5,241 results match your criteria Nuclear Medicine Communications[Journal]


Quantitative assessment of liver function using hepatobiliary scintigraphy: the effect of microcirculatory alterations after portal vein embolization.

Nucl Med Commun 2019 Apr 16. Epub 2019 Apr 16.

Departments of Surgery.

Objectives: Hepatobiliary scintigraphy using technetium-99m mebrofenin has been validated as a quantitative liver function test. Preoperative portal vein embolization (PVE) is performed in patients to increase future remnant liver function and volume. Changes in hepatic microcirculation after PVE remain largely unknown and may influence the uptake of mebrofenin. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001012DOI Listing

Tissue standardized uptake value is a closer surrogate of blood fluorine-18 fluorodeoxyglucose clearance after division by blood standardized uptake value, illustrated in brain and liver.

Nucl Med Commun 2019 May;40(5):552-554

Department of Nuclear Medicine, King's College Hospital NHS Foundation Trust, London, UK.

The numerator and denominator of the left-hand side of the Gjedde-Patlak-Rutland (GPR) equation for measurement of blood fluorine-18 fluorodeoxyglucose (F-FDG) clearance into tissue (Ki) are the standardized uptake values (SUVs) of tissue and blood, respectively. The extent to which normalized time (NT) in the GPR equation exceeds real time depends on half-time of clearance of F-FDG from blood. A literature review shows that NT is fairly constant, about 100 min at 60 min postinjection of F-FDG, in keeping with our own finding of no significant difference in maximum SUV in blood 60 min postinjection of F-FDG between 39 patients with F-FDG-avid malignancy on routine PET/CT (1. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001003DOI Listing

Value of fluorine-18-fluorodeoxyglucose PET/CT in localizing the primary lesion in adrenocorticotropic hormone-dependent Cushing syndrome.

Nucl Med Commun 2019 May;40(5):539-544

Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine.

Objective: This study aimed to present a proper understanding of the fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) value in localizing the primary lesion in adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome in a relatively large case cohort.

Patients And Methods: This retrospective study included 47 patients with ACTH-dependent Cushing syndrome, who underwent an F-FDG PET/CT examination in our hospital from November 2010 to January 2018. The serum cortisol, 24 h urine cortisol, serum ACTH, and high-dose dexamethasone suppression test were measured in all the patients. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000989DOI Listing
May 2019
1 Read

A 5-year longitudinal evaluation in patients with mild cognitive impairment by 11C-PIB PET/CT: a visual analysis.

Nucl Med Commun 2019 May;40(5):525-531

Departments of Nuclear Medicine, Molecular Imaging Research Group (IDIVAL).

Objective: The aim of this study was to evaluate the cerebral amyloid distribution in patients with mild cognitive impairment (MCI), assessed by carbon-11-Pittsburgh compound B (C-PIB) PET/CT, after 5 years of follow-up.

Patients And Methods: Ten amnestic MCI (A-MCI) and four nonamnestic (NA-MCI) patients were studied by C-PIB PET/CT and re-evaluated 5 years later by a new C-PIB PET/CT. PET/CT scans were acquired 60-90 min after the administration of 555 MBq C-PIB and analyzed visually, to obtain a score of the cerebral cortical C-PIB retention in the frontal, basal ganglia (BG), temporoparietal (TP), occipital, posterior cingulate, and cerebellum areas. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001004DOI Listing
May 2019
1 Read

Clinical features and therapeutic outcomes of patients with papillary thyroid microcarcinomas and larger tumors.

Nucl Med Commun 2019 May;40(5):477-483

Departments of Nuclear Medicine.

Objective: The aim of this study was to identify clinical features and therapeutic outcomes of patients with papillary thyroid cancer (PTC) according to tumor diameter and evaluate the correlation of neck lymph node (LN) involvement of papillary thyroid microcarcinoma (PTMC) according to patients' age.

Patients And Methods: We divided 467 patients into two groups according to tumor diameter: PTMC group (≤1 cm) and non-PTMC group (>1 cm). The clinical data were analyzed retrospectively. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000991DOI Listing
May 2019
1 Read

Micro-PET imaging of [18F]fluoroacetate combined with [18F]FDG to differentiate chronic Mycobacterium tuberculosis infection from an acute bacterial infection in a mouse model: a preliminary study.

Nucl Med Commun 2019 Mar 29. Epub 2019 Mar 29.

Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University.

