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    Exposure to air pollution interacts with obesogenic nutrition to induce tissue-specific response patterns.
    Environ Pollut 2018 Apr 20;239:532-543. Epub 2018 Apr 20.
    Department of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel.
    Obesity and exposure to particular matter (PM) have become two leading global threats to public health. However, the exact mechanisms and tissue-specificity of their health effects are largely unknown. Here we investigate whether a metabolic challenge (early nutritional obesity) synergistically interacts with an environmental challenge (PM exposure) to alter genes representing key response pathways, in a tissue-specific manner. Read More

    A novel triazine ring compound (MD568) exerts in vivo and in vitro effects on lipid metabolism.
    Biomed Pharmacother 2018 Apr 20;103:790-799. Epub 2018 Apr 20.
    Academy of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510000, PR China. Electronic address:
    In this study, we investigated the toxicity and biological activity of a novel triazine ring compound named magnolol derivative 568 (MD568). The LD of MD568 was determined in Sprague-Dawley (SD) rats by intraperitoneal injection. Treatment of high fat diet-induced obese rats with MD568 demonstrated that MD568 displayed significant anti-obesity effects. Read More

    The Role of Promyelocytic Leukemia Protein in Steatosis-Associated Hepatic Tumors Related to Chronic Hepatitis B virus Infection.
    Transl Oncol 2018 Apr 20;11(3):743-754. Epub 2018 Apr 20.
    Department of Pathology and Laboratory Medicine, Koo Foundation Sun-Yat-Sen Cancer Center, Taipei 112, Taiwan.
    The persistence of hepatitis B surface antigen (HBsAg) is a risk factor for the development of steatosis-associated tumors in chronic hepatitis B virus (HBV) infection, yet little is known about the metabolic link with this factor. We correlated HBV-related pathogenesis in genetically engineered mice and human carriers with metabolic proteomics and lipogenic gene expression profiles. The immunohistochemistry showed that the promyelocytic leukemia protein (PML, a tumor suppressor involved in genome maintenance and fatty acid oxidation), being inversely influenced by the dynamic HBsAg levels from acute phase to seroclearance, appeared as a lipo-metabolic switch linking HBsAg-induced steatosis (lipogenesis) to HBsAg-lost fat-burning hepatocarcinogenesis (lipolysis). Read More

    Exercise as a therapeutic intervention to optimize fetal weight.
    Pharmacol Res 2018 Apr 20. Epub 2018 Apr 20.
    Program for Pregnancy and Postpartum Health, Faculty of Kinesiology, Sport and Recreation, 1-052 Li Ka Shing Centre for Health Research Innovation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, T6G 2E1, Alberta, Canada. Electronic address:
    The Developmental Origins of Health and Disease suggest the in utero environment programs offspring obesity and cardiovascular disease. Therefore, there is a need to implement safe therapeutic interventions that do not involve the intake of medications or biological products during pregnancy that can improve maternal and fetal health. Prenatal exercise is established to promote maternal and fetal health. Read More

    Age and gender associations with systemic corticosteroid-induced morbidity in asthma.
    J Allergy Clin Immunol Pract 2018 Apr 20. Epub 2018 Apr 20.
    Centre for Experimental Medicine, Queen's University of Belfast, N. Ireland. Electronic address:
    Background: Treatment of severe asthma may include high dose systemic-corticosteroid therapy which is associated with substantial comorbidity. There is evidence to suggest that this burden is not evenly distributed across age, gender and corticosteroid exposure levels.

