301,396 results match your criteria Obesity


Time Trends in Age at Menarche and Related Non-Communicable Disease Risk during the 20th Century in Mexico.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Division of Human Nutrition and Health, Wageningen University and Research, 6708WE Wageningen, The Netherlands.

Developed countries have shown a time trend towards a younger age at menarche (AAM), which is associated with increased risk of later obesity and non-communicable diseases. This study aimed to assess whether a time trend in AAM is associated with disease risk in Mexican women ( = 30,826), using data from the Mexican National Health Survey (2000). Linear and log binomial regression was used for nutritional and disease outcomes, while Welch⁻ANOVA was used to test for a time trend. Read More

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http://dx.doi.org/10.3390/nu11020394DOI Listing
February 2019

Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease.

Diseases 2019 Feb 13;7(1). Epub 2019 Feb 13.

Division of Nephrology, Department of Medicine, University of California-Irvine, Irvine, CA 92697, USA.

Chronic kidney disease (CKD) is a worldwide major health problem. Traditional risk factors for CKD are hypertension, obesity, and diabetes mellitus. Recent studies have identified gut dysbiosis as a novel risk factor for the progression CKD and its complications. Read More

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http://dx.doi.org/10.3390/diseases7010021DOI Listing
February 2019

A Systematic Review of the Association of Skipping Breakfast with Weight and Cardiometabolic Risk Factors in Children and Adolescents. What Should We Better Investigate in the Future?

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

SCDU of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.

The incidence of skipping breakfast in pediatric subjects is rising, and a relationship with overweight (OW) and obesity (OB) has been shown. Associations with cardiovascular outcomes and skipping breakfast in adults have been reported. The purpose of this systematic review was to summarize the association of skipping breakfast with body weight and metabolic outcomes in the pediatric population. Read More

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http://dx.doi.org/10.3390/nu11020387DOI Listing
February 2019

Short-Term Neonatal Oral Administration of Oleanolic Acid Protects against Fructose-Induced Oxidative Stress in the Skeletal Muscles of Suckling Rats.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.

Nutritional manipulations in the neonatal period are associated with the development of negative or positive health outcomes later in life. Excessive fructose consumption has been attributed to the increase in the global prevalence of metabolic syndrome (MetS) and the development of oxidative stress. Oleanolic acid (OA) has anti-diabetic and anti-obesity effects. Read More

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http://dx.doi.org/10.3390/molecules24040661DOI Listing
February 2019

Double Discourse: Qualitative Perspectives on Breast Screening Participation among Obese Women and Their Health Care Providers.

Int J Environ Res Public Health 2019 Feb 13;16(4). Epub 2019 Feb 13.

Translational Health Research Institute (THRI), Western Sydney University, Penrith, NSW 2750, Australia.

Obesity in Australia is rising rapidly, and is a major public health concern. Obesity increases the risk of breast cancer and worsens associated outcomes, yet breast screening participation rates in Australia are suboptimal and can be lower in higher risk, obese women. This study qualitatively explored barriers to breast screening participation in obese women in Australia. Read More

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http://dx.doi.org/10.3390/ijerph16040534DOI Listing
February 2019

Effectiveness of an Intervention of Dietary Counseling for Overweight and Obese Pregnant Women in the Consumption of Sugars and Energy.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Institute of Nutrition and Food Technology (INTA), University of Chile, 7830490 Santiago, Chile.

Objective: Evaluate if an intervention based on nutritional counseling decreases total sugars and energy consumption in overweight and obese pregnant women, compared to their previous consumption and compared to women who only received routine counseling.

Methods: Randomized study of two groups: dietary counseling (Intervention Group: IG) and routine counseling (Control Group: CG). The intervention consisted of three educational sessions focused on decreasing intake of foods that most contribute to sugars consumption. Read More

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http://dx.doi.org/10.3390/nu11020385DOI Listing
February 2019

Sleep, Autonomic Nervous Function and Atherosclerosis.

Int J Mol Sci 2019 Feb 13;20(4). Epub 2019 Feb 13.

Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.

