3,111 results match your criteria Ob.Gyn. News[Journal]


Cancer Gene Discovery: Past to Present.

Methods Mol Biol 2019 ;1907:1-15

Department of Ob-Gyn & Women's Health, University of Minnesota, Minneapolis, MN, USA.

Cancer is a complex disease that originates from genetic changes leading to multiple phenotypic manifestations that ultimately result in suffering and death from cancer. Attempts have been made to define the phenotypic and genetic "hallmarks" of cancer, but many of these "hallmarks" remain descriptive, while the underlying mechanisms responsible for these hallmarks remain elusive. For decades, cancer researchers have been methodically identifying the molecular mechanisms that result in tumor initiation, growth, metastases, and resistance to therapy. Read More

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January 2019

Gynecologic radiation oncology patients report unmet needs regarding sexual health communication with providers.

J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA.

Purpose: Following radiation therapy (RT), women with gynecologic malignancies report high rates of sexual dysfunction, but little is known regarding sexual health communication between these patients and health-care providers. This study assessed these patients' beliefs/attitudes toward providers' sexual history taking.

Methods: Surveys were administered to women who presented for follow-up care for gynecologic cancers in an academic radiation oncology department. Read More

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December 2018

The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review.

Evid Based Complement Alternat Med 2018 14;2018:2532935. Epub 2018 Nov 14.

OB/GYN Hospital, Fudan University, Shanghai, China.

Purpose: To evaluate the effect of berberine (BBR) on polycystic ovary syndrome (PCOS) patients with insulin resistance (IR).

Methods: PubMed (in English), Medline (in English), Embase (in English), CNKI (in Chinese), WanFang DATA (in Chinese), and VIP (in Chinese) were searched for randomized controlled trials in human beings with the search terms including "polycystic ovary syndrome /PCOS" and "berberine/BBR/Huang liansu (in Chinese)/ Xiao bojian (in Chinese)" till July 2018. Relevant indices were collected and analyzed by Stata 13. Read More

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November 2018

Secondary research uses of residual newborn screening dried bloodspots: a scoping review.

Genet Med 2018 Dec 10. Epub 2018 Dec 10.

School of Medicine, Department of Ob/Gyn and Pediatrics, University of Utah, Salt Lake City, UT, USA.

Purpose: Residual newborn screening dried bloodspots (DBS) are a valuable resource for research but the extent, type, and nature of uses are unknown. The objective of this research was to systematically review the published literature about secondary research uses of residual DBS using a scoping review protocol.

Methods: A total of 654 publications meeting the inclusion criteria with a 94% interrater reliability were identified. Read More

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December 2018

Uterine contractility changes in a perfused swine uterus model induced by local anesthetics procaine, lidocaine, and ropivacaine.

PLoS One 2018 6;13(12):e0206053. Epub 2018 Dec 6.

Department of Gynecological Endocrinology and Fertility Disorders, University of Heidelberg, Heidelberg, Germany.

Background: Local anesthetics (LAs) are increasingly used as therapeutics due to their multiple molecular effects. They may be potential agents also in gynecology and reproductive medicine. The objective of this study was to investigate the contractility response of the perfused swine uterus to different concentrations of the LAs procaine, lidocaine, and ropivacaine. Read More

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December 2018
2 Reads

Initiating patient discussions about oocyte cryopreservation: Attitudes of obstetrics and gynaecology resident physicians.

Reprod Biomed Soc Online 2018 Aug 7;6:72-79. Epub 2018 Nov 7.

Yale University, Fertility Center, New Haven, CT, USA.

This study examined the attitudes of obstetrics and gynaecology (OB/GYN) resident physicians to initiating patient discussions regarding medical and elective oocyte cryopreservation (OC). The study used a cross-sectional online survey of OB/GYN medical residents in the USA, sampled from residency programmes approved by the American Council for Graduate Medical Education. In total, 208 medical residents, distributed evenly between postgraduate years 1-4, participated in the study. Read More

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A Case of Urethral Diverticulum with Surgical Repair Using Cadaveric Pericardial Tissue.

Case Rep Urol 2018 4;2018:6183618. Epub 2018 Nov 4.

West Virginia University, Department of OB/GYN, Morgantown, WV, USA.

