452,958 results match your criteria Nutrition & Diabetes [Journal]


Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota-brain axis.

J Neurochem 2019 Apr 21. Epub 2019 Apr 21.

Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

The gut microbiota is increasingly recognized to modulate brain function by recent studies demonstrating the central effects of various gut microbial manipulation strategies. Our previous study demonstrated that antibiotics-induced alterations of hindgut microbiota are associated with changes in aromatic amino acid (AAA) metabolism and hypothalamic neurochemistry, while the underlying mechanism insight is limited. Given that the microbial AAA metabolism can be affected by luminal carbohydrate availability, here we hypothesize that increasing hindgut carbohydrate availability affects the expression of neurotransmitters in the porcine hypothalamus. Read More

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http://dx.doi.org/10.1111/jnc.14709DOI Listing

Management of postoperative chylous ascites after surgery for ovarian cancer: a single-institution experience.

Updates Surg 2019 Apr 20. Epub 2019 Apr 20.

Division of Gynecologic Oncology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Postoperative chylous ascites is a rare complication from operative trauma to the cisterna chyli or lymphatic vessels in the retroperitoneum. In the present study, we aimed to identify the incidence of postoperative chylous ascites in patients treated for ovarian cancer and to describe its management. We retrospectively reviewed all patients submitted to surgery for ovarian cancer at our Institution from October 2016 to November 2018. Read More

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http://dx.doi.org/10.1007/s13304-019-00656-xDOI Listing

Micronutrient status and leukocyte telomere length in school-age Colombian children.

Eur J Nutr 2019 Apr 20. Epub 2019 Apr 20.

Department of Epidemiology, University of Michigan School of Public Health, Room 5507 SPH II, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.

Purpose: Leukocyte telomere length (LTL) is a biomarker of inflammation and oxidative stress that predicts chronic disease risk. Nutritional factors are related to LTL in adulthood, but these associations are not well characterized in children. We examined whether micronutrient status biomarkers were associated with LTL in school-age children. Read More

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http://dx.doi.org/10.1007/s00394-019-01966-xDOI Listing

Non-communicable disease prevention in Mexico: policies, programs and regulations.

Health Promot Int 2019 Apr 21. Epub 2019 Apr 21.

University of Arizona, Mel and Enid Zuckerman College of Public Health, 1296 N. Martin, Tucson, AZ 85724, USA.

Non-communicable diseases (NCD), such as diabetes and cardiovascular disease, have become a leading cause of the death in Mexico. The federal government has addressed this issue through developing NCD prevention plans, regulations and policies (PRPs) that seek to address social and environmental factors, which was led by the National Institute of Public Health and Ministry of Health in concert with various non-governmental organizations. This review aims to synthesize and summarize national NCD prevention PRPs addressing social and environmental factors passed from 2010 to 2016, and to assess the extent to which these efforts successfully addressed factors contributing to the epidemic. Read More

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http://dx.doi.org/10.1093/heapro/daz029DOI Listing

Advocacy coalitions and the transfer of nutrition policy to Zambia.

Authors:
Jody Harris

Health Policy Plan 2019 Apr 21. Epub 2019 Apr 21.

Institute of Development Studies, Library Road, University of Sussex, BN1 9RE, Brighton, UK.

Stunted growth in children and multisectoral action to address it are dominant ideas in the international nutrition community today, and this study finds that these ideas are increasingly evident over time in nutrition policy in Zambia, with stunting largely displacing other framings of nutrition. This study is based on key informant interviews (70 interviews with 61 interviewees), policy document review, and social network mapping, with iterative data collection and analysis taking place over 6 years (2011-2016). Analysis was based on two established political science theories: policy transfer theory and the Advocacy Coalition Framework. Read More

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https://academic.oup.com/heapol/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/heapol/czz024DOI Listing
April 2019
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Cardiovascular manifestations of sickle cell disease.

Eur Heart J 2019 Apr 21. Epub 2019 Apr 21.

