18,956 results match your criteria Obsessive-Compulsive Disorder


Parents' Perceptions of Internalizing and Externalizing Features in Childhood OCD.

Child Psychiatry Hum Dev 2019 Feb 18. Epub 2019 Feb 18.

The Geffken Group, 2833 NW 41 St #140, Gainesville, FL, 32606, USA.

Although obsessive-compulsive disorder (OCD) has often been characterized as an internalizing disorder, some children with OCD exhibit externalizing behaviors that are specific to their OCD. This study sought to demonstrate that parents perceive both internalizing and externalizing behaviors in childhood OCD by examining the factor structure of the Child Obsessive-Compulsive Externalizing/Internalizing Scale (COCEIS), a parent-report questionnaire intended to measure these constructs. This study also investigated clinical correlates of internalizing and externalizing factors in the COCEIS. Read More

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http://dx.doi.org/10.1007/s10578-019-00873-wDOI Listing
February 2019

Connectivity Profile Predictive of Effective Deep Brain Stimulation in Obsessive-Compulsive Disorder.

Biol Psychiatry 2019 Jan 9. Epub 2019 Jan 9.

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany; Department of Psychiatry and Psychotherapy, Johanniter Hospital Oberhausen, Oberhausen, Germany.

Background: Deep brain stimulation for obsessive-compulsive disorder is a rapidly developing treatment strategy for treatment-refractory patients. Both the exact target and impact on distributed brain networks remain a matter of debate. Here, we investigated which regions connected to stimulation sites contribute to clinical improvement effects and whether connectivity is able to predict outcomes. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.019DOI Listing
January 2019

Prevalence of Hoarding in an Adult Inpatient Population and Its Association With Axis I Diagnoses.

Am J Geriatr Psychiatry 2018 Dec 28. Epub 2018 Dec 28.

Department of Psychiatry (AB, NG, SP, TJ), Maimonides Medical Center, Brooklyn, NY. Electronic address:

Objective: Hoarding behavior is not limited to obsessive-compulsive disorder (OCD) alone. With the objective of highlighting the association between hoarding behavior and common psychiatric disorders, we explored its occurrence in psychiatric inpatients and co-occurrence with Axis I diagnoses.

Methods: In this prospective cohort study, we enrolled adult psychiatric inpatients by simple random sampling at an urban, community-based, academic medical center. Read More

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http://dx.doi.org/10.1016/j.jagp.2018.12.029DOI Listing
December 2018

Early intervention for obsessive compulsive disorder: An expert consensus statement.

Eur Neuropsychopharmacol 2019 Feb 14. Epub 2019 Feb 14.

Sackler Medical School, Tel Aviv University, Chaim Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel.

Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.02.002DOI Listing
February 2019

Open-label trial of anterior limb of internal capsule-nucleus accumbens deep brain stimulation for obsessive-compulsive disorder: insights gained.

J Neurol Neurosurg Psychiatry 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, Germany.

Background: For more than 15 years, deep brain stimulation (DBS) has served as a last-resort treatment for severe treatment-resistant obsessive-compulsive disorder (OCD).

Methods: From 2010 to 2016, 20 patients with OCD (10 men/10 women) were included in a single-centre trial with a naturalistic open-label design over 1 year to evaluate the effects of DBS in the anterior limb of the internal capsule and nucleus accumbens region (ALIC-NAcc) on OCD symptoms, executive functions, and personality traits.

Results: ALIC-NAcc-DBS significantly decreased OCD symptoms (mean Yale-Brown Obsessive Compulsive Scale reduction 33%, 40% full responders) and improves global functioning without loss of efficacy over 1 year. Read More

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http://dx.doi.org/10.1136/jnnp-2018-318996DOI Listing
February 2019

Neurocognitive assessment in obsessive compulsive disorder patients: Adherence to behavioral decision models.

PLoS One 2019 15;14(2):e0211856. Epub 2019 Feb 15.

Department of Clinical Neurosciences, IRCCS San Raffaele Turro, Milan, Italy.

