19,664 results match your criteria Obsessive-Compulsive Disorder


Orthorexia nervosa: A behavioral complex or a psychological condition?

J Behav Addict 2018 Dec 17:1-14. Epub 2018 Dec 17.

1 Psychotherapy and Systems Neuroscience, Justus-Liebig-University Giessen , Giessen, Germany.

Background And Aims: Numerous studies have provided evidence for orthorexia nervosa (ON), an eating pattern characterized by an almost manic obsession for and fixation on healthy eating, to be of epidemiological relevance. However, there is scientific debate on whether it is merely a behavioral or lifestyle phenomenon as compared to a mental disorder. Aim of this cross-sectional study was to explore whether ON is of epidemiological and clinical relevance, and whether ON can be distinguished from other mental health disorders and healthy lifestyle features. Read More

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December 2018

[The clinical assessment of obsessive-compulsive symptoms in children and adolescents - A study with the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS-D)].

Z Kinder Jugendpsychiatr Psychother 2018 Dec 17:1-15. Epub 2018 Dec 17.

1 Ausbildungsinstitut für Kinder- und Jugendlichenpsychotherapie (AKiP), Klinikum der Universität zu Köln, Köln.

The clinical assessment of obsessive-compulsive symptoms in children and adolescents - A study with the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS-D) Abstract.

Objective: The CY-BOCS is internationally the most widely used instrument for the assessment of juvenile obsessive-compulsive disorder (OCD). In this study, for the first time, the psychometric properties of a German version of the CY-BOCS (CY-BOCS-D) are examined in a pediatric OCD sample (n = 169; age 11-18 years). Read More

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December 2018

Crossed obsessive-compulsive personality disorder and impaired theory of mind in temporal lobe epilepsy.

Neurol Sci 2018 Dec 15. Epub 2018 Dec 15.

Department of Diagnostics and Applied Technology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.

People with epilepsy often suffer psychiatric symptoms or exhibit maladaptive personality characteristics which can impact them more than seizures. This case illustrates a selective association of a Theory of Mind dysfunction, including an impaired comparison of reality and others' behavior, with an obsessive-compulsive personality disorder in a patient with left temporal lobe epilepsy and crossed cognitive functions. The patient revealed visual memory deficits and impaired interpretation of other people's behavior, mental rigidity, and a tendency to formulate inflexible judgements. Read More

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December 2018

Does obtaining CYP2D6 and CYP2C19 pharmacogenetic testing predict antidepressant response or adverse drug reactions?

Psychiatry Res 2018 Dec 8;271:604-613. Epub 2018 Dec 8.

Harvard South Shore Psychiatry Residency Training Program, Brockton, MA, USA; Department of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Treatment non-response and adverse reactions are common in patients receiving antidepressants. Personalizing psychiatric treatment based on pharmacogenetic testing has been proposed to help clinicians guide antidepressant selection and dosing. This systematic literature review assesses the two most robustly studied drug-metabolizing enzymes, CYP2D6 and CYP2C19, and examines whether obtaining CYP2D6 and CYP2C19 testing can be used to predict antidepressant response or adverse drug reactions in order to improve clinical outcomes. Read More

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December 2018

Public stigma of obsessive compulsive disorder and schizophrenic disorder: Is there really any difference?

Psychiatry Res 2018 Dec 10;271:559-564. Epub 2018 Dec 10.

Department of Psychology, Faculty of Arts, Dokuz Eylül University, Buca, İzmir, Turkey.

A substantial delay for help-seeking is a serious problem for people with obsessive-compulsive disorder (OCD), a heterogeneous and debilitating mental health condition. Stigma is a major barrier to treatment seeking and further cause social and occupational impairment. Lack of comprehensive research led us to examine the public's stigmatizing attitudes towards checking, contamination, sexuality, aggression, and religion-related OCD symptoms, compared to schizophrenia. Read More

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December 2018

Genetic variability in the serotoninergic system and age of onset in anorexia nervosa and obsessive-compulsive disorder.

Psychiatry Res 2018 Dec 6;271:554-558. Epub 2018 Dec 6.

Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, C/ Villarroel 170, E-08036 Barcelona, Spain; Department of Medicine, University of Barcelona, Barcelona, Spain; The August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Spain. Electronic address:

The age of onset of some psychiatric disorders may have etiopathogenic and clinical effects and may influence outcome. Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset. One hundred and sixteen adolescents diagnosed with AN and 74 adolescents diagnosed with OCD participated in the present study. Read More

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December 2018

Prevalence and clinical correlations of obsessive-compulsive symptoms in schizophrenia.

