314 results match your criteria OBG Management [Journal]


Cellular roles of the human Obg-like ATPase 1 (hOLA1) and its bacterial homologue, YchF.

Biochem Cell Biol 2019 Feb 11. Epub 2019 Feb 11.

University of Lethbridge, 4512, Faculty of Arts and Science, Biochemistry , 4401 University Drive , Lethbridge, Alberta, Canada , T1K 3M4 ;

P-loop NTPases comprise one of the major superfamilies of nucleotide binding proteins, which mediate a variety of cellular processes, such as mRNA translation, signal transduction, cell motility, and growth regulation. In this review, we discuss the structure and function of two-members of the ancient Obg-related family of P-loop GTPases: human obg-like ATPase 1 (hOLA1) and its bacterial homolog, YchF. After a brief discussion of nucleotide binding proteins in general and the classification of the Obg-related family in particular, we discuss the sequence and structural features of YchF and hOLA1. Read More

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http://dx.doi.org/10.1139/bcb-2018-0353DOI Listing
February 2019

Health-Promoting Behaviors and Menopausal Symptoms: An Interventional Study in Rural India.

J Midlife Health 2018 Oct-Dec;9(4):200-206

Department of OBG Nursing, MM College of Nursing, Ambala, Haryana, India.

Background: Menopausal transition initiates with menstrual cycle length variety and finishes when last menstrual period happens. As life expectancy has increased, a menopausal woman has to spend one-third of her life span with estrogen deprivation stage that leads to major long-term symptomatic and metabolic complications.

Methods: This was a quasi-experimental study conducted on 103 menopausal women between 40 and 60 years of age residing in Ambala district, Haryana. Read More

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http://www.jmidlifehealth.org/text.asp?2018/9/4/200/249155
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http://dx.doi.org/10.4103/jmh.JMH_96_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332721PMC
January 2019
3 Reads

Assessment of Symptoms and Quality of Life among Postmenopausal Women in a Tertiary Care Hospital in Kochi, South India: A Hospital-based Descriptive Study.

J Midlife Health 2018 Oct-Dec;9(4):185-190

Department of Community Medicine, Pondicherry Institute of Medical Sciences, Kalapet, Puducherry, India.

Background: Menopause is a physiological event in the women's life that can strongly affect the quality of life (QOL). More than 80% of women state that physical and physiological symptoms commonly accompany menopause and affect women's health and well-being.

Objective: The aim of the study was to assess the menopause-related symptoms and their impact on the women's life. Read More

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http://www.jmidlifehealth.org/text.asp?2018/9/4/185/249156
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http://dx.doi.org/10.4103/jmh.JMH_98_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332724PMC
January 2019
4 Reads

Physical Fitness and Body Composition in 10-12-Year-Old Danish Children in Relation to Leisure-Time Club-Based Sporting Activities.

Biomed Res Int 2018 27;2018:9807569. Epub 2018 Dec 27.

Department of Sports Science and Clinical Biomechanics, SDU Sport and Health Sciences Cluster (SHSC), University of Southern Denmark, Odense, Denmark.

This study investigated whether the physical fitness and body composition of 10-12-year-old Danish children are related to participation in leisure-time club-based sporting activities. The study involved 544 Danish 10-12-year-old 5th-grade municipal schoolchildren (269 boys and 275 girls, 11.1 ± 0. Read More

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http://dx.doi.org/10.1155/2018/9807569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327252PMC
December 2018
1 Read

RACK1 regulates centriole duplication by controlling localization of BRCA1 to the centrosome in mammary tissue-derived cells.

Oncogene 2019 Jan 7. Epub 2019 Jan 7.

Department of Cancer Biology, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.

Breast cancer gene 1 (BRCA1) is a tumor suppressor that is associated with hereditary breast and ovarian cancer. BRCA1 functions in DNA repair and centrosome regulation together with BRCA1-associated RING domain protein (BARD1), a heterodimer partner of BRCA1. Obg-like ATPase 1 (OLA1) was identified as a protein that interacts with BARD1. Read More

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http://dx.doi.org/10.1038/s41388-018-0647-8DOI Listing
January 2019
1 Read

Metabolic Changes Induced by High-Fat Meal Evoke Different Microvascular Responses in Accordance with Adiposity Status.

Biomed Res Int 2018 1;2018:5046508. Epub 2018 Nov 1.

Laboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ 20550-013, Brazil.

Background: Frequently, ingestion of lipids exceeds our daily requirements and constantly exposes humans to circulating lipid overload which may lead to endothelial dysfunction (ED), the earliest marker of atherosclerosis. Nailfold videocapillaroscopy (NVC) technique can detect ED on microcirculation. Using NVC, we aimed to demonstrate if metabolic alterations evoked by high-fat meals can act differently on microvascular endothelial reactivity in lean and women with obesity. Read More

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http://dx.doi.org/10.1155/2018/5046508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236900PMC
November 2018
2 Reads

Application of different laboratory techniques to monitor the behaviour of a Mycoplasma synoviae vaccine (MS-H) in broiler breeders.

