19,141 results match your criteria Obsessive-Compulsive Disorder


Case Studies in Neuroscience: The electrophysiology of a human obsession in nucleus accumbens.

J Neurophysiol 2019 Apr 24. Epub 2019 Apr 24.

Stanford, United States.

Microelectrode recordings were performed during awake deep brain stimulation surgery for obsessive-compulsive disorder, revealing robust brain oscillations that were plainly visible throughout the ventral striatum. There was an elegant topological correspondence between each oscillation and the underlying brain anatomy, most prominently a ~35Hz gamma-oscillation specific to the nucleus accumbens. Direct provocation of the patient's contamination obsession modulated both firing rate and gamma-oscillation amplitude within the nucleus accumbens. Read More

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http://dx.doi.org/10.1152/jn.00096.2019DOI Listing

Seasonality Patterns of Internet Searches on Mental Health: Exploratory Infodemiology Study.

JMIR Ment Health 2019 Apr 24;6(4):e12974. Epub 2019 Apr 24.

Anxiety Treatment and Research Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Background: The study of seasonal patterns of public interest in psychiatric disorders has important theoretical and practical implications for service planning and delivery. The recent explosion of internet searches suggests that mining search databases yields unique information on public interest in mental health disorders, which is a significantly more affordable approach than population health studies.

Objective: This study aimed to investigate seasonal patterns of internet mental health queries in Ontario, Canada. Read More

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http://dx.doi.org/10.2196/12974DOI Listing

Epidemiological and Clinical Gender Differences in OCD.

Curr Psychiatry Rep 2019 Apr 23;21(5):36. Epub 2019 Apr 23.

Department of Psychology, Florida State University, PO Box 3064301, Tallahassee, FL, 32306, USA.

Purpose Of Review: This review highlights recent research regarding gender differences in OCD, with a focus on prevalence, course of illness, symptom presentation, comorbidity, and treatment response.

Recent Findings: Overall, findings remain mixed. OCD may be more common among males in childhood, but is more common among females in adolescence and adulthood. Read More

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http://dx.doi.org/10.1007/s11920-019-1015-2DOI Listing

Patient Satisfaction and Treatments Offered to Swedish Patients with Suspected Pediatric Acute-Onset Neuropsychiatric Syndrome and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections.

J Child Adolesc Psychopharmacol 2019 Apr 19. Epub 2019 Apr 19.

1 Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.

Pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are subtypes of Obsessive-Compulsive Disorder (OCD) with suggested autoimmune etiology. Immunomodulatory treatments have been introduced as treatment options. A recent systematic review concluded that the evidence for all treatment options for PANS and PANDAS is inconclusive. Read More

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http://dx.doi.org/10.1089/cap.2018.0141DOI Listing

A Study of Assessment of Knowledge of Childhood Autism among Medical Students in Mumbai.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):164-169

Department of Psychiatry, Topiwala National Medical College and BYL Charitable Nair Hospital, Mumbai, Maharashtra, India.

Aims: This study is to study the knowledge and awareness on autism among medical students and the factors which impact their knowledge on autism.

Settings And Design: For the study, a multicenter cross-sectional research has been carried out among medical students in seven medical colleges in Mumbai.

Subjects And Methods: A total of 201 final-year medical students from seven medical colleges in Mumbai completed the knowledge on childhood autism among healthcare workers (KCAHW) survey and a semi-structured pro forma. Read More

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http://www.annalsofian.org/preprintarticle.asp?id=254340;typ
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http://dx.doi.org/10.4103/aian.AIAN_486_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472225PMC
April 2019
2 Reads

Psychopathological disorders in Prader-Willi syndrome.

Endocrinol Diabetes Nutr 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Endocrinología y Nutrición, Hospital Universitari Parc Taulí, Universidad Autónoma de Barcelona, Sabadell (Barcelona), España. Electronic address:

Prader-Willi syndrome is a genetic disorder caused by chromosomal changes in segment 15q11-q13 including cognitive, mental, and behavioral symptoms, as well as a specific physical phenotype. Both the most common psychopathological changes (intellectual disability, obsessions, impulsivity, autism spectrum disorders, self-injuries) and the main psychiatric comorbidities (affective disorders, psychosis, obsessive-compulsive disorder, autism spectrum disorder) are characterized by a great heterogeneity, which warrants the need for better identification of their frequency and clinical signs. In addition to its effects on body compositionand hypotony, growth hormone has been shown to be useful for regulating patient behavior, and psychoactive drugs are also an option. Read More

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http://dx.doi.org/10.1016/j.endinu.2019.03.004DOI Listing

Aberrant functional connectivity density in patients with treatment-refractory obsessive-compulsive disorder: a pilot study.

