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    Influence of body mass index on postoperative complications after thymectomy in myasthenia gravis patients.
    Oncotarget 2017 Jul 12. Epub 2017 Jul 12.
    Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
    Objectives: It is not clear whether being overweight or obese influences postoperative complications in myasthenia gravis (MG) patients. We retrospectively investigated an association between body mass index (BMI) and postoperative complications in MG.

    Materials And Methods: Fifty-nine MG patients who had undergone transsternal thymectomy were classified as low or high BMI based on the criteria for Asian-Pacific populations. Read More

    Attitudes among transplant professionals regarding shifting paradigms in eligibility criteria for live kidney donation.
    PLoS One 2017 21;12(7):e0181846. Epub 2017 Jul 21.
    Department of Surgery, division of HPB and Transplant Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
    Background: The transplant community increasingly accepts extended criteria live kidney donors, however, great (geographical) differences are present in policies regarding the acceptance of these donors, and guidelines do not offer clarity. The aim of this survey was to reveal these differences and to get an insight in both centre policies as well as personal beliefs of transplant professionals.

    Methods: An online survey was sent to 1128 ESOT-members. Read More

    Placental peptides metabolism and maternal factors as predictors of risk of gestational diabetes in pregnant women. A case-control study.
    PLoS One 2017 21;12(7):e0181613. Epub 2017 Jul 21.
    Department of Molecular Medicine, School of Medical Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
    Background: Gestational diabetes is a risk factor for perinatal complications; include shoulder dystocia, birth injuries such as bone fractures and nerve palsies. It is associated with later development of type 2 diabetes, the risk of macrosomia and other long-term health effects of infants born to diabetic mothers. The study assesses placental peptides and maternal factors as potential predictors of gestational diabetes among pregnant women. Read More

    The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models.
    PLoS One 2017 21;12(7):e0181485. Epub 2017 Jul 21.
    Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.
    Background: The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP. Read More

    Assessment of Weight Loss With the Intragastric Balloon in Patients With different Degrees of Obesity.
    Surg Laparosc Endosc Percutan Tech 2017 Jul 20. Epub 2017 Jul 20.
    *Clinicas Hospital, Bariatric and Metabolic Surgical Unit †Clinicas Hospital, Obesity Unit, Endocrinology, University of São Paulo School of Medicine, São Paulo, Brazil.
    Introduction: The intragastric balloon (IGB) is an endoscopic device for the treatment of obesity. Best results are observed in patients who follow a dietary program but few studies have assessed the results of this treatment in patients with different degrees of obesity.

    Aim: The aim of this study is to compare the efficacy of IGB in patients with different degrees of obesity. Read More

    Renal function and its association with blood pressure in Middle Eastern immigrants and native Swedes.
    J Hypertens 2017 Jul 20. Epub 2017 Jul 20.
    aDepartment of Clinical Sciences bDepartment of Nephrology, Skåne University Hospital, Lund University cDepartment of Family Medicine, Center for Primary Health Care Research, Region Skåne, Skåne University Hospital, Malmö, Sweden.
    Background: Iraqi-born immigrants residing in Sweden are at high risk for type 2 diabetes, obesity and hyperlipidemia compared with native Swedes. Paradoxically, hypertension is less prevalent in this immigrant population. The aim of this study was to investigate differences in renal function and further if differences in blood pressure (BP) levels were associated with differences across ethnicities in renal function as a possible explanation to the paradox. Read More

    Early life exposure to Chinese famine modifies the association between hypertension and cardiovascular disease.
    J Hypertens 2017 Jul 20. Epub 2017 Jul 20.
    aDiscipline of Medicine, University of Adelaide bSouth Australia Medical Research Institute, Adelaide, South Australia cBaker IDI Heart and Diabetes Institute dDepartment of Epidemiology and Preventive Medicine eDepartment of Medicine, Monash University, Melbourne, Victoria, Australia.
    Objective: Studies have shown that famine exposure during early life may increase the risk of cardiovascular disease (CVD), hypertension, and diabetes during adulthood. We aimed to assess whether exposure to the Chinese famine (1959-1961) modifies the association between hypertension and CVD.

