292,333 results match your criteria Obstetrics Gynaecology & Reproductive Medicine [Journal]


A Novel Variant of the FZD4 Gene in a Chinese Family Causes Autosomal Dominant Familial Exudative Vitreoretinopathy.

Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,

Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.

Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More

View Article
December 2018
1 Read

Case report of the successful use of Mirena levonorgestrel intrauterine system in a patient with didelphys uterus and obstructed hemivagina.

Authors:
King Cp Kives S

J Pediatr Adolesc Gynecol 2018 Dec 8. Epub 2018 Dec 8.

Section of Paediatric Gynaecology, Division of Endocrinology, Hospital for Sick Children, and the Department of Obstetrics and Gynecology, University of Toronto, 7435A-555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.

Background: The Mirena levonorgestrel intrauterine system (IUS) is frequently used for menstrual suppression in adolescents with special needs. However, the presence of a uterine anomaly is generally considered a contraindication to IUS insertion, thereby excluding a potentially highly effective option for this patient population.

Case: A Mirena IUS was utilized in a medically and surgically complex special needs 14-year-old adolescent with a didelphys uterus and obstructed hemivagina. Read More

View Article
December 2018
1 Read

MiR-34c/SOX9 axis regulates the chemoresistance of ovarian cancer cell to cisplatin-based chemotherapy.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Gynecology and Obstetrics, The Third Xiangya Hospital, Central South University, Changsha, China.

Cisplatin (DDP)-based chemotherapy is a standard strategy for ovarian cancer (OC), while chemoresistance remains a major therapeutic challenge. Transcription factor SOX9 has been reported to be associated with tumor cell proliferation, metastasis, and chemoresistance. In the current study, we observed a higher SOX9 expression in OC cell lines; SOX9 overexpression might aggravate the chemoresistance of the OC cell to DDP, whereas its knockdown enhanced the chemoresistance. Read More

View Article
December 2018

Review shows that thyroid hormone substitution could benefit transient hypothyroxinaemia of prematurity but treatment strategies need to be clarified.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Neonatology, University Hospitals Leuven, KU, Leuven, Belgium.

Aim: Thyroid hormones are crucial for fetal and neonatal brain development. This paper provides an overview of the normal role of thyroid hormones in fetal brain development and the pathophysiology of transient hypothyroxinaemia of prematurity (THOP). It also discusses the diagnostic and therapeutic controversies around THOP and looks at directions for future research. Read More

View Article
December 2018

A meta-analysis of neurodevelopmental outcomes at 4-10 years in children born at 22-25 weeks gestation.

Acta Paediatr 2018 Dec 10. Epub 2018 Dec 10.

University of Ottawa, Faculty of Medicine, Ottawa, Canada.

Aim: To update our meta-analysis on neurodevelopmental disability rates in children born at 22-25 weeks gestation. The main outcome measure was rates of neurodevelopmental disability in survivors at age 4-10 years.

Methods: We used a peer-reviewed electronic and grey search to identify articles. Read More

View Article
December 2018

High expression of LASS2 is associated with unfavorable prognosis in patients with ovarian cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.

Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2), is a gene isolated from a human liver complementary DNA library. In this study, we found that LASS2 protein level was positively related to International Federation of Gynecology and Obstetrics (FIGO) stage and LASS2-negative tumors showed significant association with longer disease-free survival (DFS) and overall survival (OS) in ovarian cancer patients. The heterogeneous expression of LASS2 had been exhibited in diverse ovarian cancer cells. Read More

View Article
December 2018

Incidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital.

J Obstet Gynaecol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aim: To obtain the incidence of preterm premature rupture of membranes (PPROM) at Siriraj Hospital during 2012-2016 and to identify its possible risk factors in singleton pregnancies.

Methods: This study was a retrospective case-control study. The institutional ethical committee has approved the study. Read More

View Article
December 2018

Prenatal diagnosis of antenatal midgut volvulus: Specific ultrasound features.

Prenat Diagn 2018 Dec 9. Epub 2018 Dec 9.

