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    (p-ClPhSe)2 Reduces Hepatotoxicity Induced by Monosodium Glutamate by Improving Mitochondrial Function in Rats.
    J Cell Biochem 2017 Feb 18. Epub 2017 Feb 18.
    Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
    It is has been demonstrated that mitochondrial dysfunction, oxidative stress and chronic inflammatory process are associated with progress of morbid obesity in human patients. For this reason, the searching for safe and effective antiobesity drugs has been the subject of intense research. In this context, the organic selenium compounds have attracted much attention due to their pharmacological properties, such as antihyperglycemic, antioxidant and anti-inflammatory. Read More

    AA amyloidosis is an emerging cause of nephropathy in obese patients.
    Eur J Intern Med 2017 Feb 14. Epub 2017 Feb 14.
    Assistance publique-hôpitaux de Paris, hôpital Tenon, Centre de référence adulte des amyloses d'origine inflammatoire et de la fièvre méditerranéenne familiale (CERAIF), service de médecine interne, F-75020 Paris, France; Sorbonne Universités, UPMC Université Paris 06, Département hospitalo-universitaire I2B, F-75013 Paris, France; Sorbonne Université, UPMC université Paris 06, INSERM UMR_933, F-75012 Paris, France.

    Characteristics of patients with liver cancer in the BioBank Japan project.
    J Epidemiol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. Electronic address:
    Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies.

    Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Read More

    Protective Misperception? Prospective Study of Weight Self-Perception and Blood Pressure in Adolescents With Overweight and Obesity.
    J Adolesc Health 2017 Feb 14. Epub 2017 Feb 14.
    Division of Adolescent/Young Adult Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
    Purpose: Underestimating one's weight is often seen as a barrier to weight loss. However, recent research has shown that weight underperception may be beneficial, with lower future weight gain and fewer depressive symptoms. Here, we examine the relationship between adolescent weight underperception and future blood pressure. Read More

    Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation.
    Trends Endocrinol Metab 2017 Feb 14. Epub 2017 Feb 14.
    Department of Internal Medicine I, Gastroenterology, Hepatology & Endocrinology and Christian Doppler Laboratory for Mucosal Immunology, Medical University Innsbruck, Innsbruck, Austria. Electronic address:
    Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is released by various cell types and is an attractive biomarker of inflammation, ischemia, infection, and kidney damage. Both intestinal and metabolic inflammation, as observed in obesity and related disorders, are associated with increased LCN2 synthesis. While LCN2 in the intestinal tract regulates the composition of the gut microbiota and shows anti-inflammatory activities, it also exhibits proinflammatory activities in other experimental settings. Read More

    'I just want to be normal' - A qualitative study of pregnant women's blogs who present themselves as overweight or obese.
    Midwifery 2017 Jan 31. Epub 2017 Jan 31.
    Department of Medical and Health Sciences, Linköping University, SE 581 83 Linköping, Sweden. Electronic address:
    Objective: to describe what pregnant women who present themselves as overweight or obese write about their pregnancy in their blogs.

    Setting: Swedish private blogs.

    Design: a qualitative study, using 13 Internet blogs as the source of data. Read More

    Why intensity is not a bad word: Optimizing health status at any age.
    Clin Nutr 2017 Feb 9. Epub 2017 Feb 9.
    Department of Human Studies, University of Alabama at Birmingham, USA; Department of Nutrition Sciences, University of Alabama at Birmingham, USA.
    Age-related declines in health and function make locomotion increasingly difficult leading to reductions in non-exercise activity thermogenesis (NEAT), skeletal muscle size and strength, and increased adiposity. Exercise is an important strategy to attenuate loss of function through the life cycle. Despite claims to the contrary, high-intensity exercise is important for the prevention of obesity and sarcopenia with advancing age. Read More

    Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial: Arabinoxylans in gut barrier.
    Clin Nutr 2017 Feb 3. Epub 2017 Feb 3.
    Department of Internal Medicine, Division of Gastroenterology-Hepatology, School of Nutrition & Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.
    Background & Aims: Obesity and metabolic diseases are associated with alterations in microbial composition and impaired gut barrier. Previous in vitro and animal studies have shown that arabinoxylans (AX) have the potential to modulate gut microbiota and gut barrier and therefore could have a protective role. Primary aim of the study was to investigate the effect of AX on intestinal permeability. Read More

    Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents.
    J Hepatol 2017 Feb 6. Epub 2017 Feb 6.
    Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom.
    Background & Aims: Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alcoholic steatohepatitis (NASH). Read More

    Epidemiology of stone disease across the world.
    World J Urol 2017 Feb 17. Epub 2017 Feb 17.
    Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.
    Nephrolithiasis is a highly prevalent disease worldwide with rates ranging from 7 to 13% in North America, 5-9% in Europe, and 1-5% in Asia. Due to high rates of new and recurrent stones, management of stones is expensive and the disease has a high level of acute and chronic morbidity. The goal of this study is to review the epidemiology of stone disease in order to improve patient care. Read More

    First experiences with neuropsychological effects of oxytocin administration in childhood-onset craniopharyngioma.
    Endocrine 2017 Feb 17. Epub 2017 Feb 17.
    Department of Pediatrics and Pediatric Hematology / Oncology, Klinikum Oldenburg AöR, Medical Campus University Oldenburg, Oldenburg, 26133, Germany.
    Purpose: The hypothalamic hormone oxytocin plays a major role in regulation of behavior and body composition. Quality of survival is frequently impaired in childhood craniopharyngioma patients due to sequelae such as behavioral deficits and severe obesity caused by tumor or treatment-related hypothalamic lesions.

    Methods: In our pilot cross-sectional study, we analyzed emotion recognition abilities and oxytocin concentrations in saliva and urine before and after single nasal administration of 24 IU oxytocin in 10 craniopharyngioma patients. Read More

    Pedagogical Approaches to and Effects of Fundamental Movement Skill Interventions on Health Outcomes: A Systematic Review.
    Sports Med 2017 Feb 18. Epub 2017 Feb 18.
    Faculty of Health Sciences, Exercise and Sport Sciences, The University of Sydney, Cumberland Campus, 75 East St, Lidcombe, NSW, 2141, Australia.
    Background: Fundamental movement skills (FMS) are assumed to be the basic prerequisite motor movements underpinning coordination of more integrated and advanced movement capabilities. FMS development and interventions have been associated with several beneficial health outcomes in individual studies.

    Objective: The primary aim of this review was to identify FMS intervention characteristics that could be optimised to attain beneficial outcomes in children and adolescents, while the secondary aim was to update the evidence as to the efficacy of FMS interventions on physiological, psychological and behavioural health outcomes. Read More

    Quality of life improves in children and adolescents during a community-based overweight and obesity treatment.
    Qual Life Res 2017 Feb 17. Epub 2017 Feb 17.
    Department of Paediatrics, The Children's Obesity Clinic, Copenhagen University Hospital Holbæk, Smedelundsgade 60, 4300, Holbæk, Denmark.
    Purpose: The quality of life is compromised in children and adolescents with overweight or obesity. The aim of this study was to evaluate whether the quality of life improves during a community-based overweight and obesity treatment, and whether improvements depend on reductions in the degree of obesity.

