327,073 results match your criteria Obstetrical & Gynecological Survey[Journal]


Profile of Pregnant Women with Gestational Diabetes Mellitus at Increased Risk for Large for Gestational Age Newborns.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Endocrinology Unit of University Hospital, Universidade Federal do Maranhão, São Luís, MA, Brazil.

Objective:  Gestational diabetes mellitus (GDM) is associated with a higher risk of perinatal morbidity and mortality, and its main complication is the occurrence of large for gestational age (LGA) newborns. The present study aims to characterize pregnant women with GDM and to identify factors associated with the occurrence of LGA newborns in this population.

Methods:  A cross-sectional study was performed based on medical records of women whose prenatal care and delivery were performed at the Maternal and Child Unit of the Hospital Universitário of the Universidade Federal do Maranhão, state of Maranhão, Brazil. Read More

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http://dx.doi.org/10.1055/s-0039-1687860DOI Listing

Laparoscopic Box Training with Four Different Modules in a Tertiary Education and Research Hospital, Ankara, Turkey.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Department of Obstetrics and Gynecology, University of Health Sciences, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1055/s-0039-1688411DOI Listing

Molecular aspects of signalling in diabesity.

Mol Aspects Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2019.04.003DOI Listing

The ROC Curve Redefined - Optimizing Sensitivity (and Specificity) to the Lived Reality of Cancer.

Authors:
Susan P Walker

N Engl J Med 2019 Apr;380(17):1594-1595

From the Department of Obstetrics and Gynaecology, University of Melbourne; and Mercy Hospital for Women - both in Melbourne, Australia.

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http://dx.doi.org/10.1056/NEJMp1814951DOI Listing

Inherited risk plus prenatal insult caused malignant dysfunction in mesenteric arteries in adolescent SHR offspring.

PLoS One 2019 24;14(4):e0215994. Epub 2019 Apr 24.

Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China.

Prenatal hypoxia can induce cardiovascular diseases in the offspring. This study determined whether and how prenatal hypoxia may cause malignant hypertension and impaired vascular functions in spontaneous hypertension rat (SHR) offspring at adolescent stage. Pregnant SHR were placed in a hypoxic chamber (11% O2) or normal environment (21% O2) from gestational day 6 until birth. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215994PLOS

Reply to the Letter to the Editor: methodological issues on the clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large-for-gestational-age (LGA) fetuses in non-diabetic pregnancies.

J Perinat Med 2019 Apr 24. Epub 2019 Apr 24.

Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1515/jpm-2019-0110DOI Listing

Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure.

J Hum Lact 2019 Apr 24:890334419843307. Epub 2019 Apr 24.

2 Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

Background: Cyclobenzaprine is a skeletal muscle relaxant primarily used in the treatment of pain. Its use during lactation is a matter of concern as its level of exposure to infants through human milk is still unknown.

Research Aim: The aim of this study was to determine cyclobenzaprine concentrations in the milk samples collected from two lactating mothers. Read More

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http://dx.doi.org/10.1177/0890334419843307DOI Listing

A Review of Deep Infiltrative Colorectal Endometriosis Treated Robotically at a Single Institution.

Int J Med Robot 2019 Apr 24:e2001. Epub 2019 Apr 24.

Department of General Surgery and Colorectal Surgery at the George Washington University Hospital, Washington, DC.

Purpose/background: Using robotic surgery, we report successful resection of deep invasive pelvic endometriosis with a multidisciplinary team of colorectal and gynecologic surgeons.

Methods/interventions: Fifteen cases of robotic assisted endometrial resections for deep invasive endometriosis were performed by a multidisciplinary team between 2013 and 2016.

Results/outcomes: The average total operative time of robotic endometrial extirpation was 342 minutes and the average blood loss was 283 cc. Read More

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http://dx.doi.org/10.1002/rcs.2001DOI Listing

Impact of introduction of non-invasive prenatal testing on uptake of genetic testing in fetuses with central nervous system anomalies.

Prenat Diagn 2019 Apr 24. Epub 2019 Apr 24.

Department of Obstetrics and Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada.

Objective: To evaluate the impact of introduction of non-invasive prenatal testing (NIPT) on the uptake of invasive testing in pregnancies complicated by fetal central nervous system (CNS) anomalies.

