305,432 results match your criteria Obesity Silver Spring Md.[Journal]


Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

Aging (Albany NY) 2019 Apr;11(7):2045-2070

See ACKNOWLEDGMENTS AND FUNDING.

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. Read More

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http://dx.doi.org/10.18632/aging.101900DOI Listing

The influence of childhood obesity on spatio-temporal gait parameters.

Gait Posture 2019 Mar 30;71:69-73. Epub 2019 Mar 30.

Podiatry Department, Health Sciences Faculty, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Spain. Electronic address:

The musculoskeletal and neurosensorial development of children can be affected by excess body weight. Studies have examined how childhood obesity affects gait, but much about the influence of this factor remains to be determined. The aim of our study is to analyse, in a large sample of children, the influence of obesity on the spatiotemporal parameters of the gait cycle, in the most natural way possible, with the subjects walking overground at a self-selected speed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183191
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http://dx.doi.org/10.1016/j.gaitpost.2019.03.031DOI Listing
March 2019
1 Read

Multitarget PPARγ agonists as innovative modulators of the metabolic syndrome.

Eur J Med Chem 2019 Apr 13;173:261-273. Epub 2019 Apr 13.

Department of Pharmacy, University of Chieti "G. d.Annunzio", Via Dei Vestini, 31, 66100, Chieti, Italy.

A multitarget pharmacologic approach could be advantageous for the therapy of metabolic multiple diseases, such as the metabolic syndrome, which is characterized by metabolic abnormalities associated with diabetes, obesity, hypertension, and increased cardiovascular risk. PPAR receptors play a critical role in metabolic disorders, affecting glucose and lipid metabolism. Drugs simultaneously targeting PPAR and other validated metabolic targets, represent a promising multitarget approach to combine antihyperglycemic, antihyperlipidemic, and antihypertensive effects. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.030DOI Listing

"Closed-Incision Negative-Pressure Therapy Efficacy in Abdominal Wall Reconstruction in High-Risk Patients: A Meta-Analysis".

J Surg Res 2019 Apr 19;241:63-71. Epub 2019 Apr 19.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Obesity is a known risk factor for surgical complications. Closed-incision negative-pressure therapy (ciNPT) has been used anecdotally in high-risk patients to prevent wound complications and infection. This meta-analysis aims to evaluate the efficacy of ciNPT in reducing the incidence of wound complications and infection in abdominal wall reconstruction. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.033DOI Listing

Risk Factors for Severe Liver Disease in Patients With Type 2 Diabetes.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Upper Gastrointestinal Diseases, Division of Hepatology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Background & Aims: Type 2 diabetes is a risk factor for development of cirrhosis and hepatocellular carcinoma. However, risk factor that identify persons with the highest risk for these outcomes are missing from unselected, population-based cohorts.

Methods: The National Diabetes Register contains data on about 90% of persons in Sweden with type 2 diabetes. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.038DOI Listing

Behavioral profile of intermittent vs continuous access to a high fat diet during adolescence.

Behav Brain Res 2019 Apr 19. Epub 2019 Apr 19.

Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Avda. Blasco Ibáñez, 21, 46010 Valencia, Spain. Electronic address:

Over the past few years, the effects of a high-fat diet (HFD) on cognitive functions have been broadly studied as a model of obesity, although no studies have evaluated whether these effects are maintained after the cessation of this diet. In addition, the behavioral effects of having a limited access to an HFD (binge-eating pattern) are mostly unknown, although they dramatically increase the vulnerability to drug use in contrast to having continuous access. Thus, the aim of the present study was to compare the effects of an intermittent versus a continuous exposure to an HFD during adolescence on cognition and anxiety-like behaviors, as well as to study the changes observed after the interruption of this diet. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.005DOI Listing

Aerobic exercise improves food reward systems in obese rats via insulin signalling regulation of dopamine levels in the nucleus accumbens.

ACS Chem Neurosci 2019 Apr 22. Epub 2019 Apr 22.

The dopaminergic pathway, comprising projections from the ventral tegmental area to the nucleus accumbens, constitutes the core of the brain reward system. Insufficient food reward caused by dopamine signalling dysfunction in the nucleus accumbens is an important contributor to obesity and may be associated with insulin signalling. Aerobic exercise has a positive effect both on preventing and treating obesity. Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00022DOI Listing

Predicting childhood obesity using electronic health records and publicly available data.

