379 results match your criteria Nummular Dermatitis


[Corneal deposits in monoclonal gammopathy of undetermined significance. Review of the literature and case report].

Orv Hetil 2018 Sep;159(39):1575-1583

Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.

To summarize ophthalmological signs of monoclonal gammopathy of undetermined significance (MGUS) and to present a case report. Summary of the literature data and presentation of the history of a 46-year-old female patient. In MGUS, pathological, but non-malignant plasma cells produce abnormal monoclonal immunoglobulin. Read More

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September 2018

Subacute cutaneous lupus erythematosus induced by nivolumab: two case reports and a literature review.

Melanoma Res 2018 Nov 26. Epub 2018 Nov 26.

Departments of Dermatology.

Nivolumab is widely used to treat several late-stage malignancies such as melanoma and non-small-cell lung cancer by inhibiting the interaction between the programmed cell death protein-1 and its ligand. By stimulating an antitumor immune response, it also leads to immune adverse events. Here. Read More

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November 2018
1 Read

Annular Lesions: Diagnosis and Treatment.

Am Fam Physician 2018 Sep;98(5):283-291

Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Annular lesions can present in a variety of diseases. Knowledge of the physical appearance and history of presentation of these skin findings can help in the diagnosis. A pruritic, annular, erythematous patch that grows centrifugally should prompt evaluation for tinea corporis. Read More

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September 2018
7 Reads

Hydroxyurea Associated Cutaneous Lesions: A Case Report.

Open Access Maced J Med Sci 2018 Aug 19;6(8):1458-1461. Epub 2018 Aug 19.

University Clinic for Dermatology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Hydroxyurea (HU) is an antimetabolite agent that interferes with the S-phase of cellular replication and inhibits DNA synthesis, with little or no effect on RNA or protein synthesis. It is used in the treatment of many myeloproliferative disorders (MD) and is particularly a first line treatment drug for intermediate to high-risk essential thrombocythemia. Although safe and very well tolerated by the patients suffering from MD, there have been numerous reports of a broad palette of cutaneous side effects associated with prolonged intake of the medication. Read More

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August 2018
8 Reads

Unusual Headache Disorders.

Continuum (Minneap Minn) 2018 Aug;24(4, Headache):1192-1208

Purpose Of Review: Unusual headache disorders are less commonly discussed and may be misdiagnosed. These headache disorders frequently have a benign natural history; however, without reassurance, therapeutic education, and treatment, they can negatively affect the health and function of patients.

Recent Findings: This article reviews the clinical features, diagnosis, workup, and proposed treatments for several unusual headache disorders including primary cough headache, primary headache associated with sexual activity, primary exercise headache, cold-stimulus headache, primary stabbing headache, nummular headache, hypnic headache, and headache attributed to travel in space. Read More

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August 2018
4 Reads

Nummular eczema of the breast following surgery and reconstruction in breast cancer patients.

Acta Oncol 2018 Nov 17;57(11):1586-1588. Epub 2018 Jul 17.

b Montefiore Medical Center, Department of Medicine, Division of Dermatology , Bronx , NY , USA.

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November 2018
7 Reads

Giraffe or leopard spot chorioretinopathy as an outstanding finding: case report and literature review.

Int Ophthalmol 2018 Jun 8. Epub 2018 Jun 8.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, No. 23, Paidarfard St., Pasdaran Ave., Tehran, 16666, Iran.

Purpose: Presentation of two typical cases with characteristic leopard retinopathy secondary to bilateral diffuse uveal melanocytic proliferation (BDUMP) and idiopathic uveal effusion syndrome (IUES) and brief review of the literature about leopard spot retinopathy.

Case Report: A 43-year-old women, who was a known case of ovarian carcinoma, referred with gradual bilateral visual loss. In ophthalmic examination, subretinal fluid, multiple patchy subretinal hyperpigmented lesions and leopard spot chorioretinopathy were evident in her both eyes. Read More

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June 2018
15 Reads

Methotrexate for severe nummular eczema in children: Efficacy and tolerability in a retrospective study of 28 patients.