Department of Pediatric Imaging, CHU Montpellier, Montpellier, France.

Objective: To assess specific, direct, and indirect prenatal ultrasound features in cases of fetal midgut volvulus.

Methods: Retrospective case series of neonatal volvulus, based on postnatal and prenatal imaging findings that occurred from 2006-2017. Prenatal and postnatal signs including the specific "whirlpool sign" were computed. Read More

View Article
December 2018

Is the positive predictive value of high-grade cytology in predicting high-grade cervical disease falling due to HPV vaccination?

Int J Cancer 2018 Dec 10. Epub 2018 Dec 10.

VCS Population Health, VCS Foundation, Level 6, 176 Wellington Parade, East Melbourne, VIC, 3002, Australia.

A fall in the positive predictive value (PPV) of cytological predictions of high-grade squamous intraepithelial lesions (HSIL) or adenocarcinoma-in-situ (AIS) has been predicted in the post HPV vaccination era due to the decrease in underlying prevalence of cervical lesions. Data was extracted from the Victorian Cervical Screening Registry including cervical cytology tests taken between 2000 and 2016 and any subsequent histology performed within six months of the cytology. PPV was calculated for each age group (<20, 20-24, 25-29, 30-34, 35-39, 40-49, 50-59, 60-69, 70+ years) and calendar year. Read More

View Article
December 2018

Transvaginal ultrasound training for the obstetrics and gynecology resident: A multisite randomized controlled trial of educational DVD.

J Clin Ultrasound 2018 Dec 7. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, The Reading Hospital, Reading, Pennsylvania.

Purpose: Residents in obstetrics and gynecology are deemed to be proficient in transvaginal ultrasound (TVUS) upon graduation, although TVUS education in residency is not standardized. The objective of this study is to assess for improvement in TVUS knowledge among residents after viewing an educational DVD.

Methods: This is a multisite prospective randomized controlled trial using an educational DVD ("Gynecology: Beginners Only"), compared to routine education. Read More

View Article
December 2018

Activation of TGF-β1/Smad3 signaling pathway inhibits the development of ovarian follicle in polycystic ovary syndrome by promoting apoptosis of granulosa cells.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.

Objective: To investigate the role of the transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathway in development of ovarian follicle by promoting apoptosis of granulosa cells in polycystic ovary syndrome (PCOS).

Methods: A total of 54 female rats were obtained and randomly assigned into the PCOS (n = 27) and control groups ( n = 27). PCOS rat models were constructed using the dehydroepi-androsterone method to observe ovarian morphology and ultrastructure. Read More

View Article
December 2018

Quantitative Proteomics by SWATH-MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus.

Proteomics 2018 Dec 7:e1800164. Epub 2018 Dec 7.

Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, QLD, 4029, Australia.

Several factors including placental hormones (PH) released from the human placenta have been associated with the development of insulin resistance and gestational diabetes mellitus (GDM). However, circulating levels of PH do not correlate well with maternal insulin sensitivity across gestation, suggesting that other, previously unrecognized, mechanisms may be involved. The levels of circulating exosomes are higher in GDM compared to normal. Read More

View Article
December 2018
3.807 Impact Factor

Silencing H19 regulated proliferation, invasion, and autophagy in the placenta by targeting miR-18a-5p.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. It may lead to neurodevelopmental impairment and adulthood onset disorders. Recently, long noncoding RNAs (lncRNAs) were found to be associated with the pathogenesis of FGR. Read More

View Article
December 2018

A Narrow Escape From Methotrexate: The Importance of Correlating Ultrasound Findings With Discriminatory Level of β-hCG and the β-hCG Ratio.

J Ultrasound Med 2018 Dec 11. Epub 2018 Dec 11.

Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia.

View Article
December 2018

microRNA-96 protects pancreatic β-cell function by targeting PAK1 in gestational diabetes mellitus.

Biofactors 2018 Nov 8;44(6):539-547. Epub 2018 Dec 8.