PLoS One 2019 22;14(4):e0215571. Epub 2019 Apr 22.

NYU Langone Comprehensive Program on Obesity, NYU School of Medicine, New York, New York, United States of America.

Background: Because of the strong link between childhood obesity and adulthood obesity comorbidities, and the difficulty in decreasing body mass index (BMI) later in life, effective strategies are needed to address this condition in early childhood. The ability to predict obesity before age five could be a useful tool, allowing prevention strategies to focus on high risk children. The few existing prediction models for obesity in childhood have primarily employed data from longitudinal cohort studies, relying on difficult to collect data that are not readily available to all practitioners. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215571PLOS

Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos.

PLoS One 2019 22;14(4):e0215378. Epub 2019 Apr 22.

Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of America.

Objective: Hispanics/Latinos have some of the highest prevalence rates for cardiovascular disease risk factors, but stark differences exist by self-reported background. Cardiovascular disease risk factors negatively impact cognition in Hispanics/Latinos; less is known about these relationships by Hispanic/Latino backgrounds. We investigated cognitive associations with cardiovascular disease risk factor burden in a diverse cohort, the Hispanic Community Health Study/Study of Latinos. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215378PLOS
April 2019
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Clinical and Demographic Trends in Cardiac Rehabilitation: 1996-2015.

J Cardiopulm Rehabil Prev 2019 Apr 18. Epub 2019 Apr 18.

University of Vermont College of Medicine, Burlington (Drs Gaalema, Naud, Priest, and Ades); and University of Vermont Medical Center, Burlington (Messrs Savage and Rengo and Drs Leadholm and Ades).

Purpose: Clinical interventions in programs such as cardiac rehabilitation (CR) are guided by clinical characteristics of participating patients. This study describes changes in CR participant characteristics over 20 yr.

Methods: To examine changes in patient characteristics over time, we analyzed data from 1996 to 2015 (n = 5396) garnered from a systematically and prospectively gathered database. Read More

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http://dx.doi.org/10.1097/HCR.0000000000000390DOI Listing

Attention-deficit hyperactivity disorder symptomatology, binge eating disorder symptomatology, and body mass index among college students.

J Am Coll Health 2019 Apr 22:1-7. Epub 2019 Apr 22.

d School of Humanities & Social Sciences , Penn State Erie, The Behrend College , Erie , Pennsylvania , USA.

Objective: To explore the relationship between symptoms of attention-deficit hyperactivity disorder (ADHD), symptoms of binge eating disorder, and body mass index (BMI) among students at a southern university.

Participants: Two hundred seventy-seven college students.

Methods: Between January 31, 2013 and March 27, 2013, participants completed the Adult ADHD Self-Report Scale (ASRS) Screener and the Binge Eating Scale (BES) in addition to permitting researchers to measure their height and weight. Read More

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http://dx.doi.org/10.1080/07448481.2019.1583651DOI Listing

Risk Factors and Outcomes for Sepsis after Appendectomy in Adults.

Surg Infect (Larchmt) 2019 Apr 20. Epub 2019 Apr 20.

Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Sepsis is an uncommon occurrence after appendectomy, but the morbidity and mortality of patients who develop sepsis after appendectomy remains exceedingly high. The purpose of this study is to identify risk factors and adverse post-operative outcomes associated with sepsis after appendectomy in adults. The American College of Surgery National Surgical Quality Improvement Program participant user database was queried from 2012 to 2015. Read More

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https://www.liebertpub.com/doi/10.1089/sur.2019.003
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http://dx.doi.org/10.1089/sur.2019.003DOI Listing
April 2019
2 Reads

Targeting Peroxisome Proliferator-Activated Receptor-Gamma Decreases Host Mortality After Influenza Infection in Obese Mice.

Viral Immunol 2019 Apr 19. Epub 2019 Apr 19.

1 Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

Obesity is an independent risk factor for severe influenza infection. However, the underlying cellular and molecular mechanisms are still incompletely understood. In this study, we have utilized a murine influenza infection model in genetic-induced obese (db/db) mice to explore the mechanisms by which obesity increases host susceptibility to influenza infection. Read More

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https://www.liebertpub.com/doi/10.1089/vim.2019.0016
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http://dx.doi.org/10.1089/vim.2019.0016DOI Listing
April 2019
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Identification and Management of Lymphedema in Patients With Breast Cancer.

