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Nutr Cancer 2019 Apr 22:1-12. Epub 2019 Apr 22.

b Division of Gastroenterology Hepatology and Nutrition , University of Pittsburgh , Pittsburgh , Pennsylvania , USA.

The incidence of colorectal cancer (CRC) is gradually rising in sub-Saharan Africa. This may be due to dietary changes associated with urbanization, which may induce tumor-promoting gut microbiota composition and function. We compared fecal microbiota composition and activity in 10 rural and 10 urban Zimbabweans for evidence of a differential CRC risk. Read More

Nutr Cancer 2019 Apr 22:1-14. Epub 2019 Apr 22.

a University of Arkansas for Medical Sciences , Little Rock , Arkansas , USA.

This is a case-cohort study to examine whether the excess of liver cancer deaths observed in workers in poultry plants could be explained by oncogenic viruses and chemical carcinogenic exposures within the plants. A detailed telephone questionnaire was administered, and responses were analyzed by logistic regression. Odds ratios for several indicators of high exposure to oncogenic viruses or chemical carcinogens in poultry plants and related industries were elevated, but not statistically significant, except the odds ratio for direct contact with the blood of meat in kitchens, eating places, etc. Read More

Nutr Cancer 2019 Apr 22:1-10. Epub 2019 Apr 22.

e Department of Clinical Oncology, College of Korean Medicine , Kyung Hee University , Seoul , Republic of Korea.

Medical records of patients with advanced non-small cell lung cancer (NSCLC) were retrospectively reviewed to examine the prognostic impact of nutritional status on survival. Age, sex, body mass index (BMI), Eastern Cooperative Oncology Group Performance Status (ECOG-PS), histologic tumor type, pulmonary comorbidities, white blood cell (WBC) count, C-reactive protein (CRP) level, and prognostic nutritional index (PNI) were assessed. Overall survival was calculated using Kaplan-Meier analysis and compared using log-rank testing. Read More

Nutr Cancer 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Cancer Research Center Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Background: Breast cancer (BrCa) is the most frequently diagnosed cancer among females and second cancer after lung cancer in many societies. Ignoring the phenotypes of the BrCa can affect the interpretation of the association between diet and BrCa. The aim of this study was to determine the association between dietary patterns and estrogen receptor (ER), and progesterone receptor (PR) status in women with BrCa. Read More

Nutr Cancer 2019 Apr 22:1-13. Epub 2019 Apr 22.

a Department of Clinical and Experimental Medicine , University of Foggia , Foggia , Italy.

Curcumin is an alkaloid with various pharmacologic properties; numerous investigations have suggested that in the Central Nervous System, Curcumin has anti-inflammatory, antimicrobial, antioxidant, and antitumor effects. Gliomas are the most common primary intracranial tumors in adults. The prognosis of glioblastoma is still dismal. Read More

Nutr Cancer 2019 Apr 16:1-10. Epub 2019 Apr 16.

a Institute of Cell Biophysics of the Russian Academy of Sciences , Pushchino , Moscow Region , Russia.

The topical problem is to find new, more effective and safe treatments for cancer. The purpose of the present work was to study the combined effects of low-intensity extremely high-frequency electromagnetic radiation (EHF EMR) and consumption of n-3 polyunsaturated fatty acids (PUFAs) on tumor growth and the content of FAs in the thymus and tumor tissue in mice. Fatty acid composition was determined using gas chromatography. Read More

Nutr Cancer 2019 Apr 9:1-8. Epub 2019 Apr 9.

c Community Nutrition Department, Faculty of Nutrition Sciences and Food Technology , National Nutrition and Food Technology Research Institute (WHO Collaborating Center), Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Purpose: Various aspects of diet have been implicated to play a role in the etiology of bladder cancer. Studies examining this association have been conducted primarily in Western countries but none in Middle Eastern Countries.

Method: We examined the association between the dietary inflammatory index (DII) and bladder cancer in an Iranian case-control study. Read More

Nutr Cancer 2019 Apr 8:1-8. Epub 2019 Apr 8.

d Department of Medical Biochemistry, Faculty of Medicine , Karadeniz Technical University , Trabzon , Turkiye.

