445,375 results match your criteria Nutrition & Diabetes [Journal]


Gut microbiota diversity associates with cardiorespiratory fitness in post-primary treatment breast cancer survivors.

Exp Physiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Nutrition Sciences, University of Alabama at Birmingham.

New Findings: What is the central question of this study? Does the link between cardiorespiratory fitness and gut microbiota diversity persist after adjusting for the potential effects of %body fat and activity-related energy expenditure (AEE)? What is the main finding and its importance? This is the first study to examine the link between cardiorespiratory fitness and gut microbiota diversity while accounting for the underlying effects of %body fat and free-living AEE. Results from the present work suggest cardiorespiratory fitness, not physical activity, is a superior correlate of gut microbiota diversity among post-primary treatment, non-metastatic breast cancer survivors.

Abstract: Cancer treatment uniquely triggers multiple physiologic shifts detrimental to overall health. Read More

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http://dx.doi.org/10.1113/EP087404DOI Listing
February 2019

Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes.

Ann Nutr Metab 2019 Feb 14;74(2):165-174. Epub 2019 Feb 14.

Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, Nevada,

Background: Postprandial metabolic impairments in diabetes have been shown to play an important role in vascular complications. Dietary polyphenols and other bioactive compounds in berries have been shown to improve postprandial hyperglycemia and related metabolic impairments, but few clinical studies have been reported in diabetes.

Objective: To examine the effects of daily dietary raspberries on postprandial and 4-week fasting glucose, lipids and biomarkers of inflammation in obese adults with type 2 diabetes. Read More

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http://dx.doi.org/10.1159/000497226DOI Listing
February 2019

A quercetin-based flavanoid (rutin) reverses amyloid fibrillation in β-lactoglobulin at pH 2.0 and 358 K.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 5;214:40-48. Epub 2019 Feb 5.

Department of Food Science and Nutrition, Faculty of Food and Agricultural Sciences, King Saud University, 2460, Riyadh 11451, Saudi Arabia.

β-lactoglobulin (BLG) is a well characterized milk protein and a model for folding and aggregation studies. Rutin is a quercetin based-flavanoid and a famous dietary supplement. It is a potential protector from coronary heart disease, cancers, and inflammatory bowel disease. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.004DOI Listing
February 2019

Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Alcohol 2018 Aug 24;77:11-18. Epub 2018 Aug 24.

Department of Surgery, Alcohol Research Program, Burn & Shock Trauma Research Institute, Loyola University Chicago Health Sciences Division, Maywood, IL, United States. Electronic address:

On January 26, 2018, the 23rd annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado. The meeting consisted of plenary sessions with oral presentations and a poster presentation session. There were four plenary sessions that covered a wide range of topics relating to alcohol use: Alcohol and Liver Disease; Alcohol, Inflammation and Immune Response; Alcohol and Organ Injury; Heath Consequences and Alcohol Drinking. Read More

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http://dx.doi.org/10.1016/j.alcohol.2018.08.010DOI Listing

Early lead exposure and pubertal development in a Mexico City population.

Environ Int 2019 Feb 11;125:445-451. Epub 2019 Feb 11.

Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Background: Previous studies have examined the association between blood lead levels and pubertal timing in adolescent girls; however, the evidence is lacking on the role of lead exposure during sensitive developmental periods on sexual maturation.

Objectives: To examine the association of prenatal and early childhood lead exposure with pubertal stages among 264 boys and 283 girls aged 9.8-18. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.021DOI Listing
February 2019

Dynamics of intervention adoption, implementation, and maintenance inside organizations: The case of an obesity prevention initiative.

Soc Sci Med 2018 Dec 23;224:67-76. Epub 2018 Dec 23.

