725,127 results match your criteria Nursing Home Acquired Pneumonia


Educational needs for new graduate nurses in Korea.

Nurse Educ Pract 2018 Dec 5;34:167-172. Epub 2018 Dec 5.

College of Nursing, Ewha Womans University, Hellen hall, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, South Korea. Electronic address:

New nursing graduates often experience difficulty adjusting to clinical work environments, despite completing well-structured education programs. This study explored the educational needs of recent nursing graduates from the perspectives of new nurses and their clinical educators in Korea. Four focus-group interviews with 7 nurse educators and 8 new nurses were conducted. Read More

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December 2018

The state of bereavement support in adult intensive care: A systematic review and narrative synthesis.

J Crit Care 2018 Dec 1;50:177-187. Epub 2018 Dec 1.

University of Ottawa, Faculty of Health Sciences, School of Nursing, 3245B Roger Guindon Hall, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada. Electronic address:

Purpose: Despite advances in medical science, patient death and family bereavement are commonly encountered in adult intensive care units (ICUs). This is the first review to investigate the state of ICU bereavement support globally, and the availability and effectiveness of bereavement support interventions.

Methods: A systematic review and narrative synthesis. Read More

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December 2018
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Changes in the Rates and Population Structure of MRSA from bloodstream infections. A Single Center Experience (2000-2015).

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

First Department of Medicine, "Laikon" General Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece. Electronic address:

Objectives: We aimed to assess the MRSA Bloodstream Infection (BSI) rates and the population structure of the MRSA isolates recovered between 2000 and 2015 in a tertiary care hospital in Athens, Greece.

Methods: Non-repetitive MRSA blood isolates recovered during the study period were examined. Antimicrobial susceptibility testing was performed by Kirby-Bauer and the gradient strip methods Carriage of the PVL and mecA genes were examined by PCR. Read More

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December 2018

Pet robot intervention for people with dementia: A systematic review and meta-analysis of randomized controlled trials.

Psychiatry Res 2018 Dec 6;271:516-525. Epub 2018 Dec 6.

School of Nursing, Jilin University, Changchun, China; Department of Pharmacology, college of Basic Medical sciences, Jilin University, Changchun, China. Electronic address:

This study aims to systematically evaluate the efficacy of Pet robot intervention (PRI) for people with dementia. Two waves of electronic searches of the PubMed, EMBASE, Web of Science, Cochrane library, IEEE Digital Library and PsycINFO databases were conducted. In total, eight articles from six randomized controlled trials (RCTs) met the eligibility criteria and were included in this systematic review. Read More

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December 2018

The experience of Person-centred Practice in a 100% single-room environment in acute care settings - a narrative literature review.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

Nursing Research and Practice Development, Ulster University, and South Eastern Health and Social Care Trust, Northern Ireland.

Aims And Objectives: To review published research into the staff and adult patient experience of person-centred practice in a 100% single-room environment in acute care.

Background: There has been a significant move towards the 100% single-room environment within healthcare systems. Furthermore, there has been a global move for developing person-centred practice in a range of healthcare settings. Read More

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December 2018
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Caring by Telecare? A Hermeneutic Study of Experiences among Older Adults and Their Family Caregivers.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

Department of Health and Nursing Sciences, University of Agder, Norway.

Aims And Objectives: The purpose of this study was to obtain a deeper understanding of the persistent use of telecare for older adults and their family caregivers.

Background: Telecare is seen as part of the solution in home care services for ageing in place. Previous studies have shown that telecare is a complex intervention, and there is still a poor understanding of older adults' and their family caregivers' experience with the use of telecare. Read More

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December 2018

Nurses' descriptions of person-centred care for older people in an acute medical ward - on the individual, team and organizational levels'.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

School of Nursing and Midwifery l College of Science, Health and Engineering, Latrobe University Melbourne, Victoria, Australia, 3086.

Aim And Objectives: To describe nurses' experiences of providing person-centred care (PCC) for older people on an acute medical ward.

Background: There is evidence that PCC for older people contributes to a higher quality care and increased satisfaction with care. However there is a shortness of studies providing concrete examples of what facilitates nurses providing PCC for older people in acute care. Read More

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December 2018

How Do Family Strengths-Oriented Therapeutic Conversations (FAM-SOTC) Advance Psychiatric Nursing Practice?

