292,403 results match your criteria Obstetrics and gynecology[Journal]
Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.
Department of Obstetrics and Gynecology, Galilee Medical Center, Nahariya, Israel.
Objective: Frozen section examination is a rapid method for identifying products of conception in endometrial curetting, yet its accuracy is inconclusive. The purposes of this study is to determine the accuracy of frozen section analysis of endometrial curetting in pregnancies of unknown location, and to verify the relation of β-human chorionic gonadotrophin (hCG) level and endometrial thickness to the assessed accuracy.
Methods: We reviewed data from January 2009 to December 2014 of diagnostic curettages from women with suspected ectopic pregnancies sent for frozen section examination at a medical center. Read More
Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.
Group of Research in Nutrition and Chronic Diseases, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
Objective: To assess the association between dietary glycemic index (GI) and excess weight in pregnant women in the first trimester of pregnancy.
Methods: A cross-sectional study in a sample of 217 pregnant women was conducted at the maternal-fetal outpatient clinic of the Hospital Geral de Fortaleza, Fortaleza, state of Ceará, Brazil, for routine ultrasound examinations in the period between 11 and 13 weeks + 6 days of gestation. Weight and height were measured and the gestational body mass index (BMI) was calculated. Read More
Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.
Universidade Positivo, Curitiba, PR, Brazil.
Renal artery aneurysms (RAAs) are rare and usually asymptomatic; ∼ 90% of them are unilateral. Once diagnosed during pregnancy, they may rupture, presenting a high maternal-fetal risk. The present study reports the case of a 32-year-old pregnant woman with a 30-week gestational age and a ruptured unilateral RAA. Read More
Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.
Section of Obstetrics and Gynecology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Müllerian adenosarcoma is a very rare gynecological disease, comprising 5% of uterine sarcomas. Extragenital localizations are even rarer. We report a very interesting case of a 27-year-old woman complaining of pelvic pain, with a subsequent diagnosis of extragenital Müllerian adenosarcoma. Read More
J Clin Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.
Department of Physiology and Biophysics, University of Illinois at Chicago.
Context: The role of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) on aromatase regulation is poorly understood in humans.
Objective: Determine GDF9 and BMP15 effects on follicle-stimulating hormone (FSH) stimulation of estradiol production in primary human cumulus granulosa cells (GCs). We hypothesized that the combination of GDF9 and BMP15 potentiates FSH-induced aromatase expression. Read More
J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.
Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More
Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.
Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Kettegård Allé 26, Hvidovre, Denmark.
Study Question: Is the number of aspirated oocytes in the first ART cycle associated with the cumulative live birthrates (CLBR) in subsequent cycles?
Summary Answer: The number of aspirated oocytes in the first cycle was associated with CLBR in subsequent cycles. Previous treatment response predicts outcome in future cycles.
What Is Known Already: Previous reports have shown a positive association between the number of retrieved oocytes and live birthrate per fresh treatment cycle. Read More
Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.
Department of Clinical Genetics, Yokohama City University Hospital, Yokohama, Japan.
Background: Application of next-generation DNA sequencing (NGS) has recently become increasingly common in the field of clinical oncology in several countries around the world. In Japan also, a system for applying NGS to routine clinical practice is gradually being established. During this process, we introduced in Japan the tumor-profiling MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) assay. Read More
Horm Res Paediatr 2018 Dec 12:1-9. Epub 2018 Dec 12.
Department of Pediatric Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.
Background: Hair glucocorticoids (GCs) offer a retrospective view on chronic GC exposure. We assessed whether maternal pre- and postnatal stress was associated with neonatal and maternal hair GCs postpartum (pp).
Methods: On the first day pp 172 mother-infant pairs donated hair, of whom 67 had consulted a centre of expertise for psychiatric disorders during pregnancy. Read More
Psychother Psychosom 2018 Dec 12:1-3. Epub 2018 Dec 12.
Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan.
Int Immunopharmacol 2018 Dec 9;67:106-118. Epub 2018 Dec 9.
