21,520 results match your criteria Obsessive-Compulsive Disorder


Transfer of face-to-face group therapies into online group-chats in a psychiatric outpatient setting during the COVID-19 pandemic.

JMIR Form Res 2021 Jun 8. Epub 2021 Jun 8.

Department of Psychiatry and Psychotherapy, University Leipzig Medical Center, Semmelweisstraße 10Haus 13, Leipzig, DE.

Background: At the height of the COVID-19 pandemic, several mental health care providers were obliged to shut down outpatient services, including group therapies and psychoeducational sessions. The lockdown in many countries is a serious threat for mental well-being, especially for individuals with severe mental illnesses. Discontinued outpatient treatments and a disruption of daily routines are considered to be a risk factor for destabilization of mentally ill patients. Read More

View Article and Full-Text PDF

Face-to-face versus Video Teleconference Group Cognitive Behavioural Therapy for Anxiety and Related Disorders: A Preliminary Comparison: Thérapie cognitivo-comportementale de groupe en personne contre par vidéo téléconférence pour l'anxiété et les troubles connexes: une comparaison préliminaire.

Can J Psychiatry 2021 Jun 23:7067437211027319. Epub 2021 Jun 23.

Anxiety Treatment and Research Clinic, 25479St. Joseph's Healthcare, Hamilton, Ontario, Canada.

Objective: Telehealth is being increasingly incorporated into the delivery of mental health care and has received widespread attention during the COVID-19 pandemic for its ability to facilitate care during physical distancing restrictions. Videoconferencing is a common telehealth modality for delivering psychotherapy and has demonstrated similar outcomes to those of face-to-face therapy. Cognitive behavioural therapy (CBT) is the most common psychotherapy evaluated across various telehealth modalities; however, studies on CBT delivered via videoconference, particularly in a group therapy format, are lacking. Read More

View Article and Full-Text PDF

Decreased Nucleus Accumbens Connectivity at Rest in Medication-Free Patients with Obsessive-Compulsive Disorder.

Neural Plast 2021 1;2021:9966378. Epub 2021 Jun 1.

Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.

Background: Patients with obsessive-compulsive disorder (OCD) experience deficiencies in reward processing. The investigation of the reward circuit and its essential connectivity may further clarify the pathogenesis of OCD.

Methods: The current research was designed to analyze the nucleus accumbens (NAc) functional connectivity at rest in medicine-free patients with OCD. Read More

View Article and Full-Text PDF

Role of comorbid depressive symptoms on the cognitive deficits in obsessive compulsive disorder.

Ind Psychiatry J 2020 Jul-Dec;29(2):302-309. Epub 2021 Mar 15.

Department of Psychiatry, Institute of Psychiatry-A Centre of Excellence, Kolkata, West Bengal, India.

Background: Obsessive compulsive disorder (OCD) is a chronic distressing condition that is marked with impairment in daily functioning including social, family, and occupational areas of life. Depression is the most common comorbidity among patients with OCD. The presence of co-occurring depressive symptoms adds to the burden of the OCD. Read More

View Article and Full-Text PDF

Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.

Mol Psychiatry 2021 Jun 22. Epub 2021 Jun 22.

Department of Molecular Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, 265 Campus Dr., Stanford, CA, 94305, USA.

Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are expressed in distinct subsets of neurons throughout the brain. Cbln1 and Cbln2 simultaneously bind to presynaptic neurexins and postsynaptic GluD1 and GluD2, thereby forming trans-synaptic adhesion complexes. Genetic associations link cerebellins, neurexins and GluD's to neuropsychiatric disorders involving compulsive behaviors, such as Tourette syndrome, attention-deficit hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD). Read More

View Article and Full-Text PDF

Identification of biomarkers that predict response to subthalamic nucleus deep brain stimulation in resistant obsessive-compulsive disorder: protocol for an open-label follow-up study.

BMJ Open 2021 Jun 22;11(6):e047492. Epub 2021 Jun 22.

