117,234 results match your criteria Nutrition Metabolism & Cardiovascular Diseases [Journal]


Clinical Manifestations and Factors Associated with Osteosarcopenic Obesity Syndrome: A Cross-Sectional Study in Koreans with Obesity.

Calcif Tissue Int 2019 Apr 17. Epub 2019 Apr 17.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Simgokro 100Gil 25, Seo-gu, Incheon, 22711, South Korea.

Demonstrating the clinical consequences of osteosarcopenic obesity (OSO) is complex. This study evaluated clinical manifestations and factors associated with bone and muscle loss in Koreans with obesity. This cross-sectional observational study enrolled Koreans with obesity aged ≥ 50 years from the Korea National Health and Nutrition Examination Survey. Read More

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http://dx.doi.org/10.1007/s00223-019-00551-yDOI Listing

A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking.

Int J Legal Med 2019 Apr 17. Epub 2019 Apr 17.

INSERM, INRA, CHU Rennes, Institut NuMeCan (Nutrition, Metabolism and Cancer), University Rennes, 35000, Rennes, France.

Acebutolol is a β1-selective adrenergic receptor antagonist with moderate membrane-stabilizing activity and intrinsic sympathomimetic activity; accordingly, the drug is indicated in hypertension, angina pectoris, and arrhythmia. However, acebutolol's beta-blocking properties also extend the QRS and QTc intervals, and may predispose the patient to ventricular tachydysrhythmia. Here, we report autopsy and toxicological findings on a fatal case of acebutolol self-poisoning in a 70-year-old woman. Read More

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http://dx.doi.org/10.1007/s00414-019-02062-9DOI Listing

Hypoglycemia in People with Type 2 Diabetes and CKD.

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Kidney Research Institute.

Background And Objectives: Among people with diabetes mellitus, CKD may promote hypoglycemia through altered clearance of glucose-lowering medications, decreased kidney gluconeogenesis, and blunted counter-regulatory response. We conducted a prospective observational study of hypoglycemia among 105 individuals with type 2 diabetes treated with insulin or a sulfonylurea using continuous glucose monitors.

Design, Setting, Participants & Measurements: We enrolled 81 participants with CKD, defined as eGFR<60 ml/min per 1. Read More

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http://dx.doi.org/10.2215/CJN.11650918DOI Listing

Vitamin D supplementation partially affects colonic changes in dextran sulfate sodium-induced colitis obese mice but not lean mice.

Nutr Res 2019 Mar 20. Epub 2019 Mar 20.

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Republic of Korea; Research Institute of Human Ecology, College of Human Ecology, Seoul National University, Seoul, Republic of Korea. Electronic address:

Inflammatory bowel disease (IBD) often accompanies vitamin D deficiency, and vitamin D supplementation ameliorates IBD symptoms in animal models and humans. Because altered vitamin D metabolism has been reported in obesity, we hypothesized that the effects of vitamin D on the development of IBD would be different between obese and control mice. Five-week-old male C57BL/6N mice were divided into 4 groups and fed a diet differing in fat content (10% or 45%, normal diet [ND] or high-fat diet [HFD]) and vitamin D content (1000 or 10 000 IU/kg of diet, vDC or vDS) for 14 weeks. Read More

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http://dx.doi.org/10.1016/j.nutres.2019.03.009DOI Listing

Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Nutrients 2019 Apr 16;11(4). Epub 2019 Apr 16.

Section for Nutrition Research, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.

Supplementation with inulin-propionate ester (IPE), which delivers propionate to the colon, suppresses ad libitum energy intake and stimulates the release of satiety hormones acutely in humans, and prevents weight gain. In order to determine whether IPE remains effective when incorporated into food products (FP), IPE needs to be added to a widely accepted food system. A bread roll and fruit smoothie were produced. Read More

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https://www.mdpi.com/2072-6643/11/4/861
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http://dx.doi.org/10.3390/nu11040861DOI Listing
April 2019
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Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

The liver is the central organ of glycolipid metabolism, which regulates the metabolism of lipids and glucose to maintain energy homeostasis upon alterations of physiological conditions. Researchers formerly focused on the phosphorylation of glucagon in controlling liver metabolism. Noteworthily, emerging evidence has shown glucagon could additionally induce acetylation to control hepatic metabolism in response to different physiological states. Read More

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https://www.mdpi.com/1422-0067/20/8/1885
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http://dx.doi.org/10.3390/ijms20081885DOI Listing
April 2019
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Large cortical bone pores in the tibia are associated with proximal femur strength.

