4,512 results match your criteria Nuclear medicine and biology[Journal]


Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction.

Nucl Med Biol 2019 Jan 17. Epub 2019 Jan 17.

Department of Medical Imaging, University of Arizona, Tucson, AZ, United States of America. Electronic address:

Introduction: The objective of this study was to investigate the cardioprotective effects of a dodecafluoropentane (DDFP)-based perfluorocarbon emulsion (DDFPe) as an artificial carrier for oxygen delivery to ischemic myocardium, using Tc-duramycin SPECT imaging.

Methods: Rat hearts with Ischemia-reperfusion (I/R) was prepared by coronary ligation for 45-min followed by reperfusion. The feasibility of Tc-duramycin in detecting myocardial I/R injury and its kinetic profile were first verified in the ischemic hearts with 2-h reperfusion (n = 6). Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2019.01.004DOI Listing
January 2019

Synthesis and evaluation of Tc-analogues of [I]mIBG prepared via [Tc][Tc(CO)(HO)] synthon for targeting norepinephrine transporter.

Nucl Med Biol 2019 Jan 18. Epub 2019 Jan 18.

Homi Bhabha National Institute (HBNI), Anushaktinagar, Mumbai 400094, India; Radiopharmaceutical Division, Bhabha Atomic Research Centre (BARC), Trombay, Mumbai 400085, India.

Introduction: meta-[I]Iodobenzylguanidine (mIBG) is a clinical agent used for imaging neuroendocrine tumors, where uptake in tumor is via active transport mechanism through norepinephrine transporters (NET). Our group in past have evaluated a Tc-analogue of the above tracer, based on Tc-4 + 1 labeling approach, which exhibited significant affinity for NET but suffered from reduced specific uptake in comparison to reference standard no-carrier-added (n.c. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2019.01.001DOI Listing
January 2019

Facile radiochemical separation of clinical-grade Y from Sr by selective precipitation for targeted radionuclide therapy.

Nucl Med Biol 2019 Jan 19. Epub 2019 Jan 19.

Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400 094, India.

Introduction: The widespread clinical utilization of Y for preparation of target specific radiopharmaceuticals demands development of a facile, efficient and cost-effective method for radiochemical separation of Y from Sr viaSr/Y generator. In this article, we describe an efficient and facile method for radiochemical separation of Y from Sr for preparation of radiopharmaceuticals by exploiting the large difference in the solubility product constants (K) of Y(OH) and Sr(OH).

Methods: A two-step radiochemical separation procedure based on selective precipitation of Y under alkaline conditions from Sr/Y equilibrium mixture was developed. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2019.01.002DOI Listing
January 2019

Prostate cancer and inflammation: A new molecular imaging challenge in the era of personalized medicine.

Nucl Med Biol 2019 Jan 19. Epub 2019 Jan 19.

Department of Experimental Medicine and Surgery, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.

The relationship between cancer and inflammation is one of the most important fields for both clinical and translational research. Despite numerous studies reported interesting and solid data about the prognostic value of the presence of inflammatory infiltrate in cancers, the biological role of inflammation in prostate cancer development is not yet fully clarified. The characterization of molecular pathways that connect altered inflammatory response and prostate cancer progression can provide the scientific rationale for the identification of new prognostic and predictive biomarkers. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2019.01.003DOI Listing
January 2019

Validation of hepatobiliary transport PET imaging in liver function assessment: Evaluation of 3β-[F]FCA in mouse models of liver disease.

Nucl Med Biol 2018 Dec 8. Epub 2018 Dec 8.

Faculty of Pharmaceutical Sciences, Laboratory of Radiopharmacy, Ghent University, Ghent, Belgium.

Recently, our research group reported on the development of 3β-[F]Fluorocholic acid (3β-[F]FCA), a F labeled bile acid to detect drug interference with the bile acid transporters (drug-induced cholestasis). It was hypothesized that 3β-[F]FCA could also be used as a non-invasive tool to monitor (regional) liver function in vivo in different liver diseases through altered expression of bile acid transporters.

Methods: Hepatobiliary transport of 3β-[F]FCA was evaluated in four murine liver disease models. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.12.001DOI Listing
December 2018

Development of [F]FAMTO: A novel fluorine-18 labelled positron emission tomography (PET) radiotracer for imaging CYP11B1 and CYP11B2 enzymes in adrenal glands.

Nucl Med Biol 2018 Nov 9. Epub 2018 Nov 9.

School of Imaging Sciences & Biomedical Engineering, 4th floor Lambeth Wing, St Thomas' Hospital, King's College London, London SE1 7EH, United Kingdom. Electronic address:

Introduction: Primary aldosteronism accounts for 6-15% of hypertension cases, the single biggest contributor to global morbidity and mortality. Whilst ~50% of these patients have unilateral aldosterone-producing adenomas, only a minority of these have curative surgery as the current diagnosis of unilateral disease is poor. Carbon-11 radiolabelled metomidate ([C]MTO) is a positron emission tomography (PET) radiotracer able to selectively identify CYP11B1/2 expressing adrenocortical lesions of the adrenal gland. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.11.002DOI Listing
November 2018

Ga-labelled NOTA-RGD-GE11 peptide for dual integrin and EGFR-targeted tumour imaging.