J Oncol Pract 2019 Apr 22:JOP1800141. Epub 2019 Apr 22.

1 Nebraska Medical Center, Omaha, NE.

Breast cancer-related lymphedema (BCRL) is a potentially debilitating and often irreversible complication of breast cancer treatment. Risk of BCRL is proportional to the extent of axillary surgery and radiation. Other risk factors include obesity and infections. Read More

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http://dx.doi.org/10.1200/JOP.18.00141DOI Listing

Hypoxia inducible factor-1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN/p65 signaling pathway.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Department of Endocrinology and Metabolism, Qingdao Haici Hospital, Qingdao, Shandong, China.

Obesity is a major contributor to the development of steatohepatitis and fibrosis from nonalcoholic fatty liver disease (NAFLD). Hypoxia aggravates progression of NAFLD. In mice on high-fat diet (HFD), hepatic steatosis leads to liver tissue hypoxia, evidenced by accumulation of hypoxia inducible factor-1-alpha (HIF-1α), which is a central regulator of the global response to hypoxia. Read More

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http://dx.doi.org/10.1002/jcb.28734DOI Listing

Accelerometer activity tracking in horses and the effect of pasture management on time budget.

Equine Vet J 2019 Apr 22. Epub 2019 Apr 22.

Department of Clinical Science and Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK.

Background: Accelerometry is an accepted means of quantifying human physical activity. Quantitative physical activity tracking could be beneficial for studies into equine health and disease prevention, for example, in relation to obesity management.

Objectives: Validate accelerometer use in grazing horses, determine between-day repeatability, and assess the effects of pasture size on time budget (i. Read More

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http://dx.doi.org/10.1111/evj.13130DOI Listing

The evolving obesity paradigm story: from heart failure to atrial fibrillation.

Eur Heart J 2019 Apr 21. Epub 2019 Apr 21.

Division of Cardiology and Metabolism at Department of Cardiology (CVK); and Berlin-Brandenburg Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK) partner site Berlin; Charité Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz082DOI Listing

The Preventive Role of ACE Inhibitors/Angiotensin-II Receptor Blockers and β-Adrenergic Blockers in Anthracycline and Trastuzumab-Induced Cardiotoxicity.

Cardiol Rev 2019 Apr 12. Epub 2019 Apr 12.

New York Medical College/Westchester Medical Center, Valhalla, NY.

Anthracycline (doxorubicin) and trastuzumab treatments for cancer patients have been known to cause cardiotoxicity. The current recommendations for prevention of cardiac events from cancer chemotherapies are largely based on opinion. The American Society of Clinical Oncology recommends active screening and prevention of modifiable cardiovascular risk factors. Read More

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http://dx.doi.org/10.1097/CRD.0000000000000252DOI Listing

[miR-494-3p reduces insulin sensitivity in diabetic cardiomyocytes by down-regulation of insulin receptor substrate 1].

Sheng Li Xue Bao 2019 Apr;71(2):271-278

School of Aerospace Medicine, the Fourth Military Medical University, Xi'an 710032, China.

More and more evidence suggests that microRNA is widely involved in the regulation of cardiovascular function. Our preliminary experiment showed that miR-494-3p was increased in heart of diabetic rats, and miR-494-3p was reported to be related to metabolism such as obesity and exercise. Therefore, this study was aimed to explore the role of miR-494-3p in diabetic myocardial insulin sensitivity and the related mechanism. Read More

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[Recent progress on obesity-induced myocardial remodeling and its possible mechanism of mitochondrial dyshomeostasis].

Sheng Li Xue Bao 2019 Apr;71(2):216-224

Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.

Obesity is an important risk factor for cardiovascular diseases, which can lead to a variety of cardiovascular diseases including myocardial remodeling. Obesity may induce myocardial dysfunction by affecting hemodynamics, inducing autonomic imbalance, adipose tissue dysfunction, and mitochondrial dyshomeostasis. The key necessary biochemical functions for metabolic homeostasis are performed in mitochondria, and mitochondrial homeostasis is considered as one of the key determinants for cell viability. Read More

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Whole Egg Consumption Impairs Insulin Sensitivity in a Rat Model of Obesity and Type 2 Diabetes.

Curr Dev Nutr 2019 Apr 11;3(4):nzz015. Epub 2019 Mar 11.

Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011.

Background: The literature regarding the relation between egg consumption and type 2 diabetes (T2D) is inconsistent and there is limited evidence pertaining to the impact of egg consumption on measures of insulin sensitivity.