Pediatr Dermatol 2018 Sep 26;35(5):611-615. Epub 2018 Jun 26.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Background/objectives: Nummular eczema in children is a chronic condition characterized by pruritic coin-shaped eczematous lesions that affect any part of the body and often become exudative. Mid- to high-potency topical corticosteroids are considered the mainstay treatment, but there are limited data on the use of systemic therapy for nummular eczema in children. The objective of the current study was to evaluate the efficacy and safety of methotrexate in children with severe nummular eczema. Read More

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September 2018
19 Reads
1.520 Impact Factor

Treatment of dopplerable nummular headache with minimally invasive arterectomy under local anesthesia.

J Plast Reconstr Aesthet Surg 2018 Jul 12;71(7):1010-1014. Epub 2018 Apr 12.

Department of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44195, USA.

Objective: The objective of the current study is to elucidate the potential role of surgery in the treatment of nummular headache (NH).

Background: NH is a disorder in which pain is localized to a specific area. Treatment has traditionally been medical, with the recent addition of nerve blocks and botox injection with equivocal results. Read More

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July 2018
1 Read

Mindfulness-Based Cognitive Hypnotherapy and Skin Disorders.

Am J Clin Hypn 2018 Jul;61(1):34-44

a University of South Florida , Tampa , FL, USA.

Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More

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July 2018
29 Reads

[A rare case of ocular scarrings in a patient with Vogt-Koyanagi-Harada disease].

Pan Afr Med J 2017 22;28:313. Epub 2017 Dec 22.

Université Mohamed V Souissi, Service d'Ophtalmologie A, Hôpital des Spécialités, CHU IBN Sina, Rabat, Maroc.

We here report the case of a 27-year old patient, followed-up in our Department for treatment of chronic Vogt-Koyanagi-Harada disease ( VKH disease). Fundus examination showed depigmentation of the retinal pigment epithelium and of the choroid, appearing as a pseudotumoral peripapillary lesion. Vogt-Koyanagi-Harada disease is a multisystem disorder, characterized by bilateral granulomatous panuveitis with serous exudative multifocal retinal detachment. Read More

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May 2018
5 Reads

[Nummular headache : Subcutaneous peripheral nerve field stimulation as an individual therapeutic attempt].

Schmerz 2018 04;32(2):121-127

Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

Background: Subcutaneous peripheral nerve field stimulation (sPNFS) is an established procedure for the treatment of chronic localized neuropathic pain of peripheral origin. The treatment of nummular headache primarily focuses on conservative methods with limited prospects of success. The role of sPNFS in the treatment of nummular headache has not been investigated as yet. Read More

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Reactivation of herpes simplex viral keratitis following the botulinum toxin injection.

Indian J Ophthalmol 2018 02;66(2):306-308

Jhaveri Microbiology Center, L V Prasad Eye Institute, Hyderabad, India.

We describe a case of 55-year-old male farmer presented with recurrent corneal abrasions with a spastic entropion in the left eye. Superior cornea showed typical nummular opacities suggestive resolved herpetic eye diseases. On further enquiry, he had similar episodes in the past. Read More

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February 2018
5 Reads

Pityriasis Rosea: Diagnosis and Treatment.

Am Fam Physician 2018 Jan;97(1):38-44

Emory University School of Medicine, Atlanta, GA, USA.

Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. Read More

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January 2018
4 Reads

Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center.

Ophthalmic Surg Lasers Imaging Retina 2018 Jan;49(1):70-75

In a prospective case series of patients with Blau-Jabs syndrome (BJS) conducted in the Ophthalmology Department/Federal University of Sao Paulo, seven patients with clinical and ophthalmologic manifestations of the disease and a positive genetic test result for the presence of a mutation in the CARD15/NOD2 gene were followed for a minimal period of 1 year. All patients had uveitis, five had nummular corneal subepithelial opacities, and four had multifocal choroiditis. Oral prednisolone was administered to all patients; inflammation was controlled in six patients with at least one immunosuppressive drug. Read More

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January 2018
2 Reads

The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review.

