438,946 results match your criteria Nutrition Metabolism & Cardiovascular Diseases [Journal]
J Food Sci 2018 Dec 17. Epub 2018 Dec 17.
the Konkuk Univ., Hwayang-dong, Gwangjin-gu, Seoul, The Republic of Korea.
The presence of unwanted competing flora has been the most common confounding factor in the enumeration of Bacillus cereus (B. cereus) using selective media such as mannitol-yolk-polymyxin B agar (MYPA). The objective of this study was to improve MYPA selectivity for B. Read More
J Food Sci 2018 Dec 17. Epub 2018 Dec 17.
Dept. of Microbiology and Molecular Biology, Chungnam Natl. Univ., 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Republic of Korea.
In this study, the phenolic components, as well as the antioxidant and antimicrobial activities, of the ripe and unripe fruit of pawpaw (Asimina triloba [L.] Dunal) extracted using five different solvents (distilled water, 95% methanol, 80% methanol, 95% ethanol, and 80% ethanol) were analyzed. The total phenolic content and total flavonoid content were the highest in the 95% ethanol (149. Read More
Physiol Meas 2018 Dec 17. Epub 2018 Dec 17.
Research Center in Kinanthropometry and Human Performance, Federal University of Santa Catarina, Florianopolis, BRAZIL.
The objective was to compare indicators of fluid distribution and cellular integrity in university athletes. Cross-sectional study with 167 university athletes (18-35 years), of team and individual sports. The bioimpedance was used to measure body water (TBW), intracellular water (ICW), extracellular water (ECW), ECW/ICW, impedance (Z), reactance (Xc), resistance (R), phase angle, body cell mass (BCM) and ECW/BCM at frequency 50khz. Read More
Water Res 2018 Dec 6;150:418-430. Epub 2018 Dec 6.
College of Environmental & Resource Sciences, Zhejiang University, Hangzhou, 310058, China; Ministry of Education Key Laboratory of Environment Remediation and Ecological Health, Zhejiang University, Hangzhou, 310058, China. Electronic address:
Accurate source identification is critical for optimizing water pollution control strategies. Although the dual stable isotope (N-NO/O-NO) approach has been widely applied for differentiating riverine nitrogen (N) sources, the relatively short-term (<1 yr) N-NO/O-NO records typically used in previous studies often hinders rigorous assessment due to high temporal variability associated with watershed N dynamics. Estimated contributions of legacy N sources in soils and groundwater to riverine N export by modeling approaches in many previous studies also lack validation from complementary information, such as multiple stable isotopes. Read More
Environ Int 2018 Dec 14;123:325-336. Epub 2018 Dec 14.
State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:
Background: The evaluation of the chemical impact on human health is usually constrained to the analysis of the health effects of exposure to a single chemical or a group of similar chemicals at one time. The effects of chemical mixtures are seldom analyzed. In this study, we applied three statistical models to assess the association between the exposure to a mixture of seven xenobiotics (three phthalate metabolites, two phenols, and two pesticides) and obesity. Read More
Environ Int 2018 Dec 14;123:310-317. Epub 2018 Dec 14.
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:
Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM (≤1. Read More
Soc Sci Med 2018 Dec 10;221:58-67. Epub 2018 Dec 10.
The University of Texas at San Antonio, United States.
Rationale: Food insecurity is a significant public health concern, with implications for community and individual health and well-being. Although a growing body of literature points to the role of neighborhoods in household food insecurity, studies using nationally representative samples to explore interactions between neighborhood risks - including violence and danger - are lacking.
Objective: The present study examines whether interactions between physical disorder, low social capital, and violence/danger in the neighborhood have significant implications for the risk of household food insufficiency using a large, nationally representative sample of U. Read More
Nutrition 2018 Oct 22;60:122-128. Epub 2018 Oct 22.
University Hospital Muenster, Department of Pediatrics, Muenster, Germany.
Objectives: Multiple acyl-CoA dehydrogenase deficiency (MADD) is the most severe disorder of mitochondrial fatty acid β-oxidation. Treatment of this disorder is difficult because the functional loss of the electron transfer flavoprotein makes energy supply from fatty acids impossible. Acetyl-CoA, provided by exogenous ketone bodies such as NaßHB, is the only treatment option in severe cases. Read More
Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Division of Gastroenterology, Hepatology and Nutrition, Section of Interventional and Advanced Endoscopy, Department of Medicine, University of Minnesota, MMC 36, 420 Delaware St SE, Minneapolis, MN 55455. Electronic address:
Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Ambry Genetics, Aliso Viejo, CA.