Sorbonne Université, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), ACTION Study Group and Department of Cardiology, Institute of Cardiology (AP-HP), Hôpital Pitié- Salpêtrière, Boulevard de l'hôpital, Paris F-75013, France.

Sickle cell disease (SCD) is the most frequent genetic haemoglobinopathy worldwide. Early childhood mortality has dramatically decreased in high-income countries, and most patients now survive beyond the 5th decade. However, in the aging SCD population, the morbidity related to chronic organ damage, especially kidney and heart, has become a major concern. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz217DOI Listing

Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Center for Human Nutrition, David Geffen School of Medicine, Division of Molecular Medicine, Department of Anesthesiology, University of California, Los Angeles, CA.

Background: Recent studies have shown that circulating branched-chain amino acids (BCAAs) are elevated in obese, insulin-resistant individuals. However, it is not known if supplementation of additional BCAAs will further impair glucose metabolism.

Objectives: The aim of this pilot study was to determine the effects of BCAA supplementation on glucose metabolism in obese, prediabetic individuals. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqz024DOI Listing
April 2019
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New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Monell Chemical Senses Center, Philadelphia, PA.

Background: Individual differences in human perception of sweetness are partly due to genetics; however, which genes are associated with the perception and the consumption of sweet substances remains unclear.

Objective: The aim of this study was to verify previous reported associations within genes involved in the peripheral receptor systems (i.e. Read More

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http://dx.doi.org/10.1093/ajcn/nqz043DOI Listing

The MTHFR 677C>T polymorphism is associated with unmetabolized folic acid in breast milk in a cohort of Canadian women.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Nutrition Research Division.

Background: Maternal nutrition and genetics are determinants of breast-milk nutrient composition and, as such, are determinants of the nutritional exposure of breastfed infants.

Objectives: The aim of this study was to determine whether common maternal single nucleotide polymorphisms (SNPs) in folate-dependent enzymes are associated with breast-milk folate content in a cohort of mothers enrolled in the Maternal-Infant Research on Environmental Chemicals (MIREC) study.

Methods: The MIREC study is a Canadian prospective pregnancy cohort study that recruited 2001 participants between 2008 and 2011. Read More

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http://dx.doi.org/10.1093/ajcn/nqz056DOI Listing

Habitual coffee consumption and risk of falls in 2 European cohorts of older adults.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, IdiPaz (Instituto de Investigación Sanitaria Hospital Universitario La Paz), and CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.

Background: Habitual coffee consumption has been associated with lower risk of type 2 diabetes, cardiovascular disease, and sarcopenia, which are strong risk factors of falls. In addition, caffeine intake stimulates attention and vigilance, and reduces reaction time. Therefore, a protective effect of coffee on the risk of falling can be hypothesized. Read More

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http://dx.doi.org/10.1093/ajcn/nqy369DOI Listing

Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Department of Clinical Science, KG Jebsen Centre for Diabetes Research, University of Bergen, Bergen, Norway.

Background: Elevated circulating cystathionine levels are related to atherosclerotic cardiovascular disease, a leading cause of death globally.

Objective: We investigated whether plasma cystathionine was associated with mortality in patients with suspected or established coronary heart disease (CHD).

Methods: Data from 2 independent cohorts of patients with suspected stable angina pectoris (SAP) (3033 patients; median 10. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqy391DOI Listing
April 2019
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Association between taste perception and adiposity in overweight or obese older subjects with metabolic syndrome and identification of novel taste-related genes.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.

Background: The relation between taste perception, diet, and adiposity remains controversial. Additionally, there is a lack of knowledge on the polymorphisms influencing taste given the scarcity of genome-wide association studies (GWASs) published.

Objectives: We studied the relation between perception of the basic tastes, i. Read More

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http://dx.doi.org/10.1093/ajcn/nqz038DOI Listing

Health/nutritional status of immigrant Pakistani laborers working in the Kingdom of Saudi Arabia.