Department of Immunology, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China; Key Laboratory of Tumor Prevention and Treatment of Heilongjiang Province, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China; Institute of Neural Tissue Engineering, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China. Electronic address:
Macrophages are highly plastic cells. Depending on stimulation, macrophages rapidly polarize to functionally distinct phenotypes that are involved in the pathogenesis of inflammatory bowel disease (IBD). 1,25‑Dihydroxyvitamin D (1,25(OH)D) has immunomodulatory activity, and 1,25(OH)D deficiency is correlated with autoimmune diseases, especially IBD. Read More
PLoS One 2018 12;13(12):e0207986. Epub 2018 Dec 12.
Department of Public Health Sciences, Global Health (IHCAR), Karolinska Institutet, Stockholm, Sweden.
Background: Male partner participation improves uptake, retention and outcomes of prevention of mother-to-child transmission of HIV (PMTCT) services. However, in patriarchal settings few men accompany their partners to antenatal care (ANC) and PMTCT services. We explored whether community leaders can improve male partner participation in ANC and PMTCT. Read More
PLoS One 2018 12;13(12):e0207699. Epub 2018 Dec 12.
Department of Obstetrics and Gynaecology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Objective: To identify the risk factors for ectopic pregnancy (EP) in a population of Cameroonian women.
Sample And Methods: We performed a matched case-control study; 88 women with diagnosed EP (cases), and 176 women with first trimester intrauterine pregnancy (IUP) (controls), who underwent questionnaires. Odds Ratio (OR) and 95% confidence intervals (CIs) were calculated and adjusted for potential confounding factors via multivariate logistic regression analysis. Read More
J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.
Hypertension & Vascular Research, Cardiovascular Sciences Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157.
Hypertensive transgenic (mRen2)27 rats exhibit impaired baroreflex sensitivity (BRS) for control of heart rate (HR). Intracerebroventricular (ICV) infusion of Ang-(1-7) improves indices of vagal BRS independent of lowering mean arterial pressure (MAP), while AT1 receptor blockade normalizes MAP and indices of sympathetic tone without correcting the vagal BRS. Scavenging cellular reactive oxygen species (ROS) with tempol in brain fails to correct either hypertension or sympathovagal balance in these animals, despite reports that mitochondrial ROS contributes to Ang II-infusion hypertension. Read More
Ann Plast Surg 2019 Jan;82(1S Suppl 1):S6-S12
Department of Orthopedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
De Quervain's disease is a stenosing tenosynovitis of the first dorsal compartment of the wrist. Histopathological studies have reported that the thickening of the first dorsal retinaculum is characterized by degeneration rather than inflammation. However, significant infiltration of mast cells and macrophages was noted in a torn tendon study, which suggested that innate immune pathways are part of the mechanism that mediates early tendinopathy. Read More
Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.
Department of Gynecology and Obstetrics, Düsseldorf University Hospital, Düsseldorf, Germany.
Purpose Of Review: The possibility of tumor dissemination through the blood system has been known for years. Circulating tumor cells (CTCs) are detectable in the peripheral blood of patients with early as well as metastatic breast cancer. The prognostic relevance of this biomarker has already been described. Read More
Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Women's Cancer Center, Stanford University School of Medicine, Stanford, California, USA.
Purpose Of Review: To provide an update on cell-based immunotherapies in solid tumors particularly in gynecological cancers.
Recent Findings: Improvements have been made in engineering T cells to overcome the immunosuppressive environment in ovarian cancer. Significant efforts are underway to create 'off the shelf' cell therapies which leverage natural killer (NK) cells and would not rely on engineering a patient's T cells. Read More
Physiol Rev 2019 Jan;99(1):739-780
Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.
Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More
Chin Med J (Engl) 2018 Dec;131(24):3012-3014
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing 100730, China.