Department of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Gestational diabetes mellitus (GDM) is a disease condition in which a woman develops high blood sugar levels during pregnancy, which might be induced by multiple factors. Among those relative factors, microRNA (miRNA) is well-known to be involved in GDM development. In this study, we investigated the role of miRNA in GDM by analyzing miRNA expression profiling in placenta tissues from healthy or GDM pregnancies. Read More

View Article
November 2018

Fetal myelomeningocele surgery: Only treating the tip of the iceberg.

Prenat Diagn 2018 Dec 10. Epub 2018 Dec 10.

Fetal Medicine Unit, Department of Obstetrics & Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada.

Objective: Fetal myelomeningocele (fMMC) surgery improves infant outcomes when compared with postnatal surgery. Surgical selection criteria and the option of pregnancy termination, however, limit the number of cases that are eligible for prenatal surgery. We aimed to quantify what proportion of cases could ultimately benefit from fetal therapy. Read More

View Article
December 2018

Aicardi syndrome, an unsolved mystery: Review of diagnostic features, previous attempts, and future opportunities for genetic examination.

Am J Med Genet C Semin Med Genet 2018 Dec 10. Epub 2018 Dec 10.

Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

Aicardi syndrome is a rare, severe neurodevelopmental disorder classically characterized by the triad of infantile spasms, central chorioretinal lacunae, and agenesis of the corpus callosum. Aicardi syndrome only affects females, with the exception of a few males with a 47, XXY chromosome constitution. All cases are de novo and the only cases of definitive recurrence in families are in identical twins. Read More

View Article
December 2018
1 Read

Ethanol Normalizes Glutamate-Induced Elevation of Intracellular Sodium in Olfactory Neuroepithelial Progenitors from Subjects with Bipolar Illness but not Non-Bipolar Controls: Biologic Evidence for the Self-Medication Hypothesis.

Bipolar Disord 2018 Dec 9. Epub 2018 Dec 9.

Mood Disorders Research Program, Department of Psychiatry and Behavioral Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.

Alcohol use disorders are quite common in bipolar patients with a prevalence of comorbidity that exceeds all other primary psychiatric diagnoses other than other substance use disorders; over 60% of people with BD I have comorbid alcohol dependence at some point in their lives. This intimate relationship has served as the basis of the proposed idea of 'self-medication.' However, biological confirmation of 'self-medication,' specifically, the correction of an abnormal biologic marker with alcohol, has never been demonstrated. Read More

View Article
December 2018

Response to Invited Editorial: Intravenous iron use in pregnancy: Ironing out the issues and evidence.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E28-E29

Department of Obstetrics and Maternal/Fetal Medicine, Canberra Hospital and Health Service, Canberra, Australian Capital Territory, Australia.

View Article
December 2018

Management of iron-deficiency anaemia in pregnancy: a tale of surrogates and supposition.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E32-E33

Department of Obstetrics and Gynaecology, Flinders Medical Centre, Adelaide, South Australia, Australia.

View Article
December 2018

We need to treat pregnant women as adults: Women should be consented for an attempt at normal vaginal birth as for operative delivery, with risks and potential complications explained.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):701-703

Sydney Law School, University of Sydney, Sydney, New South Wales, Australia.

Since the mid-90s, Australian law has required doctors to disclose material risks of proposed treatment. Medical practitioners have had two decades to adapt, and, by and large, patient autonomy is acknowledged and respected by obtaining 'informed consent'. While problems with obtaining consent do surface in medico-legal litigation, practitioners are generally aware of the need to do so and usually comply with requirements. Read More

View Article
December 2018

Iron in pregnancy.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E29-E30

Australian National University Medical School, Canberra, Australian Capital Territory, Australia.

View Article
December 2018

Reply to: Response to placental growth factor as an indicator of fetal growth restriction in late-onset small-for-gestational age pregnancies.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E24

Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand.

View Article
December 2018

Vaginal examination and fear of childbirth.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E24-E25

Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan.