Behavioral and psychosocial factors related to development of cardiovascular disease have been gaining increased attention. Notably, sleep is considered to be one of the most important behavioral factors involved in progression of atherosclerosis and cardiovascular events, with autonomic nervous function a potential mechanism. Several studies have shown associations of sleep and autonomic dysfunction with major surrogate markers of atherosclerosis, such as carotid intima-media thickness and arterial stiffness. Read More

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http://dx.doi.org/10.3390/ijms20040794DOI Listing
February 2019

Association between Availability of Neighborhood Fast Food Outlets and Overweight Among 5⁻18 Year-Old Children in Peninsular Malaysia: A Cross-Sectional Study.

Int J Environ Res Public Health 2019 Feb 18;16(4). Epub 2019 Feb 18.

Institute for Medical Research, Jalan Pahang, Ministry of Health, Kuala Lumpur 50588, Malaysia.

A growing number of fast-food outlets in close proximity to residential areas raises a question as to its impact on childhood overweight and obesity. This study aimed at determining the relationship between the availability of fast-food outlets that were in close proximity to residential areas and overweight among Malaysian children aged 5 to 18 years. Measurement data on the weight and height of 5544 children (2797 boys, 2747 girls) were obtained from the National Health and Morbidity Survey 2011. Read More

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http://dx.doi.org/10.3390/ijerph16040593DOI Listing
February 2019

New Metabolic Influencer on Oxytocin Release: The Ghrelin.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary.

Background: The hypothalamic⁻pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Read More

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http://dx.doi.org/10.3390/molecules24040735DOI Listing
February 2019

Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia.

Molecules 2019 Feb 17;24(4). Epub 2019 Feb 17.

College of Traditional Mongolian Medicine, Inner Mongolia Uaniversity for Nationalities, Tongliao 028000, China.

L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. Read More

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http://dx.doi.org/10.3390/molecules24040725DOI Listing
February 2019

Diurnal Patterns of Energy Intake Derived via Principal Component Analysis and Their Relationship with Adiposity Measures in Adolescents: Results from the National Diet and Nutrition Survey RP (2008⁻2012).

Nutrients 2019 Feb 17;11(2). Epub 2019 Feb 17.

Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle NE1 8ST, UK.

Mounting evidence points towards the existence of an association between energy intake in the evening and an increased prevalence and risk of being overweight and of obesity. The present study aimed to describe diurnal eating patterns (DEP) in a nationally representative sample of UK adolescents and to relate the derived DEP to anthropometrical measures. Data from four-day food records of adolescents aged 11⁻18 years participating in the 2008⁻2012 UK National Diet and Nutrition Survey Rolling Programme (NDNS RP) was utilised. Read More

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http://dx.doi.org/10.3390/nu11020422DOI Listing
February 2019

The Obemat2.0 Study: A Clinical Trial of a Motivational Intervention for Childhood Obesity Treatment.

Nutrients 2019 Feb 16;11(2). Epub 2019 Feb 16.

Pediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, IISPV, 43201 Reus, Spain.

The primary aim of the Obemat2.0 trial was to evaluate the efficacy of a multicomponent motivational program for the treatment of childhood obesity, coordinated between primary care and hospital specialized services, compared to the usual intervention performed in primary care. This was a cluster randomized clinical trial conducted in Spain, with two intervention arms: motivational intervention group vs. Read More

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http://dx.doi.org/10.3390/nu11020419DOI Listing
February 2019

The Association between Plasma Omega-6/Omega-3 Ratio and Anthropometric Traits Differs by Racial/Ethnic Groups and Genotypes in Healthy Young Adults.

J Pers Med 2019 Feb 16;9(1). Epub 2019 Feb 16.

