12,467 results match your criteria Obstructed Megaureter


Case report of the successful use of Mirena levonorgestrel intrauterine system in a patient with didelphys uterus and obstructed hemivagina.

Authors:
King Cp Kives S

J Pediatr Adolesc Gynecol 2018 Dec 8. Epub 2018 Dec 8.

Section of Paediatric Gynaecology, Division of Endocrinology, Hospital for Sick Children, and the Department of Obstetrics and Gynecology, University of Toronto, 7435A-555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.

Background: The Mirena levonorgestrel intrauterine system (IUS) is frequently used for menstrual suppression in adolescents with special needs. However, the presence of a uterine anomaly is generally considered a contraindication to IUS insertion, thereby excluding a potentially highly effective option for this patient population.

Case: A Mirena IUS was utilized in a medically and surgically complex special needs 14-year-old adolescent with a didelphys uterus and obstructed hemivagina. Read More

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December 2018

[Gastric intramural pseudocyst in a heterotopic pancreas causing gastric outlet obstruction. Report of one case].

Rev Med Chil 2018 Aug;146(8):933-937

Servicio de Cirugía, Clínica Alemana, Santiago, Chile.

Heterotopic pancreas is a silent gastrointestinal malformation that may become clinically evident when complicated by inflammation and pseudocyst formation. We report a 26 year-old male presenting with vomiting, pain and abdominal distention. An abdominal CT scan showed an important gastric distention secondary to a 4-cm cystic lesion located in the antrum wall. Read More

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Ubiquitin-dependent switch during assembly of the proteasomal ATPases mediated by Not4 ubiquitin ligase.

Proc Natl Acad Sci U S A 2018 Dec 10. Epub 2018 Dec 10.

Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309

In the proteasome holoenzyme, the hexameric ATPases (Rpt1-Rpt6) enable degradation of ubiquitinated proteins by unfolding and translocating them into the proteolytic core particle. During early-stage proteasome assembly, individual Rpt proteins assemble into the hexameric "Rpt ring" through binding to their cognate chaperones: Nas2, Hsm3, Nas6, and Rpn14. Here, we show that Rpt ring assembly employs a specific ubiquitination-mediated control. Read More

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December 2018

Challenges and Opportunities in Adolescent Gynecology Patients with Surgically-Treated Congenital and Acquired Anomalies: Transition of Care from Pediatric to Adult Surgery.

J Pediatr Adolesc Gynecol 2018 Dec 5. Epub 2018 Dec 5.

Department of obstetrics and gynecology, university of Louisville, USA.

The transition from adolescence to young adulthood in patients with reproductive health care needs such as disorders of sexual development (DSDs) and congenital anomalies is a complex process occurring over several years. The transition process for these patients has is still poorly understood. The patients with DSDs and reproductive issues have specific and unique issues regarding timing of disclosure of diagnosis, genital examinations, gonadectomy, vaginal treatments, surgical procedures hormone replacement therapy, use of long term medication and potential cancer screening. Read More

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December 2018

Peroxiredoxin 3 deficiency accelerates chronic kidney injury in mice through interactions between macrophages and tubular epithelial cells.

Free Radic Biol Med 2018 Dec 4. Epub 2018 Dec 4.

Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea. Electronic address:

Chronic kidney disease (CKD) has become epidemic worldwide. Mitochondrial reactive oxygen species (ROS)-induced oxidative stress is an important mediator of CKD, and Prx3 plays a critical role in maintenance of mitochondrial ROS. The present study examined the role of Prx3 in the context of fibrosis, a common feature of CKD, using Prx3 KO mice under obstructive and diabetic stress. Read More

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December 2018

Takotsubo syndrome with pulmonary embolism: a case report and literature review.

BMC Cardiovasc Disord 2018 Dec 10;18(1):229. Epub 2018 Dec 10.

Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, 100037, China.

Background: Takotsubo syndrome (TTS) is an acute cardiac condition with reversible heart failure which is often triggered by psychological and physical stressful events. Although pulmonary embolism (PE) was reported as a trigger for TTS, the concurrence of TTS and PE has been rarely reported, let alone that triggered by PE. Here we describe a case of a postmenopausal female presenting with symptoms similar to myocardial ischemia, which may be caused by PE, and review the available literature that may help clinicians with their practice to similar situations since no published guidelines are available. Read More

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December 2018

Time-Dependent Alterations of Gut Wall Integrity in Small Bowel Obstruction in Mice.