Although several studies have investigated the cytotoxic effects of different Dianthus species, there has been only limited research into the cytotoxic effect of Dianthus carmelitarum. The purpose of this research was to evaluate the phenolic characterization and the cytotoxic effect of D. carmelitarum on human colon cancer (WiDr) cells and the possible mechanisms involved. Read More

Nutr Cancer 2019 Apr 7:1-6. Epub 2019 Apr 7.

c Department of Basic Medical Sciences, Faculty of Nutrition and Food Technology , National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Cellular senescence is generally defined as irreversible cell-cycle arrest and loss of replicative capacity in virtually all cell types which can have effects on tissues and possibly play a significant role in promoting age-related chronic diseases and cancers. Recently, use of natural bioactive substances such as resveratrol to modify the process of cellular senescence in tissue cells based on specific context has opened an interesting therapeutic perspective in aging and chronic diseases such as cancers. This natural polyphenol is currently being evaluated as a promising anticancer and anti-age-related disease agent. Read More

Nutr Cancer 2019 Apr 7:1-11. Epub 2019 Apr 7.

a Department of Epidemiology and Population Health , Albert Einstein College of Medicine , Bronx , New York , USA.

Few studies have explored the associations of thiamin, niacin and riboflavin with risk of cancer despite their role in potentially cancer-associated one-carbon metabolism. Using multivariable Cox proportional hazards regression models modified for the case-cohort design, we examined the associations of dietary intake of the above-mentioned B vitamins, as well as folate, and vitamins B6 and B12, with risk of the breast (n = 922), endometrial (n = 180), ovarian (n = 104) and colorectal (n = 266) cancers among age-stratified subcohorts of 3,185 women who were randomly selected from a cohort of 73,909 participants. None of the B-vitamins were associated with risk of breast or colorectal cancers. Read More

Nutr Cancer 2019 Apr 7:1-12. Epub 2019 Apr 7.

a Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences , Chiang Mai University , Chiang Mai , Thailand.

Leukemic cells remaining in the body is the main problem for cancer patients, and these cells are called Leukemic Stem Cells (LSCs). Many studies have revealed that the overexpression of the Wilms' tumor 1 (WT1) protein is related to leukemogenesis. Curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) from Thai turmeric (Curcuma longa Linn. Read More

Nutr Cancer 2019 Apr 7:1-6. Epub 2019 Apr 7.

k Department of Epidemiology and Biostatistics, School of Public Health , North Khorasan University of Medical Sciences , Bojnurd , Iran.

Aim: Esophageal cancer (EC) is considered one of the most common types of cancer in the world. High intake of dietary proteins is suggested to increase EC. This study examined associations between intake of red meats, processed meat, poultry, and fish and the risk of EC. Read More

Nutr Cancer 2019 Apr 6:1-15. Epub 2019 Apr 6.

a College of Pharmacy , University of Louisiana at Monroe , Monroe , Louisiana , USA.

Cancer cell metabolism is characterized by aerobic glycolysis or the "Warburg effect". Enhanced Akt signaling is associated with activation of various downstream enzymes involved in the glycolytic process, whereas activation of 5'-AMP-activated kinase (AMPK) acts to terminate energy expending mechanisms and decrease glycolytic enzyme expression. Studies were conducted to determine if the anticancer effects of γ-tocotrienol, are mediated through a suppression in aerobic glycolysis. Read More

Nutr Cancer 2019 Apr 7:1-13. Epub 2019 Apr 7.

b Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine , Tabriz University of Medical Sciences , Tabriz , Iran.

In this study, we explored whether co-nanoencapsulated Curcumin (Cur) and Chrysin (Chr), natural herbal compounds with antitumor activities, regulate miR-132 and miR-502c and their downstream targets, leading to the synergistic growth inhibition in MDA-MB-231 breast cancer cells. For this purpose, Cur and Chr were co-encapsulated into PLGA-PEG nanoparticles (NPs) and characterized through DLS, FTIR and FE-SEM. MTT assay and cell cycle arrest analysis revealed that CurChr-loaded NPs had a considerable synergistic cytotoxicity against MDA-MB-231 cells with more cell accumulation in G2/M phase compared to the other groups. Read More

Nutr Cancer 2019 Apr 6:1-10. Epub 2019 Apr 6.

b Department of Pharmacy , Ogaki Municipal Hospital , Ogaki , Gifu , Japan.