    Methods: We investigated data of 5772 adults born between 1954 and 1964 from the China Health and Retirement Longitudinal Study. Read More

    Hormonal factors in the control of the browning of white adipose tissue.
    Horm Mol Biol Clin Investig 2017 Jul 21. Epub 2017 Jul 21.
    Adipose tissue has been historically classified into anabolic white adipose tissue (WAT) and catabolic brown adipose tissue (BAT). Recent studies have revealed the plasticity of WAT, where white adipocytes can be induced into 'brown-like' heat-producing adipocytes (BRITE or beige adipocytes). Recruiting and activating BRITE adipocytes in WAT (so-called 'browning') is believed to provide new avenues for the treatment of obesity-related diseases. Read More

    Outcome by Gender in the Veterans Health Administration Motivating Overweight/Obese Veterans Everywhere Weight Management Program.
    J Womens Health (Larchmt) 2017 Jul 21. Epub 2017 Jul 21.
    2 Center for Health Services Research in Primary Care, Durham VA Medical Center , Durham, North Carolina.
    Background: Few evaluations of the Veterans Health Administration Motivating Overweight/Obese Veterans Everywhere (MOVE!) weight management program have assessed 6-month weight change or factors associated with weight change by gender.

    Materials And Methods: Analysis of administrative data from a national sample of veterans in the VA MOVE!


    Results: A total of 62,882 participants were included, 14.6% were women. Read More

    Effect of Euterpe oleracea Mart. (Açaí) Oil on Dyslipidemia Caused by Cocos nucifera L. Saturated Fat in Wistar Rats.
    J Med Food 2017 Jul 21. Epub 2017 Jul 21.
    1 Drug Research Laboratory, Department of Biological Sciences and Health, College of Pharmacy, Federal University of Amapá , Macapá, Brazil .
    Dyslipidemia is caused by disturbances in lipid metabolism that lead to chronic elevations of serum lipids, especially low-density lipoprotein (LDL)-cholesterol and triglycerides, increasing the risk of metabolic syndrome, obesity, diabetes, atherogenic processes, and cardiovascular diseases. The oil from the fruits of Euterpe oleracea (OFEO) is rich in unsaturated fatty acids with potential for treating alterations in lipid metabolism. In this study, we aimed to investigate the effect of OFEO on hyperlipidemia induced by Cocos nucifera L. Read More

    Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index in a retrospective cohort of children and adolescents who received an allogeneic transplantation in Argentina.
    Arch Argent Pediatr 2017 Aug;115(4):337-342
    Servicio de Trasplante de Médula Ósea del Hospital Garrahan.
    Introduction: Hematopoietic cell transplantationis a therapy with a risk of transplant-related mortality (TRM), which may vary depending on prior comorbidities. The Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) is an instrument developed to measure this risk. There are very few reports on its use in pediatrics. Read More

    Are products sold in university vending machines nutritionally poor? A food environment audit.
    Nutr Diet 2017 Apr 17;74(2):185-190. Epub 2016 Nov 17.
    School of Life and Environmental Sciences, The Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
    Aim: (i) To audit the nutritional composition, promotion and cost of products available from vending machines available to young adults; and (ii) to examine the relationship between product availability and sales.

    Methods: A cross-sectional analysis of snacks and beverages available and purchased at a large urban university was conducted between March and September 2014. Sales were electronically tracked for nine months. Read More

    Dietetic and educational interventions improve clinical outcomes of diabetic and obese clients with mental impairment.
    Nutr Diet 2017 Jul 28;74(3):236-242. Epub 2017 Mar 28.
    Central Adelaide Local Health Network, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
    Aim: The aim of this study was to evaluate the effect of dietetic and educational interventions provided to clients with type 2 diabetes (with or without obesity) or obesity-only residing in supported residential facilities and characterised by mental impairment.

