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    Atypical presentation and outcome of cervicogenic headache in patients with cervical degenerative disease: A single-center experience.
    Clin Neurol Neurosurg 2017 May 13;159:62-69. Epub 2017 May 13.
    Department of Neurology and Sleep Medicine, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.
    Objective: Cervicogenic headache affects a significant portion of the entire population. This type of headache especially with atypical presentation is often hard to diagnose and manage since its etiopathophysiology is not been yet well understood. We have investigated the prevalence of cervicogenic headache with atypical presentation and discussed the etiology of it, and the outcome of surgical intervention on this type of headache in patients with cervical degenerative disease. Read More

    The impact of childhood overweight and obesity on healthcare utilisation.
    Econ Hum Biol 2017 May 12;27(Pt A):84-92. Epub 2017 May 12.
    Health Economics and Policy Analysis Centre, J.E. Cairnes School of Business and Economics, NUI Galway, Ireland.
    Rising levels of childhood overweight and obesity represent a major global public health challenge. A number of studies have explored the association between childhood overweight and obesity and healthcare utilisation and costs. This paper adds to the literature by estimating the causal effect of child overweight and obesity status on use of general practitioner (GP) and hospital inpatient stays at two time points using instrumental variable (IV) methods The paper uses data from two waves of the Growing Up in Ireland survey of children when they are 9 and 13 years respectively and uses the biological mother's body mass index (BMI) as an instrument for the child's BMI. Read More

    Baseline Anthropometric and Metabolic Parameters Correlate with Weight Loss in Women 1-Year After Laparoscopic Roux-En-Y Gastric Bypass.
    Obes Surg 2017 May 26. Epub 2017 May 26.
    Digestive Unit, Archet 2 Hospital, University Hospital of Nice, 06202, Nice, France.
    Background: In this study, we explored in a prospective cohort of morbidly obese women undergoing laparoscopic Roux-en-Y gastric bypass (LRYGP) correlations between baseline anthropometrics, metabolic parameters, resting energy expenditure (REE), body composition, and 1-year % excess body mass index loss (%EBMIL). We also investigated risk factors for insufficient %EBMIL.

    Methods: One hundred three consecutive women were prospectively evaluated at baseline (age 40. Read More

    What Are the Real Procedural Costs of Bariatric Surgery? A Systematic Literature Review of Published Cost Analyses.
    Obes Surg 2017 May 26. Epub 2017 May 26.
    Bristol Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2PS, UK.
    This review aims to evaluate the current literature on the procedural costs of bariatric surgery for the treatment of severe obesity. Using a published framework for the conduct of micro-costing studies for surgical interventions, existing cost estimates from the literature are assessed for their accuracy, reliability and comprehensiveness based on their consideration of seven 'important' cost components. MEDLINE, PubMed, key journals and reference lists of included studies were searched up to January 2017. Read More

    Association of poverty and social exclusion with body mass index among Special Olympics athletes in Europe.
    Int J Public Health 2017 May 26. Epub 2017 May 26.
    Physical Education Department, State University of New York College at Cortland, Cortland, USA.
    Objectives: To examine the association of a risk of poverty and social exclusion (AROPE), age, and gender with the body mass index (BMI) status of European Special Olympics athletes.

    Methods: BMI records were available for 1905 children and youth and 5517 adults from the Special Olympics International (SOI) Health Promotion database. AROPE was extracted from EU Eurostat statistics. Read More

    Health Policy Responsiveness: Lessons Learned from Maryland and Prince George's County.
    J Racial Ethn Health Disparities 2017 May 27. Epub 2017 May 27.
    Health Policy Research Consortium, CTIS Inc., Greenbelt, MD, USA.
    Effective, timely, and intentional policy efforts can significantly impact and improve the public's health and reduce racial and ethnic health disparities across the nation. Creating and implementing responsive policies at the state and county level is essential to supporting community efforts to improve health behaviors and health outcomes, particularly for communities of color who bear the brunt of disease risk and negative health outcomes. Using policy examples from the State of Maryland and Prince George's County, the largest and wealthiest predominately African-American county in the USA, this case study highlights the importance of state and county policy action when presented with opportunities to affect long-lasting, positive change. Read More

    Cinnamon induces browning in subcutaneous adipocytes.
    Sci Rep 2017 May 26;7(1):2447. Epub 2017 May 26.
    Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
    Browning is the process of increasing the number of brite cells, which helps to increase energy expenditure and reduce obesity. Consumption of natural and non-toxic herbal extracts that possess the browning effect is an attractive anti-obesity strategy. In this study, we examined the browning effect of cinnamon extract. Read More

