649 results match your criteria Nutritional Therapy and Metabolism [Journal]


Considerations to facilitate a US study that replicates PREDIMED.

Metabolism 2018 08 5;85:361-367. Epub 2018 May 5.

Department of Nutritional Sciences, Pennsylvania State University, College Park, PA, United States.

The PREDIMED clinical trial provided strong evidence that a Mediterranean dietary pattern (MedDiet) could help prevent cardiovascular disease (CVD) events in high risk middle-aged/older people. This report considers the feasibility of replicating PREDIMED in the U.S. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.05.001DOI Listing
August 2018
2 Reads

Gestational diabetes mellitus: Multi-disciplinary treatment approaches.

Metabolism 2018 Sep 6;86:91-101. Epub 2018 Apr 6.

Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Gestational diabetes mellitus (GDM) is the most common metabolic disease of pregnancy, associated with several perinatal complications. Adequate glycemic control has been proved to decrease risk of GDM-related complications. Several studies have shown the beneficial effect of exercise and medical nutrition treatment on glycemic and weight control in GDM-affected women. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.03.025DOI Listing
September 2018
7 Reads

Insight from mitochondrial functions and proteomics to understand cardiometabolic disorders in survivors of acute lymphoblastic leukemia.

Metabolism 2018 08 18;85:151-160. Epub 2018 Mar 18.

Research Centre, CHU-Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada; Department of Nutrition, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

Background: Childhood acute lymphoblastic leukemia (cALL) is the most prevalent form of cancer in children. Due to advances in treatment and therapy, young cALL subjects now achieve a 90% survival rate. However, this tremendous advance does not come without consequence since ~2/3 of cALL survivors are affected by long-term and late, severe complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183008
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http://dx.doi.org/10.1016/j.metabol.2018.03.011DOI Listing
August 2018
20 Reads

Effects of ovariectomy and exercise training intensity on energy substrate and hepatic lipid metabolism, and spontaneous physical activity in mice.

Metabolism 2018 06 6;83:234-244. Epub 2018 Mar 6.

Department of Kinesiology and Health, Rutgers University, New Brunswick, NJ, United States; Center for Lipid Research, Rutgers University, New Brunswick, NJ, United States.

Background: Menopause is associated with fatty liver, glucose dysregulation, increased body fat, and impaired bone quality. Previously, it was demonstrated that single sessions of high-intensity interval exercise (HIIE) are more effective than distance- and duration-matched continuous exercise (CE) on altering hepatic triglyceride (TG) metabolism and very-low density lipoprotein-TG (VLDL-TG) secretion.

Methods: Six weeks training using these modalities was examined for effects on hepatic TG metabolism/secretion, glucose tolerance, body composition, and bone mineral density (BMD) in ovariectomized (OVX) and sham-operated (SHAM) mice. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.02.011DOI Listing
June 2018
10 Reads

Caloric restriction improves glucose homeostasis, yet increases cardiometabolic risk in caveolin-1-deficient mice.

Metabolism 2018 06 2;83:92-101. Epub 2018 Feb 2.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

Background And Purpose: The plasma membrane protein caveolin-1 (CAV-1) has been shown to be involved in modulating glucose homeostasis and the actions of the renin-angiotensin-aldosterone system (RAAS). Caloric restriction (CR) is widely accepted as an effective therapeutic approach to improve insulin sensitivity and reduce the severity of diabetes. Recent data indicate that polymorphisms of the CAV-1 gene are strongly associated with insulin resistance, hypertension and metabolic abnormalities in non-obese individuals. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.01.012DOI Listing
June 2018
3 Reads

Balanced high fat diet reduces cardiovascular risk in obese women although changes in adipose tissue, lipoproteins, and insulin resistance differ by race.

Metabolism 2018 05 31;82:125-134. Epub 2018 Jan 31.

Vanderbilt University Medical Center, School of Medicine, Department of Medicine, United States; Veterans Affairs Tennessee Valley Healthcare System, United States. Electronic address:

Background: We previously reported that consuming a balanced high fat diet (BHFD) wherein total saturated fat was reduced and total unsaturated fat increased by proportionately balancing the type of fat (1/3 saturated, 1/3 monounsaturated, 1/3 polyunsaturated) led to significant improvements in inflammatory burden, blood pressure, and vascular function in obese premenopausal European American (EA) and African American (AA) women.

Objective: Here we compared changes in adipose tissue, lipoproteins, insulin resistance, and cardiovascular risk between EA and AA women.

Methods: Dietary intakes, plasma fatty acids, lipids, apolipoproteins, lipoproteins, HOMA-IR and ASCVD risk was measured in 144 women who consumed BHFD for 16 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183002
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http://dx.doi.org/10.1016/j.metabol.2018.01.020DOI Listing
May 2018
4 Reads

Effects of a combined dietary, exercise and behavioral intervention and sympathetic system on body weight maintenance after intended weight loss: Results of a randomized controlled trial.

