5,214 results match your criteria Nuclear Medicine Communications[Journal]


Spatial dependence of activity concentration recovery for a conjugate gradient (Siemens xSPECT) algorithm using manufacturer-defined reconstruction presets.

Authors:
Ian S Armstrong

Nucl Med Commun 2019 Mar;40(3):287-293

Nuclear Medicine Centre, Manchester University NHS Foundation Trust, Manchester, UK.

Siemens absolute quantitative reconstruction, xSPECT, is available with manufacturer-defined reconstruction presets to assist with optimization. This phantom study evaluates the impact of these presets on the spatial dependence of activity concentration recovery (ACR). Single-photon emission computed tomography/computed tomography scans of a 5 : 1 and 10 : 1 (sphere : background) contrast NEMA phantom were performed on a Siemens Intevo 6. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000960DOI Listing
March 2019
1.371 Impact Factor

Synthesis and preclinical evaluation of the 177Lu-DOTA-PSMA(inhibitor)-Lys3-bombesin heterodimer designed as a radiotheranostic probe for prostate cancer.

Nucl Med Commun 2019 Mar;40(3):278-286

Facultad de Medicina.

Backround: Human tumors show intrinsic heterogeneity and changes in phenotype during disease progression, which implies different expression levels of cell surface receptors. The research on new heterodimeric lutetium-177 (Lu)-radiopharmaceuticals interacting with two different targets on tumor cells is a strategy for improvement of radiotheranostic performance. This study aimed to synthesize and characterize the Lu-DOTA-PSMA(inhibitor)-Lys-bombesin (Lu-DOTA-iPSMA-Lys-BN) heterodimer and to evaluate its potential to target prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPr) overexpressed in prostate cancer. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000966DOI Listing

Usefulness of respiratory-gated 18F-FDG PET/CT scan protocol in patients having positive myocardial 18F-FDG uptake.

Nucl Med Commun 2019 Mar;40(3):235-241

Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University Hospital.

Objective: The aim of this study were to estimate the influence of respiratory movement on the fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) imaging of patients having positive myocardial F-FDG uptake and to demonstrate an adequate respiratory-gated F-FDG PET/CT scan protocol.

Materials And Methods: An anthropomorphic chest phantom containing a cardiac ventricle phantom was filled with an fluorine-18 solution and scanned in both a nonmoving state and a moving state with respiratory gating. In the nonmoving state, PET images were acquired in static mode (static PET), whereas in the moving state, PET images were acquired in a nongated mode (nongated PET), and in a gated mode (gated PET). Read More

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http://dx.doi.org/10.1097/MNM.0000000000000947DOI Listing

Quantitative analysis of technetium-99m-sestamibi uptake and washout in parathyroid scintigraphy supports dual mechanisms of lesion conspicuity.

Nucl Med Commun 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine, Division of Nuclear Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Purpose: Proposed mechanisms of parathyroid localization in 'dual-phase' technetium-99m-sestamibi imaging include increased presence of mitochondria leading to greater uptake and slower washout compared with thyroid tissues owing to reduced expression of P-glycoprotein. Using new techniques of quantitative single-photon emission computed tomography (SPECT)/computed tomography (CT), we have measured MIBI uptake and washout to better understand factors related to conspicuity.

Patients And Methods: We retrospectively reviewed 125 consecutive patients. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000996DOI Listing
February 2019

Time trend analysis of pulmonary embolism diagnosis with single-photon emission computed tomography ventilation/perfusion imaging.

Nucl Med Commun 2019 Feb 7. Epub 2019 Feb 7.

Department of Nuclear Medecine.

Objective: Following the implementation of single-photon emission computed tomography ventilation/perfusion (SPECT V/Q) in our department, we previously carried out an observational study over the period 2011-2013 that showed the safety of SPECT V/Q to rule out pulmonary embolism (PE). However, PE prevalence (28%) was high compared with some studies. Our hypothesis was that the use of SPECT V/Q may be responsible for an overdiagnosis of PE, especially at the implementation phase of the test. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000990DOI Listing
February 2019
1 Read

Evaluation of cyclic direct radionuclide cystography findings with DMSA scintigraphy results in children with a prior diagnosis of vesicoureteral reflux.

Nucl Med Commun 2019 Feb 7. Epub 2019 Feb 7.

Department of Nuclear Medicine, Adana Teaching and Medical Research Center, Faculty of Medicine, Baskent University, Ankara, Turkey.

