322,489 results match your criteria Obstetrical & Gynecological Survey[Journal]


Risk factors for pelvic and distant recurrence in locally advanced cervical cancer.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 6;235:6-12. Epub 2019 Feb 6.

Medical Oncology Department, A.C. Camargo Cancer Center, São Paulo, SP, Brazil. Electronic address:

Objective: Despite the benefits of concomitant radiotherapy and cisplatin for locally advanced cervical cancer, recurrence rates remain high. New treatment strategies such as consolidation chemotherapy and different concomitant chemotherapy combinations have been tested in recent years. Identification of the best candidates for each treatment strategy could optimize results. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.028DOI Listing
February 2019

The effects of a childbirth preparation course on birth outcomes among nulliparous Jordanian women.

Midwifery 2019 Feb 7;72:23-29. Epub 2019 Feb 7.

Faculty of Nursing, Jordan University of Science and Technology, B.O. Box 3030, Irbid 22110, Jordan. Electronic address:

Objective: This study aimed to examine the effectiveness of a childbirth preparation course on birth outcomes among nulliparous Jordanian women.

Design: A randomized control trial pre-test/post-test design was used to assess the effects of a childbirth preparation course conducted in a military hospital in Amman, Jordan from 1 July to 15 September 2016. A total of 133 low-risk nulliparous women were recruited and randomly assigned to either (1) a control group who received standard care in antenatal clinics or (2) an intervention group who received standard care in antenatal clinics as well as a childbirth preparation course specifically designed for the purpose of this study. Read More

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http://dx.doi.org/10.1016/j.midw.2019.02.002DOI Listing
February 2019

Mobile obstetric and neonatal simulation based skills training in India.

Midwifery 2019 Feb 7;72:14-22. Epub 2019 Feb 7.

Department of Paediatrics, Monash University, Melbourne, Australia.

Background: The developing world has a significantly high risk of women and babies dying during childbirth. Interprofessional simulation training has improved birth practices and outcomes by impacting clinical and non-technical skills like communication, teamwork, leadership and effective use of resources. While these programs have become a training requirement in many high-income countries, they have not been widely introduced in the low-income, low-resource settings. Read More

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http://dx.doi.org/10.1016/j.midw.2019.02.006DOI Listing
February 2019

Pregnancy outcomes after maternal Zika virus infection in a non-endemic region: prospective cohort study.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Maternal Fetal Medicine Unit. Department of Obstetrics. Hospital Universitari Vall d'Hebron. Ps. Vall d'Hebron 119-129, 08035 Barcelona. Universitat Autònoma de Barcelona.

Objectives: to describe pregnancy outcomes after Zika virus (ZIKV) infection in a non-endemic region.

Methods: according to the Spanish protocol issued after the ZIKV outbreak in Brazil in 2015, all pregnant women who had travelled to high-burden countries were screened for ZIKV. Serological and molecular tests were used to identify ZIKV-infected pregnant women. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.008DOI Listing
February 2019

The Combination of MEK inhibitor with Immunomodulatory Antibodies Targeting PD-1 and PD-L1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Section of Medical Oncology, Department of Internal Medicine; Developmental Therapeutics Translational Research Program, Yale Comprehensive Cancer Center, New Haven, Connecticut , USA. Electronic address:

Purpose: To characterize the tumor-infiltrating immune cells population in Kras/p53-driven lung tumors and to evaluate the combinatorial anti-tumor effect with MEK inhibitor (MEKi), trametinib, and immunomodulatory monoclonal antibodies (mAbs) targeting either programmed cell death protein-1 (PD-1) or programmed cell death protein ligand 1 (PD-L1) in vivo.

Experimental Design: Trp53;Kras;Rosa26 (PKL) genetically engineered mice were utilized to develop autochthonous lung tumors with intratracheal delivery of adenoviral Cre recombinase. Using these tumor-bearing lungs, tumor-infiltrating immune cells were characterized by both mass cytometry and flow cytometry. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.004DOI Listing
February 2019

The Trend, Feasibility, and Safety of Salpingectomy as a form of Permanent Sterilization.

J Minim Invasive Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics & Gynecology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston TX, USA.