Clin Med Res 2017 Dec 11;15(3-4):75-87. Epub 2017 Dec 11.

Politeknik Kesehatan Jakarta, Indonesia.

Moisturizer is a major component of basic daily skin care, particularly in presence of epidermal barrier alteration and reduced epidermal water content. It is an important part of a dermatologist's strategy to maintain skin health as well as treating various dermatoses which co-exist with skin dryness and are linked to impaired skin barrier function, such as in atopic disorders as well as other types of dermatitis. Mastering the knowledge regarding mechanism of action, application, dosage, adverse effects as well as specific clinical usage of moisturizers is a must for a dermatologist in order to support their use, particularly for evidence-based, therapeutic purposes. Read More

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December 2017
7 Reads

IDIOPATHIC MULTIFOCAL CHOROIDITIS PRESENTING WITH A TRANSIENT PERIPAPILLARY WHITE RING.

Retin Cases Brief Rep 2018 Fall;12 Suppl 1:S81-S86

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.

Purpose: We describe with multimodal imaging the presentation and follow-up for a patient with idiopathic multifocal choroiditis and a transient peripapillary white ring.

Methods: Case report.

Results: A 39-year-old Asian woman was initially seen for an evaluation of lattice degeneration in 2015. Read More

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October 2018
3 Reads

Evidence of and experience with the use of onabotulinumtoxinA in trigeminal neuralgia and primary headaches other than chronic migraine.

Neurologia 2017 Nov 20. Epub 2017 Nov 20.

Unidad de Cefalea, Servicio de Neurología, Hospital Universitari Vall d'Hebron, Barcelona, España; Grupo de Investigación en Cefalea; VHIR, Universitat Autònoma de Barcelona, Barcelona, España.

Introduction: In the field of headaches, onabotulinumtoxinA (onabotA) is well established as a treatment for chronic migraine (CM). In recent years, it has been used increasingly to treat other primary headaches (high-frequency episodic migraine, trigeminal-autonomic cephalalgias, nummular headache) and trigeminal neuralgia. As this treatment will progressively be incorporated in the management of these patients, we consider it necessary to reflect, with a fundamentally practical approach, on the possible indications of onabotA, beyond CM, as well as its administration protocol, which will differ according to the type of headache and/or neuralgia. Read More

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November 2017
15 Reads

Nummular headache: an update and future prospects.

Expert Rev Neurother 2018 Jan 9;18(1):9-19. Epub 2017 Nov 9.

d Department of Neurology , Hospital Clínico Universitario de Valladolid , Valladolid , Spain.

Introduction: Nummular headache (NH) is characterized by continuous or intermittent head pain, which remains confined to a round or oval shaped area of the scalp, generally 1 to 6 cm in diameter. Usually mild or moderate in intensity, some patients suffer severe acute exacerbations or continuous disabling pain. Areas covered: This article reviews epidemiological and clinical features of NH, the most recently proposed pathophysiological mechanisms, and state-of-the-art management according to the literature. Read More

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January 2018
6 Reads

Stings of the Ant Wasmannia auropunctata (Hymenoptera: Formicidae) as Cause of Punctate Corneal Lesions in Humans and Other Animals.

J Med Entomol 2017 Nov;54(6):1783-1785

Wilkes Honors College, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL 33458.

Numerous researchers have observed a form of punctate corneal lesions causing leukomas (corneal opacities) in humans, domestic animals, and wild animals in different parts of the world. This condition has been reported under different names, including West Indian (or Caribbean) punctate keratopathy, West Indian dots, tropical punctate keratopathy, Rice's keratopathy, Florida keratopathy, and Florida spots. Many of these cases, appear to have a common cause, the stings of a small red ant, Wasmannia auropunctata (Hymenoptera: Formicidae), originally from the Neotropics, but spread to other parts of the world through human commerce. Read More

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November 2017
17 Reads

Typical and atypical clinical appearance of atopic dermatitis.