Objectives: Direct radionuclide cystography (DRC) with cyclic imaging is a sensitive method used for the detection of vesicoureteral reflux (VUR). Radionuclide cystography is generally recommended for follow-up evaluation of VUR. The aim of this study was to evaluate cyclic DRC with DMSA scan results during the follow-up period in children with a prior diagnosis of VUR. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000994DOI Listing
February 2019
1 Read

Radiochemical purity of technetium-99m-nanocolloid rhenium sulphide is not influenced by heating.

Nucl Med Commun 2019 Jan 31. Epub 2019 Jan 31.

Radiopharmacy Unit, Departement of Pharmacy, Groupement Hospitalier Est, Hospices Civils de Lyon, 59 boulevard Pinel, 69677 Bron Cedex.

Despite a mistake during the preparation of technetium-99m (Tc)-nanocolloid rhenium sulphide (Nanocis) because of lack of heating, the apparent radiochemical purity (RCP) of this product was correct. The objectives of this study were to evaluate the impact of absence of heating on the RCP of Tc-nanocolloid rhenium sulphide and the effect of heating on particle size. Five Tc-Nanocis were prepared according to the manufacturer's instructions and five others were realized without any heating step. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000988DOI Listing
January 2019

Diagnostic value of adrenal iodine-131 6-beta-iodomethyl-19-norcholesterol scintigraphy for primary aldosteronism: a retrospective study at a medical center in North Taiwan.

Nucl Med Commun 2019 Jan 28. Epub 2019 Jan 28.

Department of Internal Medicine, Division of Endocrinology and Metabolism, College of Medicine.

Background: Primary aldosteronism (PA) is a common cause of secondary hypertension. Among the many leading causes of PA, the two most frequent are, bilateral adrenal hyperplasia (BAH) and aldosterone-producing adenomas (APA). Since a solitary APA may be cured surgically, but BAH needs lifelong pharmacologic therapy, confirmation is mandatory before surgery. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000987DOI Listing
January 2019
2 Reads

Comparison of (18F)FDG PET/CT and (68Ga)DOTATATE PET/CT imaging methods in terms of detection of histological subtype and related SUVmax values in patients with pulmonary carcinoid tumors.

Nucl Med Commun 2019 Jan 28. Epub 2019 Jan 28.

Department of Nuclear Medicine, Diyarbakir Gazi Yasargil Training and Research Hospital.

Objective: This study was designed to compare the 18-Fluorodeoxyglucose positron emission tomography/computed tomography [(F)FDG PET/CT] and 1,4,7,10-tetraazacyclododecane-NI,NII,NIII,NIIII-tetraacetic acid (D)-Phe1-thy3-octreotate [(Ga)DOTATATE PET/CT) findings in patients with pulmonary carcinoid (PC) tumors.

Materials And Methods: A total of 20 patients [mean (SD) age: 52.2 (12. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000985DOI Listing
January 2019
3 Reads

Correlation of fluorine 18-labeled sodium fluoride uptake and arterial calcification on whole-body PET/CT in cancer patients.

Nucl Med Commun 2019 Jan 25. Epub 2019 Jan 25.

Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Fluorine-18-labeled sodium fluoride (F-NaF) uptake measured with PET in the vessel walls can indicate active microcalcification, a potential biomarker of higher-risk plaques, which are not indicated by macrocalcification measured with computed tomography (CT). The aim of this study was to determine the extent to which F-NaF uptake is correlated with calcification at arterial plaques in cancer patients undergoing whole-body PET/CT imaging.

Patients And Methods: Image data from 179 patients who underwent F-NaF PET/CT were evaluated retrospectively. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000986DOI Listing
January 2019

Stress test of liver function using technetium-99m-mebrofenin hepatobiliary scintigraphy.

Nucl Med Commun 2019 Jan 22. Epub 2019 Jan 22.

Radiology and Nuclear Medicine.

Technetium-99m (Tc) mebrofenin hepatobiliary scintigraphy (HBS) enables a quantitative assessment of liver function. This is normally performed in a fasting state and might therefore reflect the resting liver function. We evaluated the change in liver function using HBS after stimulation with an oral metabolic challenge. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000979DOI Listing
January 2019

Impact of hibernating and viable myocardium on improvement in perfusion and left ventricular ejection fraction after coronary artery bypass graft.

Nucl Med Commun 2019 Jan 22. Epub 2019 Jan 22.

Nuclear Medicine.

