702 results match your criteria Nutritional Neuropathy

Precision prognostics for the development of complications in diabetes.

Diabetologia 2022 Jun 21. Epub 2022 Jun 21.

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.

Individuals with diabetes face higher risks for macro- and microvascular complications than their non-diabetic counterparts. The concept of precision medicine in diabetes aims to optimise treatment decisions for individual patients to reduce the risk of major diabetic complications, including cardiovascular outcomes, retinopathy, nephropathy, neuropathy and overall mortality. In this context, prognostic models can be used to estimate an individual's risk for relevant complications based on individual risk profiles. Read More

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MicroRNA-21-5p functions via RECK/MMP9 as a proalgesic regulator of the blood nerve barrier in nerve injury.

Ann N Y Acad Sci 2022 Jun 18. Epub 2022 Jun 18.

Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Center for Interdisciplinary Pain Medicine, Würzburg, Germany.

Both nerve injury and complex regional pain syndrome (CRPS) can result in chronic pain. In traumatic neuropathy, the blood nerve barrier (BNB) shielding the nerve is impaired-partly due to dysregulated microRNAs (miRNAs). Upregulation of microRNA-21-5p (miR-21) has previously been documented in neuropathic pain, predominantly due to its proinflammatory features. Read More

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A review of nutrition in neuropathic pain of leprosy.

Ther Adv Infect Dis 2022 Jan-Dec;9:20499361221102663. Epub 2022 Jun 1.

Tropical Disease Unit, Toronto General Hospital, 200 Elizabeth Street, 13EN-218, Toronto, ON M5G 2C4, Canada.

Leprosy is a neglected tropical disease (NTD) that continues to burden low- and middle-income countries (LMICs), despite being eliminated as a public health concern by the World Health Organization (WHO) in 2000. The causative agents, and , affect nearly 200,000 individuals globally each year, with over 19,000 new cases detected in the Americas in 2020 alone. Canada has experienced an increasing incidence of leprosy, due to rising levels of travel and migration from endemic areas, reaching over 37,000 individuals with leprosy by the end of 2020. Read More

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Movement disorders and neuropathies: overlaps and mimics in clinical practice.

J Neurol 2022 Jun 3. Epub 2022 Jun 3.

Clinical Neurology Unit, "Azienda Socio-Sanitaria Territoriale Santi Paolo E Carlo" and Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142, Milan, Italy.

Movement disorders as well as peripheral neuropathies are extremely frequent in the general population; therefore, it is not uncommon to encounter patients with both these conditions. Often, the coexistence is coincidental, due to the high incidence of common causes of peripheral neuropathy, such as diabetes and other age-related disorders, as well as of Parkinson disease (PD), which has a typical late onset. Nonetheless, there is broad evidence that PD patients may commonly develop a sensory and/or autonomic polyneuropathy, triggered by intrinsic and/or extrinsic mechanisms. Read More

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Effectiveness of a personal health coaching intervention (diabetescoach) in patients with type 2 diabetes: protocol for an open-label, pragmatic randomised controlled trial.

BMJ Open 2022 Jun 1;12(6):e057948. Epub 2022 Jun 1.

Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.

Introduction: The widespread prevalence of type 2 diabetes (T2D) not only influences patients' daily lives but also has an economic impact on society. Increasing physical activity and a healthy diet can delay the progression of T2D. Although there are evidence-based recommendations on diet and physical activity, patients with T2D have difficulties implementing them. Read More

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Optic neuropathy induced by ethambutol: A rare case from Nepal.

Ann Med Surg (Lond) 2022 May 16;77:103637. Epub 2022 Apr 16.

Kist Medical College and Teaching Hospital, Lalitpur, 284403, Nepal.

Introduction: Ethambutol is a drug used against tuberculosis and causes side effects like problems with vision, which may lead to optic neuropathy. It has a low prevalence of 1% and typically develops after 4-12 months of its medications.

Case Presentation: Here, we report a case of a 42-year-old male with ethambutol-induced optic neuropathy after six weeks of initiations of ethambutol. Read More

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Peripheral Neuropathies Derived from COVID-19: New Perspectives for Treatment.

Biomedicines 2022 May 2;10(5). Epub 2022 May 2.

Department of Surgery, Ophthalmology, Otorhinolaryngology and Physiotherapy, Faculty of Medicine, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain.

Peripheral neuropathies constitute a group of disorders affecting the peripheral nervous system. Neuropathies have multiple causes such as infections (i.e. Read More

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An eye for an eye, a tooth for a tooth.