J Int Med Res 2019 Apr 21:300060518807058. Epub 2019 Apr 21.

1 Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang Province, China.

Objective: Functional connectivity (FC) is altered in patients with obsessive-compulsive disorder (OCD). Most previous studies have focused on the strength of FC in patients with OCD; few have examined the number of functional connections in these patients. The number of functional connections is an important index for assessing aberrant FC. Read More

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http://dx.doi.org/10.1177/0300060518807058DOI Listing

Exploring the role of BDNF DNA methylation and hydroxymethylation in patients with obsessive compulsive disorder.

J Psychiatr Res 2019 Apr 6;114:17-23. Epub 2019 Apr 6.

University of Milan, Department of Biomedical and Clinical Sciences Luigi Sacco, Milano, Italy; CRC "Aldo Ravelli", University of Milan, Milano, Italy; Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA. Electronic address:

Obsessive-compulsive disorder (OCD) is a clinically heterogeneous neuropsychiatric condition associated with profound disability, whose susceptibility, stemming from genetic and environmental factors that intersect with each other, is still under investigation. In this perspective, we sought to explore the transcriptional regulation of Brain Derived Neurotrophic Factor (BDNF), a promising candidate biomarker in both development and etiology of different neuropsychiatric conditions, in peripheral blood mononuclear cells from OCD patients and healthy controls. In particular, we focused on BDNF gene expression and interrogated in depth DNA methylation and hydroxymethylation at gene promoters (exons I, IV and IX) in a sample of OCD patients attending a tertiary OCD Clinic to receive guidelines-recommended treatment, and matched controls. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.04.006DOI Listing

Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population.

CNS Neurosci Ther 2019 Apr 19. Epub 2019 Apr 19.

Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Aims: Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.

Methods: Three μ-opioid receptor gene (OPRM1) variants and two κ-opioid receptor gene (OPRK1) variants were examined in 314 male patients with AUD and 324 male controls. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cns.13138
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http://dx.doi.org/10.1111/cns.13138DOI Listing
April 2019
1 Read

Psychiatric Disorders and Alcohol Consumption Among Low-Income African Americans:Gender Differences.

Brain Sci 2019 Apr 18;9(4). Epub 2019 Apr 18.

Department of Family Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.

Background: Although cooccurrence of nonsubstance use disorders (non-SUDs) and substance use is well-established in the literature, most of what we know in this regard is derived from studies that have recruited predominantly White sample populations. As a result, there is a gap in knowledge on this link among low-income African Americans (AAs). There is also a need to understand how low-income AA men and women differ in these associations. Read More

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http://dx.doi.org/10.3390/brainsci9040086DOI Listing

Efficacy of repetitive transcranial magnetic stimulation in the treatment of depression with comorbid anxiety disorders.

J Affect Disord 2019 Mar 30;252:435-439. Epub 2019 Mar 30.

The Adelaide Clinic, Ramsay Health Care (SA) Mental Health Services, South Australia, Australia; Discipline of Psychiatry, School of Medicine, The University of Adelaide, South Australia, Australia; Northern Adelaide Local Health Network, South Australia, Australia. Electronic address:

Background: The presence of comorbid anxiety is generally associated with poorer treatment outcomes in people with depression. Repetitive transcranial magnetic stimulation (rTMS) has been shown to be effective for treatment resistant depression, but there has been little research examining rTMS in depressed patients with comorbid anxiety disorders. This study aimed to investigate the efficacy of rTMS in patients with treatment resistant Major Depressive Disorder (MDD) and comorbid anxiety disorders. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.085DOI Listing

Toward Precision Medicine: Prediction of Deep Brain Stimulation Targets of the Ventral Internal Capsule for Obsessive-Compulsive Disorder.

Authors:
Valerie Voon

Biol Psychiatry 2019 May;85(9):708-710

Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.03.969DOI Listing

Meningioma and psychiatric symptoms: An individual patient data analysis.

Asian J Psychiatr 2019 Mar 28;42:94-103. Epub 2019 Mar 28.

Department of Psychiatry, Dr Ram Manohar Lohia Hospital PGIMER, New Delhi, India.

Meningioma is a slow-growing benign tumor arising from meninges and is usually asymptomatic. Though neuropsychiatric symptoms are common in patients with brain tumors, they often can be the only manifestation in cases of meningioma. Meningiomas might present with mood symptoms, psychosis, memory disturbances, personality changes, anxiety, or anorexia nervosa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18762018183113
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http://dx.doi.org/10.1016/j.ajp.2019.03.029DOI Listing
March 2019
3 Reads

PANDAS/PANS in childhood: Controversies and evidence.