    Methods: Quality of life was assessed using the Pediatric Quality of Life Inventory (PedsQL) 4. Read More

    Patterns of Abnormal Gastric Pacemaking After Sleeve Gastrectomy Defined by Laparoscopic High-Resolution Electrical Mapping.
    Obes Surg 2017 Feb 17. Epub 2017 Feb 17.
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
    Background: Laparoscopic sleeve gastrectomy (LSG) is increasingly being applied to treat obesity. LSG includes excision of the normal gastric pacemaker, which could induce electrical dysrhythmias impacting on post-operative symptoms and recovery, but these implications have not been adequately investigated. This study aimed to define the effects of LSG on gastric slow-wave pacemaking using laparoscopic high-resolution (HR) electrical mapping. Read More

    Preventing Weight Gain Improves Sleep Quality Among Black Women: Results from a RCT.
    Ann Behav Med 2017 Feb 17. Epub 2017 Feb 17.
    Duke Global Digital Health Science Center, Duke Global Health Institute, 310 Trent Drive, Box 90519, Durham, NC, 27710, USA.
    Background: Obesity and poor sleep are highly prevalent among Black women.

    Purpose: We examined whether a weight gain prevention intervention improved sleep among Black women.

    Methods: We conducted a randomized trial comparing a 12-month weight gain prevention intervention that included self-monitoring through mobile technologies and phone coaching to usual care in community health centers. Read More

    Destroying God's Temple? Physical Inactivity, Poor Diet, Obesity, and Other "Sin" Behaviors.
    J Relig Health 2017 Feb 17. Epub 2017 Feb 17.
    Department of Kinesiology and Health Science, Stephen F. Austin State University, Nacogdoches, TX, USA.
    On average, our participants (N = 112), who self-proclaimed to be Christians, believed that physically inactive lifestyles, unhealthy eating, overeating, and being obese destroy the body, God's temple. However, these beliefs were less definitive, than those of other common "sin" behaviors, such as drug use, smoking, and excessive drinking of alcohol. In addition, destroying the body with physical inactivity or poor diet was not necessarily viewed as sinful. Read More

    An ATF4/ATG5 Signaling in Hypothalamic POMC Neurons Regulates Fat Mass via Affecting Energy Expenditure.
    Diabetes 2017 Feb 17. Epub 2017 Feb 17.
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
    Although many biological functions of activating transcription factor 4 (ATF4) have been identified, a role of hypothalamic ATF4 in the regulation of energy homeostasis is poorly understood. Here, we showed that hypothalamic pro-opiomelanocortin (POMC) neurons specific ATF4 knockout (PAKO) mice are lean and have higher energy expenditure. Furthermore, PAKO mice were resistant to high-fat diet (HFD)-induced obesity, glucose intolerance and leptin resistance. Read More

    FoxO integration of insulin signaling with glucose and lipid metabolism.
    J Endocrinol 2017 Feb 17. Epub 2017 Feb 17.
    H Dong, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, United States
    The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the amino DNA binding domain, known as "forkhead box" domain. They mediate the inhibitory action of insulin or insulin-like growth factor on key functions involved in cell metabolism, growth, differentiation, oxidative stress, senescence, autophagy and aging. Read More

    Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice.
    Eur J Pharmacol 2017 Feb 14. Epub 2017 Feb 14.
    College of Pharmacy, Woosuk University, Wanju-gun, Jeollabuk-do, Republic of Korea. Electronic address:
    Adipose tissue inflammation and oxidative stress are key components in the development of obesity and insulin resistance. Heme oxygenase (HO)-1 in adipocytes protects against obesity and adipose dysfunction. In this study, we report the identification of butein, a flavonoid chalcone, as a novel inducer of HO-1 expression in adipocytes in vitro and in vivo. Read More

    Respiratory load perception in overweight and asthmatic children.
    Respir Physiol Neurobiol 2017 Feb 14. Epub 2017 Feb 14.
    Division of Asthma, Allergy & Lung Biology, King's College London Department of Respiratory Medicine, Bessemer Road, London SE5 9PJ, United Kingdom. Electronic address:
    Overweight asthmatic children report greater symptoms than normal weight asthmatics, despite comparable airflow obstruction. This has been widely assumed to be due to heightened perception of respiratory effort. Three groups of children (healthy weight controls, healthy weight asthmatics, overweight asthmatics) rated perceived respiratory effort throughout an inspiratory resistive loading protocol. Read More

    Cardiovascular risk in different obesity phenotypes over a decade follow-up: Tehran Lipid and Glucose Study.
    Atherosclerosis 2017 Feb 3;258:65-71. Epub 2017 Feb 3.
    Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran. Electronic address:
    Background And Aims: Considering the inconsistent data available on cardiovascular (CV) risk of different obesity phenotypes, the aim of this study was to investigate the development of cardiovascular disease (CVD) in different obesity phenotypes over a median follow-up of 12 years.