J Nurs Scholarsh 2018 Dec 15. Epub 2018 Dec 15.

Psychiatric Clinical Nurse Specialist, Landspitali University Hospital, Landspitali-The National University Hospital in Iceland, Child and Adolescent Psychiatric Division, Reykjavik, Iceland.

Purpose: Family nursing interventions, focusing on therapeutic conversations, have been found to benefit primary caregivers dealing with chronic and acute illnesses. Less is known, however, about the benefit of these interventions for partner caregivers. The aims of this study were to develop and test the Family Strengths-Oriented Therapeutic Conversation (FAM-SOTC) intervention for partner caregivers of young individuals with eating disorders (EDs). Read More

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December 2018
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Unit Leadership and Climates for Evidence-Based Practice Implementation in Acute Care: A Cross-Sectional Descriptive Study.

J Nurs Scholarsh 2018 Dec 15. Epub 2018 Dec 15.

Rho, Professor, University of Michigan School of Nursing, Ann Arbor, MI, USA.

Purpose: The purposes of this study were to (a) describe nurse manager (NM) leadership behaviors for evidence-based practice, NM evidence-based practice competencies, and unit climates for evidence-based practice implementation in acute care, and (b) test for differences in NMs' and staff nurses' (RNs') perceptions.

Design: A multisite cross-sectional design was used to collect data from a sample of 24 NMs and 553 RNs from 24 adult medical-surgical units in seven U.S. Read More

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December 2018

Patients' experiences and perspectives of challenges and needs related to non-myeloablative stem cell transplantation: involving patients in developing a targeted rehabilitation programme.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Public Health, Section for Clinical Social Medicine and Rehabilitation, Faculty of Health, Aarhus University, Denmark.

Aims And Objectives: To explore patients' experiences and perspectives of their challenges and needs regarding their return to everyday life after allogeneic non-myeloablative haematopoietic stem cell transplantation (NMA-HSCT).

Background: NMA-HSCT can cure patients with malignant blood diseases, but during the following years the majority of patients suffer from serious side effects and complications. Hence, it is a major challenge for patients treated with NMA-HSCT to rehabilitate, maintain physical and psychosocial functioning and return to a life in restored balance. Read More

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December 2018
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RS7435335 located in the UGT2B7 gene may be a possible genetic marker for the clinical response and prognosis of breast cancer patients receiving neoadjuvant chemotherapy.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Nursing, Rizhao LanShan of People's Hospital, Rizhao, Shandong, China.

Objective: To evaluate the predictive efficacy and prognostic value of rs7435335 located in the UGT2B7 gene as a genetic marker in breast cancer patients receiving neoadjuvant chemotherapy (NAC).

Methods: A total of 190 patients with breast cancer treated with NAC were enrolled to detect the rs7435335 SNP by sequenom. Miller-Payne grades were used to evaluate the treatment efficacy. Read More

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December 2018

CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

Cancer stem cells (CSCs) exist in colon cancer and exhibit characteristics of stem cells which are due to lineages of tissues where they arise. Epithelial to mesenchymal transition (EMT)-undergoing cancer cells display CSC properties and therapeutic resistance. Cancer and stromal cells comprise of a tumor microenvironment. Read More

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December 2018

Healthcare service utilization and work-related productivity in reflexology intervention for advanced breast cancer women.

Support Care Cancer 2018 Dec 14. Epub 2018 Dec 14.

College of Nursing, Michigan State University, East Lansing, MI, 48824, USA.

Purpose: This project's purpose was to determine the effects of a home-based reflexology intervention on symptom-related use of health services and work-related productivity during the 11-week study.

Methods: A total of 256 patients were randomized to four weekly reflexology sessions (each lasting 30 min, delivered by lay caregivers who received two training sessions by a professional reflexologist) or attention control. The Conventional Health Service and Productivity Costs Form was used to collect information on health service utilization and out-of-pocket expenditure of symptom management. Read More

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December 2018

[Prospects and constraints of nursing home-based integrated adult day care : Viewpoints of experts].

Z Gerontol Geriatr 2018 Dec 14. Epub 2018 Dec 14.