Paediatr Child Health 2019 May 9;24(2):85-91. Epub 2018 Dec 9.

Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Since first defined in 1998, paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and its later, broader iteration, paediatric acute-onset neuropsychiatric syndrome (PANS), have garnered significant attention and controversy. The role of streptococcal infection in children with explosive onset obsessive-compulsive disorder and new onset tics, the natural history of this entity, and the role of symptomatic and disease-modifying therapies, including antibiotics, immunotherapy, and psychoactive drugs, are all issues that have yet to be definitively addressed. While definitive proof of the autoimmune hypothesis of PANDAS is lacking, given the heightened attention to this entity and apparent rise in use of this diagnostic category, addressing questions around diagnosis, treatment, and etiology is imperative. Read More

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https://academic.oup.com/pch/article/24/2/85/5236858
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http://dx.doi.org/10.1093/pch/pxy145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462125PMC
May 2019
1 Read

Roles of 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in early- and late-onset obsessive-compulsive disorder.

Indian J Psychiatry 2019 Mar-Apr;61(2):161-166

Department of Psychiatry, Aydın Government Hospital, Aydin, Turkey.

Background: The C677T and A1298C mutations of 5,10-methylenetetrahydrofolate reductase (MTHFR) have been linked with conditions such as depression, bipolar disorder, and schizophrenia, but there are not clear the relationship between MTHFR polymorphisms and obsessive-compulsive disorder (OCD).

Aim: The current study was planned to investigate the link between the MTHFR polymorphisms and OCD in patients to reveal any potential correlations that may be used as a novel marker in diagnosis of people who are in high-risk group of developing OCD.

Materials And Methods: Blood samples from 64 highly characterized symptomatic cases and 64 gender- and age-matched control participants were analyzed for MTHFR C677T and A1298C gene variants. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_370_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425796PMC
April 2019
1 Read

The impact of attention deficit hyperactivity disorder in obsessive-compulsive disorder subjects.

Depress Anxiety 2019 Apr 16. Epub 2019 Apr 16.

Child and Adolescent Psychiatry Unit (UPIA), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.

Background: Recent findings suggest an association between attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). Thus, we evaluated the clinical associated features of ADHD in a large sample of adult OCD patients.

Methods: A cross-sectional study including 955 adult patients with OCD from the Brazilian Research Consortium of Obsessive-Compulsive Spectrum Disorders (C-TOC). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/da.22898
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http://dx.doi.org/10.1002/da.22898DOI Listing
April 2019
2 Reads

Factor structure, validity, and reliability of a Persian version of the Body and Appearance Self-conscious Emotions Scale.

J Health Psychol 2019 Apr 16:1359105319842928. Epub 2019 Apr 16.

2 McGill University, Canada.

This study examined the psychometric properties of a Persian translation of the Body and Appearance Self-conscious Emotions Scale. A total of 393 university students from Iran completed the Body and Appearance Self-conscious Emotions Scale, along with measures of depression, self-esteem, affect, body appreciation, physical self-perceptions, personality, obsessive-compulsive disorder, and body dysmorphic disorder. Confirmatory factor analysis indicated that the four-factor structure had adequate fit. Read More

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http://dx.doi.org/10.1177/1359105319842928DOI Listing
April 2019
3 Reads

Defining compulsive exercise in eating disorders: acknowledging the exercise paradox and exercise obsessions.

J Eat Disord 2019 4;7. Epub 2019 Apr 4.

3Department of Psychology, UiT -The Arctic University of Norway, Tromsø, Norway.

Recently Dittmer et al. (JED 6:1-9, 2018). suggested a transdiagnostic definition and a clinical assessment for compulsive exercise in adolescents and adults with eating disorders. Read More

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http://dx.doi.org/10.1186/s40337-019-0238-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448210PMC
April 2019
1 Read

Prevalence, comorbidity, quality of life and use of services of obsessive-compulsive disorder and subthreshold obsessive-compulsive symptoms in the general adult population of Greece.

Int J Psychiatry Clin Pract 2019 Apr 15:1-10. Epub 2019 Apr 15.

a Department of Psychiatry, School of Medicine , University of Ioannina , Ioannina , Greece.

Objective: We aimed to describe the epidemiology of obsessive-compulsive disorder (OCD) and related subthreshold symptoms in the general population of Greece and to assess the comorbidity, use of health services and impact on quality of life of these syndromes in the general population.

