452,901 results match your criteria Nutrition & Metabolism[Journal]


APOC3 promotes TNF-α-induced expression of JAM-1 in endothelial cell via PI3K-IKK2-p65 pathway.

Cardiovasc Pathol 2019 Mar 4;41:11-17. Epub 2019 Mar 4.

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, 20 Xi Si Road, Nantong 226001, People's Republic of China; Insitute of Public Health, Nantong University, 9 Se Yuan Road, Nantong 226001, People's Republic of China. Electronic address:

Atherosclerosis is a chronic inflammatory disease with lipid accumulation. Apolipoprotein C3 (APOC3), which is an important regulator of human lipid metabolism, is associated with multiple vascular mechanisms in atherosclerosis and proinflammatory responses. We have previously reported that the expression of inflammatory cytokine TNF-α is elevated in human endothelial cells (HUVECs) after APOC3 treatment. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.02.005DOI Listing

Microelements in seminal and serum plasma are associated with fresh semen quality in Yorkshire boars.

Theriogenology 2019 Apr 6;132:88-94. Epub 2019 Apr 6.

Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, PR China. Electronic address:

This study aimed to explore associations between semen quality and trace element level in serum and seminal plasma in Yorkshire boars. Semen quality of 112 Yorkshire boars was assessed for 13 weeks to calculate semen utilization rate, which was then divided into three categories: low utilization rate group (LG, < 60% utilization rate), medium utilization rate group (MG, 60-80%), and high utilization rate group (HG, > 80%). After grouping, serum and seminal plasma samples of selected boars were collected to determine concentrations of 10 elements including Ca, Mg, Cu, Fe, Zn, Mn, Se, Cr, Pb and Cd using inductively coupled plasma mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.04.002DOI Listing

Extent and Determinants of Terminally Ill Cancer Patients' Concordance between Preferred and Received Life-Sustaining Treatment States: An Advance Care Planning Randomized Trial in Taiwan.

J Pain Symptom Manage 2019 Apr 17. Epub 2019 Apr 17.

Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taiwan; Department of Nursing, Chang Gung Memorial Hospital at Kaohsiung, Taiwan. Electronic address:

Purpose: To examine the effectiveness of an advance care planning (ACP) intervention in facilitating concordance between cancer patients' preferred and received life-sustaining treatment (LST) states and to explore modifiable factors facilitating or impeding such concordance.

Methods: Terminal cancer patients (N=460) were randomly assigned 1:1 to the experimental and control arms of a randomized clinical trial, with 430 deceased participants comprising the final sample. States of preferred LSTs (cardiopulmonary resuscitation, intensive care unit care, chest compression, intubation with mechanical ventilation, intravenous nutrition, and nasogastric tube feeding) and LSTs received in the last month were examined by hidden Markov modeling. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.04.010DOI Listing
April 2019
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Letter to The Editor - Referring to the published article - Topical Steroids Alters Disease Course Over a 5-Year Follow-up Period in Adult Patients.

Authors:
Noam Zevit

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Institute of Gastroenterology, Nutrition, and Liver Diseases; Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.04.028DOI Listing

Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions.

Biotechnol Adv 2019 Apr 17. Epub 2019 Apr 17.

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau. Electronic address:

The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.007DOI Listing

Strength of association between pentosan polysulfate and a novel maculopathy.

Ophthalmology 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322. Electronic address:

In this retrospective study of 219 patients with interstitial cystitis at a single institution, pentosan polysulfate exposure was the sole predictor of a newly described maculopathy. All 14 affected patients had exposure to the drug. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.04.024DOI Listing

Monosaccharide composition influence and immunomodulatory effects of probiotic exopolysaccharides.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Department of Food Science and Nutrition, Meiho University, Taiwan. Electronic address:

Exopolysaccharides (EPSs) are metabolites of probiotics that have gained wide interest recently. A strain of Lactobacillus reuteri Mh-001 with high exopolysaccharide (EPS) production ability was isolated, identified, and were used to investigate the anti-inflammatory effects of the EPSs. Among the three unpurified EPSs, RAW246. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.109DOI Listing

Maternal Triacylglycerol Signature and Offspring Risk of Food Allergy.