Asian J Psychiatr 2018 Nov 27;39:48-52. Epub 2018 Nov 27.

Department of Psychiatry, Centre of Excellence in Mental Health, PGIMER Dr RML Hospital, New Delhi, India. Electronic address:

Introduction: Obsessive compulsive symptoms are often present in persons with schizophrenia. Adequately powered studies to evaluate the effect of such symptoms in the course of the disorder, are few.

Aim: We aimed to estimate the prevalence and type of obsessive-compulsive symptoms in persons with schizophrenia. Read More

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November 2018
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Predictive factors associated with driving under the influence among Brazilian drug-using drivers.

Accid Anal Prev 2018 Dec 12;123:256-262. Epub 2018 Dec 12.

Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Rua Professor Álvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil.

The incidence of driving under the influence of psychoactive substances (DUI) and its recidivism can be curtailed by the proper identification of specific and predictive characteristics among drug users. In this sense, interpersonal violence (IV), psychiatric comorbidity and impulsivity seem to play an important role in DUI engagement according to previous studies. There are, however, limited data originated from low and middle income countries. Read More

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December 2018
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In vivo Preclinical Molecular Imaging of repeated exposure to an NMDA antagonist and a glutaminase inhibitor as potential glutamatergic modulators.

J Pharmacol Exp Ther 2018 Dec 14. Epub 2018 Dec 14.

Molecular Imaging Center Antwerp;

Glutamate is the principal excitatory neurotransmitter in the brain and at the base of a wide variety of neuropathologies, including epilepsy, autism, Fragile X and obsessive compulsive disorder. Glutamate has so become the target for novel drugs in treatment and in fundamental research settings. However, much remains unknown on the working mechanisms of these drugs and the effects of chronic administration on the glutamatergic system. Read More

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December 2018

Reduced fear-of-self is associated with improvement in concerns related to repugnant obsessions in obsessive-compulsive disorder.

Br J Clin Psychol 2018 Dec 12. Epub 2018 Dec 12.

Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Quebec, Canada.

Objective: The potential causal and maintaining role of vulnerable self-themes and beliefs about the self in obsessive-compulsive disorder (OCD) have received increasing attention from cognitive-behavioural theorists. This interest was translated into the development of a self-report measurement of the feared self (the fear of who one might be or become), a construct theoretically and empirically pertinent to unwanted thoughts and impulses in OCD (i.e. Read More

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December 2018

Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Naïve Patients With Obsessive-Compulsive Disorder.

Front Neurosci 2018 28;12:889. Epub 2018 Nov 28.

Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.

Obsessive-compulsive disorder (OCD) patients have difficulty in switching between obsessive thought and compulsive behavior, which may be related to the dysfunction of the salience network (SN). However, little is known about the changes in intra- and inter- intrinsic functional connectivity (iFC) of the SN in patients with OCD. In this study, we parceled the SN into 19 subregions and investigated iFC changes for each of these subregions in 40 drug-naïve patients with OCD and 40 healthy controls (HCs) using seed-based functional connectivity resting-state functional magnetic resonance imaging (rs-fMRI). Read More

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November 2018

Action-Outcome Knowledge Dissociates From Behavior in Obsessive-Compulsive Disorder Following Contingency Degradation.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Oct 9. Epub 2018 Oct 9.

Department of Psychology, University of Cambridge, Cambridge, United Kingdom; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.

Background: In obsessive-compulsive disorder (OCD), actions persist despite being inappropriate to the situation and without relationship to the overall goal. Dysfunctional beliefs have traditionally been postulated to underlie this condition. More recently, OCD has been characterized in terms of an imbalance between the goal-directed and the habit systems. Read More

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October 2018
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Disentangling orthorexia nervosa from healthy eating and other eating disorder symptoms: Relationships with clinical impairment, comorbidity, and self-reported food choices.

Appetite 2018 Dec 10. Epub 2018 Dec 10.

Penn State College of Medicine, Penn State Health Milton S. Hershey Medical Center, United States.