    Objective: Examine the associations between age, gender, comorbidity, and patterns of healthcare cost across groups differentiated by corticosteroid exposure. Read More

    Effects of exercise on brown and beige adipocytes.
    Biochim Biophys Acta 2018 Apr 20. Epub 2018 Apr 20.
    Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address:
    Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adipose tissue (WAT), and have indicated marked adaptations to each tissue with exercise. Studies investigating the effects of exercise on BAT have produced conflicting results, with some showing an increase in the thermogenic activity of BAT and some demonstrating a decrease in the thermogenic activity of BAT. Read More

    Adult Chiari I Malformations: An Analysis of Surgical Risk Factors and Complications using an International Database.
    World Neurosurg 2018 Apr 20. Epub 2018 Apr 20.
    Background: Chiari I malformations are common in adults, and a frequent procedure in neurosurgical practice. Despite a number of studies, to date there is no consensus about the indications or surgical technique for this common condition. Growing emphasis on value-based care has emphasized reduction of readmissions and reoperations, and is particularly relevant in Chiari, which has traditionally been associated with a high complication rate. Read More

    Fetuin B Links Vitamin D deficiency and Pediatric Obesity: Direct Negative Regulation by Vitamin D.
    J Steroid Biochem Mol Biol 2018 Apr 20. Epub 2018 Apr 20.
    Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy; Division of Pediatrics, Università del Piemonte Orientale, Novara, Italy.
    Vitamin D (VD) deficiency (VDD) correlates to obesity, with VD a recognized mediator of metabolic diseases. From a previous proteomic study identifying adiponectin as a link between VDD and pediatric obesity, herein we analysed another protein (SSP2301) increased with VDD. A focused 2D-electrophoretic analysis identified 4 corresponding plasma proteins, with one predicted to be fetuin B (FETUB). Read More

    The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics.
    Exp Neurol 2018 Apr 20. Epub 2018 Apr 20.
    Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, 10117 Berlin, Germany; Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsmedizin Rostock, 18147 Rostock, Germany.
    Evidence for a critical pathophysiological role of aberrant cytoskeletal dynamics is being uncovered in a growing number of neuropsychiatric syndromes. A sedentary lifestyle as well as overt psychopathology is prevalent in patients with the metabolic syndrome. Using mice deficient in gelsolin (Gsn), a crucial actin-severing protein, we here investigated reduced actin turnover as a potential common driver of metabolic disturbances, sedentary behavior, and an anxious/depressive phenotype. Read More

    STAT3 activation by IL-6 from adipose-derived stem cells promotes endometrial carcinoma proliferation and metastasis.
    Biochem Biophys Res Commun 2018 Apr 20. Epub 2018 Apr 20.
    Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:
    Endometrial cancer is the most common gynaecological cancer, and its incidence is increasing. Obesity is a well-recognized risk factor for endometrial cancer, and the mechanisms by which adipose tissue influences tumour development remain controversial. In this study, we examined the high IL-6 level in the ADSCs supernatant following treatment of endometrial cancer cell CM. Read More

    ER stress attenuation by Aloe-derived polysaccharides in the protection of pancreatic β-cells from free fatty acid-induced lipotoxicity.
    Biochem Biophys Res Commun 2018 Apr 20. Epub 2018 Apr 20.
    Department of Life Sciences, Korea University, Seoul, Republic of Korea. Electronic address:
    Insulin resistance, a pathophysiology of type 2 diabetes, is associated with obesity. Lipotoxicity in obesity leads to the dysfunction and death of pancreatic β-cells and inadequate insulin production, thereby aggravating type 2 diabetes. The present study was conducted to determine the effect of Aloe vera polysaccharides (APs) as an anti-hyperglycemic agent and their mechanisms of action. Read More

    The efficacy of selected bariatric surgery methods on lipid and glucose metabolism: a retrospective 12-month study.
    Cent Eur J Public Health 2018 Mar;26(1):49-53
    Faculty of Informatics and Management, University of Hradec Králové, Hradec Králové, Czech Republic.
    Objective: Approximately 25% of the Czech population is currently obese. Obesity rates are expected to increase in the future. Obesity not only raises the risk of health complications for individuals, but increasing rates also represent a significant and steadily growing economic burden for healthcare systems and society as a whole. Read More