Surv Ophthalmol 2022 May 18. Epub 2022 May 18.

Division of Neuro-Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.

A 77-year-old man presented with the complaint of a painless decrease in vision in both eyes for 1 year. He underwent bilateral cataract surgery without improvement. Neuro-imaging and genetic testing for mitochondrial disease was negative. Read More

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Association between Dietary Inflammatory Index Scores and Diabetes Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus: A Case-Control Study.

Evid Based Complement Alternat Med 2022 21;2022:2661649. Epub 2022 Apr 21.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes sensorimotor polyneuropathy (DSPN) is a common complication of diabetes. Diet has been previously related to DSPN. However, no studies have investigated the relationship between the inflammatory potential of the whole diet and DSPN. Read More

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Combined Nutritional Keratoconjunctivitis Sicca and Optic Neuropathy due to Restrictive Dietary Multivitamin Deficiency of Vitamin C and B12 During the COVID-19 Pandemic.

J Neuroophthalmol 2022 Apr 27. Epub 2022 Apr 27.

McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth) (JZF), Houston, Texas; Department of Ophthalmology (PWM, SR, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medicine, New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; University of Texas MD Anderson Cancer Center (AGL), Houston, Texas; Texas A and M College of Medicine (AGL), UTMB and UT MD Anderson Cancer Center, Bryan, Texas; Department of Ophthalmology (AGL), Baylor College of Medicine and the Center for Space Medicine, The University of Iowa Hospitals and Clinics, Iowa City, Iowa; and University of Buffalo (AGL), Buffalo, NY.

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Gastric cancer complicated by paraneoplastic neurological syndrome which presented with extremity numbness: a case report.

Surg Case Rep 2022 Apr 28;8(1):78. Epub 2022 Apr 28.

Department of Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Background: Paraneoplastic neurological syndromes refer to a group of neurological disorders, which occur as distant effects of malignant tumors and are not caused by metastasis, nutritional disorders, or side effects of antitumor drugs.

Case Presentation: A 70-year-old woman complained of a 1-month history of extremity numbness. Upon presentation to our hospital, she had worsening numbness, and experienced staggering and falling. Read More

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Schwann cell necroptosis in diabetic neuropathy.

Proc Natl Acad Sci U S A 2022 04 21;119(17):e2204049119. Epub 2022 Apr 21.

Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01069 Dresden, Germany.

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Vitamin B6 deficiency as a cause of polyneuropathy in POEMS syndrome: rapid recovery with supplementation in two cases.

Hematology 2022 Dec;27(1):463-468

Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan.

Background: The etiology of POEMS syndrome and its associated polyneuropathy have not been fully elucidated. The clinical picture of POEMS-associated polyneuropathy and nutritional polyneuropathy due to vitamin B6 (VB6) deficiency are strikingly similar, both being typically sensorimotor, symmetrical, stocking and glove distribution, and more severe in the lower extremities.

Case Presentation: We report two consecutive POEMS patients with VB6 deficiency who showed unusual rapid and drastic recovery of polyneuropathies within 6-8 weeks after oral VB6 supplementation. Read More

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December 2022

Editorial: Management of Diabetes and its Complications: A Focus on Endothelial Dysfunction.

Front Endocrinol (Lausanne) 2022 18;13:857983. Epub 2022 Mar 18.

Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, SA, Australia.

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Homo-AMPA in the periaqueductal grey modulates pain and rostral ventromedial medulla activity in diabetic neuropathic mice.

Neuropharmacology 2022 07 29;212:109047. Epub 2022 Mar 29.

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli", Naples, Italy; IRCSS, Neuromed, Pozzilli, Italy.

The 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)-butyric acid, homo-AMPA, an analog of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and 2-aminoadipic acid, has shown no activity towards ionotropic and metabotropic glutamate 1, 2, 3, 4, 5, and 7 receptors (mGluR1-7), agonist activity at mGluR6 while the activity at mGluR8 was never investigated. The effect of homo-AMPA on pain control has been never investigated. In this study we evaluated the effect of intra-ventrolateral periaqueductal grey (VL PAG) microinjections of homo-AMPA on pain responses and the activity of pain-responding neurons of the rostral ventromedial medulla (RVM), the "pronociceptive" ON cells, and the "antinociceptive" OFF cells. Read More

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Synthesis and evaluation of wound healing properties of hydro-diab hydrogel loaded with green-synthetized AGNPS: in vitro and in ex vivo studies.

Drug Deliv Transl Res 2022 Mar 31. Epub 2022 Mar 31.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, CS, Italy.