Serum albumin has been reported to be a useful indicator of liver function and branched-chain amino acid (BCAA) therapy is associated with a lower incidence of hepatocellular carcinoma (HCC). We investigated the impact of BCAA granule therapy on overall survival and disease-specific survival in patients with normal albumin levels and low BCAA to tyrosine ratio (BTR)s who had treatment-naïve HCC. Overall survival and disease-specific survival was analyzed in 78 patients with HCC who were treated (n = 27) or not treated (n = 51) with BCAAs. Read More

Nutr Cancer 2019 Apr 7:1-8. Epub 2019 Apr 7.

a Department of Internal Medicine, Institute of Gastroenterology , Yonsei University College of Medicine , Seoul , Korea.

Objectives: Although the significance of skeletal muscle mass has been investigated in pancreatic cancer, there are no reports regarding the impact of skeletal muscle mass on prognosis in patients who have undergone second-line chemotherapy. We aimed to identify prognostic factors in patients with advanced pancreatic cancer treated with second-line FOLFIRINOX (folinic acid, fluorouracil, irinotecan, and oxaliplatin).

Methods: We retrospectively reviewed the data of 57 pancreatic cancer patients treated with second-line FOLFIRINOX. Read More

Nutr Cancer 2019 Apr 4:1-8. Epub 2019 Apr 4.

l Discipline of Public Health and Primary Care, Institute of Population Health, Trinity College , University of Dublin , Dublin , Ireland.

25-Hydroxyvitamin D (25-OHD) may have a prognostic value in colorectal cancer (CRC) patients. However, as 25-OHD concentration is strongly impacted by surgery, it is uncertain what is the most reliable time-point for 25-OHD assessment, pre- or post-operative. Therefore, we examined 515 CRC patients (AJCC I-III) who underwent surgery. Read More

Nutr Cancer 2019 Apr 4:1-10. Epub 2019 Apr 4.

a Discipline of Medical Biochemistry and Chemical Pathology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences , University of KwaZulu-Natal , Durban , South Africa.

Aim: Hepatocellular carcinoma is one of the leading global epidemics. A medicinal tree, Moringa oleifera (MO), has been part of traditional treatments including cancer therapies. We investigated the apoptosis inducing effects of MO crude aqueous leaf extract (MOE) in human liver hepatocellular carcinoma (HepG) cells. Read More

Nutr Cancer 2019 Apr 4:1-9. Epub 2019 Apr 4.

a Faculty of Nutrition School of Public Health , Iran University of Medical Sciences , Tehran , Iran.

Gastrointestinal (GI) side effects caused by chemotherapy in women with breast cancer are common but poorly understood which might be controlled by nutritional intervention. Thus, the major aim of this study was to assess the effect of dietary intervention along with nutritional education on reducing these side effects. The present study is a single-center, single-controlled, and randomized trial. Read More

Nutr Cancer 2018 Nov-Dec;70(8):1228-1236. Epub 2019 Mar 22.

a Center for Liver Cancer, National Cancer Center, Goyang-si , Gyeonggi-do , Republic of Korea.

Background: We aimed to assess the nutritional status of cancer patients according to site or treatment type.

Methods: We prospectively evaluated the nutritional status of 1,588 patients based on cancer site and treatment type using the Patient-Generated Subjective Global Assessment tool. We also investigated length of stay (LOS), complication rates after surgery and quality of life (QoL). Read More

Nutr Cancer 2018 Nov-Dec;70(8):1315-1321. Epub 2019 Mar 22.

c College of Medicine , Chang Gung University , Taoyuan City , Taiwan.

Aim: This study aimed to examine the relationship between clinicopathological features, varied malnutrition criteria, and survival in esophageal squamous cell carcinoma (ESCC) patients.