    Non-alcoholic fatty liver disease-a chronic disease of the 21(st) century.
    J Biomed Res 2017 May 26. Epub 2017 May 26.
    Cancer Research Program, Block-E, The Research Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal QC H4A 3J1, Canada.
    Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of metabolic states ranging from simple steatosis to inflammation with associated fibrosis to cirrhosis. Though accumulation of hepatic fat is not associated with a significant increase in mortality rates, hepatic inflammation is, as this augments the risk of terminal liver disease, i.e. Read More

    AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation.
    J Alzheimers Dis 2017 May 25. Epub 2017 May 25.
    Chemical Diversity Research Institute, Khimki, Moscow Region, Russian Federation.
    Discovery of 5-HT6 receptor subtype and its exclusive localization within the central nervous system led to extensive investigations of its role in Alzheimer's disease, schizophrenia, and obesity. In the present study, we present preclinical evaluation of a novel highly-potent and highly-selective 5-HT6R antagonist, AVN-492. The affinity of AVN-492 to bind to 5-HT6R (Ki = 91 pM) was more than three orders of magnitude higher than that to bind to the only other target, 5-HT2BR, (Ki = 170 nM). Read More

    Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity.
    Diabetes 2017 May 26. Epub 2017 May 26.
    Department of Obstetrics, Gynecology & Reproductive Sciences,
    The Lin28a/Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation. However, its central function remains unclear. Here we found that Lin28a is highly expressed in the hypothalamus compared to peripheral tissues. Read More

    Chest pain and shortness of breath in cardiovascular disease: a prospective cohort study in UK primary care.
    BMJ Open 2017 May 25;7(5):e015857. Epub 2017 May 25.
    Research Institute for Primary Care and Health Sciences, Keele University, Staffordshire, UK.
    Objective: To determine characteristics associated with monthly chest pain and shortness of breath (SoB) during activity in cardiovascular disease (CVD) and trajectories of these symptoms over 10 months.

    Study Design And Setting: Baseline questionnaire was sent to patients aged ≥40 years from 10 UK general practices. Responders were sent monthly questionnaires for 10 months. Read More

    Statistical Methods for Latent Class Quantitative Trait Loci Mapping.
    Genetics 2017 May 26. Epub 2017 May 26.
    University of Wisconsin, Madison
    Identifying the genetic basis of complex traits is an important problem with the potential to impact a broad range of biological endeavors. A number of effective statistical methods are available for quantitative trait loci (QTL) mapping that allow for the efficient identification of multiple, potentially interacting, loci under a variety of experimental conditions. Although proven useful in hundreds of studies, the majority of these methods assume a single model common to each subject and consequently sacrifice power and accuracy when genetically distinct subclasses exist. Read More

    Associations Between Maternal Depressive Symptoms and Nonresponsive Feeding Styles and Practices in Mothers of Young Children: A Systematic Review.
    JMIR Public Health Surveill 2017 May 26;3(2):e29. Epub 2017 May 26.
    Exercise and Health Sciences, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, United States.
    Background: Childhood obesity is a significant global public health problem due to increasing rates worldwide. Growing evidence suggests that nonresponsive parental feeding styles and practices are important influences on children's eating behaviors and weight status, especially during early childhood. Therefore, understanding parental factors that may influence nonresponsive parental feeding styles and practices is significant for the development of interventions to prevent childhood obesity. Read More

    Overweight in elderly people induces impaired autophagy in skeletal muscle.
    Free Radic Biol Med 2017 May 23. Epub 2017 May 23.
    Department of Cell Biology and Morphology, Faculty of Medicine, University of Oviedo, Av. Julián Clavería s/n, 33006, Oviedo, Asturias, Spain. Electronic address:
    Sarcopenia is the gradual loss of skeletal muscle mass, strength and quality associated with aging. Changes in body composition, especially in skeletal muscle and fat mass are crucial steps in the development of chronic diseases. We studied the effect of overweight on skeletal muscle tissue in elderly people without reaching obesity to prevent this extreme situation. Read More