Rev Environ Health 2019 Apr 22. Epub 2019 Apr 22.

School of Food and Agricultural Sciences, University of Management and Technology, Lahore, Pakistan, Phone: +92-333-5278329, Fax: +92 42 35184789.

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http://dx.doi.org/10.1515/reveh-2019-0018DOI Listing

Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry.

BMJ Open 2019 Apr 20;9(4):e027535. Epub 2019 Apr 20.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.

Objectives: This analysis examined the association between psoriasis severity, assessed by body surface area (BSA) and the Investigator's Global Assessment (IGA; previously used only in clinical trials), and patient-reported outcomes (PROs) in a real-world setting.

Design: Cross-sectional analysis within the Corrona Psoriasis Registry, an independent, prospective registry.

Setting: 70 dermatology practices in the USA. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027535DOI Listing

Protocol for the Gut Bugs Trial: a randomised double-blind placebo-controlled trial of gut microbiome transfer for the treatment of obesity in adolescents.

BMJ Open 2019 Apr 20;9(4):e026174. Epub 2019 Apr 20.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Introduction: Animal studies showed that germ-free mice inoculated with normal mouse gut bacteria developed obesity, insulin resistance and higher triglyceride levels, despite similar food intake. In humans, an association has been found between obesity and gut microbiome dysbiosis. However, gut microbiome transfer has not been evaluated for the treatment of human obesity. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02617
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http://dx.doi.org/10.1136/bmjopen-2018-026174DOI Listing
April 2019
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Patient expectations of a new treatment for eating disorders combining guided physical exercise and dietary therapy: an interview study of women participating in a randomised controlled trial at the Norwegian School of Sport Sciences.

BMJ Open 2019 Apr 20;9(4):e025344. Epub 2019 Apr 20.

Department of Sports Medicine, Norwegian School of Sport Sciences, Norway, Europe.

Objectives: To study the expectations women with bulimia nervosa (BN) or binge eating disorder (BED) had to a new treatment programme based on guided physical exercise and dietary therapy.

Design And Participants: Semistructured interviews were conducted with six women with BN and four women with BED following a group-based therapy programme. Transcribed interviews were analysed using a text-condensing analytic approach. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025344DOI Listing

Diet quality in relation to healthy ageing: the Israeli Longitudinal Study on Aging (ILSA)-a study protocol.

BMJ Open 2019 Apr 20;9(4):e024673. Epub 2019 Apr 20.

Department of Epidemiology and Preventive Medicine, Tel Aviv University, Tel Aviv, Israel.

Introduction: Population ageing is accelerating rapidly in Israel as well as worldwide, necessitating adaptation of the healthcare system and consideration of new approaches that serve the specific needs of older adults. In addition to cognitive function, frailty is one of the most challenging expressions of physical and mental ageing, a multidimensional syndrome of increased vulnerability. Several studies have shown that low intake of certain micronutrients and protein is associated with higher risk of frailty and cognitive impairment. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024673DOI Listing

Smoking does not protect patients with axial spondyloarthritis from attacks of uveitis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Musculoskeletal biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK

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http://dx.doi.org/10.1136/annrheumdis-2019-215348DOI Listing

Crohn's disease initiated with extraintestinal features.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts, USA.

Crohn's disease (CD) is a multifactorial, chronic immune-mediated disorder. The oral cavity is involved in 0.5% to 20% of the patients with CD. Read More

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http://dx.doi.org/10.1136/bcr-2019-229916DOI Listing
April 2019
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Disease of the past re-emerging in modern Australian society.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Infectious Diseases, Blacktown Hospital, Blacktown, New South Wales, Australia.

A 28-year-old man with fever, atraumatic lower limb pain and rash was noted to have multiple areas of ecchymosis involving both lower limbs. He was anaemic and also had a grossly swollen left leg. Differential diagnoses of compartment syndrome, vascular tear, platelet and clotting factor disorders, vasculitis and myositis were ruled out. Read More

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http://dx.doi.org/10.1136/bcr-2018-228448DOI Listing

Click chemistry approach to characterize curcumin-protein interactions in vitro and in vivo.