AG6 Versorgungsforschung & Pflegewissenschaft, Fakultät für Gesundheitswissenschaften, Universität Bielefeld, Universitätsstraße 25, 33615, Bielefeld, Deutschland.

Background: Even when they are in need of care, old people prefer to stay in their community. An appropriate design of nonresidential and residential care services close to people's home is crucial for supporting them. In the model project "Pflege stationär-Weiterdenken!" (Nursing home care-think ahead!) nursing homes offer extended services to old people in the community. Read More

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December 2018

Effectiveness of self-testing kits availability on improving HIV testing frequency for chinese men who have sex with men and their sexual partners: a protocol for a multicenter randomised controlled trial.

BMJ Open 2018 Dec 14;8(12):e024423. Epub 2018 Dec 14.

Xiangya Nursing School of Central South University, Changsha, China.

Introduction: HIV epidemic is increasing among men who have sex with men (MSM) in China, yet HIV testing uptake remains low. As an emerging approach, HIV self-testing (HIVST) has the potential to promote HIV testing coverage and frequency in this population. However, evidence of the effectiveness on implementation of HIVST among Chinese MSM and their sexual partners is scarce. Read More

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December 2018

Prognostic value of Modified Early Warning Score generated in a Chinese emergency department: a prospective cohort study.

BMJ Open 2018 Dec 14;8(12):e024120. Epub 2018 Dec 14.

Research Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Objectives: This study aimed to validate the performance of the Modified Early Warning Score (MEWS) in a Chinese emergency department and to determine the best cut-off value for in-hospital mortality prediction.

Design: A prospective, single-centred observational cohort study.

Setting: This study was conducted at a tertiary hospital in South China. Read More

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December 2018

Vascular and cognitive effects of cocoa-rich chocolate in postmenopausal women: a study protocol for a randomised clinical trial.

BMJ Open 2018 Dec 14;8(12):e024095. Epub 2018 Dec 14.

Primary Health Care Research Unit, La Alamedilla Health Center, Institute of Biomedical Research of Salamanca (IBSAL), Health Service of Castilla y León (SACyL), Salamanca, Spain.

Introduction: The intake of polyphenols has certain health benefits. This study will aim to assess the effect of adding a daily amount of chocolate high in cocoa content and polyphenols to the normal diet on blood pressure, vascular function, cognitive performance, quality of life and body composition in postmenopausal women.

Methods And Analysis: Here we plan a randomised clinical trial with two parallel groups involving a total of 140 women between 50 and 64 years in the postmenopausal period, defined by amenorrhoea of ​​at least 12 consecutive months. Read More

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December 2018

Study protocol for a randomised controlled trial of humanoid robot-based distraction for venipuncture pain in children.

BMJ Open 2018 Dec 14;8(12):e023366. Epub 2018 Dec 14.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Introduction: Intravenous insertion (IVI) is a very common procedure in the emergency department (ED). IVI is often painful and stressful for both children and their families. Currently, distraction therapy is not used as a standard of care for IVI in North America. Read More

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December 2018

Impact of workplace incivility in hospitals on the work ability, career expectations and job performance of Chinese nurses: a cross-sectional survey.

BMJ Open 2018 Dec 14;8(12):e021874. Epub 2018 Dec 14.

Department of Health Management, School of Public Health, Harbin Medical University, Harbin, China.

Objectives: The objectives of this study were to investigate new nurses' experiences of workplace incivility; verify the mediating role of work ability in the relationship between workplace incivility and job performance and examine the moderating role of career expectations in the relationship between workplace incivility and job performance.

Design: This cross-sectional survey was conducted in China in May 2016.

Settings: The research settings included 54 cities across 29 provinces of China. Read More

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December 2018

A genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in on Chromosome 12q13.13 Associated with Susceptibility to Fulminant Type 1 Diabetes.

Diabetes 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka, Japan

The first genome-wide association study of fulminant type 1 diabetes mellitus was performed in Japanese individuals. As previously reported using a candidate gene approach, a strong association was observed with multiple SNPs in the HLA region, and the strongest association was observed with rs9268853 in the class II DR region (P=1.56 x 10, odds ratio [OR] 3. Read More

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December 2018
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Home use of breast milk fortifier to promote postdischarge growth and breast feeding in preterm infants: a quality improvement project.