J Surg Res 2019 Jan 3;233:249-255. Epub 2018 Sep 3.

Department of Surgery, Vivantes Hospital Neukölln, Berlin, Germany.

Background: Small bowel obstruction (SBO) is one of the most common disorders in surgical emergency departments. Without resolution of the obstructed bowel segments, patients may develop multiorgan failure. The aim of this study was to investigate whether morphological damage of the intestinal wall during SBO may lead to molecular translocation and how this may impair intestinal motility. Read More

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January 2019

HELLS regulates chromatin remodeling and epigenetic silencing of multiple tumor suppressor genes in human hepatocellular carcinoma.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.

Hepatocellular carcinoma (HCC) is the third lethal cancer worldwide. Increasing evidence showed that epigenetic alterations play an important role in human carcinogenesis. Deregulation of DNA methylation and histone modifications have recently been characterized in HCC, but the significance of chromatin remodeling in liver carcinogenesis remains to be explored. Read More

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December 2018
3 Reads

Uterine rupture among mothers admitted for obstetrics care and associated factors in referral hospitals of Amhara regional state, institution-based cross-sectional study, Northern Ethiopia, 2013-2017.

PLoS One 2018 4;13(12):e0208470. Epub 2018 Dec 4.

Departments of Human Nutrition, Debremarkos University, Debremarkos, Ethiopia.

Background: Maternal morbidity and mortality have been one of the most challenging health problems that concern the globe over the years. Uterine rupture is one of the peripartum complications, which cause nearly about one out of thirteen maternal deaths. This study aimed to assess the prevalence and associated factors of uterine rupture among obstetric case in referral hospitals of Amhara Regional State, Northern Ethiopia. Read More

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December 2018
3 Reads

Enterocele Reduction in the Prone Position: New Horizons for Safer Stapled Transanal Rectal Resections.

Surg Technol Int 2018 Nov 30;34. Epub 2018 Nov 30.

Rectal Surgery Residency Program, Department of Colon and Rectal Surgery, St. Mark's Hospital, Salt Lake City, UT.

Aim: The presence of enterocele may interfere with the surgical approach for obstructed defecation syndrome (ODS) as it may represent a contraindication to stapled transanal rectal resection (STARR), and tactics to overcome this problem have been debated. A change in the patient's position during surgery may be a means to overcome an enterocele. We sought to determine whether an enterocele could be completely reduced when the patient is placed in the prone position during fluoroscopic defecography (FD). Read More

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November 2018
1 Read

Use of a criteria-based audit to optimize uptake of cesarean delivery in a low-resource setting.

Int J Gynaecol Obstet 2018 Nov 30. Epub 2018 Nov 30.

Department of Women's and Children's Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden.

Objective: To evaluate the impact of criteria-based audit (CBA) of obstructed labor and fetal distress on cesarean delivery and perinatal outcomes.

Methods: A cross-sectional study was performed at a tertiary referral hospital in Tanzania. Data were collected before and after CBA (January 2013-November 2013 and July 2015-June 2016). Read More

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November 2018

Spectrum of urologic complications in obstetrics and gynecology: 13 years' experience from a tertiary referral center.

Turk J Urol 2018 Nov 26:1-6. Epub 2018 Nov 26.

Department of Urology, King George's Medical University, Lucknow, India.

Objective: To analyze the patterns of presentation and management for urologic complications of obstetrics and gynecology in the form of genitourinary fistulas at a tertiary referral center and highlight the social issues associated with them.

Material And Methods: We conducted this retrospective study analyzing 311 patients with genitourinary fistulas after obstetric and gynecologic surgeries between January 2005 and January 2018. We recorded the patients' characteristics and area of residence and then analyzed the etiology, surgical management and success rates by grouping the patients into four types of genitourinary fistulas. Read More

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November 2018

Differential expression profiles of long non‑coding RNAs during the mouse pronuclear stage under normal gravity and simulated microgravity.

Mol Med Rep 2018 Nov 20. Epub 2018 Nov 20.

College of Animal Science, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro‑Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, P.R. China.

