63,571 results match your criteria Obstetrics Gynaecology & Reproductive Medicine [Journal]


Tissue engineering approaches for treating pelvic organ prolapse using a novel source of stem/stromal cells and new materials.

Curr Opin Urol 2019 Apr 16. Epub 2019 Apr 16.

The Ritchie Centre and Centre for Reproductive Health, Hudson institute of Medical Research.

Purpose Of Review: Nondegradable transvaginal polypropylene meshes for treating pelvic organ prolapse (POP) are now generally unavailable or banned. In this review, we summarize recent developments using tissue engineering approaches combining alternate degradable scaffolds with a novel source of mesenchymal stem/stromal cells from human endometrium mesenchymal stem cell (eMSC).

Recent Findings: Tissue engineering constructs comprising immunomodulatory, reparative eMSC and biomimetic materials with nanoarchitecture are a promising approach for vaginal repair and improving outcomes of POP surgery. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000634DOI Listing

Symposium on "parental education" at the ICCH17.

Int J Circumpolar Health 2019 Dec;78(1):1604062

a Centre for Public Health in Greenland, National Institute of Public Health , University of Southern Denmark , Copenhagen , Denmark.

This symposium report provides a brief overview of the six programmes and studies on parental education and maternal health services within the circumpolar region presented in the symposium "parental education" at the 17th International Congress of Circumpolar Health in Copenhagen, Denmark, August 2018. Read More

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http://dx.doi.org/10.1080/22423982.2019.1604062DOI Listing
December 2019

Patient costs and outcomes before and after the institution of a pre-eclampsia quality improvement initiative in a southwestern tertiary facility.

J Obstet Gynaecol 2019 Apr 22:1-5. Epub 2019 Apr 22.

e Marian Regional Medical Centre , Maternal-Foetal Medicine , Santa Maria , CA , USA.

The study objective was to evaluate the effect of the California Maternal Quality Care Collaborative (CMQCC) initiative, as implemented in a southwestern U.S. tertiary hospital, on associated patient costs and outcomes. Read More

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http://dx.doi.org/10.1080/01443615.2019.1575343DOI Listing

[Slit/Robo pathway participates in luteal cells apoptosis].

Sheng Li Xue Bao 2019 Apr;71(2):287-293

Department of Scientific Research Center, Shijiazhuang First Hospital, Shijiazhuang 050011, China.

This study was aimed to examine the expression and function of Slit/Robo family members in mouse ovary. Real-time PCR was used to assess the mRNA expression levels of Slit/Robo family members, and immunohistochemistry was used to examine the location of Slit2 and Robo1 in the ovary. The mRNA and protein expression levels of Slit2 and Robo1 in early-, middle- and late-phase corpus luteum (CL) were examined by real-time PCR and immunohistochemistry, respectively. Read More

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Maternal heart rate patterns under resting conditions in late pregnancy.

Trends Res 2018 Sep 12;1(3). Epub 2018 Sep 12.

Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.

Objectives: To describe maternal heart rate patterns observed during antenatal monitoring under resting conditions between the gestational ages of 34 to 38 weeks and to demonstrate its associations with uterine activity.

Methods: Each participant had five high quality ECG electrodes attached to her anterior abdominal wall which were connected to the Monica AN24 device to collect raw electrical signals from the maternal and fetal ECG and signals of uterine activity. Proprietary software was then used to download the raw data and extract the maternal and fetal heart rate patterns and uterine activity. Read More

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http://dx.doi.org/10.15761/TR.1000116DOI Listing
September 2018

The assessment of the quality of randomized controlled trials published in Indian medical journals.

Perspect Clin Res 2019 Apr-Jun;10(2):79-83

Department of Clinical Pharmacology, SRM MCH and RC, Kattankulathur, Kancheepuram, Chennai, Tamil Nadu, India.

Aim: In this retrospective cross-sectional study, we sought to evaluate if the published randomized controlled trials (RCTs) reported in the year 2017 among the Indian medical journals (IMJs) complied with the Consolidated Standards of Reporting Trials (CONSORT) guidelines and identify domains where reporting could be improved.

Methods: A literature search was performed using PubMed and Google Scholar to identify all the IMJs that published RCTs in the year 2017. In the archives of the identified journals, the number of published RCTs was identified and the full text was obtained. Read More

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http://dx.doi.org/10.4103/picr.PICR_60_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463507PMC

A cross-sectional study of traditional practices affecting maternal and newborn health in rural Nigeria.