Nucl Med Biol 2018 Nov 28. Epub 2018 Nov 28.

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan City, Taiwan, ROC. Electronic address:

Introduction: Multiple peptide receptors are co-expressed in many types of cancers. Arg-Gly-Asp (RGD) and GE11 peptides specifically target integrin αβ and EGFR, respectively. Recently, we designed and synthesized a heterodimer peptide NOTA-c(RGDyK)-GE11 (NOTA-RGD-GE11). Read More

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November 2018
2 Reads

In vivo imaging characterization and anticancer efficacy of a novel HER2 affibody and pemetrexed conjugate in lung cancer model.

Nucl Med Biol 2018 Nov 28. Epub 2018 Nov 28.

Department of Nuclear Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

Introduction: In this study, a new agent consisting of HER2-specific affibody Z and chemotherapy drug pemetrexed was synthesized to develop a new targeted drug. Its biological characteristics and anticancer efficacy were assessed in cells level and xenografts models by radiolabeling with technetium-99m.

Methods: After the Z-pemetrexed conjugate was synthesized, radiolabeling of the conjugate was performed using its C-terminal 4 amino acids (Gly-Gly-Gly-Cys) as the chelating moiety. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.11.004DOI Listing
November 2018
3 Reads

Synthesis, characterization and biological studies of rhenium, technetium-99m and rhenium-188 pentapeptides.

Nucl Med Biol 2018 Nov 12. Epub 2018 Nov 12.

Department of Chemistry, Hunter College of the City University of New York, New York, NY, USA; Department of Chemistry, Graduate Center of the City University of New York, New York, NY, USA.

A pentapeptide macrocyclic ligand, KYCAR (lysyl-tyrosyl-cystyl-alanyl-arginine), has been designed as a potential chelating ligand for SPECT imaging and therapeutic in vivo agents. This study shows the synthesis and characterization of KYCAR complexes containing nonradioactive rhenium, Tc, or Re. The metal complexes were also biologically evaluated to determine in vivo distribution in healthy mice. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.11.001DOI Listing
November 2018
2 Reads

Tumor uptake and tumor/blood ratios for [Zr]Zr-DFO-trastuzumab-DM1 on microPET/CT images in NOD/SCID mice with human breast cancer xenografts are directly correlated with HER2 expression and response to trastuzumab-DM1.

Nucl Med Biol 2018 12 16;67:43-51. Epub 2018 Oct 16.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; Toronto General Research Institute and Joint Department of Medical Imaging, University Health Network, Toronto, ON, Canada. Electronic address:

Introduction: Our objective was to determine correlations between the tumor uptake and T/B ratios for Zr-labeled T-DM1 (Zr-DFO-T-DM1) in mice with human BC xenografts by microPET/CT and biodistribution studies with HER2 expression and response to treatment with trastuzumab-DM1 (T-DM1).

Methods: The tumor and normal tissue uptake and T/B ratios for Zr-DFO-T-DM1 (10 μg; 7.0 MBq) incorporated into a therapeutic dose (60 μg) were determined by microPET/CT and biodistribution studies at 96 h p. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09698051183025
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http://dx.doi.org/10.1016/j.nucmedbio.2018.10.002DOI Listing
December 2018
17 Reads

Al[F]F-complexation of DFH17, a NOTA-conjugated adrenomedullin analog, for PET imaging of pulmonary circulation.

Nucl Med Biol 2018 12 16;67:36-42. Epub 2018 Oct 16.

University of Montreal Hospital Research Centre, 900 rue Saint-Denis, Montréal, Québec H2X 3H8, Canada; Department of Biomedical Engineering, Faculty of Medicine, Université de Montréal, Pavillon Paul-G. Desmarais, 2960 chemin de la Tour, Montréal, Québec H3T 1J4, Canada; Department of Radiology, Radio-oncology and Nuclear Medicine, Université de Montréal, Pavillon Roger-Gaudry, 2900 Boulevard Edouard Montpetit, Montréal, Québec H3T 1J4, Canada. Electronic address:

Introduction: Adrenomedullin receptors are highly expressed in human alveolar capillaries and provide a molecular target for imaging the integrity of pulmonary microcirculation. In this work, we aimed to develop a NOTA-derivatized adrenomedullin analog (DFH17), radiolabeled with [F]AlF, for PET imaging of pulmonary microcirculation.

Methods: Highly concentrated [F](AlF) (15 μL) was produced from purified fluorine-18 in NaCl 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09698051183026
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December 2018
6 Reads

Efficient cartridge purification for producing high molar activity [F]fluoro-glycoconjugates via oxime formation.

Nucl Med Biol 2018 12 15;67:27-35. Epub 2018 Oct 15.

