292,090 results match your criteria Obstetrics and Gynecology Clinics of North America [Journal]
Planta Med 2018 Dec 6. Epub 2018 Dec 6.
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Leaves of the plant are traditionally consumed for bone health and other indications. The aim of this study was to establish the safety and pharmacokinetics of the metabolites of prenylflavonoids (icariin, icariside I, icariside II, icaritin, and desmethylicaritin) following single doses of a defined prenylflavonoid extract in humans. A single oral dose of 370, 740, or 1110 mg of a standardized prenylflavonoid extract was administered to 30 healthy male subjects in a randomized, placebo-controlled trial. Read More
Dement Geriatr Cogn Disord 2018 Dec 6;46(5-6):346-357. Epub 2018 Dec 6.
Oslo Delirium Research Group, Department of Geriatric Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury.
Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Read More
Cell Physiol Biochem 2018 Dec 6;51(5):2030-2040. Epub 2018 Dec 6.
Department of Obstetrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing,
Background/aims: Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion.
Methods: LN-α5 expression levels were examined by reverse-transcriptase polymerase chain reaction (RT-PCR), and further confirmed by western blotting and immunofluorescence staining. Read More
Toxicol Appl Pharmacol 2018 Dec 3. Epub 2018 Dec 3.
Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States. Electronic address:
Pregnant women with epilepsy (PWWE) require continuous anti-epileptic drug (AED) treatment to avoid risk to themselves and fetal risks secondary to maternal seizures, resulting in prolonged AED exposure to the developing embryo and fetus. The objectives of this study were to determine whether high-resolution metabolomics is able to link the metabolite profile of PWWE receiving lamotrigine or levetiracetam for seizure control to associated pharmacodynamic (PD) biological responses. Untargeted metabolomic analysis of plasma obtained from 82 PWWE was completed using high-resolution mass spectrometry. Read More
Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas.
Background: Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus. We demonstrated previously that offspring born to pregnant mice lacking endothelial nitric oxide synthase (eNOS+/-) gene have hypertension (HTN) as adults and when fed high fat diet (HFD) develop a metabolic syndrome (MS) phenotype.
Objective: Our aim was to evaluate if INOs treatment in pregnancy complicated by MS improves the vascular and metabolic profile in mice offspring programmed in utero to develop HTN and MS. Read More
Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.
Northwestern University, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chicago, IL, USA; Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; Center for Healthcare Studies, Institute for Public Health in Medicine, Chicago, IL.
Background: In patients with endometrial cancer sentinel lymphadenectomy is used to accurately prognosticate extent of disease and has been proposed as a method to decrease the incidence of medical and surgical complications associated with more extensive lymphadenectomy. It is unknown if patients who undergo traditional lymphadenectomy experience major postoperative complications at the same rates as those who undergo sentinel lymphadenectomy or those who do not undergo lymphadenectomy.
Objective: To compare the incidence of major postoperative complications among endometrial cancer patients undergoing total laparoscopic hysterectomy with traditional lymphadenectomy versus sentinel or no lymphadenectomy. Read More
Cochrane Database Syst Rev 2018 Dec 4;12:CD009458. Epub 2018 Dec 4.
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, Section Three, Ren Min Nan Lu Avenue, Chengdu, Sichuan, China, 610041.
Background: Endometrial carcinoma is the most common gynaecologic malignancy in the world and develops through preliminary stages of endometrial hyperplasia. Atypical endometrial hyperplasia suggests a significant pre-malignant state with frank progression to endometrial carcinoma, and tends to occur at a young age. Oral progestins have been used as conservative treatment in young women with atypical endometrial hyperplasia, but they are associated with poor tolerability and side effects that may limit their overall efficacy. Read More
PLoS One 2018 6;13(12):e0208576. Epub 2018 Dec 6.
Department of Reproductive Medicine & Fertility Preservation, Hôpital Jean Verdier, Bondy, France.