    Elevated blood pressure and its predictors among secondary school students in Sarawak: a cross-sectional study.
    Cent Eur J Public Health 2018 03;26(1):16-21
    Department of Community Medicine and Public Health, Faculty of Medicine and Health Sciences, University of Malaysia, Sarawak, Malaysia.
    Objectives: Hypertension is a health issue affecting adolescents. Accumulating evidence affirms that elevated blood pressure begins in childhood and tracks into adulthood. This cross-sectional study was conducted to determine the prevalence of elevated blood pressure and its predictors among secondary school students in Sarawak, Malaysia. Read More

    Liver Disease in a Residential Cohort with Elevated Polychlorinated Biphenyl Exposures.
    Toxicol Sci 2018 Apr 19. Epub 2018 Apr 19.
    Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
    Endocrine and metabolism disrupting chemicals (EDCs/MDCs) have been associated with environmental liver diseases including toxicant-associated steatohepatitis (TASH). TASH has previously been characterized by hepatocellular necrosis, disrupted intermediary metabolism, and liver inflammation. Polychlorinated biphenyls (PCBs) are environmental EDCs/MDCs associated with the genesis and progression of steatohepatitis in animal models and human liver injury in epidemiology studies. Read More

    Outdoor time and dietary patterns in children around the world.
    J Public Health (Oxf) 2018 Apr 19. Epub 2018 Apr 19.
    University of Ottawa Heart Institute, Ottawa, Canada K1Y 4W7.
    Background: Whether outdoor time is linked to dietary patterns of children has yet to be empirically tested. The objective of this study was to examine the association between outdoor time and dietary patterns of children from 12 countries around the world.

    Methods: This multinational, cross-sectional study included 6229 children 9-11 years of age. Read More

    Patterns of SES health disparities among older adults in three upper middle- and two high-income countries.
    J Gerontol B Psychol Sci Soc Sci 2018 Apr 19. Epub 2018 Apr 19.
    Universidad Javeriana, Bogotá, Colombia.
    Objectives: To examine the socioeconomic status (SES) health gradient for obesity, diabetes, and hypertension within a diverse group of health outcomes and behaviors among older adults (60+) in upper middle-income countries benchmarked with high-income countries.

    Method : We used data from three upper middle-income settings (Colombia-SABE-Bogotá, Mexico-SAGE, and South Africa-SAGE) and two high-income countries (England-ELSA and US-HRS) to estimate logistic regression models using age, gender, and education to predict health and health behaviors.

    Results: The sharpest gradients appear in middle-income settings but follow expected patterns found in high-income countries for poor self-reported health, functionality, cognitive impairment, and depression. Read More

    ACOG Committee Opinion No. 736: Optimizing Postpartum Care.
    • Authors:
    Obstet Gynecol 2018 May;131(5):e140-e150
    The weeks following birth are a critical period for a woman and her infant, setting the stage for long-term health and well-being. To optimize the health of women and infants, postpartum care should become an ongoing process, rather than a single encounter, with services and support tailored to each woman's individual needs. It is recommended that all women have contact with their obstetrician-gynecologists or other obstetric care providers within the first 3 weeks postpartum. Read More

    ACOG Committee Opinion No. 734: The Role of Transvaginal Ultrasonography in Evaluating the Endometrium of Women With Postmenopausal Bleeding.
    • Authors:
    Obstet Gynecol 2018 May;131(5):e124-e129
    Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding. Read More

    ACOG Committee Opinion No. 736 Summary: Optimizing Postpartum Care.
    • Authors:
    Obstet Gynecol 2018 May;131(5):949-951
    The weeks following birth are a critical period for a woman and her infant, setting the stage for long-term health and well-being. To optimize the health of women and infants, postpartum care should become an ongoing process, rather than a single encounter, with services and support tailored to each woman's individual needs. It is recommended that all women have contact with their obstetrician-gynecologists or other obstetric care providers within the first 3 weeks postpartum. Read More