    Gestational Weight Gain.
    Am J Obstet Gynecol 2017 May 23. Epub 2017 May 23.
    Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
    Prenatal care providers are advised to evaluate maternal weight at each regularly scheduled prenatal visit, monitor progress toward meeting weight gain goals, and provide individualized counseling if significant deviations from a woman's goals occur. Today, nearly 50% of women exceed their weight gain goals with overweight and obese women having the highest prevalence of excessive weight gain. Risks of inadequate weight gain include low birth weight and failure to initiate breastfeeding whereas the risks of excessive weight gain include cesarean deliveries and post-partum weight retention for the mother and large for gestational age infants, macrosomia, and childhood overweight or obesity for the offspring. Read More

    Fatty Liver and FGF21 Physiology.
    Exp Cell Res 2017 May 23. Epub 2017 May 23.
    Professor of Medicine, Harvard Medical School, Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center CLS 7 3 Blackfan Circle Boston, MA 02215. Electronic address:
    Non alcoholic fatty liver disease is linked to obesity and the metabolic syndrome. As rates of obesity rise it has become the major etiology of liver dysfunction. Despite intense study the molecular mechanisms contributing to the onset of fatty liver remain debatable. Read More

    Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial.
    Sleep Med 2017 Jan 12. Epub 2017 Jan 12.
    Vaasa Central Hospital, Department of Surgery, Vaasa, Finland; University of Turku, Turku, Finland. Electronic address:
    Background: Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder, particularly in bariatric patients. It is known to be tightly linked with metabolic abnormalities and cardiovascular morbidity. Obesity is the most noteworthy individual risk factor for OSA. Read More

    Prevalence of abdominal obesity and its association with cardio metabolic risk factors among older adults in Ecuador.
    Diabetes Metab Syndr 2017 May 15. Epub 2017 May 15.
    Universidad Católica de Santiago de Guayaquil, Ave. Carlos julio Arosemena, Guayaquil, Ecuador.
    Aims: To describe the prevalence of abdominal obesity and its association with cardio metabolic risk factors among older adults in Ecuador.

    Materials And Methods: The present study used data from the National Survey of Health, Wellbeing, and Aging survey to examine the prevalence of abdominal obesity according to certain demographic, behavioral, and health characteristics of the participants. Logistic regression models adjusted for potential confounders were used to evaluate the association of abdominal obesity with cardio metabolic risk factors. Read More

    Body Mass is Positively Associated with Neural Response to Sweet Taste, But Not Alcohol, Among Drinkers.
    Behav Brain Res 2017 May 23. Epub 2017 May 23.
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA. Electronic address:
    Obesity is a large and growing public health concern, presenting enormous economic and health costs to individuals and society. A burgeoning literature demonstrates that overweight and obese individuals display different neural processing of rewarding stimuli, including caloric substances, as compared to healthy weight individuals. However, much extant research on the neurobiology of obesity has focused on addiction models, without highlighting potentially separable neural underpinnings of caloric intake versus substance use. Read More

    Maternal Obesity, 25-Hydroxy Vitamin D Concentration, and Bone Density in Breastfeeding Dyads.
    J Pediatr 2017 May 23. Epub 2017 May 23.
    Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC.
    Objective: To examine the association between maternal body mass index (BMI) and serum 25-hydroxy vitamin D [25(OH)D] concentration and bone density in mother-infant pairs.

    Study Design: The study was a secondary analysis of 234 exclusively breastfeeding dyads who were recruited in the first postpartum month for a randomized controlled trial of maternal vs infant vitamin D supplementation. Mean 25(OH)D concentrations and bone mineral density (BMD) were compared by BMI group. Read More

    Taste sensitivity to sucrose is lower in outbred Sprague-Dawley phenotypic obesity prone rats than obesity resistant rats.
    Biochem Biophys Res Commun 2017 May 23. Epub 2017 May 23.
    Research Center of Stomatology College, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Department of Physiology and Pathophysiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. Electronic address:
    The purpose of the present study was to better understand the role of sweet taste perception in dietary behavior and body weight in outbred Sprague-Dawley phenotypic obesity prone and obesity resistant rats by measuring sucrose taste sensitivity using a conditioned taste aversion paradigm. Rats were given a high fat diet for 2 weeks and were assigned as obesity-prone (P, upper tertile) or obesity-resistant (R, lower tertile) based on weight gain. Each group were then given either chow (C, 10% fat) or the high fat diet (F, 46% fat) for the remainder of the experiment (∼18 weeks) such that there were four groups - obesity prone on chow (C-P), obesity prone on high fat (H-P), obesity resistant on chow (C-R), obesity resistant on high fat (H-R). Read More