Department of Nutrition, Gillings School of Global Public Health, UNC Center for Health Promotion and Disease Prevention (a CDC Prevention Research Center), University of North Carolina at Chapel Hill, NC, USA. Electronic address:

Overall impact of public health prevention interventions relies not only on the average efficacy of an intervention, but also on the successful adoption, implementation, and maintenance (AIM) of that intervention. In this study, we aim to understand the dynamics that regulate AIM of organizational level intervention programs. We focus on two well-documented obesity prevention interventions, implemented in food carry-outs and stores in low-income urban areas of Baltimore, Maryland, which aimed to improve dietary behaviour for adults by providing access to healthier foods and point-of-purchase promotions. Read More

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http://dx.doi.org/10.1016/j.socscimed.2018.12.021DOI Listing
December 2018

Quality of Life Related to Oral Health and its Impact in Adults.

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

MD DDS, PhD. Doctor, Specialist in Stomatology. Professor of Oral Pathology, Faculty of Medicine and Health Sciences (School of Dentistry), Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute), IDIBELL, University of Barcelona, Departament of OdontoestomatologySecond Floor, Room 2.32, Faculty of Medicine and Health Sciences - School of Dentistry Campus Bellvitge, University of Barcelona, Spain.

Oral health is part of general health, and is recognized as an essential component of quality of life (QoL). For years, oral health was determined solely by the clinic, which did not allow an evaluation of the true impact of oral diseases on the patients' daily lives. The development of instruments for assessing QoL related to oral health has occurred due to the urgency of determining the effects of changes in the oral cavity of individuals. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.004DOI Listing
February 2019

Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University Hospital of Verona, Verona, Italy. Electronic address:

Aim: - Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD.

Methods: - We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Read More

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http://dx.doi.org/10.1016/j.diabet.2019.01.011DOI Listing
February 2019

Probiotic Bacillus subtilis CW14 reduces disruption of the epithelial barrier and toxicity of ochratoxin A to Caco-2 cells.

Food Chem Toxicol 2019 Feb 11. Epub 2019 Feb 11.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, China; Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China. Electronic address:

The multiple toxic effects of ochratoxin A (OTA) are a threat for human and animal. This study aimed to examine whether B. subtilis CW14 protected against OTA-induced barrier disruption and cell damage to Caco-2 cells. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.009DOI Listing
February 2019

Characterization of a mutation in the zona pellucida module of Endoglin that causes hereditary hemorrhagic telangiectasia.

Gene 2019 Feb 11. Epub 2019 Feb 11.

Molecular Medicine Department, General Biology and Medical Genetics Unit, University of Pavia, Via Forlanini 14, 27100 Pavia, Italy. Electronic address:

Hereditary hemorrhagic telangiectasia (HHT) is a vascular rare disease characterized by nose and gastrointestinal bleeding, skin and mucosa telangiectasias, and arteriovenous malformations in internal organs. HHT shows an autosomal dominant inheritance and a worldwide prevalence of approximately 1:5000 individuals. In >80% of patients, HHT is caused by mutations in either ENG (HHT1) or ACVRL1 (HHT2) genes, which code for the membrane proteins Endoglin and Activin A Receptor Type II-Like Kinase 1 (ALK1), respectively, both belonging to the TGF-β/BMP signaling pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193012
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http://dx.doi.org/10.1016/j.gene.2019.02.016DOI Listing
February 2019
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Irradiation of mung beans (Vigna radiata): A prospective study correlating the properties of starch and grains.

Int J Biol Macromol 2019 Feb 11. Epub 2019 Feb 11.

Department of Agri-food Industry, Food and Nutrition (LAN), Luiz de Queiroz College of Agriculture (ESALQ), University of São Paulo (USP), Piracicaba, SP, Brazil. Electronic address:

In this work, the effect of Gamma-irradiation was evaluated on the characteristics of mung bean (Vigna radiata) grains and starches, considering doses up to 5 kGy. For this purpose, the starch structure and properties were evaluated, as well as the grains' hydration, germination and cooking. The irradiation process was able to change the characteristics of both mung bean starches and grains. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.221DOI Listing
February 2019

Access to credentialed elementary physical education teachers in California and students' cardiorespiratory fitness.