Department of Chemistry - Radiochemistry, University of Helsinki, Helsinki, Finland. Electronic address:

Introduction: F-fluoroglycosylation via oxime formation is a chemoselective and mild radiolabeling method for sensitive molecules. Glycosylation can also improve the bioavailability, in vivo kinetics, and stability of the compound in blood, as well as accelerate clearance of biomolecules. A typical synthesis procedure for F-fluoroglycosylation with [F]FDG (2-deoxy-2-[F]fluoro-d-glucose) and [F]FDR (5-deoxy-5-[F]fluoro-d-ribose) involves two HPLC (high performance liquid chromatography) purifications: one after F-fluorination of the carbohydrate to remove its labeling precursor, and a second one after the oxime formation step to remove the aminooxy precursor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09698051183020
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http://dx.doi.org/10.1016/j.nucmedbio.2018.10.001DOI Listing
December 2018
3 Reads

Molar activity - The keystone in C-radiochemistry: An explorative study using the gas phase method.

Nucl Med Biol 2018 12 12;67:21-26. Epub 2018 Oct 12.

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria; CBmed GmbH - Center for Biomarker Research in Medicine, Graz, Austria.

Introduction: Radiochemists/radiopharmacists, involved in the preparation of radiopharmaceuticals are regularly confronted with the requirement of continuous high quality productions in their day-to-day business. One of these requirements is high specific or molar activity of the radiotracer in order to avoid e.g. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09698051183022
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http://dx.doi.org/10.1016/j.nucmedbio.2018.09.003DOI Listing
December 2018
1 Read

Unexpected decrease in in vivo binding of [H]QNB in the mouse cerebral cortex in the developing brain - A comparison with [C]NMPB.

Nucl Med Biol 2018 12 16;67:15-20. Epub 2018 Oct 16.

Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan. Electronic address:

Introduction: Significant discrepancies between in vitro and in vivo binding of the muscarinic receptor ligand - H-labeled Quinuclidinyl Benzilate (QNB) - have been well documented. Discernable in vivo cerebellar [H]QNB binding has been observed in mouse brain, despite the maximum number of binding sites (B) being low. In order to understand this unique in vivo binding phenomenon, the binding of two muscarinic receptor ligands - [H]QNB and N-[C]methylpiperidyl Benzilate ([C]NMPB) - were compared in vivo and in vitro in 3- and 8-week-old mice. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.10.004DOI Listing
December 2018
1 Read

Automated radiosynthesis of 5-[C]l-glutamine, an important tracer for glutamine utilization.

Nucl Med Biol 2018 12 15;67:10-14. Epub 2018 Oct 15.

Vanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University Institute for Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Chemistry, Vanderbilt University, Nashville, TN, USA. Electronic address:

Introduction: The natural amino acid l-Glutamine (Gln) is essential for both cell growth and proliferation. In addition to glucose, cancer cells utilize Gln as a carbon source for ATP production, biosynthesis, and as a defense against reactive oxygen species. The utilization of [C]Gln has been previously reported as a biomarker for tissues with an elevated demand for Gln, however, the previous reports for the preparation of [C]Gln were found to be lacking several crucial aspects necessary for transition to human production. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09698051183023
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http://dx.doi.org/10.1016/j.nucmedbio.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298813PMC
December 2018
17 Reads

[F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease.

Nucl Med Biol 2018 12 26;67:1-9. Epub 2018 Sep 26.

PET Preclinical Imaging Laboratory, Turku PET Centre, University of Turku, Finland; MediCity Research Laboratory, University of Turku, Finland.

Introduction: Neuroinflammation is associated with several neurological disorders, including Alzheimer's disease (AD). The translocator protein 18 kDa (TSPO), due to its overexpression during microglial activation and relatively low levels in the brain under normal neurophysiological conditions, is commonly used as an in vivo biomarker for neuroinflammation. Reported here is the preclinical evaluation of [F]F-DPA, a promising new TSPO-specific radioligand, as a tool for the detection of activated microglia at different ages in the APP/PS1-21 mouse model of AD and a blocking study to determine the specificity of the tracer. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.09.001DOI Listing
December 2018
11 Reads

Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs.

Nucl Med Biol 2018 11 24;66:49-57. Epub 2018 Aug 24.

Div. of Radiology and Nuclear Medicine, Oslo University Hospital, PO box 4950, Nydalen, N-0424 Oslo, Norway; Faculty of Medicine, University of Oslo, PO Box1078, Blindern, N-0316 Oslo, Norway.

Introduction: Inflammation associated with microglial activation may be an early prognostic indicator of perinatal hypoxic ischemic injury, where translocator protein (TSPO) is a known inflammatory biomarker. This piglet study used dynamic TSPO-PET with [F]GE180 to evaluate if microglial activation after global perinatal hypoxic injury could be detected.

Methods: New born anesthetized pigs (n = 14) underwent hypoxia with fraction of inspired oxygen (FiO)0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09698051183002
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http://dx.doi.org/10.1016/j.nucmedbio.2018.08.004DOI Listing
November 2018
3 Reads

Synthesis and evaluation of an N-[F]fluorodeoxyglycosyl amino acid for PET imaging of tumor metabolism.

Nucl Med Biol 2018 11 16;66:40-48. Epub 2018 Aug 16.

Shanxi Medical University, Taiyuan, People's Republic of China. Electronic address:

Introduction: The limitations of [F]fluorodeoxyglucose ([F]FDG), including producing false-positive or -negative results, low image contrast in brain tumor diagnosis and poor differentiation of tumor and inflammatory, necessitate the development of new radiopharmaceuticals. In the present study, a novel [F]fluoroglycoconjugate tracer, [F]FDGly-NH-Phe, for tumor metabolism imaging was prepared and evaluated.