    The Kv1.3 channel blocker Vm24 enhances muscle glucose transporter 4 mobilization but does not reduce body-weight gain in diet-induced obese male rats.
    Life Sci 2017 May 23. Epub 2017 May 23.
    Departamento de Fisiología Molecular y Biología del Desarrollo, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico. Electronic address:
    Aims: Voltage-gated potassium channels 1.3 (Kv1.3) can be targeted to reduce diet-induced obesity and insulin resistance in mice. Read More

    Changes in Waist Circumference and Abdominal Obesity among Chinese Adults over a Ten-year Period.
    Biomed Environ Sci 2017 May;30(5):315-322
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
    Objective: The aim of this study was to describe changes in waist circumference (WC) and prevalence of abdominal obesity over a period of 10 years among Chinese adults in different socio-economic status (SES).

    Methods: Data derived from the China Nutrition and Health Surveillance during 2002 and 2010-2012. We calculated the mean WC and the prevalence of abdominal obesity by gender, place of residence, SES indicators (education, income, and marital status), and body mass index (BMI) categoriesand used pooled t-tests to assess the differences between the two time periods. Read More

    INTER-ACT: prevention of pregnancy complications through an e-health driven interpregnancy lifestyle intervention - study protocol of a multicentre randomised controlled trial.
    BMC Pregnancy Childbirth 2017 May 26;17(1):154. Epub 2017 May 26.
    Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
    Background: Excessive maternal pre-pregnancy and gestational weight gain are related to pregnancy- and birth outcomes. The interpregnancy time window offers a unique opportunity to intervene in order to acquire a healthy lifestyle before the start of a new pregnancy.

    Methods: INTER-ACT is an e-health driven multicentre randomised controlled intervention trial targeting women at high risk of pregnancy- and birth related complications. Read More

    LL-37-induced human mast cell activation through G protein-coupled receptor MrgX2.
    Int Immunopharmacol 2017 May 23;49:6-12. Epub 2017 May 23.
    Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. Electronic address:
    Human LL-37 is an important class of cationic antimicrobial peptide (CAP) that is known to stimulate mast cell activation. While many studies have been conducted on LL-37, to date little is known about the functional receptors for LL-37-induced human mast cell activation, in particular in terms of the release of de novo synthesized mediators. Thus, the aim of the present study is to identify the functional receptors for LL-37-induced human mast cell activation in terms of the degranulation and release of de novo synthesized mediators and investigate the downstream signalling pathways involved in mast cell activation. Read More

    Dietary salecan reverts partially the metabolic gene expressions and NMR-based metabolomic profiles from high-fat-diet-induced obese rats.
    J Nutr Biochem 2017 May 5;47:53-62. Epub 2017 May 5.
    Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China. Electronic address:
    Previous studies suggest that dietary salecan (a water-soluble β-glucan) effectively reduces high-fat-diet-induced adiposity through disturbing bile-acid-promoted emulsification in mice. However, the effects of salecan on metabolic genes and metabolites involved in lipid accumulation are mostly unknown. Here, we confirmed that dietary 3% and 6% salecan for 4 weeks markedly decreased fat accumulation in liver and adipose tissue in high-fat-diet rats, displaying a decrease in mRNA levels of SREBP1-C, FAS, SCD1 and ACC1 involved in de novo lipogenesis and a reduction of levels of GPAT1, DGAT1 and DGAT2 related to triglyceride synthesis. Read More

    The molecular mechanisms of obesity paradox.
    Cardiovasc Res 2017 May 26. Epub 2017 May 26.
    1st Cardiology Department, Hippokration Hospital, Athens Medical School.
    Clinical observations suggest a complex relationship between human obesity and cardiovascular disease. Whilst abdominal (visceral) adiposity leads to deleterious metabolic disturbances, subcutaneous fat accumulation has a benign effect on cardiometabolic risk. Notably, an accumulating body of evidence paradoxically links increased body mass index with a better prognosis in patients with established cardiovascular disease, a finding that has been termed the 'obesity paradox'. Read More

    Food addiction and obesity: unnecessary medicalization of hedonic overeating.
    Nat Rev Endocrinol 2017 May 26. Epub 2017 May 26.
    School of Psychology, Faculty of Medicine &Health, Lifton Place, University of Leeds, Leeds LS2 9JT, West Yorkshire, UK.
    The concept of addiction is loaded with connotations and is often used for its political as much as its medical utility. The scientific case for 'food addiction' as a clinical phenotype currently rests on its association with generic diagnostic criteria for substance-related disorders being applied to everyday foods and eating-related problems. This has fused the concept of obesity with addiction regardless of whether it fits the definition. Read More