Methods: Retrospective review of all singleton pregnancies complicated by fetal CNS anomalies seen at a single tertiary center between 2010 and 2017. Cases who had undergone invasive testing or NIPT prior to the diagnosis of the CNS anomaly were excluded. Read More

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http://dx.doi.org/10.1002/pd.5466DOI Listing

A blueprint to establish a four-bed obstetric critical care unit in the labor ward of a central hospital.

Int J Gynaecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Department of Obstetrics and Gynaecology, Icesi University and Fundacion Valle del Lili, Cali, Colombia.

Patients at risk of organ dysfunction or with established organ dysfunction should be referred to central or tertiary-level hospitals. However, even in central hospitals, intensive care unit (ICU) beds are often unavailable, which may contribute to maternal deaths. One pragmatic solution is to establish obstetric critical care units (OCCUs) in the labor wards of central hospitals; however, specific guidance on how to do this is limited. Read More

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http://dx.doi.org/10.1002/ijgo.12828DOI Listing

The G allele of the rs12050217 polymorphism in the BDKRB1 gene is associated with protection for diabetic retinopathy.

Curr Eye Res 2019 Apr 24. Epub 2019 Apr 24.

c Biochemical Pharmacology Lab, Center for Experimental Research , Hospital de Clínicas de Porto Alegre , Porto Alegre , Rio Grande do Sul , Brazil .

Purpose: The plasma kallikrein kinin system is activated during vascular injury caused by diabetic retinopathy (DR), being involved in hyperpermeability and inflammation. Bradykinin B1 receptor (B1R) is expressed in human retina and its levels are increased in murine models of diabetes. Experimental studies reveal that B1R antagonists ameliorate retinal injury caused by diabetes in rodents. Read More

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http://dx.doi.org/10.1080/02713683.2019.1610178DOI Listing

The Labor Progression Study (LaPS): The use of oxytocin augmentation during labor following Zhang's guideline and the WHO partograph in a cluster randomized trial.

Acta Obstet Gynecol Scand 2019 Apr 24. Epub 2019 Apr 24.

Department of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.

Introduction: This study aims to investigate the use of oxytocin augmentation during labor in nulliparous women following Zhang's guideline or the WHO partograph.

Material And Methods: This is a secondary analysis of a cluster randomized controlled trial in 14 birth care units in Norway, randomly assigned to either the intervention group, which followed Zhang's guideline, or to the control group, which followed the WHO partograph, for labor progression. The participants were nulliparous women who had a singleton full-term fetus in a cephalic presentation and spontaneous onset of labor, denoted as group 1 in the Ten Group Classification System. Read More

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http://dx.doi.org/10.1111/aogs.13629DOI Listing
April 2019
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Fetal and perinatal outcome associated with small cerebellar diameter based on second or third-trimester ultrasonography.

Prenat Diagn 2019 Apr 24. Epub 2019 Apr 24.

Hospices Civils de Lyon, Department of Obstetrics and Gynecology, Université Claude Bernard, Lyon 1, Hôpital Femme Mère Enfant, 59 boulevard Pinel, 69500, Bron-Lyon, France.

Objective: To examine the outcome of pregnancy with fetal transverse cerebellar diameter (TCD) below the 5 percentile based on routine second or third-trimester ultrasonography.

Methods: We retrospectively analyzed the outcomes of 12,344 women according to TCD Z-scores based on systematic second or third-trimester ultrasound examination between 2007 and 2015. Information on major malformations, chromosomal anomalies, intrauterine or neonatal demise, and other abnormal findings were collected. Read More

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http://dx.doi.org/10.1002/pd.5465DOI Listing

Implementing Lean Six Sigma in a Kuwaiti private hospital.

Int J Health Care Qual Assur 2019 Mar;32(2):431-446

Department of Industrial Engineering, The American University of the Middle East , Egaila, Kuwait.

Purpose: The purpose of this paper is to use Lean Six Sigma (LSS) to reduce patient waiting time in a Kuwaiti private hospital obstetrics and gynaecology clinic.

Approach: The define, measure, analyse, improve and control methodology was used. The "define" stage involved identifying patients' needs, system capabilities and project objectives. Read More

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http://dx.doi.org/10.1108/IJHCQA-04-2018-0099DOI Listing

Prevalence of asthma and respiratory symptoms during pregnancy in the middle belt of Nigeria.

J Asthma 2019 Apr 24:1-10. Epub 2019 Apr 24.

a Department of Medicine , University of Ilorin Teaching Hospital , Ilorin , Nigeria.