    Methods: A retrospective audit involving the retrieval of information from medical records and databases was undertaken to evaluate the effect of dietetic and educational interventions. Clinical outcomes were weight, body mass index and glycosylated haemoglobin (HbA1c) levels. Read More

    Comparison of malnutrition inflammation score, anthropometry and biochemical parameters in assessing the difference in protein-energy wasting between normal weight and obese patients undergoing haemodialysis.
    Nutr Diet 2017 Jul 12;74(3):283-290. Epub 2017 Apr 12.
    Department of Nephrology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Aim: Protein-energy wasting (PEW) is prevalent in haemodialysis. Obesity is an independent risk factor of kidney insufficiency, but it is proposed to have beneficial roles in better outcomes in the final stage of disease. Better nutritional status and body reserves are among probable mechanisms, but direct examinations are limited. Read More

    Association between anthropometric measures of regional fat mass and heart rate variability in obese women.
    Nutr Diet 2017 Feb 4;74(1):51-60. Epub 2016 Apr 4.
    Department of Endocrinology, Diabetes and Metabolic Disorders, Institute of Internal Disease, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
    Aim: Impaired autonomic function could be the mechanism for the development of cardiometabolic diseases in obesity. Hence, simple anthropometric measures of overall and central obesity could be screening markers for autonomic imbalance. We analysed the relationship between heart rate variability (HRV) parameters and obesity indicators. Read More

    Food provision in early childhood education and care services: Exploring how staff determine nutritional adequacy.
    Nutr Diet 2017 Feb 7;74(1):105-110. Epub 2016 Sep 7.
    School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
    Aim: The aim of this study was to explore the methods, processes and strategies used by early childhood education and care (ECEC) services when determining the nutritional adequacy of food provided to children in their care.

    Methods: Semi-structured interviews (n = 22) were conducted with directors, educators and cooks at long day care services (LDCS) (n = 12) regarding nutritional adequacy, the use of tools, guidelines and checklists, menu planning and identification and management of unhealthy foods. A qualitative thematic approach was used to identify anticipated and emergent themes. Read More

    Sexual health, adherence to Mediterranean diet, body weight, physical activity and mental state: factors correlated to each other.
    Urologia 2017 Jul 14. Epub 2017 Jul 14.
     Azienda Ospedaliero-Universitaria Careggi, Florence - Italy.
    Introduction: Mediterranean diet has shown a protective role against cardiovascular disease, diabetes, cancer onset, microvascular damage and dementia in many trials. Our purpose is the assessment of a correlation between physical activity, Mediterranean diet, body mass index (BMI), depression and erection disorder (ED).

    Methods: After having signed disclaimer to the study participation, we administered the IIEF 15 questionnaire (International Index of Erectil Function), the Hamilton questionnaire for major depression, the Med-Diet Questionnaire, the Ipaq Questionnaire (International Index of Physical Activity) to 245 patients and calculated the BMI. Read More

    Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.
    J Med Chem 2017 Jul 21. Epub 2017 Jul 21.
    Although first-line antidepressants offer therapeutic benefit, about 35% of depressed patients are not adequately treated, creating a large unmet medical need. These medicines mostly enhance the synaptic levels of serotonin and/or norepinephrine. Evidence from preclinical and clinical studies implicate dopamine hypofunction in the pathophysiology of depression. Read More

    Current status of achieving blood pressure target and its clinical correlates in Japanese type 2 diabetes.
    J Diabetes Investig 2017 Jul 21. Epub 2017 Jul 21.
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
    Aims/introduction: To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large-scale cohort of Japanese subjects with type 2 diabetes.