Objectives: The aim of this study was to investigate the effect of dietary whole egg on metabolic biomarkers of insulin resistance in T2D rats.

Methods: Male Zucker diabetic fatty (ZDF) rats ( = 12; 6 wk of age) and age-matched lean controls ( = 12) were randomly assigned to be fed a casein- or whole egg-based diet. Read More

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http://dx.doi.org/10.1093/cdn/nzz015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462456PMC

Relationship of Socioeconomic Status Indicators to Obesity in Hispanic and Non-Hispanic White Middle-Aged Women: A Population Study.

Int J Womens Health Wellness 2019 28;5(1). Epub 2019 Feb 28.

Department of Health Services, University of Washington, Seattle, USA.

Background: Obesity rates differ between Hispanic and White (non-Hispanic) women in the United States, with higher rates among Hispanic women. Socioeconomic processes contribute to this disparity both at the individual and the environmental level. Understanding these complex relationships requires multilevel analyses within cohorts of women that have a shared environment. Read More

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http://dx.doi.org/10.23937/2474-1353/1510090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469717PMC
February 2019

Prediabetes: An emerging public health concern in adolescents.

Endocrinol Diabetes Metab 2019 Apr 1;2(2):e00060. Epub 2019 Mar 1.

Faculty of Medicine, College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada.

Objectives: To identify the presence of risk factors for type 2 diabetes (ethnicity, body mass index, blood glucose tolerance and blood pressure) and to determine the prevalence of prediabetes and type 2 diabetes in Canadian adolescents attending two multicultural urban high schools.

Methods: A total of 266 multicultural urban high school students who live in a mid-sized Western Canadian city, aged 14-21, were screened for risk factors of prediabetes and type 2 diabetes in March-April 2018. Data with respect to demographics, family history of diabetes, anthropometrics, blood pressure and haemoglobin A1c (HbA1c) were collected. Read More

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http://dx.doi.org/10.1002/edm2.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458462PMC

Occurrence of severe hypoglycaemic events among US youth and young adults with type 1 or type 2 diabetes.

Endocrinol Diabetes Metab 2019 Apr 19;2(2):e00057. Epub 2019 Jan 19.

Department of Pediatrics University of Washington Seattle Washington.

Objective: Although severe hypoglycaemia (SH) can lead to adverse health outcomes, little is known about its occurrence and re-occurrence among youth with type 1 or type 2 diabetes.

Methods: This study included 2740 participants aged <20 years at diabetes diagnosis and 5-14 years diabetes duration from the SEARCH for Diabetes in Youth Cohort Study. Participants reported SH events in the past 6 months. Read More

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http://dx.doi.org/10.1002/edm2.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458461PMC

Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects.

Endocrinol Diabetes Metab 2019 Apr 17;2(2):e00056. Epub 2019 Jan 17.

Department of Clinical Sciences Lund Lund University Lund Sweden.

People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (60% from carbohydrate, 20% from protein, 20% from fat) over 5 or 12 minutes on separate days in random order. Breakfast ingestion increased circulating glucose and insulin with maximal levels seen at 30 minutes after start of meal ingestion with no significant difference in the two tests. Read More

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http://dx.doi.org/10.1002/edm2.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458458PMC

The benefits of non-surgical weight management on weight and glycaemic control in people with complex type 2 diabetes: A primary care service evaluation of clinical outcomes at 12 months.

Endocrinol Diabetes Metab 2019 Apr 8;2(2):e00045. Epub 2019 Feb 8.

Nutrition, Health & Research team Slimming World Alfreton UK.

Optimizing diabetes management in patients with complex type 2 diabetes (T2DM) and obesity presents challenges. This study evaluates weight and HbA1c at 12 months (primary outcomes) and blood pressure, lipids, medication and lifestyle changes (secondary outcomes) in patients referred by a diabetes specialist (DSN) to the weight management intervention (Slimming World). Patients attended up to 12 or 24 funded weekly group sessions. Read More

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http://dx.doi.org/10.1002/edm2.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458457PMC

The Association between Dietary Fat Pattern and the Risk of Type 2 Diabetes.

Prev Nutr Food Sci 2019 Mar 31;24(1):1-7. Epub 2019 Mar 31.

Department of Clinical Nutrition and Dietetics, Science and Research Branch, Islamic Azad University, Tehran 19585-466, Iran.