BMC Vet Res 2018 Nov 20;14(1):357. Epub 2018 Nov 20.

Avian Medicine Laboratory Mycoplasma Unit - SCT1, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, 35020. Legnaro, Padova, Italy.

Background: Mycoplasma synoviae (MS) is a major poultry pathogen which causes severe economic losses in all the productive sectors. The prevalence of MS in European countries has increased in the last few years, leading to greater attention to the available methods to prevent its spread. The main strategy currently applied for its containment is the development and maintenance of MS-free breeder flocks. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1669-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245925PMC
November 2018
6 Reads

Structural modules of the stress-induced protein HflX: an outlook on its evolution and biological role.

Curr Genet 2018 Nov 17. Epub 2018 Nov 17.

Structural Biology and Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata, 700 032, India.

Multifunctional proteins often show modular structures. A functional domain and the structural modules within the domain show evolutionary conservation of their spatial arrangement since that gives the protein its functionality. However, the question remains as to how members of different domains of life (Archaea, Bacteria, Eukarya), polish and perfect these modules within conserved multidomain proteins, to tailor functional proteins according to their specific requirements. Read More

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http://link.springer.com/10.1007/s00294-018-0905-x
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http://dx.doi.org/10.1007/s00294-018-0905-xDOI Listing
November 2018
7 Reads

Human GTPBP10 is required for mitoribosome maturation.

Nucleic Acids Res 2018 Nov;46(21):11423-11437

Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Most steps on the biogenesis of the mitochondrial ribosome (mitoribosome) occur near the mitochondrial DNA nucleoid, in RNA granules, which contain dedicated RNA metabolism and mitoribosome assembly factors. Here, analysis of the RNA granule proteome identified the presence of a set of small GTPases that belong to conserved families of ribosome assembly factors. We show that GTPBP10, a member of the conserved Obg family of P-loop small G proteins, is a mitochondrial protein and have used gene-editing technologies to create a HEK293T cell line KO for GTPBP10. Read More

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
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http://dx.doi.org/10.1093/nar/gky938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265488PMC
November 2018
8 Reads

A randomized comparative study of herbal decoction of Cassia fistula Linn pod's pericarp and Myristica fragrans Houtt arils vs. mefenamic acid in spasmodic dysmenorrhoea.

J Complement Integr Med 2018 Oct 12. Epub 2018 Oct 12.

Dept of Ilmul Qabalat wa Amraze Niswan (OBG), National Institute of Unani Medicine, Bengaluru, India.

Background To compare the efficacy and safety of herbal decoction (pods of Cassia fistula Linn. and Arils of Myristica fragrans Houtt) with mefenamic acid in spasmodic dysmenorrhoea. Methods In this single-blind, prospective, parallel, standard controlled study, dysmenorrheic patients (n=64) were randomly allocated to receive herbal decoction (n=31) or mefenamic acid (n=33) for two consecutive menstrual cycles. Read More

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http://dx.doi.org/10.1515/jcim-2018-0105DOI Listing
October 2018
19 Reads

Prenatal Yoga: Effects on Alleviation of Labor Pain and Birth Outcomes.

J Altern Complement Med 2018 Aug 30. Epub 2018 Aug 30.

2 Department of OBG, Lady Hardinge Medical College , New Delhi, India .

Background: This study was conducted to test the hypothesis that prenatal yogic exercises are effective in alleviating labor pain and improving birth outcomes, by comparing pregnant women undertaking yoga with a control group.

Trial Design: Single blinded, parallel randomized control trial.

Methods: Two hundred primigravid women of 30 weeks of gestation onward who met the inclusion criteria (primigravida, 20-35 years of age, gestational age of 30 weeks, no prior experience of yoga) were randomly assigned to study (n = 100) and control groups (n = 100) by using the minimized randomization program version 2. Read More

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http://dx.doi.org/10.1089/acm.2018.0079DOI Listing
August 2018
12 Reads

The Persistence-Inducing Toxin HokB Forms Dynamic Pores That Cause ATP Leakage.

MBio 2018 08 14;9(4). Epub 2018 Aug 14.

Center for Microbiology, VIB, Leuven, Belgium

Bacterial populations harbor a small fraction of cells that display transient multidrug tolerance. These so-called persister cells are extremely difficult to eradicate and contribute to the recalcitrance of chronic infections. Several signaling pathways leading to persistence have been identified. Read More

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http://dx.doi.org/10.1128/mBio.00744-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094483PMC

Geometric morphometric analysis of the palatal morphology in growing subjects with skeletal open bite.