    Methods: In this large population-based cohort, 7842 participants (44.8% men), aged ≥ 30 years, were enrolled. Read More

    Diet-induced obesity, gut microbiota and bone, including alveolar bone loss.
    Arch Oral Biol 2017 Feb 7;78:65-81. Epub 2017 Feb 7.
    Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 5020, Thailand. Electronic address:
    Obesity is a major risk factor for several pathologies, including jaw bone resorption. The underlying mechanisms involved in pathological conditions resulting from obesity include chronic systemic inflammation and the development of insulin resistance. Although numerous studies have indicated the importance of the role of gut microbiota in the pathogenesis of inflammation and insulin resistance in obesity, only a few studies have established a relationship between obesity, gut microbiota and status of the jaw bone. Read More

    Prediction of Cesarean Delivery in the Term Nulliparous Woman: Results from the Prospective Multi-center Genesis Study.
    Am J Obstet Gynecol 2017 Feb 14. Epub 2017 Feb 14.
    Royal College of Surgeons in Ireland, Rotunda Hospital, Dublin, Ireland.
    Background: In contemporary practice many nulliparous women require intervention during childbirth such as operative vaginal delivery or Cesarean delivery (CD). Despite the knowledge that the rising CD rate is associated with increasing maternal age, obesity and larger infant birthweight, we lack a reliable method to predict the requirement for such potentially hazardous obstetric procedures during labor and delivery. This issue is important as there are higher rates of morbidity and mortality associated with unplanned CD performed in labor compared to scheduled Cesarean deliveries. Read More

    The pathogenesis and pathophysiology of gestational diabetes mellitus: Deductions from a three-part longitudinal metabolomics study in China.
    Clin Chim Acta 2017 Feb 14. Epub 2017 Feb 14.
    Mass Spectrometry Centre, China-Canada-New Zealand Joint Laboratory of Maternal and Foetal Medicine, Chongqing Medical University, Chongqing, China; Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Gestational diabetes mellitus (GDM) is a form of diabetes that is first recognised during pregnancy, with no evidence of pre-existing type 1 or type 2 diabetes. The prevalence of GDM has been rising steadily over the past few decades, coinciding with the ongoing epidemic of obesity and type 2 diabetes. Although GDM normally disappears after delivery, women who have been previously diagnosed with GDM are at a greater risk of developing gestational diabetes in subsequent pregnancies, and type 2 diabetes later in life. Read More

    Obesity is associated with long-term improved survival in definitively treated locally advanced non-small cell lung cancer (NSCLC).
    Lung Cancer 2017 Feb 1;104:52-57. Epub 2016 Dec 1.
    University of Maryland Greenebaum Cancer Center, Baltimore, MD, United States. Electronic address:
    Objectives: To determine the prognostic effect of Body Mass Index (BMI) in definitively treated locally advanced NSCLC patients.

    Materials And Methods: In this single institution retrospective cohort study, we evaluated 291 patients who were treated for locally advanced NSCLC from 2000 to 2010. They were stratified into four BMI groups based on World Health Organization criteria: underweight (<18. Read More

    Costs and Outcomes of Increasing Access to Bariatric Surgery: Cohort Study and Cost-Effectiveness Analysis Using Electronic Health Records.
    Value Health 2017 Jan 21;20(1):85-92. Epub 2016 Oct 21.
    Department of Social Policy, London School of Economics and Political Science, London, UK.
    Objectives: To estimate costs and outcomes of increasing access to bariatric surgery in obese adults and in population subgroups of age, sex, deprivation, comorbidity, and obesity category.

