in our institution from 2009 to 2020. Read More

J Orthop Surg Res 2021 Jun 11;16(1):376. Epub 2021 Jun 11.

Department of Orthopedic, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 Litang Road, Dongxiaokou Town, Changping District, Beijing, 102218, China.

Background: The interscalene brachial plexus block (ISB) is a commonly used nerve block technique for postoperative analgesia in patients undergoing shoulder arthroscopy surgery; however, it is associated with potentially serious complications. The use of suprascapular nerve block (SSNB) has been described as an alternative strategy with fewer reported side effects for shoulder arthroscopy. This review aimed to compare the impact of SSNB and ISB during shoulder arthroscopy surgery. Read More

BMC Womens Health 2021 Jun 11;21(1):239. Epub 2021 Jun 11.

Medical Imaging College, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.

Background: Obstructive sleep apnea (OSA) is a sleep-related disorder with breathing difficulties. Previous studies revealed that epicardial fat thickness (EFT) correlates with OSA severity. Interestingly, female patients display a stronger EFT-OSA correlation than males. Read More

Physiol Meas 2021 Jun 11. Epub 2021 Jun 11.

Biomedical Engineering, TOBB Ekonomi ve Teknoloji Universitesi, Sogutozu Cad. No:43, Cankaya, 06560, TURKEY.

Objective: In this study, we conducted a comparative analysis of deep convolutional neural network (CNN) models in predicting Obstructive Sleep Apnea (OSA) using electrocardiograms. Unlike other studies in the literature, this study automatically extracts time-frequency features by using CNNs instead of manual feature extraction from ECG recordings.

Approach: The proposed model generates scalogram and spectrogram representations by transforming preprocessed 30-sec ECG segments from time domain to the frequency domain using Continuous Wavelet Transform (CWT) and Short Time Fourier transform (STFT), respectively. Read More

PLoS One 2021 11;16(6):e0252844. Epub 2021 Jun 11.

Sleep Centre, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Background: In recent population-based case-control studies, sleep apnea was significantly associated with a higher incidence (hazard ratio, 1.71) of vertigo and the risk of tinnitus was found to increase 1.36 times in patients with sleep apnea. Read More

JMIR Res Protoc 2021 Jun 11. Epub 2021 Jun 11.

Department Otorhinolaryngology. Hospital Universitario Sanitas la Zarzuela, Madrid, ES.

Background: Myofunctional therapy is currently a reasonable therapeutic option to treat obstructive sleep apnea-hypopnea syndrome (OSAHS). This therapy is based on performing regular exercises of the upper airway muscles to increase their tone and prevent their collapse. Over the past decade there has been an increasing number of publications in this area; however, to our knowledge, there are no studies focused on the patients who can most benefit from this therapy. Read More

Immunopharmacol Immunotoxicol 2021 Jun 11:1-9. Epub 2021 Jun 11.

The First Clinical Medical College, Lanzhou University, Lanzhou, China.

Hypoxia-induced injury is a classic symptom of obstructive sleep apnea hypopnea syndrome (OSAHS), which is a risk factor of various diseases, such as hypertension, heart failure and stroke. However, there is no effective therapy for hypoxia-induced injury or OSAHS due to the elusive mechanism involved. This study aimed to assess the effects of paeoniflorin on hypoxia-induced injury and explore the underlying mechanism. Read More

Heart Rhythm O2 2020 Apr 27;1(1):10-13. Epub 2020 Apr 27.

Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York.

Background: Various methods have been implemented for screening of patients for atrial fibrillation (AF), but the yield has generally been low. Targeting high-risk patients may improve detection of asymptomatic AF, which could be of value if appropriate treatment could be initiated before a potential thromboembolic event.

Objective: The purpose of this study was to test screening of high-risk nursing home residents having ≥2 risk factors for AF and no previous history of AF using a smartphone-based electrocardiographic (ECG) monitoring device to determine whether it is an accurate, easy-to-use method of screening for asymptomatic AF. Read More

Nat Sci Sleep 2021 4;13:739-749. Epub 2021 Jun 4.

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.

Objective: Slow-wave sleep (SWS) and obstructive sleep apnea (OSA) have attracted recent research attention. However, their joint effects on insulin resistance (IR) remain unclear. This study explored whether SWS influences the relationship between OSA and IR. Read More

J Plast Reconstr Aesthet Surg 2021 Mar 28. Epub 2021 Mar 28.

Department of Plastic Surgery, Sophia Children's Hospital - Erasmus Medical Center, Rotterdam, Netherlands.

