286,268 results match your criteria Obesity

Protective Effects of an Obesity-Associated Polymorphism (CDKAL1 rs9356744) on Prediabetes: The Cardiometabolic Risk in Chinese (CRC) Study.

Exp Clin Endocrinol Diabetes 2018 Jun 22. Epub 2018 Jun 22.

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States.

Background: Obesity is strongly associated with insulin resistance and elevated plasma glucose levels. The rs9356744 polymorphism in the gene is associated with body mass index (BMI) only in East Asians. Here, we examined the effect of the rs9356744 polymorphism on glucose-related traits and prediabetes in Chinese adults. Read More

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Understanding the health and wellbeing challenges of the food banking system: A qualitative study of food bank users, providers and referrers in London.

Soc Sci Med 2018 May 16;211:95-101. Epub 2018 May 16.

Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, United Kingdom.

In the UK, food poverty has been associated with conditions such as obesity, malnutrition, hypertension, iron deficiency, and impaired liver function. Food banks, the primary response to food poverty on the ground, typically rely on community referral and distribution systems that involve health and social care professionals and local authority public health teams. The perspectives of these key stakeholders remain underexplored. Read More

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Association of polybrominated diphenyl ethers in two fat compartments with increased risk of insulin resistance in obese individuals.

Chemosphere 2018 Jun 18;209:268-276. Epub 2018 Jun 18.

Anti Doping Laboratory Qatar, Sports City, Doha, Qatar; Division of Medicine, University College London, London, UK. Electronic address:

Background: Polybrominated diphenyl ethers (PBDEs), a widely utilized class of flame retardants in various commercial products, represent a prominent source of environmental contaminants. PBDEs tend to accumulate in adipose tissue, potentially altering the function of this endocrine organ and increasing risk of insulin resistance. The aim of this study was to compare levels of PBDEs in adipose tissues from two metabolically distinct obese groups; the insulin sensitive (IS) and the insulin resistant (IR). Read More

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Beyond the tip of the iceberg: Adolescent weight development of women and men with features of binge eating disorder.

Eat Behav 2018 Jun 14;30:83-87. Epub 2018 Jun 14.

Department of Public Health, University of Helsinki, Finland.

Objective: Binge eating disorder (BED) is a clinical eating disorder that is strongly and bidirectionally related to overweight and obesity. Little is known about how subclinical features of BED relate to weight development in adolescence and young adulthood.

Method: Women (n = 2825) and men (n = 2423) from the community-based longitudinal FinnTwin16 cohort participated. Read More

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Bariatric patients' nutritional status as a risk factor for postoperative complications, prolonged length of hospital stay and hospital readmission: a retrospective cohort study.

Int J Surg 2018 Jun 19. Epub 2018 Jun 19.

2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland; Department of Endoscopic, Metabolic and Soft Tissue Tumors Surgery, Krakow, Poland; Centre for Research, Training and Innovation in Surgery (CERTAIN Surgery), Krakow, Poland. Electronic address:

Background: The prevalence of obesity is growing worldwide. Malnutrition has been identified as a risk factor, leading to higher morbidity rate and prolonged length of hospital. So far there are no high quality data on the impact of malnutrition on length of hospital stay and morbidity regarding bariatric surgery. Read More

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Metabolic Pathway Engineering for High-level Production of 5-Hydroxytryptophan in Escherichia coli.

Metab Eng 2018 Jun 19. Epub 2018 Jun 19.

Key Laboratory of Biomass Chemical Engineering (Education Ministry), College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; Institute of Biological Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; Shandong Institute for Food and Drug Control, Jinan 250101, China. Electronic address:

Cellular metabolic networks should be carefully balanced using metabolic engineering to produce the desired products at the industrial scale. As the precursor for the biosynthesis of the neurotransmitter serotonin, 5-hydroxytryptophan (5-HTP) is effective in treating a variety of diseases, such as depression, fibromyalgia, obesity, and cerebellar ataxia. Due to the lack of an efficient synthetic method, commercial production of 5-HTP is only achieved by extracting from the seeds of Griffonia Smplicifolia. Read More

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Progress and challenges of selective Farnesoid X receptor modulation.

Pharmacol Ther 2018 Jun 19. Epub 2018 Jun 19.

