115,454 results match your criteria Nutrition Metabolism & Cardiovascular Diseases [Journal]


Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression.

Chem Biol Interact 2019 Feb 19. Epub 2019 Feb 19.

Department of Nutrition, UNC-Chapel Hill, UNC Nutrition Research Institute, Kannapolis, NC, 28081, United States.

ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is the enzyme in folate metabolism commonly downregulated in human cancers. One of the mechanisms of the enzyme downregulation is methylation of the promoter of the ALDH1L1 gene. Recent studies underscored ALDH1L1 as a candidate tumor suppressor and potential marker of aggressive cancers. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.013DOI Listing
February 2019

RESEARCH IN NUTRITIONAL SUPPLEMENTS AND NUTRACEUTICALS FOR HEALTH, PHYSICAL ACTIVITY AND PERFORMANCE: MOVING FORWARD.

Appl Physiol Nutr Metab 2019 Feb 22. Epub 2019 Feb 22.

Canadian Sport Institute Pacific , Victoria, British Columbia, Canada ;

This Horizons is part of a series which identifies key, forward-thinking research questions and challenges that need to be addressed. Specifically, this Horizons paper discusses research in nutritional supplements and nutraceuticals for health, physical activity and performance, and is the product of a discussion by an expert panel that took place in January 2018 prior to the Canadian Nutrition Society Thematic Conference "Advances in Sport Nutrition from Daily Living to High Performance Sport". The objective of this Horizons was to identify core considerations for future studies for this research area, and how scientists can be leaders in the field to ensure the best quality science is available for decision makers. Read More

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http://dx.doi.org/10.1139/apnm-2018-0781DOI Listing
February 2019

Inhibition of P53/miR-34a improves diabetic endothelial dysfunction via activation of SIRT1.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Toxicology and Nutrition, School of Public Health, Shandong University, Jinan, Shandong, China.

Endothelial dysfunction contributes to diabetic macrovascular complications, resulting in high mortality. Recent findings demonstrate a pathogenic role of P53 in endothelial dysfunction, encouraging the investigation of the effect of P53 inhibition on diabetic endothelial dysfunction. Thus, high glucose (HG)-treated endothelial cells (ECs) were subjected to pifithrin-α (PFT-α)-a specific inhibitor of P53, or P53-small interfering RNA (siRNA), both of which attenuated the HG-induced endothelial inflammation and oxidative stress. Read More

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http://dx.doi.org/10.1111/jcmm.14253DOI Listing
February 2019

Liver cancer: WISP3 suppresses hepatocellular carcinoma progression by negative regulation of β-catenin/TCF/LEF signalling.

Cell Prolif 2019 Feb 22:e12583. Epub 2019 Feb 22.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

Objectives: Wnt1-inducible signalling pathway protein 3 (WISP3/CCN6) belongs to the CCN (CYR61/CTGF/NOV) family of proteins, dysregulation of this family contributed to the tumorigenicity of various tumours. In this study, we need to explore its role in hepatocellular carcinoma that remains largely elusive.

Materials And Methods: The expression of WISP3/CCN6 was analysed by qRT-PCR and Western blotting. Read More

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http://dx.doi.org/10.1111/cpr.12583DOI Listing
February 2019

Vitamin D for the Immune System in Cystic Fibrosis (DISC): a double-blind, multicenter, randomized, placebo-controlled clinical trial.

Am J Clin Nutr 2019 Feb 22. Epub 2019 Feb 22.

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA.

Background: Patients with cystic fibrosis (CF) have increased risk of vitamin D deficiency owing to fat malabsorption and other factors. Vitamin D deficiency has been associated with increased risk of pulmonary exacerbations of CF.

Objectives: The primary objective of this study was to examine the impact of a single high-dose bolus of vitamin D3 followed by maintenance treatment given to adults with CF during an acute pulmonary exacerbation on future recurrence of pulmonary exacerbations. Read More

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http://dx.doi.org/10.1093/ajcn/nqy291DOI Listing
February 2019

Sex Differences in Nutrition, Growth, and Metabolism in Preterm Infants.

Authors:
Pradeep Alur

Front Pediatr 2019 7;7:22. Epub 2019 Feb 7.

Division of Neonatology, Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, United States.

Biological differences between the sexes are apparent even from the early part of the pregnancy. The crown-rump length is larger in male fetuses compared to females in the first trimester. Placentae of male and female fetuses have different protein and gene expressions, especially in adverse conditions. Read More

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http://dx.doi.org/10.3389/fped.2019.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374621PMC
February 2019

Involvement of PPARγ/FSP27 in the pathogenic mechanism underlying insulin resistance: tipping the balance between lipogenesis and fat storage in adult catch-up growth rats.

Nutr Metab (Lond) 2019 11;16:11. Epub 2019 Feb 11.

3Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 People's Republic of China.

Background: Catch-up growth in adult (CUGA) is characterized by visceral fat accumulation, ectopic lipid deposition and insulin resistance (IR). Here, we investigated the determinants of these pathophysiological consequences of CUGA.