Arch Dis Child 2018 Dec 14. Epub 2018 Dec 14.

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK.

To improve the postdischarge growth of exclusively breastfed preterm infants, born weighing ≤1.8 kg, by using breast milk fortifier (BMF) supplements postdischarge until 48 weeks' gestational age. A quality improvement (QI) project involving plan-do-study-act (PDSA) cycles. Read More

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December 2018

Predicting Prediabetes Through Facebook Postings: Protocol for a Mixed-Methods Study.

JMIR Res Protoc 2018 Dec 14;7(12):e10720. Epub 2018 Dec 14.

David Eccles School of Business, University of Utah, Salt Lake City, UT, United States.

Background: The field of infodemiology uses health care trends found in public networks, such as social media, to track and quantify the spread of disease. Type 2 diabetes is on the rise worldwide, and social media may be useful in identifying prediabetes through behavior exhibited through social media platforms such as Facebook and thus in designing and administering early interventions and containing further progression of the disease.

Objective: This pilot study is designed to investigate the social media behavior of individuals with prediabetes, before and after diagnosis. Read More

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December 2018

Redesigning primary care in the safety net: A qualitative analysis of team-based care implementation.

Healthc (Amst) 2018 Dec 11. Epub 2018 Dec 11.

University of California San Francisco, Center for Vulnerable Populations, Division of General Internal Medicine, United States.

Background: Team-based care is an innovative approach to primary care in which groups of health care professionals work collaboratively to manage care for groups of patients. Safety-net organizations face specific barriers to implementing health care innovations. More research is needed that documents the dynamics that inform implementation and sustainment of innovative practices in the safety net. Read More

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December 2018

Oral mucosa pressure ulcers in intensive care unit patients: A preliminary observational study of incidence and risk factors.

J Tissue Viability 2018 Dec 5. Epub 2018 Dec 5.

Urology Ward, Pusan National University Hospital, Busan, South Korea.

Purpose: This study examined the incidence of oral mucosa pressure ulcers (PUs) in intensive care unit (ICU) patients and the relationship between biomechanical and physiological variables in onset of PUs.

Methods: A prospective observational descriptive study design was used. We recruited patients over 18 years of age with endotracheal tube (ETT) insertion in three ICUs in a tertiary hospital in Korea. Read More

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December 2018
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Pro Re Nata Drug Use in Nursing Home Residents: A Systematic Review.

J Am Med Dir Assoc 2018 Dec 11. Epub 2018 Dec 11.

Carl von Ossietzky University Oldenburg, Department of Health Services Research, Oldenburg, Germany.

Objectives: In addition to routinely administered long-term medication, complex drug regimens of nursing home residents often include as needed or pro re nata (PRN) medication. However, there has been no systematic evaluation of the frequency and concomitants of PRN medication in nursing homes. The main objective of this systematic review was to provide a current assessment of PRN drug use in nursing homes. Read More

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December 2018

STOP-FALLING: A Simple Checklist Tool for Fall Prevention in a Nursing Facility.

J Am Med Dir Assoc 2018 Dec 11. Epub 2018 Dec 11.

Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Hebrew Senior Life, Institute for Aging Research, Boston, MA.

Falls are highly prevalent and lead to major health morbidity and mortality in older adults. We developed a "STOP-FALLING" checklist as a multifactorial intervention tool kit for a single long-term care facility. The objective of this study was to determine feasibility and adherence of the checklist, and to determine whether STOP-FALLING reduces total number of falls, frequent fallers, and fall-related injuries. Read More

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December 2018

A nurse-driven method for developing artificial intelligence in "smart" homes for aging-in-place.

Nurs Outlook 2018 Nov 23. Epub 2018 Nov 23.

School of Nursing & Midwifery, Edith Cowan University, Joondalup Campus, Perth, Australia.

Objectives: To offer practical guidance to nurse investigators interested in multidisciplinary research that includes assisting in the development of artificial intelligence (AI) algorithms for "smart" health management and aging-in-place.