PLoS One 2019 17;14(4):e0215405. Epub 2019 Apr 17.

Berlin-Brandenburg Center for Regenerative Therapies, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Alterations of structure and density of cortical bone are associated with fragility fractures and can be assessed in vivo in humans at the tibia. Bone remodeling deficits in aging women have been recently linked to an increase in size of cortical pores. In this ex vivo study, we characterized the cortical microarchitecture of 19 tibiae from human donors (aged 69 to 94 years) to address, whether this can reflect impairments of the mechanical competence of the proximal femur, i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215405PLOS
April 2019
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Anterior Cruciate Ligament Tear Promotes Skeletal Muscle Myostatin Expression, Fibrogenic Cell Expansion, and a Decline in Muscle Quality.

Am J Sports Med 2019 Apr 17:363546519832864. Epub 2019 Apr 17.

Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, USA.

Background: Anterior cruciate ligament (ACL) tears result in significant quadriceps muscle atrophy that is resistant to recovery despite extensive rehabilitation. Recent work suggests an elevated fibrotic burden in the quadriceps muscle after the injury, which may limit recovery. Elucidating the mechanisms and cell types involved in the progression of fibrosis is critical for developing new treatment strategies. Read More

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http://dx.doi.org/10.1177/0363546519832864DOI Listing

Telehealth-Based Health Coaching Increases m-Health Device Adherence and Rate of Weight Loss in Obese Participants.

Telemed J E Health 2019 Apr 17. Epub 2019 Apr 17.

1 Department of Kinesiology, California State University, Long Beach, Long Beach, California.

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http://dx.doi.org/10.1089/tmj.2019.0017DOI Listing

l-carnitine and fat type in the maternal diet during gestation and lactation modify the fatty acid composition and expression of lipid metabolism-related genes in piglets.

J Anim Physiol Anim Nutr (Berl) 2019 Apr 17. Epub 2019 Apr 17.

Institute of Animal Nutrition, Northeast Agricultural University, Harbin, China.

This study examined the influence of adding different amounts of maternal dietary l-carnitine and two fat types on fatty acid (FA) composition and the expression of lipid metabolism-related genes in piglets. The experiment was designed as a 2 × 2 factorial with two fat types (3.5% soyabean oil, SO, and 3. Read More

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http://dx.doi.org/10.1111/jpn.13099DOI Listing

Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity.

Diabetes Metab J 2019 Apr;43(2):144-155

Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

Obstructive sleep apnea (OSA) and diabetes has been known to be closely related to each other and both diseases impact highly on the public health. There are many evidence of reports that OSA is associated with diabetes with a bidirectional correlation. A possible causal mechanism of OSA to diabetes is intermittent hypoxemia and diabetes to OSA is microvascular complication. Read More

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http://dx.doi.org/10.4093/dmj.2018.0256DOI Listing

Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey.

Clin Nutr 2019 Mar 25. Epub 2019 Mar 25.

Salford Royal NHS Foundation Trust, Salford, United Kingdom.

Background & Aims: The safety and effectiveness of a home parenteral nutrition (HPN) program depends both on the expertise and the management approach of the HPN center. We aimed to evaluate both the approaches of different international HPN-centers in their provision of HPN and the types of intravenous supplementation (IVS)-admixtures prescribed to patients with chronic intestinal failure (CIF).

Methods: In March 2015, 65 centers from 22 countries enrolled 3239 patients (benign disease 90. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193012
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http://dx.doi.org/10.1016/j.clnu.2019.03.010DOI Listing
March 2019
2 Reads

High intake of dietary fructose in overweight/obese teenagers associated with depletion of Eubacterium and Streptococcus in gut microbiome.

Gut Microbes 2019 Apr 16:1-8. Epub 2019 Apr 16.

a Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles , University of Southern California , Los Angeles , CA , USA.