Background And Aims: Guidelines recommend genetic testing of patients with 10 or more cumulative adenomatous polyps. However, little is known about the utility of these tests-especially for older patients. We aimed to determine the prevalence of pathogenic mutations in patients with multiple colorectal polyps, stratified by age. Read More
Cell Mol Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Cardiovascular Research Center and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510-3221, USA; INSERM U970, Paris Cardiovascular Research Center, 75015 Paris, France.
The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid. Historically, despite its crucial functions in intestinal homeostasis, the lymphatic system has been poorly studied. In the last two decades, identification of specific molecular mediators of lymphatic endothelial cells (LECs) growth together with novel genetic approaches and intravital imaging techniques, have advanced our understanding of the mechanisms regulating intestinal lymphatic physiology in health and disease. Read More
Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.
University of Reading, Department of Food and Nutritional Sciences, PO Box 226, Whiteknights, Reading, RG6 6AP, UK.
Low/no-calorie sweeteners (LNCS) are continually under the spotlight in terms of their safety and benefits; in 2014 a study was published linking LNCS to an enhanced risk of glucose intolerance through modulation of the gut microbiota. In response, an in-depth review of the literature was undertaken to evaluate the major contributors to potential changes in the gut microbiota and their corresponding sequelae, and to determine if consuming LNCS (e.g. Read More
Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.
Food Colloids Group, Department of Food Technology, Engineering and Nutrition, Faculty of Engineering LTH, Lund University, PO Box 124, S-221 00 Lund, Sweden. Electronic address:
Three Andean grains - amaranth (Amaranthus caudatus), quinoa (Chenopodium quinoa), canihua (Chenopodium pallidicaulle) - and two Andean roots starches - achira (Canna indica), maca (Lepidium meyenii) - were studied. Physicochemical properties such as granule size, crystallinity, pasting properties among other as well as structural properties such as root-mean-square radius (r), weight-average molar mass (M) and apparent density (ρ) were analyzed in order to evaluate the relation between them. Grains were similar in most of their characteristics as roots in their i. Read More
Bone 2018 Dec 14. Epub 2018 Dec 14.
Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA; Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USA.
Background: Body mass compartments may have different directions of influence on bone accrual. Studies of children are limited by relatively small sample sizes and typically make strong assumptions of linear regression.
Objective: To evaluate associations of overall body mass, components of overall body mass (fat-free and total fat), and components of total fat mass (truncal and non-truncal fat), measured via dual-energy X-ray absorptiometry (DXA) and anthropometry, with total body less head areal bone mineral density (aBMD) Z-score in mid-childhood. Read More
Physiol Behav 2018 Dec 14. Epub 2018 Dec 14.
Division of Behavioral Sciences & Community Health, University of Connecticut School of Dental Medicine, Farmington, CT, United States.
Chronic cigarette smoking may influence chemosensory function, which in turn, may affect cigarette usage. Because menthol in cigarettes can attenuate nicotine bitterness, choice of menthol/nonmenthol cigarettes may be influenced by ability to perceive bitterness. We examined chemosensory function of chronic smokers, hypothesizing they would show altered function in comparison to non-smokers and by menthol cigarette preference. Read More
Cochrane Database Syst Rev 2018 Dec 17;12:CD008901. Epub 2018 Dec 17.
Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 630 West 168th St., New York, NY, USA, 10032.
Background: Cystic fibrosis (CF) is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with CF often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant human growth hormone (rhGH), has been proposed as a potential intervention. Read More
Physiol Rep 2018 Dec;6(24):e13926
Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.
The antioxidant Selenoprotein S (Seps1, Selenos) is an endoplasmic reticulum (ER)-resident protein associated with metabolic and inflammatory disease. While Seps1 is highly expressed in skeletal muscle, its mechanistic role as an antioxidant in skeletal muscle cells is not well characterized. In C2C12 myotubes treated with palmitate for 24 h, endogenous Seps1 protein expression was upregulated twofold. Read More
PLoS One 2018 17;13(12):e0208711. Epub 2018 Dec 17.
Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Aims: It has been suggested that empirically developed dietary inflammatory potential (EDIP) is a diagnostic tool for assessment of inflammatory potential of diet in prediction of risk factors related to chronic disease. In the current work, we examined the association between EDIP with cardio-metabolic risk factors, dietary antioxidant quality score (DAQs), dietary phytochemical index (DPI) and Mediterranean dietary quality index (MEDQI) in patients candidate for CABG.
Materials And Methods: In the current cross-sectional study, the data obtained from Tehran- Heart Center-Coronary Outcome Measurement (THC-COM) study from 454 patients candidate for the CABG were used. Read More
PLoS One 2018 17;13(12):e0208887. Epub 2018 Dec 17.
Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, P. R. China.
Deep-sea hydrothermal vents in the western Pacific are increasingly explored for potential mineral extraction. The study of the composition of the food web plays an important guiding role in the ecological protection and restoration of potential mining areas. The general picture of the nutritional sources of species should be established to assess the potential impacts of future mining activities on the biological composition and food sources. Read More
PLoS Negl Trop Dis 2018 Dec 17;12(12):e0007045. Epub 2018 Dec 17.
Department of Nutrition, University of California, Davis, California, United States of America.
Background: Myriad infectious and noninfectious causes of encephalomyelitis (EM) have similar clinical manifestations, presenting serious challenges to diagnosis and treatment. Metabolomics of cerebrospinal fluid (CSF) was explored as a method of differentiating among neurological diseases causing EM using a single CSF sample.
Methodology/principal Findings: 1H NMR metabolomics was applied to CSF samples from 27 patients with a laboratory-confirmed disease, including Lyme disease or West Nile Virus meningoencephalitis, multiple sclerosis, rabies, or Histoplasma meningitis, and 25 controls. Read More
PLoS One 2018 17;13(12):e0208974. Epub 2018 Dec 17.
Division of Pediatric Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.
Background: Accurate classification of patients with inflammatory bowel disease into the subtypes ulcerative colitis (UC) and Crohn's disease (CD) is still a challenge, but important for therapy and prognosis.
Objectives: To evaluate the diagnostic utility of anti-neutrophil cytoplasmic antibodies specific for proteinase-3 (PR3-ANCA) for ulcerative colitis (UC) and the value of an antibody panel incorporating PR3-ANCA to differentiate between Crohn's disease (CD) and UC.
Study Design: In this cohort study, 122 pediatric and adolescent individuals were retrospectively included (61 IBD patients of two clinical centers, 61 non-IBD controls). Read More
Crit Care Med 2019 Jan;47(1):e64
Department of Respiratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, P.R. China; Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China; Department of Cardiology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Eur J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Institute of Nutrition and Food Technology Fernando Monckeberg Barros, University of Chile.
Several investigations have found that industry-funded studies tend to inform results favoring the sponsored products. The pressure to demonstrate that a drug or a product causes a favorable outcome may result in investigation biases from industry-funded research. One example of this could be found in the probiotic research funded by the industry. Read More
J Hypertens 2018 Dec 13. Epub 2018 Dec 13.
Department of Epidemiology.
Objective: Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from childhood to early adulthood and adult hypertension in the Chinese population. Read More
J Strength Cond Res 2018 Dec 14. Epub 2018 Dec 14.
State University of Maringa, Parana, Brazil.
Magnani Branco, BH, Carvalho, IZ, Garcia de Oliveira, H, Fanhani, AP, Machado dos Santos, MC, Pestillo de Oliveira, L, Macente, SB, and Nelson, NJ. Effects of 2 types of resistance training models on obese adolescents' body composition, cardiometabolic risk, and physical fitness. J Strength Cond Res XX(X): 000-000, 2018-The main objective of this study was to investigate the effects of 2 types of resistance training (RT) models in conjunction with interdisciplinary interventions by other health professionals to reduce the body fat and cardiometabolic risk of obese adolescents while improving their general health-related physical fitness. Read More
Xenobiotica 2018 Dec 17:1-22. Epub 2018 Dec 17.
a Department of Surgery and Cancer, Faculty of Medicine , Imperial College London, South Kensington Campus , London , SW7 2AZ, United Kingdom.