Pan Afr Med J 2018 28;31:64. Epub 2018 Sep 28.

Department of Obstetrics and Gynaecology, Ahmadu Bello University, Zaria, Nigeria.

Introduction: Certain traditional practices which have negative effects on maternal and child health continue to be practiced in sub-Saharan African countries. A survey was carried out in a rural village in Nigeria to understand the scale and range of these practices.

Methods: This was a cross-sectional study in which trained interviewers administered pre-tested questionnaires on child-bearing women using questionnaires embedded on android devices. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.64.15880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457866PMC
September 2018

The inhibition of miR-126 in cell migration and invasion of cervical cancer through regulating ZEB1.

Hereditas 2019 9;156:11. Epub 2019 Apr 9.

1Department of Gynaecology and Obstetrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing Medical University, No. 321 Zhongshan Road, Gulou District, Nanjing, 210008 Jiangsu China.

Background: Cervical cancer is a malignancy that's common in female with high incidence and mortality worldwide. MicroRNAs (miRNAs) act a pivotal part in human cancer development. Our aim was to investigate the effect of miR-126 on cervical cancer and its underlying molecular mechanism. Read More

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https://hereditasjournal.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s41065-019-0087-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456986PMC
April 2019
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A Multicenter, Randomized, Equivalence Trial of a New Recombinant Human Chorionic Gonadotropin Preparation versus Ovitrelle for Ovulation in Women Undergoing Intrauterine Insemination Following Ovarian Stimulation.

J Hum Reprod Sci 2019 Jan-Mar;12(1):53-58

Department of Clinical Research and Pharmacovigilance, Bharat Serums and Vaccines Limited, Navi Mumbai, Maharashtra, India.

Context: A new indigenous recombinant human chorionic gonadotropin (r-hCG) has been developed in India with a comparable pharmacological profile to that of Ovitrelle (Merck Serono).

Aims: This study aims to compare the efficacy and safety of the new r-hCG with that of Ovitrelle for induction of ovulation in women undergoing intrauterine insemination (IUI).

Settings And Design: Randomized (2:1), multicenter, open-label, equivalence clinical trial conducted in India. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_101_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472201PMC

Evaluation of Oxidative Stress and Severity of Endometriosis.

J Hum Reprod Sci 2019 Jan-Mar;12(1):40-46

Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Aims: The aim was to evaluate the association between oxidative stress with the severity of endometriosis in blood and peritoneal fluid.

Settings And Design: This study was a prospective observational study conducted in the department of obstetrics and gynecology in a tertiary center over 2 years in patients with endometriosis requiring laparoscopy.

Methodology: Patients diagnosed with endometriosis and undergoing laparoscopy for infertility and/or chronic pelvic pain were included in the study. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_27_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472204PMC

Menstrual Blood versus Endometrial Biopsy in Detection of Genital Tuberculosis by Using Nested Polymerase Chain Reaction in an Endemic Region.

J Hum Reprod Sci 2019 Jan-Mar;12(1):35-39

Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Aim: The aim of this study is to compare the results of nested polymerase chain reaction (PCR) for early detection of genital tuberculosis (GTB) using menstrual blood (MB) and endometrial tissue (ET) as samples in females presenting as infertility.

Methods: The ET and MB samples were collected from a total of 194 females, enrolled in this study. DNA isolation from samples was done using standard, phenol-chloroform method. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_149_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472208PMC

Predominance of cervicitis agents with minimal testing rate within the student population in Benin city, Nigeria.

J Obstet Gynaecol 2019 Apr 22:1-5. Epub 2019 Apr 22.

c Department of Obstetrics and Gynaecology , Nnamdi Azikiwe University Teaching Hospital , Nnewi , Nigeria.

Here, we aimed to investigate the predominance of cervicitis agents with minimal testing rates among asymptomatic students in a Tertiary Institution and its associated risk factors. Endocervical swabs were collected from randomly selected 133 female students (15-34 years of age) in Benin City, Nigeria and screened for six genital pathogens (Chlamydia trachomatis, Mycoplasma hominis, M. genitalium, Ureaplasma urealyticum, U. Read More

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http://dx.doi.org/10.1080/01443615.2019.1584888DOI Listing

Fear of childbirth and associated factors among low-risk pregnant women.