J Nutr Biochem 2019 Mar 10;68:1-6. Epub 2019 Mar 10.

Department of Food Science, University of Massachusetts, Amherst, MA, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA. Electronic address:

Curcumin, a bis-α, β-unsaturated β-diketon dietary compound from turmeric, is among the most promising dietary compounds for preventing chronic diseases. Previous research has shown that curcumin is highly reactive toward protein thiols to form curcumin-protein adducts, however, the interactions of curcumin with proteins are under-studied. Here we report the design and synthesis of "click" chemistry probes of curcumin, mono-propargyl curcumin (mono-Cur) and di-propargyl curcumin (di-Cur), and use the click probes to study curcumin-proteins interactions in vitro and in vivo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09552863193004
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http://dx.doi.org/10.1016/j.jnutbio.2019.02.010DOI Listing
March 2019
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Green propolis extract promotes in vitro proliferation, differentiation, and migration of bone marrow stromal cells.

Biomed Pharmacother 2019 Apr 18;115:108861. Epub 2019 Apr 18.

Tissue Regeneration Laboratory, Department of Large Animal Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA. Electronic address:

Background: Propolis is a resinous material extracted from bee glue with a complex chemical composition. The unique biological properties of propolis have led to its use in alternative medicine and as a nutritional supplement. Recent research shows that propolis could affect the immune system by decreasing the production of inflammatory cytokines and potentiating an effect on resident stem cells. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108861DOI Listing

Assessment of the benefit-risk balance of SGLT2 inhibitors: commentary on a new 'French paradox'.

Diabetes Metab 2019 Apr 18. Epub 2019 Apr 18.

Service de Diabétologie, Centre Hospitalier Universitaire Rangueil, Toulouse, France.

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http://dx.doi.org/10.1016/j.diabet.2019.04.001DOI Listing
April 2019
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Exercise-induced anti-inflammatory effects in overweight/obese women with polycystic ovary syndrome.

Cytokine 2019 Apr 18;120:66-70. Epub 2019 Apr 18.

Applied Physiology & Nutrition Research Group, Laboratory of Assessment and Conditioning in Rheumatology, School of Physical Education and Sport, School of Medicine, University of São Paulo, Brazil; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil. Electronic address:

Polycystic ovary syndrome (PCOS) is characterized by exacerbated inflammation, which is implicated in cardiometabolic dysfunction. This study aimed to examine the potential effects of acute exercise on inflammatory responses in obese/overweight PCOS women and their controls. Participants underwent a single bout of moderate-intensity aerobic exercise (30 min at ∼65% of VO). Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.006DOI Listing

Improving blood pressure control in primary care: The ImPress study.

Int J Nurs Stud 2019 Apr 4;95:28-33. Epub 2019 Apr 4.

Faculty of Health Sciences and Medicine, Bond University, Queensland, Australia.

Background: Hypertension is a preventable risk factor for cardiovascular disease, the leading cause of death globally. When hypertension is present with tobacco smoking, poor nutrition, physical inactivity or excessive alcohol consumption, risk of cardiovascular disease is increased. Given the prolonged engagement and ongoing relationship with patients, general practice nurses are ideally situated to actively engage with patients about optimal blood pressure control and lifestyle risk reduction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00207489193008
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http://dx.doi.org/10.1016/j.ijnurstu.2019.03.019DOI Listing
April 2019
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In vitro assessment of edoxaban anticoagulant effect in pediatric plasma.

Thromb Res 2019 Apr 13;178:112-118. Epub 2019 Apr 13.

CHU Clermont-Ferrand, Service d'Hématologie Biologique, Clermont-Ferrand, France; Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France.