Prev Med 2019 Feb 11. Epub 2019 Feb 11.

UC Berkeley School of Public Health, 2121 Berkeley Way #5302, Berkeley, CA 94720, United States of America. Electronic address:

Physical education (PE) can improve student health. Schools with credentialed PE teachers receive more PE. However, many schools have reduced PE funding, resulting in fewer teachers and potentially poorer student health. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.01.021DOI Listing
February 2019

The effects of roux en y gastric bypass surgery on neurobehavioral symptom domains associated with severe obesity.

Physiol Behav 2019 Feb 11. Epub 2019 Feb 11.

Department of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States. Electronic address:

Background: Neurobehavioral symptoms and cognitive dysfunction related to mood disorders are present in individuals with severe obesity. We sought to determine acute improvements in these symptoms and relationships with adiposity, inflammation, and insulin sensitivity after roux-en-y gastric bypass (RYGB) surgery.

Methods: The self-report Zung Depression Rating (ZDRS) and Neurotoxicity Rating (NRS) scales were administered before, and at 6-months after RYGB surgery in severely obese women (body mass index > 35 kg/m; N = 19). Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.02.013DOI Listing
February 2019

Waist circumference in relation to outcomes of infertility treatment with assisted reproductive technologies.

Am J Obstet Gynecol 2019 Feb 11. Epub 2019 Feb 11.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Background: Many studies have documented lower likelihood of live birth with increasing body mass index (BMI) among women undergoing assisted reproductive technologies (ART), but few have examined the association with waist circumference (WC), an anthropometric measure that allows assessment of central adiposity.

Objective(s): To examine the relation between baseline WC and infertility treatment outcomes among women undergoing treatment with ART.

Study Design: We followed 264 women who underwent 445 ART cycles for infertility treatment at the Massachusetts General Hospital between 2010 and 2017. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.013DOI Listing
February 2019

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors.

Cell Host Microbe 2019 Feb;25(2):324-335.e4

Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada; Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Winnipeg, MB, Canada. Electronic address:

Breastmilk contains a complex community of bacteria that may help seed the infant gut microbiota. The composition and determinants of milk microbiota are poorly understood. Among 393 mother-infant dyads from the CHILD cohort, we found that milk microbiota at 3-4 months postpartum was dominated by inversely correlated Proteobacteria and Firmicutes, and exhibited discrete compositional patterns. Read More

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http://dx.doi.org/10.1016/j.chom.2019.01.011DOI Listing
February 2019

Documentation of everyday life and health care following gastrostomy tube placement in children: a content analysis of medical records.

Disabil Rehabil 2019 Feb 14:1-11. Epub 2019 Feb 14.

d Department of Research and Development , Region Halland , Halmstad , Sweden.

Background: Everyday routines play a vital role in child functioning and development. This study explored health professionals' documentation of everyday life and health care during the first year following gastrostomy tube placement in children and the content of intervention goals.

Methods: The medical records of 39 children (median age 38 months, min-max: 15-192) in one region of Sweden were analysed. Read More

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http://dx.doi.org/10.1080/09638288.2019.1573383DOI Listing
February 2019

[Secondary lipid oxidation products. Human health risks evaluation (Article 1)].

Vopr Pitan 2018 13;87(6):125-138. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The first article of the series describes possible applications of both proton nuclear magnetic resonance spectroscopy (Н NMR) and Fourier transform infrared spectroscopy (FTIR) in food lipid thermo-oxidation analysis. Thermo-oxidation process is a source of various oxidation products. Some of them are known to be toxic, such as oxidized α,β-unsaturated aldehydes and epoxidized linoleic acid derivatives. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10074DOI Listing
November 2018

[Determination of phthalates in juice product by high-performance liquid chromatography/mass spectrometry].