J Obstet Gynaecol 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.

The aims of this study were to determine prevalence of childbirth fear among uncomplicated pregnant women in Siriraj Hospital and possible associated factors. A total of 305 uncomplicated, singleton pregnant women were enrolled during early third trimester. All participants were interviewed regarding baseline demographic, social, economic, family, and obstetric characteristics. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1584885DOI Listing
April 2019
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Accuracy of frozen section at early clinical stage of endometrioid endometrial cancer: a retrospective analysis in Germany.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Gynaecology and Obstetrics, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany.

Purpose: The aim of this study was to estimate the accuracy of intra-operative frozen section (FS) diagnosis during hysterectomy for early-stage endometrial cancer (EC).

Methods: At the Department of Obstetrics and Gynecology, University of Luebeck, between 2009 and 2014, the intra-operative FS pathology of 164 patients with pre-operative endometrial curettage, showing G1 or G2 endometrioid EC at an early clinical stage (FIGO I-II), was compared retrospectively with the final paraffin section reports. The accuracy of myometrial invasion (MI) in all patients and separately in stage FIGO I patients was calculated and the under- or overtreatment of the patients was analyzed. Read More

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http://dx.doi.org/10.1007/s00404-019-05158-0DOI Listing

Hidden blood loss and its risk factors in patients undergoing laparoscopy and laparotomy for cervical cancer management.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Gynaecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.

Purpose: Laparoscopy and laparotomy are the two most common surgical options used to treat women with early-stage cervical cancer. This study aimed to examine the volume of hidden blood loss (HBL) between laparoscopy and laparotomy for cervical cancer and to identify its risk factors.

Methods: Sixty-one patients treated with laparotomy and 50 patients treated with laparoscopy were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s00404-019-05162-4DOI Listing

A GCIG international survey: clinical practice patterns of sentinel lymph node biopsies in cervical cancer.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Gynecology With Center for Oncological Surgery, Charité Universtitätmedizin, Charité Platz 1, 10117, Berlin, Germany.

Purpose: To evaluate the practice patterns among centers and physicians worldwide regarding sentinel lymph node biopsies (SLNB) in cervical cancer (CC) patients.

Method: A validated 35-item questionnaire regarding SLNB in CC supported by the Gynecologic Cancer Intergroup (GCIG), and sponsored by the North-Eastern German Society of Gynaecologic-Oncology (NOGGO) was sent to all major gynecological cancer societies across the globe for further distribution from October 2015 and continued for a period of 7 months.

Results: One hundred and sixty-one institutions from around the world participated. Read More

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http://link.springer.com/10.1007/s00404-019-05164-2
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http://dx.doi.org/10.1007/s00404-019-05164-2DOI Listing
April 2019
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Nutrition in transition: historical cohort analysis summarising trends in under- and over-nutrition among pregnant women in a marginalised population along the Thailand-Myanmar border from 1986 to 2016.

Br J Nutr 2019 Apr 22:1-26. Epub 2019 Apr 22.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine,Mahidol University,Mae Sot, 63110,Thailand.

The objective of this study is to summarise trends in under- and over- nutrition in pregnant women on the Thailand-Myanmar border. Refugees contributed data from 1986-2016 and migrants from 1999-2016 for weight at first antenatal consultation. Body mass index (BMI) and gestational weight gain (GWG) data were available during 2004-2016 when height was routinely measured. Read More

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http://dx.doi.org/10.1017/S0007114519000758DOI Listing

Efficacy and safety of ultrasound-guided high-intensity focused ultrasound for uterine fibroids: a preliminary experience.

J Obstet Gynaecol 2019 Apr 22:1-7. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology , Queen Mary Hospital, The University of Hong Kong , Hong Kong , ROC.

The objective of this prospective cohort study was to evaluate the therapeutic efficacy and safety of ultrasound-guided high-intensity focussed ultrasound (HIFU) in the treatment of uterine fibroids. Twenty premenopausal women with symptomatic fibroids underwent ultrasound-guided HIFU therapy. Twenty-two fibroids with a median baseline volume of 127. Read More

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http://dx.doi.org/10.1080/01443615.2019.1581740DOI Listing

A review of reproductive outcomes of women with two consecutive miscarriages and no living child.