Objectives: The association between the extent and degree of perfusion-metabolism mismatch and improvement in perfusion and left ventricular ejection fraction (LVEF) after revascularization was assessed. The secondary aim was to identify the best precoronary artery bypass graft surgery (pre-CABG) PET parameter, if any, to predict the improvement in the perfusion and LVEF after CABG.

Methods And Results: Overal, 31 patients (mean age: 58+8. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000976DOI Listing
January 2019

An investigation into the accuracy of using serum creatinine estimated glomerular filtration rate to predict measured glomerular filtration rate.

Nucl Med Commun 2019 Jan 21. Epub 2019 Jan 21.

Departments of Radiation Physics and Protection.

Objectives: The aim of the study was to identify a threshold value of the estimated glomerular filtration rate (eGFR) that would predict a measured glomerular filtration rate (mGFR) of ≤25 ml/min/1.73 m. This is to guide use of the new British Nuclear Medicine Society guidelines, which specifies a 24 h sample for patients with a GFR of ≤25 ml/min/1. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000980DOI Listing
January 2019

18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications.

Nucl Med Commun 2019 Jan 18. Epub 2019 Jan 18.

Nuclear Medicine Department, Lady Davis Institute, Jewish General Hospital.

Background: To compare the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) and conventional tests for cancer screening in autoimmune inflammatory myopathy (AIM) patients.

Patients And Methods: We carried out a retrospective cohort study of AIM patients from one academic center in Montreal, Canada, classified using myositis-specific antibodies, who underwent F-FDG PET/CT between April 2005 and February 2018 and were followed up on average 3.5±2. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000981DOI Listing
January 2019
5 Reads

Amersham radiopharmaceuticals: a global scientific and industrial legacy for nuclear medicine.

Authors:
Alan C Perkins

Nucl Med Commun 2019 Mar;40(3):191-193

Department of Radiological Sciences, School of Medicine, Medical Physics and Clinical Engineering, Nottingham University Hospitals, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1097/MNM.0000000000000984DOI Listing

Propagation of measurement errors in glomerular filtration rate determination: a comparison of slope-intercept, single-sample and slope-only methods.

Nucl Med Commun 2019 Jan 18. Epub 2019 Jan 18.

Department of Medical Imaging and Clinical Oncology, Nuclear Medicine Division, Stellenbosch University.

Background: Measurement errors occurring during glomerular filtration rate (GFR) studies propagate to an error in the calculated GFR. Previous work has modelled measurement errors for slope-intercept (SI-GFR), single-sample (SS-GFR) and slope-only (SO-GFR) methods. In this study, we have extended these models. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000977DOI Listing
January 2019
1 Read
1.371 Impact Factor

Prognostic value of 18F-FDG PET/CT functional parameters in patients with head and neck cancer: a meta-analysis.

Nucl Med Commun 2019 Jan 18. Epub 2019 Jan 18.

Chengdu First People's Hospital, Hi-Tech Zone, Chengdu, People's Republic of China.

Purpose: We performed this meta-analysis to evaluate the prognostic value of maximum of standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) in patients with head and neck cancer.

Methods: Articles including prognostic value of PET/CT were searched in PubMed and subsequently analyzed. The primary outcome of interest was event-free survival, and the secondary outcome of interest was overall survival. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000974DOI Listing
January 2019
1.371 Impact Factor

Significance of the preoperative regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the future remnant liver: a sequential study of regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the whole liver.

Nucl Med Commun 2019 Feb;40(2):145-152

Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki.

Background: The relationship between posthepatectomy complications and liver functional parameters was preliminary reported in a pilot study. The present study sequentially evaluated the clinical significance of maximal removal rate of technetium-99m-galactosyl human serum albumin (GSARmax) in the future remnant liver (rGSARmax) in patients to predict posthepatectomy complications.

Methods: Between 2010 and August 2017, GSARmax, rGSARmax, their difference (Dif), and the rGSARmax to GSARmax ratio were examined in 247 additional patients who underwent hepatectomy for liver and biliary diseases. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000950DOI Listing
February 2019
1 Read

2015 UK software audit of hepatobiliary scintigraphy.

Nucl Med Commun 2019 Feb;40(2):136-144

St Luke's Hospital, Dublin, Ireland.

Introduction: This audit investigated hepatobiliary function imaging in UK hospitals, reviewing protocol differences in acquisition and processing parameters and the effect on calculated gallbladder ejection fraction (GBEF).

Participants And Methods: Two dynamic data sets were available: one continuous dynamic data set, and the other with a 5-min break to administer the fatty stimulus. Participants used a set of 12 anonymized patient data sets most similar to their standard protocol calculating GBEF using their routine method. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000948DOI Listing
February 2019

Challenges using PET-CT for international multicentre coordinated research projects in developing countries.