Metabolism 2018 06 31;83:60-67. Epub 2018 Jan 31.

Department of Endocrinology & Metabolism, Charite - Universitätsmedizin Berlin, Germany; Charité-Center for Cardiovascular Research (CCR), Berlin, Germany; Clinical Research Unit, Berlin Institute of Health (BIH); DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany.

Background: Lifestyle based weight loss interventions are hampered by long-term inefficacy. Prediction of individuals successfully reducing body weight would be highly desirable. Although sympathetic activity is known to contribute to energy homeostasis, its predictive role in body weight maintenance has not yet been addressed. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.01.003DOI Listing
June 2018
8 Reads

A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial.

Metabolism 2018 05 3;82:111-117. Epub 2018 Jan 3.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States; Metabolic Research Center, Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH, United States. Electronic address:

Background: Whole-grain intake is associated with lower risk of type 2 diabetes but the mechanisms are unclear.

Purpose: We tested the hypothesis that a WG diet reduces insulin resistance and improves glucose use in individuals at risk for type 2 diabetes compared with an isocaloric-matched refined-grain diet.

Methods: A double-blind, randomized, controlled, crossover trial of 14 moderately obese adults (Age, 38 ± 2 y; BMI, 34. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930046PMC
May 2018
10 Reads

Nutrient excess and autophagic deficiency: explaining metabolic diseases in obesity.

Metabolism 2018 05 28;82:14-21. Epub 2017 Dec 28.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

Over-nutrition and a sedentary lifestyle are the driving forces behind the development of metabolic diseases. Conversely, caloric restriction and exercise have proven to be the most effective strategies in combating metabolic diseases. Interestingly, exercise and caloric restriction share a common feature: both represent a potent mechanism for upregulating autophagy. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.12.007DOI Listing
May 2018
4 Reads

Protein sparing therapies in acute illness and obesity: a review of George Blackburn's contributions to nutrition science.

Metabolism 2018 02 7;79:83-96. Epub 2017 Dec 7.

Section of Endocrinology, Diabetes, Nutrition and Weight Management, Boston University School of Medicine, 720 Harrison Ave, 8th floor, Suite 801, Boston, MA 02118, United States. Electronic address:

Protein sparing therapies were developed to mitigate the harms associated with protein-calorie malnutrition and nitrogen losses induced by either acute illness or hypocaloric diets in patients with obesity. We review the development of protein sparing therapies in illness and obesity with a focus on the pioneering contributions of George Blackburn, MD, PhD. He recognized that protein-calorie malnutrition is a common and serious clinical condition and developed new approaches to its treatment in hospitalized patients. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809291PMC
February 2018
5 Reads

NFIL3 is a negative regulator of hepatic gluconeogenesis.

Metabolism 2017 12 31;77:13-22. Epub 2017 Aug 31.

Division of Life Sciences, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul 02841, Republic of Korea. Electronic address:

Objective: Nuclear factor interleukin-3 regulated (NFIL3) has been known as an important transcriptional regulator of the development and the differentiation of immune cells. Although expression of NFIL3 is regulated by nutritional cues in the liver, the role of NFIL3 in the glucose metabolism has not been extensively studied. Thus, we wanted to explore the potential role of NFIL3 in the control of hepatic glucose metabolism. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.08.007DOI Listing
December 2017
6 Reads

Keto-adaptation enhances exercise performance and body composition responses to training in endurance athletes.

Metabolism 2018 04 3;81:25-34. Epub 2017 Nov 3.

Department of Sport, and Exercise Science, Waterford Institute of Technology, Waterford, Ireland. Electronic address:

Background: Low-carbohydrate diets have recently grown in popularity among endurance athletes, yet little is known about the long-term (>4wk) performance implications of consuming a low-carbohydrate high fat ketogenic diet (LCKD) in well-trained athletes.

Methods: Twenty male endurance-trained athletes (age 33±11y, body mass 80±11kg; BMI 24.7±3. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.10.010DOI Listing
April 2018
8 Reads

Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway.

Metabolism 2018 02 24;79:10-23. Epub 2017 Nov 24.

Guangdong Province Key Laboratory of Animal Nutritional Regulation, 483 Wushan Road, Tianhe District, Guangzhou, Guangdong 510642, China; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, Guangdong 510642, China. Electronic address:

Objective: Growth hormone stimulates growth by increasing insulin-like growth factor 1 expression and secretion. In the presence of insufficient nutrients, GH increases, whereas IGF-1 expression becomes severely suppressed, leading to GH resistance. This study aimed to explore the effect of arginine (Arg) on GH resistance during malnutrition and to describe its underlying mechanism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495173028
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http://dx.doi.org/10.1016/j.metabol.2017.10.006DOI Listing
February 2018
15 Reads
3.890 Impact Factor

Adverse glycaemic effects of cancer therapy: indications for a rational approach to cancer patients with diabetes.