Background: Mycobacterium tuberculosis (TB) infection infection is one of the deadliest infectious diseases worldwide and is responsible for 1.7 million deaths per year. The increase in multidrug-resistant TB poses formidable challenges to the global control of tuberculosis. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001017DOI Listing
March 2019
1 Read

Correlation between tumour biology status measured in triple-tracer 18F-fluorodeoxyglucose-18F-fluorothymidine- 18F-fluoromisonidazole-PET/CT study and human papillomavirus status in patients with head and neck cancer.

Nucl Med Commun 2019 Mar 28. Epub 2019 Mar 28.

Chair and Department of Electroradiology, Medical University, Poznan, Poland.

Objective: Human papillomavirus (HPV) has been usually associated with gynaecological cancers; however, recent studies have shown that this virus plays an important role in head and neck cancer. The aim of this study was to correlate PET/CT parameters in HPV-positive (HPV) and HPV-negative (HPV) patients using three tracers showing glucose metabolism, proliferation and hypoxia.

Patients And Methods: Thirty-six patients (10 females and 26 males) with newly diagnosed head and neck cancer were enroled to this retrospective study. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001016DOI Listing
March 2019
2 Reads

Comparison of the volumetric and radiomics findings of 18F-FDG PET/CT images with immunohistochemical prognostic factors in local/locally advanced breast cancer.

Nucl Med Commun 2019 Mar 28. Epub 2019 Mar 28.

Department of Nuclear Medicine, School of Medicine, Dokuz Eylul University, Izmir, Turkey.

Objective: The aim of this study was to determine the change in volumetric and radiomics parameters of fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) imaging in local/locally advanced cancer patients according to immunohistochemical findings.

Patients And Methods: A total of 72 patients who were diagnosed with local/locally advanced breast cancer and then examined by F-FDG PET/CT for staging were included in this study. Immunohistochemical prognostic factors [estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (Her-2), p53 mutation, Ki-67 proliferation index] and histological grades were determined. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001019DOI Listing

Can 18F-FDG PET/CT diagnose malignant change in benign chondroid tumors?

Nucl Med Commun 2019 Mar 27. Epub 2019 Mar 27.

Departments of Nuclear Medicine and Molecular Imaging.

Aim: The aim of this study was to determine whether fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) can diagnose malignant change in benign chondroid tumors.

Patients And Methods: This study included patients with clinicoradiological features of a chondroid tumor who were referred for a F-FDG PET/CT study to evaluate clinical suspicion of malignant change. Metabolic characteristics of the suspected lesion in the form of maximum standardized uptake value (SUVmax) was obtained and compared with histopathology. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001015DOI Listing

Visual and semiquantitative analysis of 82Rb uptake in malignant tumors on PET/CT: first systematic analysis.

Nucl Med Commun 2019 May;40(5):532-538

Department of Radiology, UNC School of Medicine, Division of Nuclear Medicine.

Objective: The objective of this study was to analyze the uptake of rubidium in malignant tumors.

Participants And Methods: Sixteen malignant lesions were included. Two radiologists compared each lesion to four references (subcutaneous fat, lung, mediastinal blood pool, and liver) at rest and stress and scored as 1-4. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001011DOI Listing

The role of 18F-FDG PET/CT in soft tissue sarcoma.

Nucl Med Commun 2019 Mar 22. Epub 2019 Mar 22.

IRCCS Rizzoli Orthopaedic Institute.

Introduction: Soft tissue sarcomas (STS) are highly fluorine-18-fluorodeoxyglucose (F-FDG)-avid tumours. PET seems to be effective for the assessment of the extent of disease. However, the use of PET to stratify STS into different risk histotypes still remains controversial. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001002DOI Listing
March 2019
3 Reads

Bone scan index as metastatic bone disease quantifier and predictor of radium-223-dichloride biochemical response.

Nucl Med Commun 2019 Mar 22. Epub 2019 Mar 22.

Department of Radiation Sciences and Technologies and Health Biosignals, Lisbon School of Health Technology, Lisbon, Portugal.

Objectives: This work aims to assess whether the biochemical response of radium-223-dichloride treatment can be predicted based on the pretherapy bone scan, and consequently if bone scan index (BSI) and maximum lesion intensity have a place as alternatives or as complements to extent of bone disease (EOBD) scoring in predicting biochemical response to treatment. Many cases of advanced prostate cancer have evidence of bone metastasis. Accurate EOBD quantification could help predict the response to radium-223-dichloride therapy. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001005DOI Listing
March 2019
1 Read

Comparison of PERCIST and RECIST criteria for evaluation of therapy response after yttrium-90 microsphere therapy in patients with hepatocellular carcinoma and those with metastatic colorectal carcinoma.