Background: Information about the burden of asthma during pregnancy in Africa is scarce.

Objectives: To determine the prevalence of asthma and respiratory symptoms in pregnancy in Ilorin, Nigeria.

Methods: This study uses the European Community Respiratory Health Survey (ECRHS) questionnaire and definitions to screen 870 pregnant women attending three hospitals for asthma. Read More

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http://dx.doi.org/10.1080/02770903.2019.1606236DOI Listing

Trends in obstetric policies in cases of failed vacuum extraction in Japan.

J Matern Fetal Neonatal Med 2019 Apr 24:1-11. Epub 2019 Apr 24.

a Department of Obstetrics and Gynecology , Japanese Red Cross Katsushika Maternity Hospital , Tokyo.

Objective: In April 2008, the guidelines for obstetric practice in Japan have made the following recommendations: (1) do not use vacuum extraction (VE) for more than 20 minutes, and consider forceps delivery (FD) or an emergency cesarean section (CS) if necessary (20-minute VE trial rule), and (2) do not try VE more than 5 times, even if VE has been used for less than 20 minutes (5-time VE trial rule). The aims of the present study were to compare the obstetric policies related to failed VE before and after 2008.

Methods: We reviewed the obstetric records of all cases of VE in cases of singleton pregnancy with a neonatal birth weight ≥ 2500 g beyond 37 weeks' gestation at our hospital from April 2002 to March 2014. Read More

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http://dx.doi.org/10.1080/14767058.2019.1611767DOI Listing

Effect of Sperm DNA Fragmentation on Embryo Quality in Normal Responder Women in In Vitro Fertilization and Intracytoplasmic Sperm Injection.

Yonsei Med J 2019 May;60(5):461-466

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: To investigate the associations between sperm DNA fragmentation (SDF) and embryo formation rate in normal responder women to in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI).

Materials And Methods: Fifty-three consecutive, fresh IVF/ICSI cycles performed from 2014 to 2017 were selected. All women were normal responders (4 to 14 mature oocytes were retrieved) and at least one normally fertilized oocyte with two pronuclei was obtained in all cycles. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.5.461DOI Listing

An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer.

Cancer Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Obstetrics and Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, P.R China.

Ovarian cancer is one of the most common female reproductive system malignancies worldwide. Recently, the aberrant long noncoding RNAs (lncRNAs) expression has been identified in multiple cancers. Emerging evidence has highlighted the critical roles of lncRNAs in carcinogenesis and tumor progression, including ovarian cancer. Read More

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http://dx.doi.org/10.1002/cam4.2171DOI Listing

TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.

J Cell Mol Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Neurosurgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.

The pathogenesis of Cushing's disease, which is caused by pituitary corticotroph adenoma, remains to be studied. Secreted angioinhibitory factor thrombospondin-1 (TSP-1) is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is associated with platelet aggregation, angiogenesis and tumorigenesis. We have found that the expression of TSP-1 is significantly lower in human pituitary corticotroph tumours compared with normal adenohypophysis. Read More

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http://dx.doi.org/10.1111/jcmm.14297DOI Listing

Bisphenol A promotes the proliferation of leiomyoma cells by GPR30-EGFR signaling pathway.

J Obstet Gynaecol Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Aim: To study the molecular mechanism of G protein-coupled receptor 30-epidermal growth factor receptor (GPR30-EGFR) signaling pathway on the proliferation of leiomyoma cells exposed with bisphenol A.

Methods: Primary cultures and subcultures of human uterine leiomyoma (UL) cells. The expressions of messenger RNA and proteins of GPR30 and EGFR in 15 leiomyoma tissue specimens and all groups were detected by real-time quantitative polymerase chain reaction assay and Western blot assay. Read More

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http://dx.doi.org/10.1111/jog.13972DOI Listing

Inhibition of aerobic glycolysis enhances the anti-tumor efficacy of Zoptarelin Doxorubicin in triple-negative breast cancer cells.

J Obstet Gynaecol Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Gynecology and Obstetrics, Georg-August-University, Göttingen, Germany.