Methods: [F]FDGly-NH-Phe was prepared by condensing [F]FDG with L-4-aminophenylalanine in an acidic condition, and purified with semi-preparative-high performance liquid chromatography (HPLC). Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.08.002DOI Listing
November 2018

Issues in preclinical radiopharmaceutical research: Significance, relevance and reproducibility.

Nucl Med Biol 2018 12 3;67:52-55. Epub 2018 Sep 3.

Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48105, United States of America.

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http://dx.doi.org/10.1016/j.nucmedbio.2018.07.002DOI Listing
December 2018
1 Read
2.412 Impact Factor

Assessing the feasibility of intranasal radiotracer administration for in brain PET imaging.

Nucl Med Biol 2018 11 30;66:32-39. Epub 2018 Aug 30.

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London SE 5 8AF, United Kingdom.

Introduction: The development of clinically useful tracers for PET imaging is enormously challenging and expensive. The intranasal (IN) route of administration is purported to be a viable route for delivering drugs to the brain but has, as yet, not been investigated for the delivery of PET tracers. If the intranasal (IN) pathway presents a viable option, it extends the PET imaging field by increasing the number of tracers available for human use. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288068PMC
November 2018

Preliminary evaluation of a novel F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer.

Nucl Med Biol 2018 11 24;66:26-31. Epub 2018 Aug 24.

Department of Chemistry, University of Illinois at Urbana-Champaign, IL 61801, United States of America.

Introduction: Poly (ADP-ribose) polymerase-1 (PARP-1) plays many roles in prostate cancer (PC), such as mediating DNA damage repair, transcriptional regulation and nuclear hormone receptor signaling. Because of this, PARP-1 has been targeted for therapy in PC, and non-invasive imaging of PARP-1 could help predict which patients are likely to respond to such therapy. Several PARP-1 positron emission tomography (PET) imaging agents have been developed and show promise for imaging PARP-1 expression in breast, brain, and lung cancer in small animals, but not as yet in prostate cancer. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252111PMC
November 2018
8 Reads
2.412 Impact Factor

[Tc]Tc-duramycin, a potential molecular probe for early prediction of tumor response after chemotherapy.

Nucl Med Biol 2018 11 9;66:18-25. Epub 2018 Aug 9.

Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Center for Biomedical Imaging, Fudan University, Shanghai 200032, China; Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai 200032, China; Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Objective: Apoptosis plays a crucial role in many biological processes, especially in cancer. However, real-time monitoring of apoptosis is challenging. [Tc]duramycin can selectively target an apoptosis biomarker: phosphatidylethanolamine (PE), which is normally located on the intracellular cell-membrane surface but redistributes onto the outer cell-membrane upon apoptosis. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.07.003DOI Listing
November 2018
2 Reads

Effects of adding an albumin binder chain on [Lu]Lu-DOTATATE.

Nucl Med Biol 2018 11 9;66:10-17. Epub 2018 Aug 9.

Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada; Department of Radiology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada. Electronic address:

Introduction: [Lu]Lu-DOTATATE peptide receptor radionuclide therapy is used for treatment of neuroendocrine tumours. We investigated whether prolonging blood residence time of [Lu]Lu-DOTATATE with albumin binders could increase tumour accumulation and tumour-to-kidney ratios for improved therapeutic efficacy.

Methods: DOTATATE and its derivatives with an albumin-binder motif (GluAB-DOTATATE and AspAB-DOTATATE) were prepared by solid-phase peptide synthesis. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.08.001DOI Listing
November 2018
1 Read

Fluorine-18 labeled diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain.

Nucl Med Biol 2018 11 4;66:1-9. Epub 2018 Jul 4.

Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Objectives: Serotonin transporters (SERT) play an important role in controlling serotonin concentration in the synaptic cleft and in managing postsynaptic signal transduction. Inhibitors of SERT binding are well known as selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, sertraline, paroxetine, and escitalopram, that are commonly prescribed antidepressants. Positron emission tomography (PET) and single photon emission tomography (SPECT) imaging agents targeting SERT may be useful for studying its function and providing a tool for monitoring drug treatment. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.06.008DOI Listing
November 2018
16 Reads

Improving metabolic stability of fluorine-18 labeled verapamil analogs.

Nucl Med Biol 2018 Sep - Oct;64-65:47-56. Epub 2018 Jul 5.

Department of Radiology & Nuclear Medicine, VU University Medical Center Amsterdam, the Netherlands.

Introduction: Fluorine-18 labeled positron emission tomography (PET) tracers were developed to obtain more insight into the function of P-glycoprotein (P-gp) in relation to various conditions. They allow research in facilities without a cyclotron as they can be transported with a half-life of 110 min. As the metabolic stability of previously reported tracers [F]1 and [F]2 was poor, the purpose of this study was to improve this stability using deuterium substitution, creating verapamil analogs [F]1-d, [F]2-d, [F]3-d and [F]3-d. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.06.009DOI Listing
February 2019
16 Reads

Predicting response to sepantronium bromide (YM155), a survivin suppressant, by PET imaging with [C]YM155.