    ACOG Committee Opinion No. 734 Summary: The Role of Transvaginal Ultrasonography in Evaluating the Endometrium of Women With Postmenopausal Bleeding.
    • Authors:
    Obstet Gynecol 2018 May;131(5):945-946
    Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding. Read More

    Obesity Impacts Swelling of Ankle and Foot Joints in Early Rheumatoid Arthritis Patients.
    J Clin Rheumatol 2018 Apr 16. Epub 2018 Apr 16.
    Objective: The evaluation of disease activity in obese rheumatoid arthritis (RA) patients presents challenges particularly in the clinical assessment of swollen joints. This study examines the effect of obesity on the American College of Rheumatology (ACR) core set measures used in assessing RA disease activity with specific focus on the swollen joint count (SJC).

    Methods: We examined a cross-sectional cohort of 323 early seropositive RA patients (symptom duration ≤15 months). Read More

    The effect of obesity on long-term survival and health-related quality of life after coronary artery bypass grafting: a 12-year follow-up.
    Coron Artery Dis 2018 Apr 20. Epub 2018 Apr 20.
    Department of Cardiothoracic Surgery, Heart Center, Tampere University Hospital.
    Objective: The proportion of obese patients undergoing coronary artery bypass graft (CABG) surgery is increasing. In this study, our main objective was to assess the effect of obesity on long-term mortality and changes in quality of life (QoL) after GABG.

    Materials And Methods: Data of 508 patients who underwent isolated GABG were prospectively collected. Read More

    Clinical Obesity Services in Public Hospitals in Australia: a position statement based on expert consensus.
    Clin Obes 2018 Apr 23. Epub 2018 Apr 23.
    Baker Heart and Diabetes Institute, Melbourne, Australia.
    We aimed to describe the current state of specialist obesity services for adults with clinically severe obesity in public hospitals in Australia, and to analyse the gap in resources based on expert consensus. We conducted two surveys to collect information about current and required specialist obesity services and resources using open-ended questionnaires. Organizational level data were sought from clinician expert representatives of specialist obesity services across Australia in 2017. Read More

    Exposure to occupational noise and periodontitis in Korean workers.
    J Periodontol 2018 Apr;89(4):431-439
    Department of Preventive and Social Dentistry, Seoul National University School of Dentistry, Seoul, Korea.
    Background: Chronic exposure to occupational noise is reported to cause a wide range of health problems. But, there are no reports on studies investigating the association between noise exposure and periodontitis. The purpose of this study was to examine the relationship between occupational noise exposure and periodontitis in a nationally representative sample of Korean workers. Read More

    Bone functional adaptation does not erase neutral evolutionary information.
    Am J Phys Anthropol 2018 Apr 23. Epub 2018 Apr 23.
    Department of Anthropology, State University of New York at Oneonta, Oneonta, New York.
    Objectives: To investigate whether diaphyseal and craniofacial variation similarly reflect neutral genetic variation among modern European and South Africans.

    Materials And Methods: Diaphyseal and craniofacial data were collected on English, South European, and South African samples. The Relethford-Blangero model was used to compare predicted among-population relationships generated by limb bones relative to those generated by the crania and, further, to test whether adaptive plasticity affected these predicted relationships. Read More

    Proteomic profiling of Ganoderma tsugae ethanol extract-induced adipogenesis displaying browning features.
    FEBS Lett 2018 Apr 23. Epub 2018 Apr 23.
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, 11490, Taiwan, ROC.
    Ganoderma is classified as a top-grade traditional Chinese medicine for promoting human health by regulating "vital energy". Its potency towards metabolism and energy homeostasis, particularly, the metabolic adaptations of adipocytes, needs to be re-evaluated through an evidence-based study. Here, the triterpenoid-rich Ganoderma tsugae ethanol extract (GTEE) is found to contribute towards adipogenesis accompanied with elevated intracellular lipid metabolic flux. Read More

