20,352 results match your criteria Obsessive-Compulsive Disorder


A Review of the Current Treatment of Tourette Syndrome.

J Pediatr Pharmacol Ther 2020 ;25(5):401-412

Tourette syndrome is a hyperkinetic movement disorder that presents before age 18 years and involves motor and phonic tics that may present with a wide range of severity. The severity and presentation of tics in an individual may fluctuate over time. Tourette syndrome may affect social relationships and school attendance, and may result in depression. Read More

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http://dx.doi.org/10.5863/1551-6776-25.5.401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337131PMC
January 2020

The effects of acute serotonin challenge on executive planning in patients with obsessive-compulsive disorder (OCD), their first-degree relatives, and healthy controls.

Psychopharmacology (Berl) 2020 Jul 8. Epub 2020 Jul 8.

SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

Rationale: Obsessive-compulsive disorder (OCD) is characterized by executive function impairment and by clinical responsivity to selective serotonin reuptake inhibitors (SSRIs). Executive planning deficits constitute a candidate endophenotype for OCD. It is not known whether this endophenotype is responsive to acute serotonin manipulation. Read More

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http://dx.doi.org/10.1007/s00213-020-05597-7DOI Listing

The role of reassurance seeking in obsessive compulsive disorder: the associations between reassurance seeking, dysfunctional beliefs, negative emotions, and obsessive- compulsive symptoms.

BMC Psychiatry 2020 Jul 7;20(1):356. Epub 2020 Jul 7.

Department of Psychology, Ankara Hacı Bayram Veli University, Emniyet Mahallesi Abant 1 Cad. No:10/2D Yenimahalle, Ankara, Turkey.

Background: This study investigates the association of reassurance seeking with obsessive compulsive (OC) symptoms, dysfunctional beliefs, and negative emotions.

Methods: Reassurance Seeking Questionnaire, Obsessive-Compulsive Inventory, Obsessive Beliefs Questionnaire, Trait Anger Expression Inventory, and Guilt Inventory were applied to 53 obsessive compulsive disorder (OCD) patients and 591 non-clinical participants.

Results: The results showed that the severity of the OC symptoms significantly predicted the carefulness of OCD patients during reassurance seeking, indicating increased carefulness during reassurance seeking as the severity of OC symptoms increased. Read More

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http://dx.doi.org/10.1186/s12888-020-02766-yDOI Listing

Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis.

Nutrients 2020 Jul 3;12(7). Epub 2020 Jul 3.

Unit for Nutrition Research, Faculty of Food and Nutritional Sciences, University of Iceland, 101 Reykjavik, Iceland.

Worldwide, up to 20% of children and adolescents experience mental disorders, which are the leading cause of disability in young people. Research shows that serum zonulin levels are associated with increased intestinal permeability (IP), affecting neural, hormonal, and immunological pathways. This systematic review and meta-analysis aimed to summarize evidence from observational studies on IP in children diagnosed with mental disorders. Read More

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http://dx.doi.org/10.3390/nu12071982DOI Listing

A brief demonstration of frontostriatal connectivity in OCD patients with intracranial electrodes.

Neuroimage 2020 Jul 4:117138. Epub 2020 Jul 4.

University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, University Hospital Cologne , Cologne, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, Johanniter Hospital Oberhausen, Oberhausen, Germany.

Closed-loop neuromodulation is presumed to be the logical evolution for improving the effectiveness of deep brain stimulation (DBS) treatment protocols [1]. Identifying symptom-relevant biomarkers that provide meaningful feedback to stimulator devices is an important initial step in this direction. This report demonstrates a technique for assaying neural circuitry hypothesized to contribute to OCD and DBS treatment outcomes. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117138DOI Listing

Pharmacotherapy for trichotillomania in adults.

Expert Opin Pharmacother 2020 Jul 7:1-12. Epub 2020 Jul 7.

Parkwood Institute , London, Canada.

Introduction: Currently conceptualized as an obsessive compulsive and related disorder, trichotillomania, or hair-pulling disorder, is a common illness that causes significant distress or functional impairments in various life domains. Most individuals with trichotillomania also have other comorbid diagnoses. Treating trichotillomania with pharmacotherapy is complicated since there are currently no FDA-approved drugs for its treatment. Read More

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http://dx.doi.org/10.1080/14656566.2020.1761324DOI Listing

Primary headache in childhood associated with psychiatric disturbances: an update.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6893-6898

Department Clinical and Experimental Medicine, Child and Adolescent Neuropsychiatry, University of Catania, Catania, Italy.