Nucl Med Commun 2019 Feb;40(2):93-95

Nuclear Medicine Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.

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http://dx.doi.org/10.1097/MNM.0000000000000958DOI Listing
February 2019

18F-FDG PET/CT and nestin expression as prognostic tools in pulmonary neuroendocrine tumours.

Nucl Med Commun 2019 Jan 10. Epub 2019 Jan 10.

Departments of Endocrinology, Metabolism and Internal Medicine.

Objectives: The aim of this study was to investigate the fluorine-18-fluorodeoxyglucose (F-FDG) uptake on integrated PET [PET/computed tomography (CT)] images and its correlation with nestin expression in a series of neuroendocrine lung tumours. As the incidence of neuroendocrine lung tumours is rising, tools predicting diagnosis, outcome and assisting in the selection of treatment regimens are needed.

Patients And Methods: We reviewed records of patients diagnosed with large cell neuroendocrine lung carcinoma, atypical carcinoid and typical carcinoid who were operated upon in our institution. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000972DOI Listing
January 2019

Relationship between regional hepatic glucose metabolism and regional distribution of hepatic fat.

Nucl Med Commun 2019 Mar;40(3):212-218

Brighton and Sussex University Hospitals NHS Trust.

Aim: Hepatic steatosis is associated with insulin resistance and hyperinsulinaemia. Insulin stimulates hepatic glucokinase, even in insulin resistance, so hepatic glucose uptake is increased in hepatic steatosis. The study hypothesis was that hepatic glucose uptake is also influenced locally by fat, the hepatic distribution of which is heterogeneous. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000968DOI Listing
March 2019
8 Reads

The relationship between thyroid eye disease and radioiodine treatment.

Nucl Med Commun 2019 Mar;40(3):194-198

Department of Nuclear Medicine, National Cancer Center, Calmette University Hospital, Phnom Penh, Cambodia.

Thyroid eye disease is the most frequent extrathyroidal manifestation of Graves' disease and it can have a major negative impact on the quality of life of affected patients. Therefore, it is crucial to have a correct and early diagnosis. Thyroid eye disease management should be multidisciplinary. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000965DOI Listing
March 2019
4 Reads

Parotid incidentalomas on positron emission tomography: what is their clinical significance?

Nucl Med Commun 2019 Mar;40(3):264-269

Norwich Radiology Academy, The Cotman Centre, Norwich.

Objective And Aim: The increased use of PET/CT in cancer staging has resulted in more incidental findings in unexpected locations, making this a challenge for the radiologist interpreting the study. Our aim was to determine the frequency of parotid incidentalomas and to assess the ability of PET/CT to characterize them.

Patients And Methods: At the Norfolk and Norwich University Trust, in between October 2010 to October 2015, 4044 patients had a PET/CT examination. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000961DOI Listing
March 2019
1 Read

Medical nuclomics: a new order in nuclear medicine practice.

Authors:
Issa Loutfi

Nucl Med Commun 2019 Mar;40(3):294-296

Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.

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http://dx.doi.org/10.1097/MNM.0000000000000975DOI Listing

Practical guidelines for the use of technetium-99m mebrofenin hepatobiliary scintigraphy in the quantitative assessment of liver function.

Nucl Med Commun 2018 Dec 28. Epub 2018 Dec 28.

Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, The Netherlands.

Surgical resection remains the most important curative treatment for liver tumors; however, it harbors the risk of developing posthepatectomy liver failure. The principal risk is associated with the quality and quantity of the future remnant liver. Therefore, preoperative assessment of the future remnant liver is essential in patients scheduled for major liver resection. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000973DOI Listing
December 2018

Predictive risk factors for sentinel lymph node nonvisualization on planar lymphoscintigraphy using an intratumoral injection in patients with primary breast cancer.

Nucl Med Commun 2018 Dec 28. Epub 2018 Dec 28.

Departments of Nuclear Medicine.

Objectives: Lymphoscintigraphy is considered a useful tool to optimize sentinel lymph node (SLN) identification. Nonvisualization of the SLN is associated with a lower SLN identification rate. The aim of this study was to identify preoperative factors associated with SLN nonvisualization on lymphoscintigraphy. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000971DOI Listing
December 2018
1 Read

Denoising of iodine-131 images using a median filter.

Nucl Med Commun 2018 Dec 26. Epub 2018 Dec 26.

