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    1 OF 5532

    Associations Between Marijuana Use and Cardiovascular Risk Factors and Outcomes: A Systematic Review.
    Ann Intern Med 2018 Jan 23. Epub 2018 Jan 23.
    From The Wright Center for Graduate Medical Education, Scranton, Pennsylvania; University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California; Memorial Sloan Kettering Cancer Center, New York, New York; and University of Michigan, Ann Arbor, Michigan.
    Background: Marijuana use is increasing in the United States, and its effect on cardiovascular health is unknown.

    Purpose: To review harms and benefits of marijuana use in relation to cardiovascular risk factors and clinical outcomes.

    Data Sources: PubMed, MEDLINE, EMBASE, PsycINFO, and the Cochrane Library between 1 January 1975 and 30 September 2017. Read More

    Early Childhood Stress and Child Age Predict Longitudinal Increases in Obesogenic Eating among Low-Income Children.
    Acad Pediatr 2018 Jan 18. Epub 2018 Jan 18.
    Center for Human Growth and Development, 300 N. Ingalls Street, 10 (th) floor, University of Michigan, Ann Arbor, MI, 48109; Department of Pediatrics and Communicable Diseases, 1500 E. Medical Center Drive, University of Michigan Medical School, Ann Arbor, MI, 48109; Department of Nutritional Sciences, 1415 Washington Heights, University of Michigan School of Public Health, Ann Arbor, MI, 48109.
    Objective: To identify whether psychosocial stress exposure during early childhood predicts subsequent increased eating in the absence of hunger (EAH), emotional overeating, food responsiveness, and enjoyment of food.

    Methods: This was an observational longitudinal study. Among 207 low-income children (54. Read More

    Systemic inflammation as a predictor of brain aging: Contributions of physical activity, metabolic risk, and genetic risk.
    Neuroimage 2018 Jan 18. Epub 2018 Jan 18.
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA 90292, USA. Electronic address:
    Inflammatory processes may contribute to risk for Alzheimer's disease (AD) and age-related brain degeneration. Metabolic and genetic risk factors, and physical activity may, in turn, influence these inflammatory processes. Some of these risk factors are modifiable, and interact with each other. Read More

    Contribution of Adipose Tissue to Development of Cancer.
    Compr Physiol 2017 Dec 12;8(1):237-282. Epub 2017 Dec 12.
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
    Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell-intrinsic anomalies. Due to the ubiquitous nature of adipose tissue, many types of solid tumors grow in proximate or direct contact with adipocytes and adipose-associated stromal and vascular components, such as fibroblasts and other connective tissue cells, stem and progenitor cells, endothelial cells, innate and adaptive immune cells, and extracellular signaling and matrix components. Excess adiposity in obesity both increases risk of cancer development and negatively influences prognosis in several cancer types, in part due to interaction with adipose tissue cell populations. Read More

    Role of Perivascular Adipose Tissue in Health and Disease.
    Compr Physiol 2017 Dec 12;8(1):23-59. Epub 2017 Dec 12.
    Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, Madrid, Spain.
    Perivascular adipose tissue (PVAT) is cushion of fat tissue surrounding blood vessels, which is phenotypically different from other adipose tissue depots. PVAT is composed of adipocytes and stromal vascular fraction, constituted by different populations of immune cells, endothelial cells, and adipose-derived stromal cells. It expresses and releases an important number of vasoactive factors with paracrine effects on vascular structure and function. Read More

    Triglyceride Metabolism in the Liver.
    Compr Physiol 2017 Dec 12;8(1):1-8. Epub 2017 Dec 12.
    Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, USA.
    Triglyceride molecules represent the major form of storage and transport of fatty acids within cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids accrue in liver by hepatocellular uptake from the plasma and by de novo biosynthesis. Read More

    Intermittent nocturnal hypoxia and metabolic risk in obese adolescents with obstructive sleep apnea.
    Sleep Breath 2018 Jan 22. Epub 2018 Jan 22.
    Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
    Purpose: There is conflicting data regarding the independent associations of obstructive sleep apnea (OSA) with metabolic risk in obese youth. Previous studies have not consistently addressed central adiposity, specifically elevated waist to height ratio (WHtR), which is associated with metabolic risk independent of body mass index.