Metabolism 2018 01 7;78:141-154. Epub 2017 Oct 7.

Department of Clinical Medicine and Surgery, University "Federico II", Naples, Italy.

Diabetes and cancer are common, chronic, and potentially fatal diseases that frequently co-exist. Observational studies have reported an increased risk of cancer in patients with diabetes. Furthermore, many patients with cancer already have diabetes, or develop hyperglycaemia as a consequence of the tumor or of cancer therapies, and coexisting diabetes confers a greater risk of mortality for many malignancies. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.09.013DOI Listing
January 2018
7 Reads

Associations of cord blood metabolites with perinatal characteristics, newborn anthropometry, and cord blood hormones in project viva.

Metabolism 2017 11 17;76:11-22. Epub 2017 Jul 17.

Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Context: Metabolomics has emerged as a powerful tool to characterize biomarkers and elucidate physiological processes underlying adverse health outcomes. Little is known of these relationships during gestation and infancy, which are critical period for development of metabolic disease risk.

Objectives: To identify cord blood metabolite patterns associated with birth size; and to investigate relations of the birth size-associated metabolite patterns, and a branched chain amino acid (BCAA) metabolite pattern with a range of newborn and perinatal characteristics. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675164PMC
November 2017
18 Reads

The association between immunoglobulin concentrations and prediabetes prevalence in a large Chinese cohort.

Metabolism 2017 08 31;73:77-84. Epub 2017 May 31.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China; Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:

Aims: Prediabetes has received public attention owing to the increasing prevalence worldwide. Mounting evidence has indicated that inflammation directly contributed to the etiology of glucose metabolism disorders. Although immunoglobulins play a crucial role in immune responses, little research has been done on the link between immunoglobulins and prediabetes in adults. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.05.008DOI Listing
August 2017
10 Reads

High insulin-like growth factor-binding protein-1 (IGFBP-1) is associated with low relative muscle mass in older women.

Metabolism 2017 08 1;73:36-42. Epub 2017 May 1.

Unit of Nutritional Epidemiology, The National Institute for Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden. Electronic address:

Objective: Skeletal muscles serve several important roles in maintaining good health. Insulin-like growth factor-1 (IGF-1) is a promoter of protein synthesis in skeletal muscle. Its binding protein, Insulin-like growth factor-binding protein-1 (IGFBP-1) can be one determinant of IGF-1 activity. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.04.013DOI Listing
August 2017
6 Reads

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition.

Metabolism 2017 06 9;71:70-82. Epub 2017 Mar 9.

Division of Nutritional Sciences, University of Illinois, Urbana, IL, USA; Department of Animal Sciences, University of Illinois, Urbana, IL, USA; Department of Pathology, Program in Integrative Immunology and Behavior, University of Illinois, Urbana, IL, USA. Electronic address:

Background: Inflammation within the central nervous system (CNS) is frequently comorbid with anxiety. Importantly, the pro-inflammatory cytokine most commonly associated with anxiety is IL-1β. The bioavailability and activity of IL-1β are regulated by caspase-1-dependent proteolysis vis-a-vis the inflammasome. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439304PMC
June 2017
9 Reads

Effect of a single bout of aerobic exercise on high-fat meal-induced inflammation.

Metabolism 2017 06 8;71:144-152. Epub 2017 Mar 8.

Department of Kinesiology, Iowa State University, Ames, IA. Electronic address:

Background And Aims: Chronic low-grade inflammation is involved in the development of metabolic disorders including atherosclerosis, type 2 diabetes (T2D) and metabolic syndrome. Aerobic exercise has been shown to be anti-inflammatory and attenuate postprandial blood lipids, however, the effect of exercise on postprandial inflammation remains unclear. The aim of this study was to determine the protective effect of a single bout of aerobic exercise against postprandial lipemia and peripheral blood mononuclear cell (PBMC) inflammation and to evaluate associations with changes in the energy-sensing enzyme, AMP-activated protein kinase (AMPK). Read More

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http://dx.doi.org/10.1016/j.metabol.2017.03.001DOI Listing
June 2017
66 Reads

Insulin-induced inhibition of gluconeogenesis genes, including glutamic pyruvic transaminase 2, is associated with reduced histone acetylation in a human liver cell line.

Metabolism 2017 06 23;71:118-124. Epub 2017 Mar 23.