In vitro maturation (IVM) of oocytes retrieved at germinal vesicle or Metaphase I stage, followed by vitrification of Metaphase II (MII) oocytes, has recently emerged as an option for urgent fertility preservation (FP). Priming is usually achieved with an injection of hCG, 10,000 IU, 36 hours before retrieval. This study aimed to assess a new method of priming, using GnRH agonists, and compare it to hCG, in cancer patients undergoing urgent FP. Read More
PLoS One 2018 6;13(12):e0208485. Epub 2018 Dec 6.
Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Iron deficiency anemia (IDA) is a common micronutrient deficiency worldwide, and an important health problem especially in women of reproductive age. This study aimed to determine the relationship between IDA and sexual satisfaction and function among reproductive-aged Iranian women. In this study, 129 women (52 with IDA and 77 non-IDA) with age 18-45 in Mahshahr, Iran were recruited. Read More
PLoS One 2018 6;13(12):e0208508. Epub 2018 Dec 6.
Department of Research and Development, CFGenome Omaha NE, United States of America.
This study was undertaken to evaluate a novel method for stabilizing and preserving the original proportion of cell-free fetal DNA (cffDNA) in maternal blood for extended periods of time without using crosslinking agents, such as formaldehyde, which compromise DNA integrity and extraction efficiency. Blood was drawn from pregnant donors into K3EDTA and Blood Exo DNA ProTeck® (ProTeck) tubes. Blood drawn into both tubes were aliquoted and stored at three different temperatures. Read More
PLoS One 2018 6;13(12):e0208531. Epub 2018 Dec 6.
Department of Strategic Information and Research, Institute of Human Virology Nigeria, Abuja, Nigeria.
Objective: In low resource settings, visual inspection with acetic acid (VIA) by allied health workers, has been suggested as an alternative for cervical cancer screening. However, there are concerns about the objectivity and time to diagnostic concordance with specialists. We evaluated the secular trend in interobserver agreement between nurse providers and a gynecologist/colposcopist over a five-year period. Read More
PLoS One 2018 6;13(12):e0208299. Epub 2018 Dec 6.
Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.
Pakistani women suffer the highest rate of maternal mortality in South Asia. A lack of comprehensive knowledge about maternal and newborn health (MNH) services costs impedes policy decisions to maximize the benefit from existing, as well as emerging, MNH interventions in Pakistan. We compared MNH service costs at different levels of care. Read More
PLoS One 2018 6;13(12):e0208221. Epub 2018 Dec 6.
Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.
The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN and MMR) previously suggested to be involved in the pathogenesis of endometrial cancer, in association with clinical outcome and standard clinicopathological characteristics. A total of 204 patients with histological diagnosis of endometrial cancer treated from 2004 to 2013 were included. The evaluation of protein expression was assessed by immunohistochemistry. Read More
PLoS One 2018 6;13(12):e0207392. Epub 2018 Dec 6.
Sanbo Brain Institute, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Background: Insomnia is one of the main symptoms of sleep disorders. Previous studies have suggested that alcohol intake is associated with several adverse health outcomes. The association between alcohol consumption and insomnia has been addressed in several studies with different results. Read More
PLoS One 2018 6;13(12):e0207950. Epub 2018 Dec 6.
Gynecological Endocrinology and Reproductive Medicine, Medical University Innsbruck, Innsbruck, Austria.
Introduction: Extracellular vesicles (EV) are shed from a broad variety of cells and play an important role in activation of coagulation, cell to cell interaction and transport of membrane components. They are usually measured as circulating EV in peripheral blood (PB) and other body fluids. However, little is known about the distribution, presence and impact of EV and their subpopulations in bone marrow (BM). Read More
PLoS One 2018 6;13(12):e0206053. Epub 2018 Dec 6.
Department of Gynecological Endocrinology and Fertility Disorders, University of Heidelberg, Heidelberg, Germany.