In economics, models of decision-making under risk are widely investigated. Since many empirical studies have shown patterns in choice behavior that classical models fail to predict, several descriptive theories have been developed. Due to an evident phenotypic heterogeneity, obsessive compulsive disorder (OCD) patients have shown a general deficit in decision making when compared to healthy control subjects (HCs). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211856PLOS
February 2019

Sertraline Effects on Striatal Resting-State Functional Connectivity in Youth With OCD: A Pilot Study.

J Am Acad Child Adolesc Psychiatry 2018 Oct 30. Epub 2018 Oct 30.

University of Minnesota, Minneapolis, MN.

Objective: Foundational knowledge on neural circuitry underlying pediatric obsessive-compulsive disorder (OCD) and how it changes during standard treatment is needed to provide the basis for conceptualization and development of novel, targeted treatments. This study explored the effects of sertraline, a selective serotonin reuptake inhibitor, on resting-state functional connectivity (RSFC) in cortico-striatal-thalamic-cortical circuits in pediatric OCD.

Method: Medication-free youths with OCD (n=14) and healthy controls (n=14) were examined at baseline and 12 weeks with resting-state fMRI. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.07.897DOI Listing
October 2018

Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS.

J Am Acad Child Adolesc Psychiatry 2019 Feb 13. Epub 2019 Feb 13.

Objective: This study evaluates the long-term outcomes of a stepped care treatment for pediatric obsessive-compulsive disorder (OCD) and investigates whether response to first-step cognitive-behavioral therapy (CBT) is an important indicator of three-year outcomes.

Method: This study is a part of the Nordic Long-term OCD Treatment study (NordLOTS), in which 269 children and adolescents were treated with CBT. Non-responders to CBT were randomized to an extended treatment with continued CBT or pharmacotherapy with sertraline. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193010
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http://dx.doi.org/10.1016/j.jaac.2019.01.010DOI Listing
February 2019
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Duration of untreated illness and response to SRI treatment in Obsessive-Compulsive Disorder.

Eur Psychiatry 2019 Feb 11;58:19-26. Epub 2019 Feb 11.

Rita Levi Montalcini Department of Neuroscience, University of Turin, Italy and San Luigi Gonzaga University Hospital, Regione Gonzole 10, 10043, Orbassano, Torino, Italy.

Background: The duration of untreated illness (DUI) is a potentially modifiable parameter associated with worst prognosis in several psychiatric disorders, but poorly investigated in Obsessive-Compulsive Disorder (OCD). Our aims were to estimate the mean DUI in a large sample of individuals with OCD and its impact on response to the first ever adequate SRI treatment.

Methods: We retrospectively examined records of 251 patients with OCD (SCID-I, DSM-IV) who referred to our Department and were prospectively and naturalistically treated according to International Guidelines. Read More

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http://dx.doi.org/10.1016/j.eurpsy.2019.01.017DOI Listing
February 2019

Use of videotaped personal compulsions to enhance motivation in obsessive-compulsive disorder.

BJPsych Open 2019 Jan;5(1):e11

Professor and Psychiatrist,Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry,Amsterdam Public Health and GGZ ingeest,the Netherlands.

Background: Watching videotaped personal compulsions together with a therapist might enhance the effect of cognitive-behavioural therapy in obsessive-compulsive disorder (OCD) but little is known about how patients experience this.AimsTo performed a qualitative study that describes how watching these videos influences motivation for treatment and whether patients report any adverse events.

Method: In this qualitative study, data were gathered in semi-structured interviews with 24 patients with OCD. Read More

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http://dx.doi.org/10.1192/bjo.2018.76DOI Listing
January 2019

Cost-effectiveness analysis of telephone cognitive-behaviour therapy for adolescents with obsessive-compulsive disorder.

BJPsych Open 2019 Jan;5(1):e7

Professor of Health Economics,Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience at King's College London,UK.

Background: Telephone cognitive-behaviour therapy (TCBT) may be a cost-effective method for improving access to evidence-based treatment for obsessive-compulsive disorder (OCD) in young people.AimsEconomic evaluation of TCBT compared with face-to-face CBT for OCD in young people.