Eur J Orthod 2018 Aug 9. Epub 2018 Aug 9.

Department of Orthodontics, University of Rome 'Tor Vergata', Rome, Italy.

Objectives: To assess the morphological shape variations of the palatal vault in Open Bite (OB) growing subjects when compared with a Control Group (CG) by means of Geometric Morphometric Method (GMM).

Materials And Methods: The OB Group (OBG) consisted of 75 subjects (39 females, 36 males; mean age: 8.5 ± 0. Read More

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http://dx.doi.org/10.1093/ejo/cjy055DOI Listing
August 2018
12 Reads

Fellow Perceptions of Residency Training in Obstetrics and Gynecology.

J Surg Educ 2019 Jan - Feb;76(1):93-98. Epub 2018 Aug 7.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, Colorado.

Objective: To evaluate the perceptions of current and former fellows in obstetrics and gynecology (OBG) subspecialties of their readiness for fellowship training.

Methods: A previously used survey was modified and distributed in 2016 to current and former fellows in gynecologic oncology, maternal-fetal medicine, reproductive endocrinology-infertility, and female pelvic medicine and reconstructive surgery. The survey explored domains of professionalism, independent practice, psychomotor ability, clinical evaluation, and scholarship. Read More

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http://dx.doi.org/10.1016/j.jsurg.2018.06.013DOI Listing
August 2018
4 Reads

The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.

Nucleic Acids Res 2018 Sep;46(16):8471-8482

Department of Cellular Biochemistry, University Medical Center Göttingen, D-37073 Göttingen, Germany.

The human mitochondrial translation apparatus, which synthesizes the core subunits of the oxidative phosphorylation system, is of central interest as mutations in several genes encoding for mitoribosomal proteins or translation factors cause severe human diseases. Little is known, how this complex machinery assembles from nuclear-encoded protein components and mitochondrial-encoded RNAs, and which ancillary factors are required to form a functional mitoribosome. We have characterized the human Obg protein GTPBP10, which associates specifically with the mitoribosomal large subunit at a late maturation state. Read More

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http://dx.doi.org/10.1093/nar/gky701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144781PMC
September 2018
1 Read

Outcomes after bone grafting in patients with and without ACL revision surgery: a retrospective study.

BMC Musculoskelet Disord 2018 Jul 21;19(1):246. Epub 2018 Jul 21.

Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, TU Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Background: Current literature is lacking of data regarding functional outcomes in patients following bone tunnel grafting with or without revision anterior cruciate ligament (ACL) reconstruction. Therefore, the aim of the present study was to evaluate the clinical outcome in patients with (RACL) or without revision ACL reconstruction (OBG) following bone grafting.

Methods: Fifty-nine patients (18 female, 41 male) who underwent bone grafting due to recurrent, symptomatic ACL deficiency following ACL reconstruction between 2011 and 2014 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s12891-018-2174-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054851PMC
July 2018
3 Reads

BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number.

Mol Cancer Res 2018 Oct 1;16(10):1499-1511. Epub 2018 Jun 1.

Department of Cancer Biology, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.

BRCA1 functions as a tumor suppressor in DNA repair and centrosome regulation. Previously, Obg-like ATPase 1 (OLA1) was shown to interact with BARD1, a heterodimer partner of BRCA1. OLA1 binds to BRCA1, BARD1, and γ-tubulin and functions in centrosome regulation. Read More

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0269DOI Listing
October 2018
1 Read

PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma.

Oncotarget 2018 May 8;9(35):23923-23943. Epub 2018 May 8.

Department of Neurosurgery, Kenneth R. Peak Brain and Pituitary Tumor Center, Houston Methodist Hospital, TX 77030, Houston, USA.

Via extensive analyses of genetic databases, we have characterized the DNA-repair capacity of glioblastoma with respect to patient survival. In addition to elevation of O-methylguanine DNA methyltransferase (MGMT), down-regulation of three DNA repair pathways; canonical mismatch repair (MMR), Non-Homologous End-Joining (NHEJ), and Homologous Recombination (HR) are correlated with poor patient outcome. We have designed and tested both and , a monoamine oxidase B (MAOB) specific prodrug, PAM-OBG, that is converted by glioma MAOB into the MGMT inhibitor O-benzylguanine (OBG) and the DNA crosslinking agent acrolein. Read More

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http://dx.doi.org/10.18632/oncotarget.25246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963626PMC
May 2018
1 Read

Immunohistochemistry for mismatch repair protein deficiency in endometrioid endometrial carcinoma yields equivalent results when performed on endometrial biopsy/curettage or hysterectomy specimens.

Gynecol Oncol 2018 06 13;149(3):570-574. Epub 2018 Apr 13.