In diabetic patients, the presence of neuropathy, peripheral vascular diseases and ischemia, leads to the formation of foot ulcerations with a higher risk of infection because the normal response to bacterial infection is missing. In the aim to control and treat diabetic foot ulcerations (DFUs), wound dressings that are able to absorb exudate, to prevent infections, and to promote wound healing are needed. For this reason, the aim of the present research was to synthetize a biocompatible hydrogel (called HyDrO-DiAb) composed of carboxymethylcellulose loaded with silver nanoparticles (AgNPs) for the treatment of diabetic foot ulcers. Read More

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Visual field decline and restoration following vitamin A therapy for vitamin A deficiency.

Am J Ophthalmol Case Rep 2022 Jun 5;26:101471. Epub 2022 Mar 5.

Southeastern Retina Specialists, 7740 Point Meadows Dr., Jacksonville, FL, USA.

Purpose: To present a case of nutritional vitamin A deficiency (VAD) that caused bilateral severe dry eye symptoms and progressive visual field contraction over a 13.5-month span resulting in peripheral blindness and nyctalopia, and to document the patient's rapid visual field restoration following vitamin A therapy (VAT).

Observations: A 34-year-old Haitian woman presented for a glaucoma consultation with the following symptoms in both eyes (OU): painful dry eyes, floaters, nyctalopia, and visual field contraction over eighteen months despite treatment with four anti-glaucoma medications and intraocular pressures (IOP) in the low teens OU. Read More

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Toxic and Nutritional Optic Neuropathies-An Updated Mini-Review.

Int J Environ Res Public Health 2022 03 6;19(5). Epub 2022 Mar 6.

Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland.

Optic neuropathies constitute a group of conditions with various etiologies and might be caused by different factors; we can distinguish the genetic and acquired causes of optic neuropathies. Even though the symptoms are not highly specific, this condition is primarily characterized by unilateral or bilateral vision loss with worsening color detection. The loss may be acute or gradual depending on the causation. Read More

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Narrative Review of the Relationship Between CKD and Diabetic Foot Ulcer.

Kidney Int Rep 2022 Mar 21;7(3):381-388. Epub 2021 Dec 21.

Transversal Nutrition Unit, Endocrinology-Diabetes-Nutrition Department, University Hospital of Montpellier, Montpellier, France.

Diabetic foot ulcer (DFU) and chronic kidney disease (CKD) are 2 significant complications of diabetes mellitus (DM). Up to 40% of patients with DM are expected to also develop CKD, and 19% to 34% will suffer from DFU during their lifetimes. However, data on the link between podiatric risk and the extent of CKD are scarce. Read More

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Kampo medicines for supportive care of patients with cancer: A brief review.

Integr Med Res 2022 Jun 23;11(2):100839. Epub 2022 Feb 23.

Clinic for Gastroenterology and Gastrointestinal Oncology, University of Göttingen Medical School, Göttingen, Germany.

Background: Kampo medicines, which are standardized traditional Japanese herbal medicines, have been tried to support patients with cancer.

Methods: Randomized controlled trials on the use of Kampo medicines for cancer supportive care and the descriptions of Kampo medicines in clinical practice guidelines were reviewed.

Results: Kampo medicines potentially ameliorate refractory symptoms in cancer patients. Read More

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Patisiran treatment in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy after liver transplantation.

Am J Transplant 2022 Jun 26;22(6):1646-1657. Epub 2022 Mar 26.

Neurology Department, Université Paris-Saclay, U1195, INSERM, Le Kremlin Bicêtre, France.

Hereditary transthyretin-mediated (hATTR) amyloidosis, or ATTRv amyloidosis, is a progressive disease, for which liver transplantation (LT) has been a long-standing treatment. However, disease progression continues post-LT. This Phase 3b, open-label trial evaluated efficacy and safety of patisiran in patients with ATTRv amyloidosis with polyneuropathy progression post-LT. Read More

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Bitemporal peripapillary hemorrhages: Toxic-ischemic optic neuropathy caused by ethanol and cocaine abuse.

Am J Ophthalmol Case Rep 2022 Mar 3;25:101374. Epub 2022 Feb 3.

Department of Ophthalmology, University General Hospital of Castellón, Avenida de Benicàssim, 128, 12004, Castellón de La Plana, Spain.

A 36-year-old man presented complaining of bilateral painless vision loss. He was admitted with chronic ethanol abuse, as well as sporadic cocaine consumption three days before symptom onset. General medical evaluation dismissed cerebral and cardiovascular events. Read More

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Beriberi Neuropathy Mimicking Guillian-Barre Syndrome in a Teenager With Food Restriction: A Case Report.