J Cancer Res Ther 2018 Dec;14(Supplement):S1209-S1212
Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Uterine tumors resembling ovarian sex-cord tumor (UTROSCT) are a rare, multi-phenotype sex-cord tumors, containing a structure which is characteristic with the trabecular, cord, nests, and false adenoid arrangement. In addition, CD99-positive was a basis for diagnosis of the disease. With uncertain malignant potential and relapse, these patients should be closely followed up. Read More
J Cancer Res Ther 2018 Dec;14(Supplement):S1193-S1200
Department of Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India.
Background: Nuclear factor kappa B (NFkB-light-chain-enhancer of activated B-cells) expression and its regulation is a key role in the development of number of malignancies, as NFkB mediates the balance between cell death and its survival. Therefore, NFkB regulation constitutes an attractive target to overcome the resistance to chemotherapeutic agents in anticancer therapy. Curcumin, as a chemopreventive agent, has a potential role in inhibiting cell growth in a variety of malignancies. Read More
J Cancer Res Ther 2018 Dec;14(Supplement):S1063-S1069
Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Al Menoufia, Egypt.
Background: Programmed death-ligand 1 (PD-L1) and hypoxia-inducible factor-1α (HIF-1α) proteins mediate major alterations of tumor microenvironment including generation of immunosuppressive microenvironment and tumor hypoxia, respectively. These alterations play a crucial role in carcinogenesis and tumor progression.
Aims: The present study was designed to investigate the correlation between the expression of PD-L1 and HIF-1α proteins and the clinicopathologic variables in endometrial carcinoma. Read More
J Cancer Res Ther 2018 Dec;14(Supplement):S1057-S1062
Department of Internal Medicine of TCM, Zhonglu Hospital, Shandong University of TCM, Jinan, Shandong Province, China.
Objective: The objective of this paper was to investigate differential pathways in sporadic amyotrophic lateral sclerosis (SALS) based on pathway network analysis.
Materials And Methods: To achieve this goal, first, differentially expressed genes (DEGs) between SALS and normal controls were identified, and a target network was defined as DEGs correlated interactions from the search tool for the retrieval of interacting genes/proteins (STRING). Second, topological centrality analysis was conducted on the target network to identify hub genes and hub network. Read More
J Obstet Gynaecol Can 2018 Dec 24;40(12):1627-1631. Epub 2018 Oct 24.
Faculty of Medicine, Dalhousie University, Halifax, NS; Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, NS.
We discuss the management of GBS positive women with PPROM, an aspect of obstetrical management that remains controversial despite the publication of new randomized control trials in recent years. Clinical practice guidelines from several countries' national organizations are compared and contrasted, and areas of uncertainty are identified. Read More
J Obstet Gynaecol Can 2018 Dec 26;40(12):1608-1617. Epub 2018 Oct 26.
BORN (Better Outcomes Registry and Network) Ontario, Ottawa, ON; Ottawa Hospital Research Institute, Ottawa, ON; OMNI Research Group, Ottawa, ON; CHEO (Children's Hospital of Eastern Ontario) Research Institute, Ottawa, ON; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON.
Objective: The objectives of this study were as follows: (1) to investigate the accuracy of IVF identification on the prenatal screening record from prenatal screening laboratories; (2) to compare the screening markers in IVF and non-IVF pregnancies in the population of Ontario; and (3) to propose more appropriate IVF adjustment factors for the Ontario population.
Methods: Two years of IVF treatment, data from all fertility clinics in Ontario were merged with the corresponding prenatal screening data from all five prenatal screening labs. New adjustment factors for IVF were developed for each maternal serum screening marker and nuchal translucency measurement. Read More
Reprod Biomed Online 2018 Nov 6;37(5):573-580. Epub 2018 Oct 6.
Unit for Human Reproduction, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece. Electronic address:
The use of testicular spermatozoa in men without azoospermia has been proposed as a means to increase the chances of pregnancy following assisted reproductive treatment. The purpose of this systematic review is to assess whether clinical outcomes are better when testicular rather than ejaculated spermatozoa are used for intracytoplasmic sperm injection in patients with abnormal semen parameters without azoospermia. A literature search identified four eligible studies out of 757 initially found. Read More
J Womens Health (Larchmt) 2018 Dec 8. Epub 2018 Dec 8.