Objective: Primary headache disorders in children are one of the most prominent topics in the pediatric neurology literature. However, there are many unsolved aspects, including the conditions associated with migraine. The present study aims to report on the frequency of behavioral comorbidities in the setting of primary headache in childhood. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21680DOI Listing

Reduced DNA methylation of the oxytocin receptor gene is associated with obsessive-compulsive disorder.

Clin Epigenetics 2020 Jul 6;12(1):101. Epub 2020 Jul 6.

Department of Psychiatry, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: Oxytocin is an important neuromodulator involved in cognition and socio-emotional processing that exerts its central activities via oxytocin receptors. Epigenetic alterations in the oxytocin receptor gene (OXTR) may be a molecular mechanism in the pathogenesis of obsessive-compulsive disorder (OCD). This study investigated the association between OXTR DNA methylation and the OCD status of a Korean population. Read More

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http://dx.doi.org/10.1186/s13148-020-00890-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336407PMC

Metacognitive Training for Obsessive-Compulsive Disorder: a study protocol for a randomized controlled trial.

BMC Psychiatry 2020 Jul 6;20(1):350. Epub 2020 Jul 6.

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Background: A high number of patients with obsessive-compulsive disorder (OCD) do not receive cognitive-behavioral therapy with exposure and response prevention, which is the most effective treatment for OCD. Therefore, Metacognitive Training for OCD (MCT-OCD) was developed, which is a structured group therapy aiming at the modification of dysfunctional (meta-)cognitive biases, beliefs and coping styles. It can be administered by less trained personnel, thus may reach a higher number of patients. Read More

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http://dx.doi.org/10.1186/s12888-020-02648-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336399PMC

Neurodynamics of Patients during a Dolphin-Assisted Therapy by Means of a Fractal Intraneural Analysis.

Brain Sci 2020 Jun 25;10(6). Epub 2020 Jun 25.

Escuela Superior de Ingeniería Mecánica y Eléctrica, Instituto Politécnico Nacional, 07340 Ciudad de México, Mexico.

The recent proliferation of sensor technology applications in therapies for children's disabilities to promote positive behavior among such children has produced optimistic results in developing a variety of skills and abilities in them. Dolphin-Assisted Therapy (DAT) has also become a topic of public and research interest for these disorders' intervention and treatment. This work exposes the development of a system that controls brain-computer interaction when a patient with different abilities undergoes a DAT. Read More

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http://dx.doi.org/10.3390/brainsci10060403DOI Listing

A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder.

Nat Commun 2020 Jul 3;11(1):3364. Epub 2020 Jul 3.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for Neurology, Charitéplatz 1, 10117 Berlin, Germany.

Multiple surgical targets for treating obsessive-compulsive disorder with deep brain stimulation (DBS) have been proposed. However, different targets may modulate the same neural network responsible for clinical improvement. We analyzed data from four cohorts of patients (N = 50) that underwent DBS to the anterior limb of the internal capsule (ALIC), the nucleus accumbens or the subthalamic nucleus (STN). Read More

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http://dx.doi.org/10.1038/s41467-020-16734-3DOI Listing
July 2020
10.742 Impact Factor

Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures.

Commun Biol 2020 Jul 3;3(1):338. Epub 2020 Jul 3.

Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden (NBIS), Science for Life Laboratory, Uppsala University, SE-752 37, Uppsala, Sweden.

The subthalamic nucleus (STN) is crucial for normal motor, limbic and associative function. STN dysregulation is correlated with several brain disorders, including Parkinson's disease and obsessive compulsive disorder (OCD), for which high-frequency stimulation of the STN is increasing as therapy. However, clinical progress is hampered by poor knowledge of the anatomical-functional organization of the STN. Read More

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http://dx.doi.org/10.1038/s42003-020-1028-8DOI Listing

Prolonged avoidance training exacerbates OCD-like behaviors in a rodent model.

Transl Psychiatry 2020 Jul 3;10(1):212. Epub 2020 Jul 3.

Departments of Psychiatry and Anatomy & Neurobiology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, 00936, USA.