Nucl Med Commun 2019 May;40(5):461-468

Departments of Nuclear Medicine.

Objective: Yttrium-90 (Y) microsphere therapy has been increasingly used to treat hepatocellular carcinoma (HCC) and liver metastasis of colorectal cancer (mCRC). This study aims to compare two different criterias used for therapy response evaluation following Y therapy within the same group of patients.

Patients And Methods: A total of 21 patients with HCC and 19 patients with mCRC were included in this study, with 36 and 42 liver lesions, respectively. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001014DOI Listing
May 2019
1.371 Impact Factor

Measurement of 18F-FDG PET tumor heterogeneity improves early assessment of response to bevacizumab compared with the standard size and uptake metrics in a colorectal cancer model.

Nucl Med Commun 2019 Mar 18. Epub 2019 Mar 18.

Department of Radiology, Barts and London NHS Trust.

Purpose: Treatment of metastatic colorectal cancer frequently includes antiangiogenic agents such as bevacizumab. Size measurements are inadequate to assess treatment response to these agents, and newer response assessment criteria are needed. We aimed to evaluate F-FDG PET-derived texture parameters in a preclinical colorectal cancer model as alternative metrics of response to treatment with bevacizumab. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000992DOI Listing
March 2019
2 Reads

Standardization of the specific binding ratio in [123I]FP-CIT SPECT: study by striatum phantom.

Nucl Med Commun 2019 May;40(5):484-490

Department of Radiology, Municipal Tsuruga Hospital, Tsuruga, Japan.

Objective: The quantitative values of the specific binding ratio (SBR) in [I]FP-CIT have been reported to change because of differences in apparatus, collection conditions, and image reconstruction. The aim of this study was to clarify the distribution of calculated SBR values by performing [I]FP-CIT single-photon emission computed tomography in a multicenter collaborative study using a phantom. A simple correction method was also devised that enables direct comparison of the SBR value calculated at one facility with those calculated at other facilities. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001010DOI Listing

An enlarged left adrenal gland is an indirect sign of infection on 18F-FDG PET/CT.

Nucl Med Commun 2019 Mar 14. Epub 2019 Mar 14.

Nuclear Medicine and Nancyclotep Experimental Platform.

Objectives: To determine whether hypermetabolisms of the spleen and bone marrow and an enlarged adrenal gland are significant indirect signs of infection on fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT performed in patients with known or suspected infectious disease.

Patients And Methods: Potential indirect signs of infection were as follows: (i) investigated in a retrospectively selected group of patients referred to F-FDG PET/CT for a known or suspected infectious disease and among whom the presence or absence of infectious foci was ascertained in 43 and 12 cases, respectively, and (ii) further validated in groups prospectively constituted of 12 patients with severe sepsis and of 39 control patients with no sign of any infectious disease. Standardised uptake values were determined on left adrenal gland, spleen and bone marrow, whereas the size of left adrenal gland was assessed by its maximal surface on unenhanced axial computed tomography (CT) slices. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001013DOI Listing

Cost-effectiveness of second-line diagnostic investigations in patients included in the DANTE trial: a randomized controlled trial of lung cancer screening with low-dose computed tomography.

Nucl Med Commun 2019 May;40(5):508-516

Department of Thoracic Surgery, AIOU, Verona, Italy.

Aim: The aim of this study was to analyze the economic efficiency of second-line diagnostic investigations in patients with undetermined lung nodules.

Participants And Methods: A retrospective review of all surgical cases included in the DANTE trial from 2001 to 2006 for lung cancer screening was performed. Overall, 217 patients and 261 lung nodules were analyzed. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000993DOI Listing

Cis-4-[18F]fluoro-D-proline detects neurodegeneration in patients with akinetic-rigid parkinsonism.

Nucl Med Commun 2019 Apr;40(4):383-387

Institute of Neuroscience and Medicine (INM-3, -4, -5), Forschungszentrum Jülich, Jülich.

Objectives: This study aimed to investigate whether the amino acid PET tracer cis-4-[F]fluoro-D-proline [D-cis-[F]FPro] shows increased uptake in the basal ganglia of patients with neurodegenerative akinetic-rigid parkinsonism. D-Cis-[F]FPro is a sensitive PET tracer for inflammation-associated neurodegeneration in animal models. We hypothesized that D-cis-[F]FPro might also be a sensitive marker of alterations of the basal ganglia in parkinsonian syndromes. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000982DOI Listing
April 2019
3 Reads

18F-PBR06 PET/CT imaging for evaluating atherosclerotic plaques linked to macrophage infiltration.