    Materials And Methods: A nationwide survey was conducted including 12,811 subjects with type 2 diabetes. Subjects were divided by achieved blood pressure, <130/80 or 140/90 mmHg, and the number of drug classes taken. Read More

    Glycaemic control and the risk of hospitalisation for infection in patients with type 2 diabetes: Hong Kong Diabetes Registry.
    Diabetes Metab Res Rev 2017 Jul 21. Epub 2017 Jul 21.
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
    Background: Infection occurs more commonly in diabetic compared to general population and is an under-recognised but important morbidity in patients with diabetes. We examined the impact of glycaemic control on hospitalisation for infection in a large prospective cohort of Chinese adults with type 2 diabetes.

    Methods: Between July 1994 and June 2014, 22,846 patients with type 2 diabetes underwent detailed assessment of metabolic control and diabetes complications. Read More

    Psychological assessment of children and adolescents with obesity.
    J Int Med Res 2017 Jan 1:300060517718733. Epub 2017 Jan 1.
    Department of Clinical Nutrition, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Objective This study aimed to analyse the psychological conditions and behaviour of a group of Chinese children and adolescents with obesity, and to develop an intervention for these young patients. Methods A group of 72 patients aged from 4 to 15 years were recruited from an obesity clinic. Patients, or the parents of children younger than 12 years, filled out a series of self-report questionnaires, and the responses were recorded and analysed. Read More

    The effect of very-low-calorie diet on mitochondrial dysfunction in subcutaneous adipose tissue and peripheral monocytes of obese subjects with type 2 diabetes mellitus.
    Physiol Res 2017 Jul 18. Epub 2017 Jul 18.
    Institute of Rheumatology, Prague, Czech Republic; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
    Mitochondrial dysfunction is a potentially important player in the development of insulin resistance and type 2 diabetes mellitus (T2DM). We investigated the changes of mRNA expression of genes encoding main enzymatic complexes of mitochondrial respiratory chain in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) of 11 subjects with simple obesity (OB), 16 obese patients with T2DM and 17 healthy lean subjects (C) before and after very low-calorie diet (VLCD) using quantitative real time PCR. At baseline in SCAT, both T2DM and OB group had decreased mRNA expression of all investigated mitochondrial genes with the exception of 2 complex I (NDUFA12) and complex IV (COX4/1) enzymes in OB subjects. Read More

    Preventive effect of L-carnitine on the disorder of lipid metabolism and circadian cClock of mice subjected to chronic jet-lag.
    Physiol Res 2017 Jul 18. Epub 2017 Jul 18.
    College of Biotechnology and Bioengineering, Zhejiang University of Technology, Zhaohui, Hangzhou, Zhejiang, China.
    Circadian clock plays an essential role in orchestrating daily physiology, and its disruption can evoke metabolic diseases such as obesity. L-Carnitine can reduce blood lipid levels, and ameliorate fatty liver through regulating lipid metabolism. However, whether L-Carnitine administration may affect the disturbance of lipid metabolism and circadian rhythm of mice induced by prolonged circadian disruption is still unknown. Read More

    Inulin-type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight/obesity: a randomized controlled trial.
    Mol Nutr Food Res 2017 Jul 21. Epub 2017 Jul 21.
    General Mills Bell Institute of Health and Nutrition, Golden Valley, USA.
    Scope: Independently, prebiotics and dietary protein have been shown to improve weight loss and/or alter appetite. Our objective was to determine the effect of combined prebiotic and whey protein on appetite, body composition and gut microbiota in adults with overweight/obesity.

    Methods And Results: In a 12 week, placebo-controlled, double-blind study, 125 adults with overweight/obesity were randomly assigned to receive isocaloric snack bars of: 1) Control; 2) Inulin-type fructans (ITF); 3) Whey protein; 4) ITF + Whey protein. Read More

    Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population.
    Pediatr Obes 2017 Jul 20. Epub 2017 Jul 20.
    Division of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
    Introduction: Traffic-related air pollution causes fatty liver, inflammation and fibrosis in animal models, but there have been few studies in humans.

    Objectives: To test the hypothesis that traffic-related air pollution causes non-alcoholic fatty liver disease (NAFLD) and increased markers for non-alcoholic steatohepatitis (NASH); and that NAFLD increases liver susceptibility to increased NASH risk.