Nucl Med Biol 2018 Sep - Oct;64-65:41-46. Epub 2018 Jun 27.

Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Japan. Electronic address:

Introduction: Sepantronium bromide (YM155) is a survivin suppressant that induces apoptosis in tumor cells. Although YM155 induces tumor regression in various tumor types in vivo, phase I and II studies demonstrated responding and non-responding patient populations. We investigated C-labeled YM155 ([C]YM155) used as a positron emission tomography (PET) tracer to assess whether tumor uptake of [C]YM155 correlated with its anti-tumor effect, thereby allowing identification of patients who would respond to YM155 treatment. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.06.005DOI Listing
February 2019
1 Read

Preclinical study of an F-labeled glutamine derivative for cancer imaging.

Nucl Med Biol 2018 Sep - Oct;64-65:34-40. Epub 2018 Jul 6.

Peking University-Tsinghua University Center for Life Sciences, Beijing 100871, China; Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. Electronic address:

Introduction: The emerging evidence that demonstrated the extra-demand of glutamine for cancer surviving strongly called for the development of PET tracer for imaging glutamine uptake in cancer. In this work, [F]Gln-BF as a natural glutamine derivative was synthesized to explore its potential application of imaging glutamine uptake for cancer diagnosis.

Methods: [F]Gln-BF was prepared by deprotection of purified precursor trityl-Gln-BF (amide bond protected with triphenylmethyl group) using TFA and radiolabeled using F-F isotope exchange protocol. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.06.007DOI Listing
February 2019
32 Reads

Influence of transport line material on the molar activity of cyclotron produced [F]fluoride.

Nucl Med Biol 2018 Sep - Oct;64-65:8-15. Epub 2018 Jun 30.

Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland; Department of Chemistry, University of Turku, Turku, Finland. Electronic address:

Introduction: Production of fluorine-18-labeled radiopharmaceuticals is always associated with the varying levels of the same compound containing stable fluorine-19. In practice, this affects the molar activity (A), defined as amount of radioactivity divided by the molar quantity (Bq/mol). We have focused on studying how the material of the transport tubing connecting the cyclotron target chamber to the synthesis device affects the concentration of fluoride in the water arriving to the reaction vessel and subsequently the A of the fluorine-18 labeled radiopharmaceuticals produced. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.06.004DOI Listing
February 2019

One-pot enzymatic synthesis of l-[3-C]lactate for pharmacokinetic analysis of lactate metabolism in rat brain.

Nucl Med Biol 2018 Sep - Oct;64-65:28-33. Epub 2018 Jul 7.

Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.

Introduction: Lactate could serve as an energy source and signaling molecule in the brain, although there is insufficient in vivo evidence to support this possibility. Here we aimed to use a one-pot enzymatic synthetic procedure to synthesize l-[3-C]lactate that can be used to evaluate chemical forms in the blood after intravenous administration, and as a probe for pharmacokinetic analysis of lactate metabolism in in vivo positron emission tomography (PET) scans with normal and fasted rats.

Methods: Racemic [3-C]alanine obtained from C-methylation of a precursor and deprotection was reacted with an enzyme mixture consisting of alanine racemase, d-amino acid oxidase, catalase, and lactate dehydrogenase to yield l-[3-C]lactate via [3-C]pyruvate. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.07.001DOI Listing
February 2019
3 Reads

Establishment of a method for in-vivo SPECT/CT imaging analysis of In-labeled exendin-4 pancreatic uptake in mice without the need for nephrectomy or a secondary probe.

Nucl Med Biol 2018 Sep - Oct;64-65:22-27. Epub 2018 Jun 8.

Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:

Introduction: Radiolabeled exendin derivatives have been developed to visualize and quantify pancreatic beta cells. However, there are currently no established methods for analyzing in-vivo SPECT/CT images to quantify probe accumulation in the pancreas in rodent models. In this study, we aimed to establish an analytical method for murine in-vivo SPECT/CT imaging. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.06.002DOI Listing
February 2019
1 Read

Semi-automated system for concentrating Ga-eluate to obtain high molar and volume concentration of Ga-Radiopharmaca for preclinical applications.

Nucl Med Biol 2018 Sep - Oct;64-65:16-21. Epub 2018 Jun 27.

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.

Introduction: Ga-radiopharmaceuticals are common in the field of Nuclear Medicine to visualize receptor-mediated processes. In contrast to straightforward labeling procedures for clinical applications, preclinical in vitro and in vivo applications are hampered for reasons like e.g. Read More

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February 2019
22 Reads

Evaluation of a chloride-based Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin.

Nucl Med Biol 2018 Sep - Oct;64-65:1-7. Epub 2018 Jun 18.

Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave., Madison, WI 53705, USA. Electronic address:

Introduction: The remarkable stability of the Zr-DOTA complex has been shown in recent literature. The formation of this complex appears to require Zr-chloride as the complexation precursor rather than the more conventional Zr-oxalate. In this work we present a method for the direct isolation of Zr-chloride from irradiated Y foils. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153039PMC
February 2019
5 Reads

Matched-pair, Y/Y-labeled, bivalent RGD/bombesin antagonist, [RGD-Glu-[DO3A]-6-Ahx-RM2], as a potential theranostic agent for prostate cancer.