Methods: Rats were divided into different groups: control rats were offered normal chow ad libitum (AL), while experimental rats were put on 4-week caloric restriction (CR) initially, followed by regaining weight-matched normal chow (RN) in the RN group. Read More

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http://dx.doi.org/10.1186/s12986-019-0336-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371468PMC
February 2019

Lactate Degradation Pattern Shifts in Rumen Acidosis Models.

Front Microbiol 2019 7;10:162. Epub 2019 Feb 7.

Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

is an ecologically important rumen bacterium that metabolizes lactate and relieves rumen acidosis (RA) induced by a high-grain-diet. Understanding the regulatory mechanisms of the lactate metabolism of this species in RA conditions might contribute to developing dietary strategies to alleviate RA. was co-cultured with four lactate producers (, , , and ) and a series of substrate starch doses (1, 3, and 9 g/L) were used to induce one normal and two RA models (subacute rumen acidosis, SARA and acute rumen acidosis, ARA) under batch conditions. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374331PMC
February 2019

Epigenome-wide association study in peripheral white blood cells involving insulin resistance.

Sci Rep 2019 Feb 21;9(1):2445. Epub 2019 Feb 21.

University of Navarra, Department of Nutrition, Food Sciences and Physiology & Centre for Nutrition Research, Pamplona, Spain.

Insulin resistance (IR) is a hallmark of type 2 diabetes, metabolic syndrome and cardiometabolic risk. An epigenetic phenomena such as DNA methylation might be involved in the onset and development of systemic IR. The aim of this study was to explore the genetic DNA methylation levels in peripheral white blood cells with the objective of identifying epigenetic signatures associated with IR measured by the Homeostatic Model Assessment of IR (HOMA-IR) following an epigenome-wide association study approach. Read More

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http://dx.doi.org/10.1038/s41598-019-38980-2DOI Listing
February 2019

The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life.

Sci Rep 2019 Feb 21;9(1):2434. Epub 2019 Feb 21.

Laboratory of Microbiology, Wageningen University & Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.

Gastrointestinal (GI) microbiota composition differs between breastfed and formula-fed infants. Today's infant formulas are often fortified with prebiotics to better mimic properties of human milk with respect to its effect on GI microbiota composition and function. We used Illumina HiSeq sequencing of PCR-amplified 16S rRNA gene fragments to investigate the composition of faecal microbiota in 2-12 week old infants receiving either breastmilk, infant formulas fortified with prebiotics, or mixed feeding. Read More

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http://dx.doi.org/10.1038/s41598-018-38268-xDOI Listing
February 2019

Dietary supplement of tomato can accelerate urinary aMT6s level and improve sleep quality in obese postmenopausal women.

Clin Nutr 2019 Feb 10. Epub 2019 Feb 10.

Department of Nutrition and Health Sciences, Taipei Medical University, Taipei, 11031, Taiwan; Graduate Institute of Metabolism and Obesity, College of Nutrition, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address:

The aim of this study was to investigate the effect of the ingestion of tomato before bed on obese postmenopausal women's urinary 6-sulphatoxymelatonin (aMT6s) level and sleep quality. We quantified melatonin concentrations in beefsteak tomato, black tomato, and two commercial tomato juices and found that beefsteak tomato contained the highest level of melatonin. In this 8-week open-label, randomized controlled dietary intervention trial, 36 subjects completed the entire trial. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.02.009DOI Listing
February 2019

Recognition of alpha-mannosidosis in paediatric and adult patients: Presentation of a diagnostic algorithm from an international working group.

Mol Genet Metab 2019 Jan 31. Epub 2019 Jan 31.

University Medical Center Mainz, Dept. of Pediatric and Adolescent Medicine, Mainz, Germany.

Alpha-mannosidosis is an ultra-rare progressive lysosomal storage disorder caused by deficiency of alpha-mannosidase. Timely diagnosis of the disease has the potential to influence patient outcomes as preventive therapies can be initiated at an early stage. However, no internationally-recognised algorithm is currently available for the diagnosis of the disease. Read More

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http://dx.doi.org/10.1016/j.ymgme.2019.01.024DOI Listing
January 2019

Concurrent anemia and stunting in young children: prevalence, dietary and non-dietary associated factors.

Nutr J 2019 Feb 21;18(1):10. Epub 2019 Feb 21.

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: The existing evidence is limited and contradicting on the co-occurrence of anemia and stunting (CAS) at individual level, despite a great overlap in their risk factors. We aimed to determine the prevalence of CAS, and the dietary and non-dietary factors associated with it, among infants and young children in Ethiopia.

Method: We used a nationally representative sample of 2902 children aged 6-23 months from the Ethiopian demographic and health survey, conducted in 2016. Read More

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http://dx.doi.org/10.1186/s12937-019-0436-4DOI Listing
February 2019

Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels.

Nutrients 2019 Feb 20;11(2). Epub 2019 Feb 20.

Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.

Phosphorus (P) is an important element of various metabolic and signalling processes, including bone metabolism and immune function. To elucidate the routes of P homeostasis and utilization, a five-week feeding study was conducted with weaned piglets receiving a diet with recommended amounts of P and Ca (M), or a diet with lower (L) or higher (H) P values and a constant Ca:P ratio. Routes of P utilization were deduced via bone characteristics (MicroCT), genome-wide transcriptomic profiles of peripheral blood mononuclear cells (PBMCs), and serum mineral levels. Read More

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http://dx.doi.org/10.3390/nu11020436DOI Listing
February 2019

Anxiety symptoms and emotional eating are independently associated with sweet craving in young adults.