Nucl Med Commun 2019 Apr;40(4):370-376

Department of Nuclear Medicine, Zhongshan Hospital.

Background: The present study explored the 18 kDa translocator protein radioligand [F]N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline (F-PBR06) targeting macrophages for PET imaging of atherosclerotic plaques and evaluating the vulnerability of atherosclerotic plaques toward rupture.

Materials And Methods: F-PBR06 was synthesized using a Synthra RNplus module automatically. RAW264. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000978DOI Listing
April 2019
5 Reads

Effect of forced diuresis during 18F-DCFPyL PET/CT in patients with prostate cancer: activity in ureters, kidneys and bladder and occurrence of halo artefacts around kidneys and bladder.

Nucl Med Commun 2019 Mar 5. Epub 2019 Mar 5.

Department of Nuclear Medicine, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands.

Forced diuresis may improve readability of 2-(3-(1-carboxy-5-[(6-[F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid (F-DCFPyL) PET/computed tomography (CT) by reducing focal ureteral activity. A total of 40 patients received furosemide simultaneously with F-DCFPyL (cohort 1) and 40 patients received furosemide 85 min after F-DCFPyL administration (cohort 2). The frequency of occurrence of activity depositions in ureters and halo artefacts near the kidneys and bladder was measured, as well as intensity of F-DCFPyL uptake in kidneys and bladder. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001007DOI Listing

Does the dose of iodine-131 influence the incidence of Graves' ophthalmopathy?

Nucl Med Commun 2019 May;40(5):455-460

Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Temple University Health System.

Background: Radioactive iodine-131 (RAI) is an established treatment for patients with Graves' hyperthyroidism. RAI is reported to be associated with a 20-30% incidence of development or exacerbation of Graves' ophthalmopathy (GO). This study compares the progression of GO in patients who had evidence or no evidence of GO before RAI therapy. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001008DOI Listing
May 2019
4 Reads

Gated single-photon emission computed tomography myocardial perfusion imaging is superior to computed tomography attenuation correction in discriminating myocardial infarction from attenuation artifacts in men and right coronary artery disease.

Nucl Med Commun 2019 May;40(5):491-498

School of Computing, University of Southern Mississippi, Long Beach, Mississippi, USA.

Background: In single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) studies, attenuation artifacts frequently cause false positives, which can be partially overcome by computed tomography attenuation correction (CT-AC) or gated acquisition [gated myocardial perfusion imaging (GMPI)]. The purpose of this study is to evaluate their relative diagnostic performances for coronary artery disease (CAD).

Patients And Methods: We enrolled 181 patients who underwent gated SPECT with CT-AC in this study. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001009DOI Listing
May 2019
4 Reads

Dynamics of fluorine-18-fluorodeoxyglucose uptake in the liver and its correlation with hepatic fat content and BMI.

Nucl Med Commun 2019 May;40(5):545-551

Department of Radiology, Hospital of the University of Pennsylvania.

Purpose: The aim of this study was to explore the rate of elimination of fluorine-18-fluorodeoxyglucose (F-FDG) from the liver and assess the impact of hepatic fat and obesity on F-FDG clearance in early and delayed PET scans. We hypothesized that an increase in liver fat may cause a decline in hepatic F-FDG elimination with potential consequences as measured by dual time-point F-FDG PET/CT imaging.

Patients And Methods: A total of 32 patients from the Cardiovascular Molecular Calcification Assessed by F-NaF PET/CT (CAMONA) clinical trial (17 males, 15 females; mean age: 47. Read More

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http://Insights.ovid.com/crossref?an=00006231-900000000-9843
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http://dx.doi.org/10.1097/MNM.0000000000001000DOI Listing
May 2019
20 Reads

Validation of quantitative salivary gland scintigraphy in relation to the American-European concensus criteria for Sjögren's syndrome.

Nucl Med Commun 2019 Apr;40(4):343-348

Department of Nuclear Medicine.

Purpose: The aim of this retrospective study was to evaluate the diagnostic value of semiquantitative parameters in salivary gland scintigraphy (SGS) in the diagnostic work-up of primary Sjögren's Syndrome (SS) using the American-European consensus criteria (AECC) as the gold standard.