A urethral diverticulum is a relatively uncommon finding. The estimated prevalence is approximately 1-5% in the general population. While the definitive treatment is surgical correction, there are limited studies guiding the best approach to repair. Read More

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November 2018
3 Reads

Ovarian reserve in adolescent girls born prematurely.

Horm Mol Biol Clin Investig 2018 Dec 5. Epub 2018 Dec 5.

Regional Children's Clinical Hospital, Kemerovo, Russia.

Background The objective was to estimate ovarian reserve in adolescent girls born prematurely. Materials and methods Two hundred adolescent girls aged 15-16 years who were born prematurely and full term were studied with laboratory, ultrasound and statistical methods. Results Statistically significant differences of the main parameters that characterize ovarian reserve in adolescent girls born prematurely compared to those born full term were specified. Read More

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December 2018
1 Read

NICU infant health severity and family outcomes: a systematic review of assessments and findings in psychosocial research.

J Perinatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Many infants (7-15%) spend time in the neonatal intensive care unit (NICU) and continue to experience medical issues after discharge. Family psychological responses range widely depending on burden of care, access to resources, and parental characteristics. The current systematic review examined how infant health severity is assessed and related to family psychological (e. Read More

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December 2018

Prenatal and postnatal presentation of PRMT7 related syndrome: Expanding the phenotypic manifestations.

Am J Med Genet A 2018 Dec 4. Epub 2018 Dec 4.

Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.

Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyze the transfer of methyl groups from S-adenosyl-l-methionine to nitrogen atoms on arginine residues. Arginine methylation is involved in multiple biological processes, such as signal transduction, mRNA splicing, transcriptional control, DNA repair, and protein translocation. Currently, 10 patients have been described with mutations in PRMT7. Read More

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December 2018
2 Reads

The Musings of Surgeon as Patient.

J Minim Invasive Gynecol 2018 Nov 25. Epub 2018 Nov 25.

U Mass Medical School/Baystate Medical Center, Private Practice Baystate OB/Gyn Group Inc, Springfield, MA, USA. Electronic address:

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November 2018

Trauma-informed care in a patient-centered medical home for adolescent mothers and their children.

Psychol Serv 2018 Nov 26. Epub 2018 Nov 26.

Department of Ob/Gyn, Children's Hospital Colorado, University of Colorado School of Medicine.

Adolescent mothers experience higher rates of trauma and abuse, as well as increased risks for mental health disorders, compared to adolescent girls who are not mothers, making them a particularly vulnerable population and contributing to them feeling less supported by or allied with their medical provider. Women with a history of childhood abuse face increased rates of obstetric complications; their infants are at increased risk for low birthweight, developmental and intellectual delays, and behavioral problems. Trauma-informed care has become widespread in mental health settings; however, this model has not been as commonly applied to other settings, such as patient-centered medical homes (PCMHs). Read More

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November 2018
4 Reads

The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond.

Future Oncol 2018 Nov 26. Epub 2018 Nov 26.

Department of Obstetrics & Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Once unimaginable, fertility management is now a nationally established part of cancer care in institutions, from academic centers to community hospitals to private practices. Over the last two decades, advances in medicine and reproductive science have made it possible for men, women and children to be connected with an oncofertility specialist or offered fertility preservation soon after a cancer diagnosis. The Oncofertility Consortium's National Physicians Cooperative is a large-scale effort to engage physicians across disciplines - oncology, urology, obstetrics and gynecology, reproductive endocrinology, and behavioral health - in clinical and research activities to enable significant progress in providing fertility preservation options to children and adults. Read More

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November 2018
9 Reads

Introduction of Posterior Axilla Sling Traction in Simulated Shoulder Dystocia.

AJP Rep 2018 Oct 18;8(4):e247-e250. Epub 2018 Oct 18.

Division of MFM, Department of OB/GYN, Naval Medical Center Portsmouth, Portsmouth, Virginia.

 Aim of this study was to introduce posterior axilla sling traction (PAST) in delivering providers and nursing staff as an adjunct to the management of shoulder dystocia and evaluate comfort in performing the maneuver.  A presimulation questionnaire had given to all participants. A brief training on how to perform PAST was also given. Read More

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October 2018

Shared Decision-Making to Improve Patient Engagement in Minimally Invasive Hysterectomy.

Surg Technol Int 2018 Nov 23;34. Epub 2018 Nov 23.

Health Economics and Reimbursement, Edwards Lifesciences, Irvine, California.