Obsessive-compulsive disorder (OCD) is characterized by compulsive behaviors that often resemble avoidance of perceived danger. OCD can be treated with exposure-with-response prevention (ERP) therapy in which patients are exposed to triggers but are encouraged to refrain from compulsions, to extinguish compulsive responses. The compulsions of OCD are strengthened by many repeated exposures to triggers, but little is known about the effects of extended repetition of avoidance behaviors on extinction. Read More

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http://dx.doi.org/10.1038/s41398-020-00892-5DOI Listing

When Science Challenges Our Long-Held Assumptions About the Robustness of Evidence for Standard of Care.

J Am Acad Child Adolesc Psychiatry 2020 Jul 25;59(7):792-793. Epub 2020 Jun 25.

Massachusetts General Hospital, Harvard Medical School, Boston.

In this issue of the Journal, we publish two letters pertaining to the article "Systematic Review and Meta-analysis: Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder in Children and Adolescents" by Uhre et al. Their protocol employed the Cochrane Handbook for Systematic Reviews of Interventions to evaluate risk of bias (selection, performance, detection, attrition, and reporting biases) in the included 25 trials, contacting trial authors to obtain missing data where possible. They controlled for random errors owing to sparse data or multiple testing using Trial Sequential Analysis and evaluated the certainty of the evidence using the Grading of Recommendations Assessment Development and Evaluation approach. Read More

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http://dx.doi.org/10.1016/j.jaac.2020.05.003DOI Listing

Dr. Uhre et al. Reply.

J Am Acad Child Adolesc Psychiatry 2020 Jul 25;59(7):787-791. Epub 2020 Jun 25.

Child and Adolescent Mental Health Centre, Capital Region, Denmark; University of Copenhagen, Denmark.

In a recent letter to the editor, a group of clinician-researchers posit that the conclusions in our published systematic review on cognitive-behavioral therapy (CBT) for pediatric obsessive-compulsive disorder (OCD) are based on inappropriate methodology. In this reply, we address the concerns expressed by Storch et al.. Read More

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http://dx.doi.org/10.1016/j.jaac.2020.04.013DOI Listing
July 2020
7.260 Impact Factor

Little Doubt That CBT Works for Pediatric OCD.

J Am Acad Child Adolesc Psychiatry 2020 Jul 25;59(7):785-787. Epub 2020 Jun 25.

Baylor College of Medicine, Houston, Texas.

We write with great concern in response to the recent systematic review and meta-analysis of cognitive-behavioral therapy (CBT) in pediatric obsessive-compulsive disorder (OCD) by Uhre et al. Although the authors' results consistently support the clinical efficacy of CBT for pediatric OCD, we expect that, much like ourselves, readers will be confused by the discordant and inappropriate conclusions that they put forward. These conclusions stem from the authors' application and interpretation of their particular qualitative methods, which could lead important stakeholders (eg, parents, patients, clinicians, and payers) to wrongly discount clear evidence for what is known to be the best evidence-based therapy for pediatric OCD. Read More

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http://dx.doi.org/10.1016/j.jaac.2020.01.026DOI Listing

Effects of long-term growth hormone therapy in a girl with Floating-Harbor syndrome.

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):126-131. Epub 2020 Jun 30.

1 Department of Pediatrics, Inje University Busan Paik Hospital, Busan, Korea.

Floating-Harbor syndrome is a rare autosomal dominant disorder that presents with short stature, facial dysmorphism, significantly delayed bone age, skeletal abnormalities, speech and language problems, and intellectual disabilities. Although short stature is one of the main clinical manifestations, use of growth hormone therapy in Floating-Harbor syndrome patients has been limited. Only a few reports have investigated the response to growth hormone therapy with regard to final adult height. Read More

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http://dx.doi.org/10.6065/apem.1938144.072DOI Listing

A Systematic Review of Deep Brain Stimulation Targets for Obsessive Compulsive Disorder.

Neurosurgery 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurosurgery, Albany Medical College, Albany, New York.

Background: Obsessive compulsive disorder (OCD) is a complex neuropsychiatric disease characterized by obsessions and compulsions. Deep brain stimulation (DBS) has demonstrated efficacy in improving symptoms in medically refractory patients. Multiple targets have been investigated. Read More

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http://dx.doi.org/10.1093/neuros/nyaa249DOI Listing

Serum Lipids among Drug Naïve or Drug-Free Patients with Obsessive Compulsive Disorder and their Association with Impulsivity: A Comparative Study.