Patients And Methods: 99mTc-pertechnetate-SGS was performed in 110 patients with suspected primary SS. Uptake ratios (URs) and excretion fractions (EFs) for all parotid and submandibular salivary glands were calculated. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000983DOI Listing
April 2019
3 Reads

Role of 18F-FDG PET/CT in infection of cardiovascular implantable electronic devices: review of the literature and initial experience.

Nucl Med Commun 2019 Feb 21. Epub 2019 Feb 21.

Department of Nuclear Medicine, Royal Liverpool University Hospital, Liverpool, UK.

Infections involving cardiovascular implantable electronic devices are becoming increasingly common, and increasingly complex to manage. Advances in technology have made implantable electronic devices smaller, and easier to implant, and patients are now also more likely to be older, with more complex comorbidities. Infections related to these devices are, however, not decreasing, and in some settings, these are rising. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000995DOI Listing
February 2019
1 Read

The negative correlation between energy consumption and communication efficiency in motor network.

Nucl Med Commun 2019 May;40(5):499-507

Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences.

Objective: Motor network plays an important role in people's daily lives. However, until now, the energy consumption mechanism of motor network remains unclear. In this study, we aimed to investigate the energy consumption of motor network. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001001DOI Listing

Radioguided lung lesion localization: introducing a fluoroscopy system in a SPECT/CT scan.

Nucl Med Commun 2019 Feb 15. Epub 2019 Feb 15.

Department of Nuclear Medicine, University of Brescia, Brescia, Italy.

Purpose: The purpose was to report our experience in the use of radiotracer localization and resection of small, indistinct, or nonpalpable pulmonary lesions. We developed an innovative technique implementing a fluoroscopy system on a single-photon emission computed tomography/computed tomography (SPECT/CT) scan that allowed to perform CT-guided injection of radiotracer directly on SPECT/CT.

Patients And Methods: Patients were selected for the radiotracer procedure in presence of difficulties in locating nodules with video-assisted thoracoscopic surgery (VATS). Read More

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http://dx.doi.org/10.1097/MNM.0000000000000999DOI Listing
February 2019

Spatial dependence of activity concentration recovery for a conjugate gradient (Siemens xSPECT) algorithm using manufacturer-defined reconstruction presets.

Authors:
Ian S Armstrong

Nucl Med Commun 2019 Mar;40(3):287-293

Nuclear Medicine Centre, Manchester University NHS Foundation Trust, Manchester, UK.

Siemens absolute quantitative reconstruction, xSPECT, is available with manufacturer-defined reconstruction presets to assist with optimization. This phantom study evaluates the impact of these presets on the spatial dependence of activity concentration recovery (ACR). Single-photon emission computed tomography/computed tomography scans of a 5 : 1 and 10 : 1 (sphere : background) contrast NEMA phantom were performed on a Siemens Intevo 6. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000960DOI Listing
March 2019
1.371 Impact Factor

Synthesis and preclinical evaluation of the 177Lu-DOTA-PSMA(inhibitor)-Lys3-bombesin heterodimer designed as a radiotheranostic probe for prostate cancer.

Nucl Med Commun 2019 Mar;40(3):278-286

Facultad de Medicina.

Backround: Human tumors show intrinsic heterogeneity and changes in phenotype during disease progression, which implies different expression levels of cell surface receptors. The research on new heterodimeric lutetium-177 (Lu)-radiopharmaceuticals interacting with two different targets on tumor cells is a strategy for improvement of radiotheranostic performance. This study aimed to synthesize and characterize the Lu-DOTA-PSMA(inhibitor)-Lys-bombesin (Lu-DOTA-iPSMA-Lys-BN) heterodimer and to evaluate its potential to target prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPr) overexpressed in prostate cancer. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000966DOI Listing
March 2019
1 Read

Usefulness of respiratory-gated 18F-FDG PET/CT scan protocol in patients having positive myocardial 18F-FDG uptake.

Nucl Med Commun 2019 Mar;40(3):235-241

Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University Hospital.

Objective: The aim of this study were to estimate the influence of respiratory movement on the fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) imaging of patients having positive myocardial F-FDG uptake and to demonstrate an adequate respiratory-gated F-FDG PET/CT scan protocol.