Background: A western high fat, high carbohydrate diet has been shown to be associated with decreased gut bacterial diversity and reductions in beneficial bacteria. This gut bacteria dysbiosis could develop in early life and contribute to chronic disease risk such as obesity, type 2 diabetes and non-alcoholic fatty liver disease.

Objective: To determine how dietary macronutrients are associated with the relative abundance of gut bacteria in healthy adolescents. Read More

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https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1
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http://dx.doi.org/10.1080/19490976.2019.1592420DOI Listing
April 2019
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Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk.

Nutrients 2019 Apr 15;11(4). Epub 2019 Apr 15.

Center of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia.

Chokeberry polyphenols have been suggested to reduce cholesterol and blood pressure and thus protect against cardiovascular diseases (CVD), but the evidence in humans is limited and inconsistent. This randomized double-blinded three-parallel groups trial investigated the changes in various anthropometric and clinical biomarkers, and in plasma phospholipids fatty acids (PPFA) in volunteers at cardiovascular risk after a four-week intervention with 100 mL/day of (1) chokeberry juice with a high-dose of polyphenols (1177.11 mg gallic acid equivalents, GAE); (2) chokeberry juice with a low-dose of polyphenols (294. Read More

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http://dx.doi.org/10.3390/nu11040850DOI Listing

Hepatic DNA methylation and expression profiles under prenatal restricted diet in three generations of female rat fetuses.

PLoS One 2019 16;14(4):e0215471. Epub 2019 Apr 16.

Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Wojska Polskiego, Poznan, Poland.

The nutritional factors acting during early life can affect the development of the organism. It has been hypothesized that such programmed traits can be inherited by later generations. In this work, we present for the first time the effect of food deprivation in pregnant dams and its consequences for the transcription and DNA methylation profiles in the offspring of the next three generations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215471PLOS
April 2019
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Metabolomics Associated with Genome-Wide Association Study Related to the Basal Metabolic Rate in Overweight/Obese Korean Women.

J Med Food 2019 Apr 16. Epub 2019 Apr 16.

1 Research Division of Food Functionality, Korea Food Research Institute, Wanju-gun, Korea.

A previous genome-wide association study (GWAS) on obese/overweight Korean women reported five new genetic loci associated with the basal metabolic rate (BMR) and body mass index (BMI), , , , , and . This metabolite GWAS (mGWAS) aimed to identify the key metabolites and metabolic pathways regulated by these genes. Potential metabolic pathways associated with leanness and obesity were identified by detecting metabolites in association with GWAS. Read More

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http://dx.doi.org/10.1089/jmf.2018.4310DOI Listing

Lung function measurements in the prediabetes stage: data from the ILERVAS Project.

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

Aims: Patients with type 2 diabetes have been considered a susceptible group for pulmonary dysfunction. Our aim was to assess pulmonary function on the prediabetes stage.

Methods: Pulmonary function was assessed in 4,459 non-diabetic subjects, aged between 45 and 70 years, without cardiovascular disease or chronic pulmonary obstructive disease from the ongoing study ILERVAS. Read More

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http://link.springer.com/10.1007/s00592-019-01333-6
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http://dx.doi.org/10.1007/s00592-019-01333-6DOI Listing
April 2019
2 Reads

Correction to: Overweight and diabetes prevention: is a low-carbohydrate-high-fat diet recommendable?

Authors:
Fred Brouns

Eur J Nutr 2019 Apr 16. Epub 2019 Apr 16.

Department of Human biology, Faculty of Health, Medicine and Life Sciences, NUTRIM‑School of Nutrition and Translational Research in Metabolism, Maastricht University, Post Box 616, 6200 MD, Maastricht, The Netherlands.

In the original publication, the disclosure of potential conflicts of interest statement was not correct. Read More

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http://dx.doi.org/10.1007/s00394-019-01959-wDOI Listing

Underpowered or negative? A crucial distinction. Reply to Dollerup OL, Treebak JT, Jessen N [letter].

Diabetologia 2019 Apr 13. Epub 2019 Apr 13.

Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 50, P.O. Box 616, 6200 MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-019-4868-3DOI Listing
April 2019
1 Read

The Glycemic Index of Sport Nutrition Bars Affects Performance and Metabolism During Cycling and Next-Day Recovery.