J Obstet Gynaecol 2019 Apr 22:1-6. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology , University College Cork , Cork , Ireland.

The definition of recurrent miscarriage ranges from two miscarriages according to the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology, to three consecutive pregnancy losses as defined by the Royal College of Obstetricians and Gynaecologists. Recent guidelines emphasise the need for further research on the effect of various recurrent miscarriage definitions on diagnosis, treatment and prognosis. Our study examines the management and pregnancy outcomes of nulliparous women attending Cork University Maternity Hospital's Pregnancy Loss Clinic, between 2009 and 2014, with their second consecutive first-trimester miscarriage. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1576600DOI Listing
April 2019
1 Read

Could implementation of mifepristone address Canada's urban-rural abortion access disparity: a mixed-methods implementation study protocol.

BMJ Open 2019 Apr 20;9(4):e028443. Epub 2019 Apr 20.

Department of Family & Community Medicine, University of Toronto, Toronto, Ontario, Canada.

Introduction: In January 2017, mifepristone-induced medical abortion was made available in Canada. In this study, we will seek to (1) understand facilitators and barriers to the implementation of mifepristone across Canada, (2) assess the impact of a 'community of practice' clinical and health service support platform and (3) engage in and assess the impact of integrated knowledge translation (iKT) activities aimed to improve health policy, systems and service delivery issues to enhance patient access to mifepristone.

Methods And Analysis: This prospective mixed-methods implementation study will involve a national sample of physicians and pharmacists recruited via an online training programme, professional networks and a purpose-built community of practice website. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028443DOI Listing

Screening and treatment to reduce severe hyperbilirubinaemia in infants in primary care (STARSHIP): a factorial stepped-wedge cluster randomised controlled trial protocol.

BMJ Open 2019 Apr 20;9(4):e028270. Epub 2019 Apr 20.

Division of Neonatology, Department of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medical Centre Rotterdam, Rotterdam, Netherlands.

Introduction: Jaundice caused by hyperbilirubinaemia is a physiological phenomenon in the neonatal period. However, severe hyperbilirubinaemia, when left untreated, may cause kernicterus, a severe condition resulting in lifelong neurological disabilities. Although commonly applied, visual inspection is ineffective in identifying severe hyperbilirubinaemia. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028270DOI Listing

Simple and novel technique for fabrication of prosthetic vaginal dilators.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, India.

Vaginal agenesis is one of the major congenital anomalies affecting women. Postoperative prosthetic vaginal dilators are indicated in patients treated surgically for vaginal agenesis. Although different dental materials such as acrylics and silicone-coated materials are used, addition silicones alone have never been used for the fabrication of prosthetic vaginal dilators. Read More

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http://dx.doi.org/10.1136/bcr-2019-229524DOI Listing

Single embryo transfer: Why and how to identify the embryo with the best developmental potential.

Authors:
Aila Tiitinen

Best Pract Res Clin Endocrinol Metab 2019 Apr 13. Epub 2019 Apr 13.

Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, FI-00029 Helsinki, Finland. Electronic address:

Multiple pregnancies with higher risk of preterm birth and the associated higher morbidity have been a major obstacle from the early days of in vitro fertilization. A good strategy to avoid multiple pregnancies is elective single embryo transfer and cryopreservation of spare embryos. Important factors in adopting this strategy are good counselling of the patients and the selection of embryos with high implantation potential. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X193001
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http://dx.doi.org/10.1016/j.beem.2019.04.001DOI Listing
April 2019
1 Read

Synthesis of Nomega-Nitro-l-arginine methyl ester modified reduced graphene oxide nanosheets and their protective action on experimental preeclampsia in mice.

J Photochem Photobiol B 2019 Mar 22;194:183-187. Epub 2019 Mar 22.