Center for Molecular Medicine, UMC Utrecht, Utrecht University, Utrecht, the Netherlands; Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

Bile acids are amphipathic molecules that were previously known to serve as fat solubilizers in the intestine in postprandial conditions. In the last two decades, bile acids have been recognized as signaling molecules regulating energy metabolism pathways via, amongst others, the farnesoid X receptor (FXR). Upon bile acid activation, FXR controls expression of genes involved in bile acid, lipid, glucose and amino acid metabolism. Read More

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DNA methylation of SSPN is linked to adipose tissue distribution and glucose metabolism.

FASEB J 2018 Jun 22:fj201800528R. Epub 2018 Jun 22.

Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany.

DNA methylation is a crucial epigenetic mechanism in obesity and fat distribution. We explored the Sarcospan ( SSPN) gene locus by using genome-wide data sets comprising methylation and expression data, pyrosequencing analysis in the promoter region, and genetic analysis of an SNP variant rs718314, which was previously reported to associate with waist-to-hip ratio. We found that DNA methylation influences several clinical variables related to fat distribution and glucose metabolism, while SSPN mRNA levels showed directionally opposite effects on these traits. Read More

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Health Coaching Strategy to Improve Glycemic Control in African- American Adults with Type 2 Diabetes: An Integrative Review.

Larider Ruffin

J Natl Black Nurses Assoc 2017 Jul;28(1):54-59

Diabetes is a complex, chronic illness requiring continuous medical care with multifactorial risk-reduction strategies for appropriate glycemic control. Type 2 diabetes remains a global epidemic secondary to increases in physical inactivity and obesity. While many populations are at risk, African-Americans bear a disproportionate burden from diabetes and its complications. Read More

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Views of Obesity in Black Women from a Cultural Perspective.

J Natl Black Nurses Assoc 2017 Jul;28(1):50-53

This article conveys the authors' perspectives and insights gained during the development and implementation of their experience with a community-based intervention designed to address obesity among Black women. The reader gets a look at the authors' personal weight struggles, as the intervention they designed to help others transformed their lives as well as the participants. The authors also shared their perspectives on the impact of religion and spirituality on healthy lifestyles. Read More

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The World Health Organization - Community Empowerment Model in Addressing Food Insecurity in Low-Income African-American Women: A Review of the Literature.

J Natl Black Nurses Assoc 2017 Jul;28(1):43-49

Numerous researchers have examined the serious consequences of food insecurity and food deserts affecting the nutritional health of poor or low-income African-American women and their families. Food insecurity is defined as having limited or uncertain capacityfor acquiring sufficient, safe, and nutritious food at all times to meet one's dietary needs, while food deserts refer to economically and socially-deprived inner city areas with inadequate food supply that are often inhabited by low-income groups. Researchers have found that despite the capacity of community-level resources such as SNAP (Supplemental Nutrition Assistance Program) and WIC (Women, Infants, and Children) supporting healthy nutrition, food insecurity persists among some recipients of both nutritional resources. Read More

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The Community Compass Project: A Community Engagement Model Targeting African-Americans in the Low Country of South Carolina.

J Natl Black Nurses Assoc 2017 Jul;28(1):38-42

Despite cutting edge progress in early detection, risk reduction, and prevention, unique contextual and sociocultural factors contribute to higher mortality rates for selected cancers in African-American men and women. Collaborative community engagement and outreach programming strategies that focus on sustainability and grass-roots organizing can inform health risk disparities, build trust, and allow communities to take ownership of their own health needs. This paper describes a successful evidence-based community engagement intervention woven into the social and interpersonal fabric of the African-American community in Charleston, South Carolina. Read More

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Does Love Really Make Mothers Blind? A Large Transcontinental Study on Mothers' Awareness About Their Children's Weight.

Obesity (Silver Spring) 2018 Jul;26(7):1211-1224

Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy.

Objective: The aim of this study was to assess maternal misperception rates (perception as normal or underweight of a child with overweight or obesity) and their role in affecting the chance of implementing actions to change children's weight.

Methods: Obesogeneicity of Gadgets Marketed with Snacks (OBEY-AD) is an international study investigating factors promoting childhood overweight and obesity in 10 countries, in which 2,720 child-mother dyads have been enrolled. Mothers' perception of their children's weight was assessed using a projective test. Read More

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Effect of Lower Versus Higher Protein Content in Infant Formula Through the First Year on Body Composition from 1 to 6 Years: Follow-Up of a Randomized Clinical Trial.

Obesity (Silver Spring) 2018 Jul;26(7):1203-1210

Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.