Methods: Six malnutrition criteria (body mass index (BMI) < 18.5 kg/m, serum albumin level < 3. Read More

Nutr Cancer 2019 Mar 15:1-10. Epub 2019 Mar 15.

a Cancer Epidemiology and Intelligence Division , Cancer Council Victoria , Melbourne , VIC, Australia.

Dietary intakes of B vitamins and other components involved in one-carbon metabolism, which is necessary for DNA replication, DNA repair, and regulation of gene expression, may be associated with carcinogenesis. We investigated associations between intakes of 11 nutrients (thiamine, riboflavin, niacin, pantothenic acid, vitamin B6, biotin, folate, vitamin B12, methionine, choline, and betaine) and gastric cancer risk. A total of 159 incident gastric cancer cases were identified from the Melbourne Collaborative Cohort Study (N = 41,513) and matched with 159 controls on year of birth, sex, and country of birth using incidence density sampling. Read More

Nutr Cancer 2019 Mar 15:1-10. Epub 2019 Mar 15.

a Department of Cardiothoracic Surgery , The Third Affiliated Hospital of Soochow University , Changzhou , People's Republic of China.

Numerous studies have demonstrated that serum high-density lipoprotein cholesterol (HDL-C) levels correlate strongly with cancer patient survival. However, other studies have had the opposite results. We therefore conducted a systematic review and meta-analysis to assess the prognostic value of HDL-C levels in people with cancer. Read More

Nutr Cancer 2019 Mar 12:1-8. Epub 2019 Mar 12.

a Discipline of Physiology, Adelaide Medical School , The University of Adelaide , Adelaide , South Australia.

Ulcerative colitis is an unremitting and lifelong inflammatory bowel disease that is increasing in prevalence worldwide. Patients display various clinical symptoms such as abdominal pain, diarrhea and fatigue. The etiology of ulcerative colitis remains unknown and the current pharmaceutical treatments are variably effective and not curative, highlighting the need for improved therapeutic approaches. Read More

Nutr Cancer 2019 Mar 12:1-9. Epub 2019 Mar 12.

a University of Michigan , Ann Arbor , Michigan, USA.

Aim: Soy isoflavones have been suggested as epigenetic modulating agents with effects that could be important in carcinogenesis. Hypomethylation of LINE-1 has been associated with head and neck squamous cell carcinoma (HNSCC) development from oral premalignant lesions and with poor prognosis. To determine if neoadjuvant soy isoflavone supplementation could modulate LINE-1 methylation in HNSCC, we undertook a clinical trial. Read More

Nutr Cancer 2019 Mar 12:1-13. Epub 2019 Mar 12.

h h Botany Department, Faculty of Science , Menofiya University , Egypt.

The modulatory role of the Bifidobacterium longum (BL), isolated from women breast milk, on some oncogenic and tumor suppressor miRNAs as well as IL-1β and IL6 targeted-miRNAs was investigated using murine colorectal cancer (CRC) induced on the top of inflammatory ulcerative colitis model. The investigation of the oncomiRs miR-21a and miR-155, which regulate IL-6 and IL-1β expression, indicated that both was depressed by BL-administration in healthy and in CRC-mice. BL-administration induced the tumor suppressor miRNAs (miR-145 and miR-15a) expression in both of the healthy and in CRC-mice. Read More

Nutr Cancer 2019 Mar 11:1-16. Epub 2019 Mar 11.

a Cancer Research Institute, Advanced Centre for Treatment , Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC) , Kharghar , Navi Mumbai , India.

Our understanding of dose-related effects of polymeric black tea polyphenols (PBPs), the most abundant polyphenols in black tea, is limited. In the present study, the effect of various doses of black tea (0.75, 1. Read More

Nutr Cancer 2019 Mar 8:1-6. Epub 2019 Mar 8.

b Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery , Nippon Medical School , Tokyo , Japan.

Introduction: Cisplatin (CDDP) induces loss of muscle mass by activating the nuclear factor (NF)-κB signaling pathway. In this study, we investigated the effects of eicosapentaenoic acid (EPA), which inhibits NF-κB activation, on CDDP-induced loss of muscle mass in mice.

