297,141 results match your criteria Obesity Silver Spring Md.[Journal]


Investigating the Association Between Baseline Characteristics (HbA1c and Body Mass Index) and Clinical Outcomes of Fast-Acting Insulin Aspart in People with Diabetes: A Post Hoc Analysis.

Diabetes Ther 2018 Dec 13. Epub 2018 Dec 13.

Clinical and Experimental Endocrinology, University Hospital Leuven, Catholic University of Leuven, Leuven, Belgium.

Introduction: The aim of this study was to investigate the association between baseline characteristics [HbA1c and body mass index (BMI)] and the effect of mealtime fast-acting insulin aspart (faster aspart) relative to insulin aspart (IAsp) or basal-only insulin therapy on several efficacy and safety outcomes in people with diabetes.

Methods: Post hoc analysis of three randomised phase 3a trials in people with type 1 diabetes (T1D; onset 1) and type 2 diabetes (T2D; onset 2 and 3). Participants (N = 1686) were stratified according to baseline BMI (< 25 kg/m, 25-< 30 kg/m, ≥ 30 kg/m) or HbA1c (≤ 58 mmol/mol, > 58-< 64 mmol/mol, ≥ 64 mmol/mol; ≤ 7. Read More

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December 2018
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Relationship of leptin, growth hormone, and insulin-like growth factor levels with body mass index and disease severity in patients with fibromyalgia syndrome.

Acta Neurol Belg 2018 Dec 13. Epub 2018 Dec 13.

Physical Medicine and Rehabilitation Clinic, Bingöl State Hospital, Bingöl, Turkey.

Objective: A high prevalence of obesity in fibromyalgia syndrome (FMS) predisposes patients to metabolic changes. It is not clear how the clinical manifestations of the disease affect metabolism. This study aimed to investigate leptin, growth hormone (GH), and insulin-like growth factor (IGF-1) levels in FMS, and their relationship with body mass index (BMI) and disease severity. Read More

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December 2018

Understanding Patient Preferences and Unmet Needs in Non-alcoholic Steatohepatitis (NASH): Insights from a Qualitative Online Bulletin Board Study.

Adv Ther 2018 Dec 13. Epub 2018 Dec 13.

Novartis Healthcare Pvt Ltd, Hyderabad, India.

Introduction: The aim of this work was to understand how patients with non-alcoholic steatohepatitis (NASH) perceive their disease, unmet needs, and expectations regarding future treatment through online bulletin board (OBB) qualitative research.

Methods: OBB is an asynchronous online qualitative market research tool that provides an open forum for interactive discussion among participants. Patients with NASH were recruited via physician referral and completed a screener questionnaire to ensure their eligibility and willingness to participate. Read More

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December 2018

Screening of Genetic Factor in the Interaction Between Periodontitis and Metabolic Traits Using Candidate Gene Association Study (CGAS).

Authors:
Kyung-Hui Moon

Biochem Genet 2018 Dec 13. Epub 2018 Dec 13.

Department of Dental Hygiene, Jinju Health College, Uibyeong-ro 51, Jinju, Korea.

Periodontitis has been reported to relate to metabolic syndrome traits such as obesity, blood pressure, and so on. However, the relation between periodontitis and metabolic syndrome remains unclear. The present study aimed to confirm common genetic factors between periodontitis and metabolic traits using Candidate gene association study (CGAS) in the Korean population. Read More

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December 2018

Development of Novel Free Radical Initiated Peptide Sequencing Reagent: Application to Identification and Characterization of Peptides by Mass Spectrometry.

J Am Soc Mass Spectrom 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemistry and Biochemistry, Center for Quantitative Obesity Research, Montclair State University, 1 Normal Avenue, Montclair, NJ, 07043, USA.