School of Nutrition Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Evidence for a relationship between omega-6/omega-3 (n-6/n-3) polyunsaturated fatty acid (PUFA) ratio and obesity in humans is inconsistent, perhaps due to differences in dietary intake or metabolism of PUFAs between different subsets of the population. Since chronic inflammation is central to obesity and inflammatory pathways are regulated by PUFAs, the objective of this study was to examine whether variants in the gene, an upstream regulator of the inflammatory response, modify the association between the n-6/n-3 ratio (from diet and plasma) and anthropometric traits in a multiethnic/multiracial population of young adults. Participants' ( = 898) dietary PUFA intake was assessed using a food frequency questionnaire and plasma PUFA concentrations by gas chromatography. Read More

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http://dx.doi.org/10.3390/jpm9010013DOI Listing
February 2019

Impact of a Usual Serving Size of Flavanol-Rich Cocoa Powder Ingested with a Diabetic-Suitable Meal on Postprandial Cardiometabolic Parameters in Type 2 Diabetics-A Randomized, Placebo-Controlled, Double-Blind Crossover Study.

Nutrients 2019 Feb 16;11(2). Epub 2019 Feb 16.

Faculty of Food, Nutrition and Hospitality Sciences, Hochschule Niederrhein, University of Applied Sciences, Rheydter Str. 277, 41065 Mönchengladbach, Germany.

Randomized controlled trials indicate that flavanol-rich cocoa intake may improve postprandial glucose and lipid metabolism in patients with type 2 diabetes (T2D), based on studies with meals that impose a strong metabolic load. Hence, the aim of the present study was to investigate whether flavanol-rich cocoa powder ingested as part of a diabetic-suitable meal may beneficially affect glucose, lipid metabolism, and blood pressure (BP) in patients with T2D. Twelve adults with T2D, overweight/obesity, and hypertension ingested capsules with 2. Read More

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http://dx.doi.org/10.3390/nu11020417DOI Listing
February 2019

Assessment of Packaged Foods and Beverages Carrying Nutrition Marketing against Canada's Food Guide Recommendations.

Nutrients 2019 Feb 15;11(2). Epub 2019 Feb 15.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.

Canadians' food purchases consist largely of packaged processed and ultra-processed products, which typically fall outside the "core" foods recommended by Canada's Food Guide (CFG). Almost half of packaged products in Canada carry nutrition marketing (i.e. Read More

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http://dx.doi.org/10.3390/nu11020411DOI Listing
February 2019

Adiponectin as Link Factor between Adipose Tissue and Cancer.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso 86100, Italy.

Adipose tissue is a key regulator of energy balance playing an active role in lipid storage as well as in synthesizing several hormones directly involved in the pathogenesis of obesity. Obesity represents a peculiar risk factor for a growing list of cancers and is frequently associated to poor clinical outcome. The mechanism linking obesity and cancer is not completely understood, but, amongst the major players, there are both chronic low-grade inflammation and deregulation of adipokines secretion. Read More

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http://dx.doi.org/10.3390/ijms20040839DOI Listing
February 2019

Lower Extremity Blood Flow Velocity in Obese versus Nonobese Pregnant Women.

Am J Perinatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas.

Background:  Obesity and pregnancy are risk factors for venous thromboembolism (VTE). In nonpregnant individuals, abdominal obesity is associated with venous insufficiency.

Objective:  To compare venous Doppler volume flow and velocity in the lower extremities of obese versus nonobese women. Read More

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http://dx.doi.org/10.1055/s-0039-1679867DOI Listing
February 2019

Evaluation of metformin therapy using controlled attenuation parameter and transient elastography in patients with non-alcoholic fatty liver disease.

Pharmacol Rep 2018 Oct 26;71(2):183-188. Epub 2018 Oct 26.

Department of Internal Medicine and Metabolic Diseases, School of Health Sciences, Medical University of Silesia, Katowice, Poland.

Background: Non-alcoholic fatty liver disease (NAFLD) is among the most common causes of liver disease worldwide. There is growing evidence on pathogenesis and pathophysiology of NAFLD. However, there is still no universally accepted pharmacotherapy protocol. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.10.013DOI Listing
October 2018

Aryl hydrocarbon receptor (AHR) functions in NAD metabolism, myelopoiesis and obesity.

Authors:
Karl Walter Bock

Biochem Pharmacol 2019 Feb 16;163:128-132. Epub 2019 Feb 16.

Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Wilhelmstrasse 56, D-72074 Tübingen, Germany. Electronic address:

Diverse physiologic functions of AHR, a transcription factor discovered in studies of dioxin toxicity, are currently elucidated in many laboratories including chemical and microbial defense, immunity and myelopoiesis. Accumulating evidence suggests that AHR may also be involved in obesity and TCDD-mediated lethality in sensitive species. Underlying mechanisms include NAD- and sirtuin-mediated deregulation of lipid, glucose and NAD homeostasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00062952193005
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http://dx.doi.org/10.1016/j.bcp.2019.02.021DOI Listing
February 2019
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Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity.

FASEB J 2019 Feb 19:fj201802328R. Epub 2019 Feb 19.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

Growth hormone (GH) has an important function as an insulin antagonist with elevated insulin sensitivity evident in humans and mice lacking a functional GH receptor (GHR). We sought the molecular basis for this sensitivity by utilizing a panel of mice possessing specific deletions of GHR signaling pathways. Metabolic clamps and glucose homeostasis tests were undertaken in these obese adult C57BL/6 male mice, which indicated impaired hepatic gluconeogenesis. Read More

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http://dx.doi.org/10.1096/fj.201802328RDOI Listing
February 2019

Association of Periodontitis with Oral Cancer: A Case-Control Study.

J Dent Res 2019 Feb 19:22034519827565. Epub 2019 Feb 19.

1 Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.

The association between oral squamous cell carcinoma (OSCC) and periodontitis in large hospital cases with cohort controls has yet to be evaluated. The aim of this study was to investigate the association of periodontitis with OSCC across tumor location and tumor-node-metastasis (TNM) stage among Koreans ( N = 424). OSCC cases ( n = 146) were recruited from Seoul National University Dental Hospital and matched by age, sex, and smoking to controls ( n = 278) from the Yangpyeong health and periodontal cohort in Korea. Read More

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http://dx.doi.org/10.1177/0022034519827565DOI Listing
February 2019

A high-fat diet aggravates osteonecrosis through a macrophage-derived IL-6 pathway.

Int Immunol 2019 Feb 19. Epub 2019 Feb 19.

Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Inflammation plays an important role in osteonecrosis. Obesity, a risk factor for osteonecrosis, leads to a chronic inflammatory status. We hypothesized that inflammation mediated the effects of obesity on osteonecrosis and tested our hypothesis in a mouse model of osteonecrosis. Read More

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http://dx.doi.org/10.1093/intimm/dxz002DOI Listing
February 2019

Management of Cardiovascular Disease in Women With Breast Cancer.

Circulation 2019 Feb;139(8):1110-1120

Division of Cardiology, MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Georgetown University, Washington, DC (A.B.).

Cardio-oncology is a rapidly developing field which seeks to improve patient outcomes through enhanced clinical and research collaboration across the disciplines of oncology and cardiology. Breast cancer (BC) is the most common cancer diagnosis among women in the United States and, as decades of research have resulted in decreased mortality rates, there has been an increasing focus on reducing short- and long-term treatment toxicity and improving morbidity among survivors. Preexisting or emergent cardiovascular disease in a patient with BC requires a multidisciplinary, team-based approach to balance the need for curative cancer treatment while preventing increased cardiovascular disease morbidity and mortality. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.039371DOI Listing
February 2019

Systemic bile acids induce insulin resistance in a TGR5-independent manner.

Am J Physiol Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

Department of Molecular Physiology and Biophysics Vanderbilt Univ. School of Medicine Nashville, TN, United States.

Bile acids are involved in the emulsification and absorption of dietary fats as well as acting as signaling molecules. Recently, bile acid signaling through farnesoid X receptor (FXR) and G Protein-Coupled Bile Acid Receptor (TGR5) has been reported to elicit changes in not only bile acid synthesis but also metabolic processes including altering gluconeogenic gene expression and energy expenditure. A role for bile acids in glucose metabolism is also supported by a correlation between changes in the metabolic state of patients (i. Read More

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http://dx.doi.org/10.1152/ajpendo.00362.2018DOI Listing
February 2019

Short sleep and low milk intake are associated with obesity in a community of school aged children from Argentina.