Introduction: Obstructive sleep apnea (OSA) is frequently present in patients with syndromic craniosynostosis. The aim of this study is to determine the long-term effectiveness of our OSA treatment protocol in our tertiary center in a cohort of children with syndromic craniosynostosis.

Methods: Children with syndromic craniosynostosis born between January 2005 and December 2013 were eligible for inclusion (n = 114). Read More

Auris Nasus Larynx 2021 Jun 7. Epub 2021 Jun 7.

School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8523, Japan. Electronic address:

Objective: Our aim was to investigate association between OSA and radiotherapy in head and neck cancer patients.

Methods: On 9th of September 2018, we have searched 12 electronic databases to retrieve relevant studies. All eligible studies that assessed association between OSA and radiotherapy in head and neck cancer patients were included in our meta-analysis. Read More

Sleep Med 2021 May 26;84:63-72. Epub 2021 May 26.

Grupo de Enfermedades Respiratorias, Servicio de Neumologia, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain; Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address:

Objectives/background: Little information is available about the association of obstructive sleep apnea (OSA) with atherogenic dyslipidemia and the contribution of sleep characteristics to lipid alterations. We compare dyslipidemia prevalence among non-apneic subjects and mild-severe OSA patients to identify the sleep characteristics that are independently associated with dyslipidemia and serum lipid levels in OSA patients.

Patients/methods: We recruited 809 consecutive patients who had been referred for polysomnography study by OSA suspicion. Read More

Life Sci 2021 Jun 7:119702. Epub 2021 Jun 7.

Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, United States; Department of Psychiatry, William S. Middleton Memorial Veterans Hospital, Madison, WI, United States.

Aims: Nearly a third of U.S. veterans who deployed in support of the 1990-1991 Persian Gulf War are affected by Gulf War illness (GWI). Read More

Ir J Med Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Disease Prevention and Control, Chinese PLA General Hospital, The 1st Medical Center, Beijing, 100853, China.

Background: To determine if alcohol consumption is a risk factor for obstructive sleep apnea (OSA) and nocturnal oxygen desaturation.

Methods: This case-control study evaluated patients with confirmed OSA and a control group using polysomnography (PSG). Two doctors who have worked in this field for more than 5 years provided a blinded interpretation of the patients' monitoring results. Read More

Eur Heart J Case Rep 2021 May 8;5(5):ytab174. Epub 2021 May 8.

Department of Cardiology, Pennsylvania Hospital-University of Pennsylvania Health System, 800 Spruce Street, Philadelphia, PA, USA.

Background: Effusive-constrictive pericarditis (ECP) is a rare syndrome involving pericardial effusion and concomitant constrictive pericarditis. The hallmark is a persistently elevated right atrial pressure of >10 mmHg or reduction of less than 50% from baseline despite pericardiocentesis. Aetiologies include radiation, infection, malignancy, and autoimmune disease. Read More

BMJ Open Respir Res 2021 Jun;8(1)

Public Health Sciences, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA

Objectives: Over 1 billion individuals worldwide experience some form of sleep apnoea, and this number is steadily rising. Obstructive sleep apnoea (OSA) can negatively influence one's quality of life and potentially increase mortality risk. However, the association between OSA and mortality has not been reliably estimated. Read More

Auris Nasus Larynx 2021 Jun 6. Epub 2021 Jun 6.

Department of Otorhinolaryngology, Head and Neck Surgery, Juntendo University School of Medicine, Tokyo, Japan.

Concurrent chemoradiotherapy (CCRT) is one of the most promising treatments for advanced head and neck cancer (HNC). On the other hand, CCRT may induce severe edema in laryngo-pharyngeal structures in association with radiation. This is a report of a 66-year-old man with severe obstructive sleep apnea (OSA) associated with edema in laryngo-hypopharynx after CCRT for advanced laryngeal and hypopharyngeal cancer. Read More

Sleep Breath 2021 Jun 9. Epub 2021 Jun 9.

China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Objective: The NoSAS score is a new tool widely used in recent years to screen for obstructive sleep apnea. A number of studies have shown that the NoSAS score is more accurate than previous tools, such as the Berlin, STOP-Bang, and STOP questionnaires. Therefore, this meta-analysis assessed the diagnostic value of the NoSAS score for sleep apnea syndrome in comparison to polysomnography. Read More

Sleep Breath 2021 Jun 9. Epub 2021 Jun 9.

School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: Insomnia is frequently co-morbid with obstructive sleep apnea (OSA); the effect of insomnia or co-morbid insomnia and OSA (OSA + I) on associated metabolic outcomes in adults with type 2 diabetes (T2D) remains unclear. This study in adults with T2D compared metabolic outcomes among persons with OSA, insomnia, or OSA + I.