By incorporating a high proton affinity moiety to the charge localized free radical-initiated peptide sequencing (CL-FRIPS) reagent, FRIPS-MS technique has extended the applicability to hydrophobic peptides and peptides without basic amino acid residues (lysine, arginine, and histidine). Herein, the CL-FRIPS reagent has three moieties: (1) pyridine acting as the basic site to locate the proton, (2) 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO, a stable free radical) acting as the free radical precursor to generate the nascent free radical in the gas phase, and (3) N-hydroxysuccinimide (NHS) activated carboxylic acid acting as the coupling site to derivatize the N-terminus of peptides. The CL-FRIPS reagent allows for the characterization of peptides by generating sequencing ions, enzymatic cleavage-like radical-induced side chain losses, and the loss of TEMPO simultaneously via one-step collisional activation. Read More

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December 2018

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.

Diabetologia 2018 Dec 13. Epub 2018 Dec 13.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aims/hypothesis: Identifying rare coding variants associated with albuminuria may open new avenues for preventing chronic kidney disease and end-stage renal disease, which are highly prevalent in individuals with diabetes. Efforts to identify genetic susceptibility variants for albuminuria have so far been limited, with the majority of studies focusing on common variants.

Methods: We performed an exome-wide association study to identify coding variants in a two-stage (discovery and replication) approach. Read More

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December 2018

A call for improved reporting of human islet characteristics in research articles.

Diabetologia 2018 Dec 14. Epub 2018 Dec 14.

Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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December 2018

Providers' Involvement of Parents, Families, and Family Dynamics in Youth Weight Management Programs.

Glob Pediatr Health 2018 4;5:2333794X18817134. Epub 2018 Dec 4.

East Carolina University, Greenville, NC, USA.

Family-based interventions are the current standard for the treatment of pediatric obesity, yet the details of how providers are involving family members, and the barriers to family involvement, are largely unknown. The objective of this study is to describe how providers in pediatric weight management (PWM) involve family members, identify barriers to family involvement, and how they address challenging family dynamics. A cross-sectional survey was administered to PWM centers/clinics and their providers in the United States and Canada. Read More

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December 2018

Abdominal and Thigh Muscle Attenuation Is Associated With Visceral Fat and Age in Children and Adolescents With Obesity.

Glob Pediatr Health 2018 4;5:2333794X18817121. Epub 2018 Dec 4.

Mie University, Tsu, Mie, Japan.

. This study investigated relationships between adipose tissue deposition within skeletal muscle and morphological and biochemical variables in children with obesity. . Read More

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December 2018

Guideline Approaches for Cardioendocrine Disease Surveillance and Treatment Following Spinal Cord Injury.

Curr Phys Med Rehabil Rep 2018 15;6(4):264-276. Epub 2018 Nov 15.

1The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL USA.

Purpose Of Review: Persons with spinal cord injuries (SCI) commonly experience individual risks and coalesced health hazards of the cardiometabolic syndrome (CMS). This review will examinethe role of exercise and nutritional intervention as countermeasures to these disease risks.

Recent Findings: The CMS hazards of overweight/obesity, insulin resistance, hypertension, and dyslipidemia are strongly associated with physical deconditioning and are common after SCI. Read More

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November 2018

Fatigued Patients with Chronic Liver Disease Have Subtle Aberrations of Sleep, Melatonin and Cortisol Circadian Rhythms.

Fatigue 2018 3;6(1):5-19. Epub 2017 Dec 3.

Liver & Energy Metabolism Unit, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.

Aims: We sought to examine whether disturbances in central and peripheral circadian rhythms were related to the experience of fatigue in patients with chronic liver disease (CLD).

Methods: Fatigued and non-fatigued patients with compensated CLD were enrolled in a prospective pilot study. Patients underwent a one week evaluation of free-living sleep and physical activity patterns, followed by a 24-hour admission, during which they underwent serial blood sampling, polysomnography, a 6-minute walk test and continuous core temperature measurements under standardized conditions. Read More

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December 2017
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A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry.

Biodes Manuf 2018 27;1(3):161-170. Epub 2018 Jul 27.

3Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Ln, Oxford, OX3 7JX UK.