    Maternity Care Update: Preconception Care.
    FP Essent 2018 Apr;467:11-16
    John Peter Smith Hospital Family Medicine Residency, 1500 South Main St 4th Floor OPC, Fort Worth, TX 76104.
    Family physicians are in a unique position to ensure that women receive preconception care. The Centers for Disease Control and Prevention, the American College of Obstetricians and Gynecologists, and the American Academy of Family Physicians recommend preconception care for all women, but particularly for women with comorbid conditions such as obesity, diabetes, and chronic hypertension. Family physicians should ask all women of reproductive age who are at risk of unintended pregnancy if they desire pregnancy within the next year and, based on this answer, provide counseling on contraception or preconception care. Read More

    Hypogonadism and Male Obesity: Focus on Unresolved Questions.
    Clin Endocrinol (Oxf) 2018 Apr 23. Epub 2018 Apr 23.
    Department of Medicine Austin Health, University of Melbourne, Heidelberg, Australia.
    Obesity, increasing in prevalence globally, is the clinical condition most strongly associated with lowered testosterone concentrations in men, and presents as one of the strongest predictors of receiving testosterone treatment. While low circulating total testosterone concentrations in modest obesity primarily reflect reduced concentrations of sex hormone binding globulin, more marked obesity can lead to genuine hypothalamic-pituitary-testicular axis (HPT) suppression. HPT axis suppression is likely mediated via pro-inflammatory cytokine and dysregulated leptin signalling and aggravated by associated comorbidities. Read More

    Development of Subject-Specific Proximal Femur Finite Element Models Of Older Adults with Obesity to Evaluate the Effects of Weight Loss on Bone Strength.
    J Osteoporos Phys Act 2018 8;6(1). Epub 2018 Mar 8.
    Department of Health and Exercise Science, Wake Forest University, USA.
    Study Background: Recommendation of intentional weight loss in older adults remains controversial, due in part to the loss of bone mineral density (BMD) known to accompany weight loss. While finite element (FE) models have been used to assess bone strength, these methods have not been used to study the effects of weight loss. The purpose of this study is to develop subject-specific FE models of the proximal femur and study the effect of intentional weight loss on bone strength. Read More

    Association of epicardial fat thickness with clinical and polysomnographic parameters in non-obese obstructive sleep apnoea patients.
    J Laryngol Otol 2018 Apr 23:1-7. Epub 2018 Apr 23.
    Department of Otorhinolaryngology,School of Medicine,Muğla Sıtkı Koçman University,Muğla,Turkey.
    Objectives: This study aimed to investigate the relationship of epicardial fat thickness with severity of obstructive sleep apnoea, and clinical and polysomnographic parameters, and to determine independent predictors for epicardial fat thickness.

    Methods: A total of 84 patients with a body mass index of less than 30 kg/m2 and suspected sleep-disordered breathing were included in the study. The correlations of epicardial fat thickness with polysomnographic and clinical data, and severity of obstructive sleep apnoea, were investigated. Read More

    "The Weight Is Even Worse Than the Cancer": Exploring Weight Preoccupation in Women Treated for Breast Cancer.
    Qual Health Res 2018 Apr 1:1049732318770403. Epub 2018 Apr 1.
    1 University of Toronto, Toronto, Ontario, Canada.
    Cancer-related changes in body weight are problematic given that excess weight is associated with an increased risk of cancer reoccurrence and mortality. The purpose of this qualitative study was to explore the experiences of weight-concerned women treated for early-stage breast cancer. A purposeful sample of women were selected based on criteria for high weight and body image concerns ( n = 11; M = 65. Read More

    High-Frequency Percussive Ventilation Rescue Therapy in Morbidly Obese Patients Failing Conventional Mechanical Ventilation.
    J Intensive Care Med 2018 Jan 1:885066618769596. Epub 2018 Jan 1.
    4 Department of Cardiothoracic Surgery, Staten Island University Hospital, Staten Island, NY, USA.
    Background: Morbidly obese patients with respiratory failure who do not improve on conventional mechanical ventilation (CMV) often undergo rescue therapy with extracorporeal membrane oxygenation (ECMO). We describe our experience with high-frequency percussive ventilation (HFPV) as a rescue modality.