    Methods: Data collected prospectively from 74 overweight or obese children were obtained from the Yale Pediatric Obesity Clinic. Read More

    Beneficial long-term antidiabetic actions of N- and C-terminally modified analogues of apelin-13 in diet-induced obese diabetic mice.
    Diabetes Obes Metab 2017 Jul 20. Epub 2017 Jul 20.
    School of Biomedical Sciences, SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Co. Londonderry, BT52 1SA, Northern Ireland, UK.
    Aims: This study investigated the chronic effects of twice daily administration of stable apelin analogues, apelin-13 amide and (pGlu)apelin-13 amide, on metabolic parameters in glucose intolerant and insulin resistant diet-induced obese (DIO) mice fed a high-fat diet for 150 days.

    Study Design & Methods: Groups of mice received twice daily (09:00 and 17:00 h) injections of saline vehicle, apelin-13 amide, (pGlu)apelin-13 amide or exendin-4(1-39) for 28 days (all at 25 nmol/kg). Energy intake, body weight, non-fasting blood glucose, plasma insulin, glucose tolerance, metabolic response to feeding and insulin sensitivity together with pancreatic hormone content and biochemical parameters such as lipids and total GLP-1 were monitored. Read More

    Weighing in on international growth standards: testing the case in Australian preschool children.
    Obes Rev 2017 Jul 21. Epub 2017 Jul 21.
    Institute for Health and Biomedical Innovation, Centre for Children's Health Research, Queensland University of Technology, Brisbane, Queensland, Australia.
    Overweight and obesity in preschool-aged children are major health concerns. Accurate and reliable estimates of prevalence are necessary to direct public health and clinical interventions. There are currently three international growth standards used to determine prevalence of overweight and obesity, each using different methodologies: Center for Disease Control (CDC), World Health Organization (WHO) and International Obesity Task Force (IOTF). Read More

    Higher levels of cardiorespiratory fitness keep liver mitochondria happy!
    J Physiol 2017 Jul 21. Epub 2017 Jul 21.
    Department of Musculoskeletal Biology, Institute of Ageing & Chronic Disease, University of Liverpool, Liverpool, UK.
    The concept that regular physical activity (PA) and exercise training promotes mitochondrial biogenesis in skeletal muscle, enhancing mitochondrial quality and quantity and in doing so increasing oxidative phosphorylation capacity, has been well established for almost 50 years. This article is protected by copyright. All rights reserved. Read More

    Overweight but unseen: a review of the underestimation of weight status and a visual normalization theory.
    Obes Rev 2017 Jul 21. Epub 2017 Jul 21.
    Department of Psychological Sciences, University of Liverpool, Liverpool, UK.
    Although overweight and obesity are widespread across most of the developed world, a considerable body of research has now accumulated, which suggests that adiposity often goes undetected. A substantial proportion of individuals with overweight or obesity do not identify they are overweight, and large numbers of parents of children with overweight or obesity fail to identify their child as being overweight. Lay people and medical practitioners are also now poor at identifying overweight and obesity in others. Read More

    Blunted cerebral vascular responsiveness to hypercapnia in obese individuals.
    Exp Physiol 2017 Jul 21. Epub 2017 Jul 21.
    Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX.
    Obesity increases the risk of cardiovascular disease (CVD) by more than 45%. Furthermore, obesity is a contributing factor for cognitive impairment and Alzheimer disease. The mechanisms accounting for this increased disease risk have not been clarified. Read More

    Genetics in an isolated population like Finland: a different basis for genomic medicine?
    J Community Genet 2017 Jul 20. Epub 2017 Jul 20.
    National Institute for Health and Welfare, Helsinki, Finland.
    A unique genetic background in an isolated population like that of Finland offers special opportunities for genetic research as well as for applying the genetic developments to the health care. On the other hand, the different genetic background may require local attempts to develop diagnostics and treatment as the selection of diseases and mutations differs from that in the other populations. In this review, we describe the experiences of research and health care in this genetic isolate starting from the identification of specific monogenic diseases enriched in the Finnish population all the way to implementing the knowledge of the unique genetic background to genomic medicine at population level. Read More