There are 12 billion injections given worldwide every year. For many injections, the intramuscular route is favoured over the subcutaneous route due to the increased vascularity of muscle tissue and the corresponding increase in the bioavailability of drugs when administered intramuscularly. This paper is a review of the variables that affect the success of intramuscular injections and the implications that these success rates have in psychiatry and general medicine. Read More

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Healthy Life Centre participants' perceptions of living with overweight or obesity and seeking help for a perceived "wrong" lifestyle - a qualitative interview study.

BMC Obes 2018 6;5:42. Epub 2018 Dec 6.

1Faculty of Health and Social Sciences, Department of Health and Caring Science, Western Norway University of Applied Sciences, Bjørnsons gate 45, 5528 Haugesund, Norway.

Background: Overweight and obesity are complex conditions, associated with a wide range of serious health issues. In contemporary society, body size is an important part of a person's self-representation. Lifestyle changes are difficult and long-term weight management is associated with a high risk of failure. Read More

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December 2018

Canagliflozin improves obesity and insulin resistance in a diabetic patient with Cushings disease undergoing postoperative steroid therapy: A case report.

Biomed Rep 2018 Dec 1;9(6):497-502. Epub 2018 Oct 1.

Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

A 47-year-old woman with diabetes treated with high-dose insulin was admitted to Mie University Hospital, Tsu, Japan, for screening of secondary diabetes mellitus and obesity. Laboratory tests and imaging studies were consistent with Cushing's disease (CD). The patient underwent trans-sphenoidal pituitary surgery. Read More

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December 2018

Sustainable food systems-a health perspective.

Sustain Sci 2018 12;13(6):1505-1517. Epub 2018 Jun 12.

7Departments of Population Health and of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK.

Malnutrition in all forms, ranging from undernourishment to obesity and associated diet-related diseases, is one of the leading causes of death worldwide, while food systems often have major environmental impacts. Rapid global population growth and increases in demands for food and changes in dietary habits create challenges to provide universal access to healthy food without creating negative environmental, economic, and social impacts. This article discusses opportunities for and challenges to sustainable food systems from a human health perspective by making the case for avoiding the transition to unhealthy less sustainable diets (using India as an exemplar), reducing food waste by changing consumer behaviour (with examples from Japan), and using innovations and new technologies to reduce the environmental impact of healthy food production. Read More

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Beta 1, Beta 2 and Beta 3 Adrenergic Receptor Gene Polymorphisms in a Southeastern European Population.

Front Genet 2018 28;9:560. Epub 2018 Nov 28.

Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece.

Genetic polymorphisms in β-, β- and β-adrenergic receptors (β-ARs) have been associated with chronic non-communicable disorders, such as cardiovascular diseases, asthma, chronic obstructive pulmonary disease (COPD) and obesity, as well as β-agonists and antagonists response and toxicity. The purpose of this study was to determine the frequency distribution of genetic variants Ser49Gly and Arg389Gly, variants Gly16Arg and Gln27Glu, variant Trp64Arg in a Southeastern European Caucasian (SEC) population sample and to establish a comparison with existing data from other human populations. A sample of 431 men and 590 women volunteered to participate in this genotyping analysis after anonymization and de-identification. Read More

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November 2018

Diabetic and Elder Patients Experience Superior Cardiovascular Benefits After Gastric Bypass Induced Weight Loss.

Front Endocrinol (Lausanne) 2018 28;9:718. Epub 2018 Nov 28.

Endocrine, Cardiovascular and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.

Obesity and obesity related co-morbidities are well-recognized risks for cardiovascular (CV) disease and mortality. Weight loss improves CV risk factors and the efficacy of bariatric surgery in decreasing CV mortality is now well-established. Our aim was to assess CV risk progression and occurrence of CV events in a cohort of patients that underwent Roux-en-Y gastric bypass (RYGB) for obesity treatment in a single academic public center. Read More

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November 2018

Relationship Between Obesity, Physical Activity, and Cardiorespiratory Fitness Levels in Children and Adolescents in Bosnia and Herzegovina: An Analysis of Gender Differences.

Front Physiol 2018 28;9:1734. Epub 2018 Nov 28.

Department for Health Sciences, Faculty of Human Sciences, Mid Sweden University, Sundsvall, Sweden.