    Transcriptome profiling in preadipocytes identifies long noncoding RNAs as Sam68 targets.
    Oncotarget 2017 May 11. Epub 2017 May 11.
    Terry Fox Molecular Oncology Group, Segal Cancer Centre and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Oncology and Medicine, McGill University, Montréal, Québec, Canada.
    The KH-type RNA binding protein Sam68 is required for adipogenesis. We have previously shown that Sam68-deficient mice have a lean phenotype and are protected against dietary-induced obesity due to defects in mTOR and S6K1 alternative splicing. Herein we profiled the transcriptome of Sam68 wild type and deficient 3T3-L1 mouse preadipocytes. Read More

    From rapalogs to anti-aging formula.
    Oncotarget 2017 May 22. Epub 2017 May 22.
    Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
    Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Read More

    Overweight, obesity and height as risk factors for meningioma, glioma, pituitary adenoma and nerve sheath tumor: a large population-based prospective cohort study.
    Acta Oncol 2017 May 26:1-8. Epub 2017 May 26.
    c Institute of Clinical Medicine, Faculty of Medicine , University of Oslo , Oslo , Norway.
    Background: In 2016, the International Agency for Research on Cancer (IARC) has announced that avoiding body fatness (i.e. overweight and obesity) contributes to prevent meningioma occurrence, but considered the available evidence for glioma inadequate. Read More

    Microalgal Oil from Schizochytrium sp. Prevents HFD-Induced Abdominal Fat Accumulation in Mice.
    J Am Coll Nutr 2017 May 26:1-10. Epub 2017 May 26.
    a Institute for Genome Engineered Animal Models of Human Diseases , Dalian Medical University , Dalian , Liaoning , China.
    Objective: Dietary n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA), are proved to be effective in obesity reduction. Microalgal oil (MO) is an important alternative source of n-3 PUFAs that effectively alleviates obesity. The aim of the present study was to explore the anti-obesity effects of microalgal oil from Schizochytrium sp. Read More

    A Physical Education Intervention Effects on Correlates of Physical Activity and Motivation.
    Health Promot Pract 2017 May 1:1524839917707740. Epub 2017 May 1.
    1 Northern Arizona University, Flagstaff, AZ, USA.
    Purpose: The purpose of this study was to measure effects of a modified physical education (PE) unit on leisure time physical activity (LTPA), relative autonomy, and known correlates of LTPA in seventh-grade boys and girls.

    Method: A seventh-grade mountain biking unit was modified to include instructional activities targeting known correlates of PA behavior following principles of Physical Education Dedicated to Physical Activity for Life (PEDAL). A three-group design (intervention, standard PE, no PE) was employed. Read More

    Discovery of a human neuromedin U receptor 1-selective hexapeptide agonist with enhanced serum stability.
    J Med Chem 2017 May 26. Epub 2017 May 26.
    Neuromedin U (NMU), activates two NMU receptors (NMUR1 and NMUR2), and is a useful anti-obesity drug lead. We report discovery of a hexapeptide agonist, 2-thienylacetyl-Trp(1)-Phe(4-F)(2)-Arg(3)-Pro(4)-Arg(5)-Asn(6)-NH2 (4). However, the NMUR1 selectivity and serum stability of this agonist were unsatisfactory. Read More

    Obesity gets on your renal nerves.
    Acta Physiol (Oxf) 2017 May 26. Epub 2017 May 26.
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark.
    In the present issue of Acta Physiologica(1) , Khan et al. in their article "Improvement in baroreflex control of renal sympathetic nerve activity in obese Sprague-Dawley rats following immunosuppression" confirm that obesity-related hypertension involves resetting of the arterial baroreceptor to a state of less sensitivity and relate this mechanistically to inflammation-induced altered renal afferent nerve activity (1) . Pharmocological treatment with the calcineurin phosphatase inhibitor-type immunosuppressant tacrolimus attenuated inflammation, reversed, paradoxically, the hypertension and restored baroreceptor sensitivity similar to the effect of renal denervation. Read More

    Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity.
    J Intern Med 2017 May 26. Epub 2017 May 26.
    Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
    Background: Overconsumption of dietary sugars, fructose in particular, is linked to cardiovascular risk factors such as type 2 diabetes, obesity, dyslipidemia, and non-alcoholic fatty liver disease. However, clinical studies have to date not clarified whether these adverse cardiometabolic effects are induced directly by dietary sugars, or if they are secondary to weight gain.