Aim: A characteristic of cancer cells including triple-negative breast cancers (TNBC) is an increased aerobic glycolysis for ATP production representing a selective therapeutic target. More than 70% of TNBC express gonadotropin-releasing hormone receptors (GnRH-R). These receptors can be used for targeted chemotherapy with cytotoxic GnRH agonists such as Zoptarelin Doxorubicin, in which doxorubicin is covalently linked to [D-Lys ]GnRH. Read More

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http://dx.doi.org/10.1111/jog.13980DOI Listing

Internal podalic version for delivery of high floating head during cesarean section and neonatal outcome.

J Obstet Gynaecol Res 2019 Apr 24. Epub 2019 Apr 24.

Department of Pediatrics and Neonatology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Aim: To evaluate the technique of internal podalic version for delivery of high floating head during cesarean section as an alternative for other methods for its delivery and its effects on neonatal outcome.

Methods: This study used clinical randomized controlled study design. Three groups of patients each group has 50 patients who attended for elective cesarean section and found to have high floating head during operation, Group I: the babies were delivered by internal podalic version. Read More

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http://dx.doi.org/10.1111/jog.13979DOI Listing

Effect of Shoutai Pills on Th1/Th2 Cytokines in Serum and Endometrium of Rats with Stimulated Ovulation.

Curr Med Sci 2019 Apr 23;39(2):285-290. Epub 2019 Apr 23.

Department of Obstetrics and Gynecology, Central Theater General Hospital of Chinese People's Liberation Army, Wuhan, 430070, China.

In our previous study, we found that Shoutai pills could improve the embryo implantation rate as well as the levels of estrogen, progesterone and estrogen receptor in rats with stimulated ovulation. However, the mechanism is not clear. This study was designed to investigate the effect of Shoutai pills on the levels of Th1 and Th2 cytokines in rats with stimulated ovulation and the mechanism. Read More

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http://dx.doi.org/10.1007/s11596-019-2032-4DOI Listing

A Second Dose of GnRHa in Combination with Luteal GnRH Antagonist May Eliminate Ovarian Hyperstimulation Syndrome in Women with ≥30 Follicles Measuring ≥11 mm in Diameter on Trigger Day and/or Pre-trigger Peak Estradiol Exceeding 10 000 pg/mL.

Curr Med Sci 2019 Apr 23;39(2):278-284. Epub 2019 Apr 23.

Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

This observational study included 21 patients at remarkably high risk of ovarian hyperstimulation syndrome (OHSS), characterized by more than 30 follicles measuring ≥11 mm in diameter on trigger day and/or pre-trigger peak estradiol exceeding 10 000 pg/mL, which was also the feature of women with established severe early OHSS followed by gonadotrophin-releasing hormone agonist (GnRHa) trigger and freeze-all policy that previously have been reported. All patients received a second dose of GnRHa 12 h after the first GnRHa trigger combined with administration of GnRH antagonist at 0.25 mg/day for a period of 3 days from the day of oocyte retrieval onwards. Read More

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http://dx.doi.org/10.1007/s11596-019-2031-5DOI Listing

Placental Origins of Preeclampsia: Potential Therapeutic Targets.

Curr Med Sci 2019 Apr 23;39(2):190-195. Epub 2019 Apr 23.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 4300030, China.

Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity and mortality in obstetrics worldwide. No effective treatments to reduce its incidence and severity in clinical practice are currently available. A variety of hypotheses have been generated aiming to explain the origins of PE, notably being the genetic predispositions and placental dysfunction. Read More

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http://dx.doi.org/10.1007/s11596-019-2018-2DOI Listing

Para-aortic Lymphadenectomy for Gynecologic Cancers: Introducing the "Trans-Retro-Peritoneal (TRP) Single-Port Access".

Ann Surg Oncol 2019 Apr 23. Epub 2019 Apr 23.

Department of Gynaecology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Background: In gynecological surgery to date, two distinct types of endoscopic accesses have been used to perform para-aortic lymphadenectomies: transperitoneal and extraperitoneal, each with advantages and disadvantages. We propose to develop a new mini-invasive access to perform an endoscopic extraperitoneal para-aortic lymphadenectomy via a single-port umbilical device that, to our knowledge, has never been described.

Methods: This innovative approach combines both an extraperitoneal and intraperitoneal procedure via the same umbilical incision using one single trocar. Read More

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http://dx.doi.org/10.1245/s10434-019-07379-8DOI Listing

VO Max Improvement of 96% in a Non-Elite Recreational Athlete over 24 Months.

Surg J (N Y) 2019 Jan 22;5(1):e25-e27. Epub 2019 Apr 22.