Study Objectives: To assess the change in rate of laparoscopic salpingectomy for sterilization after the release of the November 2013 Society of Gynecologic Oncology (SGO) Clinical Practice Statement and the January 2015 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion: Salpingectomy for Ovarian Cancer Prevention. We hypothesized there would be an increase in salpingectomy as a percentage of total laparoscopic sterilizations performed without an increase in complications when compared to conventional bilateral tubal ligation (BTL).

Design: A retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.02.003DOI Listing
February 2019

SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy; Infertility Service, San Salvatore Hospital, L'Aquila 67100, L'Aquila, Italy. Electronic address:

Methylglyoxal (MG), a highly reactive dicarbonyl derived from metabolic processes, is the most powerful precursor of advanced glycation end products (AGEs). Glycative stress has been recently associated with ovarian dysfunctions in aging and PCOS syndrome. We have investigated the role of the NAD-dependent Class III deacetylase SIRT1 in the adaptive response to MG in mouse oocytes and ovary. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.011DOI Listing
February 2019

TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Translational Epigenetics Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

DNA hypermethylation is a driving force in carcinogenesis. However, the role of active DNA hypomethylation in cancer remains largely unknown. This process, facilitated by ten-eleven translocation methylcytosine dioxygenase 1 (TET1), which oxidizes 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), has never been studied in cervical cancer. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.033DOI Listing
February 2019

Gynecologic Cancer in HIV-Positive Women: a Systematic Review and Meta-analysis.

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD; The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address:

Objective: While there is a significant body of literature on cervical cancer in HIV-positive women, little is known about other gynecologic cancers in this population. The objective of this systematic review and meta-analysis is to describe the incidence, presentation, treatment, and outcomes for HIV-positive women with non-AIDS-defining gynecologic cancers.

Data Source: We searched Medline, Embase, ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.022DOI Listing
February 2019

Reply to Letter # L19-004AR1.

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Northwestern, University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1016/j.ajog.2019.02.020DOI Listing
February 2019

Study of contraceptive Mobile app fails to provide convincing findings.

Contraception 2019 Feb 13. Epub 2019 Feb 13.

green-ivf, Grevenbroich Endocrinology and IVF-Center & Department of Gynecology and Obstetrics University of Cologne (Director: Prof. Dr. Peter Mallmann).

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http://dx.doi.org/10.1016/j.contraception.2018.07.141DOI Listing
February 2019

Impact of intertwin interval on short-term neonatal outcomes of the second twin in dichorionic pregnancies with vaginal delivery.

Int J Gynaecol Obstet 2019 Feb 16. Epub 2019 Feb 16.

Department of Obstetrics, Hospital Universitario Materno-Infantil Miguel Servet, Zaragoza, Spain.

Objective: To examine the effect of intertwin interval on umbilical cord pH and Apgar scores of the second twin after vaginal delivery.

Methods: A retrospective study of twin deliveries at a university hospital in Spain between August 2012 and September 2017. Inclusion criteria were vaginal delivery of both twins at 32 gestational weeks or more. Read More

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http://dx.doi.org/10.1002/ijgo.12790DOI Listing
February 2019

The importance of non-technical performance for teams managing postpartum haemorrhage: video review of 99 obstetric teams.

BJOG 2019 Feb 16. Epub 2019 Feb 16.

School of Applied Psychology, University of Applied Sciences and Arts Northwestern Switzerland, Switzerland.

Objective: Little is known about how teams' non-technical performance influences clinical performance in obstetric emergencies like postpartum haemorrhage.

Design: Video review - observational study.

Setting: A university hospital (5,000 deliveries) and a regional hospital (2,000 deliveries) in Denmark. Read More

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http://dx.doi.org/10.1111/1471-0528.15655DOI Listing
February 2019

Placental Growth Factor Blunts Uterine Artery Responses to Angiotensin II.

BJOG 2019 Feb 16. Epub 2019 Feb 16.

Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital-Pavilion for Women, Houston, TX, United States.

Objective: Changes in maternal serum concentration of placental growth factor (PlGF) and vascular response to intravascular infusion of Angiotensin II (Ang II) follow a bell-shaped curve pattern during gestation. This study evaluates the effects of PlGF and soluble vascular endothelial growth factor receptor-1 (sFlt-1) on responses of human uterine arteries (UA) to Ang II.

