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Dis Markers 2020 19;2020:1694218. Epub 2020 May 19.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Peripheral neuropathy is a common neurological complication in uremic patients, and quantitative sensory testing (QST) is effective for diagnosis of small fiber neuropathy. Malnutrition and arterial stiffness are prevalent in patients undergoing hemodialysis (HD). The associations of small fiber neuropathy with nutritional status and arterial stiffness remain uncertain in maintenance HD patients. Read More

Medicine (Baltimore) 2020 May;99(21):e20461

Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine.

Background: Diabetic gastroparesis (DG) is a common autonomic neuropathy which impacts on nutritional state and quality of life in diabetic patients, and it also adversely affects glycemic control in diabetes. The prevalence of DG is growing with the number of patients with diabetes continues to increase. However, there is no definitive answer as to which of the current therapies is the best for the clinical treatment of the different manifestations of DG. Read More

J Neuroophthalmol 2020 Apr 15. Epub 2020 Apr 15.

Departments of Ophthalmology and Vision Sciences (PF, EM), and Medical Imaging (LA-S), Faculty of Medicine, University of Toronto, Toronto, Canada; Department of Biomedical Physics (GM), Ryerson University, Toronto, Canada; Department of Laboratory Medicine (DH), University of Toronto, Toronto, Canada.

A 70 year-old man presented with insidiously progressing central visual acuity loss in both eyes over several years. Objectively the only abnormality identified on the exam was questionable granularity in the fovea in each eye. Extensive work up which included neuro-imaging, screening blood work for toxic and nutritional causes of optic neuropathy as well as electroretinogram and fluorescein angiography to rule out subtle maculopathy was all unrevealing. Read More

J Foot Ankle Res 2020 May 19;13(1):26. Epub 2020 May 19.

Diabetes, Obesity and Nutrition Strategic Clinical Network, Alberta Health Services, 10101 Southport Road, Calgary, Alberta, T2W 1S7, Canada.

Background: Neuropathy and vasculopathy can lead to costly and debilitating complications in people with diabetes. The purpose of this study was to evaluate, at an organizational level, uptake of practices included in a diabetic foot care clinical pathway and associated resources. This research focused on patients at low and moderate risk in Alberta, Canada between 2014 to 2019. Read More

Curr Mol Pharmacol 2020 May 12. Epub 2020 May 12.

Post Graduate Institute of Medical Education and Research, Chandigarh. India.

Background: Alcoholic neuropathy is a chronic disorder caused by excessive consumption of alcohol. Damage to the nerves results in unusual sensations in the limbs, decrease mobility and loss of some body functions.

Objective: Alcohol is considered a major villain for exclusively creating the debilitating condition of the neuropathic state. Read More

J Clin Neurosci 2020 Apr 29. Epub 2020 Apr 29.

USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States. Electronic address:

A 22-year old male with a history of B-cell acute lymphoblastic leukemia with recent bone marrow transplantation and on immunosuppressive therapy presented with painless, subacute vision loss of two weeks duration. He exhibited a horizontal gaze palsy, nystagmus, and mildly swollen and hyperemic optic discs with peripapillary flame hemorrhage on retinal exam. He had bilateral cecocentral scotomas on visual field exam, and MRI of his brain/orbits demonstrated hyperintensities in the hypothalamus, periaqueductal gray, and dorsal rostral medullary regions. Read More

Am J Trop Med Hyg 2020 Apr 13. Epub 2020 Apr 13.

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Identification of DNA by polymerase chain reaction (PCR) is a reliable and an affordable method to confirm leprosy. DNA from 87 nerve samples (56 from paraffin blocks and 26 fresh samples) was extracted. DNA was amplified by PCR from 80/87 (92%) specimens. Read More

Neurol Ther 2020 Jun 31;9(1):135-149. Epub 2020 Mar 31.

Pfizer Inc, Groton, CT, USA.

Introduction: Hereditary (variant) transthyretin amyloidosis (ATTRv) with polyneuropathy (ATTR-PN) is a rare genetic disorder that causes progressive autonomic and sensorimotor neuropathy, severe disability, and death within 10 years of onset. Previous studies have primarily focused on how baseline cardiac characteristics affect mortality, but the impact of non-cardiac baseline characteristics is less defined.