Department of Pathology, University of Chicago, 5841 S. Maryland Ave, Chicago, Illinois, USA. Electronic address:

Objective: Universal screening of endometrial cancer (EC) for Lynch syndrome (LS) has been increasingly implemented in the past five to ten years. Most pathologists initiate screening with immunohistochemistry (IHC) for mismatch repair proteins (MMRPs), using either pre-surgical samplings (endometrial biopsy or curettage, EMB/C) or hysterectomy specimens. We report a systematic assessment of the equivalence of IHC for LS screening on EMB/C versus hysterectomy specimens. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.04.005DOI Listing
June 2018
5 Reads

Characterization of mitochondrion-targeted GTPases in Plasmodium falciparum.

Parasitology 2018 Oct 12;145(12):1600-1612. Epub 2018 Apr 12.

Division of Molecular and Structural Biology,CSIR-Central Drug Research Institute,Lucknow,India.

Ribosome assembly is critical for translation and regulating the response to cellular events and requires a complex interplay of ribosomal RNA and proteins with assembly factors. We investigated putative participants in the biogenesis of the reduced organellar ribosomes of Plasmodium falciparum and identified homologues of two assembly GTPases - EngA and Obg that were found in mitochondria. Both are indispensable in bacteria and P. Read More

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http://dx.doi.org/10.1017/S0031182018000501DOI Listing
October 2018
6 Reads

Complementation of the Mycoplasma synoviae MS-H vaccine strain with wild-type obg influencing its growth characteristics.

PLoS One 2018 28;13(3):e0194528. Epub 2018 Mar 28.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, Victoria, Australia.

The temperature-sensitive (ts+) Mycoplasma synoviae vaccine strain MS-H harbors a non-synonymous mutation which results in Glycine to Arginine substitution at position 123 in the highly conserved glycine-rich motif of Obg-fold in the GTP-binding protein Obg. In-silico analysis of the wild-type and mutant Obgs of M. synoviae has indicated that this amino acid substitution affects structure of the protein, potentially leading to abrogation of Obg function in vivo. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194528PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874028PMC
July 2018
5 Reads

Effect of adding oat bran to instant oatmeal on glycaemic response in humans - a study to establish the minimum effective dose of oat β-glucan.

Food Funct 2018 Mar 26;9(3):1692-1700. Epub 2018 Feb 26.

DSM Nutritional Products Ltd., R&D Human Nutrition and Health, Basel, Switzerland and Department of Surgery, Division of Visceral and Transplantation Surgery, University Hospital Zürich, Zürich, Switzerland.

Reducing the glycaemic response to carbohydrate-containing foods may have desirable physiological effects for many people. Here, we aimed to determine the minimum amount of oat β-glucan from oat-bran which, when added to instant-oatmeal, would reduce the glycaemic response by 20% compared to a β-glucan-free cereal. Therefore, the glycaemic responses elicited by one serving (27 g) instant-oatmeal plus 247 g 2% milk (IO, 28 g available-carbohydrate, 1. Read More

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http://dx.doi.org/10.1039/c7fo01768eDOI Listing
March 2018
6 Reads

Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect.

Sci Rep 2018 02 2;8(1):2305. Epub 2018 Feb 2.

Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Miyagi, 980-8578, Japan.

Ouabagenin (OBG) is an aglycone of the cardiotonic steroid ouabain and until now was considered a biologically inactive biosynthetic precursor. Herein, we revealed that OBG functions as a novel class of ligand for the liver X receptor (LXR). Luciferase reporter assays and in silico docking studies suggested that OBG has LXR-selective agonistic activity. Read More

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http://dx.doi.org/10.1038/s41598-018-20663-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797171PMC
February 2018
1 Read

Rice Encoding Obg-Like GTPase Protein Is Essential for Chloroplast Development During the Early Leaf Stage Under Cold Stress.

G3 (Bethesda) 2018 01 4;8(1):253-263. Epub 2018 Jan 4.

Development Center of Plant Germplasm Resources, College of Life and Environment Sciences, Shanghai Normal University, 200234, China

The Spo0B-associated GTP-binding (Obg) proteins are essential for the viability of nearly all bacteria. However, the detailed roles of Obg proteins in higher plants have not yet been elucidated. In this study, we identified a novel rice ( L. Read More

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http://dx.doi.org/10.1534/g3.117.300249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765353PMC
January 2018
9 Reads

Characterization of an Olive Flounder Bone Gelatin-Zinc Oxide Nanocomposite Film and Evaluation of Its Potential Application in Spinach Packaging.

J Food Sci 2017 Nov 17;82(11):2643-2649. Epub 2017 Oct 17.

Dept. of Food Science and Technology, Chungnam National Univ., Daejeon 34134, Republic of Korea.