Nucl Med Biol 2018 Jul - Aug;62-63:71-77. Epub 2018 Jun 8.

Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, 65201, United States; Department of Radiology, University of Missouri School of Medicine, Columbia, MO 65211, United States; University of Missouri Research Reactor Center, University of Missouri, Columbia, MO 65211, United States. Electronic address:

Introduction: In this study, we describe development of a true matched-pair theranostic agent that is able to target the αβ integrin and the gastrin releasing peptide receptor (GRPR). We herein describe methods to metallate and characterize the new conjugate and to validate its biological efficacy by in vitro and in vivo methods.

Methods: We have previously described the development of [RGD-Glu-6Ahx-RM2] (where RGD: Arg-Gly-Asp; Glu: glutamic acid; 6-Ahx: 6-amino hexanoic acid; RM2: (D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2)) that has been conjugated to a DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) bifunctional chelating agent (BFCA) to afford [RGD-Glu-[DO3A]-6-Ahx-RM2] peptide. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072280PMC
February 2019
7 Reads
2.412 Impact Factor

One-pot synthesis and biodistribution of fluorine-18 labeled serum albumin for vascular imaging.

Nucl Med Biol 2018 Jul - Aug;62-63:63-70. Epub 2018 May 30.

Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Introduction: Equilibrium single-photon radionuclide imaging methods for assessing cardiac function and the integrity of the vascular system have long been in use for both clinical and research purposes. However, positron-emitting blood pool agents that could provide PET equivalents to these (and other) clinical procedures have not yet been adopted despite technical imaging advantages offered by PET. Our goal was to develop a PET blood pool tracer that not only meets necessary in vivo biological requirements but can be produced with an uncomplicated and rapid synthesis method which would facilitate clinical translation. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139435PMC
February 2019
3 Reads

Tc labeled (LPR): A novel retro-inverso peptide for VEGF receptor-1 targeted tumor imaging.

Nucl Med Biol 2018 Jul - Aug;62-63:54-62. Epub 2018 May 31.

Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Introduction: The aim of this study was to evaluate the ability of (LPR), a novel retro-inverso peptidomimetic derivative for imaging colon cancer.

Methods: Two different (LPR) analogs were designed and compared based on conjugation of HYNIC at peptide's C or N terminal and then labeled with technetium-99m using tricine/EDDA as an exchange coligands. The radiolabeled conjugates were assessed for in vitro stability in saline and serum. Read More

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February 2019
2 Reads

Gallium-68 labeled Ubiquicidin derived octapeptide as a potential infection imaging agent.

Nucl Med Biol 2018 Jul - Aug;62-63:47-53. Epub 2018 May 4.

Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC), Mumbai 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India.

Introduction: Gallium-68 based infection imaging agents are in demand to detect infection foci with high spatial resolution and sensitivity. In this study, Ubiquicidin derived octapeptide, UBI (31-38) conjugated with macrocyclic chelator NOTA was radiolabeled with Ga to develop infection imaging agent.

Methods: Circular dichroism (CD) spectroscopy was performed to study conformational changes in UBI (31-38) and its NOTA conjugate in a "membrane like environment". Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.04.003DOI Listing
February 2019
26 Reads
2.412 Impact Factor

What about αβ integrins in molecular imaging in oncology?

Nucl Med Biol 2018 Jul - Aug;62-63:31-46. Epub 2018 May 4.

Université de Bordeaux, CNRS, INCIA, UMR 5287, Bordeaux, France.

Non-invasive investigation of integrin expression is an interesting approach in nuclear medicine department. Indeed, integrins are overexpressed in a wide array of diseases, including tumor neoangiogenesis, cardiovascular pathologies, immune dysfunction, etc. Different targets have been identified in order to be detected and quantified for angiogenesis and vascular remodeling, among them VEGF, matrix metalloproteases, and integrins (αβ, but also αß and αβ). Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.04.006DOI Listing
February 2019
3 Reads

Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors.

Nucl Med Biol 2018 Jul - Aug;62-63:18-30. Epub 2018 May 5.

Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.

Introduction: Radiolabeled, low-molecular-weight prostate-specific membrane antigen (PSMA) inhibitors based on the Glu-ureido pharmacophore show promise for the detection and treatment of castration-resistant prostate cancer; however, high renal retention of activity, related in part to overexpression of PSMA in kidneys can be problematic. The goal of the current study was to investigate the use of brush border enzyme-cleavable linkers as a strategy for reducing kidney activity levels from radiolabeled PSMA inhibitors.

Methods: PSMA-769 (6), a derivative of the prototypical PSMA inhibitor (((S)‑1‑carboxy‑5‑(4‑iodobenzamido)pentyl)carbamoyl)glutamate (12) modified to contain a Gly-Tyr linker, and its protected tin precursor (11) were synthesized starting from the basic pharmacophore molecule Lys-urea-Glu. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054815PMC
February 2019
4 Reads

Impact of structural alterations on the radiopharmacological profile of F-labeled pyrimidines as cyclooxygenase-2 (COX-2) imaging agents.