Department of Gynaecology and Obstetrics, Jinan Maternal and Child Health Hospital of Shandong Province, Shandong, China. Electronic address:

The purpose of this study is to synthesize Nomega-Nitro-L-arginine methyl ester (L-NAME) adsorbed reduced graphene oxide (RGO) sheets and demonstrate their protective impact on the detrimental effect detected in investigational pre-eclampsia, a prerequisite where increase in oxidative stress and decreased Nitric Oxide (NO) production were present. The synthesized graphene sheets were studies by using various characterization techniques. Later, a prerequisite similar to pre-eclampsia has been induced through chronic inhibition of NO fabrication using a 60 mg/kg/day L-NAME, orally in pregnant mice. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.03.013DOI Listing

Effect of postpartum glucose tolerance results on subsequent weight retention in women with recent gestational diabetes: a retrospective cohort study.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Women's College Research Institute, Women's College Hospital, Toronto, Canada; Institute of Health Policy, Management and Evaluation/Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada; Institute for Clinical Evaluative Sciences, Toronto, Canada; Sunnybrook Health Sciences Centre, Toronto, Canada. Electronic address:

Aims: Glucose tolerance normalizes postpartum in most women with gestational diabetes (GDM), which may provide false reassurance and decrease weight-reducing behaviours. We evaluated whether awareness of normal postpartum glucose tolerance was associated with higher weight retention than being unaware of glucose tolerance.

Methods: This cohort study of women with GDM collected survey data during pregnancy and in the first and second postpartum year. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.016DOI Listing

Correlation of fetal blood vessel Doppler measurements with fetal anemia among Rhesus isoimmunized pregnancies after two intrauterine transfusions.

Int J Gynaecol Obstet 2019 Apr 20. Epub 2019 Apr 20.

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

Objective: To assess the correlation between fetal blood vessel Doppler measurements and fetal anemia among Rhesus isoimmunized pregnancies after two intrauterine transfusions as a potential guide to therapy.

Methods: A prospective observational study was conducted among 30 women who attended a single hospital in India between April 2, 2015 and October 30, 2016. The participants underwent a third intrauterine transfusion based on a middle cerebral artery (MCA) peak systolic velocity (PSV) of greater than 1. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.12825
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http://dx.doi.org/10.1002/ijgo.12825DOI Listing
April 2019
1 Read

The pathophysiology of the septate uterus: a systematic review.

BJOG 2019 Apr 20. Epub 2019 Apr 20.

Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam.

Background: Little is known about the pathophysiology underlying the increased risk for impaired reproductive outcomes in women with a septate uterus.

Objectives: We explored the available evidence on the pathophysiology of the septate uterus in an attempt to find a biological basis for these effects.

Search Strategy: We performed a systematic literature search in OVID MEDLINE and OVID EMBASE from inception to January 2018. Read More

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http://dx.doi.org/10.1111/1471-0528.15798DOI Listing

The frequency of CNVs in a cohort population of consecutive fetuses with congenital anomalies after the termination of pregnancy.

Mol Genet Genomic Med 2019 Apr 19:e658. Epub 2019 Apr 19.

Clinical Institute of Medical Genetics (CIMG), University Medical Centre Ljubljana, Ljubljana, Slovenia.

Background: The implementation of molecular karyotyping has resulted in an improved diagnostic yield in the genetic diagnostics of congenital anomalies, detected prenatally or after the termination of pregnancy. However, the systematic epidemiologic ascertainment of copy number variations in the etiology of congenital anomalies has not yet been sufficiently explored.

Methods: Consecutive fetuses, altogether 204, with major single or multiple congenital anomalies were ascertained by using the SLOCAT registry for the period from 2011 to 2015. Read More

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http://dx.doi.org/10.1002/mgg3.658DOI Listing

Obstetric perineal tears: risk factors, wound infection and dehiscence: a prospective cohort study.

Arch Gynecol Obstet 2019 Apr 19. Epub 2019 Apr 19.

Department of Gynaecology and Obstetrics, Odense University Hospital, J.B. Winsløws Vej 4, 5000, Odense C, Denmark.

Purpose: To assess risk factors for perineal tears, wound infection and dehiscence among primiparous women.

Methods: A prospective cohort study at four Danish hospitals (Odense, Esbjerg, Aarhus and Kolding) among 603 primiparous women sampled in three groups: 203 with none/labia/1st degree, 200 with 2nd degree, and 200 with 3rd/4th degree tears included between July 2015 and January 2018. Baseline data were obtained and a clinical examination of perineal wound healing was performed 11-21 days postpartum. Read More

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http://link.springer.com/10.1007/s00404-019-05165-1
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http://dx.doi.org/10.1007/s00404-019-05165-1DOI Listing
April 2019
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Health of adults aged 22 to 35 years conceived by assisted reproductive technology.

Fertil Steril 2019 Apr 9. Epub 2019 Apr 9.