    Objective: The objective of this study was to determine the independent effects of the obstructive apnea-hypopnea index (OAHI) and associated indices of nocturnal hypoxia on metabolic function in obese youth after adjusting for WHtR. Read More

    Glycine enhances expression of adiponectin and IL-10 in 3T3-L1 adipocytes without affecting adipogenesis and lipolysis.
    Amino Acids 2018 Jan 22. Epub 2018 Jan 22.
    State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, People's Republic of China.
    Glycine supplementation has been reported to enhance white-fat loss and improve sensitivity to insulin in animals with obesity or type 2 diabetes. However, the underlying mechanisms responsible for the beneficial effects of glycine remain largely unknown. The purpose of this study was to test the hypothesis that glycine regulates adipocyte differentiation, adipogenesis, and lipolysis, therefore, contributing to white-fat reduction. Read More

    Diabetes in pregnancy: a new decade of challenges ahead.
    Diabetologia 2018 Jan 22. Epub 2018 Jan 22.
    Department of Endocrinology, The Canberra Hospital, Garran, ACT, Australia.
    Every 10 years, the Diabetic Pregnancy Study Group, a study group of the EASD, conducts an audit meeting to review the achievements of the preceding decade and to set the directions for research and clinical practice improvements for the next decade. The most recent meeting focused on the following areas: improving pregnancy outcomes for women with pregestational type 1 diabetes and type 2 diabetes; the influence of obesity and gestational diabetes on pregnancy outcomes; the determinants and assessment of fetal growth and development; and public health issues, including consideration of transgenerational consequences and economic burden. The audit meeting also considered the likely impact of 'omics' on research within the field and the potential of these technologies to enable precision-medicine approaches to management. Read More

    Association of Exposure to Communities With Higher Ratios of Obesity with Increased Body Mass Index and Risk of Overweight and Obesity Among Parents and Children.
    JAMA Pediatr 2018 Jan 22. Epub 2018 Jan 22.
    RAND Corporation, Boston, Massachusetts.
    Importance: Little is known about whether the substantial clustering of obesity and overweight within social and geographic networks results from causal pathways, such as social contagion and shared environments, or from self-selection.

    Objectives: This study aimed to determine whether exposure to communities with higher rates of obesity increases the body mass index (BMI) of individuals, calculated as weight in kilograms divided by height in meters squared, and their risk of being overweight or obese, and whether social contagion, shared environments, or self-selection can account for identified differences.

    Design, Setting, And Participants: This natural experiment study used the routine assignment of military service members to installations as a source of exogenous variation in exposure to communities with higher vs lower rates of obesity. Read More

    Risk Factors for Prolonged Postoperative Opioid Use After Spinal Fusion for Adolescent Idiopathic Scoliosis.
    J Pediatr Orthop 2018 Jan 19. Epub 2018 Jan 19.
    Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, VA.
    Background: Opioids are commonly used after posterior spinal instrumented fusion (PSIF) for adolescent idiopathic scoliosis (AIS). Prescription opioids use can potentially lead to misuse, abuse, dependence, and overdose death. Prolonged opioid use has not been extensively studied in the postoperative AIS population. Read More

    Obesity and inflammatory bowel disease: diagnostic and therapeutic implications.
    Curr Opin Gastroenterol 2018 Jan 19. Epub 2018 Jan 19.
    University of Washington Medical Center.
    Purpose Of Review: The review summarizes our current understanding of how obesity impacts diagnostic studies and therapies used in inflammatory bowel disease (IBD) as well as the safety and efficacy of medical and surgical weight loss therapies in the obese IBD patient.

    Recent Findings: Many of the diagnostic tools we rely on in the identification and monitoring of IBD can be altered by obesity. Obesity is associated with increased acute phase proteins and fecal calprotectin. Read More

    A response to "A critical analysis of obesity prevention policies and strategies".
    Can J Public Health 2018 Jan 22;108(5-6):e630-e632. Epub 2018 Jan 22.
    Applied Human Nutrition, Mount Saint Vincent University, Halifax, NS.
    This commentary provides a response to the article "A critical analysis of obesity prevention policies and strategies" from a feminist fat studies perspective. We argue that a fundamental disjuncture exists between the authors' desire to redress fat stigma, and their understanding of "obesity as disease", which inherently draws on a neoliberal, healthist paradigm of health and body weight that is at the root of fat stigma. Read More