View Article
December 2018

Authors' reply to letters commenting on the editorial entitled Intravenous iron use in pregnancy: Ironing out the issues and evidence.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E31-E32

Clinical and Population Perinatal Health Research, Kolling Institute, St Leonards, New South Wales, Australia.

View Article
December 2018

An In-depth Perspective of Aortic Arch Branching in Fetal Vascular Rings Using Spatiotemporal Image Correlation Combined With High-definition Flow Imaging: Report of 4 Cases.

J Ultrasound Med 2018 Dec 11. Epub 2018 Dec 11.

Pediatric Cardiology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.

On the basis of 2-dimensional fetal echocardiographic findings, we investigated 4 different fetal vascular ring cases using spatiotemporal image correlation (STIC) combined with high-definition (HD) flow imaging. An in-depth 3-dimensional perspective of aortic arch branching (ie, the brachiocephalic arteries) was created by application of glass body and HDlive flow rendering algorithms (GE Healthcare, Zipf, Austria). Additionally, complete (U- or O-shaped) or incomplete (C-shaped) vascular rings were clearly differentiated in utero, and articulations around the trachea and esophagus were more easily imaged. Read More

View Article
December 2018

Brain structure and neurological and behavioural functioning in infants born preterm.

Dev Med Child Neurol 2018 Dec 10. Epub 2018 Dec 10.

Murdoch Children's Research Institute, Melbourne, Vic., Australia.

Aim: To examine: (1) relationships between brain structure, and concurrently assessed neurological and behavioural functioning, in infants born preterm at term-equivalent age (TEA; approximately 38-44wks); and (2) whether brain structure-function relationships differ between infants born very (24-29wks) and moderate-late (32-36wks) preterm.

Method: A total of 257 infants (91 very preterm, 166 moderate-late preterm; 120 males, 137 females) had structural magnetic resonance imaging (MRI) and neurological and behavioural assessments (Prechtl's general movements assessment, Neonatal Intensive Care Unit Network Neurobehavioral Scale [NNNS] and Hammersmith Neonatal Neurological Examination [HNNE]). Two hundred and sixty-three infants (90 very preterm, 173 moderate-late preterm; 131 males, 132 females) had diffusion MRI and assessments. Read More

View Article
December 2018
1 Read

Impacts of Cytochrome P450 2D6 (CYP2D6) Genetic Polymorphism in Tamoxifen Therapy for Breast Cancer.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):794-799. Epub 2018 Dec 7.

School of Medicine, Department of Health Sciences, Faculdade Mauricio de Nassau, Cabo de Santo Agostinho, Recife, PE, Brazil.

Tamoxifen (TMX) is the main drug used both in pre and postmenopausal women as adjuvant treatment for hormone receptor-positive breast cancer. An important barrier to the use of TMX is the development of drug resistance caused by molecular processes related to genetic and epigenetic mechanisms, such as the actions of cytochrome P450 2D6 () polymorphisms and of its metabolites. The present study aimed to review recent findings related to the impact of polymorphisms and how they can affect the results of TMX in breast cancer treatment. Read More

View Article
December 2018

Association between Caffeine Consumption in Pregnancy and Low Birth Weight and Preterm Birth in the birth Cohort of Ribeirão Preto.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):749-756. Epub 2018 Dec 7.

Department of Pediatrics, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Objective:  To describe caffeine consumption during pregnancy and its association with low birth weight (LBW) and preterm birth in the birth cohort of Ribeirão Preto, state of São Paulo, Brazil, in 2010.

Methods:  Cohort study, with descriptive and analytical approach. Data included 7,607 women and their newborns in Ribeirão Preto, state of São Paulo, Brazil. Read More

View Article
December 2018
1 Read

The Role of Caspase-3, Apoptosis-Inducing Factor, and B-cell Lymphoma-2 Expressions in Term Premature Rupture of Membrane.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):733-739. Epub 2018 Dec 7.

Department of Public Health, Dhyana Pura University, Bali, Indonesia.