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

Introduction: Deep brain stimulation (DBS) of bilateral anteromedial subthalamic nucleus (amSTN) has been found to be helpful in a subset of patients with severe, chronic and treatment-refractory obsessive-compulsive disorder (OCD). Biomarkers may aid in patient selection and optimisation of this invasive treatment. In this trial, we intend to evaluate neurocognitive function related to STN and related biosignatures as potential biomarkers for STN DBS in OCD. Read More

View Article and Full-Text PDF

Altered fronto-amygdalar functional connectivity predicts response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder.

Depress Anxiety 2021 Jun 22. Epub 2021 Jun 22.

Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, New York, USA.

Background: Based on findings from adults with obsessive-compulsive disorder (OCD), this study examined alterations in resting-state functional connectivity (rs-fc) between the basolateral amygdala (BLA) and the ventromedial prefrontal cortex (vmPFC) in children and adolescents with OCD. We also assessed whether such BLA-vmPFC connectivity changed with or predicted response to exposure and response prevention (E/RP), the first-line treatment for pediatric OCD, given the involvement of these regions in fear processing, regulation, and extinction learning-a probable mechanism of action of E/RP.

Methods: Resting state functional magnetic resonance imaging scans were acquired from 25 unmedicated, treatment-naïve pediatric patients with OCD (12. Read More

View Article and Full-Text PDF

Management of Obsessive-Compulsive Disorder before Bariatric Surgery with Cognitive Behavioral Therapy During COVID-19.

Obes Surg 2021 Jun 22. Epub 2021 Jun 22.

University of Al-Ameed, Karbala, Iraq.

This is a report about a 44-year-old woman, with morbid obesity (BMI = 43) who was a candidate for bariatric surgery (BS) in Mother and Child Hospital in Shiraz, Iran. She had obsessive-compulsive disorder (OCD), so she refused surgery because she was afraid of getting the coronavirus. Psychiatric diagnostic interview and EyleBrown questionnaire that consists of 10 items were performed by a psychiatrist for the patient. Read More

View Article and Full-Text PDF

Teachers' Knowledge and Stigmatizing Attitudes Associated With Obsessive-Compulsive Disorder: Effectiveness of a Brief Educational Intervention.

Front Psychiatry 2021 2;12:677567. Epub 2021 Jun 2.

Departamento de Personalidad, Evaluación y Tratamientos Psicológicos, Facultad de Psicología, Universitat de València, Valencia, Spain.

Because children and adolescents are vulnerable to developing obsessive-compulsive disorder (OCD), classroom teachers play an important role in the early identification and intervention in students with OCD. The present study aims to explore the recognition of OCD, general knowledge about this disorder, implications in the classroom, and stigmatizing attitudes among teachers, as well as the effectiveness of a brief educational intervention about OCD. Participants ( = 95; mean age = 43. Read More

View Article and Full-Text PDF

Rare Opportunities for Insights Into Serotonergic Contributions to Brain and Bowel Disorders: Studies of the SERT Ala56 Mouse.

Front Cell Neurosci 2021 3;15:677563. Epub 2021 Jun 3.

Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, United States.

Altered structure, expression, and regulation of the presynaptic serotonin (5-HT) transporter (SERT) have been associated with multiple neurobehavioral disorders, including mood disorders, obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). Opportunities to investigate mechanistic links supporting these associations were spurred with the identification of multiple, rare human SERT coding variants in a study that established a male-specific linkage of ASD to a linkage marker on chromosome 17 which encompassed the location of the SERT gene (). We have explored the most common of these variants, SERT Ala56, and . Read More

View Article and Full-Text PDF

Behavioral features in Prader-Willi syndrome (PWS): consensus paper from the International PWS Clinical Trial Consortium.

J Neurodev Disord 2021 Jun 21;13(1):25. Epub 2021 Jun 21.

Centre for Applied Psychology, School of Psychology, University of Birmingham, Edgbaston, Birmingham, UK.

Prader-Willi syndrome (PWS) is a rare neurodevelopmental genetic disorder associated with a characteristic behavioral phenotype that includes severe hyperphagia and a variety of other behavioral challenges such as temper outbursts and anxiety. These behaviors have a significant and dramatic impact on the daily functioning and quality of life for the person with PWS and their families. To date, effective therapies addressing these behavioral challenges have proven elusive, but several potential treatments are on the horizon. Read More

View Article and Full-Text PDF

Specialized psychiatric services: patient characteristics, referral practice and length of stay in a representative clinical sample 2010-2016.