Pronuclear migration, which is the initial stage of embryonic development and the marker of zygote formation, is a crucial process during mammalian preimplantation embryonic development. Recent studies have revealed that long non‑coding RNAs (lncRNAs) serve an important role in early embryonic development. However, the functional regulation of lncRNAs in this process has yet to be elucidated, largely due to the difficulty of assessing gene expression alterations during the very short time in which pronuclear migration occurs. Read More

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November 2018
1.484 Impact Factor

Slow and fast grouping of cargo velocities in axonal transport due to single versus multi-motor transport.

J Theor Biol 2018 Nov 23. Epub 2018 Nov 23.

Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America; Department of Biomedical Engineering, Emory University, Atlanta, Georgia, United States of America. Electronic address:

We have recently been exploring the idea that axonal transport velocity is "track and motor limited." That is, microtubule length as well as microtubule-associated obstructions interact with the number of motors attached to a specific cargo to determine average cargo velocities. We assert that "slow" and "fast" transport as they are commonly referred to in the literature are really single- versus multi-motor transport along interrupted and obstructed track. Read More

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November 2018

The protective role of intermedin in promoting angiogenesis during renal fibrosis.

Gene 2018 Nov 22;688:34-43. Epub 2018 Nov 22.

Department of Nephrology, Shanxi Provincial People's Hospital, The Affiliated People's Hospital of Shanxi Medical University, Shanxi Kidney Disease Institute, Taiyuan, Shanxi 030012, China.

Background: Renal fibrosis promotes the progression of chronic renal disease to end-stage renal disease. Microvascular damage and loss play an important role in renal fibrosis. Intermedin (IMD) is expressed mainly in the heart and kidney. Read More

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November 2018
4 Reads

Partially Obstructed Longitudinal Vaginal Septum Presenting in Adulthood With Complaint of Urinary Incontinence.

Urology 2018 Nov 22. Epub 2018 Nov 22.

University of Pennsylvania, Division of Urology, Philadelphia, PA.

A longitudinal vaginal septum can be obstructive or nonobstructive. We report on an adult woman who presented with involuntary fluid loss per vagina and had a partially obstructive longitudinal vaginal septum. A 36-year-old nulliparous female presented with malodorous, clear, leakage per vagina that she described as "urinary incontinence. Read More

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November 2018
4 Reads

Self-healing high-dimensional quantum key distribution using hybrid spin-orbit Bessel states.

Opt Express 2018 Oct;26(21):26946-26960

Using spatial modes for quantum key distribution (QKD) has become highly topical due to their infinite dimensionality, promising high information capacity per photon. However, spatial distortions reduce the feasible secret key rates and compromise the security of a quantum channel. In an extreme form such a distortion might be a physical obstacle, impeding line-of-sight for free-space channels. Read More

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October 2018

A 40-MHz Ultrasound Transducer with an Angled Aperture for Guiding Percutaneous Revascularization of Chronic Total Occlusion: A Feasibility Study.

Sensors (Basel) 2018 Nov 21;18(11). Epub 2018 Nov 21.

Department of Electronic Engineering, Sogang University, Seoul 04107, Korea.

Complete blockage of a coronary artery, called chronic total occlusion (CTO), frequently occurs due to atherosclerosis. To reopen the obstructed blood vessels with a stent, guidewire crossing is performed with the help of angiography that can provide the location of CTO lesions and the image of guidewire tip. Since angiography is incapable of imaging inside a CTO lesion, the surgeons are blind during guidewire crossing. Read More

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November 2018
1 Read

Overcoming the Challenging Cervix: Identification and Techniques to Access the Uterine Cavity.

Obstet Gynecol Surv 2018 Nov;73(11):641-649

Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Wright State University, Boonshoft School of Medicine, Dayton, OH.

Importance: Cervical stenosis is a challenging clinical entity that requires prompt identification and management in order to avoid iatrogenic injury at the time of endocervical canal cannulation.

Objective: The aim of this study was to identify cervical stenosis and discuss associated etiologies, risk factors, and review medical and surgical approaches for overcoming cervical stenosis.

Evidence Acquisition: Computerized searches of MEDLINE and PubMed were conducted using the key words "cervix", "cervical stenosis," "embryo transfer," "hysteroscopy complications," "misoprostol," and "ultrasound. Read More

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November 2018
3 Reads

Drug-free albumin-triggered sensitization of cancer cells to anticancer drugs.