Vopr Pitan 2018 13;87(6):117-124. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The paper presents the research results obtained after determination of the persistent organic pollutants of the environment - phthalates in domestic juice products with the use of high-performance liquid chromatography/ mass spectrometry (HPLC/MS/MS) with application of solid-phase extraction as a method of sample preparation. Selective determination of phthalates in fruit and vegetable juices by HPLC/MS/MS method has been provided through parent and child ions' monitoring that are formed during ionization of the molecules of the studied compounds in the electrostatic spray of isomers on a reversed-phase column. The analysis of the samples of juice product revealed the presence of 11 phthalates out of 13 studied in concentration range from 0. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10073DOI Listing
November 2018

[Development of a modern methodological base for monitoring the content of vitamins in food and food supplements].

Vopr Pitan 2018 13;87(6):106-116. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The determination of vitamins in various food matrices is necessary for monitoring the quality and safety indicators of food, including the control of the use of vitamins as food additives - food colorings and antioxidants. As well it is necessary to evaluate the level of consumption of vitamins by different age and sex categories of the population. The analysis of the regulatory and methodical basis in the field of determining the content of vitamins in food, including food supplements, has been held. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10072DOI Listing
November 2018

[Grape juice nutritional profile].

Vopr Pitan 2018 13;87(6):95-105. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The nutrient profile of grape juice is presented on the basis of reference books data analysis, scientific publications and research results. The profile contains more than 30 food and biologically active substances (BAS). Grape juice does not have high acidity, it contains on average 0. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10046DOI Listing
November 2018

[Monitoring of selenium content in some food of residents of the Khabarovsk].

Vopr Pitan 2018 13;87(6):89-94. Epub 2018 Nov 13.

Federal Scientific Center of Vegetable Production, Moscow Region, Odintsovo District, VNIISSOK.

The development of about 40 diseases, including cancer and cardiovascular diseases, is associated with a lack of selenium (Se) consumption. According to the previously obtained data, Khabarovsk Krai is characterized by low human selenium status in various age groups and low content in most foods, that is the main reason for the population Se deficit in Khabarovsk territory. To study the content of Se in some foods in Khabarovsk in the comparative aspect. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10070DOI Listing
November 2018

[Specialized food products with modified carbohydrate profile for dietary correction of diet of patients with type 2 diabetes].

Vopr Pitan 2018 13;87(6):76-88. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

In recent years, the incidence of diabetes mellitus (DM) in the world is growing steadily. According to the international diabetes Federation (IDF), the number of DM patients in the world in 2015 was 415 million, of them more than 90% - patients with type 2 diabetes. According to forecasts, in 2040 their number will increase to 642 million. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10069DOI Listing
November 2018

[The prospective of using plant polyphenols as functional food ingredients].

Vopr Pitan 2018 13;87(6):57-66. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

In this review we briefly discuss the publications dedicated to experimental evaluation of hypoglycemic, hypolipidemic and antioxidant properties of different plant polyphenols. The stages of preclinical studies of their efficacy are presented: in silico studies with molecular docking methods and in vivo studies with the use of genetic and medicamental models of type 2 diabetes. The results of own studies present the substantiation of prospects of using the plant polyphenol extracts as functional food ingredients for diet therapy and treatment of patients with type 2 diabetes. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10067DOI Listing
November 2018

[Organization of nutrition of children and adolescents at the regional level].

Vopr Pitan 2018 13;87(6):48-56. Epub 2018 Nov 13.

M.K. Ammosov North-Eastern Federal University, Yakutsk.

The article presents the results of 13-year monitoring epidemiological studies on the actual nutrition and eating habits among children and adolescents studying in educational institutions of the Republic of Sakha (Yakutia). The study used standardized questionnaires, adapted by the Nutrition Center of the Health Institute M.K. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10066DOI Listing
November 2018

[Assessment of the risk of malnutrition in the older age group of the Voronezh Region].

Vopr Pitan 2018 13;87(6):42-47. Epub 2018 Nov 13.

Voronezh State Medical University named after N.N. Burdenko.