This study aimed to examine: (i) the level of physical activity (PA), obesity indices and cardiorespiratory fitness (CRF) among boys and girls in primary school, and (ii) to determine the association of obesity indices and PA with CRF for the total number of participants, and then separately for boys and girls. 753 sixth to ninth grade girls and boys aged 10-14 years took part in this cross-sectional study. The PA was assessed by the "Physical Activity Questionnaire - Children" and CRF was assessed by the Maximal multistage a 20 m shuttle run test. Read More

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November 2018

Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis.

Front Pharmacol 2018 28;9:1393. Epub 2018 Nov 28.

Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom.

Antipsychotic drugs may lead to side effects such as obesity, diabetes, dyslipidemia, and cardiovascular disease. The current systematic review and network meta-analysis analyzes and provides an update on the clinical performance of these add-ons in comparison to placebo on body weight and body mass index (BMI) reductions. A comprehensive literature search was performed on electronic databases: PubMed (1946-), Embase (1974-), Cochrane library (1992-), and OpenGrey (2000-) until 31 July 2018. Read More

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November 2018

Exploring the use of adjusted body mass index thresholds based on equivalent insulin resistance for defining overweight and obesity in UK South Asian children.

Int J Obes (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Population Health Research Institute, St George's, University of London, London, UK.

Background: Body mass index (BMI) overweight/obesity thresholds in South Asian (SA) adults, at equivalent type-2 diabetes risk are lower than for white Europeans (WE). We aimed to define adjusted overweight/obesity thresholds for UK-SA children based on equivalent insulin resistance (HOMA-IR) to WE children.

Methods: In 1138 WE and 1292 SA children aged 9. Read More

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December 2018

Overweight and obesity in preschool aged children and risk of mental health service utilization.

Int J Obes (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Objective: To determine if overweight or obesity in preschool-age children is associated with mental health service utilization in later childhood.

Subjects: Overall, 10,522 children 2 to <5 years, with no previous history of mental health service utilization, were identified from primary care electronic medical records (EMRs) across Ontario, Canada.

Methods: This was a retrospective longitudinal cohort study. Read More

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December 2018
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Development of insulin resistance in Nischarin mutant female mice.

Int J Obes (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, LA, 70112, USA.

Background/objectives: NISCH-STAB1 is a newly identified locus correlated to human waist-hip ratio (WHR), which is a risk indicator of developing obesity-associated diabetes. Our previous studies have shown that Nisch mutant male mice increased glucose tolerance in chow-fed conditions. Thus we hypothesized that Nisch mutant mice will have changes in insulin resistance, adipocytes, hepatic steatosis when mice are fed with high-fat diet (HFD). Read More

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December 2018

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.

Sci Rep 2018 Dec 13;8(1):17814. Epub 2018 Dec 13.

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, and the William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

Type 2 diabetes is an age-and-obesity associated disease driven by impairments in glucose homeostasis that ultimately result in defective insulin secretion from pancreatic β-cells. To deconvolve the effects of age and obesity in an experimental model of prediabetes, we fed young and aged mice either chow or a short-term high-fat/high-sucrose Western diet (WD) and examined how weight, glucose tolerance, and β-cell function were affected. Although WD induced a similar degree of weight gain in young and aged mice, a high degree of heterogeneity was found exclusively in aged mice. Read More

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December 2018

Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery.

Transl Psychiatry 2018 Dec 13;8(1):278. Epub 2018 Dec 13.

South Texas Diabetes and Obesity Institute, Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, San Antonio, TX, USA.

The dopaminergic hypothesis of schizophrenia (SZ) postulates that positive symptoms of SZ, in particular psychosis, are due to disturbed neurotransmission via the dopamine (DA) receptor D2 (DRD2). However, DA is a reactive molecule that yields various oxidative species, and thus has important non-receptor-mediated effects, with empirical evidence of cellular toxicity and neurodegeneration. Here we examine non-receptor-mediated effects of DA on gene co-expression networks and its potential role in SZ pathology. Read More

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December 2018

CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.

Science 2018 Dec 13. Epub 2018 Dec 13.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.