    Methods: A cohort study was conducted using primary care electronic health records, with linked hospital utilization data, for 3,045 participants who underwent bariatric surgery and 247,537 participants who did not undergo bariatric surgery. Epidemiological analyses informed a probabilistic Markov model to compare bariatric surgery, including equal proportions with adjustable gastric banding, gastric bypass, and sleeve gastrectomy, with standard nonsurgical management of obesity. Read More

    The Burden of Obesity on Diabetes in the United States: Medical Expenditure Panel Survey, 2008 to 2012.
    Value Health 2017 Jan 4;20(1):77-84. Epub 2016 Nov 4.
    Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA. Electronic address:
    Background: Diabetes is one of the most prevalent and costly chronic diseases in the United States.

    Objectives: To analyze the risk of developing diabetes and the annual cost of diabetes for a US general population.

    Methods: Data from the Medical Expenditure Panel Survey, 2008 to 2012, were used to analyze 1) probabilities of developing diabetes and 2) annual total health care expenditures for diabetics. Read More

    Molecular recognition between pancreatic lipase and natural and synthetic inhibitors.
    Int J Biol Macromol 2017 Feb 14. Epub 2017 Feb 14.
    Laboratorio de Modelado Molecular, Bioinformática y Diseño de Fármacos de la Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Diaz Mirón S/N, Col. Casco de Santo Tomas, México City, CP: 11340, Mexico.
    Pancreatic lipase (PL) is a primary lipase critical for triacylglyceride digestion in humans and is considered as a promising target for the treatment of obesity. Although the current synthetic drugs available for treating obesity have been demonstrated to be effective in inhibiting PL, their prolonged usage results in severe side effects. Based on this argument, in this study, we evaluated the structural and energetic features linked to molecular recognition between two well-known PL inhibitors, orlistat (ORL, synthetic inhibitor) and (-)-epigallocatechin gallate (EGCG, natural inhibitor) and PL through molecular dynamics simulations and free energy calculations of ORL and EGCG at the PL binding site when it is isolated (PL) from the heterodimer complex, forming the heterodimer complex with colipase (PLCL) and lacking structural calcium. Read More

    Longitudinal associations between maternal feeding and overweight in low-income toddlers.
    Appetite 2017 Feb 14. Epub 2017 Feb 14.
    Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, MI, USA.
    Maternal feeding is a frequent intervention target for the prevention of early childhood obesity but longitudinal associations between feeding and child overweight are poorly understood. This observational cohort study sought to examine the cross-lagged associations between maternal feeding and overweight across ages 21, 27, and 33 months. Feeding was measured by maternal self-report (n = 222) at each age. Read More

    Calcium Channels in Vascular Smooth Muscle.
    Adv Pharmacol 2017 14;78:49-87. Epub 2016 Oct 14.
    University of California, Davis, CA, United States. Electronic address:
    Calcium (Ca(2+)) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca(2+) concentration ([Ca(2+)]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca(2+)-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca(2+)]i. Read More

    CTRP1 in Liver Disease.
    Adv Clin Chem 2017 1;79:1-23. Epub 2016 Dec 1.
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address:
    Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease occurs in significant percentage of general population. NAFLD is closely associated with entire spectrum of metabolic-related disorders including diabetes, obesity, and cardiovascular diseases. Considering several similar pathways underpinning metabolic disorders, presence of common molecular mediators contributing to pathomechanism of these disorders is expected. Read More

    Validity of a simplified screening instrument for assessing overweight children in a dental setting: a cross sectional study.
    BMC Pediatr 2017 Feb 17;17(1):56. Epub 2017 Feb 17.
    Faculty of Dentistry, University of Toronto, 710F-481 University Ave, Toronto, ON, M5G 2P1, Canada.
    Background: Obesity, with its rising prevalence among Canadians and its estimated cost of $2 billion annually in Canada, is no longer considered a cosmetic issue, but a major health issue that imposes a great burden on the healthcare system and economy. This cross sectional study aims to evaluate the feasibility of identifying the weight status of 6 to 11 year-old children in a university dental clinic using a simplified overweight screening instrument.