Methods: Male C57BL/6J mice received a single dose of CDDP and olive oil, linseed oil, or EPA daily for 4 days. Read More

Nutr Cancer 2019 Mar 8:1-10. Epub 2019 Mar 8.

a Department of Community Nutrition, School of Nutritional Sciences and Dietetics , Tehran University of Medical Sciences , Tehran , Iran.

No study has summarized earlier findings on the association of sweetened beverages (SBs) consumption and risk of Pancreatic Cancer (PC). This systematic review and meta-analysis was conducted to systematically review available observational studies that examined the association of SB consumption with risk of PC. Relevant papers published up to December 2017 were searched through PubMed, MEDLINE, SCOPUS, EMBASE, and Google Scholar databases, using relevant keywords. Read More

Nutr Cancer 2019 Mar 7:1-9. Epub 2019 Mar 7.

e Department of Gastroenterology , the Affiliated Hospital of North Sichuan Medical College , Sichuan , China.

Aim: Few evidences are available regarding the link between microbiota composition in the human colorectal cancer (CRC) tissues and the patients' clinicopathological features.

Methods: Microbiota diversity in CRC tissues (n = 30) were profiled and compared by high-throughput sequencing with clinicopathological features, including tumor location, differentiation degree, metastasis, and CRC patients' gender and age.

Results: Many bacteria with significant difference in abundance were identified associated with these clinicopathological features (P < 0. Read More

Nutr Cancer 2019 Mar 5:1-10. Epub 2019 Mar 5.

c Institute of Nutrition, Mahidol University , Nakhon Pathom , Thailand.

Weight loss is common in cancer patients underwent radiation therapy. However, the impact of pretreatment behavior on postradiation nutritional status was unknown. This prospective observational study was conducted in 31 Thai head and neck cancer patients to investigate the association between pretreatment dietary preference and weight change after radiotherapy. Read More

Nutr Cancer 2019 Mar 5:1-8. Epub 2019 Mar 5.

a Department of Obstetrics & Gynecology , Hamamatsu University School of Medicine , Shizuoka , Japan.

Short-chain fatty acids (SCFAs) produced by fermentation from prebiotics not only provide energy but also activate cell membrane receptors, thereby contributing to the maintenance of homeostasis in the human body. Recently, free fatty acid receptor 2 (FFAR2), which uses SCFAs as ligands, was found to exert oncoprotective effects on several types of neoplasia. This study examined whether SCFAs have oncoprotective effects on uterine cervical neoplasia. Read More

Nutr Cancer 2019 Feb 22:1-7. Epub 2019 Feb 22.

e Clinical Oncology Department, Faculty of Medicine , Mansoura University , Mansoura , Egypt.

Overweight and obesity in the pediatric population remains a growing worldwide health burden. The extent to which this trend extends to childhood cancer survivors (CCS) remains less well explored. We conducted a retrospective observational study from a single institution in Saudi Arabia to estimate the prevalence of overweight and obese status among CCS over a five-year period. Read More

Nutr Cancer 2019 Feb 22:1-12. Epub 2019 Feb 22.

a Department of General Surgery , The Third Hospital of Mianyang the Mental Health Center of Sichuan , Mianyang , Sichuan , China.

Objective: The primary aim of this systematic review was to evaluate the survival predication value of preoperative prognostic nutritional index (PNI) in patients with gastric cancer. The second aim was to explore the relationship between preoperative PNI and clinicopathological features.

Methods: A systematic search of the electronic databases identified studies that investigated the association of preoperative PNI with short or long-term outcomes among patients after gastrectomy for cancer. Read More

Nutr Cancer 2019 Feb 20:1-11. Epub 2019 Feb 20.

a Cancer and Translational Research Lab, Dr D. Y. Patil Biotechnology & Bioinformatics Institute, Dr D.Y. Patil Vidyapeeth , Pune , India.

Insights in RNA biology have opened up a plethora of opportunities to explore the small regulatory RNAs from various natural and artificial sources. These small RNAs have been suggested to play a role too in tumor progression by either as oncogenic or tumor suppressor small RNAs. In this study, authors have attempted to evaluate the therapeutic potential of small RNAs fractionated from corn (Zea mays) upon growth and survival of HeLa. Read More

Nutr Cancer 2019 18;71(1):61-76. Epub 2019 Feb 18.

e Department of Medicine , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.