Objective:  To determine the role of caspase-3, apoptosis-inducing factor (AIF), and B-cell lymphoma-2 (Bcl-2) expressions in term premature rupture of membrane (PROM).

Methods:  An analytic observational study with case-control design was conducted, involving 52 subjects (37-42 weeks of gestation) who were divided into 2 groups: 26 cases of term delivery with PROM, and 26 controls of term delivery without PROM. The expressions of caspase-3, AIF, and Bcl-2 in the amniotic membrane were determined by immunohistochemistry. Read More

View Article
December 2018

Prenatal Diagnosis and Intrapartum Management of Congenital Ranula.

Z Geburtshilfe Neonatol 2018 Dec 10;222(6):262-265. Epub 2018 Dec 10.

Obstetrics and Gynecology, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya, Turkey.

A foetal sublingual cystic lesion was diagnosed by routine prenatal ultrasonography at 27 weeks of gestation. Foetal growth and amniotic fluid volume were normal. An ex utero intrapartum treatment (EXIT) procedure was performed, and the cyst was aspirated to allow breathing during planned Caesarean section. Read More

View Article
December 2018
1 Read

Transcervical Foley balloon catheter and vaginal prostaglandin E2 insert combination vs. vaginal prostaglandin E2 insert only for induction of labor at term: a randomized clinical trial.

Arch Gynecol Obstet 2018 Dec 7. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children's Health Training and Research Hospital, Istanbul, Turkey.

Purpose: To analyze the effect of combined application of intravaginal PGE2 insert and intracervical Foley balloon catheter for induction of labor.

Methods: Patients with unfavorable cervices who required induction of labor from August 2017 to December 2017 were evaluated for the study. Three hundred and ten participants were randomly assigned to study (n:155) and control group (n:155). Read More

View Article
December 2018

Assessment of heavy metals (total chromium, lead, and manganese) contamination of residential soil and homegrown vegetables near a former chemical manufacturing facility in Tarnaveni, Romania.

Environ Monit Assess 2018 Dec 8;191(1). Epub 2018 Dec 8.

Department of Health, Environmental Health Center, 58 Busuiocului Street, 400240, Cluj-Napoca, Romania.

Our aim was to assess local population exposure to heavy metals resulting from soil and vegetable contamination in Tarnaveni, Romania, an area located near a former chemical factory. We collected residential soil and vegetable samples from Tarnaveni and measured chromium (Cr), lead (Pb), and manganese (Mn) levels by atomic absorption spectrometry. We evaluated the relationship between soil and vegetable metals and the distance from the shuttered chemical factory, and calculated the hazard index to assess local population metal exposure via contaminated vegetable ingestion. Read More

View Article
December 2018

Biodistribution and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles In Vitro and In Vivo.

Curr Med Sci 2018 Dec 7;38(6):1096-1102. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.

Biodistribution and toxicity assessment are critical for safe clinical use of newly developed medicines. Superparamagnetic iron oxide nanoparticles (SPION) are effective carriers for targeted drug delivery. This study aimed to examine the toxicity and biodistribution of SPION coated with polyethylenimine (PEI) (SPION-PEI) designed for small interfering RNA (siRNA) delivery both in vitro and in vivo. Read More

View Article
December 2018

Risk Factors for Strangulated Ovarian Hernia in Female Infants: the Role of Ovarian Volume.

Curr Med Sci 2018 Dec 7;38(6):1032-1037. Epub 2018 Dec 7.

Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

The risk factors associated with strangulated ovarian hernia (SOH) in female patients (<1 year old) were identified. A retrospective analysis was conducted regarding the data from 2006 to 2017. The patients were divided into 2 groups: SOH group (n=9) and non-SOH group (n=23). Read More

View Article
December 2018
1 Read

Relationship between Volatile Anesthetics and Tumor Progression: Unveiling the Mystery.