    A critical analysis of obesity prevention policies and strategies.
    Can J Public Health 2018 Jan 22;108(5-6):e598-e608. Epub 2018 Jan 22.
    Centre for Health Promotion Studies, School of Public Health, University of Alberta, Edmonton, AB.
    Objectives: Public health policies have been criticized for promoting a simplistic narrative that may contribute to weight bias. Weight bias can impact population health by increasing morbidity and mortality. The objectives of this study were to: 1) critically analyze Canadian obesity prevention policies and strategies to identify underlying dominant narratives; 2) deconstruct dominant narratives and consider the unintended consequences for people with obesity; and 3) make recommendations to change dominant obesity narratives that may be contributing to weight bias. Read More

    Epidemiologic Evidence That Excess Body Weight Increases Risk of Cervical Cancer by Decreased Detection of Precancer.
    J Clin Oncol 2018 Jan 22:JCO2017753442. Epub 2018 Jan 22.
    Megan A. Clarke, Li C. Cheung, Nicolas Wentzensen, Julia C. Gage, Hormuzd A. Katki, Maria Demarco, and Mark Schiffman, National Cancer Institute, Bethesda; Brian Befano and John Schussler, Information Management Services, Calverton, MD; Barbara Fetterman, Walter K. Kinney, Thomas S. Lorey, and Nancy E. Poitras, Kaiser Permanente Medical Group, Berkeley, CA; Tina R. Raine-Bennett, Kaiser Permanente Northern California, Oakland, CA; and Philip E. Castle, Albert Einstein College of Medicine, Bronx, NY.
    Purpose Obesity has been inconsistently linked to increased cervical cancer incidence and mortality; however, the effect of obesity on cervical screening has not been explored. We investigated the hypothesis that increased body mass might decrease detection of cervical precancer and increase risk of cervical cancer even in women undergoing state-of-the-art screening. Methods We conducted a retrospective cohort study of 944,227 women age 30 to 64 years who underwent cytology and human papillomavirus DNA testing (ie, cotesting) at Kaiser Permanente Northern California (January 2003 to December 2015). Read More

    Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial.
    J Clin Oncol 2018 Jan 22:JCO2017757526. Epub 2018 Jan 22.
    Christina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Purpose Metabolic syndrome is associated with an increased risk of cardiovascular disease, type 2 diabetes, and breast cancer recurrence in survivors of breast cancer. This randomized controlled trial assessed the effects of a 16-week combined aerobic and resistance exercise intervention on metabolic syndrome, sarcopenic obesity, and serum biomarkers among ethnically diverse, sedentary, overweight, or obese survivors of breast cancer. Methods Eligible survivors of breast cancer (N = 100) were randomly assigned to exercise (n = 50) or usual care (n = 50). Read More

    The gap between behavioral risk status and willingness to change behavior among healthcare professionals.
    Perspect Public Health 2018 Jan 1:1757913917751564. Epub 2018 Jan 1.
    Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyväskylä, Finland.
    Aims: This study explored behavioral health risk factors among healthcare professionals and investigated the at-risk persons' satisfaction with their health habits and ongoing change attempts.

    Methods: The study was based on a cross-sectional web-based survey directed at the nurses and physicians ( N = 1233) in Finnish healthcare. Obesity, low physical activity, smoking, and risky alcohol drinking were used as behavioral health risk factors. Read More

    Comparison of Antiobesity Effects Between Gochujangs Produced Using Different Koji Products and Tabasco Hot Sauce in Rats Fed a High-Fat Diet.
    J Med Food 2018 Jan 22. Epub 2018 Jan 22.
    1 Department of Food and Nutrition, Chosun University , Gwangju, Korea.
    In this study, we compared the antiobesity effects between gochujangs prepared using different koji products and Tabasco hot sauce in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were fed HFD containing four different types of 10% gochujang powder or 0.25% commercial Tabasco sauce powder for 8 weeks. Read More

    Computed tomographic evaluation of the thymus - Does obesity affect thymic fatty involution in a healthy young adult population?
    Br J Radiol 2018 Jan 22. Epub 2018 Jan 22.
    2 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Objective: To determine a relationship between increased body mass index (BMI) and fatty involution of the thymus in subjects aged between 20-30 years.