Methods: We systematically searched PubMed/Medline (1990-2019) to identify studies that assessed the impact of baseline ATTR-PN characteristics on survival. Read More

Front Cell Dev Biol 2020 4;8:121. Epub 2020 Mar 4.

Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, Rende, Italy.

Autophagy is a conserved lysosomal-dependent pathway responsible for the degradation of cytoplasmic macromolecules. Based on the mechanism of cargo delivery to lysosomes, mammalian cells can undergo micro, macro, and chaperone-mediated autophagy. Other than physiological turnover of proteins and organelles, autophagy regulates cellular adaptation to different metabolic states and stressful conditions by allowing cellular survival or, when overactivated, participating to cell death. Read More

Nutrients 2020 Mar 9;12(3). Epub 2020 Mar 9.

Instituto Oftalmológico Fernández-Vega, Avda. Dres. Fernández-Vega, 34, 33012 Oviedo, Spain.

Nutritional supplementation with antioxidants and vitamins is widely recommended in the treatment of vascular disorders affecting the retina, although there is insufficient evidence on its effectiveness. The vitamin-like compound coenzyme Q10 (CoQ10) is a nutritional supplement of current interest to treat neurodegenerative diseases. Here, we report a retrospective clinical case series study of 48 patients diagnosed with retinal vascular diseases, including non-arteritic ischemic optic neuropathy (NAION), retinal artery occlusion (RAO), and homonymous hemianopia or quadrantanopia following stroke, treated with oral supplementation with CoQ10 (100 mg per day) and vitamins. Read More

Cell 2020 Mar 10;180(6):1160-1177.e20. Epub 2020 Mar 10.

Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Biology, ETH Zürich, 8093 Zürich, Switzerland. Electronic address:

Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but is poorly understood beyond a few autophagosomal receptors and remodelers. By using an ER-phagy reporter and genome-wide CRISPRi screening, we identified 200 high-confidence human ER-phagy factors. Read More

Biofactors 2020 May 21;46(3):411-420. Epub 2020 Jan 21.

Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Punjab, India.

Diabetic neuropathy is a peripheral nervous system disorder affecting both somatic and autonomic components of nervous system. A growing body of evidence have depicted that high glucose levels can induce activation of the Wnt/β-catenin pathway, however there are no studies targeting this pathway in DN. The intent of the present study was to investigate the effects of isoquercitrin (ISQ), a Wnt/β-catenin signaling pathway inhibitor, in diabetic neuropathy. Read More

J Neurol Sci 2020 Feb 20;409:116583. Epub 2019 Nov 20.

Department of Neurology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA. Electronic address:

Objectives: To evaluate the odds of vitamin B12 and folate deficiencies among Zambian clinic attendees with distal symmetric polyneuropathy (DSP) and age, sex, and HIV matched controls.

Methods: Cases were adults from clinics in urban/peri-urban Zambia. Controls were enrolled among persons not seeking personal medical care, such as a caregiver or person collecting antiretrovirals without a medical complaint. Read More

Muscle Nerve 2020 Jul 26;62(1):13-29. Epub 2019 Dec 26.

University of Virginia, Charlottesville, Virginia.

Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length-dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the exception, often presenting with a non-length-dependent sensory neuropathy. Read More

Biomed Res Int 2019 11;2019:8397521. Epub 2019 Nov 11.

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.

Retinal ganglion cell (RGC) death is the central and irreversible endpoint of optic neuropathies. Current management of optic neuropathies and glaucoma focuses on intraocular pressure-lowering treatment which is insufficient. As such, patients are effectively condemned to irreversible visual impairment. Read More

Horm Metab Res 2019 Dec 11;51(12):779-784. Epub 2019 Dec 11.

Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.

As the rate of obesity and the incidence of diabetes mellitus have been increasing, diabetic neuropathy has become the most common cause of peripheral neuropathy in developed countries. In addition, a variety of pathogenetically heterogeneous disorders can lead to impairment of the peripheral nervous system including amyloidosis, vitamin deficiencies, uremia and lipid disorders, alcohol abuse, autoimmune and infectious diseases as well as exposure to environmental toxins. We have noted that a combination of these disorders may aggravate the manifestations of peripheral diabetic neuropathy, an effect, which is most pronounced when metabolic and non-metabolic pathologies lead to cumulative damage. Read More

Metab Brain Dis 2020 01 4;35(1):65-74. Epub 2019 Dec 4.

Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa, 91000, Veracruz, Mexico.

