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Toxicol Lett 2022 Jun 22. Epub 2022 Jun 22.

School of Public Health, North China University of Science and Technology, Tangshan Hebei 063210, China; Laboratory Animal Center, North China University of Science and Technology, Tangshan Hebei 063210, China.

Obesity and lead exposure can independently cause neuroinflammation, which is associated with neurodegenerative diseases. Although Th17 cells play critical roles in inflammatory diseases of the central nervous system, few studies have evaluated their role in neuroinflammation in the background of obesity and lead exposure. In this study, the mechanism underlying inflammatory injury was evaluated in a mouse model of high fat diet-induced obesity following lead exposure. Read More

Am J Perinatol 2022 Jun 25. Epub 2022 Jun 25.

Department of Obstetrics and Gynecology and Reproductive Sciences, University of Maryland Medical Center, Baltimore, United States.

Objective To evaluate if supraumbilical midline vertical incision performed in patients with a hanging pannus (umbilicus at the level of the pubic bone) is a reasonable alternative to Pfannenstiel in patients with Body Mass Index (BMI) ≥ 50 kg/m2 undergoing cesarean delivery. Methods Retrospective cohort study in patients with BMI ≥50 kg/m2 undergoing cesarean delivery at a single center from 2016 to 2020. Study groups were Pfannenstiel VS supraumbilical vertical skin incision. Read More

Psychoneuroendocrinology 2022 Jun 17;143:105842. Epub 2022 Jun 17.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Charité Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany. Electronic address:

Background: Nesfatin-1 has been described as an anorexigenic peptide. Comprehensive evidence also points towards an involvement of nesfatin-1 in the modulation of emotional pathways with a sex-specific regulation of nesfatin-1 in association with anxiety. Although the implication of nesfatin-1 in the regulation of food intake is well-established in animals, data in humans are lacking. Read More

Eur Eat Disord Rev 2022 Jun 25. Epub 2022 Jun 25.

CIRI - Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, Saint-Etienne, France.

Objective: Previous studies of AN showed low-grade inflammation. Are low-grade inflammation and circulating lymphocytes associated with chronic conditions?

Method: Peripheric blood cytokines were measured using Luminex™ technology in a chronic AN cohort (mean = 67.42 months), compared to Constitutional Thinness (CT), Constitutional Obesity (CO), and Healthy Controls (HC). Read More

Breast Cancer Res Treat 2022 Jun 25. Epub 2022 Jun 25.

Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, 10th Floor PCAM South, Philadelphia, PA, 19104, USA.

Purpose: To assess knowledge of obesity-associated cancer risk, self-awareness of BMI status, and willingness to engage in weight loss intervention in breast cancer survivors with overweight and obesity as a companion study for a novel weight loss program using a telehealth platform (NCT04855552).

Methods: Breast cancer survivors with BMI ≥ 25 kg/m were surveyed to assess self-perception of BMI, knowledge of obesity-related cancer risk, and willingness to participate in weight loss programs. Multivariable logistic regression was used to assess factors associated with willingness to participate. Read More

Int J Epidemiol 2022 Jun 25. Epub 2022 Jun 25.

Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.

Background: Due to its large impact on human health, socio-economic status (SES) could at least partially influence the established association between obesity and coronavirus disease 2019 (COVID-19) severity. To estimate the independent effect of body size and SES on the clinical manifestations of COVID-19, we conducted a Mendelian randomization (MR) study.

Methods: Applying two-sample MR approaches, we evaluated the effects of body mass index (BMI, n = 322 154), waist circumference (WC, n = 234 069), hip circumference (n = 213 019) and waist-hip ratio (n = 210 088) with respect to three COVID-19 outcomes: severe respiratory COVID-19 (cases = 8779, controls = 1 000 875), hospitalized COVID-19 (cases = 17 992, controls = 1 810 493) and COVID-19 infection (cases = 87 870, controls = 2 210 804). Read More

Mol Nutr Food Res 2022 Jun 25:e2200146. Epub 2022 Jun 25.

Institute of Food Sciences and Technology, National Taiwan University, Taipei, Taiwan.

Scope: Tight junctions (TJs) are a member of the intestinal epithelium barrier that provides the first line of protection against external factors. Anti-obesity and protective effects of pterostilbene (PSB) on TJs have previously been reported, but the effect of its colonic metabolite, pinostilbene (PIN), is less understood.