Psychiatry Res 2019 Jan 3;271:715-720. Epub 2018 Dec 3.

Division of Nutrition and Metabolism, Department of Health Sciences. Ribeirão Preto Medical Scholl. Universidade de São Paulo. Av. Bandeirantes, 3900. Bairro Monte Alegre, CEP 14049-900 Ribeirão Preto, SP, Brazil; Laboratory of Eating Practices and Behavior (PratiCA), Universidade de São Paulo, Av. Bandeirantes, 3900. Bairro Monte Alegre, CEP 14049-900 Ribeirão Preto, SP, Brazil. Electronic address:

Sweet craving (SC), defined as a strong desire for sweet foods, seems to be closely related to negative emotions, such as anxiety and unhealthy eating behaviors. The objective was to investigate factors that are associated with SC and to assess the relationships among SC, anxiety symptoms, and eating behavior in university students. This was a cross-sectional study involving 300 students of both sexes (20. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.11.070DOI Listing
January 2019

Possible molecular mechanisms of glucose-lowering activities of Momordica charantia (karela) in diabetes.

J Cell Biochem 2019 Feb 20. Epub 2019 Feb 20.

Department of Modern Sciences and Technology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Diabetes mellitus is a highly prevalent metabolic disorder which is characterized by impaired glucose tolerance, with a relative or absolute insulin deficiency and profound changes in the metabolism of macronutrients. Traditional and complementary medicine is therapeutic strategies that have both been applied to improving glycemic control. Momordica charantia is one of the plant-based, folk medicines that used for improving glycemic control. Read More

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http://dx.doi.org/10.1002/jcb.28483DOI Listing
February 2019

Feasibility and safety of extracorporeal CO removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study.

Intensive Care Med 2019 Feb 21. Epub 2019 Feb 21.

Alma Mater Studiorum - Università di Bologna, Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Policlinico di Sant'Orsola, Via Massarenti, 9, 40138, Bologna, Italy.

Purpose: We assessed feasibility and safety of extracorporeal carbon dioxide removal (ECCOR) to facilitate ultra-protective ventilation (V 4 mL/kg and P ≤ 25 cmHO) in patients with moderate acute respiratory distress syndrome (ARDS).

Methods: Prospective multicenter international phase 2 study. Primary endpoint was the proportion of patients achieving ultra-protective ventilation with PaCO not increasing more than 20% from baseline, and arterial pH > 7. Read More

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http://dx.doi.org/10.1007/s00134-019-05567-4DOI Listing
February 2019

Quantitation of 5-methyltetraydrofolic acid in plasma for determination of folate status and clinical studies by stable isotope dilution assays.

PLoS One 2019 21;14(2):e0212255. Epub 2019 Feb 21.

Chair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.

Folates play a key role in the prevention of neural tube defects in newborns. Thus, it is important to reliably determine the bioavailability of folates from various foods. Accurate analytical methods are essential for quantifying blood-folates, especially in human studies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212255PLOS
February 2019

Palm Oil and Beta-Palmitate in Infant Formula - A Position Paper by the ESPGHAN Committee on Nutrition.

J Pediatr Gastroenterol Nutr 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Background: Palm oil (PO) is used in infant formulas in order to achieve palmitic acid (PA) levels similar to those in human milk. PA in PO is esterified predominantly at the SN-1,3 position of triacylglycerol (TAG), and infant formulas are now available in which a greater proportion of PA is in the SN-2 position (typical configuration in human milk). Since there are some concerns about the use of PO, we aimed to review literature on health effects of PO and SN-2-palmitate in infant formulas. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002307DOI Listing
February 2019

Antioxidants for Pancreatic Functions in Chronic Pancreatitis: A Double-blind Randomized Placebo-controlled Pilot Study.

J Clin Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Department of Gastroenterology and Human Nutrition Unit.

Background: Antioxidants (AO) supplementation in chronic pancreatitis (CP) has been evaluated for pain. But it is not clear whether AO in CP have an effect on pancreatic functions and other clinical outcomes. We evaluated effect of AO on endocrine function in CP. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001178DOI Listing
February 2019

Obesity is associated with folate metabolism.

Int J Vitam Nutr Res 2019 Feb 21:1-12. Epub 2019 Feb 21.

1 Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics, 06560 Beşevler, Ankara, Turkey.

Objective: The aim of the present study is to perform a systemic review of the previous studies executed on the association between obesity and folate.

Method: In the present research, the selected keywords were scanned on the PubMed, Web of Science, Cochrane and Lilac databases between May and June, 2017 through Gazi University's network. In total, 4236 clinical, randomized controlled, cross-sectional and prospective studies were determined and 17 of these that specifically fit the aims of the present research were reviewed. Read More

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http://dx.doi.org/10.1024/0300-9831/a000515DOI Listing
February 2019

Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion.

FASEB J 2019 Feb 21:fj201801783RR. Epub 2019 Feb 21.

Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Our previous study demonstrated that sphingosine kinase 1-interacting protein (SKIP, or Sphkap) is expressed in pancreatic β-cells, and depletion of SKIP enhances glucose-stimulated insulin secretion. We find here that SKIP is also expressed in intestinal K- and L-cells and that secretion of gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) as well as insulin are significantly increased, and blood glucose levels are decreased in SKIP-deficient (SKIP) mice compared with those in wild-type mice. Plasma triglyceride (Tg), LDL cholesterol, and mRNA levels of proinflammatory cytokines in adipose tissues, livers, and intestines were found to be significantly decreased in SKIP mice. Read More

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http://dx.doi.org/10.1096/fj.201801783RRDOI Listing
February 2019

Attenuating effects of guanidinoacetic acid on preslaughter transport-induced muscle energy expenditure and rapid glycolysis of broilers.

Poult Sci 2019 Feb 21. Epub 2019 Feb 21.

College of Animal Science and Technology, Jiangsu Provincial Key Laboratory of Animal Origin Food Production and Safety Guarantee, Jiangsu Provincial Key Laboratory of Gastrointestinal Nutrition and Animal Health, Jiangsu Provincial Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China.

This study evaluated the effects of dietary guanidinoacetic acid (GAA) supplementation on growth performance, plasma variables, muscle energy status, glycolytic potential, and meat quality of broilers experiencing transport stress during the summer. A total of 320 28-day-old male Arbor Acres broilers were randomly allotted to 3 dietary treatments, including a GAA-free basal control diet (160 birds) and basal diet supplementation with 600 (80 birds) or 1,200 mg/kg (80 birds) GAA for 14 D. On the morning of day 42, after an 8-h fast, the birds fed basal diets were divided into 2 equal groups, and all birds in the 4 groups of 80 birds were transported according to the following protocols: 1) a 0. Read More

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http://dx.doi.org/10.3382/ps/pez052DOI Listing
February 2019

Differences in the cluster of depressive symptoms between subjects with type 2 diabetes and individuals with a major depressive disorder and without diabetes.

J Endocrinol Invest 2019 Feb 20. Epub 2019 Feb 20.

Endocrinology and Nutrition Department, Hospital Son Llàtzer, University Institute of Health Science Research (IUNICS) and Health Research Institute of Palma (IdISPa), Ctra Manacor km 4, 07198, Palma de Mallorca, Baleares, Spain.

Background: Depressive disorder encompasses a wide spectrum of somatic and psychological symptoms. It is not known whether there are differences regarding the cluster of depressive symptomatology between subjects with depression with and without T2DM.

Purpose: To explore whether the cluster of depression that prevails among depressive subjects with T2DM differs from individuals with depression, but without T2DM. Read More

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http://dx.doi.org/10.1007/s40618-019-01020-xDOI Listing
February 2019

Nutritional regulation of pyruvate kinase and phosphoenolpyruvate carboxykinase at the enzymatic and molecular levels in cobia Rachycentron canadum.

Fish Physiol Biochem 2019 Feb 20. Epub 2019 Feb 20.

Life Science College, East China Normal University, Shanghai, China.

Despite being a carnivorous fish species, cobia (Rachycentron canadum) can utilize high levels of dietary carbohydrate (up to 360 g kg). By contrast, rainbow trout (also carnivorous) cannot, due to the absence of molecular induction of glycolytic enzyme and inhibition of gluconeogenic enzyme gene expressions such as pyruvate kinase (PK) and phosphoenolpyruvate carboxykinase (PEPCK). We hypothesized that this phenomenon is species-specific and will not be observed in cobia. Read More

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http://dx.doi.org/10.1007/s10695-019-00612-xDOI Listing
February 2019

Depressive symptoms among metabolically healthy and unhealthy overweight/obese individuals: a comparative study.

Med J Islam Repub Iran 2018 1;32:95. Epub 2018 Oct 1.

Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Although a growing body of evidence suggests an association between obesity and depressive disorder, the association remains inconclusive. Metabolically healthy obese (MHO) phenotype, defined by favorable lipid profile, and normal insulin sensitivity, blood pressure, may be considered as a possible explanation for these inconsistencies. Accordingly, this study aimed to compare depression score among metabolic unhealthy obese (MUO) and age- and sex-matched healthy controls. Read More

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http://dx.doi.org/10.14196/mjiri.32.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377003PMC
October 2018

The protective effect of Boiss. hydroalcoholic extract on TNF-α production, oxidative stress, and insulin level in streptozotocin-induced diabetic rats.

Avicenna J Phytomed 2019 Jan-Feb;9(1):72-83

Department of Endocrinology, Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: Oxidative stress leads to reactive oxygen species (ROS) overproduction, which causes tissue injury in diabetic patients. The aim of this study was to evaluate the effects of extract on TNF-α, oxidative stress products, and insulin levels as well as lipid profile in diabetic rats.

Materials And Methods: Rats were randomly divided into 6 groups of 10 animals. Read More

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February 2019

Walnut phenolic extracts reduce telomere length and telomerase activity in a colon cancer stem cell model.

Nutr Res Pract 2019 Feb 3;13(1):58-63. Epub 2018 Dec 3.