Design: Experimental. Read More

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http://dx.doi.org/10.1111/1471-0528.15656DOI Listing
February 2019

The efficacy of misoprostol vaginal insert compared with oral misoprostol in the induction of labor of nulliparous women: a randomized national multicenter trial.

Acta Obstet Gynecol Scand 2019 Feb 16. Epub 2019 Feb 16.

Tampere University hospital, Department of Obstetrics and Gynecology, Tampere, Finland.

Introduction: Our objective was to compare the efficacy of a 200-μg misoprostol vaginal insert (MVI) vs oral misoprostol regarding the cesarean section rate and the time interval to vaginal delivery in nulliparous women with unfavorable cervix.

Material And Methods: In this prospective multicenter trial 283 nulliparous women at term with Bishop score < 6 were randomized to induction of labor with either an MVI (n=140) or oral misoprostol (n= 143). Oral misoprostol was administered 50 μg four-hourly up to three times during the first day and 100 μg four-hourly up to three times during the second day, if necessary. Read More

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http://dx.doi.org/10.1111/aogs.13580DOI Listing
February 2019

Emergency Department Patients are Receptive to Prayer-Based Interventions to Reduce Alcohol Use.

J Relig Health 2019 Feb 15. Epub 2019 Feb 15.

Center for Policy & Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health & Science University, Portland, OR, USA.

Previous studies show that elements of spirituality, including prayer and religious services, may contribute to reductions in harmful alcohol use. The objective of this study was to assess the acceptability of prayer as a component of emergency department (ED) interventions for risky alcohol use. A 12-question multiple-choice questionnaire was developed, piloted, and refined by the study team. Read More

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http://dx.doi.org/10.1007/s10943-019-00779-wDOI Listing
February 2019

Visual inspection of transvaginal ultrasound videos to characterize uterine peristalsis: an inter-observer agreement study.

J Ultrasound 2019 Feb 15. Epub 2019 Feb 15.

Department of Electrical Engineering (Signal Processing Systems: Biomedical Diagnostics), Faculty of Electrical Engineering, Eindhoven Technical University, FLUX Room 7.078, Postbox 513, 5600 MB, Eindhoven, The Netherlands.

Purpose: Contractions in non-pregnant uterine can be assessed by visual inspection of transvaginal ultrasound (TVUS). Many authors have used this method to extract features like contraction frequency and direction. However, visual inspection is a subjective method and the outcome is dependent on the sonographers and video analysts. Read More

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http://dx.doi.org/10.1007/s40477-018-00356-zDOI Listing
February 2019

Oncologic and reproductive outcomes of cystectomy as a fertility-sparing treatment for early-stage epithelial ovarian cancer.

Int J Clin Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Nagoya University, Truma-cho 65, Showa-ku, 466-8550, Nagoya, Japan.

Background: Fertility-sparing surgery (FSS) has mainly been chosen for young women with ovarian-confined/well-differentiated epithelial ovarian cancer (EOC). In general, FSS consists of at least conservation of contralateral ovary and the uterus with a staging surgery. However, information on the clinical outcome in women who underwent cystectomy as a fertility-preserving option is lacking. Read More

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http://dx.doi.org/10.1007/s10147-019-01416-yDOI Listing
February 2019

Risk of adverse pregnancy outcomes by pre-pregnancy Body Mass Index among Italian population: a retrospective population-based cohort study on 27,807 deliveries.

Arch Gynecol Obstet 2019 Feb 15. Epub 2019 Feb 15.

Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC) Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Purpose: To estimate the impact of increasing pre-pregnancy Body Mass Index (BMI) on the risk of adverse maternal and perinatal outcomes, in patients who delivered in an Italian tertiary care Obstetric department.

Methods: Data, related to women who delivered at Sant'Anna Hospital, Turin, between 2011 and 2015, were collected retrospectively from the hospital database. According to BMI, women were considered as normal weight, overweight, and class 1, 2 and 3 obese (WHO criteria). Read More

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http://dx.doi.org/10.1007/s00404-019-05093-0DOI Listing
February 2019

Investigation of Urinary Sestrin2 in Patients with Obstructive Sleep Apnea.

Lung 2019 Feb 15. Epub 2019 Feb 15.