    Methods: CT images of 94 patients aged between 20-30 years were reviewed. Quantitative thymic mean attenuation was recorded and qualitative thymic attenuation was assigned to 1 of 4 possible grades. Read More

    Impact of body mass index on the oncological outcomes of patients with upper and lower urinary tract cancers treated with radical surgery: A multi-institutional retrospective study.
    Asia Pac J Clin Oncol 2018 Jan 22. Epub 2018 Jan 22.
    Department of Urology, Kitasato University School of Medicine, Kanagawa, Japan.
    Aim: To evaluate the impact of body mass index (BMI) on the oncological outcomes of urothelial carcinoma (UC) patients.

    Patients And Methods: We retrospectively analyzed data from 818 patients with upper tract urothelial cancer (UTUC) and bladder cancer (BC) who were treated with radical nephroureterectomy (RNU) or radical cystectomy (RC) between 1990 and 2015 at six different institutions in Japan. Patients with distant metastasis at diagnosis and those who received neoadjuvant therapies were excluded, leaving 727 eligible patients (UTUC: n = 441; BC: n = 286). Read More

    How adolescents decide on bariatric surgery: an interpretative phenomenological analysis.
    Clin Obes 2018 Jan 21. Epub 2018 Jan 21.
    Child and Adolescent Psychological Medicine, University College London Hospitals, NHS Foundation Trust, London, UK.
    The National Institute of Clinical Excellence states that bariatric surgery may be considered for adolescents with severe obesity in 'exceptional circumstances'. However, it is not clear what is deemed to be exceptional, and there is a lack of long-term outcomes data or research, which would inform patient selection. This is an in-depth qualitative study involving five adolescents who had previously undergone bariatric surgery (between 1 and 3 years postoperatively) and four who were being assessed for the treatment. Read More

    Utility values for childhood obesity interventions: a systematic review and meta-analysis of the evidence for use in economic evaluation.
    Obes Rev 2018 Jan 21. Epub 2018 Jan 21.
    Deakin Health Economics, Global Obesity Centre (GLOBE), Centre for Population Health Research, Deakin University, Geelong, Victoria, Australia.
    Rigorous estimates of preference-based utilities are important inputs into economic evaluations of childhood obesity interventions, yet no published review currently exists examining utility by weight status in paediatric populations. A comprehensive systematic literature review and meta-analysis was therefore undertaken, pooling data on preference-based health state utilities by weight status in children using a random-effects model. Tests for heterogeneity were performed, and publication bias was assessed. Read More

    Testosterone a key factor in gender related metabolic syndrome.
    Obes Rev 2018 Jan 21. Epub 2018 Jan 21.
    Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
    Metabolic syndrome (MetS) is highly correlated with cardiovascular diseases. Although an excess of body fat is a determinant factor for MetS development, a reduced level of testosterone plays a fundamental role in its regulation. Low testosterone level is highly related to insulin resistance, visceral obesity and MetS. Read More

    A multicenter, prospective, observational study examining the impact of risk factors, such as BMI and waist circumference, on quality of life improvement and clinical response in moderate-to-severe plaque-type psoriasis patients treated with infliximab in routine care settings of Greece.
    J Eur Acad Dermatol Venereol 2018 Jan 22. Epub 2018 Jan 22.
    1st Department of Dermatology, A. Syggros Hospital, University of Athens, Athens, Greece.
    Background: Obesity has been associated with moderate-to-severe plaque psoriasis severity and PASI 75 response attainment of biologic therapies, but findings are inconsistent.

    Objective: This study aimed to examine the association of body mass index (BMI) and waist circumference (WC) on disease severity, to identify potential patient characteristics associated with response attainment, and to assess the impact of infliximab on the patients' health-related quality of life (HRQoL) among infliximab-treated patients in the routine care setting of Greece.

    Methods: This was a multicenter, prospective, observational study of adult moderate-to-severe plaque psoriasis patients who had initiated treatment with originator infliximab within 2 weeks prior to enrollment. Read More

    Mouldable, thermoplastic, glue-on frog-supportive shoes change hoof kinetics in normal and obese Shetland ponies.
    Equine Vet J 2018 Jan 21. Epub 2018 Jan 21.
    Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University Yalelaan, 112-114, NL-3584 CM, Utrecht, The Netherlands.
    Background: Obesity and hyperinsulinaemia are frequently encountered in the equine population and risk factors for the development of laminitis. There are many options for hoof support that claim a beneficial effect, but often the scientific evidence is scarce.

    Objectives: To quantify the effect of frog-supportive shoes on hoof kinetics in normal and obese ponies. Read More

    Effect of body mass index on survival after sudden cardiac arrest.
    Clin Cardiol 2018 Jan 22. Epub 2018 Jan 22.
    Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
    Background: Although elevated body mass index (BMI) is a risk factor for cardiac disease, patients with elevated BMI have better survival in the context of severe illness, a phenomenon termed the "obesity paradox."