Cassava (Manihot esculenta Crantz) is a tropical plant that is used as fresh food, processed food, or raw material for the preparation of flours with high nutritional value. However, cassava contains cyanogenic glycosides, such as linamarin and lotaustralin, that can trigger severe toxic effects and some neurological disorders, including motor impairment, cognitive deterioration, and symptoms that characterize tropical ataxic neuropathy and spastic epidemic paraparesis (Konzo). These alterations that are associated with the consumption of cassava or its derivatives have been reported in both humans and experimental animals. Read More

Phytother Res 2020 Apr 1;34(4):896-903. Epub 2019 Dec 1.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Depression in patients with diabetes is associated with poor glycemic control and linked to an increased risk for diabetes complications such as neuropathy. Curcumin has shown potential antidepressant-like activities in some studies. The present study is the first randomized controlled trial to test the efficacy of nano-curcumin supplementation on depression, anxiety, and stress in patients with diabetic polyneuropathy. Read More

J Med Case Rep 2019 Nov 18;13(1):336. Epub 2019 Nov 18.

Department of Medicine and Aged Care, The Royal Melbourne Hospital, Parkville, VIC, Australia.

Background: Subacute combined degeneration of the spinal cord is a potentially reversible myelopathy typically associated with vitamin B12 deficiency. There is predominant involvement of spinal cord posterior and lateral tracts, and manifestations include peripheral paraesthesia, impaired proprioception, gait disturbance, neuropathy and cognitive changes. Motor neuron disease (MND) is an unremittingly progressive neurodegenerative disorder involving upper and lower motor neurons with an average prognosis of 2-3 years. Read More

J Neurol 2020 Mar 14;267(3):703-712. Epub 2019 Nov 14.

AP-HP, Université Paris Saclay, CHU Bicêtre, Université Paris-Sud, INSERM 1195, Paris, France.

Hereditary transthyretin-mediated (hATTR) amyloidosis is a progressive, debilitating disease often resulting in early-onset, life-impacting autonomic dysfunction. The effect of the RNAi therapeutic, patisiran, on autonomic neuropathy manifestations in patients with hATTR amyloidosis with polyneuropathy in the phase III APOLLO study is reported. Patients received patisiran 0. Read More

Arch Physiol Biochem 2019 Nov 5:1-13. Epub 2019 Nov 5.

Modern College of Pharmacy, Nigdi, India.

is a rich source of nutritional food with acclaimed therapeutic uses. Banana pulp has been reported to possess antidiabetic properties. The present study aimed to investigate antidiabetic potential of peels and its fractions along with diabetic complications. Read More

Semin Neurol 2019 10 22;39(5):651-668. Epub 2019 Oct 22.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.

Peripheral neuropathy is associated with numerous systemic diseases. It is often the heralding finding, which can lead to earlier diagnoses and better outcomes. An understanding of the epidemiology and clinical features of these diseases is paramount to their diagnosis and management. Read More

Altern Ther Health Med 2019 Oct 1. Epub 2019 Oct 1.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common troublesome side effect and affects long-term activities of daily living. This neuropathic disorder is still difficult to treat with current clinical treatments. The aim of this study was to investigate and offer an updated perspective of complementary therapies for CIPN. Read More

Diabet Med 2020 01 13;37(1):95-104. Epub 2019 Nov 13.

Diabetic Foot Clinic, King's College Hospital NHS Foundation Trust, London, UK.

Aim: To assess the usefulness of monthly thermography and standard foot care to reduce diabetic foot ulcer recurrence.

Methods: People with diabetes (n = 110), neuropathy and history of ≥ 1 foot ulcer participated in a single-blind multicentre clinical trial. Feet were imaged with a novel thermal imaging device (Diabetic Foot Ulcer Prevention System). Read More

PLoS One 2019 10;14(10):e0223000. Epub 2019 Oct 10.

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.

Background: Vitamin B-12 deficiency is often considered synonymous with pernicious anemia, a rare condition in which severe malabsorption of the vitamin requires high-dose parenteral treatment. In developing countries such as India, inadequate dietary intake of B-12 due to socio-cultural factors leads to widely prevalent asymptomatic low B-12 status. In this scenario, lower doses of oral B-12 may be effective, safer and more affordable. Read More

Continuum (Minneap Minn) 2019 Oct;25(5):1265-1288

Purpose Of Review: The diagnosis of visual loss from toxic-metabolic and hereditary optic neuropathies may be delayed in some cases because of a failure to elicit important information in the clinical history or to recognize typical examination findings. An understanding of the features specific to each type of toxic-metabolic and hereditary optic neuropathy, and of the underlying mechanism of insult to the optic nerve, could lead to earlier recognition, diagnosis, and treatment (when available).