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA; Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Background: The prevalence of IgE-mediated food allergy (FA) is rising worldwide but the underlying mechanisms are poorly understood.

Objective: To examine the role of maternal lipidomic profiles in offspring risk of FA development; and to investigate the potential modification effects by timing of first solid food introduction.

Methods: This report included 1,068 mother-child dyads from the Boston Birth Cohort. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.03.033DOI Listing

Ferric citrate, nitrate, saponin, and their combinations affect in-vitro ruminal fermentation, production of sulfide and methane, and abundance of select microbial populations.

J Appl Microbiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Animal Sciences, The Ohio State University, Columbus, Ohio, 43210-1094, USA.

Aims: This study investigated the effects of ferric citrate, nitrate, and saponin, both individually and in combination, on sulfidogenesis, methanogenesis, rumen fermentation, and abundances of select microbial populations using in vitro rumen cultures.

Methods And Results: Ferric citrate (50 mg L ), Quillaja saponin (0·6 g L ), and sodium nitrate (5 mmol L ) were used in in vitro ruminal fermentation. Ferric citrate alone, its combination with saponin and/or nitrate lowered the aqueous sulfide concentration and total sulfide production. Read More

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http://dx.doi.org/10.1111/jam.14286DOI Listing

Qualitative analysis of the vocabulary used in work logs of a preventive program for elderly oral function and nutrition.

J Oral Rehabil 2019 Apr 20. Epub 2019 Apr 20.

Oral Rehabilitation, Niigata University Medical and Dental Hospital.

Background: In Japan, daycare services for elders include programs aimed at improving nutrition and oral and motor functions. Few studies have qualitatively assessed these interventions.

Objective: To qualitatively search for the characteristic words used in the work logs of a preventive program on oral function and nutrition for elders by intervention period and intervention type. Read More

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http://dx.doi.org/10.1111/joor.12804DOI Listing

Nisin incorporation enhances the inactivation of lactic acid bacteria during the acid wash step of bioethanol production from sugarcane juice.

Lett Appl Microbiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Food Science & Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Bioethanol fermentation is continuously exposed to contamination by Lactic Acid Bacteria (LAB). In the present study, the effect of adding nisin (250 mg L ) to the acid wash on the viability of five bacterial contaminants were evaluated both alone and in co-incubation with Saccharomyces cerevisiae. Additionally, fed-batch fermentation was performed using an acid or acid/nisin wash for S. Read More

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http://dx.doi.org/10.1111/lam.13165DOI Listing

Spinal cord-level adaptations to resistance training: the 'backbone' of early strength gains?

J Physiol 2019 Apr 20. Epub 2019 Apr 20.

Institute of Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC, 3125.

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http://dx.doi.org/10.1113/JP277893DOI Listing
April 2019
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Validity of Digital and Manual Refractometers for Measuring Urine Specific Gravity During Field Operations: A Brief Report.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Military Nutrition Division, US Army Research Institute of Environmental Medicine, 10 General Greene Ave., Natick, MA 01760.

Introduction: Dehydration can have an immediate negative impact on the performance of Soldiers in training or combat environments. Field expedient methods for assessing hydration status may be valuable for service members. Measurement of urine-specific gravity (USG) via refractometer is inexpensive, simple, fast, and a validated indicator of hydration status. Read More

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http://dx.doi.org/10.1093/milmed/usz082DOI Listing

Role of Leptin in the Association Between Body Adiposity and Persistent Asthma: A Longitudinal Study.

Obesity (Silver Spring) 2019 Apr 20. Epub 2019 Apr 20.

VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, INSERM U1168, Villejuif, France.

Objective: Obesity is a likely risk factor for asthma. However, underlying mechanisms by which obesity affects asthma activity remain poorly understood. This study aimed to investigate the role of leptin, an adipocyte-derived proinflammatory protein, as a mediator in the association between body adiposity (assessed using BMI, waist circumference, and body fat percentage) and persistent asthma. Read More

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http://dx.doi.org/10.1002/oby.22466DOI Listing

Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans.