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.

Background: Obstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Sestrin2 is a crucial factor involved in oxidative stress. Read More

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http://dx.doi.org/10.1007/s00408-019-00205-8DOI Listing
February 2019

Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes.

Mol Hum Reprod 2019 Feb 16. Epub 2019 Feb 16.

Department of Obstetrics and Gynaecology and Gynaecology Research Centre, Royal Women's Hospital, University of Melbourne, Parkville, Victoria, Australia.

Endometriotic lesions are composed in part of endometrial-like stromal cells, however, there is a shortage of immortalized human endometrial stromal cultures available for research. As genetic factors play a role in endometriosis risk, it is important that genotype is also incorporated into analysis of pathological mechanisms. Human telomerase reverse transcriptase (hTERT) immortalization (using Lenti-hTERT-green fluorescent protein virus) took place following genotype selection; 13 patients homozygous for either the risk or non-risk 'other' allele for one or more important endometriosis risk single nucleotide polymorphism on chromosome 1p36. Read More

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http://dx.doi.org/10.1093/molehr/gaz006DOI Listing
February 2019

Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion.

Stem Cell Res Ther 2019 Feb 15;10(1):61. Epub 2019 Feb 15.

Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling of Liaoning Province, Reproductive Medicine Center, Obstetrics and Gynecology Department, Shengjing Hospital affiliated to China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang, Liaoning, China.

Background: Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregnancy and endometrium regeneration. We also initiated platelet-rich plasma (PRP) acted as a beneficial supplement in MenSC culturing and a potential endometrial receptivity regulator. Read More

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http://dx.doi.org/10.1186/s13287-019-1155-7DOI Listing
February 2019

Identification of novel candidate indicators for assessing zinc status during pregnancy in mice from microarray data.

BMC Pharmacol Toxicol 2019 Feb 15;20(1):12. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, PLA Army General Hospital, No.5 Nanmencang, Dongcheng District, Beijing, 100700, China.

Background: This study aimed to identify potential zinc status indicators and to clarify the mechanisms underlying zinc deficiency-induced organ damage and mortality in mice.

Methods: The dataset GSE97112, including placental tissues of mice fed diets containing normal and low concentrations of zinc, was downloaded and preprocessed. Differentially expressed genes (DEGs) were calculated and identified for zinc deficiency-related gene clusters by using the weighed gene co-expression network analysis (WGCNA) algorithm. Read More

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http://dx.doi.org/10.1186/s40360-019-0288-8DOI Listing
February 2019

Reproductive cancer risk factors among relatives of cancer patients in a tertiary oncology center.

BMC Cancer 2019 Feb 15;19(1):154. Epub 2019 Feb 15.

Department of preventive Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.

Background: The aim of this study was to evaluate the prevalence of some gynecological cancer risk factors in a population of female relatives of cancer patients in Hacettepe University Oncology Hospital. Additionally, what are the levels of the women's awareness /behavior toward available screening tools?

Methods: An individual cancer risk assessment questionnaire has been developed in the Department of Preventive Oncology, which questions the medical history, health behaviors and cancer awareness, as well as their behavior toward available cancer screening tools.

Results: The mean age of the study population was 45. Read More

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http://dx.doi.org/10.1186/s12885-019-5350-9DOI Listing
February 2019

Expression pattern of microRNAs related with response to trastuzumab in breast cancer.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Although an immense effort has been made to develop a novel biomarker for response to trastuzumab, no reliable biomarkers are available to guide management, expect for HER2. The aim of this study was to examine the relationship between microRNA (miRNA) expression and resistance to trastuzumab.

Methods: Differentially expressed miRNAs between trastuzumab-resistant and trastuzumab-sensitive cell lines were analyzed using microarrays. Read More

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http://dx.doi.org/10.1002/jcp.28268DOI Listing
February 2019

Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Division of Nutritional Sciences, Cornell University, Ithaca, NY.

Background: It has been proposed that the fetus prioritizes iron for hemoglobin production over delivery to tissues. However, few studies have evaluated the interrelations between hemoglobin and multiple iron status biomarkers in umbilical cord blood. A full understanding is needed of how these parameters influence each other within cord blood to fully interpret iron and hematologic status at birth. Read More

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http://dx.doi.org/10.1093/jn/nxy286DOI Listing
February 2019

Autoimmune Regulator (AIRE) is required in female mice for optimal embryonic development and implantation1.