1 Women's Health Research Institute, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
Objective: On January 25th, 2016, the National Institutes of Health (NIH) implemented a policy requiring investigators to consider sex as a biological variable (SABV) within their grant submissions. We surveyed NIH study section members in 2016 and 2017 to determine their attitudes toward the policy and their perceptions regarding its implementation.
Materials And Methods: Members of standing study sections and special emphasis panels who met in May, June, or July of 2016 and 2017, and had a publicly accessible e-mail address, were invited to participate in the survey (n = 4376 and n = 4710, respectively). Read More
Ups J Med Sci 2018 Dec 12:1-7. Epub 2018 Dec 12.
d Department of Public Health , University of Copenhagen , Copenhagen , Denmark.
Introduction: Over the past 50 years women and men have postponed family formation in high-income societies. Fertility assessment and counselling has been suggested as a method to reduce delayed childbearing and its consequences. This study explored women's perceptions of how attending a fertility assessment intervention influenced their decisions and choices regarding family formation and childbearing. Read More
Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.
Gynaecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Prague, Czech Republic.
Purpose: To evaluate morbidity and oncological outcome in a multicentre series of women with gynaecological malignancies infiltrating pelvic side wall (PSW) that received laterally extended pelvic resection (LEPR).
Methods: Patients operated between 2007 and 2017 at three institutions were included. LEPR was defined as an en bloc lateral resection of a pelvic tumour involving sidewall muscle, and/or bone, and/or major nerve, and/or major vascular structure. Read More
Matern Child Health J 2018 Dec 11. Epub 2018 Dec 11.
The California Preterm Birth Initiative, University of California, San Francisco, San Francisco, CA, USA.
Objective Evaluate risk of preterm birth (PTB, < 37 completed weeks' gestation) among a population of women in their second pregnancy with previous full term birth but other adverse pregnancy outcome. Methods The sample included singleton live born infants between 2007 and 2012 in a birth cohort file maintained by the California Office of Statewide Health Planning and Development. The sample was restricted to women with two pregnancies resulting in live born infants and first birth between 39 and 42 weeks' gestation. Read More
Arch Gynecol Obstet 2018 Dec 11. Epub 2018 Dec 11.
Department of Obstetrics and Gynecology, School of Medicine, University of Campinas, Rua Alexander Fleming 101, Campinas, São Paulo, 13083-891, Brazil.
Purpose: To assess the association between maternal potentially life-threatening conditions (PLTC), maternal near miss (MNM), and maternal death (MD) with perinatal outcomes.
Methods: Cross-sectional study in 27 Brazilian referral centers from July, 2009 to June, 2010. All women presenting any criteria for PLTC and MNM, or MD, were included. Read More
J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.
Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA.
Purpose: Following radiation therapy (RT), women with gynecologic malignancies report high rates of sexual dysfunction, but little is known regarding sexual health communication between these patients and health-care providers. This study assessed these patients' beliefs/attitudes toward providers' sexual history taking.
Methods: Surveys were administered to women who presented for follow-up care for gynecologic cancers in an academic radiation oncology department. Read More
Virusdisease 2018 Dec 3;29(4):537-539. Epub 2018 Aug 3.
1Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104 Karnataka India.
Once the recommended 5-year recurrence-free follow-up is achieved for cervical cancers regular annual pelvic examination is mandatory. The main aim of presenting this short report is to emphasize the difficulties in the collection and interpretation of cytology samples from stenosed cervix or vault after pelvic irradiation. Radiotherapy can induce changes in the cellular morphology which may persist for many years. Read More
Biomed Res Int 2018 13;2018:5714890. Epub 2018 Nov 13.
Department of Obstetrics and Gynecology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Objective: To explore the epidemiological aspects, to describe the frequency and distribution of WHO maternal near miss (MNM) criteria and the presence of organ dysfunction and failure measured by the maximum SOFA (Sequential Organ Failure Assessment) score (SOFA max) in cases of severe maternal outcome (SMO).