Clin Dermatol 2017 Jul - Aug;35(4):354-359. Epub 2017 Mar 24.

Icahn School of Medicine at Mt Sinai, New York, NY. Electronic address:

Atopic dermatitis is a complex, systemic inflammatory disorder associated with a variety of clinical features. The original criteria of Hanifin and Rajka include major criteria and a list of about two dozen minor criteria however, even the minor criteria do not include some features of atopic dermatitis noted less commonly but still seen with some frequency. This contribution first reviews the common clinical appearance of atopic dermatitis in infancy, childhood, and adulthood, as well as the less typical appearances, including lichenoid atopic dermatitis; juvenile plantar dermatosis; nummular-type atopic dermatitis; follicular atopic dermatitis; alopecia of atopic dermatitis; eczema coxsackium; and psoriasiform, perineal, and lip licker's dermatitis. Read More

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November 2017
10 Reads

Chemical Tattoo Treatment Leading to Systemic Cobalt Hypersensitivity.

Skinmed 2017 1;15(3):221-222. Epub 2017 Jun 1.

Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI;

An otherwise healthy 36-year-old Caucasian woman, without prior history of atopic dermatitis or eczema, presented to an outside dermatologist with a generalized, severely pruritic eruption involving the entire body except the face. One month previously, she had used a 50% trichloroacetic acid tattoo removal solution on a blue-colored tattoo on the medial aspect of the left ankle. The patient's eruption persisted for 7 months, and after several attempts to slowly taper her prednisone dose, she presented to our institution. Read More

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June 2017
13 Reads

Adult-Onset Atopic Dermatitis: Fact or Fancy?

Authors:
Jon M Hanifin

Dermatol Clin 2017 Jul;35(3):299-302

Department of Dermatology, Oregon Health & Science University, 3303 Bond Avenue, Portland, OR 97239, USA. Electronic address:

Atopic dermatitis therapy can be a challenge in many cases. Persistence into adulthood often reflects the more severe cases and such patients have the added problems of hand eczema and thick nummular lesions that resist topical medications. Within this group are patients labeled as having adult-onset atopic dermatitis, a designation that is hard to define and probably represents those whose childhood eczema was simply forgotten. Read More

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July 2017
22 Reads

Langerhans cell histiocytosis (eosinophilic granuloma) of the skull mimicking nummular headache. Report of two cases.

Cephalalgia 2018 04 10;38(4):794-797. Epub 2017 May 10.

1 Department of Neurology & Neurosurgery, Clinical Hospital of University of Chile, Santiago de Chile, Chile.

Background Nummular headache is a rare, recently described topographic headache defined by the circumscribed coin-shaped area of pain. It is classified as a primary headache. There is debate about whether it is due to a peripheral or central disturbance, and its relationship to migraine. Read More

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April 2018
16 Reads

Genome-wide linkage and sequence analysis challenge CCDC66 as a human retinal dystrophy candidate gene and support a distinct NMNAT1-related fundus phenotype.

Clin Genet 2018 Jan 9;93(1):149-154. Epub 2017 May 9.

Bioscientia, Center for Human Genetics, Ingelheim, Germany.

To uncover the genotype underlying early-onset cone-rod dystrophy and central nummular macular atrophic lesion in 2 siblings from an endogamous Arab family, we performed targeted next-generation sequencing (NGS) of 44 retinal dystrophy genes, whole-exome sequencing (WES) and genome-wide linkage analysis. Targeted NGS and WES in the index patient highlighted 2 homozygous variants, a CCDC66 frameshift deletion and a novel missense NMNAT1 variant, c.500G>A (p. Read More

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January 2018
1 Read

The spectrum of Vogt-Koyanagi-Harada disease in Iran.

Int Ophthalmol 2018 Apr 4;38(2):443-449. Epub 2017 Mar 4.

Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti Medical University, Tehran, Iran.

Purpose: To report the spectrum of Vogt-Koyanagi-Harada (VKH) disease in Persians.

