250,233 results match your criteria Nutritional Therapy and Metabolism [Journal]


Periconceptional intake of folic acid among low-risk women in Canada: summary of a workshop aiming to align prenatal folic acid supplement composition with current expert guidelines.

Am J Clin Nutr 2018 Dec;108(6):1357-1368

School of Nutrition Sciences, University of Ottawa, Ottawa, Ontario, Canada.

The Government of Canada and the Society of Obstetricians and Gynaecologists of Canada both recommend a daily multivitamin supplement containing 400 µg folic acid (FA) for the primary prevention of neural tube defects among low-risk women from before conception and throughout lactation. Prenatal supplements marketed and prescribed in Canada typically exceed the recommended dose, usually providing ≥1000 µg FA/d. This high daily dose, coupled with staple-food FA fortification, has resulted in the observation of very high blood folate concentrations among reproductive-aged women consuming FA-containing supplements. Read More

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December 2018

Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review.

Am J Clin Nutr 2018 Dec;108(6):1196-1208

Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.

Background: There is great overlap between the presentation of cachexia, sarcopenia, and malnutrition. Distinguishing between these conditions would allow for better targeted treatment for patients.

Objectives: The aim was to systematically review validated screening tools for cachexia, sarcopenia, and malnutrition in adults and, if a combined tool is absent, make suggestions for the generation of a novel screening tool. Read More

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December 2018
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Factors that can influence the survival rates of coral snakes (Micrurus corallinus) for antivenom production.

J Anim Sci 2018 Dec 12. Epub 2018 Dec 12.

Laboratório de Herpetologia do Instituto Butantan, Av. Vital Brazil, São Paulo - Brasil.

Envenoming and deaths resulting from snakebites are a particularly important public health problem in rural tropical areas of Africa, Asia, Latin America and New Guinea. In 2015 The Lancet highlighted snake-bite envenoming as a neglected tropical disease and urged the world to increase antivenom production. In Brazil around 20,000 snakebites occur per year affecting mostly agricultural workers and children, of which 1% are caused by coral snakes (Micrurus sp). Read More

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December 2018

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis.

Int J Epidemiol 2018 Dec 11. Epub 2018 Dec 11.

Population Health Sciences, University of Bristol, Bristol, UK.

Background: Accumulating evidence suggests that breastfeeding benefits children's intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, an interaction between breastfeeding and genetic variants associated with endogenous LC-PUFAs synthesis might be expected. However, the literature on this topic is controversial. Read More

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December 2018
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Influence of Nutritional Management and Rehabilitation on Physical Outcome in Japanese Intensive Care Unit Patients: A Multicenter Observational Study.

Ann Nutr Metab 2018 Dec 12;74(1):35-43. Epub 2018 Dec 12.

Emergency and Critical Care Medicine, Tokushima University Graduate School, Tokushima, Japan.

Background: There is lack of evidence regarding nutritional management among intensive care unit (ICU) patients in a population with relatively low body mass index. Therefore, we conducted an observational study to assess the nutritional management in Japanese ICUs. Also, we investigated the impact of nutritional management and rehabilitation on physical outcome. Read More

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December 2018

[Aspects of nutrition therapy of an infant with central nervous system tumour].

Magy Onkol 2018 Dec 22;62(4):237-241. Epub 2018 Nov 22.

II. Sz. Gyermekgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary.

The atypical teratoid/rhabdoid tumour (ATRT) is a rare type of central nervous system tumour appearing usually under 2 years of age. The survival of patients is insufficient despite the combined treatment (neurosurgical removal, intensive chemo- and radiotherapy). ATRT recurs one year after completion of treatment in 60% of cases. Read More

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December 2018

Cardiovascular disease risk in patients with hepatitis C infection: Results from two general population health surveys in Canada and the United States (2007-2017).

PLoS One 2018 12;13(12):e0208839. Epub 2018 Dec 12.