CHA University School of Medicine, 120, Haeryong-ro, Pocheon-si, Gyeonggi 13488, Korea.

Background/objectives: Telomeres are located at the chromosomal ends and progressively shortened during each cell cycle. Telomerase, which is regulated by and -, maintains telomeric DNA sequences. Especially, telomerase is active in cancer and stem cells to maintain telomere length for replicative immortality. Read More

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http://dx.doi.org/10.4162/nrp.2019.13.1.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369112PMC
February 2019

Dietary Lysozyme Alters Sow's Gut Microbiota, Serum Immunity and Milk Metabolite Profile.

Front Microbiol 2019 6;10:177. Epub 2019 Feb 6.

Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences - National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production - Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production - Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, China.

The aim of current study was to determine variations in sow's gut microbiota, serum immunity, and milk metabolite profile mediated by lysozyme supplementation. Twenty-four pregnant sows were assigned to a control group without supplementation and two treatments with 0.5 kg/t and 1. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373202PMC
February 2019

Improving Cognitive Performance of 9-12 Years Old Children: Just Dance? A Randomized Controlled Trial.

Front Psychol 2019 6;10:174. Epub 2019 Feb 6.

Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Exercise is assumed to have positive effects on children's cognitive performance. However, given the inconclusive evidence for the long-term effects of exercise, it is difficult to advice schools on what specific exercise programs can improve children's cognitive performance. In particular, little is known about the effects of small exercise programs that may be feasible in daily school practice. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372522PMC
February 2019

Effect of Acute Dietary Nitrate Supplementation on the Post-Exercise Ambulatory Blood Pressure in Obese Males: A Randomized, Controlled, Crossover Trial.

J Sports Sci Med 2019 Mar 11;18(1):118-127. Epub 2019 Feb 11.

Graduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.

This study aimed to verify the effect of beetroot juice on post-exercise ambulatory blood pressure (BP) in obese individuals. Fourteen non-hypertensive obese males were randomly assigned to three experimental sessions: 1) Beetroot juice with exercise (BJE, 200ml with ≈ 800mg nitrate and 40 minutes of moderate-intensity aerobic exercise at an intensity of 50% of the heart rate reserve), 2) fruit soda with exercise (FSE, 200ml of a low-nitrate drink and the same exercise session) and 3) control (CON, 200ml of water, an insignificant nitrate drink without exercise). The concentration of total nitrites and nitrates in plasma (NOx) after the drinks and the 24-hour ambulatory BP were evaluated. Read More

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Genome-wide association study of germline variants and breast cancer-specific mortality.

Authors:
Maria Escala-Garcia Qi Guo Thilo Dörk Sander Canisius Renske Keeman Joe Dennis Jonathan Beesley Julie Lecarpentier Manjeet K Bolla Qin Wang Jean Abraham Irene L Andrulis Hoda Anton-Culver Volker Arndt Paul L Auer Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Leslie Bernstein Carl Blomqvist Bram Boeckx Stig E Bojesen Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Hermann Brenner Adam Brentnall Louise Brinton Per Broberg Ian W Brock Sara Y Brucker Barbara Burwinkel Carlos Caldas Trinidad Caldés Daniele Campa Federico Canzian Angel Carracedo Brian D Carter Jose E Castelao Jenny Chang-Claude Stephen J Chanock Georgia Chenevix-Trench Ting-Yuan David Cheng Suet-Feung Chin Christine L Clarke Emilie Cordina-Duverger Fergus J Couch David G Cox Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Janet A Dunn Alison M Dunning Lorraine Durcan Miriam Dwek Helena M Earl Arif B Ekici A Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D Gareth Evans Jonine Figueroa Dieter Flesch-Janys Henrik Flyger Marike Gabrielson Manuela Gago-Dominguez Eva Galle Susan M Gapstur Montserrat García-Closas José A García-Sáenz Mia M Gaudet Angela George Vassilios Georgoulias Graham G Giles Gord Glendon David E Goldgar Anna González-Neira Grethe I Grenaker Alnæs Mervi Grip Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Per Hall Ute Hamann Susan Hankinson Elaine F Harkness Patricia A Harrington Steven N Hart Jaana M Hartikainen Alexander Hein Peter Hillemanns Louise Hiller Bernd Holleczek Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Guanmengqian Huang Keith Humphreys David J Hunter Wolfgang Janni Esther M John Michael E Jones Arja Jukkola-Vuorinen Audrey Jung Rudolf Kaaks Maria Kabisch Katarzyna Kaczmarek Michael J Kerin Sofia Khan Elza Khusnutdinova Johanna I Kiiski Cari M Kitahara Julia A Knight Yon-Dschun Ko Linetta B Koppert Veli-Matti Kosma Peter Kraft Vessela N Kristensen Ute Krüger Tabea Kühl Diether Lambrechts Loic Le Marchand Eunjung Lee Flavio Lejbkowicz Lian Li Annika Lindblom Sara Lindström Martha Linet Jolanta Lissowska Wing-Yee Lo Sibylle Loibl Jan Lubiński Michael P Lux Robert J MacInnis Melanie Maierthaler Tom Maishman Enes Makalic Arto Mannermaa Mehdi Manoochehri Siranoush Manoukian Sara Margolin Maria Elena Martinez Dimitrios Mavroudis Catriona McLean Alfons Meindl Pooja Middha Nicola Miller Roger L Milne Fernando Moreno Anna Marie Mulligan Claire Mulot Rami Nassir Susan L Neuhausen William T Newman Sune F Nielsen Børge G Nordestgaard Aaron Norman Håkan Olsson Nick Orr V Shane Pankratz Tjoung-Won Park-Simon Jose I A Perez Clara Pérez-Barrios Paolo Peterlongo Christos Petridis Mila Pinchev Karoliona Prajzendanc Ross Prentice Nadege Presneau Darya Prokofieva Katri Pylkäs Brigitte Rack Paolo Radice Dhanya Ramachandran Gadi Rennert Hedy S Rennert Valerie Rhenius Atocha Romero Rebecca Roylance Emmanouil Saloustros Elinor J Sawyer Daniel F Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Fredrick Schumacher Lukas Schwentner Rodney J Scott Christopher Scott Caroline Seynaeve Mitul Shah Jacques Simard Ann Smeets Christof Sohn Melissa C Southey Anthony J Swerdlow Aline Talhouk Rulla M Tamimi William J Tapper Manuel R Teixeira Maria Tengström Mary Beth Terry Kathrin Thöne Rob A E M Tollenaar Ian Tomlinson Diana Torres Thérèse Truong Constance Turman Clare Turnbull Hans-Ulrich Ulmer Michael Untch Celine Vachon Christi J van Asperen Ans M W van den Ouweland Elke M van Veen Camilla Wendt Alice S Whittemore Walter Willett Robert Winqvist Alicja Wolk Xiaohong R Yang Yan Zhang Douglas F Easton Peter A Fasching Heli Nevanlinna Diana M Eccles Paul D P Pharoah Marjanka K Schmidt