Am J Hum Biol 2019 Feb 19:e23224. Epub 2019 Feb 19.

Investigador Independiente, CONICET Instituto de Desarrollo e Investigaciones Pediátricas (IDIP-MS/CIC, PBA) Hospital de NIños Sor M. Ludovica La Plata ARGENTINA, Buenos Aires, Argentina.

Objectives: Understanding the factors related to obesity during childhood allows for improved preventive actions specifically adapted to particular communities. The purpose of this study was to identify individual and familiar factors related to obesity in children.

Methods: A cross-sectional study was conducted in an urban community in Argentina during the years 2015-2016. Read More

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http://dx.doi.org/10.1002/ajhb.23224DOI Listing
February 2019

Health behavior knowledge among Hispanic California islanders: Evaluation of a parental educational intervention.

J Spec Pediatr Nurs 2019 Feb 19:e12235. Epub 2019 Feb 19.

Department of Information Systems and Decision Sciences, California State University, Fullerton, California.

Purpose: To evaluate the impact of a school nurse-led pilot parent-focused education program for healthy eating and physical activity to reduce childhood obesity.

Design And Methods: A quasi-experimental intervention design was used to assess the knowledge of 11 Hispanic mothers regarding healthy food choices and physical activity over a period of 1 year.

Results: There was an improvement in parental knowledge domains. Read More

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http://dx.doi.org/10.1111/jspn.12235DOI Listing
February 2019

Comparison of Smartphone-Based Behavioral Obesity Treatment With Gold Standard Group Treatment and Control: A Randomized Trial.

Obesity (Silver Spring) 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, The Miriam Hospital/Weight Control and Diabetes Research Center, Providence, Rhode Island, USA.

Objective: This study aimed to determine whether weight losses from a primarily smartphone-based behavioral obesity treatment (SMART) differed from those of a more intensive group-based behavioral obesity treatment (GROUP) and a control condition (CONTROL).

Methods: A total of 276 adults with overweight/obesity were randomly assigned to 18 months of GROUP-based treatment with meetings weekly for 6 months, meetings biweekly for 6 months, and meetings monthly for 6 months and self-monitoring via paper diaries with written feedback; SMART-based treatment with online lessons, self-monitoring, and feedback plus monthly weigh-ins; or a CONTROL condition with self-monitoring via paper diaries with written feedback and monthly weigh-ins.

Results: Among the 276 participants (17% men; 7. Read More

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http://dx.doi.org/10.1002/oby.22410DOI Listing
February 2019

Cardiorespiratory fitness, body mass index and heart failure incidence.

Eur J Heart Fail 2019 Feb 19. Epub 2019 Feb 19.

Cardiology Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.

Aims: Obesity is associated with increased risk of heart failure (HF). This risk may be modulated by improved cardiorespiratory fitness (CRF) as CRF is associated with favourable health outcomes. Thus, we assessed the interaction between body mass index (BMI), CRF and HF. Read More

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http://dx.doi.org/10.1002/ejhf.1433DOI Listing
February 2019

Investigation of human apoB48 metabolism using a new, integrated non-steady-state model of apoB48- and apoB100 kinetics.

J Intern Med 2019 Feb 18. Epub 2019 Feb 18.

Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: Triglyceride-rich lipoproteins and their remnants have emerged as major risk-factors for cardiovascular disease. New experimental approaches are required that permit simultaneous investigation of the dynamics of chylomicrons (CM) and apoB48 metabolism and of apoB100 in very low density lipoproteins (VLDL).

Methods: Mass spectrometric techniques were used to determine the masses and tracer enrichments of apoB48 in the CM, VLDL and VLDL density intervals. Read More

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http://dx.doi.org/10.1111/joim.12877DOI Listing
February 2019

Taste, olfactory and texture related genes and food choices: implications on health status.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1305-1321

MAGI Euregio, Nonprofit Genetic Testing Laboratory, Bolzano, Italy.

Objective: The food choices are due to a mixture of sensory signals including gustatory, olfactory, and texture sensations. The aim of this quality review was to update data about studies concerning genetics of taste, olfactory and texture receptors and their influence on the health status in humans.