Despite several studies examining single dietary fats on type 2 diabetes (T2D) incidence, little is known about the effects of multiple fatty acids on the risk of T2D. We aimed to address this question in the Tehran Lipid and Glucose Study (TLGS) population. Dietary intakes of participants without T2D (n=2,139) were assessed using the validated food frequency questionnaire. Read More

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http://dx.doi.org/10.3746/pnf.2019.24.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456237PMC

Perceived risk of colorectal and breast cancers among women who are overweight or with obesity.

Prev Med Rep 2019 Jun 22;14:100845. Epub 2019 Mar 22.

Research fellow, Oak Ridge Institute for Science Education (ORISE), Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States of America.

Many overweight women or women with obesity do not acknowledge their high weight status and may be unaware of their elevated cancer risk. We explored the relationship between weight status and women's perceived risk of colorectal (CRC) and breast cancers, overall and by race/ethnicity, in a nationally representative sample. Data was combined from NHIS 2005, 2010, and 2015 sample adult questionnaires and cancer control supplements. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113355193003
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http://dx.doi.org/10.1016/j.pmedr.2019.100845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458496PMC
June 2019
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Association of rs1042713 with Obesity and Obesity-Related Phenotypes and Its Interaction with Dietary Fat in Modulating Glycaemic Indices in Malaysian Adults.

J Nutr Metab 2019 17;2019:8718795. Epub 2019 Mar 17.

School of Healthy Aging, Medical Aesthetics & Regenerative Medicine, UCSI University, KL Campus, Kuala Lumpur, Malaysia.

Gene-diet interaction studies have reported that individual variations in phenotypic traits may be due to variations in individual diet. Our study aimed to evaluate (i) the association of rs1042713 with obesity and obesity-related metabolic parameters and (ii) the effect of dietary nutrients on these associations in Malaysian adults. genotyping, dietary, physical activity, anthropometric, and biochemical data were collected from 79 obese and 99 nonobese individuals. Read More

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http://dx.doi.org/10.1155/2019/8718795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441509PMC

A Survey Identifying Nutritional Needs in a Contemporary Adult Cystic Fibrosis Cohort.

BMC Nutr 2019 7;5. Epub 2019 Jan 7.

Department of Medicine; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington School of Medicine, 1959 NE Pacific, Campus Box 356522, Seattle, WA, USA 98195-6522.

Background: Cystic fibrosis (CF) is a disease in which nutritional barriers are diverse and common, with malnutrition greatly influencing pulmonary trajectory and overall outcomes. Despite this, the most effective methods to optimize CF nutrition are unknown, and literature describing patients' perspectives on their specific nutritional needs is lacking, particularly in the modern era of CF care. This study aimed to identify the most important nutritional needs and desired health-improvement resources in a contemporary adult CF cohort. Read More

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http://dx.doi.org/10.1186/s40795-018-0266-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474380PMC
January 2019

Dyspnoea and restrictive lung disease due to mediastinal and pleural lipomatosis in morbid obesity.

Respirol Case Rep 2019 Jul 9;7(5):e00421. Epub 2019 Apr 9.

Department of Respiratory Medicine Waikato Hospital Hamilton New Zealand.

Dyspnoea in obese patients can be multifactorial and complex. Mediastinal and pleural lipomatosis can be associated with obesity and is usually considered asymptomatic and benign. We report an obese 39-year-old man who presented with progressive dyspnoea, where in addition to obstructive sleep apnoea and obesity hypoventilation syndrome, was found to have massive mediastinal and pleural lipomatosis causing restrictive lung disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rcr2.421
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http://dx.doi.org/10.1002/rcr2.421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454808PMC
July 2019
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Asthma and obesity in the Middle East region: An overview.

Ann Thorac Med 2019 Apr-Jun;14(2):116-121

Medical Research Center, Research Affairs, Hamad Medical Corporation, Doha, Qatar.

This paper aims to cover the current status of asthma and obesity in the Middle East, as well as to introduce the various studies tying the two diseases; further expanding on the proposed mechanisms. Finally, the paper covers recent literature related to sphingolipids and its role in asthma, followed by recommendations and future directions. In preparation of this paper, we searched PubMed and Google Scholar, with no restrictions, using the following terms; asthma, obesity, Middle East, sphingolipids. Read More

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http://dx.doi.org/10.4103/atm.ATM_115_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467016PMC

Evaluation of a clinical score for predicting atrial fibrillation in cryptogenic stroke patients with insertable cardiac monitors: results from the CRYSTAL AF study.