Background: Local anesthetics (LAs) are increasingly used as therapeutics due to their multiple molecular effects. They may be potential agents also in gynecology and reproductive medicine. The objective of this study was to investigate the contractility response of the perfused swine uterus to different concentrations of the LAs procaine, lidocaine, and ropivacaine. Read More
Folia Med Cracov 2018 ;58(3):89-102
Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland.
Introduction: Uterine leiomyoma is the most widespread benign tumor affecting women of childbearing age. ere are still gaps in the understanding of its pathogenesiss. Telocytes are unique cells described in greater than 50 different locations inside the human body. Read More
Med Sci Monit 2018 Dec 6;24:8831-8839. Epub 2018 Dec 6.
Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
BACKGROUND Epithelial ovarian cancer (EOC) has a high mortality rate and is a common malignant tumor of women, seriously impairing health. Chemoresistance is one of the major causes of poor prognosis. Therefore, analyzing the molecular mechanism of paclitaxel resistance has great significance. Read More
Epigenetics 2018 Dec 6. Epub 2018 Dec 6.
b Department of Psychiatry and Behavioral Sciences , Duke University Medical Center , Durham . NC 27705 , USA.
Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measured by reduced representation bisulfite sequencing, differed in the sperm of human users from non-users by at least 10% at 3,979 CpG sites. Read More
FASEB J 2018 Dec 6:fj201802037R. Epub 2018 Dec 6.
Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA.
The placenta plays a pivotal role in the development of the fetal brain and also influences maternal brain function, but our understanding of communication between the placenta and brain remains limited. Using a gene expression and network analysis approach, we provide evidence that the placenta transcriptome is tightly interconnected with the maternal brain and fetal brain in d 15 pregnant C57BL/6J mice. Activation of serotonergic synapse signaling and inhibition of neurotrophin signaling were identified as potential mediators of crosstalk between the placenta and maternal brain and fetal brain, respectively. Read More
Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.
National Health and Medical Research Council Centre for Research Excellence in PCOS, Monash University, Melbourne, Victoria, Australia.
Jpn J Clin Oncol 2018 Dec 6. Epub 2018 Dec 6.
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Background: We investigated the practice patterns of surgery for advanced ovarian cancer (AOC) through relevant international surveys.
Methods: After searching for 878 studies on surgery for AOC till 2017, we extracted 18 questions with similar query and answer formats from eight studies. Among them, 5 and 13 were classified as comprehensive and procedure information. Read More
Am J Epidemiol 2018 Dec 6. Epub 2018 Dec 6.
Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee.
Time between arrest of pregnancy development and miscarriage represents a window in which pregnancy is nonviable and not developing. In effect, the loss has happened and exposures cannot influence its fate. However, epidemiologic studies of miscarriage traditionally use gestational age at miscarriage to assign time in survival analyses, which overestimates duration of exposure and time at risk. Read More
Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.
Graduate School of Health Sciences, Koc University, Davutpasa, Topkapi, Istanbul, Turkey.
Study Question: Are there any differences in the molecular characteristics of the luteal granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that may help explain the defective luteal phase in the former?
Summary Answer: Luteal GC of stimulated IVF cycles, particularly those of agonist-triggered antagonist cycles, are less viable ex vivo, express LH receptor and anti-apoptotic genes at lower levels, undergo apoptosis earlier and fail to maintain their estradiol (E2) and progesterone (P4) production in comparison to natural cycle GC.
What Is Known Already: Luteal function is defective in stimulated IVF cycles, which necessitates P4 and/or hCG administration (known as luteal phase support) in order to improve clinical pregnancy rates and prevent miscarriage. The luteal phase becomes shorter and menstruation begins earlier than a natural cycle if a pregnancy cannot be achieved, indicative of early demise of corpus luteum (premature luteolysis). Read More
Curr Opin Obstet Gynecol 2018 Dec 5. Epub 2018 Dec 5.