Curr Med Sci 2018 Dec 7;38(6):962-967. Epub 2018 Dec 7.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

A series of factors can be involved in the perioperative period to cause an increase in cancer-related mortality. Unfortunately, volatile anesthesia might aggravate the deleterious effects. In this article, we review the association of diverse volatile anesthetic agents with immune system and cancer cell biology, and examine the effects on angeogenesis and postoperative metastasis or recurrence. Read More

View Article
December 2018

Reviews based on the 17th "Endorama Meeting".

Hormones (Athens) 2018 Dec 7. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Patras Medical School, Patras, Greece.

View Article
December 2018

Left atrial strain improves estimation of filling pressures in heart failure: a simultaneous echocardiographic and invasive haemodynamic study.

Clin Res Cardiol 2018 Dec 10. Epub 2018 Dec 10.

Institution for Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

Aims: Left ventricular diastolic pressure estimation is essential for characterization of heart failure (HF). Patients with normal resting left atrial (LA) pressures (LAP), but steep LAP elevation on exertion, pose a particular diagnostic challenge. Current recommendations on echocardiographic LAP estimation have limited accuracy. Read More

View Article
December 2018

Outcome of pregnancy in women with psoriatic arthritis compared to healthy controls.

Clin Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Centre for Prognosis Studies in the Rheumatic Diseases, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Objectives: The mean age at onset of psoriatic arthritis (PsA) ranges between the 4th-6th decades of life. However, little is known about fertility and pregnancy outcome in PsA patients. The aim of this study was to examine whether fertility and pregnancy outcome of PsA patients are different from healthy controls and to evaluate PsA and psoriasis disease activity perception during pregnancy and the year postpartum. Read More

View Article
December 2018

Anovaginal distance and obstetric anal sphincter injury: a prospective observational study.

Int Urogynecol J 2018 Dec 10. Epub 2018 Dec 10.

Department of Obstetrics and Gynecology, and Department of Clinical and Experimental Medicine, Linköping University, SE-581 85, Linköping, Sweden.

Introduction And Hypothesis: No measurements are available for diagnosing the extent of obstetric lacerations. The primary aim of this study was to evaluate the relation between the anovaginal distance (AVD) measured with transperineal ultrasound immediately after delivery and external anal sphincter injury. A secondary aim was to assess whether the palpated perineal thickness was associated with the AVD. Read More

View Article
December 2018
1 Read

The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study.

Int Urogynecol J 2018 Dec 10. Epub 2018 Dec 10.

Department of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Introduction And Hypothesis: Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with postmenopausal women without POP. Furthermore, we identified clinical risk factors associated with POP in our study population. Read More

View Article
December 2018

Factors associated with post-relapse survival in patients with recurrent cervical cancer: the value of the inflammation-based Glasgow Prognostic Score.

Arch Gynecol Obstet 2018 Dec 10. Epub 2018 Dec 10.

Gynecologic Cancer Unit, Department of Gynecology and Gynecologic Oncology, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.

Purpose: The aim of the present study was to assess the value of the Glasgow Prognostic Score (GPS) as a prognostic tool for predicting post-relapse survival (PRS) in patients with recurrent cervical cancer.

Methods: We retrospectively evaluated the data of 116 patients with recurrent cervical cancer in whom serologic biomarkers had been assessed at the time of relapse. The GPS was calculated as follows: patients with elevated serum C-reactive protein levels and hypoalbuminemia were allocated a score of 2, and those with 1 or no abnormal value were allocated a score of 1 and 0, respectively. Read More

View Article
December 2018

Assaying Reproductive Capacity in Female Rodents.

Methods Mol Biol 2019 ;1916:157-166

MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

It is an important part of many rodent studies to assess reproductive capacity in the female. Animal models that involve exposure to organic compounds, teratogenicity studies, or exposure to suboptimal environments during early development often result in deficits in female fertility. In addition to longitudinal physiology assays of fecundity, there are several molecular biology approaches to assessing female reproductive potential that can be performed to provide a "snapshot" of fertility potential at a single time-point. Read More

View Article
January 2019

Impact of individualized target mean arterial pressure for septic shock resuscitation on the incidence of acute kidney injury: a retrospective cohort study.