Laboratory of Nutritional Physiology, Department of Nutrition and Life Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan. Electronic address:

Objectives: Hepatic glutamic pyruvic transaminase (GPT; also known as alanine aminotransferase) is a gluconeogenesis enzyme that catalyzes conversions between alanine and pyruvic acid. It is also used as a blood biomarker for hepatic damage. In this study, we investigated whether insulin regulates GPT expression, as it does for other gluconeogenesis genes, and if this involves the epigenetic modification of histone acetylation. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.03.009DOI Listing
June 2017
20 Reads

Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy.

Metabolism 2017 05 12;70:85-97. Epub 2017 Feb 12.

Rio de Janeiro Federal University, Josué de Castro Nutrition Institute, Department of Social and Applied Nutrition, Avenida Carlos Chagas Filho, 373 - CCS - Bloco J, Suite 29, Cidade Universitária - Ilha do Fundão, Rio de Janeiro, RJ, 21941-590, Brazil. Electronic address:

Objective: To evaluate the associations between first trimester 25-hydroxyvitamin D [25(OH)D] status and changes in high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), triglyceride (TG) concentrations, TG/HDL-c, and TC/HDL-c ratios throughout pregnancy. We hypothesized that first trimester 25(OH)D inadequacy is associated with lower concentrations of HDL-c and higher LDL-c, TC, TG, TG/HDL-c, and TC/HDL-c ratios throughout pregnancy.

Methods: A prospective cohort study with 3 visits at 5-13 (baseline), 20-26, and 30-36 gestational weeks, recruited 194 pregnant women attending a public health care center in Rio de Janeiro, Brazil. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.02.004DOI Listing
May 2017
23 Reads

Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D administration.

Metabolism 2017 May 11;70:31-41. Epub 2017 Feb 11.

Division of Endocrinology, Metabolism & Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Center for Cystic Fibrosis and Airways Disease Research, Children's Healthcare of Atlanta, Atlanta, GA, USA; Section of Endocrinology, Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA.

Background: Cystic fibrosis (CF) is a chronic catabolic disease often requiring hospitalization for acute episodes of worsening pulmonary exacerbations. Limited data suggest that vitamin D may have beneficial clinical effects, but the impact of vitamin D on systemic metabolism in this setting is unknown.

Objective: We used high-resolution metabolomics (HRM) to assess the impact of baseline vitamin D status and high-dose vitamin D administration on systemic metabolism in adults with CF with an acute pulmonary exacerbation. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407388PMC
May 2017
29 Reads

The use of magnetic resonance imaging to characterize abnormal body composition phenotypes in youth with Prader-Willi syndrome.

Metabolism 2017 04 16;69:67-75. Epub 2017 Jan 16.

Department of Pediatrics, University of Alberta, 11405-87 Avenue, Edmonton, AB, Canada T6G 2R3. Electronic address:

Introduction: Magnetic resonance imaging (MRI) provides detailed assessment of body composition compartments. No studies have employed state-of-the-art MRI methods to accurately examine abdominal adipose tissue (AT) and skeletal muscle in youth with Prader-Willi syndrome (PWS). Therefore, this study aimed to describe AT distribution and skeletal muscle in the abdominal region of youth with PWS using MRI. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.01.020DOI Listing
April 2017
2 Reads

Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice.

Metabolism 2017 04 4;69:177-187. Epub 2017 Jan 4.

Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: For successful treatment for nonalcoholic steatohepatitis (NASH), it may be important to treat the individual causative factors. At present, however, there is no established treatment for this disease. Branched-chain amino acids (BCAAs) have been used to treat patients with decompensated cirrhosis. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.12.013DOI Listing
April 2017
24 Reads

Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial.

Metabolism 2017 Apr 19;69:148-156. Epub 2017 Jan 19.

Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy; Centre for Immunobiology, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK. Electronic address:

Background And Aims: Nutritional therapy is recommended for management of reactive hypoglycemia (RH), a condition characterized by hypoglycemia that occurs within four hours after a meal. The macrobiotic Ma-Pi 2 diet improves glycemic control in subjects with type 2 diabetes. We explored the effect of this diet on outcomes in non-diabetic individuals with RH. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.01.023DOI Listing
April 2017
15 Reads

Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults.

Metabolism 2017 Apr 20;69:120-129. Epub 2016 Dec 20.

Center for Translational Research in Aging & Longevity, Dept. of Health and Kinesiology, Texas A&M University, College Station, TX, U.S.A.; Dept. of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A.

Background: The development of effective nutritional strategies in support of muscle growth for patients with chronic obstructive pulmonary disease (COPD) remains challenging. Dietary essential amino acids (EAAs) are the main driver of postprandial net protein anabolism. In agreement, EAA supplements in healthy older adults are more effective than supplements with the composition of complete proteins. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351771PMC
April 2017
13 Reads

Frailty and nutrition: From epidemiological and clinical evidence to potential mechanisms.

