9,682 results match your criteria ORL: Journal for Oto-Rhino-Laryngology and its Related Specialties [Journal]


Physical Activity Program Improves Functional Exercise Capacity and Flexibility in Extremely Preterm Children With Bronchopulmonary Dysplasia Aged 4-6 Years: A Randomized Controlled Trial.

Arch Bronconeumol 2018 Dec 4;54(12):607-613. Epub 2018 Jul 4.

Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL & Dermatologie, Université Catholique de Louvain, 1200 Bruxelles, Belgium; Service de Médecine Physique et Réadaptation, Cliniques universitaires Saint-Luc, 1200 Bruxelles, Belgium; Service de Pneumologie, Cliniques universitaires Saint-Luc, 1200 Bruxelles, Belgium.

Introduction: Bronchopulmonary dysplasia (BPD) is the most common complication of extreme preterm delivery, and is associated with reduced exercise tolerance and exercise capacity. The aim of this study was to assess the effects of a physical activity programme on exercise tolerance, exercise capacity, flexibility, and lung function in prematurely born children with BPD.

Methods: This was a randomized controlled trial. Read More

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December 2018

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells.

Cell 2018 Nov 13. Epub 2018 Nov 13.

Innate Pharma, 117 Avenue de Luminy, 13009 Marseille, France; Aix Marseille Université, INSERM, CNRS, Centre d'Immunologie de Marseille-Luminy, 13009 Marseille, France; Service d'Immunologie, Marseille Immunopole, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France. Electronic address:

Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of patients respond to these immunotherapies. Here, we report that blocking the inhibitory NKG2A receptor enhances tumor immunity by promoting both natural killer (NK) and CD8 T cell effector functions in mice and humans. Read More

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November 2018

Flipped classroom frameworks improve efficacy in undergraduate practical courses - a quasi-randomized pilot study in otorhinolaryngology.

BMC Med Educ 2018 Dec 4;18(1):294. Epub 2018 Dec 4.

Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr University Bochum, St. Elisabeth-Hospital, Bleichstr. 15, 44787, Bochum, Germany.

Background: Curriculum design and specific topic selection for on-site practical courses in clinical disciplines with limited teaching time is challenging. An electronic learning supported curriculum based on the flipped classroom principle has a high potential to effectively gain knowledge and education along with improving practical experience. Here, we demonstrate the introduction of a flipped classroom curriculum for practical courses in Otorhinolaryngology (ORL) in real world practice to improve the on-site time management and students' experience. Read More

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December 2018

Altération de la fonction auditive.

Rev Prat 2017 Feb;66(2):e75-e84

Service ORL, hôpital Rothschild, 75012 Paris, France.

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February 2017

Relations pathologiques entre dents et sinus maxillaire.

Rev Prat 2016 Mar;66(3):309-314

Service d'ORL et de chirurgie cervico-faciale, hôpital d'instruction des armées Percy, Clamart, France.

Pathological link between teeth and maxillary sinus. Pathological relationship between the teeth and the maxillary sinus can be explained by their embryological and anatomical relationships. The floor is centered by the apex of antral teeth: premolars and first molars. Read More

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Adénopathies superficielles de l’adulte et de l’enfant.

Rev Prat 2016 May;66(5):e217-e223

Service d'hématologie et d'oncologie, Hôpitaux universitaires de Strasbourg, France.

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Enquête diagnostique devant une adénopathie.

Rev Prat 2016 May;66(5):e216

Service d'hématologie et d'oncologie, Hôpitaux universitaires de Strasbourg, France.

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Tumors of upper aerodigestive tract

Rev Prat 2017 12;67(10):e519

Service ORL et chirurgie cervico-faciale, CHU Toulouse, hôpital Rangueil-Larrey, 31000 Toulouse, France.

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December 2017

Tumors of the oral cavity, naso-sinus and cavum, and upper aerodigestive tract

Rev Prat 2017 12;67(10):e511-e518

Service ORL et chirurgie cervico-faciale, CHU Toulouse, hôpital Rangueil-Larrey, 31000 Toulouse, France.

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December 2017

Considerations when selecting pharmacotherapy for nicotine dependence.

Expert Opin Pharmacother 2018 Nov 29:1-6. Epub 2018 Nov 29.

a School of Medicine , IMPACT SRC, Deakin University , Geelong , Australia.