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

The role of hepatitis C virus (HCV) infection in increasing the risk of cardiovascular disease (CVD) is controversial. The objective of the present study is to estimate the 10-year risk of CVD in HCV- positive subjects and describe their profile of cardiometabolic risk markers compared to HCV-negative subjects. We conducted a cross-sectional study to estimate 10-year CVD risk, calculated using the Framingham Risk Score (FRS), in participants from the Canadian Health Measures Survey (CHMS; 2007-2015, n = 10,115) and the US-National Health and Nutrition Examination Survey (NHANES; 2007-2016, n = 16,668). Read More

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December 2018
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Lower circulating levels of CTRP12 and CTRP13 in polycystic ovarian syndrome: Irrespective of obesity.

PLoS One 2018 12;13(12):e0208059. Epub 2018 Dec 12.

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Altered production of adipokines is suggested to play a pivotal role in the pathogenesis of polycystic ovarian syndrome (PCOS). C1q/TNF-related proteins (CTRPs) play diverse roles in regulation of metabolism in physiologic and pathologic conditions. In the present study, we assessed serum concentrations of adiponectin, CTRP12, and CTRP13 in individuals with PCOS and those without PCOS. Read More

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December 2018

Low 25-hydroxyvitamin D levels are more prevalent in Canadians of South Asian than European ancestry inhabiting the National Capital Region of Canada.

PLoS One 2018 12;13(12):e0207429. Epub 2018 Dec 12.

Bureau of Nutritional Sciences, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada.

The US Institute of Medicine defined serum 25-hydroxyvitamin D (25OHD) cut point values of 30 nmol/L and 40 nmol/L were used to assess the vitamin D status of South Asian and European Canadians of self-identified ancestry living in the National Capital Region of Canada. Serum 25OHD values were measured in the spring and fall of 2012 to represent status during the winter and summer months, respectively. A total of 1238 measurements were obtained from 669 participants (49% South Asian ancestry): some participants were measured only once (spring or fall). Read More

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December 2018
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Association of Maternal Secretor Status and Human Milk Oligosaccharides With Milk Microbiota: An Observational Pilot Study.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Department of Biotechnology, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain.

Background And Objectives: Breast milk contains several bioactive factors including human milk oligosaccharides (HMOs) and microbes that shape the infant gut microbiota. HMO profile is determined by secretor status; however, their influence on milk microbiota is still uncovered. This study is aimed to determine the impact of the FUT2 genotype on the milk microbiota during the first month of lactation and the association with HMO. Read More

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December 2018
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Voluntary wheel running reveals sex specific nociceptive factors in murine experimental autoimmune encephalomyelitis.

Pain 2018 Dec 11. Epub 2018 Dec 11.

Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada, T6G 2E1.

Multiple Sclerosis (MS) is an inflammatory, neurodegenerative autoimmune disease associated with sensory and motor dysfunction. Although estimates vary, ∼50% of patients with MS experience pain during their disease. The mechanisms underlying the development of pain are not fully understood and no effective treatment for MS related pain is available. Read More

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December 2018

Autophagy and intermittent fasting: the connection for cancer therapy?

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e814s. Epub 2018 Dec 10.

Departamento de Farmacologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo (EPM-UNIFESP), Sao Paulo, SP, BR.

Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Read More

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December 2018

SOCIOECONOMIC AND NUTRITIONAL CHARACTERISTICS OF CHILDREN AND ADOLESCENTS WITH SICKLE CELL ANEMIA: A SYSTEMATIC REVIEW.

Rev Paul Pediatr 2018 Oct-Dec;36(4):491-499

Departamento de Pediatria, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Objective: To describe the socioeconomic and nutritional characteristics of children and adolescents with sickle cell anemia.

Data Sources: The present study is a systematic literature review based on published scientific articles. The searches were carried out using the electronic database of the National Library of Medicine, National Institutes of Health- PubMed. Read More

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THE USE OF ULTRASONOGRAPHY TO EVALUATE MUSCLE THICKNESS AND SUBCUTANEOUS FAT IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS.