Methods: This was a secondary analysis of the 2009-2010 general population Greek psychiatric morbidity survey (4902 participants living in private households, response rate 54%). Psychiatric disorders were assessed with the revised Clinical Interview Schedule (CIS-R). Read More

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https://www.tandfonline.com/doi/full/10.1080/13651501.2019.1
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http://dx.doi.org/10.1080/13651501.2019.1588327DOI Listing
April 2019
2 Reads

Measuring treatment outcome in patients with anxiety disorders: A comparison of the responsiveness of generic and disorder-specific instruments.

J Anxiety Disord 2019 Apr 6;64:55-63. Epub 2019 Apr 6.

Institute of Psychology, Faculty of Social Sciences, Leiden University, Pieter De La Court Building, P.O. Box 9555, 2300 RB Leiden, the Netherlands; Stichting Benchmark GGZ, Rembrandtlaan 46, 3723 BK Bilthoven, the Netherlands. Electronic address:

Background: For routine outcome monitoring, generic (i.e., broad-based) and disorder-specific instruments are used to monitor patient progress. Read More

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http://dx.doi.org/10.1016/j.janxdis.2019.04.001DOI Listing
April 2019
1 Read

A randomised controlled trial of guided internet-based cognitive behavioural therapy for perfectionism: Effects on psychopathology and transdiagnostic processes.

J Behav Ther Exp Psychiatry 2019 Mar 30;64:113-122. Epub 2019 Mar 30.

Institute of Child Health Population, Policy and Practice Programme, University College London, 30 Guilford Street, London, WC1N 1EH, United Kingdom. Electronic address:

Background And Objectives: Perfectionism is a transdiagnostic process that has been associated with a range of psychopathology and also with other transdiagnostic processes. We have previously shown that guided internet-based cognitive behavioural therapy (ICBT) can reduce symptoms of dysfunctional perfectionism, however, no impact was observed on symptoms of depression and anxiety. Here we explore the impact of guided ICBT for perfectionism on symptoms of other associated psychopathology, specifically obsessive-compulsive disorder (OCD) and eating disorders, and also on other associated transdiagnostic processes (self-esteem, intolerance of uncertainty, and self-compassion). Read More

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http://dx.doi.org/10.1016/j.jbtep.2019.03.007DOI Listing
March 2019
1 Read

Checking and washing rituals are reflected in altered cortical thickness in obsessive-compulsive disorder.

Cortex 2019 Mar 26;117:147-156. Epub 2019 Mar 26.

Psychiatric Brain & Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.

There is growing evidence for structural brain alterations in obsessive-compulsive disorder (OCD). The overall picture is however rather heterogeneous. To detect meaningful associations between clinical symptom profiles and structural alterations, we applied a classification approach, the k-means cluster analysis on clinical data, i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00109452193012
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http://dx.doi.org/10.1016/j.cortex.2019.03.012DOI Listing
March 2019
2 Reads

Psychiatric Neurosurgery: A Survey on the Perceptions of Psychiatrists and Residents.

Can J Neurol Sci 2019 Apr 12:1-8. Epub 2019 Apr 12.

Department of Psychiatry, McGill University Health Center,McGill University,Montreal, Quebec,Canada.

Objectives: To evaluate the attitudes and perceptions of psychiatrists and psychiatry residents regarding neurosurgical procedures for treating psychiatric disorders and to identify potential barriers to patient referral.

Methods: A survey consisting of 25 questions was created using SurveyMonkey and was distributed to psychiatrists and psychiatry residents in Quebec. The study was approved by the McGill University Health Center's Research Ethics Board. Read More

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http://dx.doi.org/10.1017/cjn.2019.5DOI Listing
April 2019
1 Read

Experiences of (young) women after out of home placement: An examination of personality disorder symptoms through the lens of child maltreatment.

Child Abuse Negl 2019 Apr 8;92:116-125. Epub 2019 Apr 8.

Université de Sherbrooke, Canada.

Background: Child maltreatment has been associated with the development of various mental health problems, including the development of personality disorders.

Objective: This study investigated the association between child maltreatment and personality disorder symptoms in 125 women who transitioned out of residential care.

Method: The Child Trauma Questionnaire was used for the measurement of child maltreatment, and Personality disorder symptoms were measured using the Personality Diagnostic Questionnaire 4 + . Read More

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http://dx.doi.org/10.1016/j.chiabu.2019.03.022DOI Listing
April 2019
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Brain neurochemistry in unmedicated Obsessive Compulsive Disorder patients and effects of 12-week escitalopram treatment: A H-magnetic resonance spectroscopy study.