Biol Reprod 2019 Feb 16. Epub 2019 Feb 16.

Dept. Pathobiology & Diagnostic Investigation, and.

Autoimmune Regulator (AIRE) regulates central immune tolerance by inducing expression of tissue-restricted antigens in thymic medullary epithelial cells, thereby ensuring elimination of autoreactive T cells. Aire mutations in humans and targeted Aire deletion in mice results in multi-organ autoimmune disease, known in humans as Autoimmune Polyglandular Syndrome Type 1 (APS-1). APS-1 is characterized by presence of adrenal insufficiency, chronic mucosal candidiasis, and/or hypoparathyroidism. Read More

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http://dx.doi.org/10.1093/biolre/ioz023DOI Listing
February 2019

Bladder Distension Injury Secondary to Postpartum Urinary Retention.

J Obstet Gynaecol Can 2019 Feb 12. Epub 2019 Feb 12.

Division of Urogynecology, Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON.

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http://dx.doi.org/10.1016/j.jogc.2018.05.001DOI Listing
February 2019

Screening for substance use in pregnancy and the newborn.

Semin Fetal Neonatal Med 2019 Feb 5. Epub 2019 Feb 5.

Department Obstetrics & Gynecology and Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

Substance use during pregnancy is common, costly and associated with maternal and newborn health consequences. Assessment of substance use should be integrated into prenatal care. Substance use identification methods include patient interview, screening instruments, and biological testing. Read More

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http://dx.doi.org/10.1016/j.siny.2019.01.007DOI Listing
February 2019

Hormonal medication in medically assisted reproduction: a systematic review of assessments from patients.

Reprod Biomed Online 2019 Jan 19. Epub 2019 Jan 19.

Centre for Reproductive Medicine, Women's and Children's Hospital, Academic Medical Centre, University of Amsterdam Amsterdam, the Netherlands; University of Leuven, Department of Development and Regeneration, Leuven, Belgium; University of Leuven, Department of Public Health and Primary Care, Leuven, Belgium; Research Foundation Flanders, Belgium. Electronic address:

Several hormonal fertility medications have comparable effectiveness. A literature review was conducted into patients' assessments regarding seven medication characteristics including 'side effects' and 'ease of use'. Medline, CINAHL and PsycINFO were searched for female fertility patients' written assessments of a hormonal medication. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.12.047DOI Listing
January 2019

Management of fetal tumors.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 14. Epub 2019 Jan 14.

Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada. Electronic address:

In this review article, we discuss the most common fetal tumors, their prenatal management, and outcomes. Overall, the most important outcome predictors are tumor histology, size, vascularity, and location. Very large lesions, lesions causing cardiac failure, and hydrops and lesions obstructing the fetal airway have the poorest outcome, as they may cause fetal death or complications at the time of delivery. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.01.006DOI Listing
January 2019

Vacuum Extraction in Preterm Deliveries and Long-Term Neurological Outcome of the Offspring.

Pediatr Neurol 2019 Jan 15. Epub 2019 Jan 15.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.

Background: Concern exists regarding a possible harmful impact of vacuum extraction on the preterm newborn. We aimed to evaluate the long-term pediatric neurodevelopmental outcomes of the preterm offspring after vacuum extraction.

Methods: A population-based cohort analysis was performed comparing the risk for long-term neurological morbidity (up to age 18 years) in preterm (less than 37 completed weeks of gestation) children born via following three delivery modes: vacuum extraction, spontaneous delivery, and cesarean delivery performed during the second stage of labor. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.010DOI Listing
January 2019

Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8 T Cell Responses.

Immunity 2019 Feb 6. Epub 2019 Feb 6.

Institute of Immunology and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address:

Systemic immunosuppression greatly affects the chemotherapeutic antitumor effect. Here, we showed that CD19 extracellular vesicles (EVs) from B cells through CD39 and CD73 vesicle-incorporated proteins hydrolyzed ATP from chemotherapy-treated tumor cells into adenosine, thus impairing CD8 T cell responses. Serum CD19 EVs were increased in tumor-bearing mice and patients. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.010DOI Listing
February 2019

Imaging of postoperative endometriosis.