Materials And Methods: This is a retrospective chart review of patients diagnosed with VKH disease at four referral centers in Iran. Patients' demographics, ocular and extraocular manifestations, treatment modalities, complications, and visual outcomes were collected and analyzed. Read More

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April 2018
5 Reads

Clinical and demographic study of microsporidial keratoconjunctivitis in South India: a 3-year study (2013-2015).

Br J Ophthalmol 2017 10 22;101(10):1436-1439. Epub 2017 Feb 22.

Department of Ocular Microbiology, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

Aim: To study the demographic profile, clinical features, treatment outcome and ocular morbidity of smear-positive microsporidial keratoconjunctivitis.

Methods: Retrospective case series of all patients with clinical features of microsporidial keratoconjunctivitis and who were smear positive for the same on Gram stain from January 2013 to December 2015. Demographic data, predisposing factors, microbiological investigations, clinical course and visual outcome were analysed. Read More

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October 2017
5 Reads

Craniosynostosis, delayed closure of the fontanelle, anal, genitourinary, and skin abnormalities (CDAGS syndrome): first report in a Mexican patient and review of the literature.

Int J Dermatol 2017 Apr 19;56(4):435-439. Epub 2017 Feb 19.

Department of Dermatology, Hospital Infantil de México Federico Gómez, México, D.F, Mexico.

Introduction: Craniosynostosis and clavicular hypoplasia, delayed closure of the fontanelle, cranial defects, anal and genitourinary abnormalities, and skin (CDAGS), is an infrequent autosomal recessive entity with only 10 cases reported; no associated gene has been identified so far.

Case Report: The proband is a 2-year-old Mexican female with brachycephaly, cleft palate, anal malformation with rectovestibular fistula, and clinodactyly of the third toe overlapping the second. At 4 months of age, she developed a disseminated dermatosis with erythematous scaly nummular plaques, elevated keratotic sharp borders with thin to broad flaking, hematic crusts, and keratotic surface in others. Read More

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April 2017
12 Reads

The histopathological differentiation between palmar psoriasis and hand eczema: A retrospective review of 96 cases.

J Am Acad Dermatol 2017 Jul 9;77(1):130-135. Epub 2017 Feb 9.

Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.

Background: The histopathologic differences among palmar psoriasis (PP), hand eczema (HE), and hyperkeratotic hand dermatitis (HHD) have been poorly described.

Objectives: We sought to distinguish among PP, HE, and HHD on a histopathologic basis.

Methods: We retrospectively analyzed the histology of hematoxylin-eosin-stained sections obtained from 96 patients diagnosed with PP, HE, or HHD. Read More

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July 2017
11 Reads

Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration.

Clin Ophthalmol 2016 14;10:2497-2503. Epub 2016 Dec 14.

Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences.

Purpose: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument.

Patients And Methods: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Read More

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December 2016
6 Reads

UNILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION.

Authors:
Richard F Spaide

Retin Cases Brief Rep 2018 Fall;12(4):263-265

Vitreous, Retina, Macula Consultants of New York, New York, New York.

Purpose: To report a unilateral case of what is named bilateral diffuse uveal melanocytic proliferation and consider the consequences of this finding.

Methods: The ocular findings were investigated with multimodal imaging to include color fundus photography, fluorescein angiography, autofluorescence imaging, and enhanced depth imaging optical coherence tomography.

Results: A 66-year-old woman had a history of breast cancer 23 years previously that was treated and the patient was free of disease since. Read More

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September 2018
3 Reads

Diagnostic usefulness of dermoscopy in differentiating lichen aureus from nummular eczema.

J Dermatol 2017 May 3;44(5):533-537. Epub 2016 Dec 3.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Lichen aureus (LA) is a variant of pigmented purpuric dermatosis that is characterized clinically by rust macules, papules or plaques, mainly on the legs. In some cases, LA can be difficult to be distinguished from nummular eczema (NE) with the naked eye. Dermoscopy can be applied to skin lesions, revealing additional features that can be highly valuable for correct diagnosis. Read More

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May 2017
9 Reads

Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma.

