Search Our Scientific Publications & Authors

Int J Pediatr Otorhinolaryngol 2022 Jun 13;159:111206. Epub 2022 Jun 13.

Department of Otolaryngology, Penn State Milton S Hershey Medical Center, 500 University Drive, Hershey, PA, United States.

Objectives: Transoral robotic surgery in adults confers excellent results and decreased morbidity. Application of these techniques has not yet been rigorously investigated in children. The goal of this study is to evaluate the feasibility of a flexible robotic surgical system in a pediatric population. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):52-57

Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.

Objective: To evaluate a relative telomere length in patients with obstructive sleep apnea (OSA) before and after a 6-month course of continuous positive airway pressure (CPAP) therapy.

Material And Methods: Seventy-five men participated in the study, including 50 men with OSA (the main group 1) and 25 men without OSA (the control group). The average age in the total group was 53. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):6-10

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

At present, the problem of the impact of dietary characteristics on the quality of human sleep is most acute, since it is necessary to have a sufficient level of wakefulness, which is provided by a full-length sleep, for harmonious interaction with the outside world in an urbanized society. Also, the quality of sleep is important factor too, because if the sleep is fragmented, then no matter how long it is - it will not give enough energy. For the quality of sleep, an important role is played not only by the sleep hygiene that a person adheres to, but also by the characteristics of the diet, which can affect the representation of certain phases and stages of sleep. Read More

Sleep Breath 2022 Jun 27. Epub 2022 Jun 27.

Stomatology Center of China Japan Friendship Hospital, Beijing, China.

Purpose: The present meta-analysis aimed to evaluate quantitively the recent scientific evidence regarding the association between obstructive sleep apnea (OSA) and periodontitis.

Methods: Databases searched were PubMed, EMBASE, Scopus, and Web of Science. Publications were included according to the inclusion criteria. Read More

Chronobiol Int 2022 Jun 27:1-30. Epub 2022 Jun 27.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Keck Medical School, University of Southern California, Los Angeles, California, USA.

Atherosclerosis, a chronic inflammatory disease of the arteries that appears to have been as prevalent in ancient as in modern civilizations, is predisposing to life-threatening and life-ending cardiac and vascular complications, such as myocardial and cerebral infarctions. The pathogenesis of atherosclerosis involves intima plaque buildup caused by vascular endothelial dysfunction, cholesterol deposition, smooth muscle proliferation, inflammatory cell infiltration and connective tissue accumulation. Hypertension is an independent and controllable risk factor for atherosclerotic cardiovascular disease (CVD). Read More

Emerg Med Int 2022 16;2022:9536617. Epub 2022 Jun 16.

Department of Nephrology, The First People's Hospital of Fuyang Hangzhou, Hangzhou 311400, Zhejiang, China.

Purpose: To study the changes of liver and kidney function-related indexes in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and analyze their clinical significance.

Method: Ninety OSAHS patients treated in our hospital from April 2019 to April 2021 were selected. According to the apnea-hypopnea Index (AHI), they were divided into mild OSAHS group (5 ≤ AHI < 15 times/h, 35 people), moderate OSAHS group (15 ≤ AHI < 30 times/h, 35 people), and severe OSAHS group (AHI ≥ 30 times/h, 20 people). Read More

Anaesth Rep 2022 Jan-Jun;10(1):e12172. Epub 2022 Jun 17.

Department of Paediatric Surgery Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India.

A nine-year-old girl diagnosed with ROHHAD-NET (rapid-onset obesity, hypothalamic dysfunction, hypoventilation, autonomic dysfunction and neuroendocrine tumour) syndrome was scheduled for excision of a large paravertebral ganglioneuroma under general anaesthesia. Her comorbidities included hypothyroidism, diabetes insipidus and autonomic dysfunction. Intra- and postoperative complications included intra-operative hypotension, long surgical time and prolonged postoperative ventilation. Read More

Nat Sci Sleep 2022 20;14:1165-1174. Epub 2022 Jun 20.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, People's Republic of China.

Purpose: To investigate the relationship between sleep disturbances before pregnancy and the subsequent risk for gestational diabetes mellitus (GDM).