Olive flounder bone gelatin (OBG) was used for a film base material in this study. In addition, zinc oxide nanoparticles (ZnO) were incorporated into the OBG film to prepare a nanocomposite film and to impart antimicrobial activity to it. The tensile strength of the OBG film increased by 6. Read More

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http://dx.doi.org/10.1111/1750-3841.13949DOI Listing
November 2017
3 Reads

Towards a taxonomy of topology for polynuclear aromatic hydrocarbons: linking electronic and molecular structure.

Phys Chem Chem Phys 2017 Oct;19(41):28458-28469

Department of Chemistry George Washington University 800 22nd St, NW Suite 4000, Washington, DC 20052, USA.

Trends linking the topological characteristics of polynuclear aromatic hydrocarbons (PAH) to their electronic properties are reported. TD-DFT electronic spectra computations, using the 6-31G* basis set and B3LYP exchange correlation functional, were calculated for a series of PAH, allowing for the HOMO-LUMO gaps to be reported. Clar structures provide an avenue to link the physical structure and the aromaticity of the molecule; which, when extended by bond length and harmonic oscillator model of aromaticity analysis, provide powerful tools to understand the link between electronic and physical structure. Read More

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http://dx.doi.org/10.1039/c7cp06048cDOI Listing
October 2017
9 Reads

Outcome of colon cancer initially presenting as colon perforation and obstruction.

World J Surg Oncol 2017 Aug 25;15(1):164. Epub 2017 Aug 25.

Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.

Background: Emergency complications of colon cancer include perforation and obstruction which were recognized as poor prognostic factors. Few studies have directly compared the outcomes of these two groups. In this study, we evaluated mortality and morbidity in patients with colon cancer initially presenting as perforation and obstruction. Read More

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http://dx.doi.org/10.1186/s12957-017-1228-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574146PMC
August 2017
16 Reads

Assessment of Sperm Deoxyribose Nucleic Acid Fragmentation Using Sperm Chromatin Dispersion Assay.

J Pharmacol Pharmacother 2017 Apr-Jun;8(2):45-49

Department of Anatomy, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

The integrity of sperm deoxyribose nucleic acid (DNA) is one of the determinants that ensure normal fertilization, implantation, pregnancy, and the generation of a healthy progeny. Assessment of sperm DNA fragmentation has gained importance as a tool to provide significant information regarding sperm quality, and it can independently predict sperm fertilizing potential. The sperm chromatin dispersion (SCD) assay is one of the available techniques to detect sperm DNA damage with results comparable to the gold standard - Sperm Chromatin Structure Assay. Read More

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http://dx.doi.org/10.4103/jpp.JPP_187_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497398PMC
July 2017
3 Reads

A Mutant Isoform of ObgE Causes Cell Death by Interfering with Cell Division.

Front Microbiol 2017 28;8:1193. Epub 2017 Jun 28.

Centre of Microbial and Plant Genetics, KU Leuven - University of LeuvenLeuven, Belgium.

Cell division is a vital part of the cell cycle that is fundamental to all life. Despite decades of intense investigation, this process is still incompletely understood. Previously, the essential GTPase ObgE, which plays a role in a myriad of basic cellular processes (such as initiation of DNA replication, chromosome segregation, and ribosome assembly), was proposed to act as a cell cycle checkpoint in by licensing chromosome segregation. Read More

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http://journal.frontiersin.org/article/10.3389/fmicb.2017.01
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http://dx.doi.org/10.3389/fmicb.2017.01193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487468PMC
June 2017
31 Reads

Correlation of Serum Vitamin D Level with Mortality in Patients with Sepsis.

Indian J Crit Care Med 2017 Apr;21(4):199-204

Department of Medicine, King George's Medical College, Lucknow, Uttar Pradesh, India.

Background: Sepsis is the leading cause of mortality in the critically ill. Recently, it has been found in many studies that many trace elements and nutrients do have an effect on human body and if supplemented can improve the prognosis in patients with sepsis.

Aim And Objectives: Primary objective: Whether low Vitamin D is associated with mortality. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_192_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416786PMC
April 2017
3 Reads

Structural insights of Mycobacterium GTPase-Obg and anti-sigma-F factor Usfx interaction.

J Mol Recognit 2017 10 4;30(10). Epub 2017 May 4.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

An essential protein for bacterial growth, GTPase-Obg (Obg), is known to play an unknown but crucial role in stress response as its expression increases in Mycobacterium under stress conditions. It is well reported that Obg interacts with anti-sigma-F factor Usfx; however, a detailed analysis and structural characterization of their physical interaction remain undone. In view of above-mentioned points, this study was conceptualized for performing binding analysis and structural characterization of Obg-Usfx interaction. Read More

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http://dx.doi.org/10.1002/jmr.2636DOI Listing
October 2017
8 Reads

Screening methods (clinical breast examination and mammography) to detect breast cancer in women aged 40-49 years.