Shared decision-making (SDM) between the patient and physician is receiving increased attention as a way to improve patient satisfaction and value of care. Having a readily implemented tool available to inform conversation may enable SDM at a high-volume gynecologic surgery practice. Our objective was to evaluate the impact of an SDM tool on patients' decision to have minimally invasive gynecology surgery. Read More

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November 2018
10 Reads

Assessing Maternity Care Providers' Knowledge of the Management of Hepatitis B in Pregnancy.

J Obstet Gynaecol Can 2018 Nov 22. Epub 2018 Nov 22.

Faculty of Medicine, University of British Columbia, Vancouver, BC; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC; Women's Health Research Institute, Vancouver, BC. Electronic address:

Objective: This study sought to evaluate maternity care providers' knowledge of the management of hepatitis B virus (HBV) in pregnancy.

Methods: A total of 71 maternity care providers from obstetrics, family practice, and midwifery who were practicing at a tertiary women's hospital in Canada completed a survey assessing their demographics and knowledge of the management of HBV in pregnancy. Descriptive statistics were used to assess the survey responses. Read More

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November 2018
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Outcome and Associated Findings in Individuals with Pre- and Postnatal Diagnosis of Tetralogy of Fallot (TOF) and Prediction of Early Postnatal Intervention.

Ultraschall Med 2018 Nov 19. Epub 2018 Nov 19.

Department of OB&GYN, Justus-Liebig-University and UKGM, Division of Prenatal Medicine, Giessen, Germany.

Purpose:  The aim of our retrospective evaluation was to compare the outcome of patients with prenatal and postnatal diagnosis of Tetralogy of Fallot (TOF) and to analyze prenatal echocardiographic parameters predicting intervention within 30 days postnatal.

Materials And Methods:  We evaluated 142 patients in our pediatric heart center and prenatal diagnosis center and prenatal practice Praenatal plus in Cologne between 01/08 - 06/16.

Results:  Within the prenatal diagnosis group, 6/74 fetuses (8. Read More

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November 2018
2 Reads

Radical Trachelectomy for Early Stage Cervical Cancer.

Curr Treat Options Oncol 2018 Nov 19;19(12):75. Epub 2018 Nov 19.

Instituto Gyneco-Oncólogico, 252 San Jorge St, San Juan, PR, 00914, USA.

Opinion Statement: In patients with early-stage cervical cancer, radical hysterectomy and pelvic lymphadenectomy is the gold standard. However, this disease commonly affects women of childbearing age; thus an option to spare fertility is ideal. This option came to fruition in the early 90s when the Dargent procedure or radical trachelectomy was first reported. Read More

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November 2018
1 Read

Prenatal diagnosis of brainstem anomalies.

Eur J Paediatr Neurol 2018 Jul 6. Epub 2018 Jul 6.

Fetal Neurology Clinic, Ultrasound in Ob-Gyn Unit, Wolfson Medical Center, Holon, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Pediatric Neurology Unit, Wolfson Medical Center, Holon, Israel.

Prenatal diagnosis of brainstem anomalies is important due to the usually associated neurodevelopmental impairment and genetic implications. The extreme developmental changes that the brainstem and cerebellum undergo during fetal life pose a challenge for the characterization and definition of the different malformations. The present review aims to demonstrate the normal development of the fetal brainstem and to present the main features required for diagnosis of its anomalies according to available data in the medical literature. Read More

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July 2018
1 Read

How accurate are we in urethral mobility assessment? Comparison of subjective and objective assessment.

Ceska Gynekol Fall 2018;83(4):257-262

Objective: The knowledge of the mobility of urethra plays important role in patients with stress urinary incontinence and its assessment is a part of standard urogynecological examination. It has been assumed that increased mobility is associated with higher likelihood of successful treatment. There is arbitrary defined cut-off for hypermobile urethra - descend of more than 15 mm or 30-degree resp. Read More

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November 2018
4 Reads

Opioid prescribing practices and medication use following urogynecological surgery.

Neurourol Urodyn 2018 Nov 15. Epub 2018 Nov 15.

Department of Urology, Montefiore Medical Center, Bronx, New York.