Objective: The objective of this study was to investigate the effect of lower protein (LP) versus higher protein (HP) content in infant formula on body composition from 3 months to 6 years.

Methods: In a multicenter, double-blind European trial, healthy infants (N = 1,090) were randomly assigned to different protein content formulas (upper [HP] and lower [LP] limits of the European Union regulations in 2001) during the first year; breastfed infants (N = 588) were recruited for reference values. Weight, height, and triceps and subscapular skinfold (SF) thickness were measured repeatedly (N = 650 at 6 years), and body composition was estimated (Slaughter). Read More

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Normalization of Plus Size and the Danger of Unseen Overweight and Obesity in England.

Raya Muttarak

Obesity (Silver Spring) 2018 Jul;26(7):1125-1129

Wittgenstein Centre for Demography and Global Human Capital (IIASA, VID/ÖAW, and WU), International Institute for Applied Systems Analysis, Laxenburg, Austria.

Objective: This study aimed to investigate trends and sociodemographic factors underlying weight misperception in adults with overweight and obesity in England.

Methods: This study used descriptive and logistic regression analyses based on a pooled nationally representative cross-sectional survey, Health Survey for England, for the years 1997, 1998, 2002, 2014, and 2015 of individuals with BMI ≥ 25 (n = 23,459). The main outcomes were (1) weight misperception and (2) weight-loss attempts as well as the associations with demographic and socioeconomic characteristics and health status. Read More

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Combined Treatment for Obesity and Depression: A Pilot Study.

Obesity (Silver Spring) 2018 Jul;26(7):1144-1152

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Objective: Obesity and depression frequently co-occur, and each increases risk for cardiovascular disease (CVD). This study tested whether a combined treatment, targeting obesity and depression simultaneously, would yield greater improvements in weight, mood, and CVD risk factors than treatments that targeted each disease individually.

Methods: Seventy-six participants with obesity and major depression were randomly assigned to (1) behavioral weight control (BWC), (2) cognitive behavioral therapy for depression (CBT-D), or (3) BWC combined with CBT-D. Read More

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Why Thinking We're Fat Won't Help Us Improve Our Health: Finding the Middle Ground.

Obesity (Silver Spring) 2018 Jul;26(7):1115-1116

Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.

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Are Protein Levels in Infant Formula a Driving Factor for Childhood Obesity Development?

Holly R Hull

Obesity (Silver Spring) 2018 Jul;26(7):1114

Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas.

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Physical activity protects NLRP3 inflammasome-associated coronary vascular dysfunction in obese mice.

Physiol Rep 2018 Jun;6(12):e13738

Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, Texas.

Activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome mediates the release of pro-inflammatory cytokine interleukin (IL)-1β and thereby plays a pivotal role in the inflammatory response in vascular pathology. An active lifestyle has beneficial effects on inflammation-associated vascular dysfunction in obesity. However, it remains unclear how physical activity regulates NLRP3 inflammasome-mediated vascular dysfunction in obesity. Read More

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June 2018
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Nonlinear mixed models of growth curves from domestic shorthair cats in a breeding colony, housed in a seasonal facility to predict obesity.

J Anim Physiol Anim Nutr (Berl) 2018 Jun 22. Epub 2018 Jun 22.

School of Agriculture and Environment, Massey University, Palmerston North, New Zealand.

Obesity is highly prevalent in pet cats (Felis silvestris catus) and is associated with several comorbidities, yet very little is understood about the early life risk factors. The aim of this study was to develop a mathematical model that describes growth in cats, to determine which early life variables were associated with being overweight in adulthood and to identify when during life the overweight phenotype developed in a colony of cats. We used pedigree, birth and growth data of 212 colony cats that were fed ad libitum from weaning. Read More

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Serum Levels of Angiopoietin-Like Protein 2 and Obestatin in Iranian Women with Polycystic Ovary Syndrome and Normal Body Mass Index.

J Clin Med 2018 Jun 22;7(7). Epub 2018 Jun 22.

The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514947932, Iran.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproduction age and a major cause of anovulatory infertility. Insulin resistance plays an important role in the development and durability of this disorder. ANGPTL2 is known as an inflammatory mediator derived from adipose tissue that links obesity to systemic insulin resistance, and obestatin has been identified as a hormone associated with insulin resistance that suppresses food reabsorption, inhibits gastric emptying and decreases weight gain. Read More

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Obesity, independent of diet, drives lasting effects on intestinal epithelial stem cell proliferation in mice.