Method: Randomised non-inferiority trial comparing TCBT with face-to-face CBT for 72 young people (aged 11 to 18) with a diagnosis of OCD. Read More

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http://dx.doi.org/10.1192/bjo.2018.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343121PMC
January 2019
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The validation of a new online cognitive assessment tool: The MyCognition Quotient.

Int J Methods Psychiatr Res 2019 Feb 13:e1775. Epub 2019 Feb 13.

Department of Psychiatry, Amsterdam University Medical Centers (location AMC), Amsterdam, The Netherlands.

Objectives: Cognitive impairment affects many psychiatric patients, influences daily functioning, and should be an important treatment focus. Assessment of cognitive status is crucial in cognitive remediation studies. However, current test batteries have limitations. Read More

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http://dx.doi.org/10.1002/mpr.1775DOI Listing
February 2019
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3.759 Impact Factor

The role of the Retrospective Identification of Motivations and Inclinations in explaining obsessive beliefs.

Authors:
Gherardo Mannino

Riv Psichiatr 2019 Jan-Feb;54(1):1-7

Department of Mental Health, Azienda Sanitaria Locale Roma 1, Rome, Italy.

While psychopathological phenomena of obsessive-compulsive disorder (OCD) have been well described some time ago, instead there is still need for a deeper understanding of mechanisms underlying psychopathological phenomena themselves. About this, a recently proposed concept - the 'Retrospective Identification of Motivations and Inclinations' (RIMI) - seems to have a promising explanatory capacity about different aspects of obsessive-compulsive disorder. For example, as shown elsewhere, it appears to shed new light on the so-called 'fear of self' in OCD. Read More

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http://dx.doi.org/10.1708/3104.30934DOI Listing
February 2019
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A long-term case study with sadistically-tinged countertransference elements.

Authors:
Douglas H Ingram

Am J Psychoanal 2019 Feb 13. Epub 2019 Feb 13.

, 4 East 89th Street, #1C, New York, NY, 10128, USA.

This case report sketches the psychoanalytically-informed supportive psychotherapeutic treatment of a single man through his life challenges over a twenty-year period. The decades-long challenges arise from obsessive compulsive disorder, pathologic self-effacement with insatiable and unusual erotic components, and severe visual impairment leading to blindness. Sadistically-tinged impulses arising in the countertransference are described. Read More

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http://dx.doi.org/10.1057/s11231-019-09175-5DOI Listing
February 2019

The Origins of Human Functional Stereotaxis: A Reappraisal.

Stereotact Funct Neurosurg 2019 Feb 13:1-6. Epub 2019 Feb 13.

Department of Neurosurgery, Medical School Hannover, Hannover, Germany.

In order to shed light on the first application of human functional stereotactic neurosurgery, whether it was in the realm of movement disorders, as has been claimed repeatedly, or in the realm of psychiatry, a review of the original scholarly literature was conducted. Tracking and scrutinising original publications by Spiegel and Wycis, the pioneers of human stereotactic neurosurgery, it was found that its origin and the very incentive for its development and first clinical use were to avoid the side effects of frontal leucotomy. The first applications of functional stereotactic neurosurgery were in performing dorsomedial thalamotomies in psychiatric patients; it was only later that the stereotactic technique was applied in patients with chronic pain, movement disorders and epilepsy. Read More

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http://dx.doi.org/10.1159/000496157DOI Listing
February 2019
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Investigating the Spectra constellations of the Hierarchical Taxonomy of Psychopathology (HiTOP) model for personality disorders based on empirical data from a community sample.

Braz J Psychiatry 2019 Feb 7. Epub 2019 Feb 7.

Departamento de Psicologia e Psicanálise, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.

Objective: The Hierarchical Taxonomy of Psychopathology (HiTOP) posits that psychopathology is hierarchically structured. For personality disorder (PD) traits, there are five spectra: internalizing, thought disorder, disinhibited externalizing, antagonistic externalizing, and detachment. Empirical findings suggest a sixth group, compulsivity. Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0015DOI Listing
February 2019
1 Read

Can Brief, Daily Training Using a Mobile App Help Change Maladaptive Beliefs? Crossover Randomized Controlled Trial.