Ther Adv Neurol Disord 2019 11;12:1756286419842698. Epub 2019 Apr 11.

Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: The HAVOC score was previously developed to predict the risk of atrial fibrillation (AF) after cryptogenic stroke (CS) or transient ischemic attack (TIA). The purpose of this study was to apply the HAVOC score to patients who received insertable cardiac monitors (ICMs) in the CRYSTAL AF study.

Methods: All patients from the CRYSTAL AF study who received an ICM were included. Read More

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http://dx.doi.org/10.1177/1756286419842698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460885PMC
April 2019
1 Read

Association of nuts and unhealthy snacks with subclinical atherosclerosis among children and adolescents with overweight and obesity.

Nutr Metab (Lond) 2019 8;16:23. Epub 2019 Apr 8.

1Department of Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: The process of atherosclerosis begins early in childhood and usually remains asymptomatic until later in life. Carotid intima-media thickness (cIMT) as a marker of subclinical atherosclerosis could identify early vascular alterations. Unhealthy snacks consumption is associated with obesity and other CVD risk factors in children and adolescents. Read More

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http://dx.doi.org/10.1186/s12986-019-0350-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454780PMC

Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue.

J Oncol 2019 17;2019:7406078. Epub 2019 Mar 17.

Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.

The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great impact on health, lifestyle, and economic cost. One of the most current challenges of biomedical science faces is to understand the origin of the chronic nontransmissible diseases, such as obesity and cancer. Read More

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http://dx.doi.org/10.1155/2019/7406078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441533PMC

In BMI We Trust: Reframing the Body Mass Index as a Measure of Health.

Authors:
Iliya Gutin

Soc Theory Health 2018 Aug 25;16(3):256-271. Epub 2017 Oct 25.

The University of North Carolina-Chapel Hill, 155 Hamilton Hall, Chapel Hill, NC 27514.

Recent work in medical sociology has provided critical insights into distinguishing between obesity as a condition with severe individual- and population-level health consequences, and obesity as a socially undesirable, stigmatizing construct opposing thinness as the healthy ideal. Less often considered is the role of Body Mass Index (BMI) as the standard by which obesity and healthy weight are measured and defined. Addressing this issue, I begin by distinguishing between BMI as an empirical, objective measure of health, and BMI as an arbitrary, subjective label for categorizing the population. Read More

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http://dx.doi.org/10.1057/s41285-017-0055-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469873PMC

Trends in obesity prevalence among total hip arthroplasty patients and the effect on surgical outcomes, 2008-2016.

J Orthop 2019 Jul-Aug;16(4):347-352. Epub 2019 Apr 7.

Chief of Orthopaedic Surgery at Pennsylvania Hospital, Assistant Professor of Orthopaedic Surgery, Department of Orthopaedic Surgery University of Pennsylvania, 800 Spruce Street, 8th Floor Preston Building, Philadelphia, PA, 19107, USA.

Introduction: The prevalence of obesity continues to rise in parallel with demand for total hip arthroplasty (THA). This study aims to report obesity trends in primary THA and its effects on procedure outcomes in the United States, stratifying based on Body Mass Index (BMI).

Methods: Primary THA procedures were identified in the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database (2008-2016). Read More

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http://dx.doi.org/10.1016/j.jor.2019.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458338PMC

Awareness of the link between obesity and cancer in UK school curricula.

Lancet 2019 Apr;393(10181):1591-1592

Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(18)32765-XDOI Listing

The Mediating Role of Brown Fat and Skeletal Muscle Measured by F-Fluorodeoxyglucose in the Thermoregulatory System in Young Adults.

Obesity (Silver Spring) 2019 Apr 21. Epub 2019 Apr 21.

Promoting Fitness & Health Through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Objective: This study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity mediates the relationship between personal level of environmental temperature (Personal-ET) and wrist skin temperature (WT). Moreover, we examined whether BAT and skeletal muscle have a mediating role between Personal-ET and WT (as a proxy of peripheral vasoconstriction/vasodilation).

Methods: The levels of BAT were quantified by cold-induced F-fluorodeoxyglucose-positron emission tomography/computed tomography scan and measured the Personal-ET and WT by using iButtons (Maxim Integrated, Dallas, Texas) in 75 participants (74. Read More

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http://dx.doi.org/10.1002/oby.22461DOI Listing

Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet-Induced Obese Minipigs.