Indian J Psychol Med 2020 May-Jun;42(3):281-289. Epub 2020 Apr 25.

Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, India.

Background: The derangement of serum lipids is well documented in psychiatric disorders like schizophrenia, mania, and depression but not in obsessive compulsive disorder (OCD), where it has been inadequately examined. Also, serum lipid abnormalities are increasingly found in "impulsivity," an important sub-construct of OCD. Our study aimed to examine serum lipid profile among patients with OCD and its association with clinical profile and impulsivity among them. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_299_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320738PMC

Clinical Profile of Tic Disorders in Children and Adolescents from a Tertiary Care Center in India.

Indian J Psychol Med 2020 May-Jun;42(3):262-267. Epub 2020 Apr 25.

Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Background: Tic disorders (TDs) are common neurodevelopmental disorders in children and adolescents. To date, there is very scant literature on TDs in children and adolescents in the Indian setting.

Aim: The objectives of this study were to characterize the clinical profile, including comorbidities and pattern of medication use in the treatment of TDs, in children and adolescents. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_324_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320724PMC

Clinical applications of neurochemical and electrophysiological measurements for closed-loop neurostimulation.

Neurosurg Focus 2020 Jul;49(1):E6

1Department of Neurologic Surgery.

The development of closed-loop deep brain stimulation (DBS) systems represents a significant opportunity for innovation in the clinical application of neurostimulation therapies. Despite the highly dynamic nature of neurological diseases, open-loop DBS applications are incapable of modifying parameters in real time to react to fluctuations in disease states. Thus, current practice for the designation of stimulation parameters, such as duration, amplitude, and pulse frequency, is an algorithmic process. Read More

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http://dx.doi.org/10.3171/2020.4.FOCUS20167DOI Listing

Author Correction: Serotonin transporter binding is increased in Tourette syndrome with Obsessive Compulsive Disorder.

Sci Rep 2020 Jul 1;10(1):11092. Epub 2020 Jul 1.

Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41598-020-68278-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326929PMC

Clinical Aspects of Premonitory Urges in Patients with Tourette's Disorder.

Soa Chongsonyon Chongsin Uihak 2019 Mar;30(2):50-56

Department of Psychiatry, College of Medicine, Chonbuk National University, Jeonju, Korea.

Most patients with Tourette's disorder experience an uncomfortable sensory phenomenon called the premonitory urge immediately before experiencing tics. It has been suggested that premonitory urges are associated with comorbidities such as obsessive compulsive disorder, anxiety disorders, and attention-deficit/hyperactivity disorder, although these associations have been inconsistent. Most patients experience tics as a result of the premonitory urges, and after the tics occur, most patients report that the premonitory urges are temporarily relieved. Read More

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http://dx.doi.org/10.5765/jkacap.180025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289498PMC

Women Are at Greater Risk of OCD Than Men: A Meta-Analytic Review of OCD Prevalence Worldwide.

J Clin Psychiatry 2020 Jun 23;81(4). Epub 2020 Jun 23.

Department of Psychology, Memorial University of Newfoundland, St John's, Newfoundland, Canada.

Objective: To estimate the worldwide prevalence of obsessive-compulsive disorder (OCD), examine whether women are at greater risk than men, and explore other potential moderators of OCD prevalence to explain variability in community-based epidemiologic studies.

Data Sources: An electronic search of PsycINFO and PubMed was conducted until January 2017, without date or language restrictions, using the keywords OCD, epidemiology, and prevalence. The search was supplemented by articles referenced in the obtained sources and relevant reviews. Read More

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http://dx.doi.org/10.4088/JCP.19r13085DOI Listing

Retrospective Analysis of Studies Examining Sensory Processing Preferences in People With a Psychiatric Condition.

Am J Occup Ther 2020 Jul/Aug;74(4):7404205130p1-7404205130p11

Megan Steuter, MA, OTR/L, is Occupational Therapist, HonorHealth, Scottsdale, AZ.

Importance: When occupational therapists understand sensory processing preferences, they can create environments that promote participation.

Objective: To determine the sensory processing preferences of people with a psychiatric condition as measured by the Adolescent/Adult Sensory Profile (A/ASP).