JMIR Mhealth Uhealth 2019 Feb 13;7(2):e11443. Epub 2019 Feb 13.

Baruch Ivcher School of Psychology, Interdisciplinary Center Herzliya, Herzliya, Israel.

Background: Obsessive-compulsive disorder (OCD) is a disabling condition with a wide variety of clinical presentations including contamination fears, fear of harm, and relationship-related obsessions. Cognitive behavioral models of OCD suggest that OC symptoms result from catastrophic misinterpretations of commonly occurring intrusive experiences and associated dysfunctional strategies used to manage them. OCD-related maladaptive beliefs including inflated responsibility, importance and control of thoughts, perfectionism, and intolerance for uncertainty increase the likelihood of such misinterpretations. Read More

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http://dx.doi.org/10.2196/11443DOI Listing
February 2019

Changes of motor cortical excitability and response inhibition in patients with obsessive–compulsive disorder

J Psychiatry Neurosci 2019 Feb 13;44(2):1-8. Epub 2019 Feb 13.

From the Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea (Kang, C. Kim, S.J. Kim); the Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, South Korea (D.Y. Kim); and the Yonsei Phil Neuropsychiatric Clinic, Seoul, South Korea (Lee).

Background: Deficits in cortical inhibitory processes have been suggested as underlying pathophysiological mechanisms of obsessive–compulsive disorder (OCD). We examined whether patients with OCD have altered cortical excitability using paired-pulse transcranial magnetic stimulation (TMS). We also tested associations between TMS indices and OCD-related characteristics, including age of onset and response inhibition in the go/no-go paradigm, to examine whether altered cortical excitability contributes to symptom formation and behavioural inhibition deficit in patients with OCD. Read More

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http://dx.doi.org/10.1503/jpn.180064DOI Listing
February 2019
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Using Twitter to Detect Psychological Characteristics of Self-Identified Persons With Autism Spectrum Disorder: A Feasibility Study.

JMIR Mhealth Uhealth 2019 Feb 12;7(2):e12264. Epub 2019 Feb 12.

Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, United States.

Background: More than 3.5 million Americans live with autism spectrum disorder (ASD). Major challenges persist in diagnosing ASD as no medical test exists to diagnose this disorder. Read More

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http://dx.doi.org/10.2196/12264DOI Listing
February 2019
1 Read

Long-Term Follow-up of Patients with Tourette's Syndrome.

Mov Disord Clin Pract 2019 Jan 16;6(1):40-45. Epub 2018 Nov 16.

Department of Psychiatry University of California San Francisco San Francisco CA USA.

Background: Tourette's Syndrome (TS) is a childhood-onset movement disorder marked by the chronic presence of motor and vocal tics. Research shows that tics associated with TS tend to fade in severity for some (but not all) affected youth, though psychiatric comorbidities that commonly accompany TS may be more persistent. The long-term outcomes of individuals with TS have not been well characterized. Read More

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http://dx.doi.org/10.1002/mdc3.12696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335508PMC
January 2019
1 Read

Obsessive-compulsive disorder comorbid with schizophrenia and bipolar disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S140-S148

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Obsessive Compulsive Disorder (OCD) and Obsessive Compulsive Symptoms (OCS) are known to be highly comorbid with bipolar disorder and schizophrenia. Comorbid OCD/OCS influences the course of schizophrenia and bipolar disorder. There is also some evidence to suggest that a diagnosis of OCD may be associated with elevated risk for later development of psychosis and bipolar disorder. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_527_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343407PMC
January 2019
1 Read

Trichotillomania (hair pulling disorder).

Authors:
Jon E Grant

Indian J Psychiatry 2019 Jan;61(Suppl 1):S136-S139

Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.