Dis Markers 2016 16;2016:9602472. Epub 2016 Oct 16.

Dermatology Research Laboratory, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania; Department of Dermatology, Carol Medical Center, 020915 Bucharest, Romania.

Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). While most cases of MF run a mild course over a period of many years, other subtypes of CTCL are very aggressive. Read More

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February 2017
6 Reads

Nummular headache: Clinico-epidemiological features in South Indian population.

J Neurosci Rural Pract 2016 Oct-Dec;7(4):532-536

Department of Neurology, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India.

Context: Nummular headache (NH) is a primary disorder characterized by head pain exclusively felt in a small-rounded area typically 2-6 cm in diameter.

Aims: The aim of this review is to study the clinical and epidemiological features of NH in a patient population of South India and to compare this with that of described in the international literature.

Settings And Design: A prospective, observational study conducted in a tertiary care center. Read More

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October 2016
1 Read

Administration of palmitoylethanolamide in combination with topiramate in the preventive treatment of nummular headache.

Int Med Case Rep J 2016 18;9:193-5. Epub 2016 Jul 18.

Department of Neurosurgery, University of Catanzaro "Magna Graecia", Catanzaro, Italy.

Nummular headache has been recently described as a primary disorder characterized by head pain exclusively felt in a small rounded area typically 2-6 cm in diameter, not attributed to another disorder. Both size and shape of the painful area remain constant since the onset of symptoms. A 57-year-old woman presented with a history of focal episodic pain in a circumscribed area on the right parietal region. Read More

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August 2016
5 Reads

Nummular Headache Associated With Linear Scleroderma.

Headache 2016 Oct 1;56(9):1492-1493. Epub 2016 Aug 1.

Hospital CIMA, Instituto de Medicina y Cirugia Barcelona (IMECBA).

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October 2016
2 Reads

Martinique Crinkled Retinal Pigment Epitheliopathy: Clinical Stages and Pathophysiologic Insights.

Ophthalmology 2016 10 26;123(10):2196-204. Epub 2016 Jul 26.

Institute for Neurosciences of Montpellier U1051, University of Montpellier - University Hospital, Genetics of Sensory Diseases, Montpellier, France. Electronic address:

Purpose: To reappraise the autosomal dominant Martinique crinkled retinal pigment epitheliopathy (MCRPE) in light of the knowledge of its associated mutated gene mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3), an actor in the p38 mitogen-activated protein kinase pathway.

Design: Clinical and molecular study.

Participants: A total of 45 patients from 3 generations belonging to a family originating from Martinique with an autosomal dominant MCRPE were examined. Read More

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October 2016
15 Reads

[Keratitis - Infectious or Autoimmune?].

Authors:
E M Messmer

Klin Monbl Augenheilkd 2016 Jul 28;233(7):808-12. Epub 2016 Jul 28.

Augenklinik, Klinikum der Universität München.

Histopathological evaluation of ocular tissues is important in differentiating between infectious and autoimmune disease. Inflammation, necrosis and keratolysis are common to most forms of keratitis. Histopathology can be of great help in identifying the causative organism, establishing a final diagnosis and/or managing the patient with herpes simplex virus keratitis, mycotic keratitis, acanthamoeba keratitis or microsporidia keratoconjunctivitis. Read More

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Dermatophytosis in donkeys (Equus asinus) due to Microsporum racemosum, an unusual geophilic agent.

Med Mycol Case Rep 2016 Jun 21;12:8-10. Epub 2016 Jun 21.

Dipartimento di Scienze Veterinarie, Università di Pisa, Viale delle Piagge, 2, I 56124 Pisa, Italy.

Reports about ringworm in donkeys are scanty and refer to zoonotic agents such as Trichophyton mentagrophytes and Trichophyton verrucosum. Seventeen Asino Amiatina donkeys semi-extensively farmed in paddocks showed alopecic nummular, scaling areas mainly on head and neck. Microsporum racemosum cultivated from the lesions was identified by morphology and PCR. Read More

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June 2016
1 Read

[Nummular dermatitis: report of two cases in children].