Rev Paul Pediatr 2018 Oct-Dec;36(4):457-465

Programa de Pós-graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Objective: To compare muscle thickness and subcutaneous fat in cystic fibrosis (CF) patients and healthy controls using ultrasonography (US), and to correlate US findings with nutritional, clinical and functional variables.

Methods: Patients aged 6 to 18 years old with a diagnosis of CF and healthy controls were included. Participants underwent anthropometric measurements, an ultrasonographic evaluation of muscle thickness and subcutaneous fat in the triceps, quadriceps, and gastrocnemius regions, and skinfold thickness measurements. Read More

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TARGET, PRESCRIPTION AND INFUSION OF ENTERAL NUTRITIONAL THERAPY OF CRITICAL PATIENTS IN INTENSIVE CARE UNIT.

Arq Gastroenterol 2018 Jul-Sep;55(3):283-289

PUC, Programa de Pós-Graduação em Ciências da Saúde, Grupo de Pesquisa: Diagnóstico e Terapia Clínica e Cirúrgica, Campinas, SP, Brasil.

Background: Enteral nutritional therapy (ENT) is the best route for the nutrition of critically ill patients with improved impact on the clinical treatment of such patients.

Objective: To investigate the energy and protein supply of ENT in critically ill in-patients of an Intensive Care Unit (ICU).

Methods: Prospective longitudinal study conducted with 82 critically ill in-patients of an ICU, receiving ENT. Read More

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Evidence on nutritional assessment techniques and parameters used to determine the nutritional status of children and adolescents: systematic review.

Cien Saude Colet 2018 Dec;23(12):4209-4219

Programa de Pós-Graduação em Pediatria e Saúde da Criança, Pontifícia Universidade Católica do Rio Grande do Sul. Av. Ipiranga 6690/2º, Partenon. 90610-000 Porto Alegre RS Brasil.

This article aims to review systematically the evidence on nutritional assessment techniques and parameters used to determine the nutritional status of children and adolescents. The literature review and the selection of publications were performed using the Medline, Lilacs, SciELO, Embase, personal files. 17 studies were identified, 7 addressed the anthropometric indices as the main outcome, 7 analyzed the growth and development of children and adolescents through growth curves, and the remainder surveyed body composition. Read More

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December 2018

Consumption of dietary intake markers by patients with diabetes assessed using a mobile application.

Cien Saude Colet 2018 Dec;23(12):4199-4208

Programa de Pós-Graduação em Envelhecimento Humano, Universidade de Passo Fundo. BR 285, São José, 99052-900 Passo Fundo RS

The aim of this study was to assess the consumption of dietary intake markers in patients with diabetes using a mobile application. A cross-sectional study was conducted with 100 younger and older adult type 2 diabetes patients in treatment in a hospital in the State of Rio Grande do Sul, Brazil. Data was collected using the Diabetes Food Control app. Read More

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December 2018
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[Nutritional adequacy and food waste in Early Childhood Education Centers].

Cien Saude Colet 2018 Dec;23(12):4177-4188

Faculdade de Nutrição, Universidade Federal de Alagoas. BR 104 Norte Km 97, Tabuleiro do Martins. 57072-900 Maceió AL Brasil.

Analyzing quantitative and qualitative aspects of school meals represents the initial stage to ensure that the National School Food Program (PNAE) is an effective space for the promotion of healthy eating habits and establishing individual rights. The objective of this study was to evaluate the nutritional adequacy of meals served and consumed, as well as quantifying food waste in Child Daycare Centers in Maceió, in the state of Alagoas. All meals served and consumed by 359 children (aged 17 to 63 months) were analyzed by the direct weighing method for three non-consecutive days in all institutions. Read More

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December 2018

Health and Food and Nutritional Security Policies: challenges in controlling childhood obesity.

Cien Saude Colet 2018 Dec;23(12):4143-4152

Departamento de Nutrição Social, Faculdade de Nutrição, Universidade Federal Fluminense. R. Mario Santos Braga 30/4º, Centro. 24020-140 Niterói RJ Brasil.