Methods And Results: A 16-week animal model fed with western-diet to induced colonic TJs disruption was designed, supplemented with PSB and PIN to evaluate their potent in colonic TJ protection. Read More

J Oral Rehabil 2022 Jun 25. Epub 2022 Jun 25.

Department of Pharmaceutical Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de São Paulo (UNIFESP), Brazil.

Background: Saliva is a non-invasive source of biomarkers useful in the study of different pathophysiological conditions. The qualitative and quantitative study of saliva, as well as the assessment of oral health, can be particularly useful for a better understanding of obesity due to its importance in the food oral perception and ingestion.

Objectives: To evaluate the effect of treatment of morbid obesity (dietary counselling versus gastroplasty) on salivary characteristics, oral sensory perception and dental health in a controlled study. Read More

Clin Transl Sci 2022 Jun 24. Epub 2022 Jun 24.

Amsterdam UMC, Vrije Universiteit, Department of Pharmacy and Clinical Pharmacology, Amsterdam, The Netherlands.

An accurate estimated glomerular filtration rate (eGFR) is essential in drug dosing. This study demonstrates the limitations of indexed (mL/min/1.73m ) and de-indexed (mL/min) eGFR based drug dosing in patients with obesity or underweight. Read More

Am J Case Rep 2022 Jun 25;23:e935584. Epub 2022 Jun 25.

Department of Internal Medicine, BronxCare Hospital, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.

BACKGROUND Necrotizing fasciitis is a life-threatening infection of the deep soft tissues that leads to progressive destruction of the fascia and subcutaneous fat. It typically spreads along the muscle fascia planes because of the relatively poor blood supply. Muscle tissue is usually spared because of its better blood supply. Read More

J Pak Med Assoc 2022 Jun;72(6):1237-1238

Department of Medicine, Belgaum Diabetes Centre & Childrens Diabetes Centre; Weight Watch Centre; MM Dental College, Belgaum; USM-KLE International Medical program, Belgaum, India.

This communication describes the style and content of obesity-friendly language, so as to create a positive and welcoming environment for the obese individual accessing health care. Attention to matters of language and conversation style will ensure better a relationship between the patient and provider and facilitate optimal outcomes. Read More

Pediatr Obes 2022 Jun 24:e12956. Epub 2022 Jun 24.

Department of Sustainable Health Science, Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.

Background: The association between maternal antibiotic exposure during pregnancy and childhood obesity is still unclear.

Objectives: The study aimed to evaluate the association between prenatal exposure to antibiotics and obesity at age 3 years using data from a large Japanese birth cohort.

Methods: The Japan Environment and Children's Study is a nationwide birth cohort study. Read More

Pediatr Obes 2022 Jun 24:e12951. Epub 2022 Jun 24.

Department of Child & Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Background: Children with Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) have an increased obesity risk. Although these conditions commonly co-occur, shared factors relating to obesity risk are unknown.

Objectives: To examine the shared and unique associations of ADHD and autistic traits with eating behaviours and BMI. Read More

BMC Public Health 2022 Jun 24;22(1):1251. Epub 2022 Jun 24.

School of Food Science and Nutrition, Faculty of Environment, University of Leeds, Leeds, LS2 9JT, UK.

Background: Previous evidence suggests that school garden-based programmes (SGBP) may be a promising yet cost-effective intervention to improve children's knowledge, attitudes and practices (KAP) on healthy eating. This review aimed to summarise and evaluate the evidence available on the impacts of SGBP in addressing diet and nutrition-related KAP among school-aged children.

Methods: Five databases including PubMed, Embase, Cochrane, Web of Science and Scopus were searched until February 2021. Read More

BMC Public Health 2022 Jun 24;22(1):1249. Epub 2022 Jun 24.

Department of Industrial Design National, Yunlin University of Science and Technology, No.123, Sec. 3, University Rd, Douliou, Yunlin City, 64002, Taiwan.

Background: Overweight and obesity have been described as a global epidemic that seriously affects the health of adults and children. Front of Package (FOP) Nutrition Labeling can increase consumers' awareness of unhealthy foods. The purpose of this study is to find effective deterrence and improve children's health awareness via the FOP. Read More

World J Pediatr 2022 Jun 25. Epub 2022 Jun 25.

Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 45 Nanlishi Road, Beijing 100045, China.

Background: Few studies have evaluated the specific age period in childhood when the association of body mass index with adult hyperuricemia begins to be operative. This study aimed to examine the associations between body mass index in different childhood age periods and the risk of adult hyperuricemia in China.

Methods: The study cohort from the China Health and Nutrition Survey included 676 participants who were aged ≥ 18 years and had data on uric acid in 2009 with at least one measurement of body mass index in childhood surveys before 2009. Read More

Cardiovasc Drugs Ther 2022 Jun 24. Epub 2022 Jun 24.

Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325035, Wenzhou, China.

Purpose: Schisandra is a well-known traditional Chinese medicine in East Asia. As a traditional Chinese medicine derivative with Schisandra chinensis as raw material, bicyclol is well known for its significant anti-inflammatory effect. Chronic inflammation plays a significant part in obesity-induced cardiomyopathy. Read More

Sleep Breath 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, Wisconsin Sleep, Wisconsin Institute for Sleep and Consciousness, School of Medicine and Public Health, University of Wisconsin-Madison, 1685 Highland Ave, Madison, WI, 53705, USA.

Purpose: To evaluate whether or not continuous positive airway pressure (CPAP) treatment in pregnancies complicated by obstructive sleep apnea (OSA) is associated with a decrease in hypertensive disorders of pregnancy.

Methods: This was a retrospective cohort study of perinatal outcomes in women who underwent objective OSA testing and treatment as part of routine clinical care during pregnancy. Where diagnostic criteria for OSA were reached (respiratory event index (REI) ≥ 5 events per hour), patients were offered CPAP therapy. Read More

Nat Commun 2022 Jun 24;13(1):3613. Epub 2022 Jun 24.

Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.

The success of glucagon-like peptide-1 (GLP-1) receptor agonists to treat type 2 diabetes (T2D) and obesity has sparked considerable efforts to develop next-generation co-agonists that are more effective. We conducted a randomised, placebo-controlled phase 1b study (ClinicalTrials.gov: NCT04466904) to evaluate the safety and efficacy of IBI362 (LY3305677), a GLP-1 and glucagon receptor dual agonist, in Chinese patients with T2D. Read More

Clin Lymphoma Myeloma Leuk 2022 May 29. Epub 2022 May 29.

Sarah Cannon - Nashville TN.

It has been proposed that direct measurement of adiposity has a greater accuracy as a prognostic factor in various malignancies than anthropometric measures such as BMI. We evaluated the association of visceral and subcutaneous adiposity with outcomes in patients with hematological malignancies with a systematic review and meta-analysis. This systematic review included patients with hematological malignancies who had the analysis of overall mortality and progression-free survival according to their adiposity status. Read More

Surg Obes Relat Dis 2022 May 18. Epub 2022 May 18.

Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: Obesity has become a global problem that poses a serious threat to human health. Laparoscopic sleeve gastrectomy (LSG) is an effective long-term treatment. However, the weight loss of some patients after LSG is still insufficient. Read More

Air Med J 2022 Jul-Aug;41(4):396-401. Epub 2022 Jan 10.

Department of Anesthesia, Chilean Air Force Hospital, Santiago, Chile.

Objective: Critical care air transport has played an important role during the coronavirus disease 2019 (COVID-19) pandemic. The goal of this article is to analyze results and lessons learned from the evacuation of the first 100 COVID-19 patients transported between medical facilities in Chile.

Methods: We reviewed prospective data of patients who were referred for air transport between March 27, 2020, and July 9, 2020. Read More

Lancet Digit Health 2022 Jul;4(7):e480-e481

Department of Medicine - Division of Endocrinology-Neuroendocrine, Department of Pediatrics - Division of Endocrinology, Nutrition Obesity Research Center at Harvard, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

J Vasc Nurs 2022 Jun 23;40(2):112-116. Epub 2022 May 23.

Faculdade de Medicina, Universidade Federal de Uberlândia, Campus Umuarama - Bloco 2U, Brazil. Electronic address:

Objective: To identify the relationship between the Ankle Brachial Index (ABI) and the presence of cardio-metabolic diseases, alcohol, and tobacco abuse among truck drivers.