Obesity (Silver Spring) 2019 Apr 21. Epub 2019 Apr 21.

Translational Research Laboratory for Diabetes, Inserm U1190, Lille, France.

Objective: A minipig model was employed to explore the changes in endogenous leptin transport into the central nervous system and in hypothalamic sensitivity to exogenous leptin when individuals are placed on high-fat diet (HFD) compared with standard diet.

Methods: Serum and cerebrospinal fluid (CSF) leptin concentrations during 10 weeks of HFD versus standard diet and exogenous leptin-induced STAT3 phosphorylation in the hypothalamus of minipigs were assessed, and the hypothalamic leptin-sensitive cells were characterized by immunofluorescence.

Results: The efficiency of the passage of endogenous blood-borne leptin into the CSF (measured as the log [CSF:serum leptin ratio]) decreased over time in minipigs fed a HFD (β = -0. Read More

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http://dx.doi.org/10.1002/oby.22465DOI Listing

Bleeding Incidence and Risk Factors among Cancer Patients Treated with Anticoagulation.

Am J Hematol 2019 Apr 21. Epub 2019 Apr 21.

Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.

Compared to age-matched controls, cancer patients have increased risk of bleeding when treated with anticoagulation. However, there are little data regarding bleeding as it relates to anticoagulant choice and other risk factors. We evaluated the 6-month incidence of bleeding among patients treated with anticoagulation and bleeding risk factors. Read More

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http://dx.doi.org/10.1002/ajh.25494DOI Listing

Skin picking in patients with obesity: Associations with impulsiveness and self-harm.

Scand J Psychol 2019 Apr 21. Epub 2019 Apr 21.

Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.

Previous studies suggest elevated prevalence rates of skin picking and self-harm in patients with obesity compared to individuals in the general population. Hence, further studies should investigate prevalence rates and correlates of skin picking in this population - especially its differentiation to self-harm. Skin picking and obesity are both associated with specific facets of impulsiveness. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/sjop.12536
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http://dx.doi.org/10.1111/sjop.12536DOI Listing
April 2019
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Use and interpretation of hemoglobin concentrations for assessing anemia status in individuals and populations: results from a WHO technical meeting.

Ann N Y Acad Sci 2019 Apr 21. Epub 2019 Apr 21.

Evidence and Programme Guidance Unit, Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland.

Anemia is an important public health problem that negatively affects health of individuals and economic potential of populations. An accurate case definition is critical for understanding burden and epidemiology of anemia, for planning public health interventions, and for clinical investigation and treatment of patients. The current threshold hemoglobin concentrations for diagnosis of anemia were proposed in 1968 and based on studies predominantly of Caucasian adult populations in Europe and North America. Read More

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http://dx.doi.org/10.1111/nyas.14090DOI Listing

Resting Energy Expenditure Measured by Indirect Calorimetry in Obese Patients: Variation Within Different BMI Ranges.

JPEN J Parenter Enteral Nutr 2019 Apr 22. Epub 2019 Apr 22.

Nutrition Therapy Multidisciplinary Team/RJ-Clínica São Vicente, Rio de Janeiro, Brazil.

Background: The adequate provision of energy for obese patients by estimation without indirect calorimetry (IC) is challenging. The goal was to establish values of kilocalories per kilogram (kcal/kg) for patients in different ranges of body mass index (BMI [kg/m ]) comparable to resting energy expenditure (REE [kcal/kg/d]) measurements by IC.

Methods: In 63 overweight (OW) hospitalized patients with BMIs (25. Read More

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http://dx.doi.org/10.1002/jpen.1589DOI Listing

Obesity risk in women of childbearing age in New Zealand: a nationally representative cross-sectional study.

Int J Public Health 2019 Apr 22. Epub 2019 Apr 22.

GeoHealth Laboratory (Te Taiwhenua o te Hauora), Geospatial Research Institute (Toi Hangarau), University of Canterbury (Te Whare Wānanga o Waitaha), Christchurch, New Zealand.

Objectives: To investigate risk factors for women with obesity of childbearing age.