1. The metabolic fate and urinary excretion of 2-bromophenol, a phenolic metabolite of bromobenzene, was investigated in male Sprague Dawley rats following single intraperitoneal doses at either 0, 100 or 200 mg/kg. 2. Read More
J Spinal Cord Med 2018 Dec 17:1-9. Epub 2018 Dec 17.
c Department of Physical Medicine and Rehabilitation , University of Michigan , Ann Arbor , Michigan , USA.
Objective/background: To examine how demographic and injury characteristics identify satisfaction with life (SWL), and assess the differential effects of a wellness intervention by baseline SWL groups.
Design: Baseline and longitudinal analysis of a randomized controlled pilot intervention using decision tree regression and linear mixed models.
Setting: Community based. Read More
Diab Vasc Dis Res 2018 Dec 17:1479164118816221. Epub 2018 Dec 17.
1 Hypertension in Africa Research Team (HART) and School for Physiology, Nutrition and Consumer Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Objective:: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort.
Methods:: Black and White teachers (N = 338, aged 20-63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Read More
Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8537-8551
Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Objective: Several nutritional strategies for the management of psoriasis are promising. Even if recent data support that nutrition may play a pivotal role in prevention and co-treatment and despite patient's concerns regarding the best nutritional habits, the consensus regarding the nutritional strategies to be adopted lacks in clinical settings. In this manuscript, the effects of several nutritional strategies for psoriasis patients such as hypocaloric diet, vitamin D, fish oil, selenium, and zinc supplementation were systematically reviewed. Read More
Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8472-8479
Department of Endocrinology and Nutrition, Endocrinology and Nutrition Research Center, School of Medicine, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Objective: A common G-to-A transition (rs670) of the Apoprotein subtype 1 APOA1 gene has been evaluated. The presence of the A allele has been related with increased activity. We investigated the role of this genetic variant (rs670) on lipoprotein levels and anthropometric parameters after biliopancreatic diversion (BPD) surgery in morbid obese patients. Read More
Am J Physiol Heart Circ Physiol 2019 Jan 9;316(1):H106-H112. Epub 2018 Nov 9.
Department of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
Continuous laminar shear stress increases the process of autophagy, activates endothelial nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOS), and generates NO in bovine and human arterial endothelial cells (ECs) compared with static controls. However, the translational relevance of these findings has not been explored. In the current study, primary ECs were collected from the radial artery of 7 men using sterile J-wires before (Pre) and after (Post) 60 min of rhythmic handgrip exercise (HG) performed with the same arm. Read More
Recent Pat Food Nutr Agric 2018 Dec 17. Epub 2018 Dec 17.
Department of Biochemistry, University of Port Harcourt, Choba, Rivers State. Nigeria.
Objectives: Plantain pseudostem (PPS) wastes were biotransformed by applying simultaneous saccharification and fermentation (SSF) using excised snail digestive juice and yeast slurry, and their oil properties compared with oils from commercially sold poultry feeds (PF). Patents suggesting inclusion of certain additives (US20090226558A1), spices (US5741508A), cysteamine (US4711897A), and dextrin (US6326051B1) in animal diets are regarded as expensive, thus, requiring cheaper and readily available sources of growth.
Methods: The analysis of their free radical scavenging potentials was carried by spectrophotometry, while fatty acids, volatile fatty acids, essentials oils, and phytosterols were determined by chromatography. Read More
Curr Pharm Biotechnol 2018 Dec 17. Epub 2018 Dec 17.
Department Of Chemistry, Faculty of Food Sciences, Warsaw University of Life Sciences. Poland.
Phenolic acids are secondary plant metabolites belonging to polyphenol classes, widely spread throughout the plant kingdom. The name "phenolic acids", in general, describes phenols that possess one carboxylic acid functionality and they could be divided into three major subclasses: hydroxybenzoic, hydroxycinnamic and hydroxyphenylacetic acids. The great interest in phenolic acids is associated with their high potential for food preservation (antioxidant and antimicrobial activity) and, last but not least, high therapeutic potential. Read More
Biosci Biotechnol Biochem 2018 Dec 16:1-5. Epub 2018 Dec 16.
b Department of Life Environment , Koshien Junior College , Nishinomiya , Japan.