    Hypothesis: Higher BMI is associated with lower mortality in sudden cardiac arrest (SCA) survivors.

    Methods: Data were collected on 1433 post-SCA patients, discharged alive from the hospitals of the University of Pittsburgh Medical Center between 2002 and 2012. Read More

    Endurance exercise prevents high-fat-diet induced locomotor impairment, cardiac dysfunction, lifespan shortening, and dSir2 expression decline in aging Drosophila.
    Exp Gerontol 2018 Jan 16. Epub 2018 Jan 16.
    Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, City Chang Sha 410012, Province Hunan, China.
    High-Fat-Diet (HFD)-induced obesity is a major contributor to premature senescence in both Drosophila and humans, which includes locomotor impairment, cardiac dysfunction, and decrease in lifespan. While, few studies have shown that HFD could affect the expression dSir2 genes since the dSir2 genes are closely related to aging. As we know, endurance exercise can efficiently prevent obesity and delay age-related functional decline in Drosophila and humans. Read More

    Improving Follow-up and Reducing Barriers for Eye Screenings in Communities: the SToP Glaucoma Study.
    Am J Ophthalmol 2018 Jan 17. Epub 2018 Jan 17.
    Dana Center for Preventive Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:
    Purpose: To evaluate factors associated with attendance to follow-up ophthalmic care, and to assess the impact of strategies to improve follow-up.

    Design: Cross-sectional study.

    Methods: This is an ongoing study to develop an eye screening paradigm, focusing on African Americans ≥50 years of age at multiple urban community sites in Baltimore, MD. Read More

    A metagenomics approach to the intestinal microbiome structure and function in high fat diet-induced obesity mice fed with oolong tea polyphenols.
    Food Funct 2018 Jan 22. Epub 2018 Jan 22.
    Department of Agriculture and Biotechnology, Wenzhou Vocational College of Science and Technology, Wenzhou 325006, P.R. China.
    To investigate the modulatory effect of oolong tea polyphenols (OTP) on intestinal microbiota, OTP was prepared by column chromatography and its influence on the gut flora structure was analyzed by high-throughput sequencing with a human flora-associated high fat diet (HFD) induced obesity mouse model. We observed a robust increase in bacterial biodiversity and the abundance of genera known to be butyrate- and acetate-producing bacteria. A large increase in Bacteroidetes with a decrease in Firmicutes was observed after the administration of OTP for 4 weeks, and the corresponding decrease in the Firmicutes/Bacteroidetes ratio reflected the positive modulatory effect of OTP on the intestinal microbiota. Read More

    The impact of maternal body mass index on external cephalic version success.
    J Matern Fetal Neonatal Med 2018 Jan 21:1-7. Epub 2018 Jan 21.
    a Department of Obstetrics and Gynaecology , University of Maryland Medical Center , Baltimore , MD , USA.
    Objective: The purpose of this study is to determine the association between body mass index (BMI) and success of ECV.

    Methods: This is a cross-sectional analysis of singleton live births in the USA from 2010 to 2014 using birth certificate data. Patients were assigned a BMI category according to standard WHO classification. Read More

    The future of type 1 cannabinoid receptor allosteric ligands.
    Drug Metab Rev 2018 Jan 21:1-12. Epub 2018 Jan 21.
    a College of Pharmacy and Nutrition , University of Saskatchewan , Saskatoon , Canada.
    Allosteric modulation of the type 1 cannabinoid receptor (CB1R) holds great therapeutic potential. This is because allosteric modulators do not possess intrinsic efficacy, but instead augment (positive allosteric modulation) or diminish (negative allosteric modulation) the receptor's response to endogenous ligand. Consequently, CB1R allosteric modulators have an effect ceiling which allows for the tempering of CB1R signaling without the desensitization, tolerance, dependence, and psychoactivity associated with orthosteric compounds. Read More

    [Effect of acupuncture on macrophage polarization of white adipose tissue in obese mice induced by high-fat diet].
    Zhongguo Zhen Jiu 2017 Nov;37(11):1205-11
    College of Acupuncture and Orthopedics, Hubei University of CM; Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Wuhan 430061.
    Objective: To observe the effect of acupuncture at acupoints and non-acupoints on macrophage polarization of white adipose tissue in obese mice induced by high-fat diet(HFD).