Purpose: Little is known about the dietary behaviors of African-American breast cancer survivors (AABCS). We sought to describe dietary intake and quality in AABCS and examine associations with demographic, social, lifestyle, and body composition factors to potentially inform the development of effective dietary interventions.

Methods: Baseline data from a prospective weight loss trial of 210 AABCS were assessed. Read More

Nutr Cancer 2019 9;71(1):118-127. Epub 2019 Feb 9.

a Department of Marine-Bio Convergence Science , Pukyong National University , Busan , Republic of Korea.

Recent evidence provides that seafood has a lot of health benefits due to its unique bioactive compounds. Sea squirt is widely cultured and consumed as a foodstuff in Korea; however, seldom reports with reference to bioactivities are available until now. In this study, edible part of sea squirt was hydrolyzed by pepsin and its hydrolysates was evaluated for anticancer effect on human colon cancer HT-29 cells. Read More

Nutr Cancer 2019 Feb 9:1-20. Epub 2019 Feb 9.

c Discipline of Surgery, School of Medicine , University of Sydney , Camperdown , NSW , Australia.

Despite improvements in safety of hepatic resection post-operative complications occur in up to a half of patients. A systematic review was undertaken to compare the effect of pre-operative and peri-operative nutritional supplementation on post-operative outcomes in patients undergoing hepatic resection for malignancy. Included studies were identified through a search of PubMed (1966 to November 2016), Embase (1947 to November 2016) and the Cochrane Library (1993 to November 2016). Read More

Nutr Cancer 2019 9;71(1):111-117. Epub 2019 Feb 9.

d Departamento de Patologia Médica , Hospital das Clínicas, Universidade Federal do Paraná , Curitiba , Brazil.

Capsaicin (trans-8-methyl-n-vanillyl-6-nonenamide) is the main pungent component found in hot peppers.

Aim: In this study, we investigated the effect of capsaicin treatment on tumor growth and the metabolic indicators of cachexia in Walker 256 tumor-bearing rats.

Methods: Male Wistar rats were inoculated subcutaneously in the right flank with 1 ml of a sterile suspension of 3 × 10 Walker tumor cells. Read More

Nutr Cancer 2018 Nov-Dec;70(8):1184-1198. Epub 2019 Feb 9.

a Computational Modeling and Nano Scale Processing Unit , Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Government of India , Thanjavur , Tamil Nadu, India.

At present, cancer is one of the major diseases in the world affecting numerous lives. There have been various approaches to combat the disease, particularly involving chemical interventions (chemotherapy). However, owing to serious side effects of chemotherapy, employment of natural supplements in cancer therapy has been long desired. Read More

Nutr Cancer 2019 9;71(1):50-60. Epub 2019 Feb 9.

k Department of Gastrointestinal Surgery/Clinical Nutrition , Beijing Shijitan Hospital, Capital Medical University , Beijing , PR China.

Malnutrition is a problem affecting tumor patients greatly. This study aims to investigate whether demographic characteristics are related to the malnutrition of cancer patients. Twenty-three thousand nine hundred and four (23,904) patients with 16 common malignant tumors were enrolled in the study. Read More

Nutr Cancer 2019 Feb 9:1-5. Epub 2019 Feb 9.

f School of Clinical Sciences , Monash University , Clayton , Victoria , Australia.

Combination gemcitabine and nab-paclitaxel (Gem-Nab-P) is a common regimen used to treat metastatic pancreatic ductal adenocarcinoma (PDAC). Toxicity from this regimen is associated with significant morbidity. Currently, Gem-Nab-P is dosed using estimated body surface area, derived from height and weight. Read More

Nutr Cancer 2019 26;71(1):21-40. Epub 2019 Jan 26.

a Department of Surgery , University of Rochester Medical Center (URMC) , Rochester , New York , USA.