Methods: Ten health-assistive Smart Homes were deployed to chronically ill older adults from 2015 to 2018. Data were collected using five sensor types (infrared motion, contact, light, temperature, and humidity). Read More

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November 2018

Evaluation of a Practice Improvement Protocol for Patient Transfer From the Emergency Department to the Surgical Intensive Care Unit After a Level I Trauma Activation.

J Emerg Nurs 2018 Dec 11. Epub 2018 Dec 11.

Background: ED boarding is a major issue in many hospitals. ED boarding occurs when there is insufficient hospital capacity to supply inpatient beds for admitted patients. ED boarding is not only a problem because of increased wait times for patients but also because it results in delays in administration of medication, higher rates of complications, and increased mortality. Read More

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December 2018
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[A place for intimacy and sexuality in nursing homes].

Soins 2018 Dec;63(831):48-51

c/o Soins, Elsevier Masson SAS, 65, rue Camille-Desmoulins, 92442 Issy-les-Moulineaux, France. Electronic address:

In nursing homes, intimacy is threatened by the increased dependence and lack of support. It is nevertheless possible to preserve it, meaning it is possible to ensure a continuity of existence for the elderly person in an institution. Read More

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December 2018

[Caregivers faced with intimacy and sexuality].

Authors:
Alain Giami

Soins 2018 Dec;63(831):44-47

CESP, Inserm U1018, équipe 7, Université Paris-Saclay, Hôpital Paul-Brousse, Bâtiment 15/16, 16, avenue Paul Vaillant-Couturier, 94807 Villejuif cedex, France. Electronic address:

Caregivers are confronted with the eroticisation of the care relationship due to the direct physical and close contact with patients and access to their private area. Through lack of training, caregivers often draw on their own personal resources to respond in a suitable and professional manner in these situations. Read More

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December 2018

[Pace of care and wellbeing at work, exploratory study].

Soins 2018 Dec;63(831):27-29

Médecine psychologique pour enfants et adolescents, hospitalisation complète, HDJ, Hôpital Saint-Eloi, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France. Electronic address:

The economic models developed in health policies force hospitals to make decisions with regard to the reorganisation of work. These have impacts on nursing competences and ergonomics in particular. A study analysing a situation of ten minutes of nursing work highlighted the work pace as well as the mental, emotional and physical strains put upon the professional. Read More

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December 2018

Prevalence, awareness, control and determinants of hypertension among primary health care professional nurses in Eastern Cape, South Africa.

Afr J Prim Health Care Fam Med 2018 Nov 22;10(1):e1-e5. Epub 2018 Nov 22.

Department of Nursing Science, Faculty of Health Sciences, University of Fort Hare.

Background:  Nurses in primary health care settings are key stakeholders in the diagnosis and management of hypertensive patients. Unfortunately, the working conditions of nurses predispose them to stress, long hours of work, shift duties and unhealthy diets, which are drivers of hypertension. Yet nurses are often overlooked in health screening exercises, primarily because they are assumed to be informed and 'healthy'. Read More

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November 2018

Academic monitoring and support of undergraduate nursing education programme: A middle-range theory.

Curationis 2018 Dec 3;41(1):e1-e11. Epub 2018 Dec 3.

School of Nursing and Public Health, University of KwaZulu-Natal.

Background:  Globally, there is consensus on the need for student support to address high student attrition and low throughputs, especially in nursing and midwifery programmes.

Objectives:  This study analysed the implementation of academic monitoring and support (AMS) in an undergraduate nursing programme to generate a context-informed academic monitoring and support middle-range theory.

Method:  An ethnographic design and grounded theory approach were adopted in this study. Read More

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December 2018
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The effects of absenteeism on nurses remaining on duty at a tertiary hospital of Limpopo province.

Curationis 2018 Nov 27;41(1):e1-e5. Epub 2018 Nov 27.

Department of Nursing Science, University of Limpopo.

Background:  Absenteeism is a global problem in the working force and this is no exception in the nursing profession. Much attention has been drawn to factors that contribute to absenteeism; however, little attention has been placed on the effects of absenteeism on nurses remaining on duty by their colleagues. Nurses absent themselves leaving behind their colleagues to execute their part of work. Read More

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November 2018

Experimental Endometriosis: Review of the Literature Through a Century and the Iranian Experience.