    Methods: Fifty male C57BL/6 mice were randomly divided into a control group (n=10), and other mice were fed with HFD for 16 weeks to establish model. Thirty model mice, which were successfully established and continuously fed with HFD for 8 weeks, were randomized into a model group, a non-acupoint group and an acupuncture group (n=10/group). Read More

    [Skin needle embedding for obese impaired glucose tolerance].
    Zhongguo Zhen Jiu 2018 Jan;38(1):12-6
    Department of TCM, Beijing Fengsheng Special Hospital of Traditional Medical Traumatology and Orthopaedics, Beijing 100033, China.
    Objective: To explore the effect difference between the skin needle embedding therapy and western medication for obese impaired glucose tolerance (IGT).

    Methods: A total of 300 cases of obese IGT were assigned into an embedding group and a western medication group by random number table, 150 cases in each one. Standardized diagnosis and treatment programs were applied to reduce blood pressure, lipid, weight, and exercise and scientific diet management were used. Read More

    [Effects of laparoscopic sleeve gastrectomy on insulin secretion patterns in morbidly obese patients].
    Zhonghua Wei Chang Wai Ke Za Zhi 2018 Jan;21(1):61-67
    Department of Endocrinology and Metabolism, The Affiliated Shanghai No.10 People's Hospital, Nanjing Medical University, Shanghai 200072, China.
    Objective: To assess the effects of laparoscopic sleeve gastrectomy (LSG) on insulin secretion mode and metabolism of glucose and lipid in morbidly obese patients.

    Methods: Clinical data of 65 morbidly obese patients [body mass index (BMI) ≥30 kg/m2] undergoing LSG at Shanghai 10th People's Hospital from August 2012 to December 2016 were retrospectively analyzed. According to the result of OGTT, these obese patients were divided into three groups: normal glucose tolerance (NGT, 23 cases), impaired glucose tolerance (IGT, 22 cases) and type 2 diabetes mellitus (DM, 20 cases) groups. Read More

    Clinical characteristics associated with subcutaneous tophi formation in Chinese gout patients: a retrospective study.
    Clin Rheumatol 2018 Jan 22. Epub 2018 Jan 22.
    The Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, 16 Jiangsu Rd, Qingdao, 266003, China.
    The objective of this study is to analyze clinical characteristics associated with the formation of subcutaneous tophi among Chinese gout patients. It was a retrospective outpatient cohort study. Five thousand six hundred ninety-three gout patients treated at the Affiliated Hospital of Qingdao University from March 2011 to February 2016 were included and divided into the tophus group and non-tophus group according to the presence of megascopic tophus. Read More

    Risk of Obstructive Sleep Apnoea is Associated with Glycaemia Status in South Asian Men and Women in the United States.
    Obes Med 2018 Mar 1;9:1-6. Epub 2017 Dec 1.
    Epidemiology & Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, CA 94115.
    Aims: To examine the association between glycaemia status and the risk for obstructive sleep apnoea (OSA) in a cohort of South Asians living in the United States.

    Methods: A secondary analysis of a community based cohort of 899 participants from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. The Berlin Questionnaire was used to screen for OSA. Read More

    A systematic review of childhood obesity in the Middle East and North Africa (MENA) region: Prevalence and risk factors meta-analysis.
    Adv Pediatr Res 2017 15;4. Epub 2017 Jun 15.
    Epidemiology Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
    Obesity rates are rising globally, but there is evidence that young people in the Middle East and North Africa (MENA) region are at particularly high risk. We systematically searched the literature to map the MENA region for prevalence of childhood overweight and obesity, and examine the underlying risk factors and adverse effects associated with obesity in this region. Inclusion criteria were: English-language, non-basic-science focused articles that used any of the standard obesity definitions and were conducted in the MENA countries within the last five years. Read More

    Role Identification of Passiflora Incarnata Linnaeus: A Mini Review.
    J Menopausal Med 2017 Dec 29;23(3):156-159. Epub 2017 Dec 29.
    Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea.
    Some species of traditional herbal medicine has a history of use, most traditional natural herbs have been used for various diseases such as diabetes, hypertension, and obesity. Among them, Passiflora incarnata L. is a traditional natural medicine, flowers as well as berries, roots, and leaves have been used as a medicine. Read More