The present review deal with the novel studies which present possibility of generating a novel sensory evaluation instrument for describing comprehensive food palatability. These studies suggest the palatability can be dissected into its componential subdomains and the subdomains in turn reconstitute comprehensive palatability with evaluation of the quantitative contribution of each subdomain. The studies suggest the novel instrument is useful for comprehensive evaluation of palatability of multifarious fermented foods. Read More
Orv Hetil 2018 Dec;159(51):2183-2192
Magatartástudományi Intézet, Általános Orvostudományi Kar Szeged, Szentháromság u. 5., 6722.
Introduction: Nutrition is one of the key factors in health maintainance. So developing appropriate eating habits is very important in adolescence. Dietary behaviour may be influenced by certain aspects of personality, e. Read More
Geriatr Gerontol Int 2018 Dec 16. Epub 2018 Dec 16.
Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.
Aim: Centenarians represent a biological model of successful aging because they escaped/postponed most invalidating age-related diseases, such as cardiovascular diseases. The aim of the present study was to clarify whether a favorable cardiovascular risk profile increases the survival chances in long-lived people.
Methods: A total of 355 community-dwelling nonagenarians and centenarians living in Southern Italy were recruited in the study. Read More
Matern Child Nutr 2018 Dec 16:e12769. Epub 2018 Dec 16.
Population Research Centre, Faculty of Spatial Sciences, University of Groningen, The Netherlands.
Stunting affects large numbers of under-fives in Tanzania. But do caretakers of under-fives recognize height as a marker of child growth? What meanings do they attach to linear growth? An ethnographic study using cultural schemas theory was conducted in a rural community in Southeastern Tanzania to investigate caregivers' conceptualizations of child height in relation to growth and the meanings attached to short stature. Data for the study was collected through 19 focus group discussions, 30 in-depth interviews, and five key informant interviews with caregivers of under-fives, including mothers, fathers, elderly women, and community health workers. Read More
J Peripher Nerv Syst 2018 Dec 16. Epub 2018 Dec 16.
Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova.
The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune-mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, peripheral nerves) and on the involved structures (myelin, axon, cell body). Read More
Pediatr Diabetes 2018 Dec 17. Epub 2018 Dec 17.
Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Background: The diagnosis of type 1 diabetes (T1D) in youth is often associated with diabetic ketoacidosis (DKA). We aimed to evaluate if the presence of DKA at diagnosis of T1D is associated with less favorable hemoglobin A (HbA1c) trajectories over time.
Methods: The SEARCH for Diabetes in Youth study of 1396 youth aged <20 years with newly diagnosed T1D were followed for up to 13 [median 8 (IQR 6-9)] years post-diagnosis. Read More
Hum Brain Mapp 2018 Dec 16. Epub 2018 Dec 16.
Decision Neuroscience Laboratory, University of Illinois, Urbana, Illinois.
A wealth of neuroscience evidence demonstrates that diet and nutrition play an important role in structural brain plasticity, promoting the development of gray matter volume and maintenance of white matter integrity across the lifespan. However, the role of nutrition in shaping individual differences in the functional brain connectome remains to be well established. We therefore investigated whether nutrient biomarkers known to have beneficial effects on brain structure (i. Read More
Anim Sci J 2018 Dec 16. Epub 2018 Dec 16.
Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an, China.
Two experiments were conducted to determine the standardized ileal digestible lysine (SID Lys) requirement for weaned pigs fed with low crude protein (CP) diet. In Experiment 1, 144 pigs were fed a normal CP (20%) diet with 12.3 g/kg SID Lys and five low CP (18. Read More
J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Diabetic retinopathy (DR) is one of the major complications of diabetes mellitus that causes diabetic macular edema and visual loss. DR is categorized, based on the presence of vascular lesions and neovascularization, into non-proliferative and proliferative DR. Vascular changes in DR correlate with the cellular damage and pathological changes in the capillaries of blood-retinal barrier. Read More
Environ Toxicol Chem 2018 Dec 17. Epub 2018 Dec 17.
Study Group on Wild Animal Conservation Medicine (GEMAS).
Lead poisoning is a significant threat faced by raptors. Hence, rapid lead diagnosis has become a priority during the admission of raptors in Wildlife Recovery Centers (WRCs), and bench-top analyzers - such as LeadCare II - are routinely employed for this purpose. However, this device has been designed for conducting the analysis of human blood lead levels (BLL), and the validity of this methodology for whole blood from raptors has, to date, rarely been assessed. Read More
J Labelled Comp Radiopharm 2018 Dec 16. Epub 2018 Dec 16.
Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Hyogo, Japan.
To enable positron emission tomography (PET) imaging of the in-vivo kinetics of ubiquinone and ubiquinol, which is referred to as coenzyme Q , their C-radiolabeled counterparts were synthesized herein. C-Labeled ubiquinone [ C]-1 was realized by Pd-mediated rapid C-[ C] methylation of [ C]CH I with 39-demethyl-39-(pinacolboryl) ubiquinone, prepared by Ru-catalyzed olefin metathesis of unradiolabeled ubiquinone with 2-(pinacolboryl)propene. Subsequent reduction of [ C]-1 using Na S O yielded C-labeled ubiquinol [ C]-2. Read More
Clin Exp Immunol 2018 Dec 17. Epub 2018 Dec 17.
Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital Sheba Medical Center.
Background: The antigenic specificity of T cells occurs via generation and rearrangement of different gene segments producing a functional T cell receptor (TCR). High throughput sequencing (HTS) allows in-depth assessment of TCR repertoire patterns. There is limited data whether TCR repertoires are altered in inflammatory bowel disease. Read More
Hepatol Commun 2018 Dec 10;2(12):1533-1549. Epub 2018 Oct 10.
Sorbonne Université, INSERM Centre de Recherche Saint-Antoine (CRSA), and Institute of Cardiometabolism and Nutrition (ICAN) Paris France.
The most typical expression of cystic fibrosis (CF)-related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the potential impact of environmental and genetic factors on the development of CF-related cholangiopathy in mice. Cystic fibrosis transmembrane conductance regulator () mice and littermates in a congenic C57BL/6J background were fed a high medium-chain triglyceride (MCT) diet. Read More
Hepatol Commun 2018 Dec 13;2(12):1440-1445. Epub 2018 Nov 13.
Department of Gastroenterology/Hepatology/Nutrition Cleveland Clinic Cleveland OH.
The prevalence polyps (GBPs) in the general population has been estimated to be approximately 5%, with up to 10% of these being dysplastic or malignant. Previous studies have suggested that patients with primary sclerosing cholangitis (PSC) have increased frequency of GBPs. However, data on the prevalence, risk factors, and outcome of GBPs in these patients are sparse. Read More
ACS Omega 2018 Nov 27;3(11):15988-15995. Epub 2018 Nov 27.
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences and Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Hempseed has achieved a growing popularity in human nutrition, particularly regarding essential amino acids and fatty acids. The multiple positive attributes of hempseed have led to the further study of its constituents. In this study, hempseed extract containing phenylpropionamides (TPA) was obtained and its chemical profile and content were obtained using high-performance liquid chromatography technology based on previous study. Read More
ACS Omega 2018 Nov 27;3(11):15952-15965. Epub 2018 Nov 27.
ISOF, Consiglio Nazionale delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, Italy.
The use of copper complexes for redox and oxidative-based mechanisms in therapeutic strategies is an important field of multidisciplinary research. Here, a novel Cu(II) complex [Cu(TPMA)(Phen)](ClO) (Cu-TPMA-Phen, where TPMA = tris-(2-pyridylmethyl)amine and Phen = 1,10-phenanthroline) was studied using both the free and encapsulated forms. A hollow pH-sensitive drug-delivery system was synthesized, characterized, and used to encapsulate and release the copper complex, thus allowing for the comparison with the free drug. Read More
ACS Omega 2018 Nov 13;3(11):15353-15360. Epub 2018 Nov 13.
Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Perfluorinated compounds (PFCs) are emerging persistent environmental contaminants that may be toxic to animals and humans. To gain fundamental insights into the mechanism of their toxicity, the interactions of phosphocholine (PC) liposomes as model membranes were studied with three types of PFCs, including perfluorooctanoic acid, perfluorooctane sulfonate, and perfluorohexanesulfonic acid potassium salt, together with three common surfactants: sodium dodecyl sulfate (SDS), cetyltrimethylammonium bromide (CTAB), and sodium 1-heptanesulfonate (SHS). The interactions were systematically characterized by zeta potential measurement, dynamic light scattering, negative-stain transmission electron microscopy, and fluorescence spectroscopy. Read More