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November 2018

The COMiT'ID Study: Developing Core Outcome Domains Sets for Clinical Trials of Sound-, Psychology-, and Pharmacology-Based Interventions for Chronic Subjective Tinnitus in Adults.

Trends Hear 2018 Jan-Dec;22:2331216518814384

1 National Institute for Health Research Nottingham Biomedical Research Centre, Ropewalk House, UK.

Subjective tinnitus is a chronic heterogeneous condition that is typically managed using intervention approaches based on sound devices, psychologically informed therapies, or pharmaceutical products. For clinical trials, there are currently no common standards for assessing or reporting intervention efficacy. This article reports on the first of two steps to establish a common standard, which identifies what specific tinnitus-related complaints ("outcome domains") are critical and important to assess in all clinical trials to determine whether an intervention has worked. Read More

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November 2018
3 Reads

The Difficult Secondary Tracheoesophageal Puncture: A Technique for Safe Insertion.

ORL J Otorhinolaryngol Relat Spec 2018 Nov 28;81(1):10-15. Epub 2018 Nov 28.

Background/aims: The tracheoesophageal prothesis (TEP) has become the primary modality for laryngeal communication after total laryngectomy due to high success rates, minimal morbidity, and more natural pulmonary driven speech. Fibrosis, kyphosis, and post-radiation contracture may preclude TEP placement through rigid esophagoscopy, and certain patients may not tolerate an in-office awake procedure. For such patients, a technique for flexible esophageal stenting and TEP placement is necessary. Read More

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November 2018
3 Reads

The association between hearing impairment and neural envelope encoding at different ages.

Neurobiol Aging 2018 Oct 11;74:202-212. Epub 2018 Oct 11.

KU Leuven - University of Leuven, Department of Neurosciences, Research Group Experimental ORL (ExpORL), Leuven, Belgium.

Hearing impairment goes with speech perception difficulties, presumably not only because of poor hearing sensitivity but also because of altered central auditory processing. Critical herein is temporal processing of the speech envelope, mediated by synchronization of neural activity to the envelope modulations. It has been suggested that hearing impairment is associated with enhanced sensitivity to envelope modulations which, in turn, relates to poorer speech perception. Read More

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October 2018
1 Read

Clinical efficacy of intranasal drug delivery by nebulization in chronic rhinosinusitis: a systematic review.

Rhinology 2018 Nov 24. Epub 2018 Nov 24.

Service d'Oto-rhino-laryngologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.

Background: Treatment of chronic rhinosinusitis (CRS) aims to treat the underlying inflammation or infection. Although the optimal modality of administration remains controversial, inhalation route is usually preferred. The aim of this systematic review was to summarize the efficacy of intranasal corticoisteroids or antibiotics delivery by nebulization on symptoms, histology, endoscopy scores, nasal obstruction, clinical outcomes and quality of life in CRS. Read More

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November 2018
1 Read

A New Formula for Predicting the Fraction of Delivered Oxygen During Low-Flow Oxygen Therapy.

Respir Care 2018 Dec;63(12):1528-1534

Institut de Recherche Experimentale et Clinique (IREC), Pole de Pneumologie, ORL & Dermatologie, Service de Pneumologie, Universite Catholique de Louvain, Brussels, Belgium.

Background: During O therapy at low flow in patients who breathe spontaneously, the fraction of delivered O (F ) is unknown. In recent years, F prediction formulas have been proposed. However, they do not take into account the effect of inspiratory flow (V̇) on the F . Read More

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December 2018
1 Read

Cluster Analysis of Chronic Rhinosinusitis Suggests Gender-Based Differences.

ORL J Otorhinolaryngol Relat Spec 2018 Nov 20;81(1):1-9. Epub 2018 Nov 20.

Department of Otorhinolaryngology and Head and Neck Surgery, Zagreb School of Medicine, University Hospital Centre Sestre Milosrdnice, Zagreb, Croatia.

Purpose: We aimed to evaluate the interaction between the overall severity of chronic rhinosinusitis (CRS) before treatment and subjective improvement following surgical or medical treatment.