    Methods: In a retrospective analysis from 2009 to 2016, 12 morbidly obese patients underwent HFPV after failing to wean from CMV. Read More

    Incidence of and Risk Factors for Venous Thromboembolism After Foot and Ankle Surgery.
    Foot Ankle Spec 2018 Apr 1:1938640018769740. Epub 2018 Apr 1.
    Department of Surgery, Division of Orthopaedic Surgery, University of Alabama, Birmingham, Alabama.
    Background: Venous thromboembolism (VTE) is a rare but potentially lethal complication after orthopaedic foot and ankle surgery. The true incidence of VTE after orthopaedic foot and ankle surgery stratified by specific procedure has yet to be examined. The purpose of this study is to report the incidence of and identify risk factors for VTE in a large sample of patients receiving orthopaedic foot and ankle surgery. Read More

    Implications of false-positive results for future cancer screenings.
    Cancer 2018 Apr 23. Epub 2018 Apr 23.
    Medicine Institute, Cleveland Clinic, Cleveland, Ohio.
    Background: False-positive cancer screening results may affect a patient's willingness to obtain future screening.

    Methods: The authors conducted logistic regression analysis of 450,484 person-years of electronic medical records (2006-2015) in 92,405 individuals aged 50 to 75 years. Exposures were false-positive breast, prostate, or colorectal cancer screening test results (repeat breast imaging or negative breast biopsy ≤3 months after screening mammography, repeat prostate-specific antigen [PSA] test ≤3 months after PSA test result ≥4. Read More

    The role of pericardial adipose tissue in the heart of obese minipigs.
    Eur J Clin Invest 2018 Apr 23:e12942. Epub 2018 Apr 23.
    Department of Animal Science and Technology, National Taiwan University, No. 50, Lane 155, Sec 3, Keelung Rd, Taipei, 10672, Taiwan.
    Background: Pericardial adipose tissue (PAT) volume is highly associated with the presence and severity of cardiometabolic diseases, but the underlying mechanism is unknown. We previously demonstrated that a high-fat diet (HFD) induced metabolic dysregulation, cardiac fibrosis, and accumulation of more PAT in minipigs. This study used our obese minipig model to investigate the characteristics of PAT and omental visceral fat (VAT) induced by a HFD, and the potential link between PAT and HFD-related myocardial fibrosis. Read More

    Upper Body Fat Predicts Metabolic Syndrome Similarly in Men and Women.
    Eur J Clin Invest 2018 Apr 23:e12941. Epub 2018 Apr 23.
    Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9052.
    The metabolic syndrome is a constellation of risk factors including dyslipidemia, dysglycemia, hypertension, a pro-inflammatory state, and a prothrombotic state. All of these factors are accentuated by obesity. However, obesity can be defined by body mass index (BMI), percent body fat, or by body fat distribution. Read More

    [Risk factors for anastomotic leakage after rectal cancer surgery].
    Zhonghua Wei Chang Wai Ke Za Zhi 2018 Apirl 25;21(4):384-387
    Department of Gastrointestinal surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technologe, Wuhan 430022, China.
    Anastomotic leakage is one of the common complications after rectal cancer surgery. Advances in the field of rectal surgery, such as introduction of total mesorectal excision, double-stapling reconstruction techniques, and minimally invasive surgery have improved oncologic outcomes and resulted in more favorable functional results, with a greater proportion of patients undergoing sphincter-preserving surgeries. Despite technical improvements, the incidence of anastomotic leakage has not decreased significantly. Read More