Br J Cancer 2019 Feb 21. Epub 2019 Feb 21.

The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.

Background: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry.

Methods: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Read More

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http://dx.doi.org/10.1038/s41416-019-0393-xDOI Listing
February 2019

Connecting the Dots: Validation of Time in Range Metrics With Microvascular Outcomes.

Diabetes Care 2019 Mar;42(3):345-348

Department of Pediatrics, Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA

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http://dx.doi.org/10.2337/dci18-0040DOI Listing

Using vibrational ATR-FTIR spectroscopy with chemometrics to reveal faba CHO molecular spectral profile and CHO nutritional features in ruminant systems.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 16;214:269-276. Epub 2019 Feb 16.

College of Life Science and Engineering, Foshan University, China; The Branch Academy of Animal Science, Jilin Academy of Agricultural Science, China; Department of Animal Nutrition, Bangladesh Agricultural University, Bangladesh; Animal Nutrition Institute, Sichuan Agricultural University, China; Department of Animal and Poultry Science, College of Agriculture and Bioresources, University of Saskatchewan, Canada. Electronic address:

The non-invasive spectroscopic technique is capable to detect the biomolecular structure spectral features that are associated with biological, nutritional and biodegradation functions. However, to date, no research has been reported on alteration of bioactive compounds/carbohydrate traits on physiochemical and structure spectral characteristics in faba pulse seeds. The objective of this study was to use non-invasive ATR-FTIR spectroscopy with uni- and multivariate analyses to reveal faba [VLF: VLF-1 = CDC snowdrop with low tannin and VLF-2 = FB9-4 with high tannin] CHO molecular spectral profile and CHO nutritional features in ruminant systems. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.011DOI Listing
February 2019

Dietary intake of people with severe mental illness: systematic review and meta-analysis.

Br J Psychiatry 2019 Feb 20:1-9. Epub 2019 Feb 20.

Associate Professor in Nutrition and Dietetics,School of Health Sciences and Priority Research Centre for Physical Activity and Nutrition,University of Newcastle,Australia.

Background: Severe mental illness (SMI) is thought to be associated with lower diet quality and adverse eating behaviours contributing towards physical health disparities. A rigorous review of the studies looking at dietary intake in psychotic disorders and bipolar disorder is lacking.AimsTo conduct a systematic, comprehensive evaluation of the published research on dietary intake in psychotic disorders and bipolar disorder. Read More

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http://dx.doi.org/10.1192/bjp.2019.20DOI Listing
February 2019

Comparative analysis of the influence of a high-fat/high-carbohydrate diet on the level of anxiety and neuromotor and cognitive functions in Wistar and DAT-KO rats.

Physiol Rep 2019 Feb;7(4):e13987

Federal Research Centre of Nutrition and Biotechnology, Moscow, Russia.

We compared anxiety, neuromotor, and cognitive functions in mutant rats with different allelic variants of dopamine transporter DAT knockout receiving balanced or excess in fat and fructose diet. The experiments were performed in DAT-/- homozygotes, DAT+/- heterozygotes, and DAT+/+ wild type rats. The genotype of DAT-KO rats was confirmed by restriction analysis of DAT gene compared to behavioral responses in the open field test (OF). Read More

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http://dx.doi.org/10.14814/phy2.13987DOI Listing
February 2019

Protective effects of fermented goat milk on genomic stability, oxidative stress and inflammatory signalling in testis during anaemia recovery.