Background: Opioid abuse is a growing epidemic in the United States, with opioid overdose becoming a leading cause of death. There is wide variation in prescription practices for post-operative opioids due to absence of guidelines. The purpose of this study is to examine postoperative opioid prescribing patterns after urogynecologic surgery and determine usage and management of opioid pills by patients. Read More

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November 2018
4 Reads

Learning curve for the ultrasonographic diagnosis of deep endometriosis using a structured off-line training program.

Ultrasound Obstet Gynecol 2018 Nov 13. Epub 2018 Nov 13.

Department of Obstetrics and Gynecology, Clínica Universidad de Navarra, School of Medicine, University of Navarra, Pamplona, Spain.

Objective: The aim of the present study was to assess the learning curves of trainees during a structured off-line/hands-on training program on the diagnosis of deep infiltrating endometriosis (DIE).

Methods: A two-week training program was conducted. One day was devoted to theoretical issues and guided off-line analysis of 10 volumes of three-dimensional (3D) ultrasound. Read More

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November 2018
3 Reads

Health Care Barriers to Provision of Long-Acting Reversible Contraception in Wisconsin.

WMJ 2018 Oct;117(4):149-155

Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin,

Introduction: Long-acting reversible contraceptives (LARC), specifically implants and intrauterine devices (IUD), are highly effective, low maintenance forms of birth control. Practice guidelines from the American College of Obstetricians and Gynecologists, American Academy of Family Physicians, and American Academy of Pediatrics recommend that LARC be considered first-line birth control for most women; however, uptake remains low. In this study, we sought to understand practices and barriers to provision of LARC in routine and immediate postpartum settings as they differ between specialties. Read More

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October 2018
9 Reads

Ultrasound imaging of the fetal secondary palate: methodological description of a two dimensional approach, and a case series.

Prenat Diagn 2018 Nov 7. Epub 2018 Nov 7.

OB-GYN Ultrasound Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Objective: to describe our two dimensional (2D) ultrasound approach to visualize the fetal secondary palate, and plot its growth curve, and to describe demonstrate its clinical implementation.

Methods: this is a two parts retrospective study. First, we measured the antero-posterior length of the bony secondary palate, from the soft to hard palate interface (SHPI) line to the alveolar ridge, blindly by two operators during routine scans of low risk fetuses, and plot a longitudinal growth curve. Read More

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November 2018

Choosing a women's health career.

BMC Med Educ 2018 Nov 6;18(1):251. Epub 2018 Nov 6.

Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, MD, USA.

Background: In 2005, in response to a decline in residency applications in obstetrics and gynecology (OB GYN), the American College of Obstetrics and Gynecology Presidential Task Force outlined strategies for attracting medical students to OB GYN. Application rates have increased since then, but little is known about which interventions are effective. We aimed to identify modifiable and nonmodifiable variables that may contribute to students choosing OB GYN for their careers; this information could be used to inform curriculum design, faculty development, and innovative exposures to women's health. Read More

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November 2018
1 Read

Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status.

Mol Neuropsychiatry 2018 Oct 5;4(2):90-99. Epub 2018 Sep 5.

Integrative Systems Biology, U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA.

DNA methylation patterns change with age and can be used to derive an estimate of "epigenetic age," an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated biological aging. This study examined associations between estimated epigenetic age and various variables in 160 male combat-exposed war veterans with ( = 79) and without PTSD ( = 81). Read More

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October 2018
4 Reads

Adherence to Consensus Guidelines for the Management of Labor Arrest Disorders in a Single Academic Tertiary Care Medical Center.

Am J Perinatol 2018 Nov 5. Epub 2018 Nov 5.

Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas.

Objective:  To evaluate the degree of adherence to the new the American College of Obstetricians and Gynecologists/Society for Maternal-Fetal Medicine guidelines in labor arrest management.

Study Design:  A retrospective study of term, live, singleton deliveries with intrapartum primary cesarean delivery solely for failed induction of labor or labor arrest. Adherence was defined according to the 2014 criteria. Read More

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November 2018
3 Reads

Treatment Attitudes for Belgian Women With Persistent Trichomonas vaginalis Infection in the VlaResT Study.

Clin Infect Dis 2018 Oct 12. Epub 2018 Oct 12.

Department of OB/Gyn, Antwerp University Hospital.

Background: Because of its increasing prevalence worldwide, its sexual transmissibility and its facilitation of human immunodeficiency virus transmission, Trichomonas vaginalis (TV) infection constitutes an important public health concern.

The Aim Of The Study: While searching for possible resistant TV cases, adequacy of management of TV-infected women was assessed.