Trichotillomania is characterized by the repetitive pulling out of one's own hair leading to hair loss and possibly functional impairment. Trichotillomania has been documented in the medical literature since the 19 century. Prevalence studies suggest that trichotillomania is a common disorder (point prevalence estimates of 0. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_529_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343418PMC
January 2019
1 Read

Challenges in the diagnosis and treatment of pediatric obsessive-compulsive disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S119-S130

Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Obsessive-compulsive disorder (OCD) affects 1%-3% of children worldwide and has a profound impact on quality of life for patients and families. Although our understanding of the underlying etiology remains limited, data from neuroimaging and genetic studies as well as the efficacy of serotonergic medications suggest the disorder is associated with the fundamental alterations in the function of cortico-striato-thalamocortical circuits. Significant delays to diagnosis are common, ultimately leading to more severe functional impairment with long-term developmental consequences. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_524_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343419PMC
January 2019
1 Read

The role of personality disorders in obsessive-compulsive disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S114-S118

Senior Consultant Psychiatrist, New Delhi & Formerly Additional Professor of Psychiatry and Head, OCD Clinic, NIMHANS, Bangalore, Karnataka, India.

Personality disorders are a common comorbidity in obsessive-compulsive disorder (OCD). The effect of comorbidity on the symptom presentation, course, and treatment outcome of OCD is being discussed here. OCD and obsessive-compulsive personality disorder (OCPD) though similar in their symptom presentation, are distinct constructs. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_526_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343421PMC
January 2019
1 Read

New-wave behavioral therapies in obsessive-compulsive disorder: Moving toward integrated behavioral therapies.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S104-S113

Department of Clinical Psychology, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.

New-wave behavioral therapies in obsessive-compulsive disorders (OCDs) comprise of third-wave therapies and newer cognitive therapies (CTs). This review covers outcome studies published in English until December 2017. A total of forty articles on mindfulness-based CT, metacognitive therapy, acceptance and commitment therapy, and danger ideation reduction therapy in the form of single-case studies, case series, open-label trials, two-group comparison studies, and randomized controlled studies were included. Read More

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http://www.indianjpsychiatry.org/text.asp?2019/61/7/104/2496
Publisher Site
http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_531_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343420PMC
January 2019
4 Reads

Family accommodation in psychopathology: A synthesized review.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S93-S103

Yale University Child Study Center, New Haven, CT, USA.

Family accommodation describes changes that family members make to their own behavior, to help their relative who is dealing with psychopathology, and to avoid or alleviate distress related to the disorder. Research on family accommodation has expanded greatly in the past few years. The aim of this study was to provide a synthesized review of recent findings on family accommodation in psychopathology. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_530_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343404PMC
January 2019
1 Read

Exposure and response prevention for obsessive-compulsive disorder: A review and new directions.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S85-S92

Anxiety Disorders Clinic, New York State Psychiatric Institute, Columbia University, New York, NY, USA.

Obsessive-compulsive disorder (OCD) is characterized by distressing thoughts and repetitive behaviors that are interfering, time-consuming, and difficult to control. Although OCD was once thought to be untreatable, the last few decades have seen great success in reducing symptoms with exposure and response prevention (ERP), which is now considered to be the first-line psychotherapy for the disorder. Despite these significant therapeutic advances, there remain a number of challenges in treating OCD. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_516_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343408PMC
January 2019

Ablative neurosurgery and deep brain stimulation for obsessive-compulsive disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S77-S84

Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Despite advancements in pharmacotherapeutic and behavioral interventions, a substantial proportion of patients with obsessive-compulsive disorder (OCD) continue to have disabling and treatment-refractory illness. Neurosurgical interventions, including ablative procedures and deep brain stimulation (DBS), have emerged as potential treatment options in this population. We review the recent literature on contemporary surgical options for OCD, focusing on clinical aspects such as patient selection, presurgical assessment, and safety and effectiveness of these procedures. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_523_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343416PMC
January 2019
1 Read

Noninvasive brain stimulation in obsessive-compulsive disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S66-S76

Department of Psychiatry, WISER Neuromodulation Program, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Obsessive-compulsive disorder (OCD) is a complex neuropsychiatric disorder with a chronic course, contributing to significant socio-occupational dysfunction. Forty percent of patients remain treatment refractive despite mainstream treatment options such as serotonin-reuptake inhibitors and cognitive behavior therapy. Noninvasive brain stimulation approaches such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have piqued interest as add-on treatment options in OCD. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_522_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343411PMC
January 2019
1 Read