J Hum Kinet 2019 Mar 27;66:69-79. Epub 2019 Mar 27.

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada, S7N 2Z4.

Low-glycemic index carbohydrates are potentially better for endurance performance as they result in greater fat oxidation and lower carbohydrate oxidation due to lower insulin release. We compared the effects of pre-exercise feeding with a low-glycemic index lentil-based sports nutrition bar, a commercially-available sports nutrition bar with moderate-glycemic index, and a non-caloric placebo on metabolism and performance during endurance cycling (Trial 1). Using a randomized, counterbalanced, crossover design, endurance-trained individuals (n = 11; eight males; 26 ± 6y; VO2peak 51. Read More

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http://dx.doi.org/10.2478/hukin-2018-0050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458587PMC

Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic mice.

Nutr Metab (Lond) 2019 2;16:22. Epub 2019 Apr 2.

Department of Physical Education, National Taiwan Normal University, 162, Section 1, Heping E. Rd, Taipei City, Taiwan.

Background: Chronic inflammation and metabolic dysregulation may eventually cause tissue damage in obesity-related diseases such as type 2 diabetes. The effects of SIRT1 on integration of metabolism and inflammation may provide a therapeutic target for treatment of obesity-related diseases. We examined the underlying mechanism of moderate intensity aerobic exercise on kidney and liver in obese diabetic mice, mainly focusing on inflammation and metabolic dysfunction. Read More

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http://dx.doi.org/10.1186/s12986-019-0349-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446356PMC

Effects of polymorphism in Ala54Thr on serum lipids and glycemic control in low glycemic index diets are associated with gender among Han Chinese with type 2 diabetes mellitus.

Diabetes Metab Syndr Obes 2019 27;12:413-421. Epub 2019 Mar 27.

Departments of Clinical Nutrition, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People's Republic of China,

Background/aims: Low glycemic index (GI) diets may have beneficial effects on glycemic control and serum lipid levels in patients with type 2 diabetes, but whether its effect is affected by polymorphisms of genes associated with lipid metabolism remains unclear. This study investigated whether the effects of a low-GI diet on serum lipids and glycemic control in patients with diabetes are associated with polymorphisms of Ala54Thr (rs1799883).

Methods: A retrospective study was conducted involving 165 patients with type 2 diabetes mellitus (T2DM) who participated in two completed trials. Read More

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http://dx.doi.org/10.2147/DMSO.S196738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441458PMC

Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway.

Aging (Albany NY) 2019 Apr 15. Epub 2019 Apr 15.

Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Shapingba District, Chongqing 400038, P. R. China.

Background: The concept of sarcopenic obesity refers to low muscle mass coupled with high adiposity in older adults. Sarcopenic obesity is a new medical challenge that imposes tremendous financial burdens on healthcare authorities worldwide. This study investigated the effects of resveratrol on high-fat diet-induced sarcopenic obesity in aged rats and palmitate acid-induced muscle atrophy in L6 myotubes and explored the underlying mechanisms. Read More

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http://dx.doi.org/10.18632/aging.101910DOI Listing

Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates.

J Biol Chem 2019 Apr 15. Epub 2019 Apr 15.

University of California Davis.

Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis associated () gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. However, adropin's roles in human metabolism are unclear. expression profiling in a nonhuman primate diurnal transcriptome atlas (GSE98965) revealed a dynamic and diurnal pattern of expression. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007528DOI Listing

Weight loss probiotic supplementation effect in overweight and obesity subjects: A review.

Clin Nutr 2019 Apr 3. Epub 2019 Apr 3.

Curso de Nutrição do Centro Universitário São Camilo, São Paulo, SP, Brazil; Brazilian Association of Sport Nutrition, São Paulo, SP, Brazil; Universidade de São Paulo, Programa de Pós-graduação em Nutrição em Saúde Pública, São Paulo, SP, Brazil. Electronic address:

Obese individuals present adverse changes in the diversity and composition of the gut microbiota, leading to alterations in energy balance, lipid metabolism, endocrine disturbances, and low-grade chronic systemic inflammation increases. Probiotic supplementation appears to change gut microbiota by decrease gut permeability, inflammation, and metabolic disorders, creating a promising environment to weight loss. This revision resumes the main findings of probiotic supplementation and weight loss that contributed to building the current background linking changes in gut microbiota profile and with obesity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193014
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http://dx.doi.org/10.1016/j.clnu.2019.03.034DOI Listing
April 2019
7 Reads

Household, maternal, and child related determinants of hemoglobin levels of Ethiopian children: hierarchical regression analysis.