Materials And Methods: An anthropomorphic chest phantom containing a cardiac ventricle phantom was filled with an fluorine-18 solution and scanned in both a nonmoving state and a moving state with respiratory gating. In the nonmoving state, PET images were acquired in static mode (static PET), whereas in the moving state, PET images were acquired in a nongated mode (nongated PET), and in a gated mode (gated PET). Read More

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http://dx.doi.org/10.1097/MNM.0000000000000947DOI Listing

Quantitative analysis of technetium-99m-sestamibi uptake and washout in parathyroid scintigraphy supports dual mechanisms of lesion conspicuity.

Nucl Med Commun 2019 May;40(5):469-476

Department of Medicine, Division of Nuclear Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Purpose: Proposed mechanisms of parathyroid localization in 'dual-phase' technetium-99m-sestamibi imaging include increased presence of mitochondria leading to greater uptake and slower washout compared with thyroid tissues owing to reduced expression of P-glycoprotein. Using new techniques of quantitative single-photon emission computed tomography (SPECT)/computed tomography (CT), we have measured MIBI uptake and washout to better understand factors related to conspicuity.

Patients And Methods: We retrospectively reviewed 125 consecutive patients. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000996DOI Listing
May 2019
1 Read

Time trend analysis of pulmonary embolism diagnosis with single-photon emission computed tomography ventilation/perfusion imaging.

Nucl Med Commun 2019 Feb 7. Epub 2019 Feb 7.

Department of Nuclear Medecine.

Objective: Following the implementation of single-photon emission computed tomography ventilation/perfusion (SPECT V/Q) in our department, we previously carried out an observational study over the period 2011-2013 that showed the safety of SPECT V/Q to rule out pulmonary embolism (PE). However, PE prevalence (28%) was high compared with some studies. Our hypothesis was that the use of SPECT V/Q may be responsible for an overdiagnosis of PE, especially at the implementation phase of the test. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000990DOI Listing
February 2019
7 Reads

Evaluation of cyclic direct radionuclide cystography findings with DMSA scintigraphy results in children with a prior diagnosis of vesicoureteral reflux.

Nucl Med Commun 2019 Feb 7. Epub 2019 Feb 7.

Department of Nuclear Medicine, Adana Teaching and Medical Research Center, Faculty of Medicine, Baskent University, Ankara, Turkey.

Objectives: Direct radionuclide cystography (DRC) with cyclic imaging is a sensitive method used for the detection of vesicoureteral reflux (VUR). Radionuclide cystography is generally recommended for follow-up evaluation of VUR. The aim of this study was to evaluate cyclic DRC with DMSA scan results during the follow-up period in children with a prior diagnosis of VUR. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000994DOI Listing
February 2019
2 Reads

Radiochemical purity of technetium-99m-nanocolloid rhenium sulphide is not influenced by heating.

Nucl Med Commun 2019 Jan 31. Epub 2019 Jan 31.

Radiopharmacy Unit, Departement of Pharmacy, Groupement Hospitalier Est, Hospices Civils de Lyon, 59 boulevard Pinel, 69677 Bron Cedex.

Despite a mistake during the preparation of technetium-99m (Tc)-nanocolloid rhenium sulphide (Nanocis) because of lack of heating, the apparent radiochemical purity (RCP) of this product was correct. The objectives of this study were to evaluate the impact of absence of heating on the RCP of Tc-nanocolloid rhenium sulphide and the effect of heating on particle size. Five Tc-Nanocis were prepared according to the manufacturer's instructions and five others were realized without any heating step. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000988DOI Listing
January 2019
1 Read

Diagnostic value of adrenal iodine-131 6-beta-iodomethyl-19-norcholesterol scintigraphy for primary aldosteronism: a retrospective study at a medical center in North Taiwan.

Nucl Med Commun 2019 Jan 28. Epub 2019 Jan 28.

Department of Internal Medicine, Division of Endocrinology and Metabolism, College of Medicine.

Background: Primary aldosteronism (PA) is a common cause of secondary hypertension. Among the many leading causes of PA, the two most frequent are, bilateral adrenal hyperplasia (BAH) and aldosterone-producing adenomas (APA). Since a solitary APA may be cured surgically, but BAH needs lifelong pharmacologic therapy, confirmation is mandatory before surgery. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000987DOI Listing
January 2019
5 Reads

Comparison of (18F)FDG PET/CT and (68Ga)DOTATATE PET/CT imaging methods in terms of detection of histological subtype and related SUVmax values in patients with pulmonary carcinoid tumors.

Nucl Med Commun 2019 May;40(5):517-524

Department of Nuclear Medicine, Diyarbakir Gazi Yasargil Training and Research Hospital.