Cureus 2022 Jan 19;14(1):e21417. Epub 2022 Jan 19.

Child Neurology and Neurodevelopmental Disabilities, West Virginia University Medicine, Morgantown, USA.

Beriberi neuropathy (thiamine deficiency) and Guillian-Barre Syndrome (GBS) both can present with areflexia and progressive ascending weakness. A physical examination can be equivocal between the two. In cases where GBS is suspected clinically but initial work-up with cerebral spinal fluid (CSF) studies and magnetic resonance imaging (MRI) of the spine are not diagnostic, nerve conduction study/electromyography (NCS/EMG) should be done to evaluate beriberi neuropathy. Read More

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January 2022

The 'i' in nutrition: Paediatric nutritional optic neuropathy secondary to avoidant/restrictive food intake disorder and multi-micronutrient deficiency.

J Paediatr Child Health 2022 Feb 8. Epub 2022 Feb 8.

Department of General Paediatrics, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

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February 2022


Cesk Slov Oftalmol 2021 ;77(3):147-150

The most common cause of visual field loss in ophthalmology is glaucoma. Other causes of visual field damage include local damage to the eye itself in intrabulbar or retrobulbar neuritis or injuries. However, they can also be caused by general diseases, e. Read More

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February 2022

Decompensated Superior Oblique Palsy Secondary to Bilateral Nutritional Optic Neuropathy Following Bariatric Surgery.

Case Rep Ophthalmol 2021 Sep-Dec;12(3):1008-1013. Epub 2021 Dec 30.

Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel.

Optic neuropathy can occur secondary to nutritional deficiencies in patients who have undergone bariatric surgery. We present a unique case of a 39-year-old man, claiming to be generally healthy, who presented with intermittent vertical diplopia and bilateral decreased vision in each eye. Visual acuity was 6/18 in the right eye and 6/12 in the left eye. Read More

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December 2021

Nutritional optic neuropathy: Diagnostic dilemma.

Indian J Ophthalmol 2022 02;70(2):706

Neuro-Ophthalmology Clinic and Glaucoma Service, AG Eye Hospital, Trichy, Tamil Nadu, India.

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February 2022

Post-COVID Wernicke's presenting as bilateral vision loss.

Am J Ophthalmol Case Rep 2022 Mar 20;25:101271. Epub 2022 Jan 20.

Rush University Medical Center, 1725 W Harrison St, Chicago, IL, USA.

Purpose: This case report represents poor nutritional intake and vomiting secondary to COVID-19 resulting in Wernicke's syndrome and blindness.

Observations: We report the case of a 36 year old with a post-COVID episode of acute-subacute onset bilateral blindness ultimately diagnosed as Wernicke's syndrome based on MRI findings and clinical response to high dose IV thiamine supplementation.

Conclusions And Importance: Given this patient's dramatic presentation of no light perception vision in both eyes and resolution of symptoms with treatment, it is reasonable to consider thiamine deficiency in any individual who presents with acute-subacute onset vision loss, particularly when the history is suggestive of potential nutritional deficiency. Read More

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A Systematic Review of Nutritional Lab Correlates with Chemotherapy Induced Peripheral Neuropathy.

J Clin Med 2022 Jan 12;11(2). Epub 2022 Jan 12.

Mayo Clinic Libraries, Mayo Clinic, Jacksonville, FL 32224, USA.

Chemotherapy induced peripheral neuropathy (CIPN) is a dose-limiting side effect of chemotherapy for which no prevention or cure exists. Cancer and cancer treatments can adversely affect nutritional status. Nutrition may play a role in development of CIPN, yet the relationship between nutrition and CIPN is not well understood. Read More

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January 2022

Rehabilitation of COVID-19 patients with respiratory failure and critical illness disease in Slovenia: an observational study.

Int J Rehabil Res 2022 Mar;45(1):65-71

University Rehabilitation Institute.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes pneumonia and respiratory failure that may lead to postintensive care syndrome, including critical illness neuropathy (CIN) and critical illness myopathy (CIM). The data on the rehabilitation outcomes of post-novel coronavirus disease (COVID) patients with CIN and CIM following respiratory failure and mechanical ventilation are still limited. To address this, we enrolled in our prospective observational study a sample of 50 consecutive COVID-19 patients admitted to our facility between 2 November 2020 and 3 May 2021 with electrophysiologically confirmed or clinically suspected diagnosis of CIN/CIM. Read More

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