Recent Findings: Understanding of the role of mitochondria in toxic-metabolic and hereditary optic neuropathies is growing, particularly regarding the mechanism of insult of certain agents (medications and toxins) and of vitamin B12 deficiency. Read More

Rev Neurol (Paris) 2019 Dec 18;175(10):631-640. Epub 2019 Sep 18.

Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA. Electronic address:

The consumption by humans of plants with potential to induce neurological disorders is widespread, but overt disease surfaces only when the subject's toxic threshold is exceeded. Excessive intake arising from food dependency in the setting of hunger, chronic undernutrition, vitamin deficiency, inadequate detoxication, or other individual susceptibility, can trigger acute encephalopathy (lychee, ackee fruits), sub-acute spastic paraparesis (grasspea, cassava root/leaves) or ataxic neuropathy (cassava root flour). While these disorders are very rarely encountered in high-income countries, they are not only common among impoverished populations but also often occur as outbreaks that impact a significant proportion of an affected community. Read More

Pediatr Hematol Oncol 2019 Sep 13;36(6):344-351. Epub 2019 Sep 13.

Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children's Hospital , New Delhi , India.

Injection vincristine is an important component of therapy for acute lymphoblastic leukemia (ALL). An important adverse effect of vincristine is neurotoxicity. The incidence of this adverse effect is well studied. Read More

Cureus 2019 Jul 8;11(7):e5098. Epub 2019 Jul 8.

Internal Medicine, Crouse Hospital, Syracuse, USA.

Bariatric surgery is recognized as a highly effective therapy for obesity but it does carry a risk of short term and long term complications since it results in a permanent alteration of the patient's anatomy. We present a case of 45-year-old female presented with a macular rash on extremities and facial rash from a rehabilitation center after having been discharged a month earlier from a revision surgery on her gastric bypass for anastomotic bleeding. She progressively became lethargic with Magnetic Resonance Imaging (MRI) of the brain showed symmetrically restricted diffusion concerning for hypoxic injury. Read More

Clin Auton Res 2019 09 31;29(Suppl 1):1-9. Epub 2019 Aug 31.

Department of Neurology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Co. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City, 14080, Mexico.

Background: Autonomic dysfunction is a hallmark feature of hereditary ATTR amyloidosis. The aim of this study was to summarize the characteristics and natural history of autonomic dysfunction in patients with hereditary ATTR amyloidosis.

Methods: A systematic review of the natural history and clinical trials of patients with ATTR amyloidosis was performed. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Nov 7;128(5):e180-e186. Epub 2019 Aug 7.

Private Practice, Bethesda, MD, USA.

There are multiple reasons for failure of full maxillary dentures. It is necessary for clinicians to consider the rationale behind the failure of the prosthesis before remaking a maxillary full denture. Diagnostic categories related to pertinent maxillofacial and oral neuropathies and psychosocial issues are also discussed. Read More

Clin Auton Res 2019 09 9;29(Suppl 1):11-17. Epub 2019 Aug 9.

Department of Neurosciences and Mental Health, CHULN, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.

Purpose: Transthyretin-mediated hereditary amyloidosis (hATTR amyloidosis) is a multisystemic disease with heterogeneous clinical presentation. Hallmarks of the disease are sensory-motor and autonomic neuropathy and cardiomyopathy. Two disease-modifying drugs, inotersen (an antisense oligonucleotide) and patisiran (a small interfering RNA agent), were recently approved for the treatment of hATTR polyneuropathy. Read More

Alcohol Clin Exp Res 2019 10 23;43(10):2144-2152. Epub 2019 Aug 23.

Department of Psychiatry and Behavioral Sciences, (NMZ, KMP, AP, EVS), Stanford University School of Medicine, Stanford, California.

Background: Among the neurological consequences of alcoholism is peripheral neuropathy. Relative to human immunodeficiency virus (HIV) or diabetes-related neuropathies, neuropathy associated with alcohol use disorders (AUD) is understudied. In both the diabetes and HIV literature, emerging evidence supports a central nervous system (CNS) component to peripheral neuropathy. Read More

Neuropediatrics 2019 12 22;50(6):341-345. Epub 2019 Jul 22.

