Exposure to air pollution interacts with obesogenic nutrition to induce tissue-specific response patterns.
- Michal Pardo,
- Yael Kuperman,
- Liron Levin,
- Assaf Rudich,
- Yulia Haim,
- James J Schauer,
- Alon Chen,
- Yinon Rudich
Environ Pollut 2018 Apr 20;239:532-543. Epub 2018 Apr 20.
Department of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel.
Obesity and exposure to particular matter (PM) have become two leading global threats to public health. However, the exact mechanisms and tissue-specificity of their health effects are largely unknown. Here we investigate whether a metabolic challenge (early nutritional obesity) synergistically interacts with an environmental challenge (PM exposure) to alter genes representing key response pathways, in a tissue-specific manner. Read More