Modern scientific data indicate the widespread use in European countries of questioning in assessing the nutritional status of patients. The use of questionnaires in medical practice allows the doctor to reduce the time to collect anamnesis, to place emphasis on building a further algorithm of diagnosis and treatment. The article is devoted to the study of the nutritional status of elderly people in the city of Voronezh and the Region; determining the risk of malnutrition syndrome. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10065DOI Listing
November 2018

[A comparative analysis of actual nutrition of children aged 9-10 years].

Vopr Pitan 2018 13;87(6):28-41. Epub 2018 Nov 13.

Kazakh Academy of Nutrition, Almaty, Republic of Kazakhstan.

Aim of the study is to carry out a comparative analysis of actual nutrition of children aged 9-10 years with different nutritional status, to asses relationships between Energy Value (EV) of diet, BMI and diet composition. The study covers two groups of children residing in Almaty - 80 children aged 9-10 years with obesity (40 boys and 40 girls) and 80 normal-weight children (40 boys and 40 girls). To determine the nutritional status of the children, diagnostic criteria such as BMI-for-Age Z-score tables of WHO growth standards have been used. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10064DOI Listing
November 2018

[Hygienic assessment of indoles in the diet of medical students].

Vopr Pitan 2018 13;87(6):22-27. Epub 2018 Nov 13.

I.M. Sechenov First Moscow State Medical University.

A number of studies have shown the relationship between the regular consumption of cruciferous vegetables and the risk of malignant tumors in certain localizations, the activation of mechanisms of alimentary adaptation of the organism under conditions of alien loads, by inducing enzymes of the biotransformation system of xenobiotics. The cruciferous vegetables are distinguished by the presence of minor components, such as indole-3-carbinol, formed during the hydrolysis of glucosinolates. The aim of the investigation was a retrospective study of the content of indoles in students' diet with subsequent quantitative analysis in different comparison groups. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10063DOI Listing
November 2018

[Effect of quercetin on morphological changes in nonalcoholic fatty liver disease in high fructose-fed rats].

Vopr Pitan 2018 13;87(6):16-21. Epub 2018 Nov 13.

I.M. Sechenov First Moscow State Medical University.

The aim of this study was to examine the effect of polyphenol quercetin on morphological changes in nonalcoholic fatty liver disease (NAFLD) in rats fed high-fructose diet. For 20 weeks animals (n=8 in each group) of the 1st group were given standard diet and water; the 2nd group - standard diet and 20% fructose solution; the 3rd group - standard diet with quercetin supplementation (0.1%) and 20% fructose solution. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10062DOI Listing
November 2018

[Modern approaches to dietary support for patients with diabetic nephropathy].

Vopr Pitan 2018 13;87(6):6-15. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The article presents modern approaches to dietary support of patients with diabetic nephropathy (DN) characterized by gradual sclerosis of the renal tissue, leading to a loss of filtration and nitrogen excretory function of the kidneys. An analysis of publications of domestic and foreign authors indicates a slowdown in the progression of chronic kidney disease against the background of low-protein diets. However, the role of protein restriction and its qualitative composition in the diet of patients with DN is the subject of comprehensive discussion. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10061DOI Listing
November 2018

Dietary Black Raspberries Impact the Colonic Microbiome and Phytochemical Metabolites in Mice.

Mol Nutr Food Res 2019 Feb 14:e1800636. Epub 2019 Feb 14.

J. Gu, J. M. Thomas-Ahner, K. M. Riedl, M. T. Bailey, Y. Vodovotz, S. J. Schwartz, S. K. Clinton, Comprehensive Cancer Center, The Ohio State University, Columbus, OH.

Scope: Black raspberries (BRB) are a rich source of bioactive phytochemicals, including anthocyanins and ellagitannins. These phytochemicals are poorly absorbed and we hypothesize that upon reaching the colon they may be transformed by gut microbiota into various metabolites that may impact the colonic mucosa or upon absorption have systemic bioactivity. The objective of this study was to define the impact of a BRB-containing diet on the colon microbiome in mice and quantify the phytochemical metabolites in the colon contents and the circulation. Read More

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http://dx.doi.org/10.1002/mnfr.201800636DOI Listing
February 2019

Alternative (backdoor) androgen production and masculinization in the human fetus.