Materials And Methods: An electronic search was conducted in MEDLINE, Pubmed database and Scopus, for articles published in English until December 2018. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17026DOI Listing
February 2019

Mendelian obesity, molecular pathways and pharmacological therapies: a review.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1357-1378

MAGI'S Lab, Genetic Testing Laboratory, Rovereto (TN), Italy.

Objective: In this qualitative review we analyze the major pathways and mechanisms involved in the onset of genetically-determined obesity (Mendelian obesity), identifying possible pharmacological treatments and trials.

Materials And Methods: We searched PubMed with the keywords (obesity[Title/Abstract]) AND mutation[Title/Abstract], and OMIM with the keyword "obesity". In both cases, we selected non-syndromic Mendelian obesity. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17031DOI Listing
February 2019

Diet quality and eating patterns in euthymic bipolar patients.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1221-1238

Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.

Objective: As mood disorders and obesity are interrelated, and both are linked to increased morbidity and mortality, risk factors for obesity should be identified and closely monitored in patients with bipolar disorder (BD). The aim of this study was to determine the diet quality of BD patients and to investigate its putative associations with comorbid obesity and disorders of carbohydrate metabolism, as well as the relationship between diet and clinical features of BD.

Patients And Methods: Eating patterns in 113 euthymic BD patients and 160 healthy control subjects were assessed using data obtained from a food frequency questionnaire. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17016DOI Listing
February 2019

Nutrition and Ageing.

Subcell Biochem 2018 ;90:373-424

Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

The ageing trajectory is plastic and can be slowed down by lifestyle factors, including good nutrition, adequate physical activity and avoidance of smoking. In humans, plant-based diets such as the Mediterranean dietary pattern are associated with healthier ageing and lower risk of age-related disease, whereas obesity accelerates ageing and increases the likelihood of most common complex diseases including CVD, T2D, dementia, musculoskeletal diseases and several cancers. As yet, there is only weak evidence in humans about the molecular mechanisms through which dietary factors modulate ageing but evidence from cell systems and animal models suggest that it is probable that better dietary choices influence all 9 hallmarks of ageing. Read More

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http://dx.doi.org/10.1007/978-981-13-2835-0_13DOI Listing
January 2018

Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration.

Eur J Drug Metab Pharmacokinet 2019 Feb 18. Epub 2019 Feb 18.

Department of Clinical Pharmacy and Biopharmacy, Poznań University of Medical Sciences, ul. Św. Marii Magdaleny 14, 61-861, Poznań, Poland.

Background And Objectives: The number of overweight, obese and diabetic patients is constantly increasing. Metabolic disorders may affect the pharmacokinetics of drugs, e.g. Read More

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http://dx.doi.org/10.1007/s13318-019-00543-1DOI Listing
February 2019

Metabolic syndrome and gastrointestinal cancers.

Indian J Gastroenterol 2019 Feb 18. Epub 2019 Feb 18.

Yong Loo Lin School of Medicine, NUHS Tower Block, National University of Singapore, 1E Kent Ridge Road, Level 11, Singapore, 119228, Singapore.

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http://dx.doi.org/10.1007/s12664-019-00939-6DOI Listing
February 2019

Laparoscopic management of recurrent ventral hernia: an experience of 222 patients.

Hernia 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastrointestinal and Minimal Access Surgery, GEM Hospital and Research Centre, 45, Pankaja Mills Road, Ramanathapuram, Coimbatore, Tamil Nadu, 641045, India.

Background: To evaluate the predisposing factors and characteristics of recurrent ventral hernia (RVH) along with the feasibility and outcome of laparoscopy in managing RVH.

Methods: This study is a retrospective analysis of all patients with reducible or irreducible, uncomplicated RVH who underwent surgical management from January 2012 to June 2018.

Results: Out of 222 patients, 186 (83. Read More

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http://dx.doi.org/10.1007/s10029-019-01912-0DOI Listing
February 2019

A toddler with a novel LEPR mutation.