Department of Nuclear Medicine, All India Institute of Medical Sciences.

Objective: An iodine-131 (I) image visually appears to be contaminated with impulse noise. The two-dimensional median filter removes noise without sacrificing the edge information. Its performance depends on the shape and size of the mask. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000970DOI Listing
December 2018
1.371 Impact Factor

The efficacy of pretreatment and after treatment 18F-FDG PET/CT metabolic parameters in patients with locally advanced squamous cell cervical cancer.

Nucl Med Commun 2019 Mar;40(3):219-227

Department of Nuclear Medicine, Istanbul Training and Research Hospital.

Objectives: Cervical cancer is one of the main causes of cancer death worldwide. Fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (PET/CT) has been playing an increasingly important role in staging and monitoring treatment response in the disease. In the current study, we investigated metabolic F-FDG PET/CT parameters among patients with locally advanced squamous cell cervical cancer treated with concurrent chemoradiotherapy for predicting disease-free survival (DFS). Read More

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http://dx.doi.org/10.1097/MNM.0000000000000969DOI Listing
March 2019
1 Read

Development and validation of a new method to diagnose apical hypertrophic cardiomyopathy by gated single-photon emission computed tomography myocardial perfusion imaging.

Nucl Med Commun 2019 Mar;40(3):206-211

School of Computing, University of Southern Mississippi, Long Beach, Mississippi, USA.

Aim: The aim of this study is to develop and validate a new method to diagnose apical hypertrophic cardiomyopathy (AHCM) by the integral quantitative analysis of myocardial perfusion and wall thickening from gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).

Patients And Methods: Twenty-two consecutive patients, who showed T wave inversion of at least 3 mm in precordial leads and sinus rhythm in ECG, were enrolled. All the patients underwent cardiac magnetic resonance (CMR), gated rest SPECT MPI and echocardiography. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000967DOI Listing
March 2019
2 Reads
1.371 Impact Factor

First comparative results about the direct effect of traditional cigarette and e-cigarette smoking on lung alveolocapillary membrane using dynamic ventilation scintigraphy.

Nucl Med Commun 2019 Feb;40(2):153-158

Scanomed Ltd.

Introduction: Dynamic inhalation scintigraphy (DIS) with technetium-99m-diethylenetriamine-pentaacetate aerosol is a useful nuclear medicine procedure for staging and monitoring the damage of alveolocapillary membrane. The e-cigarette is a new popular smoking device producing vapor from the nicotine solution. Many studies have shown that e-cigarettes appear to be safer than smoking, but there are still debates to what extent e-cigarettes are less harmful than smoking. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000957DOI Listing
February 2019
3 Reads

Incidence and severity of femoral head avascularity after femoral neck or intertrochanteric fractures on preoperative bone single photon emission computed tomography/computed tomography: preliminary study.

Nucl Med Commun 2019 Mar;40(3):199-205

Department of Nuclear Medicine, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Cyclotron Research Center, Molecular Imaging and Therapeutic Medicine Research Center, Chonbuk National University Medical School and Hospital.

Objective: The aim of the present study was to evaluate the incidence and degree of femoral head avascularity depending on the types of femoral neck or intertrochanteric fractures using preoperative bone single photon emission computed tomography (SPECT)/computed tomography (CT).

Patients And Methods: A total of 131 patients with femoral neck or intertrochanteric fractures who underwent preoperative bone SPECT/CT were enrolled. Femoral head avascularity was evaluated using bone SPECT/CT images. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000963DOI Listing
March 2019
2 Reads

Effect of positive carbon-11-choline PET/CT results in the therapeutic management of prostate cancer biochemical relapse.

Nucl Med Commun 2019 Jan;40(1):79-85

Department of Nuclear Medicine, Marqués de Valdecilla University Hospital, Molecular Imaging Group (IDIVAL), University of Cantabria, Santander, Spain.

Objective: Carbon-11-(C)-choline PET/computed tomography (CT) has shown good results in re-staging of prostate cancer (PCa) with raised serum levels of prostate-specific antigen. Our aim was to evaluate the effect of positive C-choline PET/CT results in the therapeutic management of patients with PCa with biochemical relapse (BR) after curative intention treatment.

Patients And Methods: A total of 112 patients with PCa BR and positive C-choline PET/CT were retrospectively evaluated. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282669PMC
January 2019
2 Reads

The appropriate whole body metric for calculating standardised uptake value and the influence of sex.

Nucl Med Commun 2019 Jan;40(1):3-7

Brighton and Sussex Medical School, Brighton.