    Shortness of breath in clinical practice: A case for left atrial function and exercise stress testing for a comprehensive diastolic heart failure workup.
    World J Methodol 2017 Dec 26;7(4):117-128. Epub 2017 Dec 26.
    Cardiovascular Research, University of Melbourne, Melbourne, VIC 3076, Australia.
    The symptom cluster of shortness of breath (SOB) contributes significantly to the outpatient workload of cardiology services. The workup of these patients includes blood chemistry and biomarkers, imaging and functional testing of the heart and lungs. A diagnosis of diastolic heart failure is inferred through the exclusion of systolic abnormalities, a normal pulmonary function test and normal hemoglobin, coupled with diastolic abnormalities on echocardiography. Read More

    Effect of Obesity on Blood Pressure and Arterial Stiffness in Middle-Aged Korean Women.
    Osong Public Health Res Perspect 2017 Dec 31;8(6):369-372. Epub 2017 Dec 31.
    Department of Physical Education, Pusan National University, Busan, Korea.
    Objectives: Our study aims to provide basic scientific data on the importance of obesity management in middle-aged Korean women by analyzing its effects on blood pressure and arterial stiffness. In addition, we examined the correlations of these two parameters.

    Methods: The study participants were 40 middle-aged female volunteers, who were classified into obesity group (n = 20) and normal weight group (n = 20). Read More

    Hypertension, diabetes and obesity are associated with lower cognitive performance in community-dwelling elderly: Data from the FIBRA study.
    Dement Neuropsychol 2017 Oct-Dec;11(4):398-405
    Post-Graduate Program in Gerontology - Faculty of Medical Sciences, State University of Campinas - Unicamp, Campinas, SP, Brazil.
    Background: Systemic hypertension (SH), diabetes mellitus (DM) and abdominal obesity may negatively impact cognitive performance.

    Objective: To evaluate the association between SH, DM and abdominal obesity and cognitive performance among cognitively unimpaired elderly.

    Methods: A cross-sectional study of individuals aged 65+ from seven Brazilian cities was conducted. Read More

    Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility.
    Front Physiol 2017 4;8:1117. Epub 2018 Jan 4.
    Shanghai Key Laboratory for Reproductive Medicine, Department of Histology Embryology, Genetics and Developmental Biology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Obesity is frequently accompanied with chronic inflammation over the whole body and is always associated with symptoms that include those arising from metabolic and vascular alterations. On the other hand, the chronic inflammatory status in the male genital tract may directly impair spermatogenesis and is even associated with male subfertility. However, it is still unclear if the chronic inflammation induced by obesity damages spermatogenesis in the male genital tract. Read More

    Weight Status, Physical Activity, and Depression in Korean Older Adults.
    J Epidemiol 2018 Jan 20. Epub 2018 Jan 20.
    College of Sport Science, Sungkyunkwan University.
    Background: This study aimed to explore the associations between weight status, physical activity, and depression in Korean older adults.

    Methods: We used the baseline data drawn from the 2008 baseline survey utilized in the Living Profiles of Older People Survey, comprised of 15,146 community-dwelling older people (42.6% men and 57. Read More

    Diet in women with breast cancer compared to healthy controls - What is the difference?
    Eur J Oncol Nurs 2018 Feb 24;32:20-24. Epub 2017 Nov 24.
    Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway. Electronic address:
    Purpose: After a cancer diagnosis, patients often change their lifestyle in order to improve health. The aim of this study was to examine whether women with breast cancer had changed their diet two years after the diagnosis, and to compare their diet with that of healthy female blood donors.

    Methods: Patients (n = 180), median age 58 years (range 37-78), and 101 controls, median age 57 years (age 43-75) answered questions about consumption of alcohol, 36 different food items, and information like age, body mass index (BMI), marital status, and years of education. Read More

    Eating behavior traits of successful weight losers during 12 months of alternate-day fasting: An exploratory analysis of a randomized controlled trial.
    Nutr Health 2018 Jan 1:260106017753487. Epub 2018 Jan 1.
    1 Department of Kinesiology and Nutrition, University of Illinois at Chicago, USA.
    Background: Alternate-day fasting (ADF) has gained popularity in recent years. The diet consists of a "fast day" where an individual consumes 0-25% of their energy needs, alternated with a "feast day" where a person is permitted to eat ad libitum.

    Aim: This study examined eating behavior traits of successful weight losers during alternate day fasting. Read More

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