Hormones (Athens) 2019 Feb 18. Epub 2019 Feb 18.

Division of Pediatric Endocrinology, Faculty of Medicine, Dokuz Eylül University, 35340, Balçova, Izmir, Turkey.

There are numerous causes, such as environmental factors, medications, endocrine disorders, and genetic factors, that can lead to obesity. However, severe early-onset obesity with abnormal feeding behavior, mental retardation, dysmorphic features, organ-specific developmental abnormalities, and endocrine disorders suggest a genetic etiology. Mutations in genes related to the leptin-melanocortin pathway play a key role in genetic obesity. Read More

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http://dx.doi.org/10.1007/s42000-019-00097-6DOI Listing
February 2019

Obesity and anxiety symptoms: a systematic review and meta-analysis.

Neuropsychiatr 2019 Feb 18. Epub 2019 Feb 18.

Department of Psychology, Kharazmi University, Tehran, Iran.

Background: Obesity and anxiety are the two most common health problems and increased body mass index can be lead to anxiety.

Objective: The aim of this meta-analysis was to investigate the frequency of anxiety symptoms in people who are obese/overweight.

Methods: For this purpose the authors systematically searched keywords in the databases PubMed, Scopus, PsycINFO and Google scholar through August 2018. Read More

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http://dx.doi.org/10.1007/s40211-019-0302-9DOI Listing
February 2019

The population-based prevalence of hypertension and correlates of blood pressure among Australian children.

Pediatr Nephrol 2019 Feb 18. Epub 2019 Feb 18.

School of Public Health, University of Sydney, Sydney, New South Wales, Australia.

Objective: Hypertension is increasingly recognized as a disease spanning the entire life course. Continued efforts to refine the diagnosis and management of hypertension in children are highlighted by the recent American Academy of Pediatrics (AAP) guidelines, which include lower threshold values than the previous reference standard (Fourth Report). We aimed to determine the population-based prevalence of children exceeding thresholds for hypertension using these two guidelines. Read More

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http://link.springer.com/10.1007/s00467-019-04206-w
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http://dx.doi.org/10.1007/s00467-019-04206-wDOI Listing
February 2019
1 Read

Intestinal nerve cell injury occurs prior to insulin resistance in female mice ingesting a high-fat diet.

Cell Tissue Res 2019 Feb 18. Epub 2019 Feb 18.

Department of Biological Sciences, University of Idaho, 875 Perimeter Drive, LSS 252, Moscow, ID, 83844, USA.

Diabetic patients suffer from gastrointestinal disorders associated with dysmotility, enteric neuropathy and dysbiosis of gut microbiota; however, gender differences are not fully known. Previous studies have shown that a high-fat diet (HFD) causes type two diabetes (T2D) in male mice after 4-8 weeks but only does so in female mice after 16 weeks. This study seeks to determine whether sex influences the development of intestinal dysmotility, enteric neuropathy and dysbiosis in mice fed HFD. Read More

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http://dx.doi.org/10.1007/s00441-019-03002-0DOI Listing
February 2019

Maternal hypothyroidism and future pediatric neurological morbidity of the offspring.

Arch Gynecol Obstet 2019 Feb 18. Epub 2019 Feb 18.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, 151 Izak Rager Ave., 84101, Beer-Sheva, Israel.

Background: Maternal hypothyroidism in pregnancy has been associated with neurocognitive impairment in exposed children, ranging from psychomotor-developmental delay to lower IQ scores.

Objective: To investigate the long-term neurological morbidity of children to hypothyroid mothers during pregnancy.

Study Design: A population-based cohort study was performed including all deliveries occurring in a period of 20 years at a tertiary medical center. Read More

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http://dx.doi.org/10.1007/s00404-019-05092-1DOI Listing
February 2019

The outcomes of total knee arthroplasty in morbidly obese patients: a systematic review of the literature.

Arch Orthop Trauma Surg 2019 Feb 16. Epub 2019 Feb 16.

Royal London Hospital, Barts Health NHS Trust, Whitechapel, London, E1 1BB, UK.