    Transplantation sites for porcine islets.
    Diabetologia 2017 Jul 21. Epub 2017 Jul 21.
    National Pancreas and Islet Transplant Unit, University of Sydney, Westmead Hospital, Sydney, NSW, Australia.
    Aims/hypothesis: Xenotransplantation has great potential to provide beta cell replacement and thereby provide a cure for large numbers of people with type 1 diabetes. Crucial to the success of xenotransplantation is establishment of the most viable sites for transplantation.

    Methods: We compared porcine islet tissue transplanted into kidney, liver and spleen in pig recipients as assessed by blood glucose levels and IVGTT. Read More

    Phosphoproteomic Analysis of Isolated Mitochondria in Yeast.
    Methods Mol Biol 2017 ;1636:283-299
    UMR 9198 CNRS, Institute for Integrative Biology of the Cell (I2BC), B3S, LPSM-CEA Saclay, 91191, Gif-sur-Yvette cedex, France.
    Mitochondria play a central role in cellular energy metabolism and cell death. Deregulation of mitochondrial functions is associated with several human pathologies (neurodegenerative diseases, neuromuscular diseases, type II diabetes, obesity, cancer). The steadily increasing number of identified mitochondrial phosphoproteins, kinases, and phosphatases in recent years suggests that reversible protein phosphorylation plays an important part in the control of mitochondrial processes. Read More

    The intriguing connections of leptin to hyperparathyroidism.
    Endocrine 2017 Jul 20. Epub 2017 Jul 20.
    Section of Specialized Endocrinology, Medical Clinic B, Oslo University Hospital, Oslo, Norway.
    Purpose: Leptin has been implicated in bone metabolism, but the association with parathyroid gland function has not been fully clarified. This review aimed to summarize evidence of the association between leptin and hyperparathyroidism, both primary and secondary, elucidating the potential pathophysiologic and therapeutic consequences between leptin and parathyroid hormone, hopefully prompting the design of new studies.

    Results: Experimental studies indicate a positive loop between leptin and parathyroid hormone in primary hyperparathyroidism. Read More

    Nutritional Counseling for Obese Children with Obesity-Related Metabolic Abnormalities in Korea.
    Pediatr Gastroenterol Hepatol Nutr 2017 Jun 28;20(2):71-78. Epub 2017 Jun 28.
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Jeju National University Hospital, Jeju, Korea.
    Child obesity has become a significant health issue in Korea. Prevalence of obesity in school-age children in Korea has been alarmingly rising since 2008. Prevalence of obesity among infants and preschool-age children in Korea has doubled since 2008. Read More

    Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function.
    Front Endocrinol (Lausanne) 2017 3;8:143. Epub 2017 Jul 3.
    Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy.
    Glucose homeostasis is finely regulated by a number of hormones and peptides released mainly from the brain, gastrointestinal tract, and muscle, regulating pancreatic secretion through cellular receptors and their signal transduction cascades. The endocrine function of the pancreas is controlled by islets within the exocrine pancreatic tissue that release hormones like insulin, glucagon, somatostatin, pancreatic polypeptide, and ghrelin. Moreover, both exocrine and endocrine pancreatic functions are regulated by a variety of hormonal and neural mechanisms, such as ghrelin, glucagon-like peptide, glucose-dependent insulinotropic polypeptide, or the inhibitory peptide somatostatin. Read More