    Objectives: To assess the effects of fructose (75 g/day), served with their habitual diet over 12 weeks, on liver fat content and other cardiometabolic risk factors in a large cohort (n=71) of abdominally obese men. Read More

    [Physical activity, obesity and self-esteem in chilean schoolchildren].
    Rev Med Chil 2017 Mar;145(3):299-308
    Departamento Nutrición y Bromatología, Universidad de Granada, España.
    Background: Obesity is a worldwide epidemic disease and a problem for the Chilean society.

    Aim: To analyze the relationship between physical condition, body mass index (BMI), level of physical activity and self-esteem. Material ad Methods: Questionnaires to assess self-esteem (Rosemberg scale) and levels of physical activity (Physical Activity Questionnaire for older Children, PAQ-C) were answered by 515 children aged 10. Read More

    [Cardiovascular risk factors among first and third year university students].
    Rev Med Chil 2017 Mar;145(3):299-308
    EPICYN, Centro de Epidemiología Cardiovascular y Nutricional, Universidad de La Frontera, Temuco, Chile.
    Background: College students are in a critical stage in their life style due to the transition between high school and university and they may be prone to develop cardiovascular diseases.

    Aim: To compare the prevalence of cardiovascular risk factors (CVRF) in students from first and third year at the University of La Frontera, Temuco-Chile, according to faculty, gender and socioeconomic status (SES).

    Material And Methods: Cross-sectional study. Read More

    [Evaluation the American College of Cardiology and American Heart Association Predictive score for cardiovascular diseases].
    Rev Med Chil 2017 Mar;145(3):292-298
    Departamento de Matemáticas, Universidad de la Serena, La Serena, Chile.
    Background: Recently, the American College of Cardiology and American Heart Association (ACC/AHA) proposed a new cardiovascular risk (CV) score.

    Aim: To evaluate the new risk score (ACC/AHA 2013) in a Chilean population.

    Material And Methods: Between 2002 and 2014, body mass index (BMI), waist circumference, blood pressure, lipid profile and fasting blood glucose levels were measured and a survey about CV risk factors was responded by 3,284 subjects aged 40 to 79 years (38% females), living in urban Santiago. Read More

    Obesity and kidney disease: hidden consequences of the epidemic.
    Rev Med Chil 2017 Mar;145(3):281-291
    CNR-IFC Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Reggio Calabria, Italy.
    Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for Chronic kidney disease. A high body mass index is one of the strongest risk factors for new-onset Chronic kidney disease. Read More

    Impact of age, sex, socioeconomic status, and physical activity on associated movements and motor speed in preschool children.
    J Clin Exp Neuropsychol 2017 May 26:1-12. Epub 2017 May 26.
    a Child Development Centre , University Children's Hospital Zurich , Zurich , Switzerland.
    Introduction: Young children generally show contralateral associated movements (CAMs) when they are making an effort to perform a unimanual task. CAM and motor speed are two relevant aspects of motor proficiency in young children. These CAMs decrease over age, while motor speed increases. Read More

    Correlation between obesity and prognostic/predictive parameters with emphasis on the importance of lymph node metastases in patients with invasive breast carcinoma.
    Pol J Pathol 2017 ;68(1):33-39
    We aimed to evaluate whether obese women experience more advanced invasive breast carcinoma (IBC) with a higher number of involved lymph nodes, higher range of axillary lymph node ratio (LNR) and presence and size of extracapsular extension as it may have an impact on prognosis and management. 245 patients diagnosed with IBC were divided into normal weight (NW), overweight (OW) and obese (OB) groups. Patients were divided into high range of LNR (LNR over or equal to 0. Read More

    Lack of Association of the Fat Mass and Obesity Associated (FTO) Gene rs9939609 Polymorphism with Breast Cancer Risk: a Systematic Review and Meta-Analysis Based on Case - Control Studies
    Asian Pac J Cancer Prev 2017 04 1;18(4):1031-1037. Epub 2017 Apr 1.
    Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
    Background: Previously published data on any association of the fat mass and obesity-associated (FTO) gene with breast cancer risk remain inconclusive. Therefore, we conducted the present meta-analysis of links between breast cancer and the FTO rs9939609 polymorphism. Methods: We have conducted a systematic review of the English literature by searching PubMed, Google Scholar and ISI Web of Knowledge databases for studies on associations between the FTO rs9939609 polymorphism and breast cancer risk. Read More