Exp Biol Med (Maywood) 2018 Jun;243(10):826-835

1 Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

The intestinal epithelium plays an essential role in nutrient absorption, hormone release, and barrier function. Maintenance of the epithelium is driven by continuous cell renewal by intestinal epithelial stem cells located in the intestinal crypts. Obesity affects this process and results in changes in the size and function of the tissue. Read More

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Potential role of microRNAs in the regulation of adipocytes liposecretion and adipose tissue physiology.

J Cell Physiol 2018 Jun 22. Epub 2018 Jun 22.

Dipartimento di Sanità Pubblica, Medicina Sperimentale e Forense, Unità di Scienza dell'Alimentazione, Università degli studi di Pavia, Pavia, Italy.

Adipose tissue is a dynamic endocrine organ playing a pivotal role in metabolism modulation. Adipocytes differentiation requires a highly orchestrated series of changes of gene expression in precursor cells. At the same time, white mature adipocytes are plastic cells able to reversibly transdifferentiate toward fibroblast-like cells via the liposecretion process, returning back to a non-committed status of the cells. Read More

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Effects of Fish Oil on Lipid Metabolism and Its Molecular Biological Regulators in Chronic Ethanol-Fed Rats.

Nutrients 2018 Jun 22;10(7). Epub 2018 Jun 22.

School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan.

The purpose of this study was to clarify the hepatoprotective mechanisms of fish oil in ethanol-fed rats based on lipid metabolism. Thirty eight-week-old male Wistar rats were divided into six groups: C (control), CF25 (control diet with 25% fish oil substitution), CF57 (control diet with 57% fish oil substitution), E (ethanol-containing diet) group, EF25 (ethanol-containing diet with 25% fish oil substitution), and EF57 (ethanol-containing diet with 57% fish oil substitution) groups. All of the groups were pair-fed an isoenergetic diet based on E group. Read More

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Relationship of weight and obesity with the risk of knee and hip arthroplasty for osteoarthritis across different levels of physical performance: a prospective cohort study.

Scand J Rheumatol 2018 Jun 22:1-8. Epub 2018 Jun 22.

a Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine , Monash University , Melbourne , Australia.

Objective: To examine the association between obesity and knee and hip arthroplasty for osteoarthritis across a range of physical performance.

Method: The body mass index and physical performance (on the 36-item Short Form Health Survey) of 9135 Australian Diabetes, Obesity and Lifestyle Study participants were measured in 1999-2000. The incidence of knee and hip arthroplasty during 2002-2011 was determined by linking the cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. Read More

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Relationships of Obesity-Related Behavior Patterns With Socioeconomic Status and Acculturation in Korean American Women.

Clin Nurs Res 2018 Jun 1:1054773818783467. Epub 2018 Jun 1.

2 Yale University, Orange, CT, USA.

There is limited understanding about the obesity-related behaviors of diet, physical activity, and sedentary behavior in Korean American women. The purpose of this study was to cluster obesity-related behavior patterns of Korean American women and to examine group differences in acculturation, socioeconomic status (SES), and body mass index (BMI). A secondary analysis from a cross-sectional study was conducted using two-step cluster analysis for clustering groups. Read More

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Supplementation of Lactobacillus plantarum improves markers of metabolic dysfunction induced by a high fat diet.

J Proteome Res 2018 Jun 22. Epub 2018 Jun 22.

Obesity is a prevalent chronic condition in many developed and developing nations that raises the risk for developing heart disease, stroke, and diabetes. Previous studies have shown that consuming particular probiotic strains of Lactobacillus is associated with improvement in the obese and diabetic phenotype; however, the mechanisms of these beneficial effects are not well understood. In this study, C57BL/6J male mice were fed a lard-based high fat diet for 15 weeks with Lactobacillus plantarum supplementation NCIMB8826 (Lp) between weeks 10 and 15 (n=10 per group). Read More

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[Immediate-early c-fos and tyrosine hydroxylase protein expression in different brain regions in high-fat induced obesity in mice].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2017 Jun;33(6):572-576

Basic Medical School of Inner Mongolia Medical University, Huhehaote 010110, China.

Objective: To examine brain dopamine expression in chronic high-fat diet(HFD)-induced obese mice.

Methods: Ten male mice were fed by a high-fat diet (HF:45% of calories from fat) for 12 weeks and then classified as HFD group. Ten male mice were fed a low-fat diet (LF:10% of calories from fat) and used as control group (NCD). Read More

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Obesity and diabetes - not only a simple link between two epidemics.