Glutamatergic augmentation strategies in obsessive-compulsive disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S58-S65

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Proven treatment strategies for obsessive-compulsive disorder (OCD) include pharmacotherapy with serotonin reuptake inhibitors and cognitive behavior therapy (CBT). A significant proportion of patients (25%-30%) fail to respond to these treatment options, necessitating the need for additional treatment options to improve treatment outcomes and quality of life in patients with OCD. Augmentation strategies using various glutamatergic agents have been explored, with diverse outcomes. Read More

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http://www.indianjpsychiatry.org/text.asp?2019/61/7/58/24968
Publisher Site
http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_520_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343415PMC
January 2019
2 Reads

Antipsychotic augmentation in the treatment of obsessive-compulsive disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S51-S57

Department of Psychiatry, OCD Clinic, NIMHANS, Bengaluru, Karnataka, India.

Most studies suggest that obsessive-compulsive disorder runs a chronic course. Only 40%-70% of patients respond to first-line treatment with selective serotonin reuptake inhibitors (SSRIs). The most common pharmacological strategy used in clinical practice for partial responders to SSRIs is augmentation with an atypical antipsychotic. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_519_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343405PMC
January 2019

Course and outcome of obsessive-compulsive disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S43-S50

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Obsessive-compulsive disorder (OCD) is generally believed to follow a chronic waxing and waning course. The onset of illness has a bimodal peak - in early adolescence and in early adulthood. Consultation and initiation of treatment are often delayed for several years. Read More

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http://www.indianjpsychiatry.org/text.asp?2019/61/7/43/24968
Publisher Site
http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_521_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343417PMC
January 2019
2 Reads

Genetics of obsessive-compulsive disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S37-S42

Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.

Obsessive-compulsive disorder (OCD) has been seen to run in families and genetics help to understand its heritability. In this review, we summarize older studies which focused on establishing the familial nature of OCD, including its various dimensions of symptoms, and we focus on recent findings from studies using both the candidate gene approach and genome-wide association study (GWAS) approach. The family studies and twin studies establish the heritability of OCD. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_518_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343406PMC
January 2019

Neurocognitive deficits in obsessive-compulsive disorder: A selective review.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S30-S36

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Obsessive-compulsive disorder (OCD) is a debilitating mental illness characterized by an early onset and chronic course. Evidence from several lines of research suggests significant neuropsychological deficits in patients with OCD; executive dysfunction and nonverbal memory deficits have been reported consistently in OCD. These deficits persist despite controlling potential confounders such as comorbidity, severity of illness, and medications. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_517_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343403PMC
January 2019
1 Read

Neuroimaging findings in obsessive-compulsive disorder: A narrative review to elucidate neurobiological underpinnings.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S9-S29

Department of Psychiatry, OCD Clinic, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Obsessive compulsive disorder (OCD) is a common psychiatric illness and significant research has been ongoing to understand its neurobiological basis. Neuroimaging studies right from the 1980s have revealed significant differences between OCD patients and healthy controls. Initial imaging findings showing hyperactivity in the prefrontal cortex (mainly orbitofrontal cortex), anterior cingulate cortex and caudate nucleus led to the postulation of the cortico-striato-thalamo-cortical (CSTC) model for the neurobiology of OCD. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_525_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343409PMC
January 2019
1 Read

Obsessive-compulsive disorder and global mental health.

Authors:
Dan J Stein

Indian J Psychiatry 2019 Jan;61(Suppl 1):S4-S8

SA MRC Research Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, South Africa.