PLoS Biol 2019 Feb 14;17(2):e3000002. Epub 2019 Feb 14.

Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.

Masculinization of the external genitalia in humans is dependent on formation of 5α-dihydrotestosterone (DHT) through both the canonical androgenic pathway and an alternative (backdoor) pathway. The fetal testes are essential for canonical androgen production, but little is known about the synthesis of backdoor androgens, despite their known critical role in masculinization. In this study, we have measured plasma and tissue levels of endogenous steroids in second trimester human fetuses using multidimensional and high-resolution mass spectrometry. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000002DOI Listing
February 2019

Notch and Nonalcoholic Fatty Liver and Fibrosis.

Authors:
Stefano Romeo

N Engl J Med 2019 Feb;380(7):681-683

From the Department of Molecular and Clinical Medicine, University of Gothenburg, and the Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden; and the Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.

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http://dx.doi.org/10.1056/NEJMcibr1815636DOI Listing
February 2019

Impact of hepatitis C virus and insurance coverage on mortality.

Am J Manag Care 2019 Feb;25(2):61-67

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Claude Moore Health Education and Research Building, 3300 Gallows Rd, Falls Church, VA 22042. Email:

Objectives: To assess the association of payer status and mortality in hepatitis C virus (HCV)-infected patients.

Study Design: For this retrospective observational study, we used the National Health and Nutrition Examination Survey from 2000 to 2010. Adults with complete data on medical questionnaires, HCV RNA, insurance types, and mortality follow-ups were included. Read More

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February 2019
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[Vegan diet in children : what potential deficits to monitor ?]

Rev Med Suisse 2019 Feb;15(638):373-375

Ostschweizer Kinderspital, 9000 St. Gallen.

The vegan diet, although beneficial for adults in the prevention of metabolic diseases, raises questions about its benefits for a growing child : adequate caloric and protein intake, quality of essential amino acids, presence of essential fatty acids, inhibition of absorption of trace elements (including iodine, iron and zinc) and supply of various vitamins. Whereas vegan food is vitamin B12 deprived, the biggest challenge remains the vitamin B12 substitution in pregnant women, breastfeeding mothers and children at any age. Specific management by pediatricians using dietetic support and blood analyzes are required for children under vegan diet with respect of moral and ethical values related to this lifestyle choice. Read More

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February 2019

Gut microbiota signatures and lipids metabolism profiles by exposure to polyene phosphatidylcholine.

Biofactors 2019 Feb 14. Epub 2019 Feb 14.

Department of Food Science & Nutrition, Zhejiang University, Hangzhou, China.

The aim of the study was to address the causality links and identify specific features of the gut microbiota signatures contributing to host lipids metabolism in the presence or absence of polyene phosphatidylcholine (PPC) administration, and evaluate potential risk of PPC consumption. About 20 C57BL/6J mice were randomly allocated into two groups, normal diet group (CK) and PPC administration group (205.2 mg/kg). Read More

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http://dx.doi.org/10.1002/biof.1495DOI Listing
February 2019

Identifying the health problems of slum residents using social determinants of health: Kerman, Iran.

Int J Health Plann Manage 2019 Feb 14. Epub 2019 Feb 14.

Healthcare Management, School of Management and Medical Information, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: Although slum emerged in industrialized countries, today, all cities in the world are somehow facing this phenomenon. Slums create many problems in different areas, especially health for residents. Therefore, this research was conducted with the aim of identifying the health problems of the slum residents of Kerman city by using the social determinant of health approach. Read More

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http://dx.doi.org/10.1002/hpm.2755DOI Listing
February 2019

Patient costs of hypertension care in public health care facilities in Kenya.

Int J Health Plann Manage 2019 Feb 14. Epub 2019 Feb 14.