Patients And Methods: Pregnant women who attended antenatal clinic before the 12th gestational week between September 2019 and June 2020 were enrolled. The sleep status at the month before the last menstrual period was collected by filling the Pittsburgh Sleep Quality Index (PSQI) and Berlin Questionnaire (BQ) to evaluate the sleep duration, quality and the risk of obstructive sleep apnea (OSA). Read More

Sleep Sci 2022 Apr-Jun;15(2):259-264

Amir Alam Hospital, Tehran University of Medical Sciences, Otorhinolaryngology Research Center - Tehran - Iran.

Introduction: Patients with migraine, who suffer from sleep apnea, whether obstructive or central, might lead to treatment-resistant headaches. In this study, we have reported a 42-year-old man with a confirmed treatment-resistant migraine headaches and hemiplegic attacks, who was referred to our sleep clinic for evaluation of sleep breathing problems.

Case Report: The patient had recurrent attacks of migraine headaches with hemiplegic attacks. Read More

Sleep Sci 2022 Apr-Jun;15(2):224-244

University of Porto, UMIB - Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto - Porto - Portugal.

Objectives: Physiological and restorative sleep is fundamental for physical and mental well-being. Polysomnography parameters are objective methods to access sleep structure. Antiepileptic drugs (AEDs) are a group of drugs whose interference in the sleep structure is still not well known, especially in what concern the new ones. Read More

Sleep Sci 2022 Apr-Jun;15(2):196-200

Tehran University of Medical Sciences, Occupational Sleep Research Center, Baharloo Hospital - Tehran - Iran.

Objective: Several studies confirmed a positive association between obstructive sleep apnea (OSA) and metabolic syndrome. Continuous positive airway pressure (CPAP) is the main treatment for patients with moderate and severe OSA. CPAP therapy in adults with OSA results in reduction in sleepiness, blood pressure and improvement of metabolic profile. Read More

Sleep Sci 2022 Apr-Jun;15(2):250-258

University of British Columbia, Anesthesiology, Pharmacology and Therapeutics - Vancouver - BC - Canada.

Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide, accounting for nearly 18 million deaths per year. Among other considerations, treating CVDs requires better understanding their risk factors. Sleep-disordered breathing, especially obstructive sleep apnea (OSA), is a likely contributor to several CVDs. Read More

Sleep Sci 2022 Apr-Jun;15(2):136-142

Federal University of the State of Rio de Janeiro, Department of Quantitative Methods of the Federal University of the State of Rio de Janeiro - Rio de Janeiro - Brazil.

Objectives: Obstructive sleep apnea (OSA) affects approximately one third of the population and can reach 90% prevalence in the elderly. There are screening tools to track the disease, however, their performance may differ according to population characteristics. This study aims to determine sensitivity, specificity, predictive value, likelihood ratio, and accuracy of the Berlin (BQ) and STOP-Bang (S-Bang) questionnaires and the Epworth sleepiness scale (ESS), comparing their performances, using polysomnography (PSG) as a gold standard, in a sample of elderly. Read More

Compr Psychoneuroendocrinol 2022 May 4;10:100128. Epub 2022 Mar 4.

Sleep Education and Research Laboratory, UCL Institute of Education, London, UK.

Background: Neurocognitive impairment is common in people with Sickle Cell Disease (SCD) and evidence is accumulating that sleep disturbances play a role. The interaction between cortisol and sleep in the general population is associated with cognition as well as general wellbeing but there are few data in SCD. We aimed to understand the relationship between cortisol and sleep in individuals with SCD and explored associations with cognition. Read More

BMC Med Inform Decis Mak 2022 Jun 26;22(1):168. Epub 2022 Jun 26.

Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Continues positive airway pressure (CPAP) therapy is a gold standard treatment for moderate to severe cases of OSA (obstructive sleep apnea). The present research aimed to describe the analysis, design, and evaluation of a telemonitoring system to improve CPAP adherence in patients afflicted with OSA.

Methods: The telemonitoring system was developed in five phases. Read More

Sleep Health 2022 Jun 23:713. Epub 2022 Jun 23.