Background: Orthorexia nervosa (ON) is characterized by obsessions about eating healthily and rigid adherence to a perceived healthy diet. This study uses the Eating Habits Questionnaire to investigate the relationship of ON symptoms with self-reported food intake, eating-related impairment, obsessive compulsive disorder symptoms (OCD), gender, and BMI while controlling for other eating disordered symptoms. The aim of this study is to provide further evidence for the construct of ON as distinct from other forms of disordered eating. Read More

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December 2018

Deep brain stimulation for obsessive compulsive disorder: A review of results by anatomical target.

Ment Illn 2018 Nov 6;10(2):7900. Epub 2018 Nov 6.

University of California Irvine, Orange, CA, USA.

Studies suggest deep brain stimulation (DBS) as a treatment modality for the refractory obsessive-compulsive disorder (OCD). It is unclear where to place the DBS. Various sites are proposed for placement with the ventral capsule/ventral striatum (VC/VS) among the most studied. Read More

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November 2018

Problematic overstudying: Studyholism or study addiction?

J Behav Addict 2018 Dec 13:1-4. Epub 2018 Dec 13.

1 Department of Health Sciences, School of Psychology, University of Florence , Florence, Italy.

This commentary addresses Griffiths et al. (2018)'s sixth myth about work addiction. We agree that work addiction could also be spread in the school context, although we propose that problematic overstudying may be more similar to an obsession than to an addiction toward the study. Read More

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December 2018

Individual white matter bundle trajectories are associated with deep brain stimulation response in obsessive-compulsive disorder.

Brain Stimul 2018 Nov 27. Epub 2018 Nov 27.

Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands.

Background: The ventral anterior limb of the internal capsule (vALIC) is a target for deep brain stimulation (DBS) in obsessive-compulsive disorder (OCD). Conventional surgical planning is based on anatomical landmarks.

Objective/hypothesis: We hypothesized that treatment response depends on the location of the active DBS contacts with respect to individual white matter bundle trajectories. Read More

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November 2018

From anatomy to function: the role of the somatosensory cortex in emotional regulation.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.

 : Since the pioneering work of Penfield and his colleagues in the 1930s, the somatosensory cortex, which is located on the postcentral gyrus, has been known for its central role in processing sensory information from various parts of the body. More recently, a converging body of literature has shown that the somatosensory cortex also plays an important role in each stage of emotional processing, including identification of emotional significance in a stimulus, generation of emotional states, and regulation of emotion. Importantly, studies conducted in individuals suffering from mental disorders associated with abnormal emotional regulation, such as major depression, bipolar disorder, schizophrenia, post-traumatic stress disorder, anxiety and panic disorders, specific phobia, obesity, and obsessive-compulsive disorder, have found structural and functional changes in the somatosensory cortex. Read More

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December 2018
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No evidence of attentional bias toward angry faces in patients with obsessive-compulsive disorder.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Objective: Although attentional bias (AB) toward angry faces is well established in patients with anxiety disorders, it is still poorly studied in obsessive-compulsive disorder (OCD). We investigated whether OCD patients present AB toward angry faces, whether AB is related to symptom severity and whether AB scores are associated with specific OCD symptom dimensions.

Method: Forty-eight OCD patients were assessed in clinical evaluations, intelligence testing and a dot-probe AB paradigm that used neutral and angry faces as stimuli. Read More

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December 2018
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Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine.

Eur Arch Psychiatry Clin Neurosci 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany.

Obsessive-compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So far, little is known about possible neural mechanism of these SGAs, which seem to aggravate or induce OCS. Read More

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December 2018
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Suboptimal health status and psychological symptoms among Chinese college students: a perspective of predictive, preventive and personalised health.

EPMA J 2018 Dec 28;9(4):367-377. Epub 2018 Aug 28.

1School of Public Health, Taishan Medical University, 619 Changcheng Road, Taian, 271016 People's Republic of China.

Background: Suboptimal health status (SHS) is an intermediate health status between health and illness, a syndrome characterised by the perception of health complaints, general weakness and low energy. This study aimed to investigate the prevalence of SHS and the correlation between SHS and psychological symptoms among Chinese college students and to identify the SHS-related risk factors from the perspective of predictive, preventive and personalised medicine (PPPM).

Methods: A cross-sectional study was conducted among 4119 college students who were enrolled from Medical University and Vocational and Technical College in the eastern and western areas of China. Read More

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December 2018
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Repetitive Behaviors in Frontotemporal Dementia: Compulsions or Impulsions?