Methods: This study analyzed baseline data from the Diabetes Sleep Treatment Trial of persons recruited for symptoms of OSA or poor sleep quality. Read More

Glob Pediatr Health 2021 28;8:2333794X211019884. Epub 2021 May 28.

Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Obstructive sleep apnea (OSA) in children is leading to several consequences as reported in adults. A continuous positive airway pressure (CPAP) machine is one of the effective treatments in pediatric OSA. However, the CPAP adherence rate is approximately 50%. Read More

Cureus 2021 May 4;13(5):e14833. Epub 2021 May 4.

Diagnostic Radiology, St. Joseph Mercy Oakland Hospital, Pontiac, USA.

Coronavirus disease 2019 (COVID-19) is known to cause a severe acute respiratory syndrome with increased morbidity and mortality due to multiorgan involvement. COVID-19 is associated with an increased risk of venous thromboembolism (VTE), ranging from asymptomatic to potentially fatal presentations. Predictors of VTE in COVID-19 are not fully defined, and the role of anticoagulation in these patients is debatable. Read More

J Surg Case Rep 2021 Jun 7;2021(6):rjab234. Epub 2021 Jun 7.

Department of Otolaryngology, King Hamad University Hospital, Busaiteen, Bahrain.

Antrochoanal polyps (ACP; also known as Killian's polyp) are considered to be the most common type of choanal polyps, making up ~4-6% of all nasal polyps in the general population and ~33% of nasal polyps in the paediatric age group. Patient's suffering from ACP range between the ages of 5 and 80 years. Only 4% of the patients are children aged < than 10 years old. Read More

Sleep Sci 2021 Jan-Mar;14(1):77-81

Hospital Alemán de Buenos Aires, Sleep - Buenos Aires - Capital Federal - Argentina.

Objective: To compare pulse oximetry with manual analysis against all signals of respiratory polygraphy.

Material And Methods: This retrospective study estimated sensitivity (S), specificity (Sp) and positive/negative likelihood ratio (LR+/-) of the oxygen desaturation index (ODI-test) and apnea-hypopnea index (AHI-reference).

Results: 3854 patients (61. Read More

Sleep Sci 2021 Jan-Mar;14(1):19-26

Hospital de Santa Maria, Psychiatry Department - Lisbon - Portugal.

Objective: Obstructive sleep apnoea (OSA) is the most common sleep disorder and its prevalence has increased with the obesity pandemic. We aimed to explore the presence of OSA in severe obesity and to evaluate the association of body mass index (BMI) with sleep architecture, cognition, emotional distress and comorbidities in OSA versus non-OSA patients.

Methods: A sample of 61 patients performed a neuropsychological battery that included tasks of attention, memory, perceptual/visuospatial ability, vocabulary, inhibition, cognitive flexibility and distress symptomatology, before overnight polysomnography. Read More

Methodist Debakey Cardiovasc J 2021 Apr 25;17(1):49-52. Epub 2021 Mar 25.

Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas.

Sleep apnea is highly associated with atrial fibrillation (AF), and both diseases are highly prevalent in the United States. The mechanistic underpinnings that contribute to their association remain uncertain, but numerous possible mechanisms have been proposed, including dysfunction of the cardiac autonomic nervous system (ANS). Studies have reported that apnea induces hyperactivity of the ANS, leading to increases in AF susceptibility. Read More

Zhonghua Jie He He Hu Xi Za Zhi 2021 Jun;44(6):578-582

Zhonghua Jie He He Hu Xi Za Zhi 2021 Jun;44(6):543-549

Department of Respiratory and Critical Care Medicine, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China.

To analyze the diversity, abundance and structural composition of intestinal microflora in patients with different severity of OSAHS, and to explore their potential role in the occurrence and development of OSAHS. A total of 27 healthy volunteers(N) [male 19, female 8, age 22-78(44.4±2. Read More

Epilepsy Behav 2021 Jun 5;121(Pt A):108099. Epub 2021 Jun 5.

Sleep Disorders Center, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Background: The Epworth Sleepiness Scale (ESS) is the most common instrument for measuring subjective sleep propensity in people with epilepsy but has not yet been validated in this population.

Study Objectives: We aimed to systematically assess the validity, performance, and internal consistency of the ESS, as well as correlations between the ESS and disease-specific variables and patient-reported outcome measures in a cohort of adults with epilepsy (AWE).

Methods: Ninety-five AWE completed sleep and seizure diaries, in-laboratory polysomnography (PSG) and patient-reported outcome measures, including the ESS, Insomnia Severity Index (ISI), and the Beck Depression Inventory (BDI). Read More