J Midlife Health 2017 Jan-Mar;8(1):2-10

Department of Pathology, GMCH, Chandigarh, India.

Objective: The aim of this study is to detect breast cancer rate, nodal status, tumor size, and associated risk factors using clinical breast examination (CBE) and mammography as screening tools in women aged 40-49 years.

Materials And Methods: A total of 500 women were screened in a time period of 2 years, between the ages of 40-49 years for breast cancer. Screening tools used were CBE and mammography. Read More

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http://dx.doi.org/10.4103/jmh.JMH_26_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367219PMC
May 2017
12 Reads

The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death.

Microb Cell 2016 Mar 16;3(6):255-256. Epub 2016 Mar 16.

Centre of Microbial and Plant Genetics, KU Leuven - University of Leuven, 3001 Leuven, Belgium.

The phenomenon of programmed cell death (PCD), in which cells initiate their own demise, is not restricted to multicellular organisms. Unicellular organisms, both eukaryotes and prokaryotes, also possess pathways that mediate PCD. We recently identified a PCD mechanism in that is triggered by a mutant isoform of the essential GTPase ObgE (Obg of ). Read More

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http://dx.doi.org/10.15698/mic2016.06.507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348993PMC
March 2016
7 Reads

Vertical Ridge Augmentation in the Atrophic Mandible: A Systematic Review and Meta-Analysis.

Int J Oral Maxillofac Implants 2017 Mar/Apr;32(2):291-312

Purpose: To systematically appraise the effectiveness/reliability of vertical ridge augmentation (VRA) in the atrophic mandible. Articles that addressed any one of the following four areas were included in this study: amount of VRA, implant survival (ISR) and success rates (SSR) in the area of newly regenerated bone, complication rate during the bone augmentation procedure, and bone resorption.

Materials And Methods: An electronic literature search was conducted by two independent reviewers in several databases, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register databases for articles reporting VRA in the atrophic mandible via distraction osteogenesis (DO), inlay block grafting (IBG), onlay block grafting (OBG), and guided bone regeneration (GBR). Read More

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http://dx.doi.org/10.11607/jomi.4861DOI Listing
June 2017
7 Reads

Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E mice.

Microbiome 2017 03 13;5(1):30. Epub 2017 Mar 13.

Department of Food Biosciences, Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland.

Background: There is strong evidence indicating that gut microbiota have the potential to modify, or be modified by the drugs and nutritional interventions that we rely upon. This study aims to characterize the compositional and functional effects of several nutritional, neutraceutical, and pharmaceutical cardiovascular disease interventions on the gut microbiome, through metagenomic and metabolomic approaches. Apolipoprotein-E-deficient mice were fed for 24 weeks either high-fat/cholesterol diet alone (control, HFC) or high-fat/cholesterol in conjunction with one of three dietary interventions, as follows: plant sterol ester (PSE), oat β-glucan (OBG) and bile salt hydrolase-active Lactobacillus reuteri APC 2587 (BSH), or the drug atorvastatin (STAT). Read More

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http://dx.doi.org/10.1186/s40168-017-0246-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346842PMC
March 2017
17 Reads

Development, validation and field evaluation of a quantitative real-time PCR able to differentiate between field Mycoplasma synoviae and the MS-H-live vaccine strain.

Avian Pathol 2017 Aug 20;46(4):403-415. Epub 2017 Apr 20.

a GD-Animal Health Service , Deventer , the Netherlands.

A quantitative PCR (qPCR) able to differentiate between field Mycoplasma synoviae and MS-H vaccine strain was developed, validated and evaluated. It was developed using nucleotide differences in the obg gene. Analytical specificity and sensitivity assessed using DNA from 194 M. Read More

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http://dx.doi.org/10.1080/03079457.2017.1296105DOI Listing
August 2017
4 Reads

Molluscum Contagiosum of Cervix - A Case Report.

J Clin Diagn Res 2017 Jan 1;11(1):ED03-ED04. Epub 2017 Jan 1.

Professor, Department of Medicine, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka. India .

Molluscum Contagiosum (MC) is a common viral infection of skin caused by a double stranded DNA Pox virus affecting both adults and children. MC is primarily an infection of school-going children (one to five years), occasionally it affects adults and immunocompromised individuals. Transmission of virus occurs by direct contact with infected persons or contaminated objects. Read More

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http://dx.doi.org/10.7860/JCDR/2017/24545.9186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324420PMC
January 2017
3 Reads

Over-the-counter MTP Pills and Its Impact on Women's Health.

J Obstet Gynaecol India 2017 Feb 25;67(1):37-41. Epub 2016 Jun 25.