The study analyzed the initiatives of prevention and control of childhood obesity, especially those of Adequate and Healthy Food Promotion (PAAS) which have been part of the policies of the Brazilian federal government for the last 15 years. All documents that feature PAAS initiatives in the food and nutrition security, as well as public health policy fields, were evaluated according to the following criteria: (1) the approach to PAAS initiatives; (2) the aspects of obesitythat they intend to affect and (3) potential interest disputes. The main PAAS initiatives identified are intended to encourage: food and nutrition education; agroecological production systems; family agriculture; food accessibility; healthy environments and regulatory measures. Read More

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December 2018
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[Challenges facing Food and Nutrition Security in the Amazon: availability and consumption in households with adolescents].

Cien Saude Colet 2018 Dec;23(12):4043-4054

Instituto de Saúde Coletiva, Faculdade de Ciências Exatas e da Terra, Universidade Federal de Mato Grosso (UFMT). Cuiabá MT Brasil.

Food and nutritional insecurity remains a challenge to the accomplishment of the right to adequate food in the Brazilian scenario. The scope of this study was to analyze the food and nutrition insecurity situation of adolescents both in households and on an individual level. A cross-sectional population-based study was conducted with 363 households and 95 adolescents in urban municipalities of the Brazilian Amazon. Read More

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December 2018

VITAMIN D DEFICIENCY AND PARATOHOMMONIUM INCREASE IN LATE POSTOPERATIVE GASTRIC BYPASS IN ROUX-EN-Y.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1407. Epub 2018 Dec 6.

Lane Clinic, Campinas, SP, Brazil.

Background : Roux-en-Y gastric bypass patients can experience changes in calcium metabolism and hyperparathyroidism secondary to vitamin D deficiency.

Aim : To evaluate nutritional deficiencies related to the calcium metabolism of patients undergoing gastric bypass with a 10-year follow-up.

Method : This is a longitudinal retrospective study of patients submitted to Roux-en-Y gastric bypass at a multidisciplinary clinic located in the Brazilian southeast region. Read More

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December 2018

Percutaneous transhepatic cholangial drainage combined with percutaneous endoscopic jejunostomy for maintaining nutrition state in patients with advanced ampullary neoplasms.

J Cancer Res Ther 2018 Dec;14(Supplement):S1158-S1162

Department of General Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, China.

Purpose: To investigate the role of percutaneous transhepatic cholangial drainage (PTCD) combined with percutaneous endoscopic jejunostomy (PEJ) in maintaining the nutrition state in patients with advanced ampullary neoplasms.

Materials And Methods: Sixty patients who suffered from advanced ampullary neoplasms and could not tolerate internal drainage operation or biliary stent placement were enrolled. After PTCD, PEJ was implemented, and then the enteral nutrient solution + bile were instilled through PEJ tube for enteral nutrition support. Read More

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December 2018

miR-27a is highly expressed in H1650 cancer stem cells and regulates proliferation, migration, and invasion.

J Cancer Res Ther 2018 Dec;14(Supplement):S1004-S1011

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Background: Cancer stem cells (CSCs) are responsible for tumor relapse after chemotherapy and radiotherapy in non-small cell lung cancer (NSCLC). The aim of this study is to explore the profile and role of microRNA (miRNA) in CSC of NSCLC.

Materials And Methods: We studied the expression of stem cell marker in side population cells and serum-free cultured spheres of NSCLC. Read More

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December 2018

Neuroinflammation as a target for glaucoma therapy.

Neural Regen Res 2019 Mar;14(3):391-394

Visual Neurophysiology and Neurophthalmology Research Unit, IRCCS G.B. Bietti Foundation, Roma, Italy.

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation - involving the activation and proliferation of resident glial cells (astrocytes, Muller cells and microglia) and the release of a plethora of anti- and pro-inflammatory cytokines, chemokines and reactive oxygen species - has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. Read More

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Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150 weeks of treatment.