Diagn Interv Imaging 2019 Feb 12. Epub 2019 Feb 12.

Department of Radiology, Hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.

Endometriosis is a chronic gynecological condition that affects primarily young women. Imaging plays a pivotal role for the diagnosis and pre-surgical mapping of the disease. By comparison, the role of imaging in the identification of disease recurrence and postoperative complications are not well established. Read More

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http://dx.doi.org/10.1016/j.diii.2018.11.003DOI Listing
February 2019

Maternal respiratory distress and successful reversal with sugammadex during intrauterine transfusion with fetal paralysis.

Int J Obstet Anesth 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics and Gynaecology, IWK Health Centre, Halifax, Nova Scotia, Canada.

A 70 kg, 34-year-old woman at 29 weeks-of-gestation required intrauterine transfusion for Rh (D) alloimmunization. In the ambulatory treatment clinic, 19 mg of rocuronium was administered intramuscularly in split doses into the fetal buttock. The fetus moved and inadvertent maternal neuromuscular blockade occurred, leading to respiratory distress. Read More

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http://dx.doi.org/10.1016/j.ijoa.2019.01.002DOI Listing
January 2019

Clitoral Phimosis: Effects on Female Sexual Function and Surgical Treatment Outcomes.

J Sex Med 2019 Feb;16(2):257-266

Department of Obstetrics and Gynecology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu 84, Prague 5, Czech Republic; Institute of Sexology, 1st Medical Faculty, Charles University, Ke Karlovu 460/11, Prague 2, Czech Republic. Electronic address:

Background: Surgery is the optimal treatment for a severe form of clitoral phimosis (CP) that is initiated by lichen sclerosus (LS) and causes female sexual dysfunction.

Aim: We aimed to determine the etiology of clitoral phimosis, its influence on sexual function, and outcomes after surgical treatment.

Methods: In this prospective cohort study, we observed the occurrence of clitoral phimosis and related changes in a group of 3,650 sexually active heterosexual women with a mean age of 34. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.012DOI Listing
February 2019

The Woman's Body (Not the Man's One) Is Used to Evaluate Sexual Desire: An Eye-Tracking Study of Automatic Visual Attention.

J Sex Med 2019 Feb;16(2):195-202

Quality of Care Unit, University Hospitals of Geneva, Geneva, Switzerland; Department of General Internal Medicine, Rehabilitation and Geriatrics, University of Geneva, Geneva, Switzerland; Swiss NCCR "LIVES-Overcoming Vulnerability: Life Course Perspectives", University of Geneva, Geneva, Switzerland.

Introduction: Vision of the human body has been shown to be key in eliciting sexual desire. However, whether the visual pattern characterizing sexual desire is different in women and men is still unclear.

Aim: To investigate the effect of gender on visual patterns triggered by an identical set of stimuli depicting attractive heterosexual couples. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.003DOI Listing
February 2019

Dietary Patterns during Pregnancy Are Associated with the Risk of Gestational Diabetes Mellitus: Evidence from a Chinese Prospective Birth Cohort Study.

Nutrients 2019 Feb 15;11(2). Epub 2019 Feb 15.

Department of Social Medicine, School of Public Health, China Medical University, Shenyang 110122, China.

Dietary patterns during pregnancy have been shown to influence the development of gestational diabetes mellitus (GDM). However, evidence from Asian populations is limited and inconsistent. We conducted a prospective cohort study in China to assess the relationship between dietary patterns and GDM. Read More

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http://dx.doi.org/10.3390/nu11020405DOI Listing
February 2019

Clear Cell Carcinoma of the Abdominal Wall as a Rare Complication of General Obstetric and Gynecologic Surgeries: 15 Years of Experience at a Large Academic Institution.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology; National Taiwan University Hospital, Taipei 100, Taiwan.

The objective of this article was to report the clinicopathological characteristics, treatment modalities, and outcomes of patients with clear cell carcinoma (CCC) of the abdominal wall. Medical records of six patients diagnosed with CCC of the abdominal wall between May 2003 and May 2018 at the National Taiwan University Hospital were reviewed. All patients had prior obstetric or gynecologic surgeries. Read More

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http://dx.doi.org/10.3390/ijerph16040552DOI Listing
February 2019

Current Progress in Uterus Transplantation Research in Asia.