Arch Argent Pediatr 2016 Aug 1;114(4):e241-4. Epub 2016 Aug 1.

Centro de Salud "Severo Ochoa", Gijón, Asturias, España.

Nummular eczema or dermatitis is an uncommon paediatric pathology. It is presented as red-purplish small papules and vesicles that join to form exudative circular patches and then to eczematous or lichenified patches with discoid shape. The lesions appear predominantly on the extensor surface of extremities, although they can appear in trunk, hands or feet. Read More

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August 2016
8 Reads

Acute Hemorrhagic Edema of Infancy: Still a Challenge for the Pediatrician.

Pediatr Emerg Care 2018 Feb;34(2):e28-e29

We report a case of acute hemorrhagic edema of infancy (AHEI) occurred in an 11-month-old male infant after upper respiratory tract infection. The onset was dramatic with petechiae, ecchymosis, and annular, nummular, or targetoid purpuric plaques on the extremities, face, and ears. Acute hemorrhagic edema of infancy is a benign form of leukocytoclastic vasculitis that typically affects children between 4 and 24 months of age. Read More

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February 2018
3 Reads
0.920 Impact Factor

Herpes Simplex Virus-2 Esophagitis in a Young Immunocompetent Adult.

Case Rep Gastrointest Med 2016 19;2016:7603484. Epub 2016 Apr 19.

Department of Medicine, Bridgeport Hospital-Yale New Haven Health, Bridgeport, CT 06610, USA; Department of Gastroenterology, Bridgeport Hospital-Yale New Haven Health, Bridgeport, CT 06610, USA.

Herpes simplex esophagitis (HSE) is commonly identified in immunosuppressed patients. It is rare among immunocompetent patients and almost all of the reported cases are due to HSV-1 infection. HSV-2 esophagitis is extremely rare. Read More

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May 2016
2 Reads

Importance of Skin Changes in the Differential Diagnosis of Congenital Muscular Dystrophies.

Biomed Res Int 2016 31;2016:3128735. Epub 2016 Mar 31.

University Hospital of Cologne, Institute of Human Genetics, 50931 Cologne, Germany; University Hospital of Cologne, Department of Pediatrics, 50931 Cologne, Germany; Center for Molecular Medicine, 50931 Cologne, Germany.

Megaconial congenital muscular dystrophy (OMIM 602541) is characterized with early-onset hypotonia, muscle wasting, proximal weakness, cardiomyopathy, mildly elevated serum creatine kinase (CK) levels, and mild-to-moderate intellectual disability. We report two siblings in a consanguineous family admitted for psychomotor delay. Physical examination revealed proximal muscle weakness, contractures in the knee of elder sibling, diffuse mild generalized muscle atrophy, and dry skin with ichthyosis together with multiple nummular eczema in both siblings. Read More

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January 2017
6 Reads

Phenotypic features of CRB1-associated early-onset severe retinal dystrophy and the different molecular approaches to identifying the disease-causing variants.

Graefes Arch Clin Exp Ophthalmol 2016 Sep 25;254(9):1833-9. Epub 2016 Apr 25.

Department of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.

Purpose: The aim of this study was to determine the molecular genetic basis of an early-onset severe retinal dystrophy in three unrelated consecutive patients of Czech origin and to describe their ocular phenotype.

Methods: DNA samples from two probands were analyzed using a genotyping microarray (Asper) followed by either target analysis of 43 genes implicated in retinal disorders by next generation sequencing or whole-exome sequencing, respectively. The third proband underwent conventional Sanger sequencing of CRB1 based on her ocular findings. Read More

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September 2016
16 Reads

A recurrent headache circumscribed in a coronal line-shaped area around the head: a coronal linear headache.

Springerplus 2016 10;5:315. Epub 2016 Mar 10.

Department of Neurology, Epilepsy and Headache Group, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, 230022 China ; Department of Neurology, The Second Division Korla Hospital of Xinjiang Production and Construction Corps, Jiaotong Road, Korla, 841000 Xinjiang China.