Obesity (Silver Spring) 2019 Apr 19. Epub 2019 Apr 19.

Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA.

Objective: Connective tissue growth factor (CTGF) is an important regulator of fibrogenesis in many organs. This study evaluated the interrelationship among adipose tissue CTGF expression, fat mass, and insulin resistance in humans.

Methods: This study examined (1) CTGF gene expression in human subcutaneous preadipocytes before and after inducing adipogenesis; (2) relationships among abdominal subcutaneous adipose tissue CTGF gene expression, body fat mass, and indices of insulin sensitivity, including the hepatic insulin sensitivity index and the hyperinsulinemic-euglycemic clamp procedure in conjunction with stable isotope glucose tracer infusion, in 72 people who had marked differences in adiposity and insulin sensitivity; (3) localization of CTGF protein in subcutaneous adipose tissue; and (4) effect of progressive (5%, 11%, and 16%) weight loss on adipose tissue CTGF gene expression. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.22463
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http://dx.doi.org/10.1002/oby.22463DOI Listing
April 2019
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Physiological Predictors of Weight Regain at 1-Year Follow-Up in Weight-Reduced Adults with Obesity.

Obesity (Silver Spring) 2019 Apr 20. Epub 2019 Apr 20.

Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Objective: This study aimed to assess whether changes in resting metabolic rate (RMR), exercise-induced energy expenditure (EIEE), and appetite following weight loss (WL) are associated with weight regain at 1 year.

Methods: Thirty-six adults with obesity underwent 8 weeks of a very-low-energy diet, followed by 4 weeks of refeeding and a 1-year maintenance program. RMR, EIEE, appetite ratings, and active ghrelin, peptide YY, glucagon-like peptide-1, cholecystokinin, and insulin concentrations were measured at baseline, week 13, and 1 year. Read More

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http://dx.doi.org/10.1002/oby.22476DOI Listing

Metabolic Risk Factors Associated with Visceral and Subcutaneous Adipose Tissue in a Sex-Specific Manner in Seven-Year-Olds.

Obesity (Silver Spring) 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objective: This study aimed to investigate how visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes were associated with metabolic risk factors in 7-year-old children.

Methods: A total of 81 children (52% girls) from a Swedish birth cohort were studied. At 6 years of age, anthropometric data, fasting insulin, glucose, cholesterol, and blood pressure were collected on 53 children with normal weight and 28 children with overweight or obesity, and insulin resistance was estimated. Read More

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http://dx.doi.org/10.1002/oby.22453DOI Listing

The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Endometriosis is a frequent and chronic illness in young women which could be defined by the existence of endometrial stroma and glands outside of the normal site of the lining of the uterus. It has painful symptoms. The advanced stage of endometriosis may lead to gynecological malignancies, such as ovarian cancer, and other complications, including infertility. Read More

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http://dx.doi.org/10.1002/jcp.28666DOI Listing

Overweight in family members of probands with ADHD.

Eur Child Adolesc Psychiatry 2019 Apr 19. Epub 2019 Apr 19.

Karakter Child and Adolescent Psychiatry University Center, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.

The widely reported association between ADHD and overweight may be attributable to genetic and environmental factors also present in unaffected family members. Therefore, the purpose of this study was to examine the association between ADHD and overweight within families. A cohort was used of families with at least one member with ADHD, recruited as part of the Dutch node of the International Multicenter ADHD Genetics (IMAGE) study, with assessments taking place between 2003 and 2006, 2009 and 2012, and 2013 and 2015. Read More

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http://link.springer.com/10.1007/s00787-019-01331-7
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http://dx.doi.org/10.1007/s00787-019-01331-7DOI Listing
April 2019
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Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice.

J Nutr 2019 Apr 20. Epub 2019 Apr 20.

Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China.

Background: Short-chain fatty acids (SCFAs) have been reported to ameliorate obesity. However, the underlying mechanisms require further investigation.

Objective: The aim of this study was to determine the role of butyrate, an SCFA, in the regulation of obesity, low-grade chronic inflammation, and alterations of microbiota composition in mice. Read More

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http://dx.doi.org/10.1093/jn/nxy324DOI Listing

Long-Term Change in both Dietary Insulinemic and Inflammatory Potential Is Associated with Weight Gain in Adult Women and Men.