Int J Dev Disabil 2018 Mar 15;65(4):277-284. Epub 2018 Mar 15.

Oslo University Hospital, Dikemark, Asker, Norway.

Background: Mental health services for patients intellectual disabilities (ID) and additional mental illnesses are only sparsely studied.

Objective: The objective was to describe a representative sample of patients with ID in a specialized psychiatric department.

Methods: Data were collected from case files in a 7-year period. Read More

View Article and Full-Text PDF

The Contribution of Anxiety Sensitivity to Obsessive-Compulsive and Anxiety Symptoms in a Naturalistic Treatment Setting.

Cognit Ther Res 2018 Oct 30;42(5):661-673. Epub 2018 Mar 30.

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.

Anxiety sensitivity, a fear of arousal-related sensations, is prevalent in a number of disorders. We examined the relationship between internalizing symptoms and the anxiety sensitivity components of physical, social, and cognitive concerns in a sample of 165 patients seeking treatment in a clinic specializing in CBT for anxiety-related disorders. Social anxiety symptoms were associated with greater social concerns. Read More

View Article and Full-Text PDF
October 2018

Prevalence and risk factors associated with alcohol consumption among indigenous people in Sabah Borneo Island.

Aust J Rural Health 2021 Jun 20. Epub 2021 Jun 20.

Faculty of Medicine, MAHSA University College, Jalan Universiti, Kuala Lumpur, Malaysia.

Objectives: In this study, we aimed to determine the prevalence and risk factors of alcohol use among a cohort of population in Sabah.

Design: This is a prospective, cohort study involving rural community residents.

Setting: Rural community resident at Bingkor, Keningau, Sabah. Read More

View Article and Full-Text PDF

Homogeneous grey matter patterns in patients with obsessive-compulsive disorder.

Neuroimage Clin 2021 Jun 13;31:102727. Epub 2021 Jun 13.

Department of Neuroradiology & TUM-Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.

Background: Changes in grey matter volume have frequently been reported in patients with obsessive-compulsive disorder (OCD). Most studies performed whole brain or region-of-interest based analyses whereas grey matter volume based on structural covariance networks has barely been investigated up to now. Therefore, the present study investigated grey matter volume within structural covariance networks in a sample of 228 participants (n = 117 OCD patients, n = 111 healthy controls). Read More

View Article and Full-Text PDF

Disrupted functional connectivity of precuneus subregions in obsessive-compulsive disorder.

Neuroimage Clin 2021 Jun 9;31:102720. Epub 2021 Jun 9.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, PR China. Electronic address:

Obsessive-compulsive disorder (OCD) is a chronic and disablingpsychiatric disorder with high lifetime prevalence, yet the underlying pathogenesis remains not fully understood. Increasing neuroimaging evidence has shown that the disrupted activity of brain functional hubs might contribute to the pathophysiology of OCD. Precuneus is an important brain hub which showed structural and functional abnormalities in OCD patients. Read More

View Article and Full-Text PDF

Potential optimization of focused ultrasound capsulotomy for obsessive compulsive disorder.

Brain 2021 Jun 18. Epub 2021 Jun 18.

Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Canada.

Obsessive-compulsive disorder is a debilitating and often refractory psychiatric disorder. Magnetic resonance-guided focused ultrasound is a novel, minimally invasive neuromodulatory technique that has shown promise in treating this condition. We investigated the relationship between lesion location and long-term outcome in obsessive-compulsive disorder patients treated with focused ultrasound to discern the optimal lesion location and elucidate the efficacious network underlying symptom alleviation. Read More

View Article and Full-Text PDF

Comorbid mental disorders during long-term course in a nationwide cohort of patients with anorexia nervosa.

Int J Eat Disord 2021 Jun 18. Epub 2021 Jun 18.

Center for Eating Disorders, Odense University Hospital, Odense, Denmark.

Objective: Comorbid mental disorders in anorexia nervosa during long-term course require detailed studies.