Arch Iran Med 2018 Nov 1;21(11):536-543. Epub 2018 Nov 1.

Department of Nursing Science, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Although endometriosis is not a newly discovered disease, it has still remained enigmatic. Understanding the pathophysiology of this disease is still one of the challenges of gynecology and reproductive medicine. Therefore, the subject of endometriosis treatment faces many questions to be answered. Read More

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November 2018

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Department of Biochemistry, College of Medicine, Konyang University, 158, Gwanjeodong-ro, Seo-gu, Daejeon 35365, Korea.

Alzheimer's disease (AD) is a neurodegenerative disease, which is accompanied by memory loss and cognitive dysfunction. Although a number of trials to treat AD are in progress, there are no drugs available that inhibit the progression of AD. As the aggregation of amyloid-β (Aβ) peptides in the brain is considered to be the major pathology of AD, inhibition of Aβ aggregation could be an effective strategy for AD treatment. Read More

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December 2018
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Mobile App-Based Health Promotion Programs: A Systematic Review of the Literature.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

College of Nursing, Yonsei University, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.

This study investigated the features and usefulness of mobile app-based health promotion programs for the general population. A comprehensive bibliographic search of studies on health promotion programs using mobile apps in peer-reviewed journals published in English up to November 2017 was performed using the PubMed, Embase, and CINAHL databases. The inclusion criteria were (1) randomized control trial designs; (2) assessed mobile app-based interventions to promote adult health conditions; 12 studies were ultimately included. Read More

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December 2018

Pathophysiological mechanisms of diabetic cardiomyopathy and the therapeutic potential of epigallocatechin-3-gallate.

Biomed Pharmacother 2019 Jan 27;109:2155-2172. Epub 2018 Nov 27.

Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt. Electronic address:

Cardiovascular complications are considered one of the leading causes of morbidity and mortality among diabetic patients. Diabetic cardiomyopathy (DCM) is a type of cardiovascular damage presents in diabetic patients independent of the coexistence of ischemic heart disease or hypertension. It is characterized by impaired diastolic relaxation time, myocardial dilatation and hypertrophy and reduced systolic and diastolic functions of the left ventricle. Read More

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January 2019
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Memantine ameliorates pulmonary inflammation in a mice model of COPD induced by cigarette smoke combined with LPS.

Biomed Pharmacother 2019 Jan 26;109:2005-2013. Epub 2018 Nov 26.

Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China. Electronic address:

An enhanced chronic inflammatory response in the airways has been regarded as a critical characteristic of chronic obstructive pulmonary disease (COPD). Memantine, an N-methyl-d-aspartate (NMDA) receptors antagonist, has been reported to alleviate lung inflammation. In this study, we investigated the effect and mechanism of memantine on the COPD model induced by cigarette smoke (CS) combined with LPS. Read More

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January 2019

The blockade of lipophagy pathway is necessary for docosahexaenoic acid to regulate lipid droplet turnover in hepatic stellate cells.

Biomed Pharmacother 2019 Jan 26;109:1841-1850. Epub 2018 Nov 26.

College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:

Hepatic stellate cell (HSC) activation is treated as a dominator segment in hepatic fibrosis, which is accompanied by significant loss of lipid droplets (LDs). However, the regulatory network of LD disappearance is still unclear. It has been reported that lipophagy activation contributed to LD loss by upregulating RAB25 expression. Read More

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January 2019

Fibronectin promotes nasopharyngeal cancer cell motility and proliferation.

Biomed Pharmacother 2019 Jan 26;109:1772-1784. Epub 2018 Nov 26.

Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Nasopharyngeal cancer (NPC) is an Epstein-Barr virus (EBV)-associated carcinoma. Fibronectin is regarded as a prognosticator in NPC and its involvement in cell motility has been reported in EBV infection and viral latent membrane protein 1 (LMP1) overexpression NPC cell lines. However, its malignant potential in NPC cell lines without harbouring the EBV genome has not been investigated. Read More

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January 2019

Loneliness and social isolation of military veterans: systematic narrative review.

Occup Med (Lond) 2018 Dec 14. Epub 2018 Dec 14.

Faculty of Health and Life Sciences, Department of Nursing, Midwifery and Health, Northern Hub for Veterans and Military Families' Research, Northumbria University, Newcastle-upon-Tyne, UK.