Introduction: Anticoagulant therapy in pediatric patients remains an issue and safer therapies, such as direct oral anticoagulants could overcome the limitations of conventional anticoagulant treatments in this population. Edoxaban, a factor Xa inhibitor, is used for the prevention and treatment of venous thromboembolism. Due to its pharmacokinetic characteristics, edoxaban is a promising candidate molecule for children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848193020
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http://dx.doi.org/10.1016/j.thromres.2019.04.014DOI Listing
April 2019
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Detecting geriatric needs in older patients with breast cancer through use of a brief geriatric screening tool.

J Geriatr Oncol 2019 Apr 17. Epub 2019 Apr 17.

Duke University Medical Center, Durham, NC, United States of America. Electronic address:

Introduction: Identification of geriatric syndromes is important for determining functional age and optimizing care for people with cancer. Based on administration of a geriatric screening tool, we aimed to describe needed resources for geriatric syndromes, including lack of social support, depressed mood, deficits in instrumental and activities of daily living (IADL/ADL), falls, nutritional issues, polypharmacy, ability to pay for medications, and memory deficits, in a population of patients with breast cancer.

Methods: Consecutive medical oncology patients with breast cancer age 65 years and older, seen at a tertiary care center, completed a screening tool, adapted from Overcash 2006, consisting of a nurse-administered memory assessment and a one-page, self-administered questionnaire. Read More

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http://dx.doi.org/10.1016/j.jgo.2019.04.010DOI Listing

The association between vitamin D status and metabolic syndrome and its components among female teachers residing in Yazd city.

Endocrinol Diabetes Nutr 2019 Apr 17. Epub 2019 Apr 17.

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Background: Studies trying to find the association between vitamin D status and metabolic syndrome (MetS) have led to inconsistent results, and community-based data for individuals living in the Middle East are limited.

Objectives: To find out if MetS and its components are associated with vitamin D status among female teachers residing in Yazd city during winter 2015.

Materials And Methods: A total of 276 female teachers (case group, n=124 and control group, n=152) aged 20-60 years were included. Read More

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http://dx.doi.org/10.1016/j.endinu.2019.02.006DOI Listing

Whey Protein in Cancer Therapy: A Narrative Review.

Pharmacol Res 2019 Apr 18. Epub 2019 Apr 18.

Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, Goiás, Brazil. Electronic address:

Cancer remains a public health challenge in the identification and development of ideal pharmacological therapies and dietary strategies. The use of whey protein as a dietary strategy is widespread in the field of oncology. The two types of whey protein, sweet or acid, result from several processing techniques and possess distinct protein subfraction compositions. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.04.019DOI Listing

Feasibility of a Family Meal Intervention to Address Nutrition, Emotional Wellbeing, and Food Insecurity of Families With Adolescents.

J Nutr Educ Behav 2019 Apr 17. Epub 2019 Apr 17.

Le Va, Manukau City, New Zealand.

Objective: To assess the feasibility of a family meal intervention to address indicators of parent and adolescent nutrition and well-being and household food security.

Methods: Nine adolescents and a parent/caregiver were recruited from a youth health clinic. Families were provided with meal plans, recipes, and ingredients for 5 meals weekly for 4 weeks. Read More

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http://dx.doi.org/10.1016/j.jneb.2019.03.015DOI Listing

Influence of nutritional factors and the PON1 C(-107)T polymorphism on paraoxonase-1 activity in childhood.

J Pediatr (Rio J) 2019 Apr 18. Epub 2019 Apr 18.

Universidade Federal de Pelotas (UFPel), Faculdade de Nutrição, Pelotas, RS, Brazil. Electronic address:

Objective: The cardioprotective enzyme paraoxonase-1 (PON1) suffers an important influence from genetic polymorphisms and nutritional factors. The aim of this study was to investigate the influence of diet, nutritional status, and the C(-107)T polymorphism on PON1 arylesterase activity in children.

Methods: This was a cross-sectional study with 97 children, aged between 5 and 8 years, of both genders, from a pediatric outpatient clinic in southern Brazil. Read More

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http://dx.doi.org/10.1016/j.jped.2019.02.004DOI Listing

Trends in Energy Drink Consumption Among U.S. Adolescents and Adults, 2003-2016.