J Neuropsychiatry Clin Neurosci 2018 Dec 12:appineuropsych18060148. Epub 2018 Dec 12.

From the Departments of Neurology (Moheb, Ashla, Mendez) and Psychiatry and Biobehavioral Sciences (Charuworn, Mendez), David Geffen School of Medicine, University of California at Los Angeles; and the Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Los Angeles (Desarzant, Chavez, Mendez).

Objective:: The presence of repetitive behaviors is one of the core criteria for behavioral variant frontotemporal dementia (bvFTD). Patients with bvFTD often have perseverative, stereotyped, or compulsive-ritualistic behavior as an early aspect of their disorder. It is unclear whether such behaviors are related to compulsions, as in obsessive-compulsive disorder (OCD), or are part of the impulse disorder spectrum. Read More

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December 2018

[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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December 2018
3 Reads

Patterns of obsessive-compulsive symptoms and social functioning in schizophrenia; a replication study.

Psychiatry Res 2018 Dec 3;271:421-427. Epub 2018 Dec 3.

Maastricht University Medical Center, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht, the Netherlands; KU Leuven, Department of Neuroscience, Research Group Psychiatry, Leuven, Belgium.

Research has found that Obsessive Compulsive Symptoms (OCS) in schizophrenia are associated with either more or less negative symptoms and either better or poorer cognitive functioning. In order to explain these contradictory results, (Lysaker et al., 2004), performed a cluster analysis resulting in 2 OCS positive (OCSpos) clusters, one with higher functioning (HF) and one with poorer functioning (PF) compared to 2 OCS negative (OCSneg) clusters. Read More

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December 2018
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Object Burying Test for Assessment of Obsessive Compulsive Behaviors in Mice.

Methods Mol Biol 2019 ;1916:81-85

Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia.

Obsessive-compulsive disorder (OCD) can occur in several psychiatric illnesses such as autism spectrum disorders (ASD) and it is more prevalent in children. This condition is characterized by repeated and apparently meaningless behaviors such as frequent hand washing, counting, tapping, and rocking. This can disrupt normal socialization and in some cases lead to self-harm. Read More

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January 2019

Improvement in Obsessive-Compulsive Disorder Following Right Anterior Temporal Lobectomy and Amygdalohippocampectomy in a Patient with Refractory Temporal Lobe Epilepsy with Right Mesial Temporal Sclerosis.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):321-324

Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

There are reports of co-occurrence of obsessive-compulsive disorder (OCD) in patients with temporal lobe epilepsy (TLE). We present a report of a patient with refractory TLE due to hippocampal sclerosis with concomitant OCD on pharmacotherapy for both. She underwent surgery for standard anterior temporal lobectomy with amygdalohippocampectomy and reported improvement in obsessive-compulsive symptoms subsequently. Read More

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December 2018

Identifying disease genes using machine learning and gene functional similarities, assessed through Gene Ontology.

PLoS One 2018 10;13(12):e0208626. Epub 2018 Dec 10.

LASIGE, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.

Identifying disease genes from a vast amount of genetic data is one of the most challenging tasks in the post-genomic era. Also, complex diseases present highly heterogeneous genotype, which difficult biological marker identification. Machine learning methods are widely used to identify these markers, but their performance is highly dependent upon the size and quality of available data. Read More

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December 2018

Exploring Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Extinction Learning-Based Treatment Outcome in Obsessive-Compulsive Disorder: A Pilot Study.

J Clin Psychopharmacol 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA Department of Psychology, Barnard College and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA New York State Psychiatric Institute, New York, NY Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA Department of Psychology, West Virginia University, Morgantown, WV Department of Psychiatry, College of Physicians and Surgeons, Columbia University and New York State Psychiatric InstituteNew York, NY Department of Psychiatry, Weill Cornell Medical College, New York, NY Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA,

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December 2018

The impact of symptom severity on cognitive function in obsessive-compulsive disorder: A meta-analysis.

Clin Psychol Rev 2018 Sep 22. Epub 2018 Sep 22.

Texas State University, San Marcos, TX, USA.

Research on cognitive functions in obsessive-compulsive disorder (OCD) is notoriously heterogeneous with no moderators identified that account for this variability. OCD severity is the primary potential moderator of interest given the longstanding trait versus state debate. Nevertheless, severity has been previously assessed exclusively as a moderator and was not directly and systematically investigated. Read More

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September 2018

Neuro-hemodynamic endophenotypes of emotional interference in OCD: fMRI study using emotion counting stroop task.