BMC Pediatr 2019 Apr 15;19(1):113. Epub 2019 Apr 15.

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Anemia remains a major public health problem among children under five years old in Ethiopia, rising unexpectedly from 44% national prevalence in 2011 to 57% in 2016. In this study, we investigated the household, maternal and child-related dietary and non-dietary factors associated with hemoglobin (Hb) level of infants and young children.

Method: We analyzed data from a nationally representative sample of 2902 children aged 6-23 months, included in the 2016 Ethiopian demographic and health survey (EDHS). Read More

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http://dx.doi.org/10.1186/s12887-019-1476-9DOI Listing

Dietary acid load, kidney function and risk of Chronic Kidney Disease: A Systematic Review and Meta-analysis of Observational Studies.

Int J Vitam Nutr Res 2019 Apr 16:1-13. Epub 2019 Apr 16.

1 Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, Tehran, IR.

Aim: Study findings examining the association between dietary acid load (DAL), kidney function and risk of chronic kidney disease (CKD) are inconsistent and there has been no meta-analysis on the relationship between DAL, kidney function and risk of CKD, hence we investigated this association in this paper.

Methods: PubMed, ISI web of science and Scopus were searched up to January 2018 to identify all relevant articles. Effect sizes of eligible studies were pooled in random- effect model using the Der Simonian-Laird method. Read More

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http://dx.doi.org/10.1024/0300-9831/a000584DOI Listing

Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance.

Cancers (Basel) 2019 Apr 4;11(4). Epub 2019 Apr 4.

Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

A majority of breast cancer specific deaths in women with ERα (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to elucidate mechanisms of improved effectiveness of combined targeting of ERα and the nuclear transport protein XPO1 in overcoming endocrine resistance. Read More

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http://dx.doi.org/10.3390/cancers11040479DOI Listing

Genomic Analyses of Bifidobacterium moukalabense Reveal Adaptations to Frugivore/Folivore Feeding Behavior.

Microorganisms 2019 Apr 4;7(4). Epub 2019 Apr 4.

Chubu University Academy of Emerging Sciences, Kasugai, Aichi 487-8501, Japan.

Despite the essential role of in health-promoting gut bacteria in humans, little is known about their functions in wild animals, especially non-human primates. It is difficult to determine in vivo the function of Bifidobacterium in wild animals due to the limited accessibility of studying target animals in natural conditions. However, the genomic characteristics of obtained from the feces of wild animals can provide insight into their functionality in the gut. Read More

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http://dx.doi.org/10.3390/microorganisms7040099DOI Listing

Plasma Malondialdehyde and Risk of New-Onset Diabetes after Transplantation in Renal Transplant Recipients: A Prospective Cohort Study.

J Clin Med 2019 Apr 4;8(4). Epub 2019 Apr 4.

Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. Read More

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http://dx.doi.org/10.3390/jcm8040453DOI Listing

Continuous Renal Replacement Therapy with High Flow Rate Can Effectively, Safely, and Quickly Reduce Plasma Ammonia and Leucine Levels in Children.

Children (Basel) 2019 Apr 4;6(4). Epub 2019 Apr 4.

Department of Pediatric Intensive Care Unit, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Fatih, Istanbul 34098, Turkey.

: Peritoneal dialysis and continuous renal replacement therapy (CRRT) are the most frequently used treatment modalities for acute kidney injury. CRRT is currently being used for the treatment of several non-renal indications, such as congenital metabolic diseases. CRRT can efficiently remove toxic metabolites and reverse the neurological symptoms quickly. Read More

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http://dx.doi.org/10.3390/children6040053DOI Listing

Eradication Treatment Alters Gut Microbiota and GLP-1 Secretion in Humans.

J Clin Med 2019 Apr 4;8(4). Epub 2019 Apr 4.

Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital (IBIMA), Malaga University, 29010 Malaga, Spain.