Aim: To compare weight, lean body mass and body surface area for calculation of standardised uptake value (SUV) in fluorine-18-fluorodeoxyglucose PET/computed tomography, taking sex into account.

Patients And Methods: This was a retrospective study of 161 (97 men) patients. Maximum standardised uptake value (SUVmax) and mean standardised uptake value (SUVmean) were obtained from a 3-cm region of interest over the right lobe of the liver and scaled to weight, scaled to lean body mass (SUL) and scaled to body surface area (SUA). Read More

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http://dx.doi.org/10.1097/MNM.0000000000000935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282933PMC
January 2019
1 Read

The use of single-photon emission computed tomography-computed tomography in detecting multiple metastatic lymph nodes in patients with breast cancer.

Nucl Med Commun 2019 Feb;40(2):169-174

Department of Medico-biological Science, North-West State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia.

Aim: The aim of the present study was to determine the accuracy of single-photon emission computed tomography-computed tomography (SPECT-CT) with technetium-99m-sestamibi (Tc-MIBI) for detecting multiple (>2 nodes) axillary lymph node involvement in patients with breast cancer (BC).

Patients And Methods: A total of 184 women with BC were examined. Clinically, axillary lymph nodes were classified as N0 in all cases. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000954DOI Listing
February 2019
11 Reads

Sensitivity of fluorine-18-fluoromethylcholine PET/CT to prostate-specific antigen over different plasma levels: a retrospective study in a cohort of 192 patients with prostate cancer.

Nucl Med Commun 2019 Mar;40(3):258-263

Department of Nuclear Medicine, Sant'Andrea Hospital, La Spezia.

Purpose: Several factors have been identified that predict positive fluorine-18-fluoromethylcholine (F-FCH) PET/CT result in patients with prostate cancer undergoing PET/CT for biochemical failure. Among these factors, prostate-specific antigen (PSA) is the single factor most consistently associated with the prediction of positive F-FCH PET/CT. In this study, we wished to confirm this finding and expand it in a large series of patients. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000959DOI Listing
March 2019
1 Read

Classification of amyloid PET images using novel features for early diagnosis of Alzheimer's disease and mild cognitive impairment conversion.

Nucl Med Commun 2019 Mar;40(3):242-248

Department of Engineering Science, University of Oxford, Oxford.

Background: New PET tracers could have a substantial impact on the early diagnosis of Alzheimer's disease (AD), particularly if they are accompanied by optimised image analysis and machine learning methods. Fractal dimension (FD) analysis, a measure of shape complexity, has been proven useful in MRI but its application to fluorine-18 amyloid PET has not yet been demonstrated. Shannon entropy (SE) has also been proposed as a measure of image complexity in DTI imaging, but it is not yet widely used in radiology. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000953DOI Listing
March 2019
1 Read

Discovery Molecular Imaging Digital Ready PET/CT performance evaluation according to the NEMA NU2-2012 standard.

Nucl Med Commun 2019 Mar;40(3):270-277

University Hospital Southampton NHS Foundation Trust, Southampton.

Objectives: The aim of this study was to evaluate and benchmark the performance characteristics of the General Electric (GE) Discovery Molecular Imaging (MI) Digital Ready (DR) PET/CT.

Materials And Methods: Performance evaluation against the National Electrical Manufacturers Association (NEMA) 2012 standard was performed on three GE Discovery MI DR PET/CT systems installed across different UK centres. The Discovery MI DR performance was compared with the Siemens Biograph mCT Flow, Phillips Ingenuity TF and GE Discovery 690 fully analogue PET/CT systems. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000962DOI Listing

Celiac ganglia: can they be misinterpreted on multimodal 68Ga-PSMA-11 PET/MR?

Nucl Med Commun 2019 Feb;40(2):175-184

Department of Nuclear Medicine, The Franciszek Lukaszczyk Oncology Centre.

Objective: The objective of this study was to investigate the morphologic features and Ga-prostate-specific membrane antigen (PSMA)-11 avidity of celiac ganglia (CG) on multimodal PET/MRI.

Materials And Methods: Ga-PSMA-11 whole-body PET/MR examinations in 120 patients, referred for staging or follow-up of prostate cancer, were retrospectively reviewed to investigate the radiotracer uptake [maximum standardized uptake value (SUVmax)] and morphologic features (size, shape, location) of CG. Nodular, oval and longitudinal nodular, thick or with oval parts shapes of CG were regarded as mistakable with lymph nodes, whereas linear and longitudinal shapes were considered as not mistakable. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000944DOI Listing
February 2019
12 Reads

Evaluating the potential of kit-based 68Ga-ubiquicidin formulation in diagnosis of infection: a pilot study68Ga.