Sci Rep 2019 Feb 19;9(1):2232. Epub 2019 Feb 19.

Department of Physiology, University of Granada, Granada, Spain.

Oxidative stress is a harmful factor for male reproductive function, and a major cause of infertility. On the other hand, fermented goat milk has positive effects on anemia recovery and mineral metabolism. This study evaluated the effect of feeding rats with fermented milks during anaemia recovery on molecular mechanisms linked to oxidative stress and inflammatory signalling in rats reproductive system. Read More

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http://dx.doi.org/10.1038/s41598-018-37649-6DOI Listing
February 2019

Selective citation in the literature on the hygiene hypothesis: a citation analysis on the association between infections and rhinitis.

BMJ Open 2019 Feb 19;9(2):e026518. Epub 2019 Feb 19.

Nutrition and Translational Research in Metabolism (School NUTRIM), Maastricht University, Maastricht, Limburg, The Netherlands.

Objective: Our objective was to assess the occurrence and determinants of selective citation in scientific publications on Strachan's original hygiene hypothesis. His hypothesis states that lack of exposure to infections in early childhood increases the risk of rhinitis.

Setting: Web of Science Core Collection. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026518DOI Listing
February 2019

Multigenerational metabolic profiling in the Michigan PBB registry.

Environ Res 2019 Feb 13;172:182-193. Epub 2019 Feb 13.

Department of Civil and Environmental Engineering, Tufts University, 200 College Ave, Medford MA 02155, United States. Electronic address:

Although polychlorinated biphenyls and polybrominated biphenyls are no longer manufactured the United States, biomonitoring in human populations show that exposure to these pollutants persist in human tissues. The objective of this study was to identify metabolic variations associated with exposure to 2,2'4,4',5,5'-hexabromobiphenyl (PBB-153) and 2,2'4,4',5,5'-hexachlorobiphenyl (PCB-153) in two generations of participants enrolled in the Michigan PBB Registry (http://pbbregistry.emory. Read More

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http://dx.doi.org/10.1016/j.envres.2019.02.018DOI Listing
February 2019

Dietary fish oil supplementation alters liver gene expressions to protect against LPS-induced liver injury in weanling piglets.

Innate Immun 2019 Jan;25(1):60-72

Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan, China.

Here, the potential mechanisms of the protective effects of fish oil against LPS-induced liver injury in a piglet model were investigated by using RNA sequencing. Twenty-four piglets were used in a 2 × 2 factorial design, and the main factors included diet (5% corn oil or 5% fish oil) and immunological challenge (LPS or saline, on d 19). All piglets were slaughtered at 4 h after challenge, and liver samples were collected. Read More

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http://dx.doi.org/10.1177/1753425918821420DOI Listing
January 2019

Thermogenesis-based interventions for obesity and Type 2 diabetes mellitus.

Expert Rev Endocrinol Metab 2013 May;8(3):275-288

a Department of Medicine, Endocrinology, Metabolism & Nutrition, UMDNJ-RWJMS, New Brunswick, NJ 08903, USA.

Obesity is one of the key noncommunicable diseases leading to significant comorbidities. In recent years, obesity has become a major public health issue and has threatened the wellbeing of millions of patients. Although there are multiple reasons for people becoming obese, sustained positive energy balance - energy intake is greater than energy expenditure - is the key for accumulating excess bodyfat. Read More

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http://dx.doi.org/10.1586/eem.13.13DOI Listing

IMPROVE™ observational study of biphasic insulin aspart 30/70 in patients with Type 2 diabetes mellitus.

Expert Rev Endocrinol Metab 2010 Jul;5(4):507-516

b Department of Endocrinology Diabetology Nutrition, Paris Nord University, AP-HP, Jean Verdier Hospital, CRNH-IdF, Bondy, France.

The IMPROVE™ study is the largest observational study of therapy in Type 2 diabetes mellitus to date. It is a multinational study investigating the safety and efficacy of biphasic insulin aspart 30/70 (BIAsp 30) in the routine management of patients with Type 2 diabetes mellitus. Five published reports on this study have provided baseline demographic information for patients receiving BIAsp 30 in eight countries, information on the safety and efficacy outcomes for those patients and analyses of three subgroups of patients who were insulin-naive, receiving basal insulin or receiving biphasic human insulin before the start of the study. Read More

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http://dx.doi.org/10.1586/eem.10.31DOI Listing

Shedding Light on Vitamin D Status and Its Complexities during Pregnancy, Infancy and Childhood: An Australian Perspective.

Int J Environ Res Public Health 2019 Feb 13;16(4). Epub 2019 Feb 13.

Women's and Children's Division, Sunshine Hospital, St Albans, VIC 3021, Australia.

Ensuring that the entire Australian population is Vitamin D sufficient is challenging, given the wide range of latitudes spanned by the country, its multicultural population and highly urbanised lifestyle of the majority of its population. Specific issues related to the unique aspects of vitamin D metabolism during pregnancy and infancy further complicate how best to develop a universally safe and effective public health policy to ensure vitamin D adequacy for all. Furthermore, as Australia is considered a "sunny country", it does not yet have a national vitamin D food supplementation policy. Read More

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http://dx.doi.org/10.3390/ijerph16040538DOI Listing
February 2019

Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease.