Program in Public Health, Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, New York, NY, USA.

Objectives: Following an earlier National Health and Nutrition Examination Survey (NHANES) 2005-2008 analysis, we investigated the association between urine antimony and sleep health using more recent data, new measures of sleep health, and multiple measures of urine density adjustment in NHANES 2009-2016.

Design: A cross-sectional study.

Setting: United States, national population-based survey. Read More

J Clin Neurosci 2022 Jun 23;102:87-94. Epub 2022 Jun 23.

Department of Respiratory, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

Introduction: Recent studies indicate that Alzheimer's disease- (AD) related biomarkers, including amyloid β (Aβ40 and Aβ42) and tau proteins (P-tau and T-tau), in blood and cerebrospinal fluid (CSF) are associated with obstructive sleep apnea (OSA). However, the results have been inconsistent. Therefore, the primary purpose of this meta-analysis was to determine the relationship between blood and CSF AD-related biomarkers and OSA. Read More

Sleep Med Rev 2022 Jun 7;64:101659. Epub 2022 Jun 7.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB-Center for Innovation in Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; IIIUC-Institute of Interdisciplinary Research, University of Coimbra, Coimbra, Portugal. Electronic address:

Background: Obstructive Sleep Apnea (OSA) has been recognized as a major health concern worldwide, given its increasing prevalence, difficulties in diagnosis and treatment, and impact on health, economy, and society. Clinical guidelines highlight the need of biomarkers to guide OSA clinical decision-making, but so far, without success. In this systematic review and meta-analysis, registered on the International Prospective Register of Systematic Reviews database (ID CRD42020132556), we proposed to gather and further explore candidates identified in the literature as potential OSA biomarkers. Read More

BMC Pulm Med 2022 Jun 25;22(1):248. Epub 2022 Jun 25.

HUH Heart and Lung Center, University of Helsinki and Helsinki University Hospital, (Haartmaninkatu 4), P.O. Box 372, 00029, Helsinki, Finland.

Background: Chronic respiratory failure (CRF) can be treated at home with non-invasive ventilation (NIV) and/or long-term oxygen (LTOT). The prevalence of these treatments is largely unknown. We aimed to clarify the prevalence and indications of the treatments, and the three-year mortality of the treated patients in the Helsinki University Hospital (HUH) area in Finland. Read More

Sleep Breath 2022 Jun 25. Epub 2022 Jun 25.

School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Purpose: Body composition is considered to be associated with obstructive sleep apnea (OSA) severity. This cross-sectional study aimed to examine associations of overnight body composition changes with positional OSA.

Methods: The body composition of patients diagnosed with non-positional and positional OSA was measured before and after overnight polysomnography. Read More

Sleep Breath 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, Wisconsin Sleep, Wisconsin Institute for Sleep and Consciousness, School of Medicine and Public Health, University of Wisconsin-Madison, 1685 Highland Ave, Madison, WI, 53705, USA.

Purpose: To evaluate whether or not continuous positive airway pressure (CPAP) treatment in pregnancies complicated by obstructive sleep apnea (OSA) is associated with a decrease in hypertensive disorders of pregnancy.

Methods: This was a retrospective cohort study of perinatal outcomes in women who underwent objective OSA testing and treatment as part of routine clinical care during pregnancy. Where diagnostic criteria for OSA were reached (respiratory event index (REI) ≥ 5 events per hour), patients were offered CPAP therapy. Read More

J Vasc Nurs 2022 Jun 15;40(2):74-85. Epub 2022 Feb 15.

University of South Carolina School of Medicine-Greenville, Greenville, SC, USA. Electronic address:

Background: The eligibility criteria for thrombolytic therapy may differ between acute ischemic stroke patients (AIS) patients with and without incidence of obstructive sleep apnea (OSA). In this study, we determine the effect of specific comorbidities in the exclusion and inclusion for recombinant tissue plasminogen activator (rtPA) administration in the AIS population with OSA.