Cytokine 2019 Jan 24;113:400-404. Epub 2018 Oct 24.

Department of Medicine, University Hospital Leipzig, 04103 Leipzig, Germany. Electronic address:

Aim: Metreleptin treatment in lipodystrophy patients improves eating behavior with increased satiety and reduced hunger. However, no data are available whether effects are maintained beyond 52 weeks of treatment.

Methods: A prospective study with measurements at baseline and at >150 weeks of metreleptin treatment was performed. Read More

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January 2019

Acutely malnourished weanling mice administered Flt3 ligand can support a cell-mediated inflammatory response.

Cytokine 2019 Jan 7;113:39-49. Epub 2018 Jul 7.

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada. Electronic address:

The main objective of this investigation was to determine whether, despite acute (wasting) deficits of dietary nitrogen and energy, weanling mice could respond to the dendritic cell hematopoietin, Fms-like tyrosine kinase 3 ligand (Flt3L), in terms of an index of cell-mediated inflammatory competence. Male and female C57BL/6J weanlings were used, initially 19 days of age, and malnutrition was produced using a nitrogen-deficient diet. In preliminary work ten daily subcutaneous 1. Read More

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January 2019

Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Viale Piazza D'Armi, 1, 28100, Novara, Italy.

Background: Physical exercise and nutrition seem to have a key role in the management of hip fracture patients.

Aim: To evaluate the impact of a 2-month rehabilitative protocol combined with dietetic counseling, with or without essential amino acid supplementation, on functioning in hip fracture patients.

Methods: In this pilot randomized controlled study, we recruited patients aged more than 65 years, at 3 months after hip fracture. Read More

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December 2018

Magnitude of Anemia and Associated Factors among Pregnant Women Attending Antenatal Care in Public Hospitals of Ilu Abba Bora Zone, South West Ethiopia: A Cross-Sectional Study.

Anemia 2018 12;2018:9201383. Epub 2018 Nov 12.

Department of Midwifery, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Anemia is a global public health problem affecting all population particularly pregnant women. Hence, this study assessed the magnitude of anemia and associated factors among pregnant.

Methods: Institution based cross-sectional study was conducted among 416 pregnant women attending antenatal clinic in three public hospitals of Ilu Aba Bora zone. Read More

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November 2018

Successful Localization Using Ga-DOTATOC PET/CT of a Phosphaturic Mesenchymal Tumor Causing Osteomalacia in a Patient with Concurrent Follicular Lymphoma.

Nucl Med Mol Imaging 2018 Dec 12;52(6):462-467. Epub 2018 Sep 12.

1Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505 South Korea.

Diagnosing tumor-induced osteomalacia is often challenging because conventional imaging modalities may fail to locate the responsible tumor. This report describes the ability of Ga-DOTATOC PET/CT to successfully distinguish between the responsible phosphaturic mesenchymal tumor and concurrent lymphoma lesions. A 52-year-old man with bone pain for several years was diagnosed with a vitamin D-resistant hypophosphatemic osteomalacia. Read More

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December 2018

The and Anticancer Properties of .

Evid Based Complement Alternat Med 2018 14;2018:1071243. Epub 2018 Nov 14.

Integrative Medicine Cluster, Institut Perubatan dan Pergigian Termaju (IPPT), Sains@BERTAM, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia.

, a fast-growing deciduous tree that is widely cultivated in tropical and subtropical regions of the world, is well known for its abundant uses. The tree is a source of food, shelter, and traditional medicine for many people, especially in developing countries. Many studies have been conducted to evaluate the various claims of traditional medicine practitioners that the moringa tree can improve health and treat various diseases. Read More

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November 2018

Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes.

Front Endocrinol (Lausanne) 2018 27;9:687. Epub 2018 Nov 27.

Nutrigenomics and Fish Growth Endocrinology, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Castellón, Spain.