Asian J Psychiatr 2018 Nov 24;39:35-41. Epub 2018 Nov 24.

Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, India.

Background: We sought to examine the endophenotype pattern of neuro-hemodynamic substrates of emotion counting Stroop (ecStroop) paradigm in patients with OCD, their unaffected siblings [first degree relatives-FDR] and healthy controls (HC).

Methods: OCD patients (medication naïve)[N = 16], their unaffected siblings(FDR)[N = 16] and HC [N = 24] were compared using an established ecStroop paradigm in a 3-Tesla fMRI. The relative BOLD signals corresponding to the three types of conditions (neural words-N, words with negative emotional salience-E and words with salience for OCD-O) were examined in the apriori hypothesized brain regions. Read More

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November 2018

Examining the factor structure of the self-report Yale-Brown Obsessive Compulsive Scale Symptom Checklist.

Psychiatry Res 2018 Nov 19;271:299-305. Epub 2018 Nov 19.

Amsterdam UMC, Vrije Universiteit, APH-research Institute, Department of Psychiatry and GGZ inGeest, Oldenaller 1, 1081 HJ Amsterdam, The Netherlands.

Obsessive-compulsive symptom dimensions are important in studies about the pathogenesis and treatment of obsessive-compulsive disorder. More than 30 factor analytic studies using the Yale-Brown Obsessive Compulsive Scale Symptom Checklist (Y-BOCS-SC) interview version have been published. However, a drawback of the Y-BOCS-SC interview is that it is time-consuming for the clinician. Read More

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November 2018
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Meta-analysis to derive an empirically based set of personality facet criteria for the alternative DSM-5 model for personality disorders.

Personal Disord 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, University of Otago.

The alternative model for personality disorders (AMPD) is outlined in Section III of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. This model includes 25 dimensional trait facets that are used as criteria for six personality disorders in addition to impairment in functioning. Numerous previous studies have examined the degree to which the proposed trait facets converge with the Section II personality disorders (PDs) they are meant to capture, but the results from these various studies have been inconsistent. Read More

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December 2018
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Living with obsessive-compulsive disorder (OCD): a South African narrative.

Int J Ment Health Syst 2018 1;12:73. Epub 2018 Dec 1.

2SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.

Background: Obsessive-compulsive disorder (OCD) is a highly prevalent and debilitating psychiatric disorder known to interfere with several life domains. Yet little is known about the subjective experiences of living with OCD amongst South Africans and more so, the ways in which it impacts daily functioning and quality of life (QOL).

Methods: The aim of this study was to explore daily functioning and QOL among South African adults living with OCD. Read More

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December 2018
2 Reads

Aripiprazole in acute treatment of children and adolescents with autism spectrum disorder: a systematic review and meta-analysis.

Neuropsychiatr Dis Treat 2018 12;14:3063-3072. Epub 2018 Nov 12.

Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand,

Background: Recent randomized controlled trials indicated that aripiprazole was the effective treatment for children and adolescents with autism spectrum disorder (ASD).

Objective: This study systematically reviewed the efficacy, acceptability and tolerability of aripiprazole in treatment of ASD children and adolescents.

Data Sources: Electronic search of databases including, Scopus, PubMed, CINAHL and Cochrane Controlled Trials Register was performed in July 2017. Read More

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November 2018
2 Reads

Short Versus Long Scales in Clinical Assessment: Exploring the Trade-Off Between Resources Saved and Psychometric Quality Lost Using Two Measures of Obsessive-Compulsive Symptoms.

Assessment 2018 Dec 3:1073191118810057. Epub 2018 Dec 3.

2 Humboldt-Universität zu Berlin, Berlin, Germany.

Short measures of psychological constructs are routinely used to save assessment time and cost. The downside is a trade-off between resource savings and psychometric quality. When evaluating tests, a pragmatic strategy is frequently applied that neglects the assessment objective, which may result in unfair rejection or unmindfully acceptance of short scales. Read More

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December 2018
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Treatment of psychiatric disturbances in common hyperkinetic movement disorders.

Expert Rev Neurother 2018 Dec 1. Epub 2018 Dec 1.

b Department of Human Neurosciences , Sapienza University of Rome , Rome.