Metabolism 2017 03 11;68:64-76. Epub 2016 Dec 11.

Department of Social Medicine, Psychiatry and Neurology, National and Kapodistrian, University of Athens, Greece; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, NY, New York, USA.

Frailty is a geriatric condition characterized by unintentional weight loss, low muscle strength, feeling of exhaustion, reduced physical activity capacity and slow walking speed. Theoretically, nutrition is a factor closely related to the frailty syndrome: all frailty criteria are more or less affected by poor eating habits, whereas frailty itself may have a negative effect on eating and, thus, on the nutritional status. Indeed, research data suggest an association between frailty and specific constituents of diet, namely protein and energy intake, as well as intakes of specific micronutrients. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.12.005DOI Listing
March 2017
23 Reads

Effects of lifestyle interventions on clinical characteristics of patients with non-alcoholic fatty liver disease: A meta-analysis.

Metabolism 2017 Mar 16;68:119-132. Epub 2016 Dec 16.

Department of Nutrition & Dietetics, School of Health Sciences and Education, Harokopio University, 70 El. Venizelou Str., 176 71, Athens, Greece. Electronic address:

Background/objectives: Although lifestyle modifications remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD), the optimal lifestyle intervention is still controversial. The aim of this meta-analysis was to evaluate the effect of exercise and/or dietary interventions, type or intensity of exercise and type of diet, on liver function outcomes (liver enzymes, intrahepatic fat and liver histology), as well as on anthropometric and glucose metabolism parameters in NAFLD patients.

Subjects/methods: Literature search was performed in Scopus and US National Library of Medicine databases to identify all randomized controlled clinical trials (RCTs) in adult patients with NAFLD, diagnosed through imaging techniques or liver biopsy, published in English between January 2005 and August 2016. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.12.006DOI Listing
March 2017
48 Reads
3.894 Impact Factor

Association between sleep duration and osteoporosis risk in middle-aged and elderly women: A systematic review and meta-analysis of observational studies.

Metabolism 2017 Apr 26;69:199-206. Epub 2017 Jan 26.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Increasing evidence has suggested an association between sleep duration and osteoporosis risk, although the results of previous studies have been inconsistent. To our knowledge, this is the first meta-analysis of the literature and quantitative estimates of the association between sleep duration and risk of osteoporosis in population-based studies of middle aged and elderly women.

Methods: Pertinent studies were identified by searching PubMed and EMBASE databases up to February 2016. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.01.027DOI Listing
April 2017
10 Reads
2 Citations
3.894 Impact Factor

Mechanical circulatory support for end-stage heart failure.

Authors:
Alain Combes

Metabolism 2017 Apr 11;69S:S30-S35. Epub 2017 Jan 11.

Medical-Surgical Intensive Care Unit, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, F-75013 Paris, France; Sorbonne University, UPMC Univ Paris 06, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, F-75013 Paris, France. Electronic address:

Mechanical circulatory assistance has become a frequent therapeutic option for patients with advanced heart failure. For patients with acute cardiogenic shock and impaired organ function, short-term assistance with venoarterial extracorporeal membrane oxygenation is the leading therapeutic option. It enables a "bridge to decision-making" i. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.01.009DOI Listing
April 2017
8 Reads

Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.

Metabolism 2017 Feb 1;67:31-40. Epub 2016 Oct 1.

Department of Exercise Science, Concordia University, 7141 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Nutrition, Obesity and Metabolism Laboratory, PERFORM Centre, Concordia University, 7200 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5. Electronic address:

Aims: Enlarged adipocytes are a prime feature of adipose tissue dysfunction, and may be an appropriate target to decrease disease risk in obesity. We aimed to assess the change in adipocyte size in response to lifestyle and surgical weight loss interventions for overweight or obesity; and to explore whether certain participant and intervention characteristics influence this response.

Methods: We systematically searched MEDLINE, EMBASE, CINAHL and Cochrane electronic databases to identify weight loss studies that quantified adipocyte size before and after the intervention. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.09.009DOI Listing
February 2017
8 Reads

Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels.

Metabolism 2017 Jan 22;66:14-22. Epub 2016 Sep 22.

Department of Medicine, University of Missouri, Columbia, MO, USA; Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, USA; Division of Endocrinology and Metabolism, Diabetes Cardiovascular Center, University of Missouri, Columbia, MO, USA; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA. Electronic address:

Objective: Obesity is a global epidemic with profound cardiovascular disease (CVD) complications. Obese women are particularly vulnerable to CVD, suffering higher rates of CVD compared to non-obese females. Diastolic dysfunction is the earliest manifestation of CVD in obese women but remains poorly understood with no evidence-based therapies. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.09.005DOI Listing
January 2017
14 Reads

Weight loss induced by very low calorie diet is associated with a more beneficial systemic inflammatory profile than by Roux-en-Y gastric bypass.