Department of Orthopedic Surgery, Mount Sinai School of Medicine, New York, New York.

VO max is a measure of athletic performance and is generally considered an excellent health parameter for athletic performance testing. Various methods are used to generate such a result generally using a treadmill or cycle ergometer. Improvements have been shown through training. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1688438
Publisher Site
http://dx.doi.org/10.1055/s-0039-1688438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476626PMC
January 2019
1 Read

Diagnostic Value of Cytology in Detecting Endometrial Hyperplasia and Endometrial and Ovarian Cancers in Patients Undergoing Hysterectomy or Salpingo-Oophorectomy.

Adv Biomed Res 2019 20;8:20. Epub 2019 Mar 20.

Department of Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan Iran.

Background: Ovarian cancer (OC) is one of the most common cancers among women in the world. This study aimed to compare the results of endometrial and endocervical cytology with the ultimate outcome of the uterus, ovary, and fallopian tube (derived from hysterectomy or salpingo-oophorectomy) in diagnosing endometrial hyperplasia, endometrial, and OC.

Materials And Methods: This cross-sectional study was conducted on 30 women with endometrial hyperplasia, 90 cases of endometrial cancer, 30 cases of OC, and 30 normal controls undergoing hysterectomy or salpingo-oophorectomy referring to Al-Zahra and Shahid Beheshti Hospitals in 2015-2017. Read More

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http://dx.doi.org/10.4103/abr.abr_191_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446583PMC

Heart Failure Hospitalization with DPP-4 Inhibitors: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):128-133

Department of Gynecology and Obstetrics, G.D Hospital and Diabetes Institute, Kolkata, West Bengal, India.

Background: Heart failure hospitalization (hHF) with dipeptyl-dipeptidase-4 inhibitors (DPP-4Is) remains at the center stage since the publication of Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus - Thrombolysis in Myocardial Infarction (SAVOR-TIMI) in 2013 showing significant increase with saxagliptin, compared to placebo. This outcome led to additional label of hHF to both saxagliptin and alogliptin in April 2016 and eventual labelling of hHF to all the four approved DPP-4Is in United States in August 2017, by US Food Drug Administration. To note, neither Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS), nor Cardiovascular and Renal Microvascular Outcome Study with Linagliptin (CARMELINA), showed any signals of hHF with these two agents. Read More

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http://www.ijem.in/text.asp?2019/23/1/128/254459
Publisher Site
http://dx.doi.org/10.4103/ijem.IJEM_613_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446681PMC

Abdominal Wall Endometriosis: A Case Report.

Cureus 2019 Feb 13;11(2):e4061. Epub 2019 Feb 13.

General Surgery, Saint George Hospital/ Lebanese University, Beirut, LBN.

Abdominal wall endometriosis is a rare condition that occurs after a cesarean section or pelvic surgery and it has an incidence of 0.03%-1.5% in women with previous cesarean delivery. Read More

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http://dx.doi.org/10.7759/cureus.4061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464279PMC
February 2019

A Case of Dubin-Johnson Syndrome in Pregnancy.

Cureus 2019 Feb 11;11(2):e4048. Epub 2019 Feb 11.

Obstetrics & Gynecology, Maulana Azad Medical College, New Delhi, IND.

Dubin-Johnson syndrome is an autosomal recessive condition characterized by recurrent episodes of jaundice and conjugated hyperbilirubinemia. It exacerbates during pregnancy and needs to be differentiated from other causes of jaundice. A 30-year-old patient presented to us with jaundice in her fourth pregnancy. Read More

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http://dx.doi.org/10.7759/cureus.4048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464460PMC
February 2019

Do health care providers trust product monograph information regarding use of vaccines in pregnancy? A qualitative study.

Can Commun Dis Rep 2018 Jun 7;44(6):134-138. Epub 2018 Jun 7.

Department of Pediatrics, Dalhousie University, Halifax, NS.

Background: Influenza immunization is recommended in pregnancy to prevent severe infections in pregnant women and newborns, yet vaccine uptake remains low. Studies suggest that cautionary language in vaccine product monographs regarding safety and use in pregnancy affects health care providers' perceptions of vaccine safety and how they counsel pregnant women.

Objective: To conduct a qualitative analysis of health care provider perceptions of the safety of inactivated influenza vaccines and their recommendations for use in pregnancy based on product monograph language statements. Read More

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Successful Delivery after Abdominal Radical Trachelectomy, Using Transabdominal Cerclage in Early Pregnancy.