J Clin Med 2019 Feb 14;8(2). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.

Uterus transplantation (UTx) is now a possible approach for women with absolute uterine factor infertility to deliver a child, following the first successful delivery by Brännström et al. in Sweden in September 2014. This remarkable achievement attracted major attention worldwide and caused many countries to prepare for UTx, including countries in Asia. Read More

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http://dx.doi.org/10.3390/jcm8020245DOI Listing
February 2019

Adherence and Concordance of Influenza and Pertussis Vaccination Coverage in Pregnant Women in Spain.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Unidad Mixta de Investigación para el Análisis de las Desigualdades en Salud y la Mortalidad FISABIO-UA, Departament of Community Health, Preventive Medicine and Public Health, and Science's History, University of Alicante, Carretera de San Vicente del Raspeig s/n, 03690 Alicante, Spain.

: Pregnant women should receive two vaccines during pregnancy due to maternal-foetal complications and risks as well as the influenza and pertussis vaccinations. The goal was to evaluate vaccination coverage against influenza and pertussis in pregnant women, following midwife professional advice during the pregnancy follow-up; : Prospective cohort study of 1017 pregnancies during the vaccination campaign in 2015⁻2016. To estimate the degree of consistency between the coverage declared by mothers and that registered in the Nominal Vaccination Registry (NVR), we used the Cohen's kappa index (k); : 95. Read More

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http://dx.doi.org/10.3390/ijerph16040543DOI Listing
February 2019

Increasing the Chances of Natural Conception: Opinion Statement from the the Brazilian Federation of Gynecology and Obstetrics Associations Committee on Endocrine Gynecology.

Rev Bras Ginecol Obstet 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medical Sciences, Universidade de Pernambuco, Recife, PE, Brazil.

Considering that myths and misconceptions regarding natural procreation spread rapidly in the era of easy access to information and to social networks, adequate counseling about natural fertility and spontaneous conception should be encouraged in any kind of health assistance. Despite the fact that there is no strong-powered evidence about any of the aspects related to natural fertility, literature on how to increase the chances of a spontaneous pregnancy is available. In the present article, the Brazilian Federation of Gynecology and Obstetrics Associations (FEBRASGO, in the Portuguese acronym) Committee on Endocrine Gynecology provides suggestions to optimize counseling for non-infertile people attempting spontaneous conception. Read More

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http://dx.doi.org/10.1055/s-0039-1677838DOI Listing
February 2019

Cholecystectomy During the Third Trimester of Pregnancy: Proceed or Delay?

J Am Coll Surg 2019 Jan 8. Epub 2019 Jan 8.

Department of Surgery, Massachusetts General Hospital, Boston, MA.

Background: Current guidelines suggest that cholecystectomy during the third trimester of pregnancy is safe for both the women and the fetus. However, no population-based study has examined this issue. The aim of this analysis was to compare the results of cholecystectomy during the third trimester of pregnancy with outcomes in women operated on in the early postpartum period in a large population. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.024DOI Listing
January 2019

Trehalose restores functional autophagy suppressed by high glucose.

Reprod Toxicol 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics, Gynecology & Reproductive Sciences, Baltimore, Maryland, USA; Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA. Electronic address:

Autophagy is required for neurulation, and autophagy activators with minimal toxicity, such as the natural compound trehalose, a nonreducing disaccharide, possess high therapeutic value. To determine whether trehalose directly induces autophagy, FITC-labeled trehalose was used for tracing its presence in autophagosome complexes. Trehalose was as potent as rapamycin and starvation in inducing de novo autophagosome formation and increasing autophagosome flux in GFP-LC3 reporter cells and C17. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.005DOI Listing
February 2019

Role of PCSK9 in PCOS.

Metabolism 2019 Feb 12. Epub 2019 Feb 12.