Diabetes Metab Res Rev 2018 Jun 21:e3042. Epub 2018 Jun 21.

Department of Children's Diabetology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Diabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization (WHO). Obesity is not only involved in the etiopathogenesis of the most common worldwide type of DM - type 2 diabetes (T2D), but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes (T1D). Read More

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Postprandial Triglycerides Predict Newborn Fat More Strongly than Glucose in Women with Obesity in Early Pregnancy.

Obesity (Silver Spring) 2018 Jun 22. Epub 2018 Jun 22.

Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Objective: Maternal obesity (OB) accounts for the majority of large-for-gestational-age infants, and newborn percent fat (NB%fat) correlates strongest with childhood OB. In addition to maternal glucose, fasting triglycerides (TGs) may contribute, but postprandial triglycerides (PPTGs) are unstudied. It was hypothesized that fasting TGs and PPTGs are higher in women with OB compared with women with normal weight (NW) throughout pregnancy, correlate more strongly with NB%fat than glucose, and may relate to dietary chylomicron TGs. Read More

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Impact of motivational interviewing on outcomes of an adolescent obesity treatment: results from the MI Values randomized controlled pilot trial.

Clin Obes 2018 Jun 21. Epub 2018 Jun 21.

Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia, USA.

The aim of this study is to examine outcomes from MI Values, a motivational interviewing (MI) intervention implemented adjunctive to obesity treatment. Adolescents (n = 99; 73% African American; 74% female; mean body mass index [BMI] percentile = 98.9 ± 1. Read More

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Emotional eating is learned not inherited in children, regardless of obesity risk.

Pediatr Obes 2018 Jun 21. Epub 2018 Jun 21.

Department of Behavioural Science and Health, University College London, London, UK.

Background: Emotional over-eating (EOE) and emotional under-eating (EUE) are common behaviours that develop in early childhood and are hypothesised to play a role in weight status. Data from a British twin cohort demonstrated that environmental, rather than genetic, factors shape individual differences in both behaviours in early childhood.

Objective: The aim of this current study was to replicate this finding in a subsample (n = 398) of 4-year-old twins selected for high or low risk of obesity from another population-based cohort of British twins (the Twins Early Development Study). Read More

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Evaluation of Nutrition Imbalance in Chinese Chronic Kidney Disease Children.

Pediatr Int 2018 Jun 22. Epub 2018 Jun 22.

Department of Nephrology, Beijing Key Laboratory of Chronic Kidney Disease and Blood Purification of Children, Beijing Children's Hospital, Capital Medical University, South Lishi Road, Xicheng District, Beijing, China.

Background: Nutrition imbalance is common in chronic kidney disease (CKD) children. This study was to evaluate nutrition status of CKD children at different stages using bioimpedance analysis (BIA) compared with anthropometric measurements.

Methods: Fifty-five CKD children at III, IV, V stages and 19 age and sex-matched healthy controls were recruited. Read More

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Effect of android fat distribution on thrombin-activatable fibrinolysis inhibitor levels in women with polycystic ovary syndrome.

Int J Gynaecol Obstet 2018 Jun 21. Epub 2018 Jun 21.

Department of Gynecology and Obstetrics, School of Medical Sciences University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Women with polycystic ovary syndrome (PCOS) often present with thromboembolic risk factors, such as obesity, hyperandrogenism, and insulin resistance [1]. Furthermore, some PCOS-related metabolic abnormalities represent cardiovascular risk factors. We aimed to assess the association between hemostatic parameters and clinical and dual-energy X-ray absorptiometry (DXA) measurements of fat distribution in these women. Read More

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Predictors of coronary stent thrombosis: a case-control study.

J Thromb Thrombolysis 2018 Jun 21. Epub 2018 Jun 21.

Faculdade de Ciências Médicas da Universidade de Pernambuco (FCM/UPE), Recife, Brazil.

To verify the frequency and predictors associated with stent thrombosis (ST) in a developing country. Observational, case-control study including 2535 consecutive patients undergoing percutaneous coronary intervention (PCI) in two reference hospitals in Brazil, from October 2013 to December 2015. ST patients were matched to controls in a 1:3 ratio for gender, age, procedure indication, and performing hospital. Read More

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The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes.

Curr Diab Rep 2018 Jun 21;18(8):55. Epub 2018 Jun 21.