Methods: Retrospective data from a stroke registry were analyzed for baseline clinical and demographic factors in AIS patients with OSA for rtPA therapy from January 2010 to June 2016. Read More

Physiol Rep 2022 Jun;10(12):e15360

University of California, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, La Jolla, California, USA.

There is a need for alternatives to positive airway pressure for the treatment of obstructive sleep apnea and snoring. Improving upper airway dilator function might alleviate upper airway obstruction. We hypothesized that transoral neuromuscular stimulation would reduce upper airway collapse in concert with improvement in genioglossal muscle function. Read More

Br J Cardiol 2022 8;29(1):10. Epub 2022 Mar 8.

Respiratory Consultant and Sleep Physician, and Sleep and Ventilation Lead Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield Teaching Hospital, Herries Road, Sheffield, S5 7AU.

ERJ Open Res 2022 Apr 20;8(2). Epub 2022 Jun 20.

Dept of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Background: Obstructive sleep apnoea (OSA) is a common chronic condition that is associated with significant morbidity and economic cost. Prolonged wait times are increasingly being recognised as a barrier to diagnosis and treatment of many chronic diseases; however, no study to date has prospectively evaluated the impact of wait times on health outcomes in OSA.

Objective: The purpose of this study is to determine whether treatment outcomes for individuals with OSA differ between patients managed using an expedited standard pathway. Read More

Cureus 2022 May 23;14(5):e25230. Epub 2022 May 23.

Department of Pulmonary Medicine, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, IND.

Sleep-disordered breathing (SDB) is highly prevalent in patients with cancer and affects their prognosis. However, data on SDB in lung cancer patients are lacking, and few studies have conducted level I polysomnography (PSG) in this patient population. This study aimed to measure SDB in newly diagnosed lung cancer patients at the sleep clinic of a tertiary respiratory institute in New Delhi, India, for eight months. Read More

Medicina (Kaunas) 2022 Jun 2;58(6). Epub 2022 Jun 2.

Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave JJN3-01, Cleveland, OH 44195, USA.

: Patients with pre-existing cardiac disease have a higher prevalence of Obstructive Sleep Apnea (OSA). OSA has been associated with an increased risk of supraventricular and ventricular arrhythmia. We screened subjects with implanted pacemakers and automated implantable cardioverter defibrillators (AICD) for OSA with the Berlin Questionnaire and compared the incidence of ventricular arrhythmias and automated implantable cardioverter defibrillator (AICD) firing between high and low OSA risk groups. Read More

Life (Basel) 2022 Jun 2;12(6). Epub 2022 Jun 2.

Faculty of Medicine, Institute of Orthodontics, University of Coimbra, 3000-075 Coimbra, Portugal.

Background: Mandibular Advancement Devices (MADs), inserted in non-surgical treatments for obstructive sleep apnea and hypopnea syndrome (OSAHS), are used intra-orally during the sleep period, with the aim of promoting mandibular protrusion. The aim of the study is to analyze the changes in the upper airway after the use of an MAD in the treatment of OSAHS.

Methods: 60 patients diagnosed with OSAHS, as established by the Sleep Medicine Service, underwent treatment with the Silensor SL device at the Stomatology Service of the University Hospital Center of Coimbra, from January 2018 to January 2019. Read More

J Pers Med 2022 Jun 16;12(6). Epub 2022 Jun 16.

First Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, Greece.

Obstructive sleep apnea (OSA) is a rising problem, with important implications for public health. Recent evidence has revealed a link between OSA and reduced male fertility. We investigated the association between OSA and sexual and erectile function, as well as semen quality, and the effect of treatment by continuous positive airway pressure (CPAP). Read More

J Pers Med 2022 Jun 5;12(6). Epub 2022 Jun 5.

Institute of Medicine, Chung Shan Medical University, Taichung 406, Taiwan.

Obstructive sleep apnea (OSA) yields intermittent hypoxia, hypercapnia, and sleep fragmentation. OSA is associated with chronic medical conditions such as cardiovascular diseases, metabolic syndrome, and neurocognitive dysfunction. However, the risk of infertility in OSA remains unclear due to limited data and lack of long-term population-based studies. Read More