J Nutr 2019 Apr 20. Epub 2019 Apr 20.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Background: The influence of long-term dietary patterns on weight gain and the underlying potential biological mechanisms are not fully understood.

Objective: We prospectively examined the association of changes in 2 empirical hypothesis-oriented dietary patterns (insulinemic and inflammatory) and weight gain over 24 y at 4-y intervals.

Methods: We followed 54,397 women in the Nurses' Health Study and 33,043 men in the Health Professionals Follow-Up Study (1986-2010), and computed the empirical dietary index for hyperinsulinemia (EDIH) and empirical dietary inflammatory pattern (EDIP) scores from food frequency questionnaires administered every 4 y. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxy319DOI Listing
April 2019
1 Read

Lower carbohydrate diets and all-cause and cause-specific mortality: a population-based cohort study and pooling of prospective studies.

Eur Heart J 2019 Apr 19. Epub 2019 Apr 19.

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland.

Aims: Little is known about the long-term association between low-carbohydrate diets (LCDs) and mortality. We evaluated the link between LCD and overall or cause-specific mortality using both individual data and pooled prospective studies.

Methods And Results: Data on diets from the National Health and Nutrition Examination Survey (NHANES; 1999-2010) were analysed. Read More

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https://academic.oup.com/eurheartj/advance-article/doi/10.10
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http://dx.doi.org/10.1093/eurheartj/ehz174DOI Listing
April 2019
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Integration of the UNICEF nutrition supply chain: a cost analysis in Kenya.

Health Policy Plan 2019 Apr 19. Epub 2019 Apr 19.

UNICEF Eastern and Southern Africa Regional Office, United Nations Complex Gigiri, United Nations Avenue, Nairobi, Kenya.

Integration of parallel health commodities supply chains into one national supply chain is becoming more common globally as national health systems are strengthened and organizations realize the potential for increased effectiveness and cost reduction from integration. UNICEF conducted a 10-week pilot to integrate its supply chain for nutrition commodities into the national Ministry of Health supply chain for medical commodities. This paper is a cost analysis of the integration process in two counties, comparing four scenarios of cost structures before, during and after integration. Read More

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http://dx.doi.org/10.1093/heapol/czz007DOI Listing

The Kansas University DHA Outcomes Study (KUDOS) clinical trial: long-term behavioral follow-up of the effects of prenatal DHA supplementation.

Am J Clin Nutr 2019 Apr 20. Epub 2019 Apr 20.

Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS.

Background: Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid that has been linked to improved vision and cognition in postnatal feeding studies and has been consistently associated with reduction of early preterm birth in prenatal supplementation trials. This is a report of the first long-term follow-up of infants from mothers receiving prenatal DHA supplementation in a US cohort.

Objective: Our objective was to evaluate the efficacy of the prenatal supplementation on both global and granular longitudinal assessments of cognitive and behavioral development. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqz018DOI Listing
April 2019
1 Read

Consumption of Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate: A Stable Iron Isotope Study in Iron-Depleted Young Women.

J Nutr 2019 Apr 20. Epub 2019 Apr 20.

Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.

Background: Animal studies suggest prebiotics can increase iron absorption, but results from human studies are equivocal.

Objectives: In iron-depleted women, before (baseline) and after daily consumption of galacto-oligosaccharides (GOS) for 4 wk, we sought to assess fractional iron absorption (FIA) from an iron supplement given with and without single doses of GOS in test meals or water.

Methods: In all women (n = 34; median serum ferritin concentration = 16. Read More

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http://dx.doi.org/10.1093/jn/nxy327DOI Listing

High Bioavailability from Ferric Pyrophosphate-Fortified Bouillon Cubes in Meals is Not Increased by Sodium Pyrophosphate: a Stable Iron Isotope Study in Young Nigerian Women.

J Nutr 2019 Apr 20. Epub 2019 Apr 20.

Unilever R&D Vlaardingen, South Holland, The Netherlands.