Methods: This is a cross-sectional study with a quantitative approach carried out with 235 truck drivers. Demographic, professional, clinical, alcohol, and tobacco abuse data were collected through interviews. Read More

Prev Med 2022 Jun 21:107120. Epub 2022 Jun 21.

Department of Educational Foundations, Organizations, and Policy, University of Pittsburgh, PA, USA.

Although the positive relationship between arts engagement and mental health is well documented, arts participation may be an emergent factor in the ecology of childhood obesity. Prior research hypothesized several potential health benefits of arts participation including healthy diet and lifestyles, but the available evidence is mainly limited to cross-sectional covariate-adjustment models for the adult population. We employed a newly released panel of the Early Childhood Longitudinal Study kindergarten cohort (ECLS-K: 2011), which is a nationally representative sample of American children who entered kindergarten in 2010-2011 (n = 15,820). Read More

Physiol Behav 2022 Jun 21:113890. Epub 2022 Jun 21.

Mt Sinai St. Luke's Hospital, Icahn School of Medicine at Mt Sinai, 1 Gustave L. Levy Pl, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mt Sinai, 1 Gustave L. Levy Pl, New York, NY 10029, USA; Department of Psychology, Touro College and University System, 320 W 31st St, New York, NY 10001, USA.

Background: . Lifestyle factors like time of eating and stress exposure may impact physiology to promote excess weight gain. To understand behavioral and physiological mechanisms underlying these potential effects, we compared appetite and gut hormone responses to a series of meal and stress challenges beginning in the morning and the afternoon, in adults with normal-weight and obesity. Read More

Ann Endocrinol (Paris) 2022 Jun 21. Epub 2022 Jun 21.

Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; Department of Diabetes and Endocrinology, Imperial College Healthcare NHS Trust, London, UK. Electronic address:

Reproduction and metabolism are intricately linked. Gut hormones play key roles in the regulation of body weight and glucose homeostasis, factors that influence the functioning of the hypothalamic-pituitary-gonadal axis and reproductive outcomes. Data from rodent models suggest gut hormones may have direct stimulatory effects on reproductive hormone release. Read More

Reprod Toxicol 2022 Jun 21. Epub 2022 Jun 21.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Maternal obesity is associated with an increased risk of adverse pregnancy outcomes including stillbirth, and their etiology is thought to be related to placental and fetal hypoxia. In this study, we sought to investigate the levels of lactate in maternal and umbilical cord blood, a well characterized biomarker for hypoxia, and expression of plasma membrane lactate transporter MCT1 and MCT4 in the placental syncytiotrophoblast (STB), which are responsible for lactate uptake and extrusion, respectively, from pregnant women with a diagnosis of obesity following a Cesarean delivery at term. With use of approaches including immunofluorescence staining, Western blot, RT-qPCR and ELISA, our results revealed that in controls the expression of MCT1 was equally observed between basal (fetal-facing, BM) and microvillous (maternal-facing, MVM) membrane of the STB, whereas MCT4 was predominantly expressed in the MVM but barely detected in the BM. Read More

Cell Metab 2022 Jun 18. Epub 2022 Jun 18.

Clinic of Endocrinology, Diabetes and Metabolism University Hospital Basel, Basel, Switzerland; Department of Biomedicine, University of Basel, Basel, Switzerland.

The initial cephalic phase of insulin secretion is mediated through the vagus nerve and is not due to glycemic stimulation of pancreatic β cells. Recently, IL-1β was shown to stimulate postprandial insulin secretion. Here, we describe that this incretin-like effect of IL-1β involves neuronal transmission. Read More

Food Chem 2022 Jun 16;394:133500. Epub 2022 Jun 16.

College of Food Science, Southwest University, Beibei, Chongqing 400715, China; Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Southwest University, Beibei, Chongqing 400715, China. Electronic address:

Obesity is one of the circadian rhythm disorders (CRD)-mediated metabolic disorder syndromes. Pu-erh tea is a viable dietary intervention for CRD, however its effect on CRD-induced obesity is unclear. Here, we found that Pu-erh tea improved obesity in CRD-induced mice, which stemmed from the production of Cinnabarinic acid (CA). Read More