Am J Prev Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Introduction: Energy drinks refer to non-alcoholic beverages that contain caffeine, amino acids, herbs, and vitamins. Although energy drinks are marketed to reduce fatigue and improve physical/mental performance, frequent consumption of these beverages has been linked to negative health consequences. The purpose of this study is to provide timely, national estimates of the percentage of energy drink consumers in the U. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797193002
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http://dx.doi.org/10.1016/j.amepre.2018.12.007DOI Listing
April 2019
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Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome.

J Mol Diagn 2019 Apr 15. Epub 2019 Apr 15.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Texas Children's Microbiome Center, Texas Children's Hospital, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas. Electronic address:

Accurate diagnosis and stratification of children with irritable bowel syndrome (IBS) remain challenging. Given the central role of recurrent abdominal pain in IBS, we evaluated the relationships of pediatric IBS and abdominal pain with intestinal microbes and fecal metabolites using a comprehensive clinical characterization and multiomics strategy. Using rigorous clinical phenotyping, we identified preadolescent children (aged 7 to 12 years) with Rome III IBS (n = 23) and healthy controls (n = 22) and characterized their fecal microbial communities using whole-genome shotgun metagenomics and global unbiased fecal metabolomic profiling. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.006DOI Listing

Identification of candidate genes in regulation of spermatogenesis in sheep testis following dietary vitamin E supplementation.

Anim Reprod Sci 2019 Apr 10. Epub 2019 Apr 10.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR China. Electronic address:

Dietary vitamin E supplementation is beneficial to semen quality in different sheep and goat breeds. The aim of this research was to further investigate the effect of vitamin E in sheep on spermatogenesis and its regulatory mechanisms using RNA-seq. Thirty male Hu lambs were randomly divided into three groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784320183091
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http://dx.doi.org/10.1016/j.anireprosci.2019.04.003DOI Listing
April 2019
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Short communication: Heart rate variability, step, and rumination behavior of dairy cows milked in a rotary milking system.

J Dairy Sci 2019 Apr 17. Epub 2019 Apr 17.

MTA-SZIE Large Animal Clinical Research Group, Üllő, Dóra major H-2225, Hungary.

Step behavior, heart rate (HR), the high-frequency (HF) component of heart rate variability (HRV), the ratio of the low-frequency (LF) and HF components (LF/HF ratio) as well as rumination behavior during milking were investigated in dairy cows milked in a high-capacity rotary milking system (n = 49) to study animals' stress responses to the milking process. Cardiac parameters were analyzed for undisturbed standing (baseline) and for the stages of the morning, afternoon, and evening milking processes (i.e. Read More

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http://dx.doi.org/10.3168/jds.2018-15842DOI Listing

Adaptive responses in short-chain fatty acid absorption, gene expression, and bacterial community of the bovine rumen epithelium recovered from a continuous or transient high-grain feeding.

J Dairy Sci 2019 Apr 17. Epub 2019 Apr 17.

Institute of Animal Nutrition and Functional Plant Compounds, 1210 Vienna, Austria; Animal Gut Health Research Cluster, 1210 Vienna, Austria.

The feeding of high-grain diets to dairy cows commonly results in lowered pH and ruminal dysbiosis, characterized by changes in absorption dynamics of short-chain fatty acids (SCFA) across the reticuloruminal wall, epithelial function, and the epithelial bacteria community structure. Therefore, the present study evaluated the effect of high-grain feeding persistence on the absorption kinetics of reticuloruminal SCFA, gene expression in the rumen epithelium, and the associated shifts in the epithelial bacteria in cows recovering from either a long-term continuous high-grain feeding model or a long-term transient high-grain feeding model. In a crossover study design, 8 nonlactating Holstein cows were fed 60% concentrate either continuously for 4 wk (continuous) or with a 1-wk break in the second week of the high-grain feeding (transient). Read More

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http://dx.doi.org/10.3168/jds.2018-15691DOI Listing

Reply.