Method: This matched cohort study was based on nationwide Danish register data of all patients born 1961-2008 with a first-time ICD-10 diagnosis of anorexia nervosa (AN) between 1994 and 2018 at age 8-32 and matched controls taken from all individuals without an eating disorder (ED). For nine categories of non-eating mental disorders, time from date of first AN-diagnosis (inclusion date) to time of first diagnosis, accounting for censoring, was studied by use of time-stratified Cox models. Read More

View Article and Full-Text PDF

Blocking Tics in Gilles de la Tourette Syndrome.

Front Neurol 2021 31;12:686785. Epub 2021 May 31.

Department of Neurology, Medical University of Warsaw, Warsaw, Poland.

Patients with Gilles de la Tourette syndrome (GTS) may experience blocking tics (BTs) defined as recurrent, brief cessations of motor acts. The aim of this study was to assess the prevalence, age of onset, and clinical correlates of BTs in GTS patients. We performed a one-time registration study in a cohort of 195 consecutive GTS patients aged 5-66 years (mean age: 15. Read More

View Article and Full-Text PDF

Design and Validation of Augmented Reality Stimuli for the Treatment of Cleaning Obsessive-Compulsive Disorder.

Front Psychol 2021 31;12:618874. Epub 2021 May 31.

Escuela de Psicología, Pontificia Universidad Católica Madre y Maestra, Santiago de los Caballeros, Dominican Republic.

Fear to contamination is an easy-to-provoke, intense, hard-to-control, and extraordinarily persistent fear. A worsening of preexisting psychiatric disorders was observed during the COVID-19 (coronavirus disease 2019) outbreak, and several studies suggest that those with obsessive-compulsive disorder (OCD) may be more affected than any other group of people. In the face of worsening OCD symptoms, there is a need for mental health professionals to provide the support needed not only to treat patients who still report symptoms, but also to improve relapse prevention. Read More

View Article and Full-Text PDF

A Unified Functional Network Target for Deep Brain Stimulation in Obsessive-Compulsive Disorder.

Biol Psychiatry 2021 Apr 20. Epub 2021 Apr 20.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany; Charité - Universitätsmedizin Berlin, Einstein Center for Neurosciences Berlin, Berlin, Germany.

Background: Multiple deep brain stimulation (DBS) targets have been proposed for treating intractable obsessive-compulsive disorder (OCD). Here, we investigated whether stimulation effects of different target sites would be mediated by one common or several segregated functional brain networks.

Methods: First, seeding from active electrodes of 4 OCD patient cohorts (N = 50) receiving DBS to anterior limb of the internal capsule or subthalamic nucleus zones, optimal functional connectivity profiles for maximal Yale-Brown Obsessive Compulsive Scale improvements were calculated and cross-validated in leave-one-cohort-out and leave-one-patient-out designs. Read More

View Article and Full-Text PDF

Irritability in Children and Adolescents With OCD.

Behav Ther 2021 07 12;52(4):883-896. Epub 2020 Nov 12.

Baylor College of Medicine.

Irritability is a common, impairing transdiagnostic symptom in childhood psychopathology, though it has not been comprehensively studied in pediatric obsessive-compulsive disorder (OCD). Further, the central cognitive behavioral treatment component for OCD, exposure and response prevention therapy (ERP), has been recently proposed as a treatment for irritability. This study aimed to evaluate whether certain clinical characteristics are associated with irritability in pediatric OCD and whether irritability reduces following ERP. Read More

View Article and Full-Text PDF

Empirically Defining Treatment Response and Remission in Body Dysmorphic Disorder Using a Short Self-Report Instrument.

Behav Ther 2021 07 24;52(4):821-829. Epub 2020 Oct 24.

Centre for Psychiatry Research, Karolinska Institutet and CAP Research Centre, Stockholm Health Care Services.

Determining response or remission status in body dysmorphic disorder (BDD) usually requires a lengthy interview with a trained clinician. This study sought to establish empirically derived cutoffs to define treatment response and remission in BDD using a brief self-report instrument, the Appearance Anxiety Inventory (AAI). Results from three clinical trials of BDD were pooled to create a sample of 123 individuals who had received cognitive-behavioral therapy for BDD, delivered via the Internet. Read More

View Article and Full-Text PDF

Improving Delivery Behaviors During Exposure for Pediatric OCD: A Multiple Baseline Training Trial With Community Therapists.