Diseases 2019 Feb 13;7(1). Epub 2019 Feb 13.

Division of Nephrology, Department of Medicine, University of California-Irvine, Irvine, CA 92697, USA.

Chronic kidney disease (CKD) is a worldwide major health problem. Traditional risk factors for CKD are hypertension, obesity, and diabetes mellitus. Recent studies have identified gut dysbiosis as a novel risk factor for the progression CKD and its complications. Read More

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http://dx.doi.org/10.3390/diseases7010021DOI Listing
February 2019

Identification of Differentially Expressed Genes and Pathways for Abdominal Fat Deposition in Ovariectomized and Sham-Operated Chickens.

Genes (Basel) 2019 Feb 18;10(2). Epub 2019 Feb 18.

Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Ovariectomy results in improved meat quality (growth rate, tenderness, and flavor) of broilers. However, some negative effects increased (abdominal fat (AF) deposition, low feed conversion, etc.) have also been reported. Read More

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http://dx.doi.org/10.3390/genes10020155DOI Listing
February 2019

The Obemat2.0 Study: A Clinical Trial of a Motivational Intervention for Childhood Obesity Treatment.

Nutrients 2019 Feb 16;11(2). Epub 2019 Feb 16.

Pediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, IISPV, 43201 Reus, Spain.

The primary aim of the Obemat2.0 trial was to evaluate the efficacy of a multicomponent motivational program for the treatment of childhood obesity, coordinated between primary care and hospital specialized services, compared to the usual intervention performed in primary care. This was a cluster randomized clinical trial conducted in Spain, with two intervention arms: motivational intervention group vs. Read More

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http://www.mdpi.com/2072-6643/11/2/419
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http://dx.doi.org/10.3390/nu11020419DOI Listing
February 2019
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The Association between Plasma Omega-6/Omega-3 Ratio and Anthropometric Traits Differs by Racial/Ethnic Groups and Genotypes in Healthy Young Adults.

J Pers Med 2019 Feb 16;9(1). Epub 2019 Feb 16.

School of Nutrition Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Evidence for a relationship between omega-6/omega-3 (n-6/n-3) polyunsaturated fatty acid (PUFA) ratio and obesity in humans is inconsistent, perhaps due to differences in dietary intake or metabolism of PUFAs between different subsets of the population. Since chronic inflammation is central to obesity and inflammatory pathways are regulated by PUFAs, the objective of this study was to examine whether variants in the gene, an upstream regulator of the inflammatory response, modify the association between the n-6/n-3 ratio (from diet and plasma) and anthropometric traits in a multiethnic/multiracial population of young adults. Participants' ( = 898) dietary PUFA intake was assessed using a food frequency questionnaire and plasma PUFA concentrations by gas chromatography. Read More

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http://dx.doi.org/10.3390/jpm9010013DOI Listing
February 2019

Impact of a Usual Serving Size of Flavanol-Rich Cocoa Powder Ingested with a Diabetic-Suitable Meal on Postprandial Cardiometabolic Parameters in Type 2 Diabetics-A Randomized, Placebo-Controlled, Double-Blind Crossover Study.

Nutrients 2019 Feb 16;11(2). Epub 2019 Feb 16.

Faculty of Food, Nutrition and Hospitality Sciences, Hochschule Niederrhein, University of Applied Sciences, Rheydter Str. 277, 41065 Mönchengladbach, Germany.

Randomized controlled trials indicate that flavanol-rich cocoa intake may improve postprandial glucose and lipid metabolism in patients with type 2 diabetes (T2D), based on studies with meals that impose a strong metabolic load. Hence, the aim of the present study was to investigate whether flavanol-rich cocoa powder ingested as part of a diabetic-suitable meal may beneficially affect glucose, lipid metabolism, and blood pressure (BP) in patients with T2D. Twelve adults with T2D, overweight/obesity, and hypertension ingested capsules with 2. Read More

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http://dx.doi.org/10.3390/nu11020417DOI Listing
February 2019

Trustworthiness of randomized trials in endocrinology-A systematic survey.

PLoS One 2019 19;14(2):e0212360. Epub 2019 Feb 19.

Endocrinology Division, Department of Internal Medicine, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, México.

Background: Trustworthy (i.e. low risk of bias) randomized clinical trials (RCTs) play an important role in evidence-based decision making. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212360PLOS
February 2019

Metabolic response to drought in six winter wheat genotypes.

PLoS One 2019 19;14(2):e0212411. Epub 2019 Feb 19.

Department of Plant Physiology, Agricultural Institute, Centre for Agricultural Research of the Hungarian Academy of Sciences, Martonvásár, Hungary.

Wheat is one of the most important cereals, whose growth and development is strongly limited by drought. This study investigated the physiological and metabolic response of six winter wheat cultivars to drought with the emphasis on the induction of dominant metabolites affected by the treatment and genotypes or both. The plants were exposed to a moderate (non-lethal) drought stress, which was induced by withholding watering for six days under controlled greenhouse conditions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212411PLOS
February 2019