Health Economics Research Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.

Background: Hypertension in low- and middle-income countries, including Kenya, is of economic importance due to its increasing prevalence and its potential to present an economic burden to households. In this study, we examined the patient costs associated with obtaining care for hypertension in public health care facilities in Kenya.

Methods: We conducted a cross-sectional study among adult respondents above 18 years of age, with at least 6 months of treatment in two counties. Read More

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http://dx.doi.org/10.1002/hpm.2752DOI Listing
February 2019

Soluble fibers improve metabolic syndrome but may cause liver disease and hepatocellular carcinoma.

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY, 10032, USA.

Nearly 25% of the world's population is suffering from non-alcoholic fatty liver disease (NAFLD), which is closely associated with obesity and type 2 diabetes. NAFLD may progress to the development of non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). With efficient medical therapies lacking, modifications of life style and diet are considered the best options for the prevention and treatment of NAFLD. Read More

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http://dx.doi.org/10.1002/hep.30565DOI Listing
February 2019

Sarcopenia for predicting mortality among elderly nursing home residents: SARC-F versus SARC-CalF.

Medicine (Baltimore) 2019 Feb;98(7):e14546

Health Management Center, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu, Sichuan, China.

Little is known about the prognostic value of the strength, assistance walking, rise from a chair, climb stairs, and falls questionnaire (SARC-F) and SARC-F combined with calf circumference (SARC-CalF) among elderly nursing home residents.To compare the prognostic value of SARC-F and SARC-CalF for mortality in this population.We conducted a prospective study in four nursing homes in western China. Read More

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http://dx.doi.org/10.1097/MD.0000000000014546DOI Listing
February 2019

Association between smoking and serum uric acid in Korean population: Data from the seventh Korea national health and nutrition examination survey 2016.

Medicine (Baltimore) 2019 Feb;98(7):e14507

The aim of this study was to identify any association between serum uric acid and smoking status using data from the Seventh Korea National Health and Nutrition Examination Survey (KNHANES VII-1) 2016 of the Korean population.This study used a cross-sectional design and analyzed 5609 subjects aged ≥ 19 years among 8150 participants enrolled in the KNHANES VII-1 2016. Smoking status was classified into current smokers, never smokers, and ex-smokers. Read More

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http://dx.doi.org/10.1097/MD.0000000000014507DOI Listing
February 2019

The triad of diabetes ketoacidosis, hypertriglyceridemia and acute pancreatitis. How does it affect mortality and morbidity?: A 10-year analysis of the National Inpatient Sample.

Medicine (Baltimore) 2019 Feb;98(7):e14378

Gastroenterology and Hepatology Department, Digestive Disease Institute.

The triad of acute pancreatitis (AP) coexisting with diabetes ketoacidosis (DKA) and hypertriglyceridemia (HTG) has been reported, but no impact on mortality has been found to date. We aim to assess if patients with this triad are at a higher inpatient mortality compared to patients with acute pancreatitis only.Retrospective cohort. Read More

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http://dx.doi.org/10.1097/MD.0000000000014378DOI Listing
February 2019

Current status of graft-versus-host disease after intestinal transplantation.

Curr Opin Organ Transplant 2019 Feb 11. Epub 2019 Feb 11.

Division of Pediatric Transplantation, Department of Surgery, Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh, Thomas E. Starzl Transplant Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA.

Purpose Of Review: Over the past decades, visceral transplantation has become the standard of care for patients with irreversible intestinal failure who suffer complications of total parenteral nutrition (TPN). Graft-versus-host disease (GVHD) after solid organ transplantation is a rare but often fatal complication with high mortality. GVHD after intestinal transplantation, given the large lymphoid content of the graft, is more frequent compared with other solid organs. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000624DOI Listing
February 2019

Current status of lipid emulsions in the prevention of intestinal failure-associated liver disease.

Curr Opin Organ Transplant 2019 Feb 11. Epub 2019 Feb 11.