Methods: Cervical cytology between July 2007 and July 2014 was tested with TV polymerase chain reaction, and 304 women expressed repeatedly positive results, 718 in total. Read More

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October 2018
2 Reads

Wingless promotes EGFR signaling in follicle stem cells to maintain self-renewal.

Development 2018 Dec 5;145(23). Epub 2018 Dec 5.

Center for Reproductive Sciences, Departments of Anatomy and OB/GYN-RS, University of California, San Francisco, CA 94143-0452, USA

Adult stem cell niche boundaries must be precisely maintained to facilitate the segregation of stem cell and daughter cell fates. However, the mechanisms that govern this process in epithelial tissues are not fully understood. In this study, we investigated the relationship between two signals, Wnt and EGFR, that are necessary for self-renewal of the epithelial follicle stem cells (FSCs) in the ovary, but must be downregulated in cells that have exited the niche to allow for differentiation. Read More

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December 2018

Visualising the boundary sharpness of uterine zonal structures using high-resolution T2-weighted images during the menstrual cycle.

Clin Radiol 2018 Oct 30. Epub 2018 Oct 30.

Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China. Electronic address:

Aim: To investigate whether there is an optimal time in the menstrual cycle to obtain the best image quality of uterine zonal structures with high-field magnetic resonance imaging (MRI).

Materials And Methods: Thirty-eight normal volunteers with regular menstrual cycles underwent pelvic 3 T high-resolution T2-weighted three-dimensional (3D) turbo spin echo (TSE) with variable flip angle MRI examinations during the menstrual phase (MP), follicular phase (FP), peri-ovulatory phase (OP), and luteal phase (LP). Two radiologists blinded evaluated the boundary sharpness of the three zonal structures of the uterine corpus and cervix on mid-sagittal images using a three-point Likert-scale. Read More

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October 2018
2 Reads

Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) - Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer.

Geburtshilfe Frauenheilkd 2018 Oct 19;78(10):949-971. Epub 2018 Oct 19.

Klinik für Gynäkologie und Geburtshilfe, Universitätsmedizin Göttingen, Göttingen, Germany.

The first German interdisciplinary S3-guideline on the diagnosis, therapy and follow-up of patients with endometrial cancer was published in April 2018. Funded by German Cancer Aid as part of an Oncology Guidelines Program, the lead coordinators of the guideline were the German Society of Gynecology and Obstetrics (DGGG) and the Gynecological Oncology Working Group (AGO) of the German Cancer Society (DKG). The use of evidence-based, risk-adapted therapy to treat low-risk women with endometrial cancer avoids unnecessarily radical surgery and non-useful adjuvant radiotherapy and/or chemotherapy. Read More

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October 2018
6 Reads

When Are Trainees Ready to Perform Transvaginal Ultrasound? An Observational Study.

Ultraschall Med 2018 Oct 25. Epub 2018 Oct 25.

Obstetrics and Fetal Medicine Department, Necker-Enfants-Malades-Hospital, APHP, Université Paris Descartes, Paris, France.

Purpose:  The purpose of this study was two-fold: (1) To determine how the number of ultrasound scans a trainee has completed predicts the trainee's diagnostic accuracy when performing transvaginal ultrasound examinations, and (2) to examine the utility of simulation-based assessment of ultrasound competence for determining readiness for independently performing examinations.

Materials And Methods:  101 OB/GYN trainees were surveyed regarding their clinical experience and the number of scans they had completed. All participants completed five different cases on a transvaginal virtual-reality ultrasound simulator (Scantrainer, Medaphor). Read More

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October 2018
4 Reads

Sugar-Sweetened Beverage Attitudes and Consumption During the First 1000 Days of Life.

Am J Public Health 2018 Dec 25;108(12):1659-1665. Epub 2018 Oct 25.

Jennifer A. Woo Baidal, Kayla Morel, Kelsey Nichols, and Erin Elbel are with the Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Medical Center, New, York, NY. Nalini Charles is with the New York Presbyterian Hospital Special Supplemental Nutrition, Program for Women, Infants, and Children, New York, NY. Jeff Goldsmith is with the Mailman School of Public Health, Columbia University Medical Center, New York, NY. Ling Chen is with the Department of Ob-Gyn, Columbia University Medical Center. Elsie M. Taveras is with the Division of General Academic Pediatrics, Department of Pediatrics, MassGeneral Hospital for Children, Boston, MA.