Metabolism 2016 Nov 16;65(11):1614-1620. Epub 2016 Aug 16.

Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Introduction: Weight loss interventions such as Roux-en-Y gastric bypass (RYGB) and very low calorie diets (VLCD) lead to improvement of glucose metabolism in obese individuals with type-2 diabetes. Weight loss can also positively influence the unfavorable inflammatory profile associated with obesity. However, a direct comparison of the effect of VLCD and RYGB on systemic inflammation is lacking. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.07.013DOI Listing
November 2016
18 Reads

Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status.

Metabolism 2016 Nov 25;65(11):1605-1613. Epub 2016 Jul 25.

Department of Family Medicine and Public Health, School of Medicine, University of California, San Diego, La Jolla, CA, USA.

Background: Obesity is a risk factor for postmenopausal breast cancer incidence and premenopausal and postmenopausal breast cancer mortality, which may be explained by several metabolic and hormonal factors (sex hormones, insulin resistance, and inflammation) that are biologically related. Differential effects of dietary composition on weight loss and these metabolic factors may occur in insulin-sensitive vs. insulin-resistant obese women. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802865PMC
November 2016
11 Reads

BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver.

Metabolism 2016 10 9;65(10):1478-88. Epub 2016 Jul 9.

Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, Laboratory of Nutritional Physiology, University of Shizuoka, Shizuoka, Japan. Electronic address:

Objective: Fructose intake induces hepatic steatosis by activating fat synthesis. In this study, we searched for genes that showed acute induction in the livers of mice force-fed with fructose, and examined how this induction is regulated.

Materials/methods: We identified genes induced at 6h after the fructose force-feeding using a microarray and quantitative real-time RT-PCR. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.07.001DOI Listing
October 2016
12 Reads

ANP system activity predicts variability of fat mass reduction and insulin sensitivity during weight loss.

Metabolism 2016 Jun 7;65(6):935-43. Epub 2016 Apr 7.

Department of Endocrinology & Metabolism, Charite - Universitätsmedizin, Berlin, Germany; Charité-Center for Cardiovascular Research (CCR), Berlin, Germany; Experimental and Clinical Research Center (ECRC), Berlin, Germany. Electronic address:

Introduction: In weight loss trials, a considerable inter-individual variability in reduction of fat mass and changes of insulin resistance is observed, even under standardized study conditions. The underlying mechanisms are not well understood. Given the metabolic properties of the atrial natriuretic peptide (ANP) system, we hypothesized that ANP signaling might be involved in this phenomenon by changes of ANP secretion or receptor balance. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.03.013DOI Listing
June 2016
17 Reads

Hepatic autophagy contributes to the metabolic response to dietary protein restriction.

Metabolism 2016 06 3;65(6):805-15. Epub 2016 Mar 3.

Neurosignaling, Imaging and Culture Core, Pennington Biomedical Research Center, Baton Rouge, LA 70808. Electronic address:

Autophagy is an essential cellular response which acts to release stored cellular substrates during nutrient restriction, and particularly plays a key role in the cellular response to amino acid restriction. However, there has been limited work testing whether the induction of autophagy is required for adaptive metabolic responses to dietary protein restriction in the whole animal. Here, we found that moderate dietary protein restriction led to a series of metabolic changes in rats, including increases in food intake and energy expenditure, the downregulation of hepatic fatty acid synthesis gene expression and reduced markers of hepatic mitochondrial number. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867053PMC
June 2016
12 Reads

Metabolic profile in women with polycystic ovary syndrome across adult life.

Metabolism 2016 May 16;65(5):776-82. Epub 2016 Jan 16.

Endocrinology and Metabolism Laboratory, West Division, School of Medicine, Hospital San Juan de Dios, University of Chile, Santiago, Chile. Electronic address:

Objective: To assess insulin sensitivity, insulin secretion and metabolic profile in women with polycystic ovary syndrome (PCOS) in different stages of reproductive life.

Materials And Methods: In a cross-sectional study, 190 PCOS women (PCOSw) and 99 controls (Cw) aged between 18 and 55years were included. PCOSw and Cw were distributed into 3 stages of reproductive life: early reproductive age (18-34years old), late reproductive age (35-40years old) and perimenopausal period (41-55years old). Read More

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http://dx.doi.org/10.1016/j.metabol.2016.01.006DOI Listing
May 2016
7 Reads

Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the Diabetes Prevention Program.

Metabolism 2016 May 2;65(5):764-75. Epub 2015 Dec 2.

Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO, 63110.