J Pediatr 2019 Apr 17. Epub 2019 Apr 17.

Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology, and Nutrition, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jpeds.2019.03.019DOI Listing

CDK9 modulates circadian clock by attenuating REV-ERBα activity.

Biochem Biophys Res Commun 2019 Apr 17. Epub 2019 Apr 17.

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Nutrition and Health, Shanghai Institute for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. Electronic address:

Circadian clock and cell cycle are vital cellular programs acting in a timely-regulated, cyclic manner. The two cellular oscillators are coupled in various ways to facilitate biological processes. Here we report CDK9, a kinase belongs to the CDK family in regulating cell cycle and RNA Pol II activity, can serve as a modulator for circadian clock. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.043DOI Listing

APOC3 promotes TNF-α-induced expression of JAM-1 in endothelial cell via PI3K-IKK2-p65 pathway.

Cardiovasc Pathol 2019 Mar 4;41:11-17. Epub 2019 Mar 4.

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, 20 Xi Si Road, Nantong 226001, People's Republic of China; Insitute of Public Health, Nantong University, 9 Se Yuan Road, Nantong 226001, People's Republic of China. Electronic address:

Atherosclerosis is a chronic inflammatory disease with lipid accumulation. Apolipoprotein C3 (APOC3), which is an important regulator of human lipid metabolism, is associated with multiple vascular mechanisms in atherosclerosis and proinflammatory responses. We have previously reported that the expression of inflammatory cytokine TNF-α is elevated in human endothelial cells (HUVECs) after APOC3 treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183031
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http://dx.doi.org/10.1016/j.carpath.2019.02.005DOI Listing
March 2019
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Microelements in seminal and serum plasma are associated with fresh semen quality in Yorkshire boars.

Theriogenology 2019 Apr 6;132:88-94. Epub 2019 Apr 6.

Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, PR China. Electronic address:

This study aimed to explore associations between semen quality and trace element level in serum and seminal plasma in Yorkshire boars. Semen quality of 112 Yorkshire boars was assessed for 13 weeks to calculate semen utilization rate, which was then divided into three categories: low utilization rate group (LG, < 60% utilization rate), medium utilization rate group (MG, 60-80%), and high utilization rate group (HG, > 80%). After grouping, serum and seminal plasma samples of selected boars were collected to determine concentrations of 10 elements including Ca, Mg, Cu, Fe, Zn, Mn, Se, Cr, Pb and Cd using inductively coupled plasma mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.04.002DOI Listing

Extent and Determinants of Terminally Ill Cancer Patients' Concordance between Preferred and Received Life-Sustaining Treatment States: An Advance Care Planning Randomized Trial in Taiwan.

J Pain Symptom Manage 2019 Apr 17. Epub 2019 Apr 17.

Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taiwan; Department of Nursing, Chang Gung Memorial Hospital at Kaohsiung, Taiwan. Electronic address:

Purpose: To examine the effectiveness of an advance care planning (ACP) intervention in facilitating concordance between cancer patients' preferred and received life-sustaining treatment (LST) states and to explore modifiable factors facilitating or impeding such concordance.

Methods: Terminal cancer patients (N=460) were randomly assigned 1:1 to the experimental and control arms of a randomized clinical trial, with 430 deceased participants comprising the final sample. States of preferred LSTs (cardiopulmonary resuscitation, intensive care unit care, chest compression, intubation with mechanical ventilation, intravenous nutrition, and nasogastric tube feeding) and LSTs received in the last month were examined by hidden Markov modeling. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.04.010DOI Listing
April 2019
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Letter to The Editor - Referring to the published article - Topical Steroids Alters Disease Course Over a 5-Year Follow-up Period in Adult Patients.

Authors:
Noam Zevit

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Institute of Gastroenterology, Nutrition, and Liver Diseases; Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.04.028DOI Listing

Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions.