A wide-range of human diseases result from haploinsufficiency, where the function of one of the two gene copies is lost. Here, we targeted the remaining functional copy of a haploinsufficient gene using CRISPR-mediated activation (CRISPRa) in and heterozygous mouse models to rescue their obesity phenotype. Transgenic-based CRISPRa targeting of the promoter or its distant hypothalamic enhancer upregulated its expression from the endogenous functional allele in a tissue-specific manner, rescuing the obesity phenotype in heterozygous mice. Read More

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December 2018

Abdominal obesity, metabolic dysfunction, and metabolic syndrome in U.S. adolescents: National Health and Nutrition Examination Survey 2011-2016.

Ann Epidemiol 2018 Nov 23. Epub 2018 Nov 23.

Epidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA. Electronic address:

Purpose: The objectives were to use National Health and Nutrition Examination Survey data to (1) estimate the prevalence of metabolic syndrome (MetS) risk factors (elevated blood pressure, triglycerides, blood glucose, and low HDL cholesterol); (2) estimate the prevalence of MetS using three common definitions; and (3) compare the odds of MetS risk factors/MetS when using different measures of abdominal obesity (sagittal abdominal diameter [SAD] versus waist circumference [WC]) among U.S. adolescents. Read More

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November 2018

Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery.

Surg Obes Relat Dis 2018 Nov 2. Epub 2018 Nov 2.

Department of Food Science and Human Nutrition, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois; Division of Nutritional Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois. Electronic address:

Background: Roux-en-Y gastric bypass surgery (RYGB) increases the rate of alcohol absorption so that peak blood alcohol concentration is 2-fold higher after surgery compared with concentrations reached after consuming the same amount presurgery. Because high doses of alcohol can lead to hypoglycemia, patients may be at increased risk of developing hypoglycemia after alcohol ingestion.

Objectives: We conducted 2 studies to test the hypothesis that the consumption of approximately 2 standard drinks of alcohol would decrease glycemia more after RYGB than before surgery. Read More

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November 2018
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Role of hyperglycaemia in the relationship between serum osteocalcin levels and relative skeletal muscle index.

Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China. Electronic address:

Background & Aims: Studies have shown that osteocalcin is involved in energy metabolism and is sufficient to prevent age-related muscle loss. The present study investigated the association of serum osteocalcin levels with muscle mass and the influence of metabolic factors on this association in humans.

Methods: A total of 1742 middle-aged and elderly subjects (median age: 61. Read More

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November 2018

Body fat percentage assessment by ultrasound subcutaneous fat thickness measurements in middle-aged and older adults.

Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.

Department of Sports and Life Sciences, National Institute of Fitness and Sports in Kanoya, Kanoya, Kagoshima 891-2393, Japan.

Background & Aims: B-mode ultrasound accurately measures both muscle mass, body density and percent body fat (% BF) in younger adults, but how well it can estimate % BF in middle-aged and older adults using DXA-derived %BF as the criterion is unclear. We sought to develop % BF prediction equations for middle-aged and older adults using ultrasound subcutaneous fat thickness (SFT).

Methods: A cross-sectional study of Japanese adults (n = 414, 50-79 years) where 276 subjects were randomly assigned to a model development group and the other 138 subjects were assigned to a cross-validation group. Read More

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November 2018

Loss of μ-crystallin causes PPARγ activation and obesity in high-fat diet-fed mice.

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, 390-8621, Japan.

The thyroid hormone-binding protein μ-crystallin (CRYM) mediates thyroid hormone action by sequestering triiodothyronine in the cytoplasm and regulating the intracellular concentration of thyroid hormone. As thyroid hormone action is closely associated with glycolipid metabolism, it has been proposed that CRYM may contribute to this process by reserving or releasing triiodothyronine in the cytoplasm. We aimed to clarify the relationship between CRYM and glycolipid metabolism by comparing wild-type and CRYM knockout mice fed a high-fat diet. Read More

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December 2018
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Randomized sham-controlled trial of the 6-month swallowable gas-filled intragastric balloon system for weight loss.