Data Sources: PubMed, PsycINFO, ERIC, CINAHL, and OTseeker were searched from 2002 through January 2018. Read More

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http://dx.doi.org/10.5014/ajot.2020.038463DOI Listing

Clinical features of scrupulosity: Associated symptoms and comorbidity.

J Clin Psychol 2020 Jun 30. Epub 2020 Jun 30.

Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Objective: Scrupulosity is a manifestation of obsessive-compulsive disorder (OCD) characterized by religious or moral core fears. Clinicians often struggle to treat scrupulosity, which may be associated with several features known to predict poor treatment outcome. The purpose of this study was to examine these features in participants with scrupulous OCD, contamination OCD, and healthy controls. Read More

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http://dx.doi.org/10.1002/jclp.23019DOI Listing

Memantine misuse and social networks: A content analysis of Internet self-reports.

Pharmacoepidemiol Drug Saf 2020 Jun 29. Epub 2020 Jun 29.

Faculty of Pharmacy, University of Strasbourg, Strasbourg, France.

Purpose: Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist currently used for moderate-to-severe Alzheimer's disease. Although the risk of memantine abuse is very low, other NMDA receptor antagonists, such as phencyclidine and ketamine, are well known to drug users. The purpose of this study was to collect data on social networks in order to identify unexpected forms of memantine abuse. Read More

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http://dx.doi.org/10.1002/pds.5070DOI Listing

Sensory hypersensitivity in Tourette syndrome: A review.

Brain Dev 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatrics, Division of Child Neurology, Vanderbilt Children's Hospital, United States.

Tourette syndrome (TS) is a neurodevelopmental disorder defined by tics, but most patients also experience bothersome sensory phenomena, in the form of premonitory urges and/or sensory hypersensitivity. Whereas premonitory urges are temporally paired with tics, sensory hypersensitivity is a constant, heightened awareness of external and/or internal stimuli. The intensity of sensory hypersensitivity does not strongly correlate with the severity of tics or premonitory urges, suggesting it is a dissociable clinical phenomenon. Read More

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http://dx.doi.org/10.1016/j.braindev.2020.06.003DOI Listing

Use of Real-Time Functional Magnetic Resonance Imaging-Based Neurofeedback to Downregulate Insular Cortex in Nicotine-Addicted Smokers.

J Vis Exp 2020 Jun 10(160). Epub 2020 Jun 10.

Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de Chile; Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile; Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile;

It has been more than a decade since the first functional magnetic resonance imaging (fMRI)-based neurofeedback approach was successfully implemented. Since then, various studies have demonstrated that participants can learn to voluntarily control a circumscribed brain region. Consequently, real-time fMRI (rtfMRI) provided a novel opportunity to study modifications of behavior due to manipulation of brain activity. Read More

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http://dx.doi.org/10.3791/59441DOI Listing

Therapeutic Implications Of Personality Disorders In Dermatology.

Dermatol Ther 2020 Jun 28:e13910. Epub 2020 Jun 28.

University of Guglielmo Marconi, Rome, Italy.

There is a significant psychiatric comorbidity that exists in multiple dermatological conditions, stemming from the patient's own psychological make up. This article reviews personality disorders and their types, which influence the course and prognosis of several psychodermatological disorders. Self-inflicted skin lesions, for example, are usually associated with obsessive-compulsive behavior, but they also share connections to Narcissistic and Borderline personality disorders. Read More

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http://dx.doi.org/10.1111/dth.13910DOI Listing

Delayed Bedtimes Are Associated With More Severe Obsessive-Compulsive Symptoms in Intensive Residential Treatment.

Behav Ther 2020 Jul 21;51(4):559-571. Epub 2019 Dec 21.

McLean Hospital/Harvard Medical School.

Delays in behavioral and biological circadian rhythms (e.g., sleep timing, melatonin secretion) are found more frequently in individuals with severe and treatment-resistant obsessive-compulsive disorder (OCD). Read More

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http://dx.doi.org/10.1016/j.beth.2019.12.006DOI Listing

Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice.

Neuropsychopharmacology 2020 Jun 25. Epub 2020 Jun 25.

Department of Basic Neurosciences, University of Geneva, Rue Michel-Servet 1, 1206, Geneva, Switzerland.