Ann Intensive Care 2018 Dec 10;8(1):124. Epub 2018 Dec 10.

Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background: To examine the relationship between delta mean arterial pressure (ΔMAP; MAP change between pre-admission minus post-resuscitation) and acute kidney injury (AKI) among patients with septic shock. In this retrospective, single-center cohort study of adult patients pre-admission MAP is defined as the median MAP recorded from 365 to 7 days before admission. Post-resuscitation MAP was median MAP during the 7th hour after initiating resuscitation. Read More

View Article
December 2018
1 Read

Correlation of human telomerase reverse transcriptase single nucleotide polymorphisms with in vitro fertilisation outcomes.

J Assist Reprod Genet 2018 Dec 10. Epub 2018 Dec 10.

Reproductive Medicine Center, Department of Obstetrics and Gynaecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No.107, Yanjiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China.

Purpose: To explore whether it is possible to predict the number and quality of the embryo using a few particular hTERT SNPs.

Methods: We included 997 Han Chinese women who were genetically unrelated and underwent assisted reproduction using IVF from September 2014 to December 2015. DNA was genotyped by using TaqMan real-time quantitative PCR. Read More

View Article
December 2018

Neuroendocrine characteristics of induced pluripotent stem cells from polycystic ovary syndrome women.

Protein Cell 2018 Dec 10. Epub 2018 Dec 10.

Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.

View Article
December 2018

A window-of-opportunity clinical trial of dasatinib in women with newly diagnosed endometrial cancer.

Cancer Chemother Pharmacol 2018 Dec 8. Epub 2018 Dec 8.

Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.

Objective: To determine the extent of dasatinib uptake and effect on Src kinase activity in tumor, normal adjacent tissue, and blood in newly diagnosed endometrial cancer patients.

Methods: Dasatinib was dosed at 100 or 200 mg PO BID at 32 and 8 h preoperatively. Blood and tissue were collected pre-treatment and at surgery to assess active (pY419) and total Src protein (pharmacodynamics [PD]) and pharmacokinetics (PK). Read More

View Article
December 2018

The Effects of Probiotic Supplementation on Genetic and Metabolic Profiles in Patients with Gestational Diabetes Mellitus: a Randomized, Double-Blind, Placebo-Controlled Trial.

Probiotics Antimicrob Proteins 2018 Dec 8. Epub 2018 Dec 8.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran.

This study was carried out to evaluate the effects of probiotic supplementation on genetic and metabolic profiles in patients with gestational diabetes mellitus (GDM) who were not on oral hypoglycemic agents. This randomized, double-blind, placebo-controlled clinical trial was conducted in 48 patients with GDM. Participants were randomly divided into two groups to intake either probiotic capsule containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum, Lactobacillus fermentum (2 × 10 CFU/g each) (n = 24) or placebo (n = 24) for 6 weeks. Read More

View Article
December 2018

Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes.

Int J Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, P.R. China.

The present study investigated the mechanisms of apoptosis induced by cryptotanshinone (CT) in human rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLSs). Cell Counting kit‑8 assay was performed to determine the cytotoxic effects of CT in human RA‑FLSs, including primary RA‑FLS, HFLS‑RA and MH7A cells, and in HFLS cells derived from normal synovial tissue. Annexin V‑FITC/PI staining was used to detect the apoptotic effects of CT in HFLS‑RA and MH7A cells. Read More

View Article
December 2018

YWHAZ promotes ovarian cancer metastasis by modulating glycolysis.

Oncol Rep 2018 Dec 7. Epub 2018 Dec 7.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, P.R. China.

Ovarian cancer is one of the three most deadly gynecological cancers, with the highest mortality rate. As the main cause of death, metastasis is considered to be a crucial factor that reduces the survival time of ovarian carcinoma patients. YWHAZ (also known as 14‑3‑3ζ) influences diverse vital cellular processes such as metabolism, signal transduction, apoptosis and cell cycle regulation. Read More

View Article
December 2018