Department of Internal Medicine, MC Slotervaart, Amsterdam, The Netherlands.

Purpose Of Review: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D).

Recent Findings: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developing obesity and T2D. The introduction of high-throughput sequencing technologies has provided novel insight into the interpersonal differences in microbiome composition and function. Read More

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There is a Close Association Between the Recovery of Liver Injury and Glycemic Control after SGLT2 Inhibitor Treatment in Japanese Subjects with Type 2 Diabetes: A Retrospective Clinical Study.

Diabetes Ther 2018 Jun 21. Epub 2018 Jun 21.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Kurashiki, Japan.

Introduction: Sodium-glucose co-transporter 2 (SGLT2) inhibitors function not only to reduce hyperglycemia but also to ameliorate liver injury and reduce body weight. The aim of this study was to examine in which subjects SGLT2 inhibitors are more effective for glycemic control, liver injury, and obesity in Japanese subjects with type 2 diabetes mellitus.

Methods: We enrolled a total of 156 subjects with type 2 diabetes who initiated SGLT2 inhibitor treatment after September 1, 2014 in Kawasaki Medical School (Protocol No. Read More

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Discrepancies Between BMI and Classic Cardiovascular Risk Factors.

Obes Surg 2018 Jun 21. Epub 2018 Jun 21.

Department of Internal Medicine, Franciscus Gasthuis, PO Box 10900, 3004 BA, Rotterdam, The Netherlands.

Background: Obesity is related to increased cardiovascular risk. It is unknown whether increasing levels of obesity also increase levels of cardiovascular risk factors and systemic inflammation. This study describes the relationship between classic cardiovascular risk factors and inflammatory markers with BMI in a group of obese and non-obese subjects. Read More

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Thirteen-Year Experience of Laparoscopic Sleeve Gastrectomy: Surgical Risk, Weight Loss, and Revision Procedures.

Obes Surg 2018 Jun 21. Epub 2018 Jun 21.

Department of International Business, Chien Hsin University of Science and Technology, Tauoyan, Taiwan, Republic of China.

Background: Laparoscopic sleeve gastrectomy (LSG) has been validated as a safe and effective treatment for morbid obesity. However, data of the long-term outcome remains lacking.

Methods: A total of 1759 LSG was performed as primary bariatric procedure from 2005 to 2017 with mean age of 35. Read More

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Weight Loss Surgery Reduces Healthcare Resource Utilization and All-Cause Inpatient Mortality in Morbid Obesity: a Propensity-Matched Analysis.

Obes Surg 2018 Jun 21. Epub 2018 Jun 21.

Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, 2nd floor, Columbus, OH, USA.

Aims: There is a lack of population studies evaluating the impact of bariatric surgery (BRS) on all-cause inpatient mortality. We sought to determine the impact of prior BRS on all-cause mortality and healthcare utilization in hospitalized patients.

Methods: We analyzed the National Inpatient Sample database from 2007 to 2013. Read More

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The association between weight maintenance and session-by-session diet adherence, weight loss and weight-loss satisfaction.

Eat Weight Disord 2018 Jun 21. Epub 2018 Jun 21.

Department of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89, 37016, Garda, VR, Italy.

Objective: The aim of this study was to assess the association between weight-loss maintenance and weight-loss satisfaction, adherence to diet and weight loss, all measured session-by-session during the weight-loss phase of cognitive behavioral therapy.

Methods: The present exploratory study examined a subgroup of fifty-eight patients who participated in a randomized controlled trial and who lost at least the 10% of their baseline weight. Patients were grouped into weight-loss 'Maintainers' (i. Read More

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Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia.

Acta Diabetol 2018 Jun 22. Epub 2018 Jun 22.

Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.

Aims: Prior exposure to insulin-induced hypoglycemia was shown to increase glial acetate metabolism (GAM) during subsequent exposure to hypoglycemia in diabetic individuals. However, it remained unclear whether this effect was dependent on the disease state or the antecedent cause of hypoglycemia. We aimed to establish whether exposure to fasting-induced hypoglycemia was sufficient to produce alterations in GAM in non-diabetic individuals. Read More

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Ethnic differences in progression of islet autoimmunity and type 1 diabetes in relatives at risk.

Diabetologia 2018 Jun 21. Epub 2018 Jun 21.

Section of Diabetes and Endocrinology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, 6701 Fannin St, Suite 10.20, Houston, TX, 77030, USA.