Acta Med Okayama 2019 Apr;73(2):173-176

Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan.

Radical trachelectomy (RT) is a fertility-sparing surgery for cervical cancer. Postoperative pregnancies have a high risk of abortion and prematurity. To prevent this, a procedure involving transabdominal cerclage (TAC) was devised for shortened cervical canals post-RT. Read More

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http://dx.doi.org/10.18926/AMO/56653DOI Listing
April 2019
1 Read

The serum level of irisin, but not asprosin, is abnormal in polycystic ovary syndrome patients.

Sci Rep 2019 Apr 23;9(1):6447. Epub 2019 Apr 23.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, 5 Fu-Shin Street, Kweishan, Taoyuan, Taiwan.

Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, oligo- or anovulation, and/or polycystic ovary. It frequently presents with dyslipidemia and insulin resistance. Recent studies have shown that the white adipose tissue-derived asprosin is elevated in humans with insulin resistance. Read More

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http://dx.doi.org/10.1038/s41598-019-42061-9DOI Listing

SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles.

Sci Rep 2019 Apr 24;9(1):6513. Epub 2019 Apr 24.

Academic Unit of Reproductive and Developmental Medicine, Department of Oncology and Metabolism, University of Sheffield, Sheffield, S10 2SF, United Kingdom.

Primordial follicles, consisting of granulosa cell (GC)-enveloped oocytes are maintained in a state of developmental arrest until activated to grow. The mechanism that operates to maintain this arrested state in GCs is currently unknown. Here, we show the TGFβ-activated transcription factor SMAD3 is expressed in primordial GC nuclei alongside the cell cycle proteins, cyclin D2 (CCND2) and P27. Read More

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http://dx.doi.org/10.1038/s41598-019-42878-4DOI Listing

Genome-wide DNA methylation analysis in obese women predicts an epigenetic signature for future endometrial cancer.

Sci Rep 2019 Apr 23;9(1):6469. Epub 2019 Apr 23.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Toho University, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.

Aberrant DNA methylation is associated with the oncogenesis of a variety of human cancers, including endometrial cancer (EC), the seventh most common cancer among women. Obesity is known to be a high-risk factor for EC; however, whether obesity influences DNA methylation in the presymptomatic uterus and if this influences EC development remain unclear. Here, we performed genome-wide DNA methylation analysis of isolated endometrial epithelial cells obtained from obese presymptomatic participants. Read More

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http://dx.doi.org/10.1038/s41598-019-42840-4DOI Listing

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Authors:
Leanne K Küpers Claire Monnereau Gemma C Sharp Paul Yousefi Lucas A Salas Akram Ghantous Christian M Page Sarah E Reese Allen J Wilcox Darina Czamara Anne P Starling Alexei Novoloaca Samantha Lent Ritu Roy Cathrine Hoyo Carrie V Breton Catherine Allard Allan C Just Kelly M Bakulski John W Holloway Todd M Everson Cheng-Jian Xu Rae-Chi Huang Diana A van der Plaat Matthias Wielscher Simon Kebede Merid Vilhelmina Ullemar Faisal I Rezwan Jari Lahti Jenny van Dongen Sabine A S Langie Tom G Richardson Maria C Magnus Ellen A Nohr Zongli Xu Liesbeth Duijts Shanshan Zhao Weiming Zhang Michelle Plusquin Dawn L DeMeo Olivia Solomon Joosje H Heimovaara Dereje D Jima Lu Gao Mariona Bustamante Patrice Perron Robert O Wright Irva Hertz-Picciotto Hongmei Zhang Margaret R Karagas Ulrike Gehring Carmen J Marsit Lawrence J Beilin Judith M Vonk Marjo-Riitta Jarvelin Anna Bergström Anne K Örtqvist Susan Ewart Pia M Villa Sophie E Moore Gonneke Willemsen Arnout R L Standaert Siri E Håberg Thorkild I A Sørensen Jack A Taylor Katri Räikkönen Ivana V Yang Katerina Kechris Tim S Nawrot Matt J Silver Yun Yun Gong Lorenzo Richiardi Manolis Kogevinas Augusto A Litonjua Brenda Eskenazi Karen Huen Hamdi Mbarek Rachel L Maguire Terence Dwyer Martine Vrijheid Luigi Bouchard Andrea A Baccarelli Lisa A Croen Wilfried Karmaus Denise Anderson Maaike de Vries Sylvain Sebert Juha Kere Robert Karlsson Syed Hasan Arshad Esa Hämäläinen Michael N Routledge Dorret I Boomsma Andrew P Feinberg Craig J Newschaffer Eva Govarts Matthieu Moisse M Daniele Fallin Erik Melén Andrew M Prentice Eero Kajantie Catarina Almqvist Emily Oken Dana Dabelea H Marike Boezen Phillip E Melton Rosalind J Wright Gerard H Koppelman Letizia Trevisi Marie-France Hivert Jordi Sunyer Monica C Munthe-Kaas Susan K Murphy Eva Corpeleijn Joseph Wiemels Nina Holland Zdenko Herceg Elisabeth B Binder George Davey Smith Vincent W V Jaddoe Rolv T Lie Wenche Nystad Stephanie J London Debbie A Lawlor Caroline L Relton Harold Snieder Janine F Felix