Procedures: A group of 97 patients with CRS completed the visual analog scale (VAS) symptom score and the Sino-Nasal Outcome Test 22 (SNOT-22) questionnaire in the moment of their sinus computerized tomography (CT) scan. Data were analyzed via a 2-step cluster analysis based on gender, polyp presence, CT scan, and VAS scores for symptoms. Read More

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November 2018
2 Reads

Single Retinal Layer Changes After Subthreshold Micropulse Yellow Laser in Diabetic Macular Edema.

Ophthalmic Surg Lasers Imaging Retina 2018 Nov;49(11):e218-e225

A pilot prospective, interventional study has been conducted on 10 patients with diabetic macular edema (DME) treated with subthreshold micropulse laser (SMPL) to evaluate changes of individual retinal layers and to correlate with functional changes. All patients underwent complete ophthalmologic evaluation including spectral-domain optical coherence tomography (OCT) and microperimetry at baseline, 3 months, 6 months, 9 months, and 12 months. Compared with baseline, a significant decrease was found in inner nuclear layer (INL) and outer retinal layer (ORL) thickness in the central 1 mm (P < . Read More

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November 2018

Three-dimensional structure of the orbicularis retaining ligament: an anatomical study using micro-computed tomography.

Sci Rep 2018 Nov 19;8(1):17042. Epub 2018 Nov 19.

Department of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea.

The orbicularis retaining ligament (ORL) is an important structure for maintaining the eyelid and cheek skin and contouring the characteristic facial appearance. However, the ORL is a delicate structure that is easily damaged in manual dissection. This study aimed to comprehensively investigate the ORL using a micro-computed tomography (mCT) with phosphotungstic acid (PTA) preparation for the acquisition of its three-dimensional information non-destructively. Read More

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November 2018
2 Reads

Impact of cochlear implantation on peripheral vestibular function in adults.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec 25;135(6):417-420. Epub 2018 Oct 25.

Service ORL, CHU de Saint-Étienne, 42270 Saint-Priest-en-Jarez, France.

Objective: Cochlear implantation may have a detrimental effect on vestibular function and residual hearing. Our goal was to investigate the impact of cochlear implantation on peripheral vestibular function and the symptomatology that ensues.

Material And Methods: A prospective observational study included all adults undergoing cochlear implantation by the same operator between July 2014 and December 2015, with pre- and postoperative (4 months) neurovestibular balance examination comprising a questionnaire and clinical tests [head impulse test (HIT), head-shaking test (HST), skull vibration test (SVT)] and instrumental tests [caloric test of the lateral semicircular canal and cervical vestibular-evoked myogenic potentials (cVEMP)]. Read More

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December 2018
4 Reads

Complications of using Gore-Tex in medialization laryngoplasty: case series and literature review.

Eur Arch Otorhinolaryngol 2018 Nov 13. Epub 2018 Nov 13.

Department of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Purpose: This study was performed to evaluate the incidence and contributing factors of complications associated with medialization laryngoplasty using Gore-Tex in patients with unilateral vocal fold paralysis.

Methods: A retrospective chart review was conducted for all patients who underwent medialization laryngoplasty using Gore-Tex at Tohoku University Hospital between January 2014 and April 2018. A search of series and case reports in PubMed was performed to determine the incidence of complications following medialization laryngoplasty using Gore-Tex. Read More

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November 2018
17 Reads

Absorption of blue light by cigarette smoke components is highly toxic for retinal pigmented epithelial cells.

Arch Toxicol 2018 Nov 13. Epub 2018 Nov 13.

Centre de Recherche du CHU de Québec-Université Laval, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, QC, Canada.

Lesion to the retinal pigment epithelium (RPE) is a crucial event in the development of age-related macular degeneration (AMD), the leading cause of blindness in industrialized countries. Tobacco smoking and high-energy visible blue (HEV; 400-500 nm) light exposure are major environmental risk factors for AMD. Individually, they have been shown to cause damage to the RPE. Read More

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November 2018
3 Reads

Salivary duct carcinoma: A prospective multicenter study of 61 cases of the Réseau d'Expertise Français des Cancers ORL Rares.

Head Neck 2018 Nov 13. Epub 2018 Nov 13.