Introduction: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's disease and essential tremor. Areas covered: We searched for papers in English in Pubmed using the following keywords: blepharospasm, cervical dystonia, arm dystonia, laryngeal dystonia, spasmodic dysphonia, tic disorders, Tourette syndrome, Huntington's chorea, essential tremor, depression, anxiety, obsessive compulsive disorders, attention deficit hyperactivity disorders, psychosis, apathy. Expert commentary: Although psychiatric disturbances are frequent in hyperkinetic movement disorders, few controlled studies have assessed the treatment of psychiatric disturbances in such disorders. Read More

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December 2018
4 Reads

A Nationwide Study in Denmark of the Association Between Treated Infections and the Subsequent Risk of Treated Mental Disorders in Children and Adolescents.

JAMA Psychiatry 2018 Dec 5. Epub 2018 Dec 5.

Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.

Importance: Infections have been associated with increased risks for mental disorders, such as schizophrenia and depression. However, the association between all infections requiring treatment and the wide range of mental disorders is unknown to date.

Objective: To investigate the association between all treated infections since birth and the subsequent risk of development of any treated mental disorder during childhood and adolescence. Read More

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December 2018
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Effectiveness of Venlafaxine in Selective Serotonin Reuptake Inhibitor-Resistant Obsessive-Compulsive Disorder: Experience From a Specialty Clinic in India.

J Clin Psychopharmacol 2018 Dec 3. Epub 2018 Dec 3.

K.S.Hegde Medical Academy, NITTE, Mangalore, India.

Background: Despite its favorable pharmacological profile and efficacy in major depression and anxiety disorders, evidence for the use of venlafaxine in obsessive-compulsive disorder (OCD) is limited. We sought to examine the real-world effectiveness of venlafaxine from a large database of an OCD clinic in India.

Methods: A total of 1704 consecutive patients who registered at the OCD clinic between June 2014 and December 2016 were evaluated with structured interviews and scales. Read More

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December 2018
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The other side of the coin in renal replacement therapies: the burden on caregivers.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Department of Internal Medicine, Division of Nephrology, School of Medicine, Mersin University, Ciftlikkoy, Yenisehir, Mersin, Turkey.

Purpose: Living with end-stage renal disease may be burdensome, not only for patients, but also for caregivers. In this study, we aim to compare caregiver burden, psychological symptoms in caregivers of peritoneal dialysis (PD), hemodialysis (HD), and transplantation (TX), and find out associated factors.

Methods: A total of 43 PD, 42 HD, 42 TX patients and a total of 127 caregivers that were actively involved with the care of their patients' dialysis were enrolled. Read More

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December 2018
3 Reads

Inferior thalamic peduncle deep brain stimulation for treatment-refractory obsessive-compulsive disorder: A phase 1 pilot trial.

Brain Stimul 2018 Nov 27. Epub 2018 Nov 27.

Division of Neurosurgery, University of Toronto, Canada. Electronic address:

Background: Several different surgical procedures targeting the limbic circuit have been utilized for severe, treatment resistant obsessive-compulsive disorder; however, there has only been limited exploration of the inferior thalamic peduncle (ITP). The aim of this study was to determine the safety and initial efficacy of ITP deep brain stimulation (DBS) in patients with severe obsessive-compulsive disorder.

Methods: Patients with severe, treatment-refractory obsessive-compulsive disorder were enrolled into this open-label phase 1 DBS pilot study. Read More

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November 2018
5 Reads

Functional neural mechanisms of sensory phenomena in obsessive-compulsive disorder.

J Psychiatr Res 2018 Nov 21;109:68-75. Epub 2018 Nov 21.

Department of Psychiatry, New York University School of Medicine, New York, NY, USA; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA. Electronic address:

Sensory phenomena (SP) are aversive or uncomfortable sensations that accompany and/or drive repetitive behaviors in obsessive-compulsive disorder (OCD). Although SP are associated with significant distress and may respond less well to standard treatments than harm-related obsessions, little is known about their underlying neurobiology. The present study used functional magnetic resonance imaging (fMRI) to measure brain functioning related to severity of SP during a "body-focused" videos task designed to elicit activation in sensorimotor brain regions. Read More

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November 2018
1 Read

Transcranial direct current stimulation for the treatment of obsessive-compulsive disorder? A qualitative review of safety and efficacy.

Authors:
Fady Rachid

Psychiatry Res 2018 Nov 16;271:259-264. Epub 2018 Nov 16.