J Control Release 2018 Nov 19;293:84-93. Epub 2018 Nov 19.

Department of Pharmaceutics and Pharmaceutical Chemistry/Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA; Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA. Electronic address:

Chemosensitization strategies have been used to sensitize cancer cells to conventional drugs, but their utility is often obstructed by additional off-target toxicity, limited access to intracellular targets and heterogeneous tumor pathogenesis. To address these challenges, we rationally developed a drug-free human serum albumin (HSA)-based therapeutic (KH-1) that functions extracellularly and exhibits pleiotropic effect on multiple intracellular signaling pathways. It is a two-step touch-trigger system that consists of a pretargeting anchor on surface receptor CD20 (anti-CD20 Fab' conjugated with a morpholino oligonucleotide 1) and a CD20 clustering actuator (HSA grafted with multiple copies of complementary morpholino oligonucleotide 2). Read More

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November 2018
1 Read

A road to obstetric fistula in Malawi: capturing women's perspectives through a framework of three delays.

Int J Womens Health 2018 5;10:699-713. Epub 2018 Nov 5.

Kamuzu College of Nursing, University of Malawi, Blantyre, Malawi.

Introduction: Obstetric fistula (OF) is a devastating birth injury, which leaves a woman with leaking urine and/or feces accompanied by bad smell, a situation that has been likened to death itself. The condition is caused by neglected obstructed labor. Many factors underlie fistula formation, most of which are preventable. Read More

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November 2018
1 Read

Outcomes for symptomatic non-obstructed individuals and individuals with mild (GOLD stage 1) COPD in a population based cohort.

Int J Chron Obstruct Pulmon Dis 2018 26;13:3549-3561. Epub 2018 Oct 26.

Federal University of Pelotas, Pelotas, Brazil.

Background: We aimed to study the adverse outcomes of symptomatic and asymptomatic non-obstructed individuals and those with mild COPD longitudinally in participants from three Latin-American cities.

Methods: Two population-based surveys of adults with spirometry were conducted for these same individuals with a 5- to 9-year interval. We evaluated the impact of respiratory symptoms (cough, phlegm, wheezing or dyspnea) in non-obstructed individuals, and among those classified as Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 1, COPD on exacerbation frequency, mortality and FEV decline, compared with asymptomatic individuals without airflow obstruction or restriction. Read More

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October 2018
2 Reads

Wilkie's syndrome admitted for acute abdomen: A case presentation.

Turk Pediatri Ars 2018 Sep 1;53(3):193-196. Epub 2018 Sep 1.

Department of Pediatrics, Division of Pediatric Gastroneterology, Hepatology and Nutrition, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey.

Superior mesenteric artery syndrome, also known as Wilkie's Syndrome, is a life threatening clinical entity which developes as a result of obstructed second or third part of duodenum compressed between aorta and superior mesenteric artery. In this rare syndrome, a rapid weight loss is accompanied by stomach ache, abdominal distension, lack of appetite, nausea and vomiting after meals. In patients admitted for acute abdomen, superior mesenteric artery syndrome should be included in the differential diagnosis in case of a preceeding rapid weight loss. Read More

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September 2018

Modified ex utero intrapartum treatment procedure in a bicornuate uterus breech presentation Pierre Robin fetus with severe micrognathia and cleft palate.

Clin Case Rep 2018 Nov 12;6(11):2040-2044. Epub 2018 Sep 12.

Department of Gynecology and Obstetrics Rambam Health Care Campus Haifa Israel.

Thorough prenatal evaluation allows for identification of fetuses with compromised airway. The ex utero intrapartum treatment procedure enables maintaining uteroplacental circulation during cesarean section while securing a potentially obstructed fetal airway, converting a potentially catastrophic situation into a controlled one. An expert multidisciplinary team is the key to success. Read More

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November 2018
2 Reads

Can the Penile Cuff Test Predict the Outcome of Holmium Laser Enucleation of the Prostate for Benign Prostatic Obstruction?

Urology 2018 Nov 16. Epub 2018 Nov 16.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Electronic address:

Objective: To determine whether the penile cuff test can predict surgical outcomes prior to Holmium laser enucleation of the prostate for benign prostatic obstruction.