Obsessive-compulsive disorder (OCD) is a circuit disorder involving corticostriatal projections, which play a role in motor control. The Sapap3-knockout (KO) mouse is a mouse model to study OCD and recapitulates OCD-like compulsion through excessive grooming behavior, with skin lesions appearing at advanced age. Deficits in corticostriatal control provide a link to the pathophysiology of OCD. Read More

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http://dx.doi.org/10.1038/s41386-020-0747-3DOI Listing

Uncontrolled experiments: Treatment of contamination OCD during a pandemic.

Psychol Trauma 2020 Jun 25. Epub 2020 Jun 25.

Department of Psychiatry.

Patients suffering from obsessive-compulsive disorder are vulnerable to exacerbation of symptoms related to contamination and illness during the current pandemic. A cognitive-behavioral psychotherapy group for adolescent females with obsessive-compulsive disorder made effective adaptations to promote resilience to stressors and social isolation during the pandemic. (PsycInfo Database Record (c) 2020 APA, all rights reserved). Read More

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http://dx.doi.org/10.1037/tra0000806DOI Listing

Inherited duplication of the pseudoautosomal region Xq28 in a subject with Gilles de la Tourette syndrome and intellectual disability: a case report.

Mol Cytogenet 2020 22;13:23. Epub 2020 Jun 22.

Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Background: Tourette syndrome (TS) is a complex neurodevelopmental disorder (NDD) characterized by multiple chronic involuntary motor and vocal tics with onset during childhood or adolescence. Most TS patients present with additional comorbidities, typically attention deficit hyperactivity disorder (ADHD), obsessive- compulsive disorder (OCD), autism spectrum disorder (ASD) and intellectual disability (ID). Both TS and ID are genetically complex disorders that likely occur as a result of the effects of multiple genes interacting with other environmental factors. Read More

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http://dx.doi.org/10.1186/s13039-020-00493-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310047PMC

Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

Front Mol Neurosci 2020 8;13:89. Epub 2020 Jun 8.

Department of Pharmacology, Vanderbilt University, Nashville, TN, United States.

Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states as a result of environmental and intracellular stimuli, with regulation perturbed by disease-associated coding variants. Read More

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http://dx.doi.org/10.3389/fnmol.2020.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295033PMC

Using Mind-Body Modalities via Telemedicine during the COVID-19 Crisis: Cases in the Republic of Korea.

Int J Environ Res Public Health 2020 06 22;17(12). Epub 2020 Jun 22.

Department of Neuropsychiatry, Kyung Hee University Korean Medicine Hospital at Gangdong, Seoul 05278, Korea.

The coronavirus disease 2019 (COVID-19) pandemic affected the world, and its deleterious effects on human domestic life, society, economics, and especially on human mental health are expected to continue. Mental health experts highlighted health issues this pandemic may cause, such as depression, anxiety, obsessive compulsive disorder, and post-traumatic stress disorder. Mind-body intervention, such as mindfulness meditation, has accumulated sufficient empirical evidence supporting the efficacy in improving human mental health states and the use for this purpose has been increasing. Read More

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http://dx.doi.org/10.3390/ijerph17124477DOI Listing

Obsessive-compulsive disorder during the COVID-19 pandemic.

Braz J Psychiatry 2020 Jun 22. Epub 2020 Jun 22.

Programa Transtornos do Espectro Obsessivo-Compulsivo, Laboratório de Psicopatologia e Terapêutica Psiquiátrica (LIM-23), Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

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http://dx.doi.org/10.1590/1516-4446-2020-1189DOI Listing

The experience of orthorexia from the perspective of recovered orthorexics.

Eat Weight Disord 2020 Jun 23. Epub 2020 Jun 23.

School of Psychology, Aras an Phiarsaigh, Trinity College, College Green, Dublin 2, Ireland.

Purpose: Orthorexia is a proposed disorder that involves a pathological obsession with healthy eating. The condition has received much attention in popular media in recent years, but more empirical research is needed. Currently, orthorexia is an emerging construct with multiple proposed versions of diagnostic criteria, and there is confusion regarding the exact symptoms and pathology. Read More

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http://dx.doi.org/10.1007/s40519-020-00928-1DOI Listing

Sleep duration and timing in obsessive-compulsive disorder (OCD): evidence for circadian phase delay.

Sleep Med 2020 Apr 10;72:111-117. Epub 2020 Apr 10.

Binghamton University, Binghamton, NY, USA.

Objectives: To investigate potential delays in endogenous melatonin in individuals with obsessive-compulsive disorder (OCD).