Department of Hematology, Oncology and Tumour Immunology, Charité University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany.
Purpose Of Review: Over the last decades the time which is needed to translate a preclinical finding or idea in the clinic has reduced continuously. Especially but not only for breast cancer the number of tested drugs and targeted pathways have increased immensely. In addition, the introduction of immune-oncological treatments has further advanced the possibilities for future treatments. Read More
Curr Opin Obstet Gynecol 2018 Dec 5. Epub 2018 Dec 5.
Department of Gynecology and Obstetrics, Regio Klinikum Pinneberg, Pinneberg, Germany.
Purpose Of Review: Cyclin-dependent kinases (CDK) are key regulatory enzymes that control cell cycle and cell division. In the recent years, new therapeutic options selectively targeting CDK 4 and 6 have shown promising clinical activity in several solid tumors. Since 2015, three CDK 4/6 inhibitors have been approved for treatment of hormone receptor-positive HER2-negative metastatic breast cancer: palbociclib, ribociclib and abemaciclib. Read More
J Obstet Gynaecol Res 2018 Dec 6. Epub 2018 Dec 6.
Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.
A 41-year-old woman (gravida 2, para 1) underwent elective termination of pregnancy at approximately 7 weeks of gestation. At 1 month after the elective abortion, she was referred due to abnormal results in a cervical cytological examination. Transvaginal ultrasonography showed a heterogeneous mass of 16 mm in diameter in the left adnexal region. Read More
Transfusion 2018 Dec 6. Epub 2018 Dec 6.
Fetal Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510000, China.
Background: Alloanti-M was once regarded as not clinically significant, with a few exceptions in extremely rare cases. However, an increasing number of cases of severe hemolytic disease of the fetus and newborn (HDFN), resulting in fetal hydrops and recurrent abortion caused by alloanti-M, have been reported mainly in the Asian population.
Study Design And Methods: Three pregnant Chinese women with a history of abnormal pregnancy with hydrops fetalis were encountered. Read More
Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.
Academic Department Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.
Objective: To assess the neurodevelopmental outcome of children with spina bifida aperta (SBA) who were treated prenatally as compared to those treated postnatally.
Methods: We performed a systematic review of the literature comparing neurological outcomes of prenatally and postnatally repaired spina bifida in Pubmed/MEDLINE, Embase, Web of Science and Cochrane Library. We retrieved all randomized and non-randomized prospective controlled studies. Read More
Genes Chromosomes Cancer 2018 Dec 5. Epub 2018 Dec 5.
Institute of Pathology, Hannover Medical School, Hannover, Germany.
HER2-positive breast cancer is defined by amplification or overexpression of the HER2/ERBB2 oncogene and accounts for about 15% of breast cancer (BC) cases. Somatic mutation of ERBB2 is an alternative mechanism, by which activation of HER2 signaling can occur. ERBB2 mutation has been associated with invasive lobular breast cancer (ILBC). Read More
Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.
Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.
Background: A minimum data set, known as a core outcome set, should standardise outcome selection, collection, and reporting across future twin-to-twin transfusion syndrome research.
Methods: An international steering group including healthcare professionals, researchers, and patients, guided the development of this core outcome set. Potential core outcomes, identified through a comprehensive literature review, were entered into a three round Delphi survey. Read More
J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.
Department of Gynecology, Linyi People's Hospital, Linyi, China.
Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients who underwent IVF-ET and patients with non-PCOS-related infertility were selected in the study. Read More
Prenat Diagn 2018 Dec 5. Epub 2018 Dec 5.
Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, Rutgers/Robert Wood Johnson Medical School, New Brunswick, NJ.
Advanced paternal age (APA) is associated with infertility and other reproductive risks. Studies looking at APA and outcomes have used different paternal age cut-offs, which has complicated systematic evaluations of reproductive risk associated with paternal aging. This review of the literature suggests that the impact of paternal aging on adverse reproductive outcomes is small, but significant. Read More
J Cancer Educ 2018 Dec 5. Epub 2018 Dec 5.