    Methods: One hundred sixty eight healthy children were enrolled. Read More

    Proportion of dementia in Australia explained by common modifiable risk factors.
    Alzheimers Res Ther 2017 Feb 17;9(1):11. Epub 2017 Feb 17.
    Centre for Research on Ageing, Health and Wellbeing, The Australian National University, Florey, Building 54, Mills Road, Acton, ACT 2601, Australia.
    Background: At present, dementia has no known cure. Interventions to delay onset and reduce prevalence of the disease are therefore focused on risk factor reduction. Previous population attributable risk estimates for western countries may have been underestimated as a result of the relatively low rates of midlife obesity and the lower weighting given to that variable in statistical models. Read More

    An adaptive variant of TRIB2, rs1057001, is associated with higher expression levels of thermogenic genes in human subcutaneous and visceral adipose tissues.
    J Physiol Anthropol 2017 Feb 17;36(1):16. Epub 2017 Feb 17.
    Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, 329-0498, Japan.
    Background: An obesity-related single-nucleotide polymorphism (SNP) of the Tribbles pseudokinase 2 gene (TRIB2) was shown to have underwent adaptive evolution in the last glacial period, suggesting a selective advantage of this SNP in human populations in cold environments. In order to verify this hypothesis, the effect of the TRIB2 SNP on the expression of genes involved in adaptive thermogenesis was tested using messenger RNAs prepared from adipose tissues of Japanese adults.

    Methods: Complementary DNA was prepared from subcutaneous adipose tissues (SAT) and visceral adipose tissues (VAT) obtained from 48 Japanese adults. Read More

    Erectile dysfunction and exposure to ambient Air pollution in a nationally representative cohort of older Men.
    Environ Health 2017 Feb 17;16(1):12. Epub 2017 Feb 17.
    Department of Civil and Environmental Engineering, Tufts University, 200 College Avenue, 301 Anderson Hall, Medford, MA, 02155, USA.
    Background: Little is known about the association between air pollution and erectile dysfunction (ED), a disorder occurring in 64% of men over the age of 70, and to date, no studies have been published. To address this significant knowledge gap, we explored the relationship between ED and air pollution in a group of older men who were part of the National Social Life, Health, and Aging Project (NSHAP), a nationally representative cohort study of older Americans.

    Methods: We obtained incident ED status and participant data for 412 men (age 57-85). Read More

    Alcoholic, Nonalcoholic, and Toxicant-Associated Steatohepatitis: Mechanistic Similarities and Differences.
    Cell Mol Gastroenterol Hepatol 2015 Jul 3;1(4):356-367. Epub 2015 Jun 3.
    Division of Gastroenterology, Hepatology and Nutrition, School of Medicine, University of Louisville, Louisville, Kentucky; Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, Kentucky; Robley Rex Veterans Affairs Medical Center, Louisville, Kentucky.
    Hepatic steatosis and steatohepatitis are common histologic findings that can be caused by multiple etiologies. The three most frequent causes for steatosis/steatohepatitis are alcohol (alcoholic steatohepatitis, ASH), obesity/metabolic syndrome (nonalcoholic steatohepatitis, NASH), and environmental toxicants (toxicant-associated steatohepatitis, TASH). Hepatic steatosis is an early occurrence in all three forms of liver disease, and they often share common pathways to disease progression/severity. Read More