Surg Obes Relat Dis 2018 Dec 29;14(12):1876-1889. Epub 2018 Sep 29.

Stony Brook Medicine, Stony Brook, New York.

Background: Obesity is a significant health problem and additional therapies are needed to improve obesity treatment.

Objective: Determine the efficacy and safety of a 6-month swallowable gas-filled intragastric balloon system for weight loss.

Setting: Fifteen academic and private practice centers in the United States. Read More

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December 2018

Enhanced recovery after surgery (ERAS) in one-anastomosis gastric bypass surgery: a matched-cohort study.

Surg Obes Relat Dis 2018 Dec 11;14(12):1850-1856. Epub 2018 Sep 11.

Department of General Surgery, Elazig Education and Research Hospital, Elazig, Turkey.

Background: One-anastomosis gastric bypass (OAGB) is considered new from the bariatric standpoint.

Objectives: To assess the effectiveness and safety of the enhanced recovery after surgery protocol compared with the conventional approach in perioperative care of OAGB patients.

Setting: Turkey. Read More

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December 2018

Body Mass Index in Children Validated by Metabolic and Fat Mass Profiling.

J Am Coll Cardiol 2018 Dec;72(24):3155-3157

Heart Health Theme, South Australian Health and Medical Research Institute, Adelaide, Australia; School of Biological Sciences, University of Adelaide, South Australia, Australia. Electronic address:

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December 2018

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages.

Lipids Health Dis 2018 Dec 13;17(1):285. Epub 2018 Dec 13.

Genomics and Biomarkers Unit, National Institute for Health and Welfare, FI-00251, Helsinki, Finland.

Background: The focus of studies on high-density lipoproteins (HDL) has shifted from HDL-cholesterol (HDL-C) to HDL function. We recently demonstrated that low USF1 expression in mice and humans associates with high plasma HDL-C and low triglyceride levels, as well as protection against obesity, insulin resistance, and atherosclerosis. Here, we studied the impact of USF1 deficiency on HDL functional capacity and macrophage atherogenic functions, including inflammation, cholesterol efflux, and cholesterol accumulation. Read More

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December 2018
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GLP-1RAs in type 2 diabetes: mechanisms that underlie cardiovascular effects and overview of cardiovascular outcome data.

Cardiovasc Diabetol 2018 Dec 13;17(1):157. Epub 2018 Dec 13.

Cardiology Division, Pontifical Catholic University of Campinas Medicine School, Rua Engenheiro Carlos Stevenson 560, Campinas, Sao Paulo, 13092-132, Brazil.

Patients with type 2 diabetes (T2DM) have a substantial risk of developing cardiovascular disease. The strong connection between the severity of hyperglycaemia, metabolic changes secondary to T2DM and vascular damage increases the risk of macrovascular complications. There is a challenging demand for the development of drugs that control hyperglycaemia and influence other metabolic risk factors to improve cardiovascular outcomes such as cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina and heart failure (major adverse cardiovascular events). Read More

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December 2018
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Perioperative surgery- and anaesthesia-related risks of laparoscopic Roux-en-Y gastric bypass - a single centre, retrospective data analysis.

BMC Anesthesiol 2018 Dec 13;18(1):190. Epub 2018 Dec 13.

Institute of Anaesthesiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Background: Conservative obesity treatment often leads to limited results. Bariatric surgery is highly efficient, but the candidates are at risk of developing perioperative complications. Bariatric outcomes have been well described in the past, but there are only few reports of perioperative outcomes. Read More

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December 2018

Association Between High Neutrophil to Lymphocyte Ratio and Delayed Recovery From Bell's Palsy.

Clin Exp Otorhinolaryngol 2018 Dec 15. Epub 2018 Dec 15.

Department of Otolaryngology-Head and Neck Surgery, Graduate School, Kyung Hee University, Seoul, Korea.

Objectives: Factors predictive of the severity of and recovery from Bell's palsy remain unclear. This study evaluated the association between neutrophil to lymphocyte ratio (NLR) and the severity of and recovery from Bell's palsy.