Obsessive-compulsive disorder (OCD) is a highly disabling psychiatric disorder characterized by recurrent obsessions and compulsions. It has a lifetime prevalence of 1-3% in the general population and commonly has a chronic course. First-line treatments consist of selective serotonin reuptake inhibitors and cognitive-behavioral therapy but up to 60% of patients respond partially or not at all to these treatments. Read More

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November 2018
1 Read

Automated Affect Detection in Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Pilot Study.

Proc ACM Int Conf Multimodal Interact 2018 Oct;2018:40-44

Baylor College of Medicine, Houston, Texas.

Automated measurement of affective behavior in psychopathology has been limited primarily to screening and diagnosis. While useful, clinicians more often are concerned with whether patients are improving in response to treatment. Are symptoms abating, is affect becoming more positive, are unanticipated side effects emerging? When treatment includes neural implants, need for objective, repeatable biometrics tied to neurophysiology becomes especially pressing. Read More

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October 2018
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Prevalence of psychiatric disorders in Thai patients with epilepsy.

Epilepsy Behav 2018 Nov 27;90:20-24. Epub 2018 Nov 27.

Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Many studies have shown that the prevalence of psychiatric disorders in patients with epilepsy (PWE) appears higher than that in general population. However, most epidemiological studies regarding psychiatric comorbidities among PWE were conducted in Western countries. This work aimed to determine the prevalence of psychiatric disorders in Thai PWE, including potential variables that could be associated with psychiatric disorders. Read More

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November 2018
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A pilot dose finding study of pioglitazone in autistic children.

Mol Autism 2018 26;9:59. Epub 2018 Nov 26.

1Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, 150 Kilgour Road, Toronto, ON M4G 1R8 Canada.

Background: Pioglitazone is a promising compound for treatment of core autism spectrum disorder (ASD) symptoms as it targets multiple relevant pathways, including immune system alterations.

Objective: This pilot study aimed to elucidate the maximum tolerated dose, safety, preliminary evidence of efficacy, and appropriate outcome measures in autistic children ages 5-12 years old.

Methods: We conducted a 16-week prospective cohort, single blind, single arm, 2-week placebo run-in, dose-finding study of pioglitazone. Read More

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November 2018
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Deep brain stimulation for Gilles de la Tourette syndrome in children and youth: a meta-analysis with individual participant data.

Authors:

J Neurosurg Pediatr 2018 Oct 1:1-11. Epub 2018 Oct 1.

OBJECTIVEGilles de la Tourette syndrome (GTS) is a disorder characterized by motor and vocal tics. Although by definition the onset of GTS is before age 18 years, clinical trials of deep brain stimulation (DBS) have been conducted only in adults. Using individual participant data (IPD) meta-analysis methodology, the current study investigated the safety and efficacy of DBS as a treatment for GTS in children and youth. Read More

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October 2018
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Are punitive parenting and stressful life events environmental risk factors for obsessive-compulsive symptoms in youth? A longitudinal twin study.

Eur Psychiatry 2018 Nov 26;56:35-42. Epub 2018 Nov 26.

King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, De Crespigny Park, London, UK. Electronic address:

Background: Punitive parenting and stressful life events are associated with obsessive-compulsive symptoms (OCS). However, the lack of longitudinal, genetically-informative studies means it remains unclear whether these factors represent environmentally-mediated risks for the development of OCS.

Methods: Twins and siblings from the Genesis1219 study completed self-report questionnaires two years apart (Time 1: N = 2616, mean age = 15. Read More

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November 2018
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Body mass index and craving predict 24-month hospital readmissions of alcohol-dependent in-patients following withdrawal.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Nov 26. Epub 2018 Nov 26.

Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany.

Objective: Addictive alcohol drinking, craving, and overeating share common etiopathological mechanisms. We investigated whether body mass index (BMI) and craving predict outcome of alcohol-dependent in-patients.

Method: The prospective study included 101 male and 72 female early-abstinent alcohol-dependent in-patients. Read More

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November 2018
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Choosing the appropriate pharmacotherapy for obsessive-compulsive disorder in adult patients with comorbid anxiety disorders: clinical and nosological considerations.

Authors:
Michele Fornaro

Expert Opin Pharmacother 2018 Nov 29:1-4. Epub 2018 Nov 29.

a Department of Neuroscience , Reproductive Sciences and Dentistry, Federico II University , Naples , Italy.

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November 2018
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3.534 Impact Factor