The Gh/Prl/Sl family has evolved differentially through evolution, resulting in varying relationships between the somatotropic axis and growth rates within and across fish species. This is due to a wide range of endogenous and exogenous factors that make this association variable throughout season and life cycle, and the present minireview aims to better define the nutritional and environmental regulation of the endocrine growth cascade over precisely defined groups of fishes, focusing on Mediterranean farmed fishes. As a result, circulating Gh and Igf-i are revitalized as reliable growth markers, with a close association with growth rates of gilthead sea bream juveniles with deficiency signs in both macro- or micro-nutrients. Read More

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November 2018

Pelvic Exenteration Put into Therapeutical and Palliative Perspective: It Is Worth to Try.

Indian J Surg Oncol 2018 Dec 20;9(4):552-557. Epub 2018 Jul 20.

22nd Department of Surgery, Attikon Hospital, University of Athens Medical School, 1 Rimini Str, 124 10 Chaidari, Greece.

Pelvic exenteration (PE) is one of the most drastic operations in surgical oncology, associated with severe morbidity and mortality. The objective of our study was to review our experience of PE in terms of surgical characteristics, complications, and overall survival. All patients who had PE surgery between January 1999 and December 2015 were identified. Read More

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December 2018

Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China.

Background/objectives: The aim of the current study was to investigate the inhibitory effect of lycopene (LYC), a major carotenoid present in tomato, on high-fat and high-fructose western diet (HFFD)-induced cognitive impairments and the protective effects on HFFD-elicited insulin resistance, lipid metabolism dysfunction and inflammatory responses in the gut-liver-brain axis.

Subjects/methods: We randomly assigned 3-month-old C57BL/6 J mice to three groups with different diets: the control group, HFFD group and HFFD + LYC group (LYC, 0.03% w/w, mixed into high-fat diet) for 10 weeks. Read More

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December 2018

Prefronto-cerebellar neuromodulation affects appetite in obesity.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Bariatric and Nutritional Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Human neuroimaging studies have consistently reported changes in cerebellar function and integrity in association with obesity. To date, however, the nature of this link has not been studied directly. Emerging evidence suggests a role for the cerebellum in higher cognitive functions through reciprocal connections with the prefrontal cortex. Read More

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December 2018

Paternal grandfather's access to food predicts all-cause and cancer mortality in grandsons.

Nat Commun 2018 12 11;9(1):5124. Epub 2018 Dec 11.

Department of Economics, Priory Rd Complex, University of Bristol, Bristol, BS8 ITU, United Kingdom.

Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male line. A single historical dataset, the Överkalix cohorts in northern Sweden, is often quoted as evidence. Read More

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December 2018
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Impaired oral health status on admission is associated with poor clinical outcomes in post-acute inpatients: A prospective cohort study.

Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.

Department of Social Science, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka, Obu, Aichi, 474-8511, Japan.

Background & Aims: Oral health is an integral part of nutrition and rehabilitation. The purpose of this study was to investigate the impact of impaired oral health status on clinical and functional outcomes in post-acute in-hospital rehabilitation.

Methods: We conducted a prospective cohort study of hospitalized patients undergoing rehabilitation at a 225-bed post-acute rehabilitation hospital in Japan. Read More

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November 2018

Higher plane of nutrition pre-weaning enhances Holstein calf mammary gland development through alterations in the parenchyma and fat pad transcriptome.

BMC Genomics 2018 Dec 11;19(1):900. Epub 2018 Dec 11.

Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, 61801, USA.

Background: To reduce costs of rearing replacement heifers, researchers have focused on decreasing age at breeding and first calving. To increase returns upon initiation of lactation the focus has been on increasing mammary development prior to onset of first lactation. Enhanced plane of nutrition pre-weaning may benefit the entire replacement heifer operation by promoting mammary gland development and greater future production. Read More

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December 2018

Survival marker genes of colorectal cancer derived from consistent transcriptomic profiling.

BMC Genomics 2018 Dec 11;19(Suppl 8):857. Epub 2018 Dec 11.