ENT Unit, Department of Otorhinolaryngology, University of Catania, Italy.

Optic neuropathy consists of several etiological events. The primary etiologies of its acute form include optic neuritis, ischemic optic neuropathy, inflammatory (nondemyelinating) disorders, and trauma. Its subacute and chronic forms are most often linked to compressive, toxic, nutritional, or hereditary-genetic causes. Read More

Nutr Neurosci 2019 Jul 7:1-13. Epub 2019 Jul 7.

a Department of Metabolism and Nutrition, Graduate School of Medicine and Pharmaceutical Science for Research , University of Toyama , Toyama , Japan.

Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that mediates various redox reactions. Particularly, mitochondrial NAD plays a critical role in energy production pathways, including the tricarboxylic acid (TCA) cycle, fatty acid oxidation, and oxidative phosphorylation. NAD also serves as a substrate for ADP-ribosylation and deacetylation by poly(ADP-ribose) polymerases (PARPs) and sirtuins, respectively. Read More

Hum Mol Genet 2019 11;28(22):3792-3804

Institut de Biochimie et Génétique Cellulaires, Université Victor Segalen, 1 Rue Camille Saint-Saëns, CEDEX 33077 Bordeaux, France.

The m.8993T>G mutation of the mitochondrial MT-ATP6 gene has been associated with numerous cases of neuropathy, ataxia and retinitis pigmentosa and maternally inherited Leigh syndrome, which are diseases known to result from abnormalities affecting mitochondrial energy transduction. We previously reported that an equivalent point mutation severely compromised proton transport through the ATP synthase membrane domain (FO) in Saccharomyces cerevisiae and reduced the content of cytochrome c oxidase (Complex IV or COX) by 80%. Read More

Maturitas 2019 Aug 14;126:69-72. Epub 2019 May 14.

Division of Endocrinology and Diabetes, Second Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

As type 2 diabetes mellitus (T2DM) is affected by both chronological and ovarian ageing, it is common in postmenopausal women. This review analyses and critically appraises the literature regarding the optimal therapeutic strategies for T2DM in women after menopause. Lifestyle interventions, including changes in dietary habits and physical exercise in everyday life targeting a modest weight loss (5%), represent the cornerstone of management. Read More

Am J Phys Med Rehabil 2020 03;99(3):e32-e34

From the Department of Physical Medicine & Rehabilitation, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Although generally presenting as a chronic, progressive peripheral neuropathy, we present a case of acute alcoholic neuropathy initially mistaken for acute Guillain-Barré syndrome. Electrodiagnostic evaluation of alcoholic neuropathy reveals an axonal neuropathy and may be complicated by demyelination if comorbid nutritional deficiencies are present. This is in contrast to the significant demyelination classically associated with Guillain-Barré syndrome. Read More

Obes Surg 2019 10;29(10):3404-3405

Department of Gastroenterology, Section of Advanced Endoscopy, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.

Endoscopic bariatric therapies (EBTs) are emerging as nonsurgical weight loss interventions that are being used with increasing frequency. Similar to the potential for early and late complications from bariatric surgeries, metabolic derangements and nutritional deficiencies can also be seen after EBTs. In particular, thiamine deficiency is a well-known complication typically presenting with neurological symptoms, commonly Wernicke encephalopathy or dry beriberi. Read More

Int J Vitam Nutr Res 2019 May 24:1-14. Epub 2019 May 24.

1 Institute of Home Economics, University of Delhi, India.

Vitamin E is a lipid soluble antioxidant which mainly circulates as α-tocopherol in the human plasma. Its deficiency is associated with ataxia, neuropathy, anaemia and several other health conditions. Although substantial data on vitamin E status has been published worldwide, there is paucity of data on the extent of deficiency from most Asian countries, including India. Read More

Ann Intensive Care 2019 May 17;9(1):57. Epub 2019 May 17.

SC Anestesia e Rianimazione, Ospedale San Paolo - Polo Universitario, ASST Santi Paolo e Carlo, Milan, Italy.