Department of OBG, BMCRI, No. 617, B4, Sharavathi Block, National Games Village, Koramangala, Bangalore, 560047 India.

Objectives: To study the complications and consequences including maternal morbidity and mortality following indiscriminate self-consumption of abortion pills reporting to a tertiary care center.

Methodology: This is an observational study conducted at Vanivilas hospital between January 2012 to December 2013 for 24 months. After applying inclusion and exclusion criteria, 104 women were studied with respect to period of gestation, parity, clinical features at presentation and management in the institution. Read More

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http://dx.doi.org/10.1007/s13224-016-0916-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306099PMC
February 2017
21 Reads

Structural and biochemical analysis of ObgE, a central regulator of bacterial persistence.

J Biol Chem 2017 04 21;292(14):5871-5883. Epub 2017 Feb 21.

From the Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels,

The Obg protein family belongs to the TRAFAC (translation factor) class of P-loop GTPases and is conserved from bacteria to eukaryotes. Essential roles in many different cellular processes have been suggested for the Obg protein from (ObgE), and we recently showed that it is a central regulator of bacterial persistence. Here, we report the first crystal structure of ObgE at 1. Read More

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http://dx.doi.org/10.1074/jbc.M116.761809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392579PMC
April 2017
13 Reads

Alveolar Ridge Splitting Versus Autogenous Onlay Bone Grafting: Complications and Implant Survival Rates.

Implant Dent 2017 Apr;26(2):284-287

*Assistant Professor, Department of Oral and Maxillofacial Surgery, Baskent University, Ankara, Turkey. †Assistant Professor, Department of Oral and Maxillofacial Surgery, Baskent University, Ankara, Turkey. ‡Assistant Professor, Department of Oral and Maxillofacial Surgery, Medipol University, Istanbul, Turkey. §Professor, Department of Oral and Maxillofacial Surgery, Medipol University, Istanbul, Turkey.

Purpose: To compare the complications and implant survival rates of localized alveolar ridge deficiencies in the horizontal dimension reconstructed by alveolar ridge splitting (ARS) or autogenous onlay bone grafting (OBG).

Materials And Methods: Twenty-eight ARS and 28 OBG were performed. The survival rate of the all included implants was evaluated using the clinical and radiographical evaluation criteria of Misch et al. Read More

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http://Insights.ovid.com/crossref?an=00008505-201704000-0001
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http://dx.doi.org/10.1097/ID.0000000000000541DOI Listing
April 2017
2 Reads

Unicornuate Uterus with a Functional Non-communicating Horn in a Parous Woman.

J Obstet Gynaecol India 2016 10 14;66(Suppl 2):604-606. Epub 2016 Mar 14.

Department of OBG, Manipal Hospital, Bangalore, India.

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http://dx.doi.org/10.1007/s13224-016-0855-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080250PMC
October 2016

Successful myomectomy in early pregnancy for a large asymptomatic uterine myoma: case report.

Pan Afr Med J 2016 13;24:228. Epub 2016 Jul 13.

Department of Radiology Regional Hospital Reckong Peo Kinnaur, HP, India.

The decision of myomectomy is not usually taken by OBG specialist for uterine fibroids during pregnancy because of its complications which may become hazardous at times. This is why it is generally delayed until after delivery. The current case was a large, asymptomatic subserous uterine myoma diagnosed during pregnancy by ultrasound and successfully managed by antepartum myomectomy retaining the fetus alive in utero at 13 -14 weeks gestation. Read More

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http://dx.doi.org/10.11604/pamj.2016.24.228.9890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075483PMC
February 2017
4 Reads

Identification and Characterization of a Chloroplast-Targeted Obg GTPase in Dendrobium officinale.

DNA Cell Biol 2016 Dec 6;35(12):802-811. Epub 2016 Oct 6.

2 Institute for New Rural Development, Sichuan Agricultural University , Yaan, China .

Bacterial homologous chloroplast-targeted Obg GTPases (ObgCs) belong to the plant-typical Obg group, which is involved in diverse physiological processes during chloroplast development. However, the evolutionarily conserved function of ObgC in plants remains elusive and requires further investigation. In this study, we identified DoObgC from an epiphytic plant Dendrobium officinale and demonstrated the characteristics of DoObgC. Read More

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http://dx.doi.org/10.1089/dna.2016.3413DOI Listing
December 2016
9 Reads

Searching new targets to counter drug resistance - GTPase-Obg mRNA expression analysis in Mycobacterium under stress and in silico docking with GTPase inhibitors.

J Biomol Struct Dyn 2017 06 12;35(8):1804-1812. Epub 2016 Aug 12.

a Department of Biophysics , All India Institute of Medical Sciences , New Delhi 110029 , India.