Background: It is challenging to find an iron compound that combines good bioavailability with minimal sensory changes when added to seasonings or condiments. Ferric pyrophosphate (FePP) is currently used to fortify bouillon cubes, but its bioavailability is generally low. Previously, the addition of a stabilizer, sodium pyrophosphate (NaPP), improved iron bioavailability from a bouillon drink. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxz003DOI Listing
April 2019
1 Read

Impact of water quality, sanitation, handwashing, and nutritional interventions on enteric infections in rural Zimbabwe: the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial.

J Infect Dis 2019 Apr 20. Epub 2019 Apr 20.

Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, VA, USA.

Background: We assessed the impact of water, sanitation, and hygiene (WASH) and infant and young child feeding (IYCF) interventions on enteric infections in the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe.

Methods: We tested stool samples collected at 1, 3, 6, and 12 months of age and during diarrhea using quantitative molecular diagnostics for 29 pathogens. We estimated the effects of the WASH, IYCF, and combined WASH+IYCF on individual enteropathogen prevalence and quantity, total numbers of pathogens detected, and incidence of pathogen-attributable diarrhea. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz179DOI Listing
April 2019
1 Read

Zinc Absorption From Agronomically Biofortified Wheat Is Similar to Post-Harvest Fortified Wheat and Is a Substantial Source of Bioavailable Zinc in Humans.

J Nutr 2019 Apr 20. Epub 2019 Apr 20.

Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.

Background: Limited data exist on human zinc absorption from wheat biofortified via foliar (FBW) or root (hydroponically fortified wheat, HBW) zinc application. Stable isotope labels added at point of consumption (extrinsic labeling) might not reflect absorption from native zinc obtained by intrinsic labeling.

Objectives: We measured fractional and total zinc absorption (FAZ, TAZ) in FBW and HBW wheat, compared with control wheat (CW) and fortified wheat (FW). Read More

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http://dx.doi.org/10.1093/jn/nxy328DOI Listing

Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis.

Gut 2019 Apr 19. Epub 2019 Apr 19.

Centre de Recherche Saint-Antoine (CRSA), Sorbonne Université, INSERM, Paris, France.

Objective: Patients with primary sclerosing cholangitis (PSC) were previously shown to display a bacterial gut dysbiosis but fungal microbiota has never been examined in these patients. The aim of this study was to assess the fungal gut microbiota in patients with PSC.

Design: We analysed the faecal microbiota of patients with PSC and concomitant IBD (n=27), patients with PSC and no IBD (n=22), patients with IBD and no PSC (n=33) and healthy subjects (n=30). Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317791DOI Listing

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging.

Mol Metab 2019 Apr 4. Epub 2019 Apr 4.

Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München, Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Nuthetal, Germany. Electronic address:

Objective: Aging is accompanied by loss of brown adipocytes and a decline in their thermogenic potential, which may exacerbate the development of adiposity and other metabolic disorders. Presently, only limited evidence exists describing the molecular alterations leading to impaired brown adipogenesis with aging and the contribution of these processes to changes of systemic energy metabolism.

Methods: Samples of young and aged murine brown and white adipose tissue were used to compare age-related changes of brown adipogenic gene expression and thermogenesis-related lipid mobilization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183119
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http://dx.doi.org/10.1016/j.molmet.2019.03.011DOI Listing
April 2019
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Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.

Mol Metab 2019 Apr 5. Epub 2019 Apr 5.

DKFZ Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany. Electronic address:

Objective: The susceptibility to abdominal obesity and the metabolic syndrome is determined to a substantial extent during childhood and adolescence, when key adipose tissue characteristics are established. Although the general impact of postnatal nutrition is well known, it is not clear how specific dietary components drive adipose tissue growth and how this relates to the risk of metabolic dysfunction in adulthood.

Methods: Adipose tissue growth including cell proliferation was analyzed in juvenile mice upon dietary manipulation with in vivo nucleotide labeling. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.03.012DOI Listing

Distinct phospholipid and sphingolipid species are linked to altered HDL function in apolipoprotein A-I deficiency.

J Clin Lipidol 2019 Feb 25. Epub 2019 Feb 25.