The discipline of global mental health has emphasized the importance of the treatment gap in mental disorders, and of addressing this gap via changes in health policy, an emphasis on human rights, and innovations such as task-shifting. Although global mental health research has focused on both common mental disorders such as depression, and serious mental disorders such as schizophrenia, it has paid relatively little attention to obsessive-compulsive and related disorders (OCRDs). Nevertheless, international collaborations have recently paid a good deal of attention to the nosology and neurobiology of OCRDs, and given the prevalence and morbidity of these conditions, further work along these lines should be encouraged. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_515_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343414PMC
January 2019
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Obsessive-compulsive disorder: Mimicking journey of psychiatry.

Authors:
Om Prakash Singh

Indian J Psychiatry 2019 Jan;61(Suppl 1):S1

Professor of Psychiatry, WBMES and Consultant Psychiatrist, AMRI Hospitals, Kolkata, West Bengal, India.

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_3_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343410PMC
January 2019

Indian guidelines on neurosurgical interventions in psychiatric disorders.

Indian J Psychiatry 2019 Jan-Feb;61(1):13-21

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Neurosurgery for psychiatric disorders (NPD) has been practiced for >80 years. However, the interests have waxed and waned, from 1000s of surgeries in 1940-1950s to handful of surgery in 60-80s. This changed with the application of deep brain stimulation surgery, a surgery, considered to be "reversible" there has been a resurgence in interest. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_536_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341921PMC
February 2019
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Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder.

Psychol Med 2019 Feb 12:1-11. Epub 2019 Feb 12.

Department of Psychology,Humboldt-Universität zu Berlin,Berlin,Germany.

Background: Increased neural error-signals have been observed in obsessive-compulsive disorder (OCD), anxiety disorders, and inconsistently in depression. Reduced neural error-signals have been observed in substance use disorders (SUD). Thus, alterations in error-monitoring are proposed as a transdiagnostic endophenotype. Read More

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http://dx.doi.org/10.1017/S0033291719000199DOI Listing
February 2019

Aripiprazole augmentation in treating comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review.

J Affect Disord 2019 Feb 6;249:15-19. Epub 2019 Feb 6.

Mood Disorders Program, Tufts Medical Center, Boston, MA, USA; Department of Psychiatry, Tufts University Medical School, Boston, MA, USA. Electronic address:

Background: Apparent comorbidity between bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is a common condition in psychiatry, but treatment of BD-OCD remains a clinical challenge. Although serotonin reuptake inhibitors (SRIs) are the first line treatment for OCD, they can induce mood instability in BD. An optimal treatment approach remains to be defined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183291
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http://dx.doi.org/10.1016/j.jad.2019.02.024DOI Listing
February 2019
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Obsessive-Compulsive Symptomatology in Community Youth: Typical Development or a Red Flag for Psychopathology?

J Am Acad Child Adolesc Psychiatry 2019 Feb 24;58(2):277-286.e4. Epub 2018 Nov 24.

Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, and the Neuropsychiatry Section of the Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Objective: Obsessive-compulsive symptoms (OCS) are common throughout development and often considered developmentally appropriate. We evaluated the prevalence and phenotypic heterogeneity of self-reported OCS in a large community youth sample not ascertained for seeking mental-health help. We aimed to identify patterns in OCS that are associated with serious psychopathology and may thus represent a "red flag" that merits psychiatric evaluation. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.06.038DOI Listing
February 2019
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Meta-Review: Network Meta-Analyses in Child and Adolescent Psychiatry.

J Am Acad Child Adolesc Psychiatry 2019 Feb 16;58(2):167-179. Epub 2018 Oct 16.

Warneford Hospital and Oxford Health NHS Foundation Trust, University of Oxford, UK.

Objective: Network meta-analyses (NMAs) are gaining traction as the preferred method for evidence synthesis of intervention studies. This review aimed to summarize the basics of NMAs and conduct a meta-review of available NMAs on the treatment of child and adolescent psychiatric disorders by appraising their quality.

Method: PubMed (Medline), PsycInfo, Embase, Ovid Medline, and Web of Knowledge were systematically searched (last update January 9, 2018). Read More

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http://dx.doi.org/10.1016/j.jaac.2018.07.891DOI Listing
February 2019
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Dynamics in schizo-obsessive spectrum disorders: a computational approach.

J Theor Biol 2019 Feb 6. Epub 2019 Feb 6.