Nucl Med Biol 2018 Jul - Aug;62-63:9-17. Epub 2018 May 5.

Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, AB T6G 1Z2, Canada; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2H1, Canada. Electronic address:

Introduction: Non-invasive imaging of COX-2 in cancer represents a powerful tool for assessing COX-2-mediated effects on chemoprevention and radiosensitization using potent and selective COX-2 inhibitors as an emerging class of anticancer drugs. Careful assessment of the pharmacokinetic profile of radiolabeled COX-2 inhibitors is of crucial importance for the development of suitable radiotracers for COX-2 imaging in vivo. The delicate balance between the selection of typical COX-2 pharmacophores and the resulting physicochemical characteristics of the COX-2 inhibitor represents a formidable challenge for the search of radiolabeled COX-2 imaging agents. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.05.001DOI Listing
February 2019
2 Reads

The impact of age on radium-223 distribution and an evaluation of molecular imaging surrogates.

Nucl Med Biol 2018 Jul - Aug;62-63:1-8. Epub 2018 May 8.

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Johns Hopkins University School of Medicine, United States; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, United States. Electronic address:

Introduction: Radium-223 dichloride is the first alpha-particle emitting therapeutic agent approved by FDA and EMA for bone metastatic castration-resistant prostate cancer. We studied its age-dependent biodistribution in mice, and compared it with [Tc]Tc-MDP and [F]NaF aiming to identify a potential imaging surrogate to predict [Ra]RaCl whole-body localization.

Methods: Male C57Bl/6 mice dosed with [Ra]RaCl were sacrificed at different time points to explore [Ra]RaCl whole-body distribution. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054814PMC
February 2019
1 Read

Feasibility of myocardial PET imaging using a benzylguanidine analog: meta-(3-[F]fluoropropyl)benzylguanidine ([F]mFPBG).

Nucl Med Biol 2018 06 3;61:63-70. Epub 2018 May 3.

Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea; Center for Nanomolecular Imaging and Innovative Drug Development, Advanced Institutes of Convergence Technology, Suwon 16229, Republic of Korea; Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea.

Introduction: Global and regional sympathetic activity in the heart can be evaluated using [I]meta-iodobenzylguanidine ([I]mIBG) imaging. However, [I]mIBG is associated with low image spatial resolution and sensitivity in cardiac imaging. We investigated the capability of an F-18-labeled mIBG derivative, meta-(3-[F]fluoropropyl)benzylguanidine ([F]mFPBG), for identifying ischemic and viable myocardium in a rat model of myocardial infarction. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.04.005DOI Listing
June 2018
8 Reads

N-(4-[F]fluorobenzyl)cholylglycine, a novel tracer for PET of enterohepatic circulation of bile acids: Radiosynthesis and proof-of-concept studies in rats.

Nucl Med Biol 2018 06 4;61:56-62. Epub 2018 May 4.

Centre for Advanced Imaging, University of Queensland, St. Lucia, Brisbane, Australia.

Introduction: Enterohepatic circulation (EHC) of conjugated bile acids is an important physiological process crucial for regulation of intracellular concentrations of bile acids and their function as detergents and signal carriers. Only few bile acid-derived imaging agents have been synthesized and hitherto none have been evaluated for studies of EHC. We hypothesized that N-(4-[F]fluorobenzyl)cholylglycine ([F]FBCGly), a novel fluorine-18 labeled derivative of endogenous cholylglycine, would be a suitable tracer for PET of the EHC of conjugated bile acids, and we report here a radiosynthesis of [F]FBCGly and a proof-of-concept study by PET/MR in rats. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.04.004DOI Listing
June 2018
13 Reads

[F]-GE-179 positron emission tomography (PET) tracer for N-methyl-d-aspartate receptors: One-pot synthesis and preliminary micro-PET study in a rat model of MCAO.

Nucl Med Biol 2018 06 25;61:45-55. Epub 2018 Apr 25.

PET Center, Huashan Hospital, Fudan University, No. 518, East Wuzhong Road, Xuhui District, Shanghai 200235, China; Institute of Integrative Medicine, Fudan University, No. 12, Middle Urumqi Road, Jing'an District, Shanghai 200040, China. Electronic address:

Introduction: The objective of this study was to synthesize an N-methyl-d-aspartate receptor (NMDAR) radiotracer [F]-GE-179 in one-pot and evaluate its in vivo binding for NMDAR activation after brain ischemia reperfusion injury.

Methods: [F]-GE-179 was auto-synthesized using a quick one-pot method from a stable disulfide precursor and purified using semi-preparative high-performance liquid chromatography (HPLC) with ethanol/aqueous NaHPO as the eluent. Dynamic micro-positron emission tomography (PET)/computed tomography (CT) study of [F]-GE-179 was successfully performed using a rat model of middle cerebral artery occlusion (MCAO, induced by transient occlusion into the left MCA). Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.04.002DOI Listing
June 2018
2 Reads

Microscale radiosynthesis, preclinical imaging and dosimetry study of [F]AMBF-TATE: A potential PET tracer for clinical imaging of somatostatin receptors.