Methods: In an observational cross-sectional study performed between January 2013 and December 2015, 279 pregnant or postpartum women were admitted to an obstetric ICU (intensive care unit) in Brazil. MNM, maternal death (grouped as SMO), and potentially life-threatening conditions (PLTC) were defined according to WHO criteria. Read More
Biomed Res Int 2018 13;2018:5042707. Epub 2018 Nov 13.
EKO Children's Hospital, Oberhausen, Witten/Herdecke University, Germany.
The importance for mortality and morbidity of an in-house pediatric surgery unit for premature infants with necrotizing enterocolitis (NEC) remains undefined. Data on 389 consecutive very low birth weight infants with a birth weight <1250 g admitted between 2009 and 2014 was retrospectively analyzed in two almost identical neonatal intensive care units. Epidemiological data (n=172 and n=217, respectively) were comparable. Read More
Front Pediatr 2018 27;6:359. Epub 2018 Nov 27.
Center for Pediatrics, Department of Neonatology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Human milk (HM) for preterm infants will often be pasteurized for cytomegalovirus (CMV) inactivation and reduction of its bacterial count. High-temperature short-time (HTST) treatment compared to standard Holder pasteurization (HoP) reduces the impact of heat treatment on bioactive HM proteins while effectively inactivating CMV. No data are available for the efficacy of bacterial count reduction using HTST treatments that are available for clinical use. Read More
Clin Exp Reprod Med 2018 Dec 30;45(4):189-194. Epub 2018 Nov 30.
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Objective: The aim of this study was to compare the rate of maturation, fertilization, and embryo development of -matured human oocytes derived from pregnant and non-pregnant women.
Methods: Immature oocytes were obtained by needle aspiration from 49 pregnant women (group 1) who underwent a cesarean section at term and 77 non-pregnant women (group 2) who underwent a gynecological operation during the same period (8 months). Healthy immature oocytes (530 in group 1 and 539 in group 2) were cultured and assessed for maturation 36 hours later. Read More
Clin Exp Reprod Med 2018 Dec 30;45(4):183-188. Epub 2018 Nov 30.
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
Objective: The purpose of this retrospective study was to evaluate the appropriateness of various follicle-stimulating hormone (FSH) starting doses in expected normal responders based on the nomogram developed by La Marca et al.
Methods: A total of 117 first fertilization cycles performed from 2011 to 2017 were selected. All women were expected normal responders and used a recombinant FSH and flexible gonadotropin-releasing hormone antagonist protocol. Read More
Clin Exp Reprod Med 2018 Dec 30;45(4):149-153. Epub 2018 Nov 30.
Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
Stem cells are undifferentiated cells capable of self-renewal and differentiation into various cell lineages. Stem cells are responsible for the development of organs and regeneration of damaged tissues. The highly regenerative nature of the human endometrium during reproductive age suggests that stem cells play a critical role in endometrial physiology. Read More
Lupus Sci Med 2018 21;5(1):e000293. Epub 2018 Nov 21.
Department of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland.
Background: SLE is an autoimmune condition affecting predominantly women. Little is known regarding infection in women with SLE, which may drive autoimmunity and contribute to obstetrical and vascular complications.
Methods: This single-centre, case-control study set primary endpoint in the comparative seropositivity rate to major outer membrane protein (MOMP) and chlamydial heat-shock protein-60 (cHSP60) in age-matched subjects. Read More
EPMA J 2018 Dec 12;9(4):403-419. Epub 2018 Nov 12.
1Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
In contrast to the genetic component in mammary carcinogenesis, epigenetic alterations are particularly important for the development of sporadic breast cancer (BC) comprising over 90% of all BC cases worldwide. Most of the DNA methylation processes are physiological and essential for human cellular and tissue homeostasis, playing an important role in a number of key mechanisms. However, if dysregulated, DNA methylation contributes to pathological processes such as cancer development and progression. Read More
Nucl Med Mol Imaging 2018 Dec 11;52(6):445-452. Epub 2018 Oct 11.
1Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 South Korea.