Aims/hypothesis: We hypothesised that progression of islet autoimmunity and type 1 diabetes mellitus differs among races/ethnicities in at-risk individuals.

Methods: In this study, we analysed the data from the Type 1 Diabetes TrialNet Pathway to Prevention Study. We studied 4873 non-diabetic, autoantibody-positive relatives of individuals with type 1 diabetes followed prospectively (11% Hispanic, 80. Read More

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Advances in the Genetics of Youth-Onset Type 2 Diabetes.

Curr Diab Rep 2018 Jun 22;18(8):57. Epub 2018 Jun 22.

Departments of Medicine and Epidemiology and Public Health, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, 670 West Baltimore Street, Room 4040, Baltimore, MD, 21201, USA.

Purpose Of Review: To provide an update on knowledge the role of genetics in youth-onset type 2 diabetes (T2D).

Recent Findings: The prevalence in youth of T2D, once thought to be exclusively a disease of adults, has increased by over 35% since 2001. Youth with T2D tend to have higher rates of complications, more aggressive disease, with more rapid loss of beta-cell function and a less favorable response to treatment than adults. Read More

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[Evidence of the Mini-/One-anastomosis-gastric-Bypass for being a standard procedure in obesity and metabolic surgery].

Chirurg 2018 Jun 21. Epub 2018 Jun 21.

Klinik für Adipositas- und Metabolische Chirurgie, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach am Main, Deutschland.

Background: The Mini gastric bypass/One anastomosis gastric bypass (MGB/OAGB) was the third most commonly performed procedure in Germany, with 13.9% of all obesity and metabolic procedures in 2017 (StuDoQ|MBE).

Objective: This article reviews the currently published evidence for MGB/OAGB and the historical evidence on one anastomosis reconstruction. Read More

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BMI-independent effects of gestational diabetes on human placenta.

J Clin Endocrinol Metab 2018 Jun 20. Epub 2018 Jun 20.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the Eberhard Karls University Tübingen, Germany.

Purpose: Recently, alterations of maternal lipid metabolism were shown to associate with gestational diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for placenta and fetal metabolism are currently not understood.

Methods: Maternal and placental lipid profiles were characterized in GDM and normal glucose tolerant (NGT) women. Read More

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Commentary on: Nonsurgical Medical Penile Girth Augmentation: A Retrospective Study of Psychological and Psychosexual Outcomes.

David B Sarwer

Aesthet Surg J 2018 Jun 20. Epub 2018 Jun 20.

Associate Dean for Research, Professor of Social and Behavioral Sciences, and Director of the Center for Obesity Research and Education, College of Public Health, Temple University, Philadelphia, PA.

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Utilizing Standard Data Transactions and Public-Private Partnerships to Support Healthy Weight Within the Community.

EGEMS (Wash DC) 2017 Dec 6;5(1):21. Epub 2017 Dec 6.

Schools of Nursing, Medicine, and Public Health, University of Washington.

Context: Obesity is a significant health issue in the United States that both clinical and public health systems struggle to address. Electronic health record data could help support multi-sectoral interventions to address obesity. Standards have been identified and created to support the electronic exchange of weight-related data across many stakeholder groups. Read More

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December 2017

Comparative Evaluation of the Effects of Three Different Recruitment Maneuvers during Laparoscopic Bariatric Surgeries of Morbid Obese Patients on Cardiopulmonary Indices.

Adv Biomed Res 2018 29;7:89. Epub 2018 May 29.

Department of Surgery, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Laparoscopic bariatric surgeries in morbid obese patients may be associated with atelectasis, hypercapnia, and hypoxemia, intra and postoperatively. Several strategies are used for the prevention of these consequences. This study aimed to examine the effects of three different recruitment maneuvers comparatively during surgery and the influence of the maneuvers on some cardiopulmonary indices. Read More

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Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception.

Clin Epigenetics 2018 8;10:77. Epub 2018 Jun 8.

3Reproductive Sciences Laboratory, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Via Olgettina 58, 20132 Milan, Italy.

Background: An increased incidence of imprint-associated disorders has been reported in babies born from assisted reproductive technology (ART). However, previous studies supporting an association between ART and an altered DNA methylation status of the conceived babies have been often conducted on a limited number of methylation sites and without correction for critical potential confounders. Moreover, all the previous studies focused on the identification of methylation changes shared among subjects while an evaluation of stochastic differences has never been conducted. Read More

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