Hudson Institute of Medical Research, Clayton, Victoria, Australia; Monash IVF Group Pty Ltd, Richmond, Victoria, Australia; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

Objective: To determine the health outcomes for adults aged 22-35 years old who were conceived via assisted reproduction technology (ART) compared with adults of the same age conceived without use of ART.

Design: Cohort study.

Setting: Not applicable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282193024
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http://dx.doi.org/10.1016/j.fertnstert.2019.03.001DOI Listing
April 2019
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Predictive accuracy of the breast cancer genetic risk model based on eight common genetic variants: The BACkSIDE study.

J Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava (JFMED UK), Slovakia.

Breast cancer (BC) development is caused by the interaction of environmental and genetic factors. At least 90 susceptible genetic variants with different population penetration and incidence have been associated with BC. This paper therefore analysed the individual discrimination power of 8 low penetrant common genetic variants and calculated the predictive accuracy of the genetic risk model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681656193012
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http://dx.doi.org/10.1016/j.jbiotec.2019.04.014DOI Listing
April 2019
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ARPC2 promotes breast cancer proliferation and metastasis.

Oncol Rep 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Actin-related protein 2/3 complex (ARPC2) is an actin‑binding component involved in the regulation of actin polymerization. It mediates the formation of branched actin networks and contacts the mother actin filament. Migration and invasion are key processes which enable tumor cells to infiltrate blood vessels or lymphatic vessels, and the actin pathway plays a very important role. Read More

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http://dx.doi.org/10.3892/or.2019.7113DOI Listing
April 2019
4 Reads

Spontaneous preterm recurrent fundal uterine rupture at 26 weeks following laparoscopic myomectomy.

J Obstet Gynaecol 2019 Apr 19:1-2. Epub 2019 Apr 19.

b Department of Obstetrics and Gynaecology , North Middlesex University Hospital , London , UK.

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http://dx.doi.org/10.1080/01443615.2018.1557124DOI Listing

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Cancer Med 2019 Apr 18. Epub 2019 Apr 18.

Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.

An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.1996
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http://dx.doi.org/10.1002/cam4.1996DOI Listing
April 2019
2 Reads

Juvenile Papillomatosis: A Case Report.

Eur J Breast Health 2019 Apr 15;15(2):130-134. Epub 2019 Feb 15.

Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.

Juvenile papillomatosis of the breast, also known as Swiss cheese disease, is a rare and benign proliferative disorder affecting young women. These patients tend to have a strong family history of cancer. The lesion typically presents as a localized mass without sharp borders. Read More

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http://dx.doi.org/10.5152/ejbh.2019.4362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456279PMC

Longitudinal Analysis Between Maternal Feeding Practices and Body Mass Index (BMI): A Study in Asian Singaporean Preschoolers.

Front Nutr 2019 2;6:32. Epub 2019 Apr 2.

Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore, Singapore.

Bidirectional studies between maternal feeding practices with subsequent child weight are limited, with no studies in Asian populations. In longitudinal analyses, we assessed the directionality of the associations between maternal feeding practices and body mass index (BMI) in preschoolers. Participants were 428 mother child dyads from the GUSTO (Growing Up in Singapore Toward healthy Outcomes) cohort. Read More

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https://www.frontiersin.org/article/10.3389/fnut.2019.00032/
Publisher Site
http://dx.doi.org/10.3389/fnut.2019.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454195PMC
April 2019
2 Reads

Design and Workspace Analysis of a Parallel Ankle Rehabilitation Robot (PARR).

J Healthc Eng 2019 14;2019:4164790. Epub 2019 Mar 14.

College of Mechanical Engineering and Applied Electronics Technology, Beijing University of Technology, Beijing, China.

The ankle rehabilitation robot is essential equipment for patients with foot drop and talipes valgus to make up deficiencies of the manual rehabilitation training and reduce the workload of rehabilitation physicians. A parallel ankle rehabilitation robot (PARR) was developed which had three rotational degrees of freedom around a virtual stationary center for the ankle joint. The center of the ankle should be coincided with the virtual stationary center during the rehabilitation process. Read More

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https://www.hindawi.com/journals/jhe/2019/4164790/
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http://dx.doi.org/10.1155/2019/4164790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437750PMC
March 2019
2 Reads

Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit.

Front Psychol 2019 2;10:715. Epub 2019 Apr 2.

Centre National de la Recherche Scientifique, Institute for Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, France.