Nat Commun 2019 Apr 23;10(1):1893. Epub 2019 Apr 23.

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P < 1.06 x 10). Read More

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http://dx.doi.org/10.1038/s41467-019-09671-3DOI Listing

Social model of disability must be a core competency in medical education.

Authors:
Jeff Nisker

CMAJ 2019 Apr;191(16):E454

Scientist, Division of Maternal, Fetal & Newborn Health, Children's Health Research Institute; professor, Departments of Obstetrics & Gynaecology and Oncology, Schulich School of Medicine & Dentistry, Western University.

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http://dx.doi.org/10.1503/cmaj.71861DOI Listing

Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin.

Mol Cancer Ther 2019 Apr 23. Epub 2019 Apr 23.

Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University

Tissue transglutaminase (TG2) is a multi-functional protein, with enzymatic, GTP-ase and scaffold properties. TG2 interacts with fibronectin (FN) through its N-terminus domain, stabilizing integrin complexes, which regulate cell adhesion to the matrix. Through this mechanism, TG2 participates in key steps involved in metastasis in ovarian and other cancers. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1148DOI Listing

Predictive value of HPV testing in self-collected and clinician-collected samples compared with cytology in detecting high-grade cervical lesions.

Cancer Epidemiol Biomarkers Prev 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, McGill University.

Background: Self-sampling has become an attractive proposition now that HPV primary testing is being incorporated into cervical cancer screening programs worldwide. We compared predictive values of HPV testing based on self- and physician- collected samples, and cytology, in detecting high-grade cervical intraepithelial neoplasia (CIN).

Methods: The Cervical And Self-Sample In Screening (CASSIS) study enrolled 1217 women aged 16-70 years prior to scheduled colposcopies. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1338DOI Listing

Does being performed by urologist or gynecologist affect the outcomes of women who have had sacrocolpopexy?

Eur J Obstet Gynecol Reprod Biol 2019 Apr 17;237:64-67. Epub 2019 Apr 17.

Department of Urology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Turkey.

Objective: To compare the outcomes of women who underwent abdominal sacrocolpopexy (ASC) by urologist and gynecologist.

Study Design: A total of 61 women underwent transabdominal sacrocolpopexy, with 31 by a urologist (Group 1) and 30 by a gynecologist (Group 2). The patients were presented with symptomatic pelvic organ prolapse (POP). Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.021DOI Listing

Increased expression of YAP is associated with decreased cell autophagy in the eutopic endometrial stromal cells of endometriosis.

Mol Cell Endocrinol 2019 Apr 20. Epub 2019 Apr 20.

Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China. Electronic address:

Basic research has shown that signal pathways play significant roles in the development and progression of endometriosis (EMS). We first reported that the Hippo-YAP (Yes-associated protein) pathway promotes cell proliferation and anti-apoptosis in endometrial stromal cells (ESCs) of EMS. Cell autophagy has been found to be involved in the endometrial regulation and the pathophysiology of EMS. Read More

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http://dx.doi.org/10.1016/j.mce.2019.04.012DOI Listing

Seroprevalence and factors associated with Toxoplasma gondii-, Neospora caninum- and Coxiella burnetii-infections in dairy goat flocks from Costa Rica.

Vet Parasitol Reg Stud Reports 2018 Dec 19;14:79-84. Epub 2018 Sep 19.