Réseau d'Expertise Français des Cancers ORL Rares: (REFCOR, French Rare Head and Neck Cancer Expert Network): S. Albert, G. Andry, E. Babin, C. Bach, J.-M. Badet, C. Badoual, A.C. Baglin, A. Banal, B. Barry, E. Baudin, B. Baujat, R.J. Bensadoun, C. Bertolus, J.-P. Bessède, D. Blanchard, C. Borel, A. Bozorg-Grayeli, R. Breheret, P. Breton, L. Brugel, G. Calais, O. Casiraghi, E. Cassagnau, L. Castillo, P. Ceruse, F. Chabolle, D. Chevalier, J.C. Chobaut, O. Choussy, A. Cosmidis, A. Coste, V. Costes, L. Crampette, V. Darrouzet, P. Demez, P. Dessi, B. Devauchelle, G. Dolivet, F. Dubrulle, S. Duflo, X. Dufour, S. Faivre, N. Fakhry, C. Ferron, F. Floret, L. de Gabory, R. Garrel, L. Geoffrois, L. Gilain, A. Giovanni, A. Girod, B. Guerrier, S. Hans, P. Herman, P. Hofman, M. Housset, R. Jankowski, F. Jegoux, M. Juliéron, M.-C. Kaminsky, F. Kolb, J. Lacau St Guily, L. Laccoureye, B. Lallemant, P. Lang, E. Lartigau, J.-P. Lavieille, M. Lefevre, X. Leroy, O. Malard, F. Massip, O. Mauvais, J.-C. Merol, J. Michel, T. Mom, S. Morinière, E. de Monès, G. Moulin, G. Noel, G. Poissonnet, J.-M. Prades, D. de Raucourt, E. Reyt, C. Righini, Y. Marie Robin, F. Rolland, B. Ruhin, N. Sarroul, P. Schultz, E. Serrano, O. Sterkers, V. Strunski, A. Sudaka, M. Tassart, S. Testelin, J. Thariat, A. Timochenko, B. Toussaint, E. Uro Coste, G. Valette, T. Van den Abbeele, A. Varoquaux, F. Veillon, S. Vergez, M. Wassef.

Background: The purposes of this study were to describe the characteristics of a prospective multicenter series of patients with salivary duct carcinoma and to investigate prognostic factors.

Methods: Patients included for salivary duct carcinoma between 2009 and 2016 in the Réseau d'Expertise Français des Cancers ORL Rares (REFCOR) database were selected. Immunohistochemical analyses were performed. Read More

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November 2018
2 Reads
2.640 Impact Factor

Transoral Robotic Surgery and the Unknown Primary.

ORL J Otorhinolaryngol Relat Spec 2018 12;80(3-4):148-155. Epub 2018 Nov 12.

University of Pittsburgh, Department of Otolaryngology, Eye & Ear Institute, Veterans Affairs Pittsburgh Health System, Pittsburgh, Pennsylvania, USA.

Carcinoma of unknown primary (CUP) comprises approximately 1%-5% of all head and neck malignancies. Primary site detection rates for metastatic cervical squamous cell carcinoma (SCC) remain variable, with current diagnostic imaging unable to identify all tumours. Prevailing evidence suggests that most head and neck CUP are located in the oropharynx. Read More

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November 2018
3 Reads

Erratum of "Laryngeal electromyography in dysphonic patients with incomplete glottic closure".

Braz J Otorhinolaryngol 2018 Nov - Dec;84(6):806

Professor Titular pelo Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço da Universidade Federal de São Paulo/Escola Paulista de Medicina (Presidente da IFOS (International Federation of ORL Societies)), Universidade Federal de São Paulo/Escola Paulista de Medicina.

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November 2018

Registered nurses' knowledge and care practices regarding patients with dysphagia in Saudi Arabia.

Int J Health Care Qual Assur 2018 Oct;31(8):896-909

Otorhinolaryngology (ORL) Department/Audiology, Speech, and Swallowing Unit, King Abdulaziz University Hospital , Jeddah, Saudi Arabia.

Purpose: The purpose of this paper is to assess the knowledge and practices of nursing staff caring for patients with dysphagia to determine any needs for further education programmes.

Design/methodology/approach: A self-administered questionnaire with close-ended questions was completed by nurses at a tertiary hospital in Saudi Arabia to measure the depth of their dysphagia knowledge.