Changes in the intestinal microbial community and some metabolic disturbances, including obesity and type2 diabetes, are related. Glucagon-like peptide-1 (GLP-1) regulates glucose homeostasis. Microbiota have been linked to incretin secretion. Read More

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http://dx.doi.org/10.3390/jcm8040451DOI Listing

Ameliorative Effect of Spinach on Non-Alcoholic Fatty Liver Disease Induced in Rats by a High-Fat Diet.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Department of Food Technology, Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence "Campus Mare Nostrum", Biomedical Research Institute of Murcia (IMIB-Arrixaca-UMU), University Clinical Hospital "Virgen de la Arrixaca", University of Murcia, Espinardo, 30071 Murcia, Spain.

The purpose of this work was to evaluate the effect of dietary carotenoids from spinach on the inflammation and oxidative stress biomarkers, liver lipid profile, and liver transcriptomic and metabolomics profiles in Sprague-Dawley rats with steatosis induced by a high-fat diet. Two concentrations of spinach powder (2.5 and 5%) were used in two types of diet: high-fat (H) and standard (N). Read More

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http://dx.doi.org/10.3390/ijms20071662DOI Listing

Effects of the Chiral Fungicides Metalaxyl and Metalaxyl-M on the Earthworm as Determined by ¹H-NMR-Based Untargeted Metabolomics.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing 100193, China.

Although metalaxyl and metalaxyl-M are widely used fungicides, very little is known about their subacute and enantiospecific effects on the earthworm metabolome. In this study, were exposed to metalaxyl and metalaxyl-M at three concentrations (0.5, 5 and 50 mg/kg) for seven days. Read More

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http://dx.doi.org/10.3390/molecules24071293DOI Listing

Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis.

Int J Mol Sci 2019 Apr 2;20(7). Epub 2019 Apr 2.

Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden.

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in western countries. Despite the high prevalence of NAFLD, the underlying biology of the disease progression is not clear, and there are no approved drugs to treat non-alcoholic steatohepatitis (NASH), the most advanced form of the disease. Thus, there is an urgent need for developing advanced in vitro human cellular systems to study disease mechanisms and drug responses. Read More

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https://www.mdpi.com/1422-0067/20/7/1629
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http://dx.doi.org/10.3390/ijms20071629DOI Listing
April 2019
1 Read

Effect of non-surgical periodontal therapy on insulin resistance and insulin sensitivity among individuals with borderline diabetes: A randomized controlled trial.

J Dent 2019 Apr 12. Epub 2019 Apr 12.

Department of Public Health and Epidemiology, Faculty of Medicine, Oita University 1-1 Idaigaoka, Hasama-machi, Yufu-shi Oita, 879-5593, Japan. Electronic address:

Objective: To investigate the effect of non-surgical periodontal therapy on insulin resistance and sensitivity among individuals with borderline diabetes not receiving medications.

Methods: A crossover, randomized controlled trial was conducted among participants with borderline diabetes diagnosed by a 75-g oral glucose tolerance test. Participants were randomly assigned to either an early or later intervention group. Read More

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http://dx.doi.org/10.1016/j.jdent.2019.04.005DOI Listing

Glycated Hemoglobin, but not Insulin Sensitivity, is Associated with Memory in Subjects with Obesity.

Obesity (Silver Spring) 2019 Apr 15. Epub 2019 Apr 15.

Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute, Dr. Josep Trueta University Hospital, Center for Physiopathology of Obesity and Nutrition, Girona, Spain.

Objective: Obesity has been related to later-life dementia. Serum glucose levels and insulin resistance are known to influence cognition in individuals with diabetes. This study aimed to evaluate memory function in middle-aged individuals with obesity in association with glucose metabolism and brain iron content. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.22457
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http://dx.doi.org/10.1002/oby.22457DOI Listing
April 2019
1 Read

Valine increases milk fat synthesis in mammary gland of gilts through stimulating AKT/MTOR/SREBP1 pathway‡.

Biol Reprod 2019 Apr 15. Epub 2019 Apr 15.

Key Laboratory of Animal Disease-Resistance Nutrition and Feed Science, Ministry of Agriculture, P. R. China, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, 611130, China.