    Can you feel the body that you see? On the relationship between interoceptive accuracy and body image.
    Body Image 2017 Feb 14;20:130-136. Epub 2017 Feb 14.
    Lab of Action & Body, Department of Psychology, Royal Holloway, University of London, TW20 0EX Egham, Surrey, UK.
    Interoception and exteroception for body signals are two different ways of perceiving the self: the first from within, the second from outside. We investigated the relationship between Interoceptive Accuracy (IAcc) and external perception of the body and we tested if seeing the body from an external perspective can affect IAcc. Fifty-two healthy female subjects performed a standard heartbeat perception task to assess the IAcc, before and after the Body Image Revealer (BIR), which is a body perception task designed to assess the different aspects of body-image. Read More

    Validation of the French Version of the DSM-5 Yale Food Addiction Scale in a Nonclinical Sample.
    Can J Psychiatry 2017 Mar 8;62(3):199-210. Epub 2016 Oct 8.
    1 CHRU de Tours, Équipe de Liaison et de Soins en Addictologie, Tours, France.
    Objective: The Yale Food Addiction Scale (YFAS) is the only questionnaire that assesses food addiction (FA) based on substance dependence criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM), Fourth Edition, Text Revision. Following recent updating of addiction criteria, a new DSM-5 version (YFAS 2.0) has been developed. Read More

    Oxyresveratrol Supplementation to C57bl/6 Mice Fed with a High-Fat Diet Ameliorates Obesity-Associated Symptoms.
    Nutrients 2017 Feb 16;9(2). Epub 2017 Feb 16.
    School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
    Oxyresveratrol has been proven effective in inhibiting adipogenesis in a 3T3-L1 cell model. We investigated the preventive effect of oxyresveratrol supplementation on obesity development in high-fat diet-fed mice. Male C57bl/6 mice were randomly subjected to control (5% fat by weight, LF), high-fat (30% fat by weight, HF), and high-fat supplemented with 0. Read More

    Metabolic Effects of Berries with Structurally Diverse Anthocyanins.
    Int J Mol Sci 2017 Feb 15;18(2). Epub 2017 Feb 15.
    Plants for Human Health Institute, North Carolina State University, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC 28081, USA.
    Overconsumption of energy dense foods and sedentary lifestyle are considered as major causes of obesity-associated insulin resistance and abnormal glucose metabolism. Results from both cohort studies and randomized trials suggested that anthocyanins from berries may lower metabolic risks, however these reports are equivocal. The present study was designed to examine effects of six berries with structurally diverse anthocyanin profiles (normalized to 400 µg/g total anthocyanin content) on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity. Read More

    Associations of Overweight, Obesity and Related Factors with Sleep-Related Breathing Disorders and Snoring in Adolescents: A Cross-Sectional Survey.
    Int J Environ Res Public Health 2017 Feb 15;14(2). Epub 2017 Feb 15.
    Pulmonary Division & Sleep Center, The First Hospital of Jilin University, Changchun 130021, China.
    Background: Sleep-related breathing disorders (SRBD) have been identified as a major public health problem closely related to adolescent obesity. We aimed to estimate the prevalences of SRBD and snoring in adolescents in Changchun City, Northeastern China, and to evaluate the associated factors in this population. Methods: In total, 1955 adolescents aged 11-18 years were recruited in Changchun City using stratified cluster sampling. Read More

    The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH.
    Mar Drugs 2017 Feb 15;15(2). Epub 2017 Feb 15.
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
    Edible seaweeds have been consumed by Asian coastal communities since ancient times. Fucus vesiculosus and Ascophyllum nodosum extracts have been traditionally used for the treatment of obesity and several gastrointestinal diseases. We evaluated the ability of extracts obtained from these algae to inhibit the digestive enzymes α-amylase and α-glucosidase in vitro, and control postprandial plasma glucose levels in a mouse model of non-alcoholic steatohepatitis (NASH); a liver disease often preceding the development of Type 2 diabetes (T2DM). Read More

    The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus.
    Nutrients 2017 Feb 15;9(2). Epub 2017 Feb 15.
    Liggins Institute, University of Auckland, Auckland 1021, New Zealand.
    Gestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. Read More