Psychiatry Clin Neurosci 2019 Apr 11. Epub 2019 Apr 11.

Department of NMR and MRI facility, All India Institute of Medical Sciences, New Delhi, India.

Aim: The purpose of this study, using H-Magnetic Resonance Spectroscopy ( H-MRS), was to examine the treatment related changes in the neurochemicals in 28 unmedicated obsessive compulsive disorder (OCD) patients METHODS: We included subjects diagnosed with OCD (n=28) with a total duration of illness <5 years as a study group and matched healthy controls (n=26). The inclusion criteria for OCD group was: right-handed individuals, aged >18 years, not on any specific treatment for OCD for last >8 weeks with no other psychiatric comorbidity. A pre-post and case-control design was employed in which OCD patients underwent H-MRS at baseline and 12 weeks after treatment with escitalopram (n=21). Read More

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http://dx.doi.org/10.1111/pcn.12850DOI Listing
April 2019
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Caudate volume differences among treatment responders, non-responders and controls in children with obsessive-compulsive disorder.

Eur Child Adolesc Psychiatry 2019 Apr 10. Epub 2019 Apr 10.

National Institute for Developmental Psychiatry for Children and Adolescents (INPD), Sao Paulo, Brazil.

Treatment response in obsessive-compulsive disorder (OCD) is heterogeneous and the neurobiological underpinnings of such variability are unknown. To investigate this issue, we looked for differences in brain structures possibly associated with treatment response in children with OCD. 29 children with OCD (7-17 years) and 28 age-matched controls underwent structural magnetic resonance imaging. Read More

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http://dx.doi.org/10.1007/s00787-019-01320-wDOI Listing
April 2019
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The Prevalence of Specific Phobia by Age in an Italian Nationwide Survey: How Much Does it Affect the Quality of Life?

Clin Pract Epidemiol Ment Health 2019 20;15:30-37. Epub 2019 Feb 20.

University of Cagliari,Cagliari,Italy.

Introduction: The study aimed to see if a community survey conducted by clinical interviewers with semi-structured psychiatric interviews shows lifetime prevalence rates of Specific Phobia (SP) similar to those found by surveys carried out by lay interviewers and if the high level of impairment found in SP may be confirmed.

Methods: This is a community survey on an Italian nationwide sample randomly selected from registers of municipalities. Tools: semi-structured ANTAS psychiatric interview derived from the SCID-DSM-IV, carried out by clinicians (psychologists or physicians); Short Form Health Survey (SF-12) as a measure of Quality of Life (QoL). Read More

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https://clinical-practice-and-epidemiology-in-mental-health.
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http://dx.doi.org/10.2174/1745017901915010030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407652PMC
February 2019
4 Reads

The Cognitive Profile of Persons with Obsessive Compulsive Disorder with and without Autism Spectrum Disorder.

Clin Pract Epidemiol Ment Health 2018 30;14:304-311. Epub 2018 Nov 30.

Department of Social and Psychological Studies, Section of Psychology, Karlstad University, Karlstad, Sweden.

Introduction: Autistic Spectrum Disorder (ASD) is often comorbid with Obsessive Compulsive Disorder (OCD). But to what extent can obsessional symptoms in individuals with ASD be considered "genuinely" comorbid OCD - or are there other mechanisms that are related to ASD? Which mechanisms in OCD with and without ASD share common features? People with ASD have a cognitive profile characterized by "mindblindness"; the antecedent is often referred to in terms of not knowing how to perform or behave and this is the cause of discomfort. This raises the question whether individuals with ASD and comorbid OCD share the same cognitive elements of responsibility interpretation and the same fear of causing harm as individuals who merely have OCD. Read More

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http://dx.doi.org/10.2174/1745017901814010304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407650PMC
November 2018
1 Read

Obsessions Across Two Cultures: A Comparison of Belgian and Turkish Non-clinical Samples.

Front Psychol 2019 26;10:657. Epub 2019 Mar 26.

Center for Social and Cultural Psychology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.

There is a growing interest in the role of culture in Obsessive-Compulsive Disorder, yet cultural studies to date have suffered from methodological limitations and lack a clear theoretical framework. In the current study, we adopted a rigorous methodological approach, and a clear cultural psychological framework. We compared the structure and frequency of obsessions in non-clinical samples ( = 706) from Belgium, a Western culture, and Turkey, a non-Western cultural context. Read More

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https://www.frontiersin.org/article/10.3389/fpsyg.2019.00657
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http://dx.doi.org/10.3389/fpsyg.2019.00657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443853PMC
March 2019
3 Reads

Sex-Gender Comparisons in Comorbidities of Children and Adolescents With High-Functioning Autism Spectrum Disorder.