UMR-ICAN 1166, National Institute for Health and Medical Research (INSERM), Sorbonne University, Paris, France. Electronic address:

Background: Familial apolipoprotein A-I (apoA-I) deficiency (FAID) involving low levels of both apoA-I and high-density lipoprotein (HDL) cholesterol is associated with accelerated atherosclerosis.

Objective: The objective of this study was to define distinctive patterns in the lipidome of HDL subpopulations in FAID in relationship to antiatherogenic activities.

Methods: Five HDL subfractions were isolated by ultracentrifugation from plasma of FAID Caucasian patients (n = 5) and age-matched healthy normolipidemic Caucasian controls (n = 8), and the HDL lipidome (160 molecular species of 9 classes of phospholipids and sphingolipids) was quantitatively evaluated. Read More

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http://dx.doi.org/10.1016/j.jacl.2019.02.004DOI Listing
February 2019

Associations Between Intuitive Eating Behaviors and Fruit and Vegetable Intake Among College Students.

J Nutr Educ Behav 2019 Apr 17. Epub 2019 Apr 17.

Food Science and Human Nutrition Department, University of Florida, Gainesville, FL. Electronic address:

Objective: To assess associations between intuitive eating behaviors and fruit and vegetable intake among college students.

Methods: Intuitive eating behaviors were measured with the Intuitive Eating Scale-2 (IES-2), which reports a total and 4 subscale scores. Fruit and vegetable intake was measured with the National Institutes of Health Eating at America's Table Fruit and Vegetable screener. Read More

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http://dx.doi.org/10.1016/j.jneb.2019.03.010DOI Listing

Circulating adipokines and risk of obesity related cancers: A systematic review and meta-analysis.

Obes Res Clin Pract 2019 Apr 16. Epub 2019 Apr 16.

Department of Family Medicine, Center for Obesity, Metabolism and Nutrition, Dongguk University Ilsan Hospital, 27 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, South Korea. Electronic address:

Background: Obesity can influence on carcinogenesis through alterations in adipokines and subsequent inflammatory changes. This meta-analysis was aimed to comprehensively assess the association between circulating adipokines and risk of obesity-related cancers.

Methods: Pubmed and Embase were searched up to October 2017 for observational studies investigating the relationship between adipokines and cancers. Read More

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http://dx.doi.org/10.1016/j.orcp.2019.03.006DOI Listing
April 2019
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The impact of sex on risk of cardiovascular disease and all-cause mortality in adults with or without diabetes mellitus: A comparison between the U.S. and Japan.

J Diabetes Complications 2019 Apr 1. Epub 2019 Apr 1.

Department of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Shiga, Japan.

Aims: To test a hypothesis that women with diabetes mellitus (DM) versus those without DM had a significantly higher risk of heart disease (HD), stroke and all-cause mortality than their male counterparts in the U.S. as well as in Japan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183131
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http://dx.doi.org/10.1016/j.jdiacomp.2019.03.008DOI Listing
April 2019
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CRISPR-Directed Microbiome Manipulation across the Food Supply Chain.

Trends Microbiol 2019 Apr 16. Epub 2019 Apr 16.

Food Microbiology, Wageningen University and Research, Wageningen, The Netherlands. Electronic address:

The advent of CRISPR-based technologies has revolutionized genetics over the past decade, and genome editing is now widely implemented for diverse medical and agricultural applications, such as correcting genetic disorders and improving crop and livestock breeding. CRISPR-based technologies are also of great potential to alter the genetic content of food bacteria in order to control the composition and activity of microbial populations across the food supply chain, from the farm to consumer products. Advancing the food supply chain is of great societal importance as it involves optimizing fermentation processes to enhance taste and sensory properties of food products, as well as improving food quality and safety by controlling spoilage bacteria and pathogens. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0966842X193007
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http://dx.doi.org/10.1016/j.tim.2019.03.006DOI Listing
April 2019
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SEEN guidelines for the management and prevention of acute adrenal insufficiency.

Endocrinol Diabetes Nutr 2019 Apr 16. Epub 2019 Apr 16.