Methods: A cross-sectional survey of New Zealand women (15-49 years) with measured height and weight was used [unweighted (n = 3625) and weighted analytical sample (n = 1,098,372)] alongside sociodemographic-, behavioural- and environmental-level predictors. Multilevel logistic regression weighted for non-response of height and weight data was used. Read More

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http://dx.doi.org/10.1007/s00038-019-01239-8DOI Listing

Intermittent Energy Restriction Is a Feasible, Effective, and Acceptable Intervention to Treat Adolescents with Obesity.

J Nutr 2019 Apr 22. Epub 2019 Apr 22.

Children's Hospital at Westmead Clinical School.

Background: Intermittent energy restriction (IER) is an effective obesity management strategy in adults.

Objective: The aim of this study was to investigate the feasibility, effectiveness, and acceptability of IER in adolescents (aged 12-17 y) with obesity [adult equivalent body mass index (BMI; kg/m2) ≥30].

Methods: During weeks 1-12 participants followed an IER dietary plan consisting of a very-low-energy diet (VLED) 3 d/wk (500-600 kcal/d) and an eating plan consistent with national dietary guidelines 4 d/wk. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxz049DOI Listing
April 2019
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Fetal growth retardation and hemorheological predictors of oxygen delivery in hypertensive vs normotensive pregnant women.

Clin Hemorheol Microcirc 2019 Apr 16. Epub 2019 Apr 16.

U1046 INSERM, UMR 9214 CNRS « Physiopathologie & Médecine Expérimentale du Cœur et des Muscles - PHYMEDEXP », Unité d'Explorations Métaboliques (CERAMM), Université de Montpellier, Département de Physiologie Clinique, Hôpital Lapeyronie CHRU Montpellier, France.

Physiological modifications of blood rheology during pregnancy and their alterations in pregnant hypertensive women have been extensively studied in the 1980's. Since vascular resistance is higher in hypertensive pregnant women whose newborns are small-for gestational-age (SGA), we investigated in a personal database if growth retardation of newborns is related to the oxygen delivery index (ratio hematocrit/blood viscosity) and to the difference between hematocrit (Hct) and the prediction of its optimal valued based on Quemada's equation. A sample of 38 hypertensive pregnant women (age 29 yr±1) was compared with 64 controls matched for age and gestational age, studied at 35±1 weeks gestation, extracted from a larger series of 162 pregnant women. Read More

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http://dx.doi.org/10.3233/CH-199002DOI Listing

Sex-related differences in forearm skin microvascular reactivity of young healthy subjects.

Clin Hemorheol Microcirc 2019 Apr 19. Epub 2019 Apr 19.

Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.

Objective: To assess sex-related differences in forearm skin microvascular reactivity to vascular occlusion and cardiovascular health in young healthy women and men.

Methods: 203 young healthy individuals (67 men/136 women) participated in this study. Post-occlusive reactive hyperemia (PORH) in skin microcirculation following 1', 2' and 3' vascular occlusion period was assessed using laser Doppler flowmetry. Read More

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http://dx.doi.org/10.3233/CH-180483DOI Listing

The effect of obesity on pain and disability in chronic shoulder pain patients.

J Back Musculoskelet Rehabil 2019 Apr 11. Epub 2019 Apr 11.

Department of Physical Medicine and Rehabilitation, İzzet Baysal Physical Medicine and Rehabilitation Training and Research Hospital, Bolu, Turkey.

Objective: This study aimed to investigate the relationship between chronic shoulder pain and the increase in BMI.

Methods: A prospective, cross-sectional study design was adopted for the study. Two hundred and eighty-five patients with chronic shoulder pain were evaluated for eligibility. Read More

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http://dx.doi.org/10.3233/BMR-181384DOI Listing

Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development.

Stem Cell Reports 2019 Apr 4. Epub 2019 Apr 4.

Institute for Stem Cell Research, Helmholtz Zentrum München GmbH, 85764 Neuherberg, Germany. Electronic address:

The neural crest (NC) gives rise to a multitude of fetal tissues, and its misregulation is implicated in congenital malformations. Here, we investigated molecular mechanisms pertaining to NC-related symptoms in Bohring-Opitz syndrome (BOS), a developmental disorder linked to mutations in the Polycomb group factor Additional sex combs-like 1 (ASXL1). Genetically edited human pluripotent stem cell lines that were differentiated to NC progenitors and then xenotransplanted into chicken embryos demonstrated an impairment of NC delamination and emigration. Read More

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http://dx.doi.org/10.1016/j.stemcr.2019.03.006DOI Listing