Cancer-related fatigue (CRF) is a debilitating syndrome that persists for many cancer survivors for years after treatment. Symptoms include early and persistent fatigue, functional decline, depression, and cognitive difficulties. Inflammation, assessed using pro-inflammatory biomarkers, is increased in cancer survivors with fatigue and treatments for fatigue are often aimed at reducing inflammation. Read More

Nutr Cancer 2019 26;71(1):83-88. Epub 2019 Jan 26.

g Palliative and Supportive Care Division , Seirei Mikatahara Hospital , Hamamatsu , Japan.

Objectives: Phase angle (PA) is a poor prognostic factor in patients with advanced cancer. This study aimed to identify possible correlations between PA and symptoms, quality of life, fluid retention, and laboratory data in cancer patients in palliative care settings.

Methods: Individuals who visited the outpatient clinic or were admitted to the palliative care unit were eligible. Read More

Nutr Cancer 2019 26;71(1):1-12. Epub 2019 Jan 26.

d Department of Traditional Pharmacy, School of Persian Medicine , Tehran University of Medical Sciences , Tehran , Iran.

Breast cancer is the most common cancer among women. Need for novel preventive and curative approaches with more safety than the present one seems inevitable. This review is devoted to potentially favorable role of probiotics in prevention and treatment of breast cancer as well as their alleviating role regarding chemotherapy-induced side effects. Read More

Nutr Cancer 2019 Jan 26:1-5. Epub 2019 Jan 26.

a Division of Thoracic Oncology , Shizuoka Cancer Center , Shizuoka , Japan.

This study aimed to explore the tolerability and safety of platinum combination chemotherapy in malnourished patients with advanced non-small cell lung cancer (NSCLC) and poor performance status (PS). We retrospectively reviewed NSCLC patients with a PS of 2 who received first-line platinum combination chemotherapy at the Shizuoka Cancer Center between December 2009 and December 2014. Nutritional status was classified using the Glasgow Prognostic Score (GPS), which is an indicator of systemic inflammation and malnutrition. Read More

Nutr Cancer 2018 Nov-Dec;70(8):1254-1263. Epub 2019 Jan 26.

a Department of Surgical Oncology , First Affiliated Hospital of China Medical University , Heping District , Shenyang , People's Republic of China.

Objective: In this study, we performed a systematic review and meta-analysis to evaluate the impact of preoperative underweight status on postoperative complications and survival outcome of gastric cancer (GC) patients.

Methods: The related studies were identified by searching PubMed and Embase databases. According to the body mass index (BMI), all patients were classified into underweight group (<18. Read More

Nutr Cancer 2019 Jan 26:1-11. Epub 2019 Jan 26.

a Food Engineering and Technology Department , Institute of Chemical Technology , Mumbai , India.

Sample urban population was assessed for consumption of legumes. Genistein and daidzein content of commonly consumed legumes was evaluated to estimate the isoflavone intake through the consumption of these legumes by selected population. Total genistein content of all legumes considered for analysis was found to be in the range of 0. Read More

Nutr Cancer 2019 Jan 24:1-14. Epub 2019 Jan 24.

a Department of Biochemistry and Molecular Biology , Centre of Postgraduate Medical Education , Warsaw , Poland.

Multidrug resistance is one of the key barriers suppressing the effectiveness of drug therapies of malignant tumors. Here, we report a study on the effect of a mix of natural extracts (MIX2) prepared from fresh fruits of Prunus spinosa, Crataegus monogyna, Sorbus aucuparia, and Euonymus europaeus on the classic hallmarks of cancer cells and the expression of multidrug resistance proteins. In the studies, HeLa and T98G cell lines, and classic methods of molecular biology, including RT-qPCR, Western blot, flow cytometry, and confocal imaging, were used. Read More

Nutr Cancer 2019 Jan 23:1-9. Epub 2019 Jan 23.

b Department of Orthopedics , The First Hospital of Hebei Medical University , Shijiazhuang , PR China.

Objective: To investigate the protective effects and underlying mechanisms of Vitamin C (VC) on hydrocortisone (HC)-induced cell injury in human microvascular endothelial cells (HMEC).

Methods: Cell viability was measured by CCK-8 assay and the expression of Best-3 was detected by Western blotting assay. The experiment was divided into normal control, HC injury group, VC treatment groups, HC + Best-3 siRNA group, HC + VC + Best-3 siRNA group, HC + pcDNA3. Read More