Methods: Men scheduled to undergo Holmium laser enucleation of the prostate were enrolled in this study, and all patients underwent the penile cuff test prior to and 3 months after surgery. Patients were categorized as obstructed, nonobstructed, or uncertain by nomogram. Read More

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November 2018
1 Read

Laparoscopic Ventral Rectopexy Versus Stapled Trans-Anal Rectal Resection for Treatment of Obstructed Defecation in the Elderly: Long-Term Results of a Prospective Randomized Study.

Dis Colon Rectum 2018 Nov 15. Epub 2018 Nov 15.

Department of Surgery, Section of Colon and Rectal Surgery, University of Alexandria, Alexandria, Egypt.

Background: Obstructed defecation is a common complaint in coloproctology. Many anal, abdominal, and laparoscopic procedures are adopted to correct the underlying condition.

Objective: The purpose of this study was to compare long-term functional outcome, recurrence rate, and quality of life between laparoscopic ventral rectopexy and stapled transanal rectal resection in the treatment of obstructed defecation. Read More

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November 2018
4 Reads

The Contributions of Internal Intussusception, Irritable Bowel Syndrome, and Pelvic Floor Dyssynergia to Obstructed Defecation Syndrome.

Dis Colon Rectum 2018 Nov 15. Epub 2018 Nov 15.

Background: Recently, there has been a trend toward surgical management of internal intussusception despite an unclear correlation with constipation symptoms.

Objective: This study characterizes constipation in patients with obstructed defecation syndrome and identifies whether internal intussusception or other diagnoses such as irritable bowel syndrome may be contributing to symptoms.

Design: Patients evaluated for obstructed defecation at a pelvic floor disorder center were studied from a prospectively maintained database. Read More

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November 2018
1 Read

Tubulocystic anomalies of the mesonephric duct associated with ipsilateral renal dysgenesis.

J Pediatr Urol 2018 Sep 6. Epub 2018 Sep 6.

Department of Paediatric Surgery and Urology, Birmingham Children's Hospital, Steelhouse Lane, Birmingham, B4 6NH, United Kingdom. Electronic address:

Introduction: Renal agenesis and multicystic dysplastic kidney (MCDK) are usually associated with either an absent or atretic ureter. Occasionally, these renal anomalies may be associated with a dilated tortuous ureter, ureterocele or other cystic malformation of mesonephric duct (MND) remnants.

Objectives: The objective of this study was to identify and classify anatomical variants of tubulocystic remnants of the MND, with a secondary focus on natural history and management outcomes. Read More

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September 2018
7 Reads

Role of Sirolimus in renal tubular apoptosis in response to unilateral ureteral obstruction.

Int J Med Sci 2018 7;15(13):1433-1442. Epub 2018 Sep 7.

Transplantation centre, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.

Renal tubule cell apoptosis plays a pivotal role in the progression of chronic renal diseases. The previous study indicates that Sirolimus is effective on unilateral ureteral obstruction (UUO)-induced renal fibrosis. However, the role of Sirolimus in renal tubular apoptosis induced by UUO has not yet been addressed. Read More

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September 2018
5 Reads

Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats.

Life Sci 2018 Nov 12. Epub 2018 Nov 12.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. Electronic address:

The present study aimed to evaluate the renoprotective effects of chelerythrine (CHE), a protein kinase C inhibitor, on neonatal rats after partial unilateral ureteral obstruction (UUO) surgery. New born Sprague Dawley rats were subjected to partial UUO 48 h after birth and received a daily intraperitoneal injection of 5 mg/kg CHE. At 21-day age, the rats were scarified and the kidneys were collected for analysis. Read More

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November 2018
6 Reads

Prognostic and predictive value of interstitial cells of Cajal populations following stapled transanal rectal resection (STARR) in patients with obstructed defecation syndrome.

Gastroenterol Rep (Oxf) 2018 Nov 1;6(4):270-276. Epub 2018 Oct 1.

Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, Guangdong, China.

Objective: The present study was designed to evaluate the functional outcome of stapled transanal rectal resection (STARR) and to examine the relationship between the population density of the interstitial cells of Cajal (ICC) and the efficacy of the STARR operation in the management of obstructed defecation syndrome (ODS) patients.