Objective: This study was designed to compare the 18-Fluorodeoxyglucose positron emission tomography/computed tomography [(F)FDG PET/CT] and 1,4,7,10-tetraazacyclododecane-NI,NII,NIII,NIIII-tetraacetic acid (D)-Phe1-thy3-octreotate [(Ga)DOTATATE PET/CT) findings in patients with pulmonary carcinoid (PC) tumors.

Materials And Methods: A total of 20 patients [mean (SD) age: 52.2 (12. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000985DOI Listing
May 2019
4 Reads

Correlation of fluorine 18-labeled sodium fluoride uptake and arterial calcification on whole-body PET/CT in cancer patients.

Nucl Med Commun 2019 Jan 25. Epub 2019 Jan 25.

Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Fluorine-18-labeled sodium fluoride (F-NaF) uptake measured with PET in the vessel walls can indicate active microcalcification, a potential biomarker of higher-risk plaques, which are not indicated by macrocalcification measured with computed tomography (CT). The aim of this study was to determine the extent to which F-NaF uptake is correlated with calcification at arterial plaques in cancer patients undergoing whole-body PET/CT imaging.

Patients And Methods: Image data from 179 patients who underwent F-NaF PET/CT were evaluated retrospectively. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000986DOI Listing
January 2019
1 Read

Stress test of liver function using technetium-99m-mebrofenin hepatobiliary scintigraphy.

Nucl Med Commun 2019 Apr;40(4):388-392

Radiology and Nuclear Medicine.

Technetium-99m (Tc) mebrofenin hepatobiliary scintigraphy (HBS) enables a quantitative assessment of liver function. This is normally performed in a fasting state and might therefore reflect the resting liver function. We evaluated the change in liver function using HBS after stimulation with an oral metabolic challenge. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000979DOI Listing

Impact of hibernating and viable myocardium on improvement in perfusion and left ventricular ejection fraction after coronary artery bypass graft.

Nucl Med Commun 2019 Apr;40(4):325-332

Nuclear Medicine.

Objectives: The association between the extent and degree of perfusion-metabolism mismatch and improvement in perfusion and left ventricular ejection fraction (LVEF) after revascularization was assessed. The secondary aim was to identify the best precoronary artery bypass graft surgery (pre-CABG) PET parameter, if any, to predict the improvement in the perfusion and LVEF after CABG.

Methods And Results: Overal, 31 patients (mean age: 58+8. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000976DOI Listing

An investigation into the accuracy of using serum creatinine estimated glomerular filtration rate to predict measured glomerular filtration rate.

Nucl Med Commun 2019 Apr;40(4):349-352

Departments of Radiation Physics and Protection.

Objectives: The aim of the study was to identify a threshold value of the estimated glomerular filtration rate (eGFR) that would predict a measured glomerular filtration rate (mGFR) of ≤25 ml/min/1.73 m. This is to guide use of the new British Nuclear Medicine Society guidelines, which specifies a 24 h sample for patients with a GFR of ≤25 ml/min/1. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000980DOI Listing

18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications.

Nucl Med Commun 2019 Apr;40(4):377-382

Nuclear Medicine Department, Lady Davis Institute, Jewish General Hospital.

Background: To compare the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) and conventional tests for cancer screening in autoimmune inflammatory myopathy (AIM) patients.

Patients And Methods: We carried out a retrospective cohort study of AIM patients from one academic center in Montreal, Canada, classified using myositis-specific antibodies, who underwent F-FDG PET/CT between April 2005 and February 2018 and were followed up on average 3.5±2. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000981DOI Listing
April 2019
7 Reads

Amersham radiopharmaceuticals: a global scientific and industrial legacy for nuclear medicine.

Authors:
Alan C Perkins

Nucl Med Commun 2019 Mar;40(3):191-193

Department of Radiological Sciences, School of Medicine, Medical Physics and Clinical Engineering, Nottingham University Hospitals, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1097/MNM.0000000000000984DOI Listing
March 2019
1 Read

Propagation of measurement errors in glomerular filtration rate determination: a comparison of slope-intercept, single-sample and slope-only methods.

Nucl Med Commun 2019 Apr;40(4):333-342

Department of Medical Imaging and Clinical Oncology, Nuclear Medicine Division, Stellenbosch University.

Background: Measurement errors occurring during glomerular filtration rate (GFR) studies propagate to an error in the calculated GFR. Previous work has modelled measurement errors for slope-intercept (SI-GFR), single-sample (SS-GFR) and slope-only (SO-GFR) methods. In this study, we have extended these models. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000977DOI Listing
April 2019
5 Reads
1.371 Impact Factor

Prognostic value of 18F-FDG PET/CT functional parameters in patients with head and neck cancer: a meta-analysis.