Methods: First, data are presented for 15 individuals with OCD and matched healthy controls. Next, nine additional participants with OCD who did not have matched controls were added, resulting in a sample of 24 individuals with OCD. Read More

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http://dx.doi.org/10.1016/j.sleep.2020.03.021DOI Listing

Efficacy and Safety Of Gamma Ventral Capsulotomy for Treatment-Resistant Obsessive-Compulsive Disorder: A Single-Center Experience.

World Neurosurg 2020 Jun 18. Epub 2020 Jun 18.

Istanbul Bilgi University, Health Sciences Institute, Department of Psychiatry, Istanbul, Turkey. Electronic address:

Background: Obsessive-compulsive disorder (OCD) is a chronic disease with a lifetime prevalence of 3%, and is associated with severe impairment in familial and socio-occupational functioning. Gamma ventral capsulotomy (GVC) is a treatment choice in carefully chosen patients with few published reports. In this study, we aimed to report the efficacy and safety of GVC in 21 patients with treatment-resistant OCD. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.098DOI Listing

Intelligence quotient level and treatment of obsessive-compulsive disorders: Meta-analyses.

Med Hypotheses 2020 Jun 13;144:109995. Epub 2020 Jun 13.

Department of Psychiatricy, Zigong Mental Health Centre, Sichuan 643020, PR China. Electronic address:

Background: Obsessive-compulsive disorder (OCD) is a highly heterogeneous mental disorder that could affect mental capacity and requires different treatment methods. The purpose of this meta-analysis study was to evaluate the OCD subjects' intelligence quotient (IQ) and the effect of different treatments on OCD.

Methods: Through a systematic literature search up to December-2019, 108-studies were identified, with 8049-subjects with 6719-OCD subjects. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109995DOI Listing

Recognising and addressing the impact of COVID-19 on obsessive-compulsive disorder.

Lancet Psychiatry 2020 07;7(7):570-572

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/S2215-0366(20)30222-4DOI Listing

Pseudo-continuous arterial spin labeling MRI study of patients with obsessive-compulsive disorder.

Psychiatry Res Neuroimaging 2020 Jun 12;303:111124. Epub 2020 Jun 12.

National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan.

Arterial spin labeling (ASL) magnetic resonance imaging is a novel technique that can measure regional cerebral blood flow (rCBF). Here we used pseudo-continuous ASL (pCASL) to examine the structural and functional imaging data in patients with obsessive-compulsive disorder (OCD). We estimated the gray matter volume imaging and pCASL imaging data by means of a voxel-by-voxel statistical analysis. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2020.111124DOI Listing

Neurochemical correlates of behavioral treatment of pediatric trichotillomania.

J Affect Disord 2020 Aug 3;273:552-561. Epub 2020 May 3.

Division of Child & Adolescent Psychiatry, Jane & Terry Semel Institute for Neuroscience at UCLA, Los Angeles, CA 90024, USA. Electronic address:

Background: Trichotillomania (TTM) is a chronic and impairing psychiatric disorder with suspected dysfunctional cortico-striato-thalamo-cortical (CSTC) circuit activity reflecting excitatory/inhibitory signaling imbalance. TTM neurochemistry is understudied, with no prior research using magnetic resonance spectroscopy (MRS). This pilot investigation examined associations between TTM diagnosis, symptom severity, and response to behavioral treatment with MRS neurometabolites glutamate (Glu) and γ-aminobutyric acid (GABA) in CSTC structures. Read More

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http://dx.doi.org/10.1016/j.jad.2020.04.061DOI Listing

Abrupt and Severe Obsessive-Compulsive Disorder in an 11-Year-Old Girl-PANDAS/PANS Syndrome: An Entity to be Considered-Management Implications.

J Dev Behav Pediatr 2020 Jun/Jul;41(5):406-409

Psychiatry, Hospital Clínico Universitario de Valencia, Valencia, Spain.

Case: An 11-year-old preadolescent girl was taken to the pediatric emergency room by her parents because of emotional overload.Her clinical history started 3 weeks before the visit, coinciding with a self-limited gastrointestinal infection affecting the whole family. Her obsessive behavior first appeared in the school setting; she tried to write perfectly, needing to make repeated corrections and ripping out multiple sheets from her notebooks when she made mistakes. Read More

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http://dx.doi.org/10.1097/DBP.0000000000000807DOI Listing