Front Psychiatry 2019 26;10:159. Epub 2019 Mar 26.

Basic Medical Sciences Neuroscience and Sense Organs Department, University of Bari Aldo Moro, Bari, Italy.

Over the last few years, new studies focused their attention on the gender-related features in high-functioning autism spectrum disorder (HFA), often leading to controversial results. Another interesting aspect of these subtype of patients is linked to the complexity of clinical presentation, where besides core symptoms, other co-occurrence disorders may complicate the diagnostic evaluation. Therefore, we retrospectively studied 159 HFA patients, male and female, investigating their comorbidities and to find any gender difference. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445051PMC
March 2019
1 Read

Relationship between toxoplasmosis and obsessive compulsive disorder: A systematic review and meta-analysis.

PLoS Negl Trop Dis 2019 04 10;13(4):e0007306. Epub 2019 Apr 10.

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Background: A few studies investigated the relationship between toxoplasmosis and mental disorders, such as obsessive compulsive disorder (OCD). However, the specific nature of the association between Toxoplasma gondii (T. gondii) infection and OCD is not yet clear. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007306DOI Listing
April 2019
2 Reads

Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications.

Philos Trans R Soc Lond B Biol Sci 2019 Feb;374(1766):20180128

3 School of Psychology, Cardiff University , Tower Building, 70 Park Place, Cardiff CF10 3AT , UK.

Our willingness to take risks, our ability to wait or the speed with which to make decisions are central features of our personality. However, it is now recognized that impulsive and risk-taking behaviours are not a unitary construct, and different aspects can be both psychologically and neurally dissociated. The range of neurochemicals and brain systems that govern these behaviours is extensive, and this may be a contributing factor to the phenotypic range seen in the human population. Read More

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http://dx.doi.org/10.1098/rstb.2018.0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335461PMC
February 2019

Altered reward-related effective connectivity in obsessive-compulsive disorder: an fMRI study

J Psychiatry Neurosci 2019 Apr 9;44(3):1-12. Epub 2019 Apr 9.

From the Department of Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany (Rus, Reess, Wohlschläger, Koch); the TUM-Neuroimaging Center (TUM-NIC) School of Medicine of Klinikum rechts der Isar, Technische Universität München TUM, Ismaninger Strasse 22, 81675 Munich, Germany (Rus, Reess, Wohlschläger, Koch); the Research Unit of the Buhl-Strohmaier Foundation for Pediatric Neuroorthopaedics and Cerebral Palsy, Department of Orthopedics and Sports Orthopedics, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany (Alves-Pinto); the Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich, Germany (Rus, Reess, Koch); the Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany (Wagner); the Windach Institute and Hospital of Neurobehavioural Research and Therapy (WINTR), Windach, Germany (Berberich); and the Department of Neuroradiology, University of Zürich, Zürich, Switzerland (Rus).

Background: Obsessive–compulsive disorder (OCD) is characterized by anxiety-provoking, obsessive thoughts. Patients usually react to these thoughts with repetitive behaviours that reduce anxiety and are perceived as rewarding. Hence, reward plays a major role in the psychopathology of OCD. Read More

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http://dx.doi.org/10.1503/jpn.180195DOI Listing
April 2019
3 Reads

Brain Stimulation in Obsessive-Compulsive Disorder (OCD): A Systematic Review.

Curr Neuropharmacol 2019 04 9. Epub 2019 Apr 9.

Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University; "Sant'Andrea" University Hospital, Rome. Italy.

Background: Obsessive-compulsive disorder (OCD) is highly prevalent, severe, chronic, and disabling. There is need for alternative strategies for treatment-resistant OCD.

Objective: This review aims to assess the effect of brain stimulation techniques in OCD. Read More

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http://dx.doi.org/10.2174/1570159X17666190409142555DOI Listing
April 2019
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Hippocampus and amygdalar volumes in patients with obsessive-compulsive personality disorder.

J Clin Neurosci 2019 Apr 5. Epub 2019 Apr 5.

Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey.

Objectives: Moving from the point that there might be an association between the neuroanatomy of obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder, we decided to examine the volumes of hippocampus and amygdala of patients with obsessive-compulsive personality disorder, which was previously evaluated in OCD patients by us.

Methods: Volumes of the hippocampus, and amygdala were measured by magnetic resonance imaging (MRI) in patients with obsessive-compulsive personality disorder and healthy control subjects. Manual tracing was used. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.060DOI Listing
April 2019
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Volumetric MRI study of orbito-frontal cortex and thalamus in obsessive-compulsive personality disorder.