Lactating mammary glands are among the most active lipogenic organs and provide a large percentage of bioactive lipids and calories for infant growth. The branched-chain amino acid (BCAA) valine is known to modulate fatty acids synthesis in adipose tissue; however, its effects on fat metabolism and the underlying mechanisms in mammary glands remain to be determined. Valine supplementation during late pregnancy significantly increased the contents of total milk fat, triglyceride, sphingomyelin, and polyunsaturated fatty acids in the colostrum of gilts. Read More

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http://dx.doi.org/10.1093/biolre/ioz065DOI Listing

Measuring What Matters in Diabetes.

JAMA 2019 Apr 15. Epub 2019 Apr 15.

Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.4310DOI Listing
April 2019
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Hyponatremia secondary to severe atopic dermatitis in early infancy.

Pediatr Int 2019 Apr 15. Epub 2019 Apr 15.

Department of Allergy, Kanagawa Children's Medical Center, Yokohama, Japan.

Background: Infants with atopic dermatitis who developed hyponatremia and hyperkalemia with raised aldosterone level have been repeatedly described in Japanese domestic literatures. However, similar reports from other countries are scarce.

Methods: Including our experiences, we collected reports of atopic dermatitis complicated with hyponatremia (≤130 mEq/L), written either in English or in Japanese, to delineate the characteristics and to elucidate the pathophysiology of this condition. Read More

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http://dx.doi.org/10.1111/ped.13865DOI Listing
April 2019
2 Reads

Effects of omega-3 polyunsaturated fatty acids on steroidogenesis and cellular development in PCOS rats.

Food Funct 2019 Apr 15. Epub 2019 Apr 15.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, Peoples' Republic of China. and College of Life Science, Capital Normal University, Beijing 100048, Peoples' Republic of China.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, which is characterized by hyperandrogenism. Polyunsaturated fatty acids (PUFAs) are necessary for the body's metabolism, growth and development. Despite the well-known benefits of omega-3 polyunsaturated fatty acid supplementation on the modulation of PCOS ovarian function, relatively little is known about the precise regulation mechanism. Read More

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http://dx.doi.org/10.1039/c8fo02319kDOI Listing

Development of a food-based index of dietary inflammatory potential for Koreans and its relationship with metabolic syndrome.

Nutr Res Pract 2019 Apr 22;13(2):150-158. Epub 2019 Mar 22.

Department of Food and Nutrition, Wonkwang University, 460, Iksan-daero, Iksan-si, Jeonbuk, 54538, Republic of Korea.

Background/objectives: Inflammation is known to be a risk factor for metabolic diseases. This study aimed to develop a Food-based Index of Dietary Inflammatory Potential (FBDI) and examine its association with metabolic biomarkers.

Subjects/methods: This study analyzed the raw data from the 2012-2014 Korean Genome and Epidemiology Study data of 17,771 people. Read More

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http://dx.doi.org/10.4162/nrp.2019.13.2.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449546PMC

Fungal Community Structural and Microbial Functional Pattern Changes After Soil Amendments by Oilseed Meals of and : A Microcosm Study.

Front Microbiol 2019 29;10:537. Epub 2019 Mar 29.

Department of Soil and Crop Sciences, Texas A&M University, College Station, TX, United States.

The meals after oil extraction from many oilseed crops have nutrition and biofumigation potential for land application. Oilseed meal (SM) from the dedicated bioenergy crop were implicated to contain compounds that have antibacterial properties on some soil pathogens. However, little is known about its effect on non-targeted soil microbial community, especially on fungi. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450180PMC

Revisiting the Role of Exercise Countermeasure on the Regulation of Energy Balance During Space Flight.

Front Physiol 2019 29;10:321. Epub 2019 Mar 29.

Université de Strasbourg, Centre National de la Recherche Scientifique, Institut Pluridisciplinaire Hubert Curien UMR 7178, Strasbourg, France.

A body mass loss has been consistently observed in astronauts. This loss is of medical concern since energy deficit can exacerbate some of the deleterious physiological changes observed during space flight including cardiovascular deconditioning, bone density, muscle mass and strength losses, impaired exercise capacity, and immune deficiency among others. These may jeopardize crew health and performance, a healthy return to Earth and mission's overall success. Read More

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http://dx.doi.org/10.3389/fphys.2019.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449861PMC

Low-calorie sweetener use, weight, and metabolic health among children: A mini-review.