Nucl Med Biol 2018 06 20;61:36-44. Epub 2018 Apr 20.

Physics in Biology and Medicine Interdepartmental Graduate Program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center (JCCC), UCLA, Los Angeles, CA, USA. Electronic address:

Background: Peptides labeled with positron-emitting isotopes are emerging as a versatile class of compounds for the development of highly specific, targeted imaging agents for diagnostic imaging via positron-emission tomography (PET) and for precision medicine via theranostic applications. Despite the success of peptides labeled with gallium-68 (for imaging) or lutetium-177 (for therapy) in the clinical management of patients with neuroendocrine tumors or prostate cancer, there are significant advantages of using fluorine-18 for imaging. Recent developments have greatly simplified such labeling: in particular, labeling of organotrifluoroborates via isotopic exchange can readily be performed in a single-step under aqueous conditions and without the need for HPLC purification. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015542PMC
June 2018
6 Reads

Corrigendum to 'Pb-labeled B7-H3-targeting antibody for pancreatic cancer therapy in mouse models' [Nucl Med Biol 58 (2018) 67-73].

Nucl Med Biol 2018 06 25;61:71. Epub 2018 Apr 25.

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, United States.

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http://dx.doi.org/10.1016/j.nucmedbio.2018.03.004DOI Listing
June 2018
3 Reads

Development of a novel radiobromine-labeled sigma-1 receptor imaging probe.

Nucl Med Biol 2018 06 6;61:28-35. Epub 2018 Apr 6.

Graduate School of Medical Sciences, Kanazawa University, Kanazawa 920-1192, Japan.

Introduction: Sigma-1 receptor is a target for tumor imaging. In a previous study, we synthesized a vesamicol analog, (+)-2-[4-(4-bromophenyl)piperidino]cyclohexanol [(+)-pBrV], with a high affinity for sigma-1 receptor, and synthesized radiobrominated (+)-pBrV. This radiobrominated (+)-pBrV showed high tumor uptake in tumor-bearing mice; however, radioactivity accumulation in normal tissues, such as the liver, was high. Read More

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June 2018
3 Reads

Imaging thrombosis with Tc-labeled RAM.1-antibody in vivo.

Nucl Med Biol 2018 06 17;61:21-27. Epub 2018 Mar 17.

Université de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France.

Introduction: Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.03.003DOI Listing
June 2018
2 Reads

Preliminary evaluation of F-labeled LLP2A-trifluoroborate conjugates as VLA-4 (αβ integrin) specific radiotracers for PET imaging of melanoma.

Nucl Med Biol 2018 06 12;61:11-20. Epub 2018 Mar 12.

Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada. Electronic address:

Introduction: The transmembrane αβ integrin receptor, or very-late antigen 4 (VLA-4), is associated with tumor metastasis and angiogenesis, the development of chemotherapeutic drug resistance, and is overexpressed in multiple myelomas, osteosarcomas, lymphomas, leukemias, and melanomas. The peptidomimetic, LLP2A, is a high-affinity ligand with specificity for the extracellular portion of VLA-4 and several conjugates have been evaluated in vivo by NIR-fluorescence, In-SPECT and Ga- and Cu-PET imaging, but to date, not with F-PET.

Methods: Using two highly stable organotrifluoroborate prosthetic groups: ammoniumdimethyl-trifluoroborate (AMBF) and a new N-pyridinyl-para-trifluoroborate (N-Pyr-p-BF), both capable of facile aqueous F-labeling by isotope exchange (IEX), we present the first PET imaging evaluations of two [F]R-BF-PEG-LLP2A tracers using VLA-4 overexpressing B16-F10 murine melanoma tumor mouse models. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.02.005DOI Listing
June 2018
6 Reads

Robust high-yield ~1 TBq production of cyclotron based sodium [Tc]pertechnetate.

Nucl Med Biol 2018 05 2;60:63-70. Epub 2018 Mar 2.

University of Alberta, Medical Isotope and Cyclotron Facility, Department of Oncology, Edmonton, AB, Canada.

This paper presents the irradiation and processing of high-current Mo targets at the University of Alberta (UofA) in a GMP compliant setting. For purpose of comparison with a second production facility, additional studies at Centre Hospitalier Universitaire de Sherbrooke (CHUS) are also described.

Introduction: More than 70% of today's diagnostic radiopharmaceuticals are based on Tc, however the conventional supply chain for obtaining Tc is fragile. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.02.003DOI Listing
May 2018
8 Reads

Evaluation of Lu[Lu]-CHX-A″-DTPA-6A10 Fab as a radioimmunotherapy agent targeting carbonic anhydrase XII.

Nucl Med Biol 2018 05 4;60:55-62. Epub 2018 Mar 4.

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany. Electronic address:

Introduction: Due to their infiltrative growth behavior, gliomas have, even after surgical resection, a high recurrence tendency. The approach of intracavitary radioimmunotherapy (RIT) is aimed at inhibiting tumor re-growth by directly administering drugs into the resection cavity (RC). Direct application of the radioconjugate into the RC has the advantage of bypassing the blood-brain barrier, which allows the administration of higher radiation doses than systemic application. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2018.02.004DOI Listing
May 2018
2 Reads