Objectives: To examine the relationship of parental sugar-sweetened beverage (SSB) attitudes with SSB consumption during the first 1000 days of life-gestation to age 2 years.

Methods: We studied 394 Special Supplemental Nutrition Program for Women, Infants, and Children (WIC)-enrolled families during the first 1000 days of life in northern Manhattan, New York, in 2017. In regression models, we assessed cross-sectional relationships of parental SSB attitude scores with habitual daily parent SSB calories and infant SSB consumption, adjusting for demographic and socioeconomic characteristics. Read More

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December 2018
7 Reads

Screen Identifies and Other Genetic Drivers in Human B-cell Lymphoma.

Mol Cancer Res 2018 Oct 24. Epub 2018 Oct 24.

Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.

Follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) are the most common non-Hodgkin lymphomas distinguishable by unique mutations, chromosomal rearrangements, and gene expression patterns. Here, it is demonstrated that early B-cell progenitors express 2',3'-cyclic-nucleotide 3' phosphodiesterase (CNP) and that when targeted with () mutagenesis, mutation or loss gave rise to highly penetrant lymphoid diseases, predominantly follicular lymphoma and DLBCL. In efforts to identify the genetic drivers and signaling pathways that are functionally important in lymphomagenesis, SB transposon insertions were analyzed from splenomegaly specimens of -mutagenized mice ( = 23) and -mutagenized mice on a background ( = 7) and identified 48 and 12 sites with statistically recurrent transposon insertion events, respectively. Read More

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October 2018
1 Read

A salpingeal carcinoma revealed after prophylactic salpingoophorectomy in an asymptomatic BRCA1 carrier with breast malignancy.

Int J Surg Case Rep 2018 12;52:107-110. Epub 2018 Oct 12.

1(st)OB.GYN Department, School of Medicine, National and Kapodistrian University of Athens, Alexandra Hospital, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece. Electronic address:

Introduction: BRCA1 inherited mutation carriers face a lifetime risk of 72% to develop breast cancer and a percentage of 44% risk for ovarian cancer.

Presentation Of Case: We present a case of a 35-year old Caucasian woman who, after the excision of a possible malignant finding on the right breast, was diagnosed with ductal breast carcinoma. The patient treatment included first chemotherapy and radiotherapy and then prophylactic bilateral mastectomy with plastic reconstructive surgery. Read More

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October 2018
1 Read

Effect of a surfactant-based gel on patient quality of life.

J Wound Care 2018 Oct;27(10):664-678

Head of Vascular Surgery Unit and Wound Centre, Department of Surgery, HFR Fribourg - Cantonal Hospital, Fribourg, Switzerland.

The characteristic clinical signs of chronic wounds, which remain in a state of prolonged inflammation, include increased production of devitalised tissue and exudate, pain and malodour. The presence of necrotic tissue, slough and copious exudate encourages microbial proliferation, potentially resulting in planktonic and/or biofilm infection. For patients, the consequences can include leakage of exudate, pain and reduced mobility, which can impair their ability to socialise and perform activities of daily living. Read More

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October 2018
3 Reads

Stress forces first lineage differentiation of mouse Embryonic Stem Cells, validation of a high throughput screen for toxicant stress.

Stem Cells Dev 2018 Oct 17. Epub 2018 Oct 17.

Wayne State University , Ob/Gyn and Anatomy and Cell Biology , 275 east hancock st , detroit, United States , 48236 ;

Mouse Embryonic Stem Cells (mESC) are unique in their self-renewal and pluripotency. Hypothetically, mESCs model gestational stress effects or stresses of in vitro fertilization/assisted reproductive technologies or drug/environmental exposures that endanger embryos. Testing mESCs stress responses should diminish and expedite in vivo embryo screening. Read More

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October 2018
4 Reads

McCarus Minimally Invasive Hysterectomy: 20 Years' Experience-Lessons Learned.

Authors:
Steven D McCarus

Surg Technol Int 2018 Nov;33:207-214

Division of Gynecologic Surgery, Florida Hospital Celebration Health, Department of OB/GYN, University of Central Florida, McCarus Surgical Specialists for Women, Orlando, Florida.