    Exercise with weight loss improves adipose tissue and skeletal muscle markers of fatty acid metabolism in postmenopausal women.
    Obesity (Silver Spring) 2017 May 26. Epub 2017 May 26.
    Department of Medicine, Division of Gerontology and Geriatric Medicine at the University of Maryland School of Medicine, Baltimore, Maryland, USA.
    Objective: The effects of 6-month weight loss (WL) versus aerobic exercise training (AEX)+WL on fat and skeletal muscle markers of fatty acid metabolism were determined in normal (NGT) and impaired (IGT) glucose tolerant African-American and Caucasian postmenopausal women with overweight/obesity.

    Methods: Fat (gluteal and abdominal) lipoprotein lipase (LPL), skeletal muscle LPL, acyl-CoA synthase (ACS), ß-hydroxacyl-CoA dehydrogenase, carnitine palmitoyltransferase (CPT-1), and citrate synthase (CS) activities were measured at baseline (n = 104) and before and after WL (n = 34) and AEX+WL (n = 37).

    Results: After controlling for age and race, muscle LPL and CPT-1 were lower in IGT, and the ratios of fat/muscle LPL activity were higher in IGT compared to NGT. Read More

    Non-shivering thermogenesis as a mechanism to facilitate sustainable weight loss.
    Obes Rev 2017 May 25. Epub 2017 May 25.
    Biomedical Research Department, Diabetes and Obesity Research Division, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    Currently, there is a significant percentage of the population who are or will be classified as obese, necessitating novel strategies to facilitate sustainable weight loss. Reductions in basal metabolic rate occur in the face of weight loss and pose formidable barriers to individuals attempting to sustain meaningful weight reductions. Here, we discuss the mechanisms by which non-shivering thermogenesis may provide insight into metabolic pathways that can become druggable targets to facilitate sustainable weight loss. Read More

    Does body image influence the relationship between body weight and breastfeeding maintenance in new mothers?
    Br J Health Psychol 2017 May 26. Epub 2017 May 26.
    Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, UK.
    Objectives: Obese women have lower breastfeeding initiation and maintenance rates than healthy weight women. Research generally focuses on biomedical explanations for this. Psychosocial factors including body image and well-being after childbirth are less well understood as predictors of breastfeeding. Read More

    Rice Bran Metabolome Contains Amino Acids, Vitamins & Cofactors, and Phytochemicals with Medicinal and Nutritional Properties.
    Rice (N Y) 2017 Dec 2;10(1):24. Epub 2017 Jun 2.
    Department of Environmental & Radiological Health Sciences, College of Veterinary Medicine and Biological Sciences, Colorado State University, 1680 Campus Delivery, Fort Collins, CO, 80523, USA.
    Background: Rice bran is a functional food that has shown protection against major chronic diseases (e.g. obesity, diabetes, cardiovascular disease and cancer) in animals and humans, and these health effects have been associated with the presence of bioactive phytochemicals. Read More

    Costs associated with community acquired pneumonia in France.
    Eur J Health Econ 2017 May 25. Epub 2017 May 25.
    ESSEC Business School, Avenue Bernard Hirsch, 95021, Cergy-Pontoise Cedex, France.
    Objectives: Pneumocost is a prospective study that aimed at documenting the costs of the management of patients hospitalized with a pneumococcal pneumonia and the post-discharge costs during a 6-month period in the French context.

    Methods: Billing data were used to document hospital costs. Resource use during the follow-up period was collected through phone interviews at month 1, 3 and 6. Read More

    Incidence and Predictors of Hypoglycemia 1 Year After Laparoscopic Sleeve Gastrectomy.
    Obes Surg 2017 May 25. Epub 2017 May 25.
    Center for the Study and the Integrated Management of Obesity, University Hospital of Padova, Padova, Italy.
    Introduction: Hypoglycemia is a known adverse event following gastric bypass. The incidence of hypoglycemia after laparoscopic sleeve gastrectomy (LSG) is still under investigation. The aim of our study was to verify the presence of oral glucose tolerance test (OGTT)-related hypoglycemia after LSG and to identify any baseline predictors of its occurrence. Read More

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