J Clin Neurosci 2019 Apr 5. Epub 2019 Apr 5.

Department of Radiology, Firat University School of Medicine, Elazig, Turkey.

Objectives: Obsessive compulsive personality disorder (OCPD) is currently thought to bear a close relationship with obsessive-compulsive disorder (OCD), and other compulsive disorders such as eating disorder and autistic spectrum disorder, as well as with the personality disorders, focusing on some important dimensions like phenomenology, heritability, environmental risk factors, comorbidity, course of illness, neurocognitive endophenotypes, and treatment response. In the present study, when we have taken into consideration the knowledge aforementioned, we aimed to examine OFC and thalamus volumes in patients with OCPD.

Methods: We comparatively measured orbito-frontal cortex (OFC) and thalamus volumes of patients with OCPD and healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.062DOI Listing
April 2019
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Hoarding: A meta-analysis of age of onset.

Depress Anxiety 2019 Apr 8. Epub 2019 Apr 8.

Department of Psychiatry, Center for OCD, Anxiety, and Related Disorders, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida.

Hoarding disorder is present in 2-6% of the population and can have an immense impact on the lives of patients and their families. Before its inclusion the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, pathological hoarding was often characterized as a symptom of obsessive-compulsive disorder, and several different diagnostic assessment methods were used to identify and characterize it. Although the age of onset of pathological hoarding is an important epidemiological measure, as clarifying the age of onset of hoarding symptoms may allow for early identification and implementation of evidence-based treatments before symptoms become clinically significant, the typical age of onset of hoarding is still uncertain. Read More

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http://dx.doi.org/10.1002/da.22896DOI Listing
April 2019
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Predictors of concurrent depressive symptoms in patients with obsessive-compulsive disorder.

Psychiatry Res 2019 Apr 4. Epub 2019 Apr 4.

Rogers Memorial Hospital, Oconomowoc, WI, USA.

Many patients with obsessive-compulsive disorder (OCD) exhibit concurrent depressive symptoms, which are associated with negative psychological outcomes. Yet little research has focused on identifying factors that predict depressive symptoms in OCD. The current study examined three transdiagnostic constructs-anxiety sensitivity (AS), intolerance of uncertainty (IU), and worry-as predictors of depressive symptom severity in a sample of treatment-seeking adults with a primary diagnosis of OCD (N = 93). Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.052DOI Listing
April 2019
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Obsessive Compulsive Disorder: A Pathology of Self-Confidence?

Trends Cogn Sci 2019 Apr 3. Epub 2019 Apr 3.

Academic Medical Centre, Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands; Institute of Logic, Language and Computation, University of Amsterdam, Amsterdam, The Netherlands.

A striking change OCD patients repeatedly describe following treatment with deep brain stimulation (DBS) of the ventral anterior limb of internal capsule (vALIC) is an immediate increase in self-confidence. We show how the DBS-induced changes in self-confidence reported by our patients can be understood neurocognitively in terms of active inference. Read More

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http://dx.doi.org/10.1016/j.tics.2019.02.005DOI Listing
April 2019
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The top 100 cited articles on Obsessive Compulsive Disorder (OCD): A citation analysis.

Asian J Psychiatr 2019 Mar 26;42:34-41. Epub 2019 Mar 26.

All India Institute of Medical Sciences, Ansari Nagar, AIIMS, 110029, South West Delhi, India. Electronic address:

There is an exponential growth in the field of biomedical literature over the years. Although numerous articles are published every year, few of them present important conceptual advances in that particular field and are found to be influential in the evolution of the field. The number of citations a publication receives can be used as a proxy marker of its impact on the field. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.03.025DOI Listing
March 2019
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Relevance of extended protocol and maintenance TMS in obsessive-compulsive disorder: A case report.

Asian J Psychiatr 2019 Mar 26;42:32-33. Epub 2019 Mar 26.

King George's Medical University, Chowk, Lucknow, 226003, India.

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http://dx.doi.org/10.1016/j.ajp.2019.03.014DOI Listing
March 2019
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Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function.

Nat Commun 2019 04 4;10(1):1536. Epub 2019 Apr 4.

Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Boston, MA, 02129, USA.