Servicio de Endocrinología y Nutrición, Hospital Clínico, Barcelona, España. Electronic address:

Acute adrenal insufficiency (AAI) is a potentially fatal medical emergency whose prevention and treatment should be known by all medical professionals. AAI is an underdiagnosed condition because of its non-specific symptoms, but its diagnosis and early treatment with glucocorticoids is vital. It may be triggered by a de novo deficiency in cortisol synthesis or occur secondarily to omission of hormone replacement therapy (corticosteroids) or inadequate adjustment of the dose required in stress situations in patients previously diagnosed with adrenal insufficiency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164193003
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http://dx.doi.org/10.1016/j.endinu.2019.01.004DOI Listing
April 2019
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The aggregate income losses from childhood stunting and the returns to a nutrition intervention aimed at reducing stunting.

Econ Hum Biol 2019 Mar 18. Epub 2019 Mar 18.

Development Research Group, The World Bank. Addressfor correspondence: Emanuela Galasso, The World Bank, 1818 H St, NW, MSN MC3-306, Washington DC, 20433, USA.

We undertake two calculations, one for all developing countries, the other for 34 developing countries that together account for 90% of the world's stunted children. The first asks how much lower a country's per capita income is today as a result of having a fraction of its workforce been stunted in childhood. We use a development accounting framework, relying on micro-econometric estimates of the effects of childhood stunting on adult wages through their effects on years of schooling, cognitive skills, and height, parsing out the relative contribution of each set of returns to avoid double counting. Read More

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http://dx.doi.org/10.1016/j.ehb.2019.01.010DOI Listing

Dietary Approaches to Stop Hypertension Diet Concordance and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis.

Am J Prev Med 2019 Apr 16. Epub 2019 Apr 16.

Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Introduction: In observational studies, the association between the Dietary Approaches to Stop Hypertension (DASH) diet and incident heart failure has been inconsistent. It was hypothesized that higher DASH diet concordance has a protective effect on heart failure in a multi-ethnic cohort.

Methods: The Multi-Ethnic Study of Atherosclerosis cohort includes men and women of multiple ethnicities who were aged 45-84 years and free of clinical cardiovascular disease at baseline. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797183244
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http://dx.doi.org/10.1016/j.amepre.2018.11.022DOI Listing
April 2019
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Prevalence and Correlates of Receiving Medical Advice to Increase Physical Activity in U.S. Adults: National Health and Nutrition Examination Survey 2013-2016.

Am J Prev Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland; U.S. Public Health Service, Rockville, Maryland.

Introduction: National objectives recommend healthcare professionals provide physical activity advice. This study examined health and demographic characteristics associated with receipt of medical advice to increase physical activity among U.S. Read More

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http://dx.doi.org/10.1016/j.amepre.2019.01.003DOI Listing

The Supplemental Nutrition Assistance Program and Child Weight Status: A Review.

Am J Prev Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Public Health Sciences, University of North Carolina-Charlotte, Charlotte, North Carolina.

Context: The Supplemental Nutrition Assistance Program (SNAP) is a food assistance program that helps Americans afford a healthy diet. However, its influence on children's weight status is unclear. This review examined the evidence of the relationship between SNAP participation and child weight. Read More

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http://dx.doi.org/10.1016/j.amepre.2019.01.006DOI Listing

Differential circulating and visceral fat microRNA expression of non-obese and obese subjects.

Clin Nutr 2019 Apr 8. Epub 2019 Apr 8.

Nutrition and Metabolism Research Division, Korea Food Research Institute, Wanju-gun, Republic of Korea; Department of Food Biotechnology, University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

Background & Aims: Altered microRNA (miRNA) expression is associated with the pathophysiology of obesity; however, little is known about the miRNAs commonly dysregulated in the blood and visceral fat tissue of obese patients. This study compared the circulating and visceral fat miRNA expression in subjects with and without obesity.

Methods: For the circulating miRNA study, 20 healthy control and 30 obese subjects were recruited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193014
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http://dx.doi.org/10.1016/j.clnu.2019.03.033DOI Listing
April 2019
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Nutritional therapy and outcomes in underweight critically ill patients.

Clin Nutr 2019 Apr 5. Epub 2019 Apr 5.