Methods: Full-thickness rectal samples were obtained from 50 ODS patients who underwent STARR. Samples were analysed using ICC immunohistochemistry. Read More

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November 2018
3 Reads

Platelet bio-nanobubbles as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics.

Theranostics 2018 9;8(18):4870-4883. Epub 2018 Sep 9.

State key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing, 210096, China.

Since the expected therapeutic results of ischemic stroke are strictly time dependent, early and accurate diagnosis as well as short intervals between diagnosis and treatment are key factors for the survival of stroke patients. In this study, we fabricated platelet (PLT) membrane-derived biomimetic nanobubbles (PNBs) for timely perfusion intervention and ultrasound imaging of acute ischemic stroke. The PNBs are fabricated by sonication-assisted reassembly of repeatedly freeze-thawed live platelet-derived PLT membrane vesicles (PMVs). Read More

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September 2018
6 Reads

A Comparison of GLI12 with NHANES III Spirometry Reference Values: The Implications in Defining Obstruction.

Ann Am Thorac Soc 2018 Nov 14. Epub 2018 Nov 14.

US Army Brooke Army Medical Center, 3998, Pulmonary/Critical Care , Fort Sam Houston, Texas, United States.

Rationale: Obstructive lung disease is diagnosed by a decreased ratio of forced expiratory volume in the first second (FEV1) to forced vital capacity (FVC); however, there is no universally accepted lower limit of normal (LLN) for the FEV1/FVC ratio. Current established reference values use the NHANES III database. In 2012, the Global Lung Initiative (GLI) introduced GLI12: a compilation reference set that uses standard deviation values to define normal spirometry. Read More

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November 2018
3 Reads

[Accessibility to Electroconvulsive Therapy in Hungary].

Psychiatr Hung 2018 ;33(3):266-269

Jahn Ferenc Del-pesti Korhaz, Pszichiatriai es Addiktologai Centrum, Budapest, Hungary, E-mail:

Introduction: In spite of its efficacy, use of electroconvulsive therapy (ECT) has been declined in Hungary over the past decade. This survey explores the circumstances that have obstructed the accessibility to ECT in Hungary.

Methods: This study was part of a comprehensive survey on the use of ECT in which two semi-structured questionnaires with 25 and 6 questions were sent out to all psychiatric departments in Hungary. Read More

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January 2018

Barriers to access and utilization of emergency obstetric care at health facilities in sub-Saharan Africa: a systematic review of literature.

Syst Rev 2018 Nov 13;7(1):183. Epub 2018 Nov 13.

Research Centre for Generational Health and Ageing, School of Medicine and Public Health, Faculty of Health and Medicine, The University of Newcastle, Newcastle, Australia.

Background: Nearly 15% of pregnancies end in fatal perinatal obstetric complications including bleeding, infections, hypertension, obstructed labour and complications of abortion. Globally, an estimated 10.7 million women have died due to obstetric complications in the last two decades, and two thirds of these deaths occurred in sub-Saharan Africa. Read More

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November 2018
6 Reads

Antitumor effects of β-elemene via targeting the phosphorylation of insulin receptor.

Endocr Relat Cancer 2018 Nov 1. Epub 2018 Nov 1.

L Huang, pathophysiology, Dalian Medical University, Dalian, China.

Ewing sarcoma family tumors (ESFTs) are a group of aggressive and highly metastatic tumors lacking efficient therapies. Insulin-like growth factor 1 receptor (IGF1R) blockade is one of the most efficient targeting therapy for ESFTs. However, the appliance is obstructed by drug resistance and disease recurrence due to the activation of insulin receptor (IR) signaling induced by IGF1R blockade. Read More

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November 2018
4 Reads

Elevated urinary lipocalin-2, interleukin-6 and monocyte chemoattractant protein-1 levels in children with congenital ureteropelvic junction obstruction.

J Pediatr Urol 2018 Oct 17. Epub 2018 Oct 17.

Xinjiang Institute of Pediatrics, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China. Electronic address:

Introduction: In children with congenital ureteropelvic junction obstruction (UPJO), urinary biomarkers could assist in the diagnosis of renal damage or kidneys at risk for damage. Urinary levels of interleukin-6 (IL6), neutrophil gelatinase-associated lipocalin (LCN2), monocyte chemoattractant protein-1 (MCP1), and transforming growth factor-β1 (TGFB1) proteins have been correlated with renal damage in several contexts. Whether they might be useful non-invasive biomarkers of obstructive nephropathy due to unilateral and bilateral congenital UPJO was tested. Read More

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October 2018
5 Reads

Granulocyte macrophage-colony stimulating factor: A key modulator of renal mononuclear phagocyte plasticity.