Nucl Med Commun 2019 Mar;40(3):228-234

Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Chandigarh.

Objective: The aim was to evaluate the diagnostic potential of Ga-ubiquicidin positron-emission tomography/computed tomography (PET/CT) in imaging patients with infection.

Materials And Methods: Ga-NOTA-ubiquicidin (Ga-UBI) was prepared by addition of freshly eluted Ga-chloride from Ge/Ga generator into the NOTA-ubiquicidin vial and incubated at room for 15 min at 90°C. After compounding of the radiopharmaceutical, quality control using instant thin-layer chromatography, culture and endotoxin estimation was performed. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000943DOI Listing
March 2019
16 Reads
1.371 Impact Factor

Quantitative assessment of 18F-FDG PET in patients with Hodgkin lymphoma: is it significantly affected by contrast-enhanced computed tomography attenuation correction?

Nucl Med Commun 2019 Mar;40(3):249-257

Departments of Nuclear Medicine.

Objective: The reliability of visual and quantitative response assessment may be impaired owing to inconsistent scanning protocols and image reconstruction methods of 2-deoxy-2-[F]fluoro-D-glucose (F-FDG) PET. Hence, this study investigates the effect of contrast-enhanced computed tomography (CT) attenuation correction in patients with Hodgkin lymphoma.

Patients And Methods: In 10 consecutive patients undergoing either staging or response assessment, F-FDG PET images were attenuation-corrected once on the basis of unenhanced CT and additionally using contrast-enhanced CT. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000956DOI Listing
March 2019
3 Reads

Influence of myocardial count on phase dyssynchrony analysis of gated myocardial perfusion single-photon emission computed tomography.

Nucl Med Commun 2019 Feb;40(2):124-130

Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui.

Objectives: Drugs and acquisition times for gated myocardial perfusion single-photon emission computed tomography scintigraphy vary depending on the facility. Even if the same examination is performed in the same facility, the acquisition count differs for each examination because factors such as the patient's age, stress protocol of the patient, the biological half-life of the stress agent, and the patient's response are different. We aimed to evaluate the differences in acquisition counts on the effect of left ventricular function and phase analysis indices. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000949DOI Listing
February 2019
10 Reads

The synthesis of a new macromolecule for the sentinel node detection: 99mTc-gly-mannosyl-dextran.

Nucl Med Commun 2019 Feb;40(2):131-135

Key Laboratory of Nuclear Medicine, Ministry of Health, Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China.

Objective: We aimed to design and synthesize a new macromolecule for sentinel node detection to improve the imaging quality and avoid possible adverse effect.

Background: The imaging of sentinel lymph node has been an important field in the nuclear medicine. A lot of imaging agents have been developed, including Tc-sulfer colloid, Tc-labeled dextrans and the latest Tc-DTPA-mannosyl-dextran. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000951DOI Listing
February 2019
19 Reads

Assessment of therapeutic effects of statin on cardiac sympathetic nerve activity and cardiac events in patients with ischemic cardiomyopathy and mild to moderate heart failure.

Nucl Med Commun 2019 Feb;40(2):159-168

Institute for Clinical and Translational Science, Nara Medical University Hospital, Kashihara, Nara.

Introduction: We determined whether statin therapy improved cardiac sympathetic nerve activity as evaluated using iodine-123-metaiodobenzylguanidine (I-MIBG) scintigraphy, and whether this therapy affects prognosis in patients with ischemic cardiomyopathy.

Patients And Methods: This study was a subanalysis of our previous report of the result that the serial I-MIBG scintigraphic studies were the most useful prognostic indicator in patients with heart failure. Patients with heart failure [left ventricular ejection fraction (LVEF) <45%] but no cardiac events for at least 5 months before the study were identified according to their history of decompensated acute heart failure requiring hospitalization. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000955DOI Listing
February 2019
9 Reads

Choline PET/CT in parathyroid imaging: a systematic review.

Nucl Med Commun 2019 Feb;40(2):96-105

Department of Nuclear Medicine, Northwest Clinics, Alkmaar, The Netherlands.