Findings: From 316 potential participants, a sample of 174 nurses completed the questionnaire. Read More

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October 2018
6 Reads

Assessment of short-term exposure to an ultrasonic rodent repellent device.

J Acoust Soc Am 2018 Oct;144(4):2501

Department of Physics and Astronomy, Division of Soft Matter and Biophysics, Laboratory of Acoustics, KU Leuven, Celestijnenlaan 200D, B-3001 Heverlee, Belgium.

The objectives of the present study were to investigate the acoustical properties of the very high frequencies and/or ultrasound signals produced by a repellent device and to investigate potential adverse factors as a result of short-term exposure to these signals. Potential adverse effects were evaluated perceptually with 25 young and 25 middle-aged persons, all with normal hearing thresholds, in a quiet room using different outcome measures, including a 15-item survey presented before and immediately after each condition. Spectral analyses showed that, besides emitting frequency modulated sounds in the expected frequency ranges, a faint but audible sound in the 4-5 kHz range was present. Read More

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October 2018
3 Reads

Next-Generation Robotic Head and Neck Surgery.

ORL J Otorhinolaryngol Relat Spec 2018 7;80(3-4):213-219. Epub 2018 Nov 7.

Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University, Palo Alto, California,

Following the inception of transoral robotic surgery (TORS) in 2005, the field of robotic head and neck surgery has undergone refinement and innovation. Optimizing patient outcome, preserving function, and limiting morbidity are the key drivers. The next leap forward is another generation of flexible robotic surgical systems. Read More

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November 2018
4 Reads

Transoral Robotic Surgery Total Laryngectomy.

ORL J Otorhinolaryngol Relat Spec 2018 5;80(3-4):171-177. Epub 2018 Nov 5.

Department of Otolaryngology Head and Neck Surgery, CHU UCL Dinant Godinne, Yvoir, Belgium.

Objective: The aim of our study is to demonstrate our technique for performing transoral robotic surgical total laryngectomy (TORS-TL) with the use of the da Vinci robotic system.

Materials And Methods: We provide a comprehensive description of the TORS-TL operative techniques. Two fresh-frozen human cadavers were selected after ethics approval to describe the appropriate step-by-step surgical resection. Read More

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November 2018
3 Reads

Robot-Assisted Reconstruction in Head and Neck Surgical Oncology: The Evolving Role of the Reconstructive Microsurgeon.

ORL J Otorhinolaryngol Relat Spec 2018 5;80(3-4):178-185. Epub 2018 Nov 5.

The Royal Marsden NHS Foundation Trust, London, United Kingdom.

Transoral robotic surgery (TORS) is gaining more widespread use among head and neck surgical procedures. As experience grows with this technique, so do the indications of when and in which patients it can be used. Already established in the treatment of small oral cavity tumours, it is expanding into larger multi-site resections and resections, such as through-and-through-into-the-neck defects, that will require reconstruction. Read More

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November 2018
1 Read

Interest of video-otoscopy for the general practitioner.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Nov 1. Epub 2018 Nov 1.

Faculté de médecine de Tours, université François-Rabelais de Tours, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours, France; Service ORL et chirurgie cervico-faciale, CHRU de Tours, boulevard Tonnellé, 37044 Tours, France. Electronic address:

Introduction: General practitioners (GPs) play an essential role in the management of ear disease, but their diagnosis of pathologic eardrums is inadequate. The aim of this study was to compare the quality of otoscopic diagnosis by GPs using a conventional otoscope versus a video-otoscope. Subjects and method Eleven GPs included 124 patients with ear complaints (193 otoscopies). Read More

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November 2018
3 Reads

Posttraumatic sigmoid sinus thrombosis secondary to transmastoid foreign body.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Oct 30. Epub 2018 Oct 30.

Service ORL et chirurgie cervicofaciale, hôpital Nord, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France.

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October 2018

Extracellular vesicles in liver disease and beyond.

World J Gastroenterol 2018 Oct;24(40):4519-4526

Department of Immunology, Ophthalmology and ORL, Complutense University School of Medicine, Madrid 28040, Spain.