Background: Linear headache (LH) has recently been described as a paroxysmal or continuous head pain restricted in a linear trajectory of 5-10 mm in width, linking one endpoint in occipital or occipitocervical region with another endpoint in ipsilateral nasion or forehead region. The sagittal line-shaped pain area of LH is close and parallel to a sagittal venous sinus, the superior sagittal sinus (SSS). For some patients, the LH had some features resembling the pattern of migraine without aura. Read More

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April 2016
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Linear headache: clinical characteristics of eight new cases.

Springerplus 2016 18;5:347. Epub 2016 Mar 18.

Department of Neurology, Epilepsy and Headache Group, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, 230022 China.

Background: Linear headache (LH) has recently been described as a paroxysmal or continuous fixed head pain restricted in a linear trajectory of 5-10 mm in width, linking one endpoint in occipital or occipitocervical region with another endpoint in ipsilateral nasion or forehead region. For some patients, this headache had some features resembling migraine without aura.

Methods: We made a prospective search of patients presenting with a clinical picture comprised under the heading of LH and we have accessed eight new cases. Read More

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April 2016
11 Reads

Leprosy in the Bible.

Clin Dermatol 2016 Jan-Feb;34(1):3-7. Epub 2015 Nov 17.

Domestic and Specialized Medicine Centre "Dilmed", ul. Bohaterów Monte Cassino 3, 40-231 Katowice, Poland. Electronic address:

For many years, the biblical term tzaraat has referred to leprosy. In fact, the disease or diseases described under this name have no relationship to leprosy, as it was known in the Middle Ages or today; moreover, the term referred not only to skin disease, but also to the state of the ritual impurity and punishment for the sins. Although the real nature of tzaraat remains unknown, the differential diagnosis might include the following: Psoriasis, seborrheic dermatitis, favus, dermatophyte infections, nummular dermatitis, atopic dermatitis, pityriasis rosea, crusted scabies, syphilis, impetigo, sycosis barbae, alopecia areata, furuncles, scabies, neurodermatitis, scarlet fever, lupus erythematosus, lichen sclerosus et atrophicus, folliculitis decalvans, morphea, sarcoidosis, and lichen planopilaris. Read More

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October 2016
12 Reads

Nummular Eczema of Breast: A Potential Dermatologic Complication after Mastectomy and Subsequent Breast Reconstruction.

Plast Surg Int 2015 24;2015:209458. Epub 2015 Aug 24.

Tokyo Breast Surgery Clinic, Japan.

Purposes. The present paper reports clinical cases where nummular eczema developed during the course of breast reconstruction by means of implantation and evaluates the occurrence patterns and ratios of this complication. Methods. Read More

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September 2015
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Pitfalls in Diagnosing Neuraminidase Deficiency: Psychosomatics and Normal Sialic Acid Excretion.

JIMD Rep 2016 5;25:9-13. Epub 2015 Jul 5.

Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.

Neuraminidase deficiency (mucolipidosis I, sialidosis types I and II, cherry-red spot myoclonus syndrome) is a lysosomal storage disorder with an expanding clinical phenotype. Here, we report the striking diagnostic history of late-onset neuraminidase deficiency in two sisters, currently aged 14 (patient 1) and 15 (patient 2).Patient 1 was referred for evaluation of her vision after a traffic accident. Read More

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July 2015
2 Reads

Paraproteinemic Keratopathy: The Expanding Diversity of Clinical and Pathologic Manifestations.

Ophthalmology 2015 Sep 26;122(9):1748-56. Epub 2015 Jun 26.

Department of Ophthalmology, North Shore-Long Island Jewish Health System, Manhasset, New York.

Purpose: To describe 7 patients with paraproteinemic keratopathy and to highlight the clinical and pathologic diversity of this rare entity and the importance of timely, systemic evaluation.

Design: Retrospective, multicenter collaborative case series.

Participants: Seven patients with paraproteinemic keratopathy. Read More

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September 2015
2 Reads