Deep brain stimulation (DBS) is a circuit-oriented treatment for mental disorders. Unfortunately, even well-conducted psychiatric DBS clinical trials have yielded inconsistent symptom relief, in part because DBS' mechanism(s) of action are unclear. One clue to those mechanisms may lie in the efficacy of ventral internal capsule/ventral striatum (VCVS) DBS in both major depression (MDD) and obsessive-compulsive disorder (OCD). Read More

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http://dx.doi.org/10.1038/s41467-019-09557-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449385PMC
April 2019
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Tracking the mental health of a nation: prevalence and correlates of mental disorders in the second Singapore mental health study.

Epidemiol Psychiatr Sci 2019 Apr 5:1-10. Epub 2019 Apr 5.

Research Division,Institute of Mental Health,Singapore.

AimsThe second Singapore Mental Health Study (SMHS) - a nationwide, cross-sectional, epidemiological survey - was initiated in 2016 with the intent of tracking the state of mental health of the general population in Singapore. The study employed the same methodology as the first survey initiated in 2010. The SMHS 2016 aimed to (i) establish the 12-month and lifetime prevalence and correlates of major depressive disorder (MDD), dysthymia, bipolar disorder, generalised anxiety disorder (GAD), obsessive compulsive disorder (OCD) and alcohol use disorder (AUD) (which included alcohol abuse and dependence) and (ii) compare the prevalence of these disorders with reference to data from the SMHS 2010. Read More

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http://dx.doi.org/10.1017/S2045796019000179DOI Listing
April 2019
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Obsessive-Compulsive Disorder: Puzzles and Prospects.

Neuron 2019 Apr;102(1):27-47

Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK. Electronic address:

Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents several challenges for neuroscience. Recent advances in its genetic and developmental causation, as well as its neuropsychological basis, are reviewed. Hypotheses concerning an imbalance between goal-directed and habitual behavior together with neural correlates in cortico-striatal circuitry are evaluated and contrasted with metacognitive theories. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08966273193007
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http://dx.doi.org/10.1016/j.neuron.2019.01.046DOI Listing
April 2019
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Refining the Analysis of Mechanism-Outcome Relationships for Anxiety Treatment: A Preliminary Investigation Using Mixed Models.

Behav Modif 2019 Apr 3:145445519841055. Epub 2019 Apr 3.

1 San Diego State University/University of California, San Diego.

Although efficacious treatments exist for anxiety disorders, issues remain regarding how best to conceptualize and measure purported change processes in clinical research. In the current study, we examined the relationship between treatment-specific (exposure therapy, attention bias modification [ABM]) as well as more general change processes with symptoms within a transdiagnostic sample using mixed models. Results indicated that slope of self-efficacy across treatment and between-session habituation across identical exposures was associated with slope of symptom change. Read More

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http://dx.doi.org/10.1177/0145445519841055DOI Listing
April 2019
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Psychometrics of the SCL-90-R and Development and Testing of Brief Versions SCL-45-I and SCL-9-I in Infertile Couples.

Nurs Res 2019 Apr 1. Epub 2019 Apr 1.

Professor, University of Deusto School of Psychology and Education, Bilbao, Spain Associate Professor, Universidad Europea del Atlántico School of Health Sciences, Santander, Spain Psychotherapist, Arratia Psychological Center, Bilbao, Spain Associate Professor, University of Deusto School of Psychology and Education, Bilbao, Spain.

Background: Although infertile couples are mentally healthy, dealing with infertility and assisted reproductive technology (ART) treatment is usually associated with psychological distress. It would therefore be useful to have short, multidimensional instruments to be able to identify people who present more intense emotional reactions and follow-up their emotional distress throughout the ART.

Objectives: The goals of the study were to analyze the psychometric adequacy of the original 90-item version of the Symptom Checklist (SCL-90) in a sample of Spanish women and their partners undergoing ART, as well as to develop and analyze two brief versions of the SCL-90, given the absence of adequate short versions for this population. Read More

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http://dx.doi.org/10.1097/NNR.0000000000000363DOI Listing
April 2019
3 Reads

The Parkinson's phenome-traits associated with Parkinson's disease in a broadly phenotyped cohort.

NPJ Parkinsons Dis 2019 27;5. Epub 2019 Mar 27.

123andMe, Inc., 899W Evelyn Avenue, Mountain View, CA 94041 USA.

In order to systematically describe the Parkinson's disease phenome, we performed a series of 832 cross-sectional case-control analyses in a large database. Responses to 832 online survey-based phenotypes including diseases, medications, and environmental exposures were analyzed in 23andMe research participants. For each phenotype, survey respondents were used to construct a cohort of Parkinson's disease cases and age-matched and sex-matched controls, and an association test was performed using logistic regression. Read More

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http://dx.doi.org/10.1038/s41531-019-0077-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437217PMC
March 2019
5 Reads