Purpose: This study aimed to compare the diagnostic value of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and magnetic resonance imaging (MRI) in the preoperative evaluation of uterine carcinosarcoma.
Methods: Fifty-four women with pathologically confirmed uterine carcinosarcoma who underwent preoperative FDG PET/CT and MRI from June 2006 to November 2016 were included. Pathologic findings from primary tumor lesions, para-aortic and pelvic lymph node (LN) areas, and peritoneal seeding lesions were compared with the FDG PET/CT and MRI findings. Read More
Int J Endocrinol 2018 14;2018:7234543. Epub 2018 Nov 14.
Department of Woman and Child Health, University of Padua, Padua, Italy.
Front Endocrinol (Lausanne) 2018 27;9:696. Epub 2018 Nov 27.
Division of Obstetrics and Feto-Maternal Medicine, Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.
This review serves to evaluate the screening and diagnostic strategies for gestational diabetes and overt diabetes in pregnancy. We focus on the different early screening and diagnostic approaches in first trimester including fasting plasma glucose, random plasma glucose, oral glucose tolerance test, hemoglobin A1c, risk prediction models and biomarkers. Early screening for gestational diabetes is currently not recommended since the potential benefits and harms of early detection and subsequent treatment need to be further evaluated in randomized controlled trials. Read More
Cancer Manag Res 2018 23;10:6195-6204. Epub 2018 Nov 23.
Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China,
Background: S1 is a novel BH3 mimetic that can induce death in some types of cancer cells, such as melanoma B16, ovarian cancer SKOV3, and U251 glioma cells. S1 inhibits Bcl-2 and Mcl-1 expression and induces cancer cell apoptosis. Cancer cell survival is highly dependent on glucose. Read More
Cancer Manag Res 2018 22;10:6029-6038. Epub 2018 Nov 22.
Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw 02-781, Poland.
Objective: Our study assessed the clinical utility and prognostic value of pretreatment hematological parameters and calculated coefficients including the platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and monocyte to lymphocyte ratio (MLR) in patients with cervical adenocarcinoma (CA).
Materials And Methods: Among 738 cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stages IA-IV treated at our institution, 96 (13%) presented with CA histology. The blood samples, collected within 10 days before treatment, were analyzed using a Sysmex XN-2000 system. Read More
Cancer Manag Res 2018 20;10:5965-5978. Epub 2018 Nov 20.
Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,
Background: Systemic chemotherapy is the standard treatment for locally advanced and metastatic pancreatic cancer, but there is no consensus on the optimum regimen. We aimed to compare and rank the locally advanced and metastatic pancreatic adenocarcinoma chemotherapy regimens evaluated in randomized controlled trials (RCTs) in the past 15 years.
Materials And Methods: PubMed, Embase, Cochrane Collaboration database, and ClinicalTrials. Read More
Diabetes Metab Syndr Obes 2018 26;11:827-834. Epub 2018 Nov 26.
Department of Gynaecology and Obstetrics, Beijing Key Laboratory of Cancer Therapeutic Vaccine, Beijing 100038, China,
Purpose: Kupffer cells (KCs) present dysfunctional immunity capacity among the diabetes mellitus patients. This study aims to investigate whether Lidocaine could reverse dysfunctions of KCs, in terms of phagocytosis, granulocyte recruitment and inflammatory mediator secretion.
Methods: db/db and C57BL/6 mice were employed to establish diabetic and nondiabetic models. Read More
Indian J Surg Oncol 2018 Dec 20;9(4):618-621. Epub 2018 Jul 20.
1Department of Obstetrics and Gynaecology, K.S. Hegde Medical Academy, Mangalore, 575018 India.
The ovary is a common site of metastasis from various organs. However, little is known about gallbladder carcinoma metastasising to the ovaries and presenting as a primary ovarian tumour. We report a case of a metastatic gallbladder carcinoma which mimicked a primary ovarian tumour in a 31-year-old woman who presented with menstrual symptoms and an ovarian mass without obvious signs and symptoms related to gallbladder carcinoma. Read More