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http://dx.doi.org/10.1080/07391102.2016.1195284DOI Listing
June 2017
8 Reads

Intrinsic GTPase activity of a ribosomal maturation protein CgtA is associated with its inter-domain movement: insights from MD simulations and biochemical studies.

J Biomol Struct Dyn 2017 Sep 28;35(12):2578-2587. Epub 2016 Sep 28.

a Department of Biological Sciences , Indian Institute of Science Education and Research-Kolkata , Mohanpur, Nadia , West Bengal 741246 , India.

CgtA is an essential ribosome associated GTPase protein of bacteria. It has three domains, viz., Obg, GTPase, and C-terminal domain. Read More

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http://dx.doi.org/10.1080/07391102.2016.1224732DOI Listing
September 2017

Hypothesis: type I toxin-antitoxin genes enter the persistence field-a feedback mechanism explaining membrane homoeostasis.

Authors:
Kenn Gerdes

Philos Trans R Soc Lond B Biol Sci 2016 11;371(1707)

Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark

Bacteria form persisters, cells that are tolerant to multiple antibiotics and other types of environmental stress. Persister formation can be induced either stochastically in single cells of a growing bacterial ensemble, or by environmental stresses, such as nutrient starvation, in a subpopulation of cells. In many cases, the molecular mechanisms underlying persistence are still unknown. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052752PMC
http://dx.doi.org/10.1098/rstb.2016.0189DOI Listing
November 2016
14 Reads

Litigations in Obstetric and Gynecological Practice: Can it be prevented? A Probability to Possibility.

J Obstet Gynaecol India 2016 Oct 16;66(Suppl 1):541-7. Epub 2016 Apr 16.

Department of OBG, JSS Medical College and Hospital, JSS University, #140/4, 2nd Cross, Shankarmutt Road, Fort Mohalla, Mysore, Karnataka 570004 India.

Background: Litigation in medical practice is becoming a global problem. So it is necessary to know what constitutes negligence and what is required to prove it and how far it is preventable.

Objectives: To analyze the prevalence and reasons for litigations in Obstetrics and Gynaecology for medical negligence and deficiency in service. Read More

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http://dx.doi.org/10.1007/s13224-016-0881-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016466PMC
October 2016
2 Reads

Non-decent Vaginal Hysterectomy in Rural Setup of MP: A Poor Acceptance.

J Obstet Gynaecol India 2016 Oct 12;66(Suppl 1):499-504. Epub 2016 Mar 12.

Department of OBG, L.N. Medical College and J.K. Hospital, Kolar Road, Bhopal, 462042 M.P India.

Objective: NDVH is a minimally invasive, safe, effective, and economical surgery. Still AH is preferred for benign gynaecological indications. Our study aims to promote NDVH in all technically possible cases by adequate counselling of the patient. Read More

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http://dx.doi.org/10.1007/s13224-016-0858-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016454PMC
October 2016
1 Read

Hysterolaparoscopy in the Evaluation and Management of Female Infertility.

Authors:
Y M Kabadi B Harsha

J Obstet Gynaecol India 2016 Oct 11;66(Suppl 1):478-81. Epub 2016 Mar 11.

Department of OBG, Karnataka Institute of Medical Sciences (KIMS), Room No 92, Vivek Hostel, KIMS Campus, Vidyanagara, Hubli, Karnataka 580021 India.

Objective: To study the role of hysterolaparoscopy in the evaluation and management of female infertility.

Materials And Methods: A retrospective study of the 94 case files of all the patients who underwent diagnostic hysterolaparoscopy for infertility between January 2014 to June 2015 in the department of Obstetrics and Gynecology, Karnataka Institute of Medical Sciences, Hubli. These infertile women were confirmed to have normal ovulatory cycles, hormonal assays and seminogram report. Read More

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http://dx.doi.org/10.1007/s13224-016-0863-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016458PMC
October 2016
3 Reads

Role of Tranexamic Acid in Reducing Blood Loss in Vaginal Delivery.

J Obstet Gynaecol India 2016 Oct 31;66(Suppl 1):246-50. Epub 2016 Mar 31.

Department of Obstetrics and Gynaecology, King's Mill Hospital, Sutton in Ashfield, Nottinghamshire UK.

Introduction: Anti-fibrinolytic agents are used to reduce obstetric blood loss as the fibrinolytic system is known to get activated after placental delivery.

Objectives: To evaluate the efficacy of parenteral tranexamic acid in reducing blood loss during normal labour and to compare it with the amount of blood loss in patients who received placebo in the third stage of labour.

Methodology: Patients with spontaneous labour or planned for induction of labour and fulfilling the inclusion criteria were recruited for the study. Read More

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http://link.springer.com/10.1007/s13224-016-0856-4
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http://dx.doi.org/10.1007/s13224-016-0856-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016452PMC
October 2016
6 Reads