Immunobiology 2018 Nov 2. Epub 2018 Nov 2.

The University of Edinburgh/ Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent Edinburgh EH16 4TJ, Scotland, United Kingdom.

Macrophage-colony stimulating factor (M-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF) play key roles in the differentiation of macrophages and dendritic cells (DCs). We examined the effect of treatment with M-CSF-containing macrophage medium or GM-CSF-containing DC medium upon the phenotype of murine bone marrow-derived macrophages and DCs. Culture of macrophages for 5 days in DC medium reduced F4/80 expression and increased CD11c expression with cells effectively stimulating T cell proliferation in a mixed lymphocyte reaction. Read More

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November 2018

Innervation of the entire internal anal sphincter in a mouse model of Hirschsprung's disease: a first report.

Pediatr Surg Int 2018 Nov 9. Epub 2018 Nov 9.

Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Impaired function of the internal anal sphincter (IAS) may be implicated in postoperative obstructed defecation (POD) that may complicate Hirschsprung's disease (HD) patients. While innervation of part of the IAS in HD has been reported, accurate details based on anatomic landmarks that can explain the clinical morbidity seen in POD are lacking, and there appear to be no studies that specifically document the innervation of the "entire" IAS in HD. We used endothelin receptor-B knockout mice to represent HD (HD-mice) and C57B6 wild mice as controls (C-mice) to investigate the innervation of the entire IAS to assess the pathophysiology of POD experimentally. Read More

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November 2018
3 Reads

Cryptic binding sites become accessible through surface reconstruction of the type I collagen fibril.

Sci Rep 2018 Nov 9;8(1):16646. Epub 2018 Nov 9.

Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, 08854, USA.

Collagen fibril interactions with cells and macromolecules in the extracellular matrix drive numerous cellular functions. Binding motifs for dozens of collagen-binding proteins have been determined on fully exposed collagen triple helical monomers. However, when the monomers are assembled into the functional collagen fibril, many binding motifs become inaccessible, and yet critical cellular processes occur. Read More

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November 2018
2 Reads

Stillbirth among women in nine states in India: rate and risk factors in study of 886,505 women from the annual health survey.

BMJ Open 2018 Nov 8;8(11):e022583. Epub 2018 Nov 8.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Objectives: To assess the rate of stillbirth and associated risk factors across nine states in India.

Design: Secondary analysis of cross-sectional data from the Indian Annual Health Survey (2010-2013).

Setting: Nine states in India: Madhya Pradesh, Chhattisgarh, Rajasthan, Uttarakhand, Jharkhand, Odisha, Bihar, Assam and Uttar Pradesh. Read More

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November 2018
6 Reads

Conservative management of septic complication after internal Delorme procedure for occult rectal prolapse and rectocele in obstructed defecation syndrome.

Tech Coloproctol 2018 Oct 8;22(10):817-818. Epub 2018 Nov 8.

Proctology Clinic, Private Hospitals in Forlì, Forlì, Italy.

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October 2018
1 Read

FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis.

Sci Rep 2018 Nov 8;8(1):16529. Epub 2018 Nov 8.

Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Cholestasis impairs liver regeneration following partial liver resection (PHx). Bile acid receptor farnesoid X-receptor (FXR) is a key mediator of liver regeneration. The effects of FXR agonist obeticholic acid (OCA) on liver (re)growth were therefore studied in cholestatic rats. Read More

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November 2018
3 Reads

Development of Wheat With Hypoimmunogenic Gluten Obstructed by the Gene Editing Policy in Europe.

Front Plant Sci 2018 18;9:1523. Epub 2018 Oct 18.

Plant Breeding, Wageningen University & Research, Wageningen, Netherlands.

Coeliac Disease (CD) is an auto-immune reaction to gluten in 1-2% of the human population. A gluten-free (GF) diet, excluding wheat, barley, and rye, is the only remedy. This diet is difficult to adhere to, partly because wheat gluten is added to many processed products for their viscoelastic properties. Read More

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October 2018
4 Reads

IL-17 Receptor Signaling Negatively Regulates the Development of Tubulointerstitial Fibrosis in the Kidney.