Background: Loneliness and social isolation are being increasingly recognized as influencing both physical and mental health. There is limited research carried out with military veterans and, to date, there is no review of existing evidence.

Aims: To synthesize and examine the evidence exploring aspects of social isolation and loneliness of military veterans, using a systematic narrative review strategy. Read More

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December 2018

The antecedents of loneliness in older people with an intellectual disability.

Res Dev Disabil 2018 Dec 11;85:116-130. Epub 2018 Dec 11.

School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland.

Introduction: The cognitive discrepancy approach to loneliness is often used to describe loneliness in ageing populations, but to date, it has never been used to explore loneliness in older people with an intellectual disability. An analysis is needed utilising a refined list of causes of loneliness in this population.

Method: Using data from a nationally representative dataset of people aged over 40 with an intellectual disability (N = 708), this analysis runs repeated regressions of variables grouped into conceptual blocks, organised from sociodemographic to network quality. Read More

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December 2018

Mobilising evidence to improve nursing practice: A qualitative study of leadership roles and processes in four countries.

Int J Nurs Stud 2018 Nov 27;90:21-30. Epub 2018 Nov 27.

School of Education, Health, and Social Studies, Dalarna University, Falun, Sweden.

Background: The approach and style of leaders is known to be an important factor influencing the translation of research evidence into nursing practice. However, questions remain as to what types of roles are most effective and the specific mechanisms through which influence is achieved.

Objectives: The aim of the study was to enhance understanding of the mechanisms by which key nursing roles lead the implementation of evidence-based practice across different care settings and countries and the contextual factors that influence them. Read More

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November 2018
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Piloting a practice model in a Norwegian nursing home- A student-managed ward: A way to empower students for the nursing role.

Nurse Educ Pract 2018 Nov 29;34:161-166. Epub 2018 Nov 29.

Department of Nursing and Health Promotion, OsloMet - Oslo Metropolitan University, Norway; Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.

This paper focuses on the experiences of nursing students on a student-managed ward, the purpose of which was to empower students for the nursing role. Five nursing students operated and managed a nursing home ward for eight weeks during their final year of nursing education. The students claimed that a group of five students was beneficial. Read More

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November 2018

National survey: Developing a common approach to grading of practice in pre-registration midwifery.

Nurse Educ Pract 2018 Nov 26;34:150-160. Epub 2018 Nov 26.

University College London, Gower St, Bloomsbury, London, WC1E 6BT, United Kingdom. Electronic address:

This paper presents the final phase of a national project exploring grading of practice in programmes leading to registration as a midwife in the United Kingdom. The aim was to develop a generic framework for grading practice, enhancing standardisation while enabling flexibility in application of current and new educational standards. A mixed method on-line survey considered existing practice assessment tools, factors contributing to robust and reliable assessment and perceptions of two assessment tools developed by the research team: a 'Lexicon Framework' and 'Rubric', which were tested through scenarios. Read More

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November 2018

Attentional bias modification reduces clinical depression and enhances attention toward happiness.

J Psychiatr Res 2018 Dec 1;109:145-155. Epub 2018 Dec 1.

Department of Psychology, The Third Military Medical University, Chongqing, 400038, China.

Difficulty in clinical antidepressant treatment leads to the pursuit of alternative treatments, such as cognitive-behavior therapy (CBT). CBT combined with regular antidepressants have indicated an optimal therapeutic effect in clinic. Attentional bias is important in the occurrence and remission of depression, however, few studies have explored the effect of attentional bias modification (ABM) on depression, and inconsistent results have been obtained due to the heterogeneity in the targeted populations, training tasks, strategies, and materials. Read More

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December 2018

Effect of education using the virtual social network on the knowledge and attitude of emergency nurses of disaster preparedness: A quasi-experiment study.

Nurse Educ Today 2018 Dec 6;73:88-93. Epub 2018 Dec 6.

School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Nurses play an important role in helping people to cope with disasters. Dealing with disasters requires proper knowledge, attitudes and skills that can be achieved through education. Education through virtual social networks as a method of distance education can be used due to its accessibility and ease of use. Read More

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December 2018
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