Preterm infants (PTI) typically experience many painful and stressful procedures or events during their first weeks of life in a neonatal intensive care unit, and these can profoundly impact subsequent brain development and function. Several protective interventions during this sensitive period stimulate the oxytocin system, reduce pain and stress, and improve brain development. This review provides an overview of the environmental risk factors experienced by PTI during hospitalization, with a focus on the effects of pain, and early maternal separation. Read More

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https://www.frontiersin.org/article/10.3389/fpsyg.2019.00715
Publisher Site
http://dx.doi.org/10.3389/fpsyg.2019.00715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454868PMC
April 2019
1 Read

Synchronous Primary Malignancy of Female Genital Tract: A Report of Two Cases and Review of Literature.

J Midlife Health 2019 Jan-Mar;10(1):51-54

Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Synchronous primary tumors of female genital tract is a rare phenomenon. We present two cases of anatomically related yet histologically unrelated tumors. The first patient is a 57 years postmenopausal female with synchronous low grade papillary urothelial carcinoma of the bladder and endometrioid adenocarcinoma of the endometrium. Read More

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http://dx.doi.org/10.4103/jmh.JMH_138_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459065PMC

Anastomosing Hemangioma of the Ovary Clinically Masquerading as Epithelial Malignancy: A Rare Case Report.

J Midlife Health 2019 Jan-Mar;10(1):48-50

Department of Pathology, Chettinad Hospital and Research Institute, Kanchipuram, Tamil Nadu, India.

Anastomosing hemangioma (AH) is a rare vascular tumor, which has a predilection for the genitourinary system. Ovarian AH is rare, only few cases have been reported in literature so far. Here, we report a case of 50-year-old woman with right ovarian mass clinically diagnosed as ovarian epithelial malignancy. Read More

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http://dx.doi.org/10.4103/jmh.JMH_121_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459067PMC

Prevalence of Depression and its Association with Sociodemographic Factors in Postmenopausal Women in an Urban Resettlement Colony of Delhi.

J Midlife Health 2019 Jan-Mar;10(1):33-36

Department of Obstetrics and Gynaecology, Maulana Azad Medical College, Delhi, India.

Background: Menopause is defined as the time of cessation of ovarian function resulting in permanent amenorrhea. Menopause is associated with various symptoms such as physical, vasomotor, sexual, and psychological symptoms. Depression is a common symptom in postmenopausal women as menopause is associated with the end of the fertile period of a women's life. Read More

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http://www.jmidlifehealth.org/text.asp?2019/10/1/33/255280
Publisher Site
http://dx.doi.org/10.4103/jmh.JMH_66_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459070PMC
April 2019
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The use of chemotherapeutic agents as prophylaxis for recurrent urinary tract infection in healthy nonpregnant women: A network meta-analysis.

Indian J Urol 2019 Apr-Jun;35(2):147-155

Department of Obstetrics and Gynaecology, International Medical University Clinical Campus Seremban, Negeri Sembilan, Malaysia.

Introduction: The aim of this systematic review is to compare chemotherapeutic agents commonly used in treating recurrent urinary infection in nonpregnant women by their efficacy, tolerability, adverse effects, and cost employing network meta-analysis.

Materials And Methods: We used three online databases, i.e. Read More

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http://dx.doi.org/10.4103/iju.IJU_378_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458811PMC
April 2019
2 Reads

Identifying optimal clinical scenarios for synchrotron microbeam radiation therapy: A treatment planning study.

Phys Med 2019 Apr 30;60:111-119. Epub 2019 Mar 30.

Alfred Health Radiation Oncology, Alfred Health, Melbourne, Victoria 3004, Australia; Department of Surgery, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia. Electronic address:

Purpose: Synchrotron Microbeam Radiation Therapy (MRT) is a pre-clinical modality characterised by spatial dose fractionation on a microscopic scale. Treatment planning studies using clinical datasets have not yet been conducted. Our aim was to investigate MRT dose-distributions in scenarios refractory to conventional treatment and to identify optimal settings for a future Phase I trial. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.03.019DOI Listing

Exploring the effect of implementation and context on a stepped-wedge randomised controlled trial of a vital sign triage device in routine maternity care in low-resource settings.

Implement Sci 2019 Apr 18;14(1):38. Epub 2019 Apr 18.

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, SE1 7EH, UK.