Biotechnol Adv 2019 Apr 17. Epub 2019 Apr 17.

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau. Electronic address:

The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.007DOI Listing

Strength of association between pentosan polysulfate and a novel maculopathy.

Ophthalmology 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322. Electronic address:

In this retrospective study of 219 patients with interstitial cystitis at a single institution, pentosan polysulfate exposure was the sole predictor of a newly described maculopathy. All 14 affected patients had exposure to the drug. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.04.024DOI Listing
April 2019
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Monosaccharide composition influence and immunomodulatory effects of probiotic exopolysaccharides.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Department of Food Science and Nutrition, Meiho University, Taiwan. Electronic address:

Exopolysaccharides (EPSs) are metabolites of probiotics that have gained wide interest recently. A strain of Lactobacillus reuteri Mh-001 with high exopolysaccharide (EPS) production ability was isolated, identified, and were used to investigate the anti-inflammatory effects of the EPSs. Among the three unpurified EPSs, RAW246. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.109DOI Listing

Maternal Triacylglycerol Signature and Offspring Risk of Food Allergy.

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA; Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Background: The prevalence of IgE-mediated food allergy (FA) is rising worldwide but the underlying mechanisms are poorly understood.

Objective: To examine the role of maternal lipidomic profiles in offspring risk of FA development; and to investigate the potential modification effects by timing of first solid food introduction.

Methods: This report included 1,068 mother-child dyads from the Boston Birth Cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193052
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http://dx.doi.org/10.1016/j.jaci.2019.03.033DOI Listing
April 2019
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Ferric citrate, nitrate, saponin, and their combinations affect in-vitro ruminal fermentation, production of sulfide and methane, and abundance of select microbial populations.

J Appl Microbiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Animal Sciences, The Ohio State University, Columbus, Ohio, 43210-1094, USA.

Aims: This study investigated the effects of ferric citrate, nitrate, and saponin, both individually and in combination, on sulfidogenesis, methanogenesis, rumen fermentation, and abundances of select microbial populations using in vitro rumen cultures.

Methods And Results: Ferric citrate (50 mg L ), Quillaja saponin (0·6 g L ), and sodium nitrate (5 mmol L ) were used in in vitro ruminal fermentation. Ferric citrate alone, its combination with saponin and/or nitrate lowered the aqueous sulfide concentration and total sulfide production. Read More

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http://dx.doi.org/10.1111/jam.14286DOI Listing

Qualitative analysis of the vocabulary used in work logs of a preventive program for elderly oral function and nutrition.

J Oral Rehabil 2019 Apr 20. Epub 2019 Apr 20.

Oral Rehabilitation, Niigata University Medical and Dental Hospital.

Background: In Japan, daycare services for elders include programs aimed at improving nutrition and oral and motor functions. Few studies have qualitatively assessed these interventions.

Objective: To qualitatively search for the characteristic words used in the work logs of a preventive program on oral function and nutrition for elders by intervention period and intervention type. Read More

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http://dx.doi.org/10.1111/joor.12804DOI Listing

Nisin incorporation enhances the inactivation of lactic acid bacteria during the acid wash step of bioethanol production from sugarcane juice.

Lett Appl Microbiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Food Science & Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Bioethanol fermentation is continuously exposed to contamination by Lactic Acid Bacteria (LAB). In the present study, the effect of adding nisin (250 mg L ) to the acid wash on the viability of five bacterial contaminants were evaluated both alone and in co-incubation with Saccharomyces cerevisiae. Additionally, fed-batch fermentation was performed using an acid or acid/nisin wash for S. Read More

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http://dx.doi.org/10.1111/lam.13165DOI Listing

Spinal cord-level adaptations to resistance training: the 'backbone' of early strength gains?

J Physiol 2019 Apr 20. Epub 2019 Apr 20.

Institute of Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC, 3125.

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http://dx.doi.org/10.1113/JP277893DOI Listing
April 2019
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