Muscular weakness developing from critical illness neuropathy, myopathy and muscle atrophy has been characterized as intensive care unit-acquired weakness (ICUAW). This entity occurs commonly during and after critical care stay. Various causal factors for functional incapacity have been proposed. Read More

Endocr Rev 2019 10;40(5):1318-1352

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

This review covers the epidemiology, pathophysiology, clinical features, diagnosis, and management of diabetic gastroparesis, and more broadly diabetic gastroenteropathy, which encompasses all the gastrointestinal manifestations of diabetes mellitus. Up to 50% of patients with type 1 and type 2 DM and suboptimal glycemic control have delayed gastric emptying (GE), which can be documented with scintigraphy, 13C breath tests, or a wireless motility capsule; the remainder have normal or rapid GE. Many patients with delayed GE are asymptomatic; others have dyspepsia (i. Read More

Muscle Nerve 2019 08 30;60(2):124-136. Epub 2019 May 30.

Wellness and Integrative Neurology, Advanced Pain and Anesthesia Consultants, Centers for Pain Management, Westchester, Illinois, USA.

Complementary and alternative treatment modalities are commonly utilized by patients for neuropathy and neuropathic pain due to perceived lack of benefit from conventional medical treatment. As the association between metabolic syndrome and neuropathy is increasingly recognized, diet and lifestyle interventions are becoming important components in the management of neuropathy. Progress in the understanding of the gut-immune interaction highlights the role the gut microbiome and inflammation plays in the modulation of neuropathy and neuropathic pain. Read More

Diabetol Metab Syndr 2019 2;11:34. Epub 2019 May 2.

1Programa de Pós-Graduação em Endocrinologia, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, Prédio 21, 6º andar, Porto Alegre, RS 90035-003 Brazil.

Background: This study was developed to evaluate quality indicators in type 2 diabetes patient care at the Unified Public Health System's primary and tertiary health care centers within a local population.

Methods: This was a retrospective cohort of 488 patients with type 2 diabetes (148 in each primary health care unit, ESF and UBS, and 192 at the tertiary health care unit) with a 1-year follow-up to evaluate the following care quality indicators: nephropathy, neuropathy and retinopathy tests, yearly lipid profile and nutritional assessments, and an inquiry about tobacco use. The presence of > 50% of the quality of care assessment measures was considered acceptable. Read More

J Pain Symptom Manage 2019 08 30;58(2):252-263. Epub 2019 Apr 30.

School of Nursing, University of California, San Francisco, California, USA. Electronic address:

Context: Recent, albeit, limited evidence suggests that body mass index (BMI) may be a modifiable risk factor to reduce the deleterious effects of chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors.

Objectives: To evaluate for differences in demographic, clinical, pain, sensation, and balance characteristics among three BMI groups. We hypothesized that as BMI increased, survivors would report higher pain intensity scores and have significant decrements in measures of sensation and balance. Read More

Nutr Hosp 2019 Jul;36(3):743-747

Department of Surgery. Faculty of Medical Sciences. Universidade Estadual de Campinas (UNICAMP).

Introduction: Case report: we present the case of a 44-year-old male who presented with uncontrollable diarrhea, severe protein-calorie malnutrition and multiple vitamin deficiencies, along with peripheral neuropathy ten years after classic biliopancreatic diversion (BPD). He underwent nutritional support and had the surgery converted to a Roux-en-Y gastric bypass, with an uneventful outcome. The histopathology of the resected bowel revealed lipofuscinosis of the muscular layer compatible with brown bowel syndrome. Read More

Complement Ther Med 2019 Apr 28;43:253-260. Epub 2019 Feb 28.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Diabetic Sensorimotor Polyneuropathy (DSPN) is a common complication of diabetes mellitus. Curcumin is the most important ingredient found in turmeric which has a very high potential for eliminating free radicals and inhibiting oxidative stress as an antioxidant agent. The aim of this study was to determine the effect of Nano-curcumin supplementation on the severity of sensorimotor polyneuropathy in patients with Type 2 diabetes mellitus (T2DM). Read More

Behav Brain Res 2019 07 27;367:201-209. Epub 2019 Mar 27.

Neuroscience, Pharmacology and Environment Unit (ENPE), faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco. Electronic address:

Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome resulting from acute or chronic hepatic impairments. The clinical features of HE include attention as well as a mild cognitive deficits associated with impaired attentional and executive networks in patients as well as in animal models of HE. The underlining pathomechanism of memory impairment in HE patients is still not fully understood; however, it may involve a possible gliopathy as well as neuropathy. Read More