Department of Physiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, Chengdu, China. Electronic address:

Background: Proprotein convertase subtilisin / kexin type 9 (PCSK9) plays a critical role in the cholesterol metabolism by negatively regulating the low-density lipoprotein receptor (LDLR). Lipid metabolic and ovarian disorders are the common clinical manifestation of polycystic ovary syndrome (PCOS). Here, we intended to elucidate the role of PCSK9 in the pathogenesis of PCOS conducted on a human population in case-control design and animal part in an interventional study. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.02.002DOI Listing
February 2019

Increased the risk of osteoporosis with hysterectomy: A longitudinal follow-up study using a national sample cohort.

Am J Obstet Gynecol 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea. Electronic address:

Background: Premenopausal hysterectomy is associated with a decreased ovarian reserve, follicular atresia, and subsequently reduced long-term estrogen secretion. Therefore, women who undergo hysterectomy will experience greater gradual bone mineral loss than women with an intact uterus and have an increased risk of osteoporosis.

Objective: This study aimed to evaluate the association between hysterectomy without/with bilateral oophorectomy (BO) and the occurrence of osteoporosis using a national sample cohort from South Korea. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.018DOI Listing
February 2019

Induction of Labor at 39 Weeks of Gestation vs. Expectant Management for Low-Risk Nulliparous Women: A Cost-Effectiveness Analysis.

Am J Obstet Gynecol 2019 Feb 12. Epub 2019 Feb 12.

Oregon Health & Science University, Department of Obstetrics and Gynecology. Portland, OR.

Background: A large, recent multicenter trial found that induction of labor at 39 weeks for low-risk nulliparous women was not associated with an increased risk of cesarean delivery or adverse neonatal outcomes.

Objective: We sought to examine the cost-effectiveness and outcomes associated with induction of labor at 39 weeks versus expectant management for low-risk nulliparous women in the United States.

Study Design: A cost-effectiveness model using TreeAge software was designed to compare outcomes in women who were induced at 39 weeks versus expectantly managed. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.017DOI Listing
February 2019

Assessment of optimal insulin administration timing for standard carbohydrates rich meals using continuous glucose monitoring in children with type 1 diabetes-crossover randomized study.

J Diabetes Investig 2019 Feb 15. Epub 2019 Feb 15.

Department of Children's Diabetology, Medical University Of Silesia, Katowice, Poland.

Objective: Assessment of postprandial glucose concentration after carbohydrates rich meals using continuous glucose monitoring in 30 children with type 1 diabetes treated using continuous subcutaneous insulin infusion with a rapid-acting analogs insulin.

Methods: During 3 days, participants administering simple boluses with different delay time between insulin administration and beginning of carbohydrates rich meals consumption (meal №1 containing - 197 kcal, №2 - 247 kcal and meal №3 - 323 kcal; practically not containing protein and fat). In our cross-over randomized study we analyzed: average glucose concentration profiles in 5-minutes intervals, mean glucose at insulin administration, after 120 and 180 minutes, mean and peak glucose, glucose peak time, areas under glucose and glucose increase curves, time period lengths with glucose below 50, 70 mg/dl and over 140, 200 mg/dl. Read More

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http://dx.doi.org/10.1111/jdi.13027DOI Listing
February 2019

Are B Cells Altered in the Decidua of Women with Preterm or Term Labor?

Am J Reprod Immunol 2019 Feb 15:e13102. Epub 2019 Feb 15.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA.

Problem: The immunophenotype of B cells at the maternal-fetal interface (decidua) in labor at term and preterm labor is poorly understood.

Method Of Study: Decidual tissues were obtained from women with preterm or term labor and from non-labor gestational age-matched controls. Immunophenotyping of decidual B cells was performed using multi-color flow cytometry. Read More

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http://dx.doi.org/10.1111/aji.13102DOI Listing
February 2019

Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Common Problem Drugs and How to Prescribe Them.

J Clin Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

The American College of Clinical Pharmacology, Ashburn, VA, USA.

Although the medical profession strives for safe prescribing, most medications are unique challenges even when prescribed by an experienced provider. In this article we discuss the pitfalls associated with drug interactions between commonly used antibiotics and anticoagulants, the complexities associated with the administration of novel reversible anticoagulants, the often-overlooked severe adverse drug reactions from commonly used classes of medications such as corticosteroids, the nuances of managing an acetaminophen overdose, and uncommon yet serious adverse events associated with the use of contraceptive hormone drugs. Read More

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http://dx.doi.org/10.1002/jcph.1389DOI Listing
February 2019