    Preventive Effects of Pentoxifylline on the Development of Colonic Premalignant Lesions in Obese and Diabetic Mice.
    Int J Mol Sci 2017 Feb 15;18(2). Epub 2017 Feb 15.
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
    Obesity and its related metabolic abnormalities, including enhanced oxidative stress and chronic inflammation, are closely related to colorectal tumorigenesis. Pentoxifylline (PTX), a methylxanthine derivative, has been reported to suppress the production of tumor necrosis factor (TNF)-α and possess anti-inflammatory properties. The present study investigated the effects of PTX on the development of carcinogen-induced colorectal premalignant lesions in obese and diabetic mice. Read More

    The association between pre-pregnancy obesity and screening results of depression for all trimesters of pregnancy, postpartum and 1 year after birth: a cohort study.
    J Perinat Med 2017 Feb 17. Epub 2017 Feb 17.
    Objective: To determine the relationship between pre-pregnancy obesity and screening results of gestational and post-delivery depression in women referred to the health centers of Tabriz, Iran.

    Methods: In this cohort study, 62 and 245 pregnant women with class 2-3 obesity [body mass index (BMI)≥35 kg/m2] and normal-weight (BMI 18.5-24. Read More

    Thirty-day outcomes for children and adolescents undergoing laparoscopic sleeve gastrectomy at a free-standing children's hospital.
    Clin Obes 2017 Feb 17. Epub 2017 Feb 17.
    Division of Pediatric Surgery, Children's National Medical Center, Washington, DC, USA.
    The obesity epidemic continues to affect millions of children and adolescents. Non-surgical options do not result in significant or sustained weight loss; thus bariatric surgery has become increasingly utilized. Limited data exist regarding safety for paediatric bariatric surgery, especially outside of National Institutes of Health (NIH)-funded centres. Read More

    Atypical Angelman syndrome due to a mosaic imprinting defect: Case reports and review of the literature.
    Am J Med Genet A 2017 Mar;173(3):753-757
    Hunter Genetics, Newcastle, Australia.
    Angelman syndrome (AS) is characterized by severe intellectual disability, limited, or absent speech and a generally happy demeanor. The four known etiological mechanisms; deletions, uniparental disomy, imprinting defects, and UBE3A mutation all affect expression of the UBE3A gene at 15q11-q13. An atypical phenotype is seen in individuals who are mosaic for a chromosome 15q11-q13 imprinting defect on the maternal allele. Read More

    DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese patients.
    Sci Rep 2017 Feb 17;7:41903. Epub 2017 Feb 17.
    CIBER Fisiopatología de la Obesidad y Nutricion (CIBERobn), Madrid, Spain.
    The characterization of the epigenetic changes within the obesity-related adipose tissue will provide new insights to understand this metabolic disorder, but adipose tissue is not easy to sample in population-based studies. We aimed to evaluate the capacity of circulating leukocytes to reflect the adipose tissue-specific DNA methylation status of obesity susceptibility. DNA samples isolated from subcutaneous adipose tissue and circulating leukocytes were hybridized in the Infinium HumanMethylation 450 BeadChip. Read More

    Insufficient sleep in adolescents: causes and consequences.
    Minerva Pediatr 2017 Feb 17. Epub 2017 Feb 17.
    Sleep Medicine, Department of Pulmonary and Sleep Medicine, Children's National Medical Center, Washington, MD, USA.
    Insufficient sleep poses an important and complicated set of health risks in the adolescent population. Not only is deficient sleep (defined as both sleep duration inadequate to meet sleep needs and sleep timing misaligned with the body's circadian rhythms) at epidemic levels in this population, but the contributing factors are both complex and numerous and there are a myriad of negative physical and mental health, safety and performance consequences. Causes of inadequate sleep identified in this population include internal biological processes such as the normal shift (delay) in circadian rhythm that occurs in association with puberty and a developmentally-based slowing of the "sleep drive", and external factors including extracurricular activities, excessive homework load, evening use of electronic media, caffeine intake and early school start times. Read More

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