Extracellular vesicles (EVs) are membrane-derived vesicles which can be released by different cell types, including hepatocytes, hepatic stellate cells and immune cells in normal and pathological conditions. EVs carry lipids, proteins, coding and non-coding RNAs and mitochondrial DNA causing modifications on the recipient cells. These vesicles are considered potential biomarkers and therapeutic agents for human diagnostic and prognostic due to their function as intercellular mediators of cell-cell communication within the liver and between other organs. Read More

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October 2018
2 Reads

SEQUENTIAL PNEUMATIC RETINOPEXIES FOR THE TREATMENT OF PRIMARY INFERIOR RHEGMATOGENOUS RETINAL DETACHMENTS WITH INFERIOR BREAKS: The Double-Bubble Approach.

Retina 2018 Oct 29. Epub 2018 Oct 29.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Purpose: To evaluate a new approach of sequential pneumatic retinopexies for the management of inferior rhegmatogenous retinal detachments (RD) with inferior breaks.

Methods: Multicenter retrospective consecutive case series of inferior RDs caused by retinal breaks located within the inferior 4 clock hours treated with sequential pneumatic retinopexies, 24 to 48 hours apart. A total of 26 patients with inferior RDs secondary to one or more breaks between the 4 o'clock and 8 o'clock meridians were included from September 2007 to February 2012. Read More

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October 2018
1 Read
3.240 Impact Factor

Pediatric thyroid surgery: experience in 75 consecutive thyroidectomies.

Eur Arch Otorhinolaryngol 2018 Oct 31. Epub 2018 Oct 31.

Services d'ORL et Chirurgie Cervico Faciale & ORL pédiatrique, CHRU de TOURS, Université de TOURS, 37044, Tours cedex 9, France.

Objectives: The main objective of this study is to report our experience in a university hospital in the surgical management of thyroid disease in pediatric patients. We also aim to analyze the results and evaluate the efficacy of fine-needle aspiration biopsy (FNAB) and frozen section analysis.

Methods: A retrospective review of thyroid surgeries from January 1997 to December 2017 was conducted. Read More

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October 2018
3 Reads

Sialendoscopy for Definitive Management of a Submandibular Abscess following Radiotherapy for Oropharyngeal Squamous Cell Carcinoma.

ORL J Otorhinolaryngol Relat Spec 2018 Oct 31:1-4. Epub 2018 Oct 31.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA.

Background/aims: Sialendoscopy has as yet been shown to be ideal for the management of sialolithiasis and chronic inflammatory diseases of the salivary gland. However, its applicability to the management of a broad range of salivary gland disease is continually growing.

Methods: Here we present a case report where sialendoscopy was used to successfully manage an intraparenchymal submandibular gland abscess in a patient with oropharyngeal squamous cell carcinoma managed with primary chemoradiation. Read More

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October 2018
5 Reads

Retinal glial changes in Alzheimer's disease - A review.

J Optom 2018 Oct 27. Epub 2018 Oct 27.

Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, Spain; Facultad de Óptica y Optometría, Departamento de Inmunología, Oftalmología y ORL, Universidad Complutense de Madrid, Spain. Electronic address:

Alzheimer's disease (AD) is a neurodegenerative dementia characterized by the deposition of extracellular β-amyloid (Aβ) plaques and the presence of neurofibrillary tangles. Until now, the techniques used to analyze these deposits have been difficult to access, invasive, and expensive. This leads us to consider new access routes to the central nervous system (CNS), allowing us to diagnose the disease before the first symptoms appear. Read More

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October 2018
2 Reads

Spinal Surgery With Electrically Evoked Potential Monitoring and Monopolar Electrocautery: Is Prior Removal of a Cochlear Implant Necessary?

Otol Neurotol 2018 Oct 26. Epub 2018 Oct 26.

Department of ORL, University of Basel Hospital, Basel, Switzerland.

: Transcranial electric stimulation to generate motor evoked potentials in lower limb muscles is the standard technique used to monitor spinal cord efferent pathways during surgical correction for spinal deformities. Monopolar electrical cauterization is also used by default in the thoracic and lumbar area of the spine during this kind of surgery to prevent major blood loss. Owing to the high levels of current used, both techniques are considered contraindicative if the patient has a cochlear implant (CI). Read More

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October 2018
3 Reads

Otological surgery in paediatric photosensitive patients.

Int J Pediatr Otorhinolaryngol 2018 Dec 15;115:175-176. Epub 2018 Sep 15.

Great Ormond Street Hospital, London, UK.