University of Virginia, Charlottesville, VA, USA.
Virginia has some of the lowest HPV vaccination rates, despite being one of the few states in the USA requiring adolescent girls receive the vaccine. Provider characteristics may be an important factor in HPV vaccination. Thus, the present study assessed provider vaccination, practices, knowledge about the vaccine, and confidence in performing behaviors related to the vaccine. Read More
J Ultrasound 2018 Dec 5. Epub 2018 Dec 5.
Department of Physical Medicine and Rehabilitation, Sanggye Paik Hospital, Inje University College of Medicine, Sanggye 7 dong 761-7, Nowon-gu, 139-707, Seoul, South Korea.
Purpose: Recent studies have compared the therapeutic efficacy and safety of the procedure using ultrasound and fluoroscopy. However, there are no published studies comparing the therapeutic efficacy and safety of fluoroscopy (FL)-guided cervical interlaminar epidural steroid injection (CIESI) with that of ultrasound (US)-guided selective nerve root block (SNRB). This study aimed to compare the mid-term effects and advantages of US-guided SNRB with FL-guided CIESI for radicular pain in the lower cervical spine through assessment of pain relief and functional improvement. Read More
Immunol Res 2018 Dec 6. Epub 2018 Dec 6.
Department of Obstetrics and Gynecology, National Research Center of Mother and Child Health, University Medical Center, 32 Turan Avenue, Astana, 010000, Kazakhstan.
The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study. The study was conducted in Sary-Agach District (OCPs exposed girls) and Sairam District (OCPs unexposed controls), South Kazakhstan. The study included 524 female adolescents aged 10-17 years (OCPs exposed, n = 253; OCPs unexposed, n = 271). Read More
Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No 1, Dongcheng District, Beijing, China.
Objective: To investigate the incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection (EFC).
Methods: All patients with EFC diagnosed by transvaginal sonography (TVS) were retrospectively reviewed if they had undergone biopsy of the endometrium from January 2008 to January 2016 in a tertiary teaching hospital. Follow-up ended in June 2017. Read More
Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.
Department of Obstetrics, University of Leipzig, Liebigstrasse 20a, 04103, Leipzig, Germany.
Purpose: Uterine rupture during labor is a rare but life-threatening complication after previous cesarean section (CS). Prenatal risk is assessed using ultrasound thickness measurement of the lower uterine segment (LUS). Due to inhomogeneous study results, however, clinical obstetrics still lacks for standard protocols and reliable reference values. Read More
Reprod Biomed Soc Online 2018 Aug 7;6:72-79. Epub 2018 Nov 7.
Yale University, Fertility Center, New Haven, CT, USA.
This study examined the attitudes of obstetrics and gynaecology (OB/GYN) resident physicians to initiating patient discussions regarding medical and elective oocyte cryopreservation (OC). The study used a cross-sectional online survey of OB/GYN medical residents in the USA, sampled from residency programmes approved by the American Council for Graduate Medical Education. In total, 208 medical residents, distributed evenly between postgraduate years 1-4, participated in the study. Read More
Biochem Biophys Rep 2019 Mar 20;17:17-22. Epub 2018 Nov 20.
Department of Gynaecology and Obstetrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong, China.
Single-nucleotide polymorphisms (SNPs) located in the promoter region of the receptor for advanced glycation end products () gene have been linked to the activity of RAGE. However, contrary to our expectation, we previously detected no correlation between SNPs within the RAGE promoter and ulcerative colitis (UC) risk in a case-control study. Here, we investigated the methylation of the promoter and analyzed the collective contribution of methylation and SNPs to UC risk. Read More
Gynecol Oncol Rep 2019 Feb 20;27:6-7. Epub 2018 Nov 20.