Objective: In addition to slowing diabetes development among participants in the Diabetes Prevention Program (DPP), intensive lifestyle change and metformin raised HDL-cholesterol (HDL-C) compared to placebo treatment. We investigated the lifestyle and metabolic determinants as well as effects of biomarkers of inflammation, endothelial dysfunction and coagulation and their changes resulting from lifestyle and metformin interventions on the increase in HDL-C in the DPP.

Methods: The effects of a 1year period of intensive lifestyle change aimed at achieving 7% weight loss or metformin 850mg twice daily versus placebo on HDL-C were assessed in 3070 participants with impaired glucose tolerance, and on HDL particle concentration (HDL-P) and size in a subgroup of 1645 individuals. Read More

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http://dx.doi.org/10.1016/j.metabol.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122461PMC
May 2016
15 Reads

Aerobic and resistance training dependent skeletal muscle plasticity in the colon-26 murine model of cancer cachexia.

Metabolism 2016 May 4;65(5):685-98. Epub 2016 Feb 4.

Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, USA; The Center for Advancing Exercise and Nutrition Research on Aging, Florida State University, Tallahassee, FL, USA. Electronic address:

Purpose: The appropriate mode of exercise training for cancer cachexia is not well-established. Using the colon-26 (C26) mouse model of cancer cachexia, we defined and compared the skeletal muscle responses to aerobic and resistance training.

Methods: Twelve-month old Balb/c mice were initially assigned to control, aerobic training (AT; wheel running), or resistance training (RT; ladder climbing) (n=16-17/group). Read More

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http://dx.doi.org/10.1016/j.metabol.2016.01.014DOI Listing
May 2016
25 Reads

Targeting specific interstitial glycemic parameters with high-intensity interval exercise and fasted-state exercise in type 2 diabetes.

Metabolism 2016 May 11;65(5):599-608. Epub 2016 Jan 11.

Faculty of Physical Education & Recreation, University of Alberta, 1-052 Li Ka Shing Center for Health Research Innovation, Physical Activity and Diabetes Laboratory, Edmonton, Alberta, Canada, T6G 2H9. Electronic address:

Aims: To compare the acute glycemic responses to a bout of high-intensity interval exercise (HIIE) and energy-matched moderate-intensity continuous exercise (MICE) performed under fasted and postprandial conditions.

Methods: A randomized, controlled, crossover design was used. Ten individuals with type 2 diabetes were each tested in five experimental conditions after an overnight fast: 1) fasted-state HIIE (HIIEfast); 2) post-breakfast HIIE (HIIEfed); 3) fasted-state MICE (MICEfast); 4) post-breakfast MICE (MICEfed); and 5) no exercise (control). Read More

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http://dx.doi.org/10.1016/j.metabol.2016.01.003DOI Listing
May 2016
14 Reads

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease.

Metabolism 2016 Aug 3;65(8):1049-61. Epub 2016 Mar 3.

Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. Electronic address:

The exposure of hepatocytes to high concentrations of lipids and carbohydrates and the ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A common denominator is metabolic derangement, especially in regards to intracellular energy homeostasis, which is brought on by glucose intolerance and insulin resistance in tissues. In this review, we highlight the lipids and carbohydrates that provoke hepatocyte injury and the mechanisms involved in lipotoxicity and glucotoxicity, including endoplasmic reticulum stress, oxidative stress and mitochondrial impairment. Read More

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http://dx.doi.org/10.1016/j.metabol.2016.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931958PMC
August 2016
8 Reads

Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver.

Metabolism 2016 Apr 18;65(4):482-91. Epub 2015 Dec 18.

Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan. Electronic address:

Objective: Peripheral clock genes show a circadian rhythm is correlated with the timing of feeding in peripheral tissues. It was reported that these clock genes are strongly regulated by insulin action and that a high-fat diet (HFD) intake in C57BL/6J mice for 21days induced insulin secretion during the dark phase and reduced the circadian rhythm of clock genes. In this study, we examined the circadian expression patterns of these clock genes in insulin-resistant animal models with excess secretion of insulin during the day. Read More

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http://dx.doi.org/10.1016/j.metabol.2015.12.003DOI Listing
April 2016
10 Reads

Nutrients, foods, dietary patterns and telomere length: Update of epidemiological studies and randomized trials.

Metabolism 2016 Apr 17;65(4):406-15. Epub 2015 Nov 17.

Lipid Clinic, Endocrinology and Nutrition Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Spain.

Identifying simple strategies to prevent or delay age-associated pathologies is a major public health concern. Attrition of telomeres, chromatin structures that help maintain genome stability, leads to cell death or senescence. Thus telomere length is a reliable hallmark of biological aging and the risk of developing age-related chronic diseases through common oxidation and inflammation mechanisms. Read More

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http://dx.doi.org/10.1016/j.metabol.2015.11.004DOI Listing
April 2016
18 Reads

Metabolic characteristics of keto-adapted ultra-endurance runners.