There are a wide range of genetic and auto-immune conditions where UV light exposure poses a threat of UV irradiation to the external auditory canal, tympanic membrane and surrounding skin. Preoperative Ultraviolet Light (UV) measurements were taken in the operating theatre with standard operating microscope and an approved UV light meter prior to surgery on a patient with xeroderma pigmentosa. UV light meter readings of UV index 75 were taken at an operating distance of 290mm. Read More

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December 2018
4 Reads

Propofol sedation in Drug Induced Sedation Endoscopy without an anaesthesiologist - a study of safety and feasibility.

Rhinology 2018 Oct 26. Epub 2018 Oct 26.

Department of ORL, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Propofol sedation in Drug Induced Sedation Endoscopy (DISE) of the upper airway of patients with obstructive sleep apnea (OSA) without the presence of anesthesiologist has not been done before. Propofol sedation is normally administered by an anesthesiologist. This is the first study of this new method. Read More

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October 2018
5 Reads

Identification of phonological processes in Arabic-speaking Egyptian children by single-word test.

J Commun Disord 2018 Oct 15. Epub 2018 Oct 15.

Phoniatric Unit, ORL Department, Mansoura General Hospital, Mansoura, Egypt. Electronic address:

Purpose: Phonological processes are systematic changes in sound classes, sound sequences or syllable structure. The aim of this study was to develop an assessment tool for identification of developmental phonological processes in Arabic-speaking Egyptian children in order to provide normative data of phonological processes in typically developing children and distinguish between normal children and children with phonological impairment.

Method: The study design was a cross-sectional descriptive one. Read More

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October 2018
6 Reads

Combined Growth Factor and Gene Therapy: An Approach for Hair Cell Regeneration and Hearing Recovery.

ORL J Otorhinolaryngol Relat Spec 2018 Oct 25:1-12. Epub 2018 Oct 25.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Introduction: Fibroblast growth factor, nerve growth factor neurotrophins, and insulin-like growth factor 1 are considered 3 families of growth factors that can be involved in the process of otic neurogenesis. In this respect, otic neurons can also be connected with mechanoreceptors in the ear, the hair cells (HCs), as well as the central nervous system. As a growth factor is combined with gene transfer technology, it can be used for hair cell regeneration. Read More

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October 2018
4 Reads

Therapeutic use of the HPV vaccine on recurrent respiratory papillomatosis: a systematic review and meta-analysis.

J Infect Dis 2018 Oct 25. Epub 2018 Oct 25.

Department of ORL-Head & Neck Surgery and Audiology, Odense University Hospital, Denmark.

Background: Recurrent respiratory papillomatosis is a benign condition caused by human papilloma virus (HPV). Surgery is the mainstay of treatment, but numerous adjuvant therapies have been applied to improve surgical outcome. Recently, HPV vaccination has been introduced, but only smaller studies of its effect have been published. Read More

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October 2018
1 Read

Therapeutic potential of Focal Adhesion Kinase inhibition in small cell lung cancer.

Mol Cancer Ther 2018 Oct 23. Epub 2018 Oct 23.

Division of Pneumology, CHU UCL Namur

Small cell lung cancer (SCLC) has a poor prognosis. Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase regulating cell proliferation, survival, migration, and invasion, which is overexpressed and/or activated in several cancers, including SCLC. We wanted to determine whether FAK contributes to SCLC aggressive behavior. Read More

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October 2018
1 Read

Binaural Perception in Single-Sided Deaf Cochlear Implant Users with Unrestricted or Restricted Acoustic Hearing in the Non-Implanted Ear.

Audiol Neurootol 2018 23;23(3):187-197. Epub 2018 Oct 23.

CHRU de Tours, Service ORL et Chirurgie Cervico-Faciale, Tours,

Cochlear implantation (CI) can benefit patients with single-sided deafness (SSD) in terms of sound localization, speech understanding in noise, tinnitus severity, and quality of life (QoL). In previous studies, CI outcomes have been largely reported for SSD patients with normal "unrestricted" hearing in the contralateral ear. However, SSD patients may often have some degree of hearing loss in the contralateral ear ("restricted" acoustic hearing). Read More

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October 2018

A new experience of auditory brainstem implantation in Malaysia.