Behav Ther 2021 07 24;52(4):806-820. Epub 2020 Oct 24.

Lifespan Biostatistics Core, Lifespan Hospitals; Warren Alpert Medical School of Brown University; University of Rhode Island.

This study tested whether a new training tool, the Exposure Guide (EG), improved in-session therapist behaviors (i.e., indicators of quality) that have been associated with youth outcomes in prior clinical trials of exposure therapy. Read More

View Article and Full-Text PDF

Homework Compliance and Quality in Cognitive Behavioral Therapies for Anxiety Disorders and Obsessive-Compulsive Disorder.

Behav Ther 2021 07 21;52(4):1008-1018. Epub 2021 Jan 21.

Center for Anxiety and Related Disorders at Boston University.

Homework assignments are an integral part of cognitive behavioral therapy, providing patients with opportunities to practice skills between sessions. Generally, greater homework compliance is associated with better treatment outcomes. However, fewer studies have examined the effect of homework quality on treatment outcomes. Read More

View Article and Full-Text PDF

Malondialdehyde concentrations in obsessive-compulsive disorder: a systematic review and meta-analysis.

Ann Gen Psychiatry 2021 Jun 16;20(1):34. Epub 2021 Jun 16.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences (KAUMS), Kashan, Iran.

Background: This meta-analysis aimed to investigate serum and plasma malondialdehyde (MDA) levels in patients with obsessive-compulsive disorder (OCD) in comparison to healthy controls.

Methods: Following the PRISMA protocol, we searched for the relevant studies through the databases of Scopus, PubMed, Google Scholar, and web of science until September 2019 with no time restriction. Overall, nine studies were included in the current meta-analysis. Read More

View Article and Full-Text PDF

Developing a provincial patient support network for children and families affected by Tourette syndrome and/or obsessive-compulsive disorder: results of a stakeholder consultation.

Child Adolesc Psychiatry Ment Health 2021 Jun 16;15(1):29. Epub 2021 Jun 16.

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Background: Tourette syndrome and OCD are disorders that frequently occur in children and cause a high level of disability. In Alberta there is a huge delivery gap in providing healthcare services for children with TS and OCD. A stakeholder consultation was performed to ascertain how service delivery could be improved across the province and to inform the development of a provincial information and support organization, the Tourette OCD Alberta Network. Read More

View Article and Full-Text PDF

Dysregulation profile (DP) as a transdiagnostic psychopathological factor in clinically referred children - comparisons between disorders and latent structure.

Nord J Psychiatry 2021 Jun 15:1-9. Epub 2021 Jun 15.

Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center of Goettingen, Goettingen, Germany.

Background: Dysregulation Profile (DP) describes the psychopathological construct of concurrent impairments in the ability to regulate emotion, behaviour, and cognition measured by the Child Behaviour Checklist (CBCL). Such transdiagnostic dimensions of psychopathology play an important role in addition to core symptoms of psychiatric diagnosis in clinical practice. Evaluation of DP in children with different mental disorders may improve our understanding and treatment of both contents. Read More

View Article and Full-Text PDF

A comparison of phenomenological, clinical and familial psychiatric features of pediatric OCD and trichotillomania.

Int J Psychiatry Clin Pract 2021 Jun 14:1-9. Epub 2021 Jun 14.

Public Health Professional, Osmaniye Community Health Center, Tuberculosis Dispensary, Osmaniye, Turkey.

Objectives: Although trichotillomania (TTM) is classified in the obsessive-compulsive disorders (OCD) chapter of the DSM-5, several studies showed that it has several differences. The aim of this study was to examine the phenomenology, comorbidity, and family psychiatric characteristisc of childhood TTM and OCD.

Methods: This study compared youth ages 6-17 years with a primary diagnosis of TTM ( = 63) to those with primary OCD ( = 65) on clinical and familial psychiatric characteristics. Read More

View Article and Full-Text PDF