One of the most promising imaging techniques in primary hyperparathyroidism is PET/CT with choline-based tracers. To investigate the current evidence of these tracers in localizing parathyroid adenoma, a systematic review was performed. A comprehensive literature search was carried out and eligible studies were analyzed. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000952DOI Listing
February 2019
2 Reads

Fluorine-18-fluorodeoxyglucose positron emission tomography in thyroid nodules with indeterminate cytology: a prospective study.

Nucl Med Commun 2019 Feb;40(2):185-187

Santa Casa de Belo Horizonte, Belo Horizonte, Brazil.

Background: Up to 20% of thyroid nodules subjected to fine-needle aspiration exhibit indeterminate cytology. The rate of malignancy in these nodules ranges from 10 to 40%. The objective of this prospective study was to evaluate the utility of fluorine-18-fluorodeoxyglucose (F-FDG) PET in nonautonomous thyroid nodules of more than 1 cm whose cytology is indeterminate (Bethesda categories III or IV) and that are not highly suspicious on ultrasonography. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000946DOI Listing
February 2019
7 Reads

Pituitary 18F-FDG uptake correlates with serum TSH levels in thyroid cancer patients on 18F-FDG PET/CT.

Nucl Med Commun 2019 Jan;40(1):57-62

Department of Nuclear Medicine, XinHua Hospital, School of Medicine, Shanghai Jiaotong University.

Objective: The objective of this study was to evaluate the relationship between fluorine-18-fluorodeoxyglucose (F-FDG) uptake in the pituitary gland and serum thyroid-stimulating hormone (TSH) levels in differentiated thyroid cancer (DTC) patients on F-FDG PET/computed tomography (CT).

Patients And Methods: A total of 215 DTC patients and 215 age-paired and sex-paired healthy screening participants were included. DTC patients were divided into hypothyroid, euthyroid and subclinical hyperthyroid patients according to their serum TSH levels. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282667PMC
January 2019
14 Reads

Myocardial perfusion imaging detects mechanical dyssynchrony in left ventricular infarcted and noninfarcted areas early after acute myocardial infarction in a porcine model.

Nucl Med Commun 2019 Feb;40(2):115-123

Departments of Nuclear Medicine.

Background: Left ventricular mechanical dyssynchrony (LVMD) is closely associated with left ventricular dysfunction and poor prognosis in patients with acute myocardial infarction (AMI). However, whether mechanical dyssynchrony is present in the noninfarcted areas remains controversial. This research aimed to quantitatively evaluate the global and regional mechanical dyssynchrony early after AMI by phase analysis of single-photon emission computed tomography (SPECT) gated myocardial perfusion imaging (GMPI) and to further explore the related influencing factors. Read More

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http://Insights.ovid.com/crossref?an=00006231-900000000-9848
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http://dx.doi.org/10.1097/MNM.0000000000000945DOI Listing
February 2019
10 Reads

Diastolic dysfunction can precede systolic dysfunction on MUGA in cancer patients receiving trastuzumab-based therapy.

Nucl Med Commun 2019 Jan;40(1):22-29

Department of Nuclear Medicine, The Ottawa Hospital.

Background: Trastuzumab (T) and anthracycline (A)-based chemotherapy is considered the standard of care in human epidermal growth factor receptor-2+ overexpressing breast cancer, but requires monitoring for known cardiotoxicity using left ventricular (LV) ejection fraction (EF) every 3-4 months during treatment. It is not conclusively established whether diastolic dysfunction (DD) precedes LVEF decrease in patients developing trastuzumab-induced cardiotoxicity (TIC).

Objective: The aim was to elucidate whether DD precedes LVEF decrease in trastuzumab-treated patients being monitored with radionuclide multigated acquisition for TIC. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282666PMC
January 2019
12 Reads

Can SUVmax values of Ga-68-PSMA PET/CT scan predict the clinically significant prostate cancer?

Nucl Med Commun 2019 Jan;40(1):86-91

Department of Urology, Acıbadem University Medical Faculty, Istanbul, Turkey.

Purpose: The intensity of prostate-specific membrane antigen (PSMA) expression increases as the tumor grade increases and the uptake of Ga-68-PSMA is higher in high-grade tumors. The aim of the present study was to evaluate the correlation of preoperative tracer uptake of primary tumor to Gleason Score in patients who underwent prostatectomy.

Patients And Methods: We retrospectively evaluated 141 patients who had Ga-68-PSMA positron emission tomography/computed tomography (PET/CT) imaging and who underwent prostatectomy. Read More

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http://Insights.ovid.com/crossref?an=00006231-900000000-9848
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http://dx.doi.org/10.1097/MNM.0000000000000942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282663PMC
January 2019
15 Reads