Methods: This retrospective study included 51 patients who were hospitalized with Bell's palsy from 2015 to 2017. Read More

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December 2018

Effectiveness of the Nutritional App "MyNutriCart" on Food Choices Related to Purchase and Dietary Behavior: A Pilot Randomized Controlled Trial.

Nutrients 2018 Dec 12;10(12). Epub 2018 Dec 12.

Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, San Juan 00935, Puerto Rico.

Objective: To pilot test the effectiveness of "MyNutriCart", a smartphone application (app) that generates healthy grocery lists, on diet and weight.

Methods: A pilot randomized trial was conducted to test the efficacy of using the "MyNutriCart" app compared to one face-to-face counseling session (Traditional group) in Hispanic overweight and obese adults. Household food purchasing behavior, three 24-h food recalls, Tucker's semi-quantitative food frequency questionnaire (FFQ), and weight were assessed at baseline and after 8 weeks. Read More

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December 2018

Food Parenting Practices among Parents with Overweight and Obesity: A Systematic Review.

Nutrients 2018 Dec 12;10(12). Epub 2018 Dec 12.

Applied Psychology, International Digital Laboratory, Warwick Manufacturing Group, University of Warwick, Coventry CV4 7AL, UK.

Given the links between parental obesity and eating psychopathology in their children, it is important to understand the mechanisms via which unhealthy relationships with eating are passed from generation to generation. The aim was to review research focusing on food-related parenting practices (FPPs) used by parents with overweight/obesity. Web of Science, PubMed and PsycINFO were searched. Read More

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December 2018

Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue.

Nutrients 2018 Dec 12;10(12). Epub 2018 Dec 12.

College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University, Seoul 08826, Korea.

Myricetin is a biologically active natural polyphenol with beneficial effects on metabolic health. This study aimed to examine the effects of myricetin on the expression levels of genes involved in lipolysis and mitochondrial respiration in adipocytes and the anti-obesity potential of myricetin. The results indicated that myricetin reduced triglyceride (TG) content and increased mitochondrial content and oxygen consumption rate (OCR) in adipocytes in vitro. Read More

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December 2018

Decreased PEDF Expression Promotes Adipogenic Differentiation through the Up-Regulation of CD36.

Int J Mol Sci 2018 Dec 11;19(12). Epub 2018 Dec 11.

Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.

Adipogenesis is a tightly regulated cellular process that involves the action of multiple signaling pathways. Characterization of regulators that are associated with adipose development is crucial to understanding the mechanisms underlying obesity and other metabolic disorders. Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein that was first described as a neurotrophic factor. Read More

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December 2018

Relative Density of Away from Home Food Establishments and Food Spend for 24,047 Households in England: A Cross-Sectional Study.

Int J Environ Res Public Health 2018 Dec 11;15(12). Epub 2018 Dec 11.

UKCRC Centre for Diet and Activity Research (CEDAR), MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Eating away from home is a risk factor for poor diet quality and obesity. With an ever-increasing proportion of household food spend directed toward eating out, the proliferation of these food establishments may contribute to their use, a potential precursor to less healthy food choices and low overall diet quality. However few studies are conducted at the national level and across a range of away from home food sources. Read More

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December 2018

Differing Contributions of Classical Risk Factors to Type 2 Diabetes in Multi-Ethnic Malaysian Populations.

Int J Environ Res Public Health 2018 Dec 10;15(12). Epub 2018 Dec 10.

Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, 2308, Australia.

The prevalence of type 2 diabetes is escalating rapidly in Asian countries, with the rapid increase likely attributable to a combination of genetic and lifestyle factors. Recent research suggests that common genetic risk variants contribute minimally to the rapidly rising prevalence. Rather, recent changes in dietary patterns and physical activity may be more important. Read More

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December 2018

The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT.

Medicine (Baltimore) 2018 Dec;97(49):e13233

Department of Radiology, Hillel Yaffe Medical Center, Hadera, Affiliated with the Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, Israel.