Metabolism 2016 Mar 2;65(3):100-10. Epub 2015 Nov 2.

School of Medicine (emeritus), University of California, Davis, Davis, CA, USA.

Background: Many successful ultra-endurance athletes have switched from a high-carbohydrate to a low-carbohydrate diet, but they have not previously been studied to determine the extent of metabolic adaptations.

Methods: Twenty elite ultra-marathoners and ironman distance triathletes performed a maximal graded exercise test and a 180 min submaximal run at 64% VO2max on a treadmill to determine metabolic responses. One group habitually consumed a traditional high-carbohydrate (HC: n=10, %carbohydrate:protein:fat=59:14:25) diet, and the other a low-carbohydrate (LC; n=10, 10:19:70) diet for an average of 20 months (range 9 to 36 months). Read More

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http://dx.doi.org/10.1016/j.metabol.2015.10.028DOI Listing
March 2016
33 Reads

Hypovitaminosis D in bariatric surgery: A systematic review of observational studies.

Metabolism 2016 Apr 19;65(4):574-85. Epub 2015 Dec 19.

Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Obesity is a public health problem that carries global and substantial social and economic burden. Relative to non-surgical interventions, bariatric surgery has the most substantial and lasting impact on weight loss. However, it leads to a number of nutritional deficiencies requiring long term supplementation. Read More

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http://dx.doi.org/10.1016/j.metabol.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792683PMC
April 2016
9 Reads

Exercise and diet in the management of nonalcoholic fatty liver disease.

Metabolism 2016 Aug 6;65(8):1172-82. Epub 2015 Nov 6.

Storr Liver Centre, Westmead Millennium Institute for Medical Research and Westmead Hospital, the University of Sydney, NSW, Australia.

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition worldwide, and is projected to become the leading cause for liver transplantation in the United States as early as 2020. The mainstay of treatment remains lifestyle modification with diet and exercise recommendations, as although some pharmacological treatments such as glitazones and Vitamin E have shown benefit, there are concerns regarding long term safety. The evidence base for dietary interventions in NAFLD such as the Mediterranean diet, omega-3 polyunsaturated fatty acids and coffee is mainly derived from observational data with questionable validity. Read More

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http://dx.doi.org/10.1016/j.metabol.2015.10.032DOI Listing
August 2016
3 Reads

Leptin as a potential mediator of both physiologic and behavioral determinants of reductions in activity-related energy expenditure during weight loss.

Metabolism 2016 Jan 9;65(1):e1. Epub 2015 Oct 9.

500 Academic Centre, 1020 West Grace Street, Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA, 23284. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2015.10.006DOI Listing
January 2016
4 Reads

Effects of pistachios on the lipid/lipoprotein profile, glycemic control, inflammation, and endothelial function in type 2 diabetes: A randomized trial.

Metabolism 2015 Nov 30;64(11):1521-9. Epub 2015 Jul 30.

Department of Biobehavioral Health, 219 Biobehavioral Health Building, The Pennsylvania State University, University Park, PA, 16802, USA; Department of Nutritional Sciences, 110 Chandlee Laboratory, The Pennsylvania State University, University Park, PA, 16802, USA. Electronic address:

Objective: The health benefits of regular nut consumption have been well-documented; however, effects on cardiovascular risk in diabetes are emerging. This study examined the effects of daily pistachio consumption on the lipid/lipoprotein profile, glycemic control, markers of inflammation, and endothelial function in adults with type 2 diabetes.

Materials/methods: We enrolled 30 adults (40-74 years) with well-controlled type 2 diabetes (mean glycated hemoglobin 6. Read More

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http://dx.doi.org/10.1016/j.metabol.2015.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872503PMC
November 2015
29 Reads

GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice.

Metabolism 2015 Nov 15;64(11):1435-43. Epub 2015 Aug 15.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA; Graduate Center for Nutritional Sciences, Saha Cardiovascular Research Center and Barnstable Brown Kentucky Diabetes and Obesity Center, Lexington, KY, USA. Electronic address:

Objective: Mice lacking leptin (ob/ob) or its receptor (db/db) are obese, insulin resistant, and have reduced levels of biliary cholesterol due, in part, to reduced levels of hepatic G5G8. Chronic leptin replacement restores G5G8 abundance and increases biliary cholesterol concentrations, but the molecular mechanisms responsible for G5G8 regulation remain unclear. In the current study, we used a series of mouse models to address potential mechanisms for leptin-mediated regulation of G5G8. Read More

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http://dx.doi.org/10.1016/j.metabol.2015.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609626PMC
November 2015
8 Reads