    Oxygen-induced impairment in arterial function is corrected by slow breathing in patients with type 1 diabetes.
    Sci Rep 2017 Jul 20;7(1):6001. Epub 2017 Jul 20.
    Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Helsinki, Finland.
    Hyperoxia and slow breathing acutely improve autonomic function in type-1 diabetes. However, their effects on arterial function may reveal different mechanisms, perhaps potentially useful. To test the effects of oxygen and slow breathing we measured arterial function (augmentation index, pulse wave velocity), baroreflex sensitivity (BRS) and oxygen saturation (SAT), during spontaneous and slow breathing (6 breaths/min), in normoxia and hyperoxia (5 L/min oxygen) in 91 type-1 diabetic and 40 age-matched control participants. Read More

    STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance.
    Endocr Relat Cancer 2017 Aug;24(8):415-426
    Department of Cellular and Molecular MedicineLerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Leptin (LEP) binds to the long form of the leptin receptor (LEPRb), leading to the activation of multiple signaling pathways that are potential targets for disrupting the obesity-breast cancer link. In triple-negative breast cancer (TNBC), LEP is hypothesized to predominantly mediate its tumorigenic effects via a subpopulation of LEPRb-positive tumor cells termed cancer stem cells (CSCs) that can initiate tumors and induce tumor progression. Previously, we showed that LEP promotes CSC survival in vivo Moreover, silencing LEPRb in TNBC cells compromised the CSC state. Read More

    Recognized Obstructive Sleep Apnea is Associated With Improved In-Hospital Outcomes After ST Elevation Myocardial Infarction.
    J Am Heart Assoc 2017 Jul 20;6(7). Epub 2017 Jul 20.
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH
    Background: Obstructive sleep apnea (OSA) is an independent risk factor for many cardiovascular conditions such as coronary artery disease, myocardial infarction, systemic hypertension, pulmonary hypertension, and stroke. However, the association of OSA with outcomes in patients hospitalized for ST-elevation myocardial infarction remains controversial.

    Methods And Results: We used the nation-wide inpatient sample between 2003 and 2011 to identify patients with a primary discharge diagnosis of ST-elevation myocardial infarction and then used the International Classification of Diseases, Clinical Modification code 327. Read More

    Body fat of rats of different age-groups and nutritional states: assessment by micro-CT and skinfold thickness.
    J Appl Physiol (1985) 2017 Jul 20:jap.00884.2016. Epub 2017 Jul 20.
    University of Pecs, Medical School
    Obesity presents a growing public health problem. Therefore, the analysis of body composition is important in clinical practice as well as in animal research models of obesity, hence precise methods for the assessment of body fat would be essential. We aimed to evaluate in vivo abdominal micro-computed tomography scan restricted to the L1-L3 region (micro-CT(L1-L3)), a skinfold thickness-based method (STM) and post mortem body composition analysis (PMA) with regard to whole-body micro-CT scan in rats. Read More

    Severe energy deficit up-regulates leptin receptors, leptin signaling and PTP1B in human skeletal muscle.
    J Appl Physiol (1985) 2017 Jul 20:jap.00454.2017. Epub 2017 Jul 20.
    University of Las Palmas de Gran Canaria
    In obesity, leptin receptors (OBR) and leptin signaling in skeletal muscle are down-regulated. To determine whether OBR and leptin signaling are up-regulated with a severe energy deficit fifteen overweight men were assessed before (PRE), after 4 days of caloric restriction (3.2 Kcal/kg BW/day) in combination with prolonged exercise (CRE) (8h walking + 45min single-arm cranking/day) to induce an energy deficit of ~5500 Kcal/d, and following 3 days of control diet (isoenergetic) and reduced exercise (CD). Read More

    Dietary intake and factors influencing eating behaviours in overweight and obese South Asian men living in the UK: mixed method study.
    BMJ Open 2017 Jul 20;7(7):e016919. Epub 2017 Jul 20.
    School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
    Objective: It is widely recognised that South Asian men living in the UK are more likely to develop type 2 diabetes mellitus (T2DM) than their white British counterparts. Despite this, limited data have been published quantifying current dietary intake patterns and qualitatively exploring eating behaviours in this population. The objectives of this study were to (1) assess diet, (2) explore perceptions of T2DM, (3) investigate factors influencing eating behaviours in overweight/obese South Asian men and (4) determine the suitability of the UK Diet and Diabetes Questionnaire (UKDDQ) for use in this population. Read More