Introduction: The increasing prevalence of obesity has led to an increase in total knee arthroplasties (TKAs) being undertaken in patients with a higher body mass index (BMI). TKA in morbidly obese patients can be technically challenging due to numerous anatomical factors and patient co-morbidities. The long-term outcomes in this patient group are unclear. Read More

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http://dx.doi.org/10.1007/s00402-019-03127-5DOI Listing
February 2019

Gestational Diabetes and Childhood Obesity-Reply.

JAMA 2019 Feb;321(7):708-709

Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2018.19754DOI Listing
February 2019

Gestational Diabetes and Childhood Obesity.

JAMA 2019 Feb;321(7):708

Imperial College London School of Medicine, London, England.

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http://dx.doi.org/10.1001/jama.2018.19750DOI Listing
February 2019

Correction: From white to beige adipocytes: therapeutic potential of dietary molecules against obesity and their molecular mechanisms.

Food Funct 2019 Feb 19. Epub 2019 Feb 19.

Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA.

Correction for 'From white to beige adipocytes: therapeutic potential of dietary molecules against obesity and their molecular mechanisms' by Siyu Wang et al., Food Funct., 2019, DOI: 10. Read More

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http://dx.doi.org/10.1039/c9fo90006cDOI Listing
February 2019

[Inverse correlation between psychotic disorders and tumor development].

Vertex 2018 Jul;XXIX(140):279-284

Servicio de Psiquiatría, Hospital Universitario Fundación Alcorcón, Madrid.

Patients suffering from psychotic disorders have an increased morbidity compared with control population. Moreover, these patients are prone to habits such as smoking or obesity, which in fact are risk factors for developing neoplasias.

Objective: The current study is aimed to determine the prevalence of oncologic processes (lung, colon and prostate cancer) among patients diagnosed with psychotic disorders. Read More

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MiR-27b-3p Inhibition Enhances Browning of Epididymal Fat in High-Fat Diet Induced Obese Mice.

Front Endocrinol (Lausanne) 2019 4;10:38. Epub 2019 Feb 4.

Division of Geriatric Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Long-term dysregulation of energy balance is the key component of the obesity epidemic. Given the harm of central obesity and the discovery that beige cells appear within white adipose tissue (WAT), enhancing the energy-expending or "browning" ability of visceral adipose tissue (VAT) has become of therapeutic interest. In this study, we focused on the regulating role of microRNA (miRNA)-27b-3p in mice epididymal white adipose tissue (eWAT) browning. Read More

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http://dx.doi.org/10.3389/fendo.2019.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369196PMC
February 2019

Interventions to Address Environmental Metabolism-Disrupting Chemicals: Changing the Narrative to Empower Action to Restore Metabolic Health.

Front Endocrinol (Lausanne) 2019 4;10:33. Epub 2019 Feb 4.

Department of Pediatrics, University of Michigan, Ann Arbor, MI, United States.

Metabolic disease rates have increased dramatically over the last four decades. Classic understanding of metabolic physiology has attributed these global trends to decreased physical activity and caloric excess; however, these traditional risk factors insufficiently explain the magnitude and rapidity of metabolic health deterioration. Recently, the novel contribution of environmental metabolism-disrupting chemicals (MDCs) to various metabolic diseases (including obesity, diabetes, and non-alcoholic fatty liver disease) is becoming recognized. Read More

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http://dx.doi.org/10.3389/fendo.2019.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369180PMC
February 2019

Behavioral Modeling in Weight Loss Interventions.

Eur J Oper Res 2019 Feb 29;272(3):1058-1072. Epub 2018 Jul 29.

Department of Physiological Nursing/Institute for Health and Aging, School of Nursing, University of fornia, San Francisco, CA 94143.

Designing systems with human agents is difficult because it often requires models that characterize agents' responses to changes in the system's states and inputs. An example of this scenario occurs when designing treatments for obesity. While weight loss interventions through increasing physical activity and modifying diet have found success in reducing individuals' weight, such programs are difficult to maintain over long periods of time due to lack of patient adherence. Read More

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http://dx.doi.org/10.1016/j.ejor.2018.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377177PMC
February 2019