Mediators Inflamm 2018 14;2018:5103672. Epub 2018 Oct 14.

Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Chronic inflammation has an important role in the development and progression of most fibrotic diseases, for which no effective treatments exist. Tubulointerstitial fibrosis (TF) is characterized by irreversible deposition of fibrous tissue in chronic kidney diseases. Prolonged injurious stimuli and chronic inflammation regulate downstream events that lead to TF. Read More

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October 2018
5 Reads

Laparoscopic treatment of obstructed internal supravesical hernia: A cases series and rewiev of the literature.

Ann Med Surg (Lond) 2018 Dec 23;36:58-62. Epub 2018 Oct 23.

Department of Applied Clinical Science and Biotechnology, University of L'Aquila, Via Vetoio, 67100, L'Aquila, AQ, Italy.

Introduction: internal supravesical hernia (ISH) is an exceptional subtype of internal hernia often presenting with small bowel obstruction (SBO). Its rarity makes preoperative suspicion and diagnosis very difficult in an emergency setting.

Methods: we retrospectively analyzed the database of patients admitted in a single center emergency unit for small bowel occlusion (SBO) in virgin abdomen and treated by surgery from August 2013 to October 2018. Read More

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December 2018
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Use of a subcutaneous ureteral bypass device for treatment of benign ureteral obstruction in cats: 174 ureters in 134 cats (2009-2015).

J Am Vet Med Assoc 2018 Nov;253(10):1309-1327

OBJECTIVE To determine outcomes of subcutaneous ureteral bypass (SUB) device placement for treatment of benign ureteral obstruction in cats. DESIGN Retrospective case series. ANIMALS 134 cats with SUB devices placed in 174 obstructed ureters during 144 hospitalizations. Read More

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November 2018
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A road to bring Brij52 back to attention: Shear stress sensitive Brij52 niosomal carriers for targeted drug delivery to obstructed blood vessels.

Med Hypotheses 2018 Dec 10;121:137-141. Epub 2018 Sep 10.

Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; School of Pharmacy and Pharmaceutical Sciences, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

Thrombosis is a shared perpetrating event in the pathophysiology of several cardiovascular disorders such as ischemic stroke, venous thromboembolism, atherosclerosis, and myocardial infarction. Despite holding a wide range of ammunition in our arsenal to ameliorate such conditions, we are still facing with many stumbling blocks in the satisfactory pharmacotherapy of cardiovascular diseases among which the risk of hemorrhage and life threatening drug interactions can be highlighted. Our hypothesis focuses on mimicking the nature of platelet activation, to design a novel targeted delivery system based on the alterations of a physical parameter, the hemodynamic shear stress, to aim at the offending thrombi in an attempt to offer a noninvasive, rapid, and monitoring-free method that not only can prolong the circulation time of the cargo, but also deliver it locally and reduce both the undesirable adverse effects and drug interactions. Read More

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December 2018
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[Chinese guidelines for ERCP (2018)].

Authors:

Zhonghua Nei Ke Za Zhi 2018 Nov;57(11):772-801

Endoscopic retrograde cholangiopancreatography (ERCP) was reported for the first time in 1970s. Since then, ERCP has become an indispensable procedure in the diagnosis and management of a variety of biliary and pancreatic disorders. The main purpose of Chinese ERCP guideline is to precisely define the clinical indications of ERCP. Read More

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November 2018
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Transition of care: a growing concern in adult patients born with colorectal anomalies.

Pediatr Surg Int 2018 Nov 3. Epub 2018 Nov 3.

Department of Pediatric Surgery, International Center for Colorectal and Urogenital Care, Children's Hospital Colorado, University of Colorado, 13123 East 16th Avenue, Anschutz Medical Campus, Box 323, Aurora, CO, 80045, USA.

Purpose: Traditionally, the care of children and adults has been arbitrarily separated into pediatric and adult medicine and surgery. Despite progress in pediatric surgical techniques, patients born with congenital anomalies still suffer from significant functional sequelae, which persist into adulthood. We aim to describe some of the most common problems experienced by adult patients with congenital colorectal malformations. Read More

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November 2018
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