    Elevated Cardiovascular Disease Risk in Patients With Chronic Myelogenous Leukemia Seen in Community-based Oncology Practices in the United States.
    Clin Lymphoma Myeloma Leuk 2017 Jun 17. Epub 2017 Jun 17.
    Department of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN.
    Introduction: Current National Comprehensive Cancer Network guidelines recommend that comorbidities, including cardiovascular disease (CVD), be considered when selecting tyrosine kinase inhibitors for the treatment of chronic myelogenous leukemia (CML). We report here the prevalence of CVD and its risk factors in patients with CML treated by community-based United States (US) oncologists.

    Patients And Methods: Adult patients with a confirmed diagnosis of CML and ≥ 1 encounter after the first date of CML diagnosis in an electronic medical record database between January 1, 2005 and October 31, 2014 were enrolled. Read More

    Ascorbic acid supplementation partially prevents the delayed reproductive development in juvenile male rats exposed to rosuvastatin since prepuberty.
    Reprod Toxicol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Morphology, São Paulo State University (Unesp), Institute of Biosciences, Botucatu, Brazil.
    Dyslipidemias are occurring earlier in the population due to the increase of obesity and bad eating habits. Rosuvastatin inhibits the enzyme HMG-CoA reductase, decreasing total cholesterol. Ascorbic acid is an important antioxidant compound for male reproductive system. Read More

    Antenatal antipsychotic exposure induces multigenerational and gender-specific programming of adiposity and glucose tolerance in adult mouse offspring.
    Diabetes Metab 2017 Jul 17. Epub 2017 Jul 17.
    Inserm, Saint-Antoine Research Center, Saint-Antoine Hospital, Sorbonne University, Pierre-and-Marie-Curie University Paris 06, 75012 Paris, France; Hospitalo-Universitary Institute, ICAN, 75013 Paris, France; Department of Endocrinology, Saint-Antoine Hospital, AP-HP, 75012 Paris, France. Electronic address:
    Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring. Read More

    [Long-term effects of intensive intervention on changes in lifestyle in patients with hyperfibrinogenaemia and moderate-high cardiovascular risk].
    Aten Primaria 2017 Jul 17. Epub 2017 Jul 17.
    EAP Sardenya, Barcelona, España.
    Objectives: To determine whether the benefit on cardiovascular risk factors (CVRF) persists 5 years after an intensive intervention in lifestyle (LS) that lasted 2 years, in patients with hyperfibrinogenaemia and moderate or high cardiovascular risk.

    Design: multicentre prospective observational study.

    Location: 13 Primary Care Centres in Barcelona and Baix Llobregat. Read More

    Evidence that Children Born at Early Term (37-38-6/7 weeks) Are at Increased Risk for Diabetes and Obesity-related Disorders.
    Am J Obstet Gynecol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Background: Prematurity is known to be associated with high rates of endocrine and metabolic complications in the offspring. Early term (37 0/7-38 6/7 weeks' gestation) born offspring were also shown to exhibit long term morbidity resembling that of late preterm, in several health categories.

    Objective: We aimed to determine whether early term delivery impacts on the long-term endocrine and metabolic health of the offspring. Read More

    Serum Galectin-1 Levels are Positively Correlated with Body Fat and Negatively with Fasting Glucose in Obese Children.
    Peptides 2017 Jul 17. Epub 2017 Jul 17.
    Division of Pediatric Endocrinology, Dokuz Eylul University School of Medicine, Izmir, Turkey. Electronic address:
    Galectin-1, a recently identified peptide, is primarily released from the adipose tissue. Although galectin-1 was shown to have an anti-inflammatory effect, its specific function is not clearly understood. We aimed to evaluate the relationship of serum galectin-1 levels with clinical and laboratory parameters in childhood obesity. Read More

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