Department of Gastroenterology, Hepatology, and Nutrition, Children's Mercy.

Purpose Of Review: The current review provides a summary of available lipid products and discusses current literature and the limitations to the use of various lipid products for treatment and prevention of intestinal failure-associated liver disease (IFALD) in pediatric patients dependent on parenteral nutrition.

Recent Findings: Improvements in markers of cholestasis and liver function have been seen with minimizing soybean lipid, fish oil lipid, and mixed fish oil-containing lipid emulsions. Soybean-based lipid products are thought to be the biggest contributor to development of IFALD. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000620DOI Listing
February 2019

The impact of smoking on response to TNF inhibitors in axial spondyloarthritis: methodological considerations for longitudinal observational studies.

Arthritis Care Res (Hoboken) 2019 Feb 14. Epub 2019 Feb 14.

Musculoskeletal biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

Objective: Observational data facilitate examination of treatment-effect heterogeneity, but the risk of bias is substantial. We highlight methodological considerations through an analysis of whether smoking affects response to TNF inhibitors (TNFi) in axial spondyloarthritis (axSpA).

Methods: We used longitudinal data from the British Society for Rheumatology Biologics Register for Ankylosing Spondylitis. Read More

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http://dx.doi.org/10.1002/acr.23851DOI Listing
February 2019

Oral nutritional supplements and 30-day readmission rate in hypoalbuminemic maintenance hemodialysis patients.

Hemodial Int 2019 Feb 14. Epub 2019 Feb 14.

Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.

Introduction: Hemodialysis (HD) patients are hospitalized nearly twice yearly, and 35% of these patients are rehospitalized within 30-days postdischarge. We hypothesized that monitored oral nutritional supplementation (ONS) during HD treatment may decrease readmissions.

Methods: A cohort of maintenance HD patients, treated at a large dialysis organization, who were hospitalized with a postdischarge albumin of ≤3. Read More

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http://dx.doi.org/10.1111/hdi.12694DOI Listing
February 2019

The effect of cumin supplementation on metabolic profiles in patients with metabolic syndrome: A randomized, triple blind, placebo-controlled clinical trial.

Phytother Res 2019 Feb 14. Epub 2019 Feb 14.

Student Research Committee, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Metabolic syndrome (MetS) is a cluster of interconnected serious disorders, which is a major health problem whose prevalence is increasing. Oxidative stress and inflammation contribute to the disease pathogenesis and its complications. The present study aimed to investigate the effect of Cuminum cyminum L. Read More

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http://dx.doi.org/10.1002/ptr.6313DOI Listing
February 2019

Docosahexaenoic acid (22:6n-3) Ameliorated the Onset and Severity of Experimental Autoimmune Encephalomyelitis in Mice.

Lipids 2019 Feb 14. Epub 2019 Feb 14.

USDA, ARS, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA.

Multiple sclerosis (MS) is a neurologic autoimmune disease, which is the leading cause of nontraumatic neurologic disability in young adults in United States and Europe. n-3 polyunsaturated fatty acids (PUFA) are reported to mitigate severity of this disease. Recent studies suggest that phospholipid (PL) form of dietary n-3 PUFA may lead to their higher tissue accretion than triacylglycerol (TAG) form. Read More

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http://dx.doi.org/10.1002/lipd.12130DOI Listing
February 2019

The use of fluoride for the prevention of dental erosion and erosive tooth wear in children and adolescents.

Eur Arch Paediatr Dent 2019 Feb 14. Epub 2019 Feb 14.

Department of Restorative, Preventive, and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland.

Background: Erosive tooth wear (ETW) has gained increasing clinical relevance. It is estimated that worldwide 30-50% of deciduous and 20-45% of permanent teeth are affected. One of the most important nutritional factors causing ETW is the overconsumption of soft drinks, but also patient-related factors like reflux or eating disorders can lead to erosive lesions. Read More

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http://dx.doi.org/10.1007/s40368-019-00420-0DOI Listing
February 2019