Nucl Med Commun 2019 Apr;40(4):361-369

Chengdu First People's Hospital, Hi-Tech Zone, Chengdu, People's Republic of China.

Purpose: We performed this meta-analysis to evaluate the prognostic value of maximum of standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) in patients with head and neck cancer.

Methods: Articles including prognostic value of PET/CT were searched in PubMed and subsequently analyzed. The primary outcome of interest was event-free survival, and the secondary outcome of interest was overall survival. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000974DOI Listing
April 2019
1 Read
1.371 Impact Factor

Significance of the preoperative regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the future remnant liver: a sequential study of regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the whole liver.

Nucl Med Commun 2019 Feb;40(2):145-152

Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki.

Background: The relationship between posthepatectomy complications and liver functional parameters was preliminary reported in a pilot study. The present study sequentially evaluated the clinical significance of maximal removal rate of technetium-99m-galactosyl human serum albumin (GSARmax) in the future remnant liver (rGSARmax) in patients to predict posthepatectomy complications.

Methods: Between 2010 and August 2017, GSARmax, rGSARmax, their difference (Dif), and the rGSARmax to GSARmax ratio were examined in 247 additional patients who underwent hepatectomy for liver and biliary diseases. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000950DOI Listing
February 2019
1 Read

2015 UK software audit of hepatobiliary scintigraphy.

Nucl Med Commun 2019 Feb;40(2):136-144

St Luke's Hospital, Dublin, Ireland.

Introduction: This audit investigated hepatobiliary function imaging in UK hospitals, reviewing protocol differences in acquisition and processing parameters and the effect on calculated gallbladder ejection fraction (GBEF).

Participants And Methods: Two dynamic data sets were available: one continuous dynamic data set, and the other with a 5-min break to administer the fatty stimulus. Participants used a set of 12 anonymized patient data sets most similar to their standard protocol calculating GBEF using their routine method. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000948DOI Listing
February 2019
2 Reads

Challenges using PET-CT for international multicentre coordinated research projects in developing countries.

Nucl Med Commun 2019 Feb;40(2):93-95

Nuclear Medicine Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.

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http://dx.doi.org/10.1097/MNM.0000000000000958DOI Listing
February 2019

18F-FDG PET/CT and nestin expression as prognostic tools in pulmonary neuroendocrine tumours.

Nucl Med Commun 2019 Apr;40(4):353-360

Departments of Endocrinology, Metabolism and Internal Medicine.

Objectives: The aim of this study was to investigate the fluorine-18-fluorodeoxyglucose (F-FDG) uptake on integrated PET [PET/computed tomography (CT)] images and its correlation with nestin expression in a series of neuroendocrine lung tumours. As the incidence of neuroendocrine lung tumours is rising, tools predicting diagnosis, outcome and assisting in the selection of treatment regimens are needed.

Patients And Methods: We reviewed records of patients diagnosed with large cell neuroendocrine lung carcinoma, atypical carcinoid and typical carcinoid who were operated upon in our institution. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000972DOI Listing

Relationship between regional hepatic glucose metabolism and regional distribution of hepatic fat.

Nucl Med Commun 2019 Mar;40(3):212-218

Brighton and Sussex University Hospitals NHS Trust.

Aim: Hepatic steatosis is associated with insulin resistance and hyperinsulinaemia. Insulin stimulates hepatic glucokinase, even in insulin resistance, so hepatic glucose uptake is increased in hepatic steatosis. The study hypothesis was that hepatic glucose uptake is also influenced locally by fat, the hepatic distribution of which is heterogeneous. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000968DOI Listing
March 2019
13 Reads

The relationship between thyroid eye disease and radioiodine treatment.

Nucl Med Commun 2019 Mar;40(3):194-198

Department of Nuclear Medicine, National Cancer Center, Calmette University Hospital, Phnom Penh, Cambodia.

Thyroid eye disease is the most frequent extrathyroidal manifestation of Graves' disease and it can have a major negative impact on the quality of life of affected patients. Therefore, it is crucial to have a correct and early diagnosis. Thyroid eye disease management should be multidisciplinary. Read More

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http://Insights.ovid.com/crossref?an=00006231-900000000-9845
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http://dx.doi.org/10.1097/MNM.0000000000000965DOI Listing
March 2019
7 Reads