Cardiovascular (CV) morbidity, atherosclerosis, and obesity are all targets of clinical concern and vast research, as is the association between them. Aim of this study is to assess the impact of adipose tissue (including visceral and subcutaneous fat) on abdominal aorta calcification measured on non-enhanced computed tomography (CT). We retrospectively included 492 patients who underwent non-enhanced CT scans during workup for clinically suspected renal colic. Read More

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December 2018
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Obesity and risk of urinary tract infection in young children presenting with fever.

Medicine (Baltimore) 2018 Dec;97(49):e13006

Department of Pediatrics, Tri-Service General Hospital, Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan.

Obesity may increase the risk of infection, but the association between obesity and febrile urinary tract infection (fUTI) is controversial. Although the prevalence of infant and childhood obesity has been increasing worldwide, the results of previous investigations on the association with urinary tract infection (UTI) are conflicting. The purpose of this study was to evaluate the relationship between overweight and obesity and UTI in febrile children. Read More

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December 2018

Deterioration in right ventricular structure and function over time in patients with heart failure and preserved ejection fraction.

Eur Heart J 2018 Dec 12. Epub 2018 Dec 12.

The Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, USA.

Aims: Prevalent right ventricular (RV) dysfunction (RVD) is associated with increased mortality in patients with heart failure with preserved ejection fraction (HFpEF), but no study has characterized long-term changes in RV structure and function within the same patient.

Methods And Results: Patients with unequivocal HFpEF defined by either invasive haemodynamics or hospitalization for pulmonary oedema (n = 271) underwent serial echocardiographic evaluations >6 months apart. Clinical, structural, functional, and haemodynamic characteristics were examined. Read More

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December 2018

Cytokine, chemokine and cytokine receptor changes are associated with metabolic improvements after bariatric surgery.

J Clin Endocrinol Metab 2018 Dec 13. Epub 2018 Dec 13.

Department of Physiology, and Center for Metabolism and Obesity Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Context: Altered cytokine levels and chronic low-grade inflammation contributes to metabolic dysfunction in obesity. The extent of cytokine changes and their impact on metabolic improvements following bariatric surgery has not been fully explored.

Objective: To compare 76 circulating cytokines, chemokines, and secreted cytokine receptors in obese and lean subjects, and determine how these cytokines are altered by bariatric surgery. Read More

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December 2018

Precision nutrition: hype or hope for public health interventions to reduce obesity?

Int J Epidemiol 2018 Dec 12. Epub 2018 Dec 12.

Département de médecine sociale et préventive, Ecole de Santé Publique & Institut de recherche en santé publique de l'Université de Montréal, Université de Montréal, Montreal, QC, Canada.

High-income countries are experiencing an obesity epidemic that follows a socioeconomic gradient, affecting groups of lower socioeconomic status disproportionately. Recent clinical findings have suggested new perspectives for the prevention and treatment of obesity, using personalized dietary approaches. Precision nutrition (PN), also called personalized nutrition, has been developed to deliver more preventive and practical dietary advice than 'one-size-fits-all' guidelines. Read More

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December 2018

Using a holistic health approach to achieve weight-loss maintenance: results from the Spirited Life intervention.

Transl Behav Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Biostatistics and Bioinformatics, Duke Global Health Institute, Duke University, Durham, NC, USA.

Weight-loss maintenance is essential to sustain the health benefits of weight loss. Studies with lower intensity intervention supports under real-world conditions are lacking. This study examined changes in weight and cardiometabolic biomarkers among Spirited Life participants following initial 12-month weight loss at 12-24 months and 24-42 months. Read More

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December 2018

Sex differences in inflammatory responses to adipose tissue lipolysis in diet-induced obesity.

Endocrinology 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics and Communicable Disease, University of Michigan Medical School, Ann Arbor, MI.

Males are known to have profound adipose tissue macrophage (ATM) accumulation in gonadal white adipose tissue (GWAT) during obesity, while females are protected from such an inflammatory response even with increased adiposity. The inflammatory tone in males is linked to insulin resistance and might be the underlying cause for sex differences in metabolic disease. Factors regulating the meta-inflammatory response remain unclear but enhanced lipid storage in females may explain the reduced inflammatory response to high fat diets. Read More

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December 2018