Programa de Investigación en Medicina Poblacional, Escuela de Medicina Veterinaria, Universidad Nacional (UNA), P.O. Box 86-3000, Heredia, Costa Rica.

A total of 391 goats from 13 dairy flocks from all Costa Rican regions were analyzed for Toxoplasma gondii-, Neospora caninum- and Coxiella burnetii-related seroprevalence by enzyme-linked immunosorbent assays (ELISA). Additionally, a risk factor analysis for these parasitic infections was performed based on a questionnaire considering several environmental and housing/management factors. A total of 62. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24059390183009
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http://dx.doi.org/10.1016/j.vprsr.2018.09.006DOI Listing
December 2018
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Reply to: Introduction of a dedicated team increases the success rate of external cephalic version: A prospective cohort study.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Obstetrics and Gynecology, Hadassah University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.017DOI Listing

Adjuvant bisphosphonates or RANK-ligand inhibitors for patients with breast cancer and bone metastases: A systematic review and network meta-analysis.

Crit Rev Oncol Hematol 2019 May 19;137:1-8. Epub 2019 Feb 19.

Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Electronic address:

Bone-modifying agents like bisphosphonates and receptor activator of nuclear factor kappaβ ligand (RANK-L) inhibitors are used as supportive treatments in breast cancer patients with bone metastases to prevent skeletal-related events (SREs). Due to missing head-to-head comparisons, a network meta-analysis was performed to provide a hierarchy of these therapeutic options. Through a systematic literature search, 21 randomized controlled trials (RCTs) that fulfilled the inclusion criteria were identified. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2019.02.004DOI Listing

Sociodemographic inequities in cervical cancer screening, treatment and care amongst women aged at least 25 years: evidence from surveys in Harare, Zimbabwe.

BMC Public Health 2019 Apr 24;19(1):428. Epub 2019 Apr 24.

Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Background: Cervical cancer is the most commonly diagnosed cancer among women in Zimbabwe; however; access to screening and treatment services remain challenged. The objective of this study was to investigate socio-demographic inequities in cervical cancer screening and utilization of treatment among women in Harare, Zimbabwe.

Methods: Two cross sectional surveys were conducted in Harare with a total sample of 277 women aged at least 25 years. Read More

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http://dx.doi.org/10.1186/s12889-019-6749-6DOI Listing

Prenatal diagnosis of congenital megalourethra with imperforate anus.

BMC Pediatr 2019 Apr 23;19(1):123. Epub 2019 Apr 23.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Republic of China.

Background: Congenital megalourethra is a rare prenatal finding while prenatal diagnosis of imperforate anus poses high challenge. This is the first prenatally ultrasound diagnosed case which had congenital megalourethra and imperforate anus. This case demonstrated the possibility of using the prenatal imaging findings to evaluate the postnatal prognostic outcomes in multi-organ anomalies. Read More

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http://dx.doi.org/10.1186/s12887-019-1510-yDOI Listing

Anthropometric measurements can identify small for gestational age newborns: a cohort study in rural Tanzania.

BMC Pediatr 2019 Apr 23;19(1):120. Epub 2019 Apr 23.

Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3B, Building 07-11-56, 2200, Copenhagen, Denmark.

Background: Small-for-gestational-age (SGA) is associated with increased neonatal mortality and morbidity. In low and middle income countries an accurate gestational age is often not known, making the identification of SGA newborns difficult. Measuring foot length, chest circumference and mid upper arm circumference (MUAC) of the newborn have previously been shown to be reasonable methods for detecting low birth weight (< 2500 g) and prematurity (gestational age <  37 weeks). Read More

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http://dx.doi.org/10.1186/s12887-019-1500-0DOI Listing

Dexmedetomidine improves cognition after carotid endarterectomy by inhibiting cerebral inflammation and enhancing brain-derived neurotrophic factor expression.

J Int Med Res 2019 Apr 24:300060519843738. Epub 2019 Apr 24.

1 Department of Anesthesiology, Northern Jiangsu People's Hospital, Yangzhou City, Jiangsu Province, China.

Objectives: Carotid endarterectomy (CEA) is efficient in preventing stroke for patients with significant carotid stenosis, but results in mild cognitive dysfunction. Dexmedetomidine is neuroprotective in stroke models. We hypothesized that dexmedetomidine may improve cognition after CEA. Read More

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http://dx.doi.org/10.1177/0300060519843738DOI Listing