Med J Malaysia 2018 Oct;73(5):347-348

Sarawak General Hospital, Departmwnt of Neurosurgical, Sarawak, Malaysia.

Auditory brainstem implantation (ABI) is the only solution to restore hearing when cochlear nerves are disrupted together with the pathologies where bilateral cochleae do not provide a suitable location for cochlear implantation. We reported first two successful auditory brainstem implantation cases in patients with neurofibromatosis Type II (NF2) with bilateral acoustic neuroma causing bilateral profound sensorineural hearing loss in Malaysia. A good candidate selection, dedicated surgeons and rehabilitation team as well as strong family support are the crucial factors in achieving the best possible surgical, audiological and speech outcomes. Read More

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October 2018
4 Reads

Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study.

Clin Epidemiol 2018 12;10:1479-1487. Epub 2018 Oct 12.

Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark,

Background: The incidence and prevalence of multiple endocrine neoplasia 2A (MEN2A) have only been reported once in a nationwide setting. However, it is unclear whether the figures are representative of other populations, as the major component of the syndrome, hereditary medullary thyroid carcinoma (MTC), has been reported as rare in the same country. We conducted a nationwide retrospective cohort study of MEN2A in Denmark from 1901 to 2014, aiming to describe the incidence and prevalence. Read More

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October 2018
8 Reads

Maxillary sinus pain with radiolucent sinuses due to agenesis of the membranous ostium.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Oct 18. Epub 2018 Oct 18.

Service ORL et chirurgie cervico-faciale, hôpitaux de Brabois, centre hospitalier universitaire de Nancy, CHRU Nancy, rue du Morvan, 54511 Vandoeuvre-les-Nancy cedex, France.

Introduction: The absence of opacities on CT scan usually eliminates paranasal sinus disease as a cause of facial pain. The authors report a case, which constitutes an exception to this general rule, corresponding to a new aetiology of sinus pain.

Case Report: A 16-year-old boy presented with very painful "recurrent acute sinusitis" triggered by pressure changes (altitude, diving, surfing), with no sinus opacity on CT scan. Read More

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October 2018
4 Reads

Increased IgA Expression in Lung Lymphoid Follicles in Severe COPD.

Am J Respir Crit Care Med 2018 Oct 19. Epub 2018 Oct 19.

Université Catholique de Louvain (UCL), Institut de Recherche Expérimentale & Clinique (IREC), Pôle de Pneumologie, ORL & Dermatologie , Brussels, Belgium.

Rationale: Accumulation of B cells and lymphoid follicles (LF) has been described in chronic obstructive pulmonary disease (COPD) airways, but the functional status of lung B cells remains poorly known.

Objectives: The aim of this study was to characterize LF for expression of IgA, the main mucosal antibody.

Methods: The presence of B cells and LF, including intra-follicular IgA expression, were determined in the lung from COPD patients (n=37) versus controls (n=34) by immunohistochemistry. Read More

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October 2018
8 Reads

Arterial Blood Supply of the Nose: An Angiographic Study.

ORL J Otorhinolaryngol Relat Spec 2018 Oct 18:1-10. Epub 2018 Oct 18.

Otorhinolaryngology, Ain Shams University Faculty of Medicine, Cairo, Egypt.

Objective: To define anatomical variations associated with arterial blood supply of the nose which has clinical implications on the management of different disorders, especially intractable posterior epistaxis.

Study Design: Case series.

Methods: Selective angiography of external and internal carotid arteries of 100 patients scheduled for routine angiography was done. Read More

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October 2018
1 Read
0.670 Impact Factor

Early Sentence Recognition in Adult Cochlear Implant Users.

Ear Hear 2018 Oct 17. Epub 2018 Oct 17.

Service ORL, CHU Toulouse, Toulouse, France.

Objective: Normal-hearing subjects listening to acoustic simulations of cochlear implants (CI) can obtain sentence recognition scores near 100% in quiet and in 10 dB signal-to-noise ratio (SNR) noise with acute exposure. However, average sentence recognition scores for real CI listeners are generally lower, even after months of experience, and there is a high degree of heterogeneity. Our aim was to identify the relative importance and strength of factors that prevent CI listeners from achieving early, 1-mo scores as high as those for normal-hearing-listener acoustic simulations. Read More

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October 2018
9 Reads