Bioinformatics and Functional Genomics Group, Cancer Research Center (CiC-IBMCC, CSIC/USAL/IBSAL), Consejo Superior de Investigaciones Cientificas (CSIC) and University of Salamanca (USAL), Salamanca, Spain.

Background: Identification of biomarkers associated with the prognosis of different cancer subtypes is critical to achieve better therapeutic assistance. In colorectal cancer (CRC) the discovery of stable and consistent survival markers remains a challenge due to the high heterogeneity of this class of tumors. In this work, we identified a new set of gene markers for CRC associated to prognosis and risk using a large unified cohort of patients with transcriptomic profiles and survival information. Read More

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December 2018
1 Read

Feed your gut with caution!

Transl Cancer Res 2016 Sep;5(Suppl 3):S507-S513

Department of Nutritional Sciences, The Pennsylvania State University, University Park, State College, PA, USA.

The intestinal epithelium, a single layer of cells organized into crypts and villi, is an important component of host defense against microbial community and its noxious metabolites. To preserve the epithelium integrity under constant exposure of intense physiological and environmental stressors, this surface is continuously and rapidly renewed by pluripotent intestinal epithelial stem cells that reside in the base of crypts. A recent study by Kaiko . Read More

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September 2016

The association between diet and mood: A systematic review of current literature.

Psychiatry Res 2018 Dec 4;271:428-437. Epub 2018 Dec 4.

Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran; Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

A number of studies have examined the association between diet and mood state, but the findings have been inconclusive. Herein, we conducted a systematic review to assess the association between different diet and mood state. PubMed, Cochrane's library, Science direct, Scopus, Google scholar and ISI web of science databases were searched for all available literature until December 2017 for studies assessing the association between diet and mood state. Read More

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December 2018
2 Reads

Why we can't determine reliably the age of a subject on the basis of his maturation degree.

J Forensic Leg Med 2018 Dec 5;61:97-101. Epub 2018 Dec 5.

Past Director of the Complex Unit of Auxology, Faculty of Medicine and Surgery, Università degli Studi di Torino, Turin, Italy. Electronic address:

Background: Maturation is the irreversible biological process leading to adult form or function. The degree of maturation can be derived from the examination of maturity indicators, i.e. Read More

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December 2018
2 Reads

Parental and family predictors of fruits and vegetables in elementary school Children's home-packed lunches across a school week.

Appetite 2018 Dec 8. Epub 2018 Dec 8.

Department of Human Ecology, University of California, Davis 1309 Hart Hall, One Shields Avenue, Davis, CA, 95616, USA. Electronic address:

Home-packed lunches have been found to be of lower nutritional quality than school-bought lunches, yet little is known about family-based factors associated with lunch packing. The current exploratory study examines parental and family predictors of fruits and vegetables packed in lunches, hypothesizing parents' nutrition knowledge and authoritative parenting as well as children's involvement in lunch decisions would relate to packing more fruits and vegetables, while financial difficulties would relate to packing fewer. Ninety parent-child dyads from 4th-6th grade participated for 5 consecutive school days. Read More

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December 2018

Providing very preterm infants with donor human milk led to faster breastfeeding rates but worse biometric gains.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Neonatology, Puerta de Hierro Majadahonda University Hospital, Madrid.

Aim: To evaluate the immediate clinical impact of donor human milk availability in a NICU about nutritional, clinical and biometric parameters.

Methods: This retrospective-cohort study included 28-32 weeks gestational age born at our hospital in a three-year period before and after the donor human milk implementation. Data about starting, advance and discharge enteral nutrition, clinical outcomes, hospital stay and biometrics, was collected. Read More

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December 2018
1 Read

Serum cotinine, vitamin D exposure levels and dental caries experience in U.S. adolescents.

Community Dent Oral Epidemiol 2018 Dec 10. Epub 2018 Dec 10.

Oral Health Services Research Core, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Richmond, Virginia.

Introduction: Epidemiologic studies of risk and protective factors for poor oral health have mostly been among children and adults, seldom focusing on adolescents. The aims of this study were to examine whether serum cotinine, a marker of tobacco exposure, and serum vitamin D are independently associated with dental caries experience among adolescents.