    [Risk factors of anastomotic leakage in the procedures of trans-abdominal and transanal total mesorectal excision for rectal cancer].
    Zhonghua Wei Chang Wai Ke Za Zhi 2018 Apirl 25;21(4):378-383
    Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, and National Clinical Research Center for Digestive Diseases, Beijing 100050, China.
    Anastomotic leakage is one of the most serious complications following traditional trans-abdominal total mesorectal excision of rectal cancer. Anastomotic leakage not only affects the postoperative recovery of patients, but also affects their long-term survival. Transanal total mesorectal excision(taTME) is a new surgical procedure developed in recent years. Read More

    Resveratrol reverses the adverse effects of a diet-induced obese murine model on oocyte quality and zona pellucida softening.
    Food Funct 2018 Apr 23. Epub 2018 Apr 23.
    State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China.
    Reproductive dysfunction associated with obesity is increasing among women of reproductive age, including infertility and increasing risk of miscarriage. In females, reproductive disorders are linked to declining quality of oocytes. Using a model of diet-induced obesity, we have investigated the possible effects of obesity on oocyte quality, including metabolism, lipid accumulation, ROS levels, meiosis and changes in spindle structure in Metaphase II. Read More

    Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs.
    J Diabetes Res 2018 25;2018:6823193. Epub 2018 Feb 25.
    Department of Clinical Medicine, Aarhus University and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
    Background: Obesity and metabolic syndrome (MetS) are major risk factors for atherosclerotic diseases; however, a causal link remains elusive. Animal models resembling human MetS and its complications, while important, are scarce. We aimed at developing a porcine model of human MetS. Read More

    Obesity and Overweight Among Brazilian Early Adolescents: Variability Across Region, Socioeconomic Status, and Gender.
    Front Pediatr 2018 6;6:81. Epub 2018 Apr 6.
    School of Physical Education and Physical Therapy, Federal University of Amazonas, Manaus, Amazonas, Brazil.
    Introduction: As with most emerging nations, Brazil lacks up-to-date data on the prevalence of obesity and overweight among its children. Of particular concern is the lack of data on children in early adolescence, considered by many to be the crucial stage for weight-related healthcare.

    Objective: To assess regional, socioeconomic, and gender differences in the prevalence of obesity and overweight among Brazilian early adolescents. Read More

    Kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis.
    PeerJ 2018 17;6:e4542. Epub 2018 Apr 17.
    State Key Laboratory of Animal Nutrition & Key Laboratory of Farm Animal Genetic Resource and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, Beijing, China.
    Background: Type 2 diabetes is characterized by insulin resistance accompanied by defective insulin secretion. Transgenic mouse models play an important role in medical research. However, single transgenic mouse models may not mimic the complex phenotypes of most cases of type 2 diabetes. Read More

    Physical training interventions for children and teenagers affected by acute lymphoblastic leukemia and related treatment impairments.
    Oncotarget 2018 Mar 30;9(24):17199-17209. Epub 2018 Mar 30.
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
    A decreased physical fitness has been reported in patients and survivors of acute lymphoblastic leukemia (ALL). This is influenced by the negative effects of the disease and by the treatments of childhood cancer. In the past, children were advised to recover in bed, and to take as much relax as possible. Read More

    Age at menarche and risks of gestational diabetes mellitus: a meta-analysis of prospective studies.
    Oncotarget 2018 Mar 23;9(24):17133-17140. Epub 2017 Dec 23.
    School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
    Background: Accumulating evidence suggests that early menarche is associated with adult obesity, which in turn may increase the risk of insulin resistance and hyperglycemia. However, the relation of menarcheal age with gestational diabetes mellitus (GDM) remains inconsistent across studies. The objective of this meta-analysis was to evaluate the association between age at menarche and GDM risk. Read More