Background: Interventions aimed at reducing maternal mortality are increasingly complex. Understanding how complex interventions are delivered, to whom, and how they work is key in ensuring their rapid scale-up. We delivered a vital signs triage intervention into routine maternity care in eight low- and middle-income countries with the aim of reducing a composite outcome of morbidity and mortality. Read More

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https://implementationscience.biomedcentral.com/articles/10.
Publisher Site
http://dx.doi.org/10.1186/s13012-019-0885-3DOI Listing
April 2019
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Sero-epidemiological status and risk factors of toxoplasmosis in pregnant women in Northern Vietnam.

BMC Infect Dis 2019 Apr 18;19(1):329. Epub 2019 Apr 18.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

Background: In Vietnam, few studies have determined the epidemiological status of toxoplasmosis in pregnant women and no routine prenatal screening is in place. This study was conducted to evaluate the seroprevalence of this zoonotic parasitic infection in pregnant women in Northern Vietnam and to assess the association with awareness, risk factors and congenital toxoplasmosis.

Methods: Approximately 800 pregnant women were included in the study from two hospitals, one in Hanoi and one in Thai Binh province, which is known to have a dense cat population. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-019-3885-7DOI Listing
April 2019
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A rare case of delayed vaginal vault dehiscence with evisceration causing pneumatosis intestinalis.

J Obstet Gynaecol 2019 Apr 19:1-2. Epub 2019 Apr 19.

a Obstetrics and Gynaecology , Basingstoke and North Hampshire Hospital , Basingstoke , UK.

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
Publisher Site
http://dx.doi.org/10.1080/01443615.2019.1573886DOI Listing
April 2019
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Management of caesarean scar pregnancy with high dose intravenous methotrexate infusion therapy: 10-year experience at a single tertiary centre.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 9;237:28-32. Epub 2019 Apr 9.

Women's and Newborn Services, Royal Brisbane and Women's Hospital, Herston, Australia.

Objective: Incidence of caesarean scar pregnancy (CSP) is increasing due to rising caesarean section rate and advanced imaging modalities. At present, there is no consensus to recommend any specific intervention. In our centre, we have adopted the high dose intravenous methotrexate therapy followed by folinic acid for the management of CSP. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.008DOI Listing
April 2019
1 Read

Effect of the competency-based (HMS BAB) training on maternal morbidity: a cluster-randomised trial in 20 districts in Tanzania.

BMJ Glob Health 2019 7;4(2):e001214. Epub 2019 Mar 7.

Department of Public Health Sciences, Karolinska Institutet, Solna, Sweden.

Background: Training health providers is an important strategy to improve health. We conducted a cluster-randomised two-arm trial in Tanzania to assess the effect of a 1-day competency-based training 'Helping Mothers Survive Bleeding after Birth (HMS BAB)' followed by eight weekly drills on postpartum haemorrhage (PPH)-related morbidity and mortality.

Methods: Twenty districts in four purposefully selected regions in Tanzania included 61 facilities. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-001214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441296PMC

Spontaneous chorioamniotic membrane separation discovered by preterm prelabor rupture of membranes.

Clin Case Rep 2019 Apr 6;7(4):762-765. Epub 2019 Mar 6.

Department of Gynaecology Universitair Ziekenhuis Antwerpen Edegem Belgium.

Chorioamniotic membrane separation (CMS) is a rare finding in ultrasound examination during pregnancy. It is mostly seen as a complication after invasive prenatal procedures but also can present spontaneously. Extensive CMS is found to be associated with adverse perinatal fetal outcomes. Read More

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http://dx.doi.org/10.1002/ccr3.2083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452456PMC

Population-based study of early-onset neonatal sepsis in Canada.

Paediatr Child Health 2019 May 24;24(2):e66-e73. Epub 2018 Apr 24.

Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario.

Objective: To determine the incidence, types of organisms and resistance patterns involved in early-onset neonatal sepsis in Canada.

Study Design: Early-onset neonatal sepsis cases were identified through the Canadian Paediatric Surveillance Program. Neonates were excluded if they were asymptomatic or if intracranial procedures preceded a positive cerebrospinal fluid culture. Read More

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https://academic.oup.com/pch/article/24/2/e66/4983126
Publisher Site
http://dx.doi.org/10.1093/pch/pxy018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462127PMC
May 2019
1 Read