Methods: Cross-sectional data from 2579 adolescent participants in the 2005-2008 National Health and Nutritional Examination Survey were analysed. Read More

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December 2018

Developing a highly efficient and wildly adaptive CRISPR-SaCas9 toolset for plant genome editing.

Plant Biotechnol J 2018 Dec 10. Epub 2018 Dec 10.

Key Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, 230031, China.

The CRISPR- Streptococcus pyogenes Cas9 (SpCas9) system offers a rapid, simple and flexible genome editing approach. However, the targeting scope of the SpCas9 system is limited by the canonical NGG PAM. To broaden the editing range of the CRISPR system, several Cas orthologs recognized different PAM were isolated from diverse microbes and were engineered as powerful genome editing tools in eukaryotic cells (Murovec et al. Read More

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December 2018
2 Reads

The LKB1-AMPK and mTORC1 Metabolic Signaling Networks in Schwann Cells Control Axon Integrity and Myelination: Assembling and upholding nerves by metabolic signaling in Schwann cells.

Authors:
Bogdan Beirowski

Bioessays 2018 Dec 11:e1800075. Epub 2018 Dec 11.

Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, 14203, USA.

The Liver kinase B1 with its downstream target AMP activated protein kinase (LKB1-AMPK), and the key nutrient sensor mammalian target of rapamycin complex 1 (mTORC1) form two signaling systems that coordinate metabolic and cellular activity with changes in the environment in order to preserve homeostasis. For example, nutritional fluctuations rapidly feed back on these signaling systems and thereby affect cell-specific functions. Recent studies have started to reveal important roles of these strategic metabolic regulators in Schwann cells for the trophic support and myelination of axons. Read More

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December 2018

Dressings and topical agents for preventing pressure ulcers.

Cochrane Database Syst Rev 2018 Dec 6;12:CD009362. Epub 2018 Dec 6.

School of Nursing & Midwifery, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, Ireland, D2.

Background: Pressure ulcers, localised injuries to the skin or underlying tissue, or both, occur when people cannot reposition themselves to relieve pressure on bony prominences. These wounds are difficult to heal, painful, expensive to manage and have a negative impact on quality of life. Prevention strategies include nutritional support and pressure redistribution. Read More

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December 2018
3 Reads

First Nations students' perceptions of school nutrition policy implementation: A mixed methods study.

Nutr Diet 2018 Nov;75(5):533-540

Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.

Aim: School nutrition policies can improve healthy food access for Indigenous First Nations children in Canada. This study explored First Nations students' perceptions of a school nutrition policy.

Methods: The research was a process evaluation of school nutrition policy implementation using a mixed-methods design. Read More

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November 2018

Bioaccessibility of carotenoids from plant and animal foods.

J Sci Food Agric 2018 Dec 7. Epub 2018 Dec 7.

Institute of Food Science and Biotechnology, Chair Plant Foodstuff Technology and Analysis, University of Hohenheim, Garbenstrasse 25, D-70599 Stuttgart, Germany.

The frequent consumption of carotenoid-rich foods has been associated with numerous health benefits such as the supply of provitamin A. In order to exert these health benefits, carotenoids need to be efficiently liberated from the food matrix, micellized in the small intestine, taken up by the enterocytes, and absorbed to the human blood stream. Enormous efforts have been made to better understand these processes. Read More

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December 2018

Oral health-related quality of life in patients with disorders of nutrition.

J Oral Rehabil 2018 Dec 11. Epub 2018 Dec 11.

Department of Community Dentistry, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.

Background: Researchers demonstrated a correlation between nutrition and health-related quality-of-life (HRQoL). Little is known about the correlation between disorders of nutrition (DON) and Oral HRQoL (OHRQoL).

Objectives: 1) to measure OHRQoL in DON patients compared to patients attending nutritional counseling for other reasons (e. Read More

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December 2018
1.934 Impact Factor