Division of Gynecologic Oncology, Arizona Oncology (US Oncology Network), University of Arizona College of Medicine, Creighton University School of Medicine at St. Joseph's Hospital Phoenix, AZ, United States.
Gynecol Oncol Rep 2019 Feb 12;27. Epub 2018 Nov 12.
Multidisciplinary Breast Clinic, Unit Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Antwerp University Hospital and the Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Front Pediatr 2018 16;6:323. Epub 2018 Nov 16.
Neonatal and Intensive Care Department, University Hospital, Medical University of Warsaw, Warsaw, Poland.
High-pressure processing (HPP) is a non-thermal technology that is being increasingly applied in food industries worldwide. It was proposed that this method could be used as an alternative to holder pasteurization (HoP; 62.5°C, 30 min) in milk banks but its impact on the immunologic, enzymatic and hormonal components of human milk has not yet been evaluated in detail. Read More
Front Oncol 2018 21;8:535. Epub 2018 Nov 21.
Department of Obstetrics and Gynaecology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.
The purpose of this investigation was to explore patient perception regarding the importance of efficacy, toxicity, and logistics in the choice of regimen of taxane-based chemotherapy (CHT) for patients with metastatic breast cancer (MBC). This dual-center study analyzed data of 100 women diagnosed with MBC, who were asked for their preferences regarding chemotherapy by means of conjoint analysis. Included attributes were progression free survival (PFS), application form, time and frequency, need of premedication, risk of alopecia, fatigue, febrile neutropenia, and neuropathy. Read More
Integr Med Res 2018 Dec 26;7(4):307-315. Epub 2018 Oct 26.
Department of Amraze Niswan wa Ilmul Qabalat (Gynecology and Obstetrics), National Institute of Unani Medicine, Bengaluru, India.
Background: It is not only to evaluate the efficacy and safety of mace (Arils of Houtt) but also to compare pelvic floor muscle training vs. pelvic floor muscle training (PFMT) for improving symptoms and health-related quality of life (HRQoL) of woman with mixed urinary incontinence (MUI).
Methods: A prospective, single-blind randomized controlled study was conducted. Read More
J Cancer 2018 11;9(23):4547-4555. Epub 2018 Nov 11.
Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Histone deacetylases modulate the dynamic balance of histone acetylation and deacetylation in cells, which participate in epigenetic regulations. Accumulated evidence has demonstrated that histone deacetylases are associated with angiogenesis, cell proliferation and survival in a variety of human cancers. However, the expression and distinct prognostic value of histone deacetylases in ovarian cancer have not been well elucidated. Read More
J Cancer 2018 22;9(23):4413-4421. Epub 2018 Oct 22.
Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland.
Low effectiveness of chemotherapy in ovarian cancer results from development of drug resistance during treatment. Topotecan (TOP) is a chemotherapeutic drug used in second-line chemotherapy of this cancer. Unfortunately, during treatment cancer can develop diverse cellular and tissue specific mechanisms of resistance to cytotoxic drugs. Read More
J Cancer 2018 21;9(23):4334-4340. Epub 2018 Oct 21.
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Evidence for an association between ABO blood type and epithelial ovarian cancer (EOC) survival has so far been limited and conflictive. This study applied a retrospective cohort and included 627 EOC patients diagnosed at Shengjing Hospital of China Medical University between 2011 and 2015. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) between the ABO blood type and progression-free survival (PFS) and overall survival (OS) of EOC patients were assessed using multivariable Cox proportional regression models. Read More
J Cancer 2018 20;9(22):4263-4270. Epub 2018 Oct 20.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P.R. China.
The transcriptional coactivator with the PDZ-binding motif (TAZ) has been associated with different types of cancer. In this study, we examined the TAZ protein expression and cellular localization in 194 cases of human cervical squamous cell carcinoma (SCC). We observed that a normal cervix is characterized by higher expression levels of both nuclear and cytosolic TAZ compared to cervical SCC. Read More