Endocrin Division and Medical Nutrition Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:

Background & Aims: Critically ill patients with body mass index (BMI) < 20 kg/m have worse outcomes than normal/overweight patients possibly because underweight is a marker of malnutrition. To assess the effects of nutrition therapy in this population during the first week of an ICU stay.

Methods: Prospective, 2-centre, observational study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193015
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http://dx.doi.org/10.1016/j.clnu.2019.03.038DOI Listing
April 2019
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Predictors of mortality in patients infected with carbapenem-resistant Acinetobacter baumannii: A systematic review and meta-analysis.

Am J Infect Control 2019 Apr 16. Epub 2019 Apr 16.

Department of Respiratory Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) tops the list of threats to human health. Studies exploring predictors of mortality in patients with CRAB infection produced conflicting results.

Methods: A systematic search of the PubMed, Embase, and the Cochrane Library databases was performed from inception to June 2018 to identify studies reporting mortality predictors in patients infected with CRAB. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.03.003DOI Listing

Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial.

Lancet Diabetes Endocrinol 2019 May;7(5):e6-e17

Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Internal Medicine and Lipid Clinic, Department of Endocrinology and Nutrition, University of Barcelona, Barcelona, Spain.

Background: Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese.

Methods: PREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain. Read More

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http://dx.doi.org/10.1016/S2213-8587(19)30074-9DOI Listing

Analytical Method of Multi-Mycotoxins in Table-Ready Foods for a Total Diet Study Using Stable Isotope Dilution Liquid Chromatography-Tandem Mass Spectrometry.

J AOAC Int 2019 Apr 19. Epub 2019 Apr 19.

Korea Institute of Science and Technology, Advanced Analysis Center, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.

Determining the multi-mycotoxins present in table-ready foods is necessary for a total diet study. However, so far, most methods of analyzing multi-mycotoxins apply to raw foods. Therefore, a reliable method for analyzing multi-mycotoxins in table-ready foods is needed. Read More

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http://dx.doi.org/10.5740/jaoacint.19-0031DOI Listing

A Small In Vitro Fermentation Model for Screening the Gut Microbiota Effects of Different Fiber Preparations.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

VTT Technical Research Centre of Finland, Limited, Post Office Box 1000, Tietotie 2, 02044 Espoo, Finland.

The development of prebiotic fibers requires fast high-throughput screening of their effects on the gut microbiota. We demonstrated the applicability of a mictotiter plate in the in vitro fermentation models for the screening of potentially-prebiotic dietary fibers. The effects of seven rye bran-, oat- and linseed-derived fiber preparations on the human fecal microbiota composition and short-chain fatty acid production were studied. Read More

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https://www.mdpi.com/1422-0067/20/8/1925
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http://dx.doi.org/10.3390/ijms20081925DOI Listing
April 2019
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An End-to-End Image-Based Automatic Food Energy Estimation Technique Based on Learned Energy Distribution Images: Protocol and Methodology.

Nutrients 2019 Apr 18;11(4). Epub 2019 Apr 18.

School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA.

Obtaining accurate food portion estimation automatically is challenging since the processes of food preparation and consumption impose large variations on food shapes and appearances. The aim of this paper was to estimate the food energy numeric value from eating occasion images captured using the mobile food record. To model the characteristics of food energy distribution in an eating scene, a new concept of "food energy distribution" was introduced. Read More

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http://dx.doi.org/10.3390/nu11040877DOI Listing

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.

Antioxidants (Basel) 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.

Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g. Read More

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http://dx.doi.org/10.3390/antiox8040106DOI Listing

Recent Advances in the Use of Sourdough Biotechnology in Pasta Making.

Foods 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Soil, Plant, and Food Science, University of Bari Aldo Moro, 70126 Bari, Italy.

The growing consumers' request for foods with well-balanced nutritional profile and functional properties promotes research on innovation in pasta making. As a staple food and a common component of diet, pasta can be considered as a vector of dietary fiber, vegetable proteins, vitamins, minerals, and functional compounds. The conventional process for pasta production does not include a fermentation step. Read More

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http://dx.doi.org/10.3390/foods8040129DOI Listing