Pediatr Obes 2019 Apr 14:e12521. Epub 2019 Apr 14.

Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.

A reduction in the consumption of added sugars and sugar-sweetened beverages (SSBs) is a key focus of public health recommendations for a healthy diet among children. One approach to lower added sugar intake is to instead use low-calorie sweeteners (LCSs), which contain no or few calories. Consumption of LCSs is increasing worldwide, with the most marked rise observed among children and adolescents. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijpo.12521
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http://dx.doi.org/10.1111/ijpo.12521DOI Listing
April 2019
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Efficacy and safety of Rhizoma curcumea longae with respect to improving the glucose metabolism of patients at risk for cardiovascular disease: a meta-analysis of randomised controlled trials.

J Hum Nutr Diet 2019 Apr 14. Epub 2019 Apr 14.

Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Clinical evidence suggests that curcuminoids, as a natural polyphenol, can provide support for cardioprotection and glucose metabolism. This meta-analysis assessed the efficacy and safety of curcumin with respect to improving glucose metabolism in patients with cardiovascular risk factors.

Methods: Four databases (PubMed, Cochrane Library, Web of Science and Embase) were searched up to June 2018. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jhn.12648
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http://dx.doi.org/10.1111/jhn.12648DOI Listing
April 2019
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Salivary α-amylase copy number is not associated with weight trajectories and glycemic improvements following clinical weight loss: results from a 2-phase dietary intervention study.

Am J Clin Nutr 2019 Apr;109(4):1029-1037

Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.

Background: Several studies recently reported contradicting results regarding the link between amylase 1 (AMY1) copy numbers (CNs), obesity, and type 2 diabetes.

Objective: The aim of this study was to assess the impact of AMY1 CN on anthropometrics and glycemic outcomes in obese individuals following a 2-phase dietary weight loss intervention.

Methods: Using the paralog ratio test, AMY1 CNs were accurately measured in 761 obese individuals from the DiOGenes study. Read More

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http://dx.doi.org/10.1093/ajcn/nqy363DOI Listing

Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies.

Am J Clin Nutr 2019 Apr;109(4):1216-1223

Cardiovascular Health Research Unit.

Background: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed.

Objective: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. Read More

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http://dx.doi.org/10.1093/ajcn/nqz005DOI Listing
April 2019
6.770 Impact Factor

The Metabolic Map into the Pathomechanism and Treatment of PGM1-CDG.

Am J Hum Genet 2019 Apr 2. Epub 2019 Apr 2.

Metabolomics Expertise Center, Center for Cancer Biology, VIB Center for Cancer Biology, 3000 Leuven, Belgium; Metabolomics Expertise Center, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium. Electronic address:

Phosphoglucomutase 1 (PGM1) encodes the metabolic enzyme that interconverts glucose-6-P and glucose-1-P. Mutations in PGM1 cause impairment in glycogen metabolism and glycosylation, the latter manifesting as a congenital disorder of glycosylation (CDG). This unique metabolic defect leads to abnormal N-glycan synthesis in the endoplasmic reticulum (ER) and the Golgi apparatus (GA). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029297193009
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http://dx.doi.org/10.1016/j.ajhg.2019.03.003DOI Listing
April 2019
1 Read
10.931 Impact Factor

No Difference in Magnesium Intake between Obese Women and Healthy Controls.

Int J Vitam Nutr Res 2019 Apr 15:1-7. Epub 2019 Apr 15.

1 Department of Nutrition, Federal University of Piauí, Ministro Petrônio Portella Campus, Ininga, Teresina, Piauí, Brazil.

Magnesium is a predominantly intracellular ion and plays an important role in energy metabolism and in the maintenance of energy homeostasis. This study aimed to estimate the dietary intake of magnesium and its association with adiposity parameters in obese women. This cross-sectional study included 125 women, aged between 20 and 50 years, who were divided into two groups: obese group (n = 62) and control group (n = 63). Read More

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http://dx.doi.org/10.1024/0300-9831/a000413DOI Listing