Department of Mathematical Analysis, Budapest University of Technology and Economics, Budapest, Hungary.

The co-morbidity of obsessive-compulsive disorder (OCD) and schizophrenia is higher than what would be expected by chance and the common underlying neuropathophysiology is not well understood. Repetitive stereotypes and routines can be caused by perseverative thoughts and motor sequences in both of these disorders. We extended a previously published computational model to investigate cortico-striatal network dynamics. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.01.038DOI Listing
February 2019
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Strengthened inputs from secondary motor cortex to striatum in a mouse model of compulsive behavior.

J Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA

Hyperactivity in striatum is associated with compulsive behaviors in Obsessive-Compulsive Disorder (OCD) and related illnesses, but it is unclear if this hyperactivity is due to intrinsic striatal dysfunction or abnormalities in corticostriatal inputs. Understanding the cellular and circuit properties underlying striatal hyperactivity could help inform the optimization of targeted stimulation treatments for compulsive behavior disorders. To investigate the cellular and synaptic abnormalities that may underlie corticostriatal dysfunction relevant to OCD, we utilized the Sapap3 knockout (Sapap3-KO) mouse model of compulsive behaviors, which also exhibits hyperactivity in central striatum. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1728-18.2018DOI Listing
February 2019
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Insomnia late in pregnancy is associated with perinatal anxiety: A longitudinal cohort study.

J Affect Disord 2019 Apr 28;248:155-165. Epub 2019 Jan 28.

HØKH, Research Unit, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Lørenskog, Norway; Department for Infant Mental Health, Regional Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway.

Background: Postpartum anxiety (PPA) affects a substantial number of women. Despite increasing recognition of PPA, few studies have focused on perinatal anxiety and potential PPA triggers. Here we aimed to estimate the prevalence of perinatal anxiety disorders, and to explore the association between insomnia during late pregnancy and anxiety before and after childbirth. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.027DOI Listing
April 2019
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The role of basal ganglia neurocircuitry in the pathology of psychiatric disorders.

Psychiatry Clin Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Osaka, Japan.

Over the last few decades, advances in human and animal-based techniques have greatly enhanced our understanding of the neural mechanisms underlying psychiatric disorders. Many of these studies have indicated connectivity between and alterations within basal ganglia structures to be particularly pertinent to the development of symptoms associated with several of these disorders. Here we summarize the connectivity, molecular composition, and function of sites within basal ganglia neurocircuits. Read More

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http://dx.doi.org/10.1111/pcn.12830DOI Listing
February 2019
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Rituals and preoccupations associated with bulimia nervosa in adolescents: Does motivation to change matter?

Eur Eat Disord Rev 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychiatry, University of California, San Francisco, CA, USA.

This study evaluated the effects of two treatments for adolescent bulimia nervosa (BN), family-based treatment (FBT-BN), and cognitive behavioral therapy (CBT-A), on both attitudinal and behavioural outcomes at end-of-treatment. These associations were examined specifically relative to motivation for change in obsessive-compulsive (OC) features of eating disorder (ED) symptoms. Adolescents (N = 110) were randomly assigned to FBT-BN or CBT-A and completed assessments of eating pathology and OC-ED behaviour. Read More

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http://dx.doi.org/10.1002/erv.2664DOI Listing
February 2019
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Corticostriatal-limbic correlates of sub-clinical obsessive-compulsive traits.

Psychiatry Res Neuroimaging 2019 Jan 30;285:40-46. Epub 2019 Jan 30.

Organization for Promotion of Neurodevelopmental Disorder Research, Kyoto, Japan; Faculty of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Obsessive-compulsive (OC) traits such as intrusive worrisome ideas or excessive concerns for threats are frequent in general population (5%-13%). However, the structural neural correlates of the sub-clinical OC traits remain largely unknown. Based on the data of obsessive-compulsive disorder (OCD), we hypothesized that the subcortical and cortical structures, constituting the cortico-striatal-thalamo-cortical circuit (CSTC) and the limbic system, could be associated with OC traits. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.012DOI Listing
January 2019
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