The advancement of surgical innovation for both devices and techniques has directly impacted the number of hysterectomy options available to patients. These advancements have led to an expansion of options that has been exceptionally impactful for minimally invasive surgery. For individuals who are diagnosed with a health condition or disease that requires a hysterectomy, these advances allow the surgeon to consider an expanded variety of procedures that may improve patients' outcomes and accommodate patient preferences. Read More

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November 2018
7 Reads

Bridging the Gap: Incorporating Simulation into Obstetrics and Gynaecology Undergraduate Medical Education.

J Obstet Gynaecol Can 2018 Oct 10. Epub 2018 Oct 10.

Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON; Department of Obstetrics and Gynaecology, St. Michael's Hospital, Toronto, ON.

Introduction: Currently, simulation training is not part of the clinical clerkship rotation in obstetrics and gynaecology (OB/GYN) at the University of Toronto. Instead, students are taught formally through lectures and informally on the ward or in the operating room. This study aimed to incorporate simulation using a high fidelity postpartum hemorrhage (PPH) workshop into the teaching curriculum, with the goal of improving both medical knowledge of PPH and nontechnical skills (NTS). Read More

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October 2018
1 Read

Continued Validation of Ultrasound Guidance Targeting Tasks: Assessment of Internal Structure.

Acad Radiol 2018 Oct 11. Epub 2018 Oct 11.

Division of Maternal Fetal Medicine, Department of OB-GYN, Wake Forest School of Medicine, Winston-Salem, NC 27157.

Rationale And Objectives: We previously demonstrated validity evidence for our novel ultrasound-guided invasive procedure targeting tasks in the content, response process, relations with other variables, and consequences validity domains. Here, we investigate their internal structure by assessing their interrater, intrarater, and test-retest reliability.

Methods: In thisInstitutional Review Board approved nonrandomized interventional trial first year medical students performed our previously described dowel and straw ultrasound guidance targeting tasks as a pretest. Read More

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October 2018
7 Reads

AP39, a Modulator of Mitochondrial Bioenergetics, Reduces Antiangiogenic Response and Oxidative Stress in Hypoxia-Exposed Trophoblasts: Relevance for Preeclampsia Pathogenesis.

Am J Pathol 2018 Oct 11. Epub 2018 Oct 11.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

Although the cause of preeclampsia, a pregnancy complication with significant maternal and neonatal morbidity, has not been fully characterized, placental ischemia attributable to impaired spiral artery remodeling and abnormal secretion of antiangiogenic factors are thought to be important in the pathogenesis of the disease. Placental ischemia could impair trophoblast mitochondrial function and energy production, leading to the release of reactive oxygen species (ROS). ROS have been shown to stabilize hypoxia-inducible factor (HIF)-1α, which, in turn, may induce transcription of antiangiogenic factors, soluble fms-like tyrosine kinase 1 (sFLT1), and soluble endoglin in trophoblasts. Read More

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October 2018
6 Reads

Patient knowledge and attitudes toward cervical cancer screening after the 2012 screening guidelines.

Patient Educ Couns 2018 Oct 3. Epub 2018 Oct 3.

Department of OB/GYN, Indiana University School of Medicine, Indianapolis, USA. Electronic address:

Objective: To assess women's attitudes and preferences related to recent changes in cervical cancer screening guidelines.

Methods: We distributed 380 surveys in three University based and Community clinics. Study participants anonymously completed surveys, which included questions related to demographics, cervical cancer, screening practices, risk perception and attitudes towards changing practices. Read More

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October 2018
1 Read

Cervical alterations in pregnancy.

Best Pract Res Clin Obstet Gynaecol 2018 Oct 11;52:88-102. Epub 2018 Apr 11.

Dept. of Mechanical Engineering, Columbia University, New York, NY, USA.

Spontaneous preterm birth (SPTB), defined as delivery before 37 weeks' gestation, remains a significant obstetric dilemma even after decades of research in this field. Although trends from 2007 to 2014 showed the rate of preterm birth slightly decreased, the CDC recently reported the rate of preterm birth has increased for two consecutive years since 2014. Currently, 1 in 10 pregnancies in the US still end prematurely. Read More

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October 2018

Gender trends in gynecologic oncology authorship: Implications for the critical evaluation of gender distribution in academic rank and leadership positions.

Gynecol Oncol 2018 Dec 9;151(3):542-546. Epub 2018 Oct 9.

Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Duke University Medical Center, Durham, NC 27710, United States of America. Electronic address:

Objective: To investigate trends in the representation of women as first, last, or co-authors in Gynecologic Oncology (GO) publications over the past 15 years. To compare rates of female authorship in GO versus general Obstetrics and Gynecology (Ob/Gyn) and with the gender distribution of membership in the Society of Gynecologic Oncology (SGO).

Methods: Gender was determined for first and last authors of GO publications from three major journals for 2000, 2005, 2010, and 2015. Read More

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December 2018

Ergonomics in gynecologic surgery.

Curr Opin Obstet Gynecol 2018 Dec;30(6):432-440

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of OB/GYN, Kaiser Permanente, San Diego, USA.

Purpose Of Review: Work-related musculoskeletal disorders (WMSDs) are prevalent among surgeons and result in significant disability. We aimed to review the English-language literature regarding ergonomic risk, prevalence of WMSDs, and unique ergonomic considerations of gynecologic surgery.

Recent Findings: Surgeon WMSDs are prevalent, with rates ranging from 66 to 94% for open surgery, 73-100% for conventional laparoscopy, 54-87% for vaginal surgery, and 23-80% for robotic-assisted surgery. Read More

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December 2018
7 Reads

More women gynecologists in Belgium: assessment of changes in the workforce-a survey.

Arch Gynecol Obstet 2018 Dec 8;298(6):1139-1148. Epub 2018 Oct 8.

Department of Obstetrics and Gynecology, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.

Context And Objective: International data highlight the increasing participation of women in the workforce in the medical field and particularly among obstetricians and gynecologists (OB-GYN). Some studies reported a gender difference in work productivity and practice patterns. The aim of this study is to analyze whether disparities exist between male and female OB-GYN in their practices with potential consequences for the organization of the OB-GYN departments. Read More

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December 2018
8 Reads

Concerns about the review of vaginal progesterone and the vaginal first-pass effect.

Climacteric 2018 Oct 8. Epub 2018 Oct 8.

a Department of Ob/Gyn and Centre for Perinatal and Reproductive Medicine , Santa Maria della Misericordia University Hospital , Perugia , Italy.

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October 2018
2 Reads

Burnout, perceived stress, and empathic concern: differences in female and male Millennial medical students.

Psychol Health Med 2018 Oct 7:1-10. Epub 2018 Oct 7.

c Department of Physical Medicine and Rehabilitation , The Ohio State University College of Medicine , Columbus , OH , USA.

The 'Millennial' generation faces medical education learning environment challenges differently. We explore gender differences in burnout, perceived stress, and empathic concern in third-year medical students. A sample size of 654 third-year medical students completed an annual survey over 6 years. Read More

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October 2018
2 Reads

Is multiple-site colonization with Candida spp. related to inadequate response to individualized fluconazole maintenance therapy in women with recurrent Candida vulvovaginitis?

Diagn Microbiol Infect Dis 2018 Nov 2;92(3):226-229. Epub 2018 Jun 2.

Femicare vzw, Tienen.

Objective: Although most women on fluconazole maintenance therapy for recurrent vulvovaginal candidosis experience a substantial improvement in quality of life, some do not respond to therapy. Is candidal colonization of extragenital sites related to suboptimal response to maintenance therapy?

Patients And Methods: Women included in a multicenter follow-up study (ReCiDiF) were evaluated for clinical signs and presence of yeasts in nose, mouth, anus, perineum, and urine. Candida was diagnosed by positive microscopy, confirmed by positive culture or polymerase chain reaction. Read More

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November 2018
2 Reads

COMFFETI, Combined Fresh and Frozen Embryo Transfers per Individual: A New Index of Quality Control for The Performance of emberyologic Labs in The Emerging Era of Segmentation of Cycle and Freeze-All Strategy.

Int J Fertil Steril 2019 Jan 2;12(4):339-342. Epub 2018 Oct 2.

Aristotle University of Thessaloniki, 3rd Department Ob Gyn, Thessaloniki, Greece.Electronic

The efficacy of fertilization (IVF) for treating human infertility has only one final efficacy index and that is the achievement of a delivery. However, with the evolution of the freeze-all strategy, a new problem is arising for evaluating the performance of an embryological team. The aim of the study was to present a new representative index, combining fresh and frozen embryo transfer success rates. Read More

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January 2019
18 Reads