    Chemerin induces endothelial cell inflammation: activation of nuclear factor-kappa beta and monocyte-endothelial adhesion.
    Oncotarget 2018 Mar 30;9(24):16678-16690. Epub 2018 Mar 30.
    Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK.
    Chemerin, a chemoattractant protein, acts a G-protein coupled chemokine receptor, Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory states such as obesity and type 2 diabetes mellitus (T2DM). Obesity and T2DM patients are at high risk of developing cardiovascular disorders such as atherosclerosis. We have reported that chemerin induces human endothelial cell angiogenesis and since dysregulated angiogenesis and endothelial dysfunction are hallmarks of vascular disease; we sought to determine the effects of chemerin on monocyte-endothelial adhesion, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a critical pro-inflammatory transcription factor. Read More

    Cardiovascular Disease in Japanese Patients with Type 2 Diabetes Mellitus.
    Ann Vasc Dis 2018 Mar;11(1):2-14
    Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Niigata, Japan.
    Individuals with diabetes have a two- to four-fold increased risk of coronary artery disease (CAD) and higher mortality rates than those without diabetes. Because not only microvascular but also macrovascular disease in patients with diabetes are known to predispose patients to a lower quality of life as well as lead to higher mortality rates, identifying and managing risk factors of CAD is of clinical relevance in diabetes care. A number of antihyperglycemic drugs are currently approved for the treatment of hyperglycemia in patients with type 2 diabetes mellitus (T2DM), with several new drugs having been developed during the last decade. Read More

    Effects of 4-Week Intervention with Hance Extract on Immune Function Biomarkers in Healthy Adults: A Randomized Controlled Trial.
    Evid Based Complement Alternat Med 2018 25;2018:5690816. Epub 2018 Feb 25.
    Bio-Port Korea INC, Marine Bio-Industry Development Center, Busan 46048, Republic of Korea.
    extract has been shown to have immune-related effects in animals, but no studies have yet been performed in humans. This randomized, double-blind, placebo-controlled trial was conducted to determine the effect of short-term administration of Hance extract (UME) on immune function biomarkers and its safety in human subjects. Fifty-eight subjects were randomly assigned to a UME group or a placebo group. Read More

    Deciphering Possible Association of Risk Factors for Dental Caries in Pakistani Population.
    Int J Dent 2018 28;2018:2842350. Epub 2018 Feb 28.
    Dow University of Health Sciences, Karachi, Pakistan.
    Obesity is a state of abnormal accumulation of fat in adipose tissues of the body to the level that one's health is adversely compromised. Tripathi et al. state (according to WHO) that obesity is now considered the fifth leading cause of mortality in the world. Read More

    Increased -GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome.
    Front Physiol 2018 6;9:341. Epub 2018 Apr 6.
    Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
    Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with increased body weight and hyperglycemia. The -linked β-N-acetylglucosamine (-GlcNAc) modification of proteins (-GlcNAcylation) is a unique posttranslational process that integrates glucose metabolism with intracellular protein activity. Read More

    NutriNet-Salud México. Prospective study online: 2018-2028. Relationship between nutrition and health and determinants of dietary habits and nutritional status.
    Cir Cir 2018 ;86(1):8-19
    Académie Nationale de Médecine. París, Francia.
    Background: NutriNet-Salud Mexico is a digital health information system, e-epidemiology instrument, online, open and free, to recording and analysis the determinants of dietary habits and nutritional status of the Mexican population, for the prevention of overweight, obesity and noncommunicable diseases for the period 2018-2028.

    Objective: Describe the design, development and implementation of NutriNet-Salud Mexico from the French model NutriNet-Santé France 2008-2018.

    Method: NutriNet-Salud Mexico platform is the basis for the development of health information system for prospective cohort study, scheduled for a period of 10 years (2018-2028), with a dedicated website, and its development will enable to have multiple study populations within an initial set of five self-applicable questionnaires validated in Mexican population. Read More

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