5,368 results match your criteria Nosocomial Pneumonia


Description of Clinical Characteristics of VAP Patients in MIMIC Database.

Front Pharmacol 2019 4;10:62. Epub 2019 Feb 4.

Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection of intensive-care units (ICUs). Accurate, timely diagnosis enables early VAP patients to receive appropriate therapies and reduce the occurrence of complication. However, so far clinical datas regarding the epidemiology and mortality of VAP are still limited. Read More

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http://dx.doi.org/10.3389/fphar.2019.00062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369200PMC
February 2019

Burden of healthcare-associated infections at six tertiary-care hospitals in Saudi Arabia: A point prevalence survey.

Infect Control Hosp Epidemiol 2019 Feb 19:1-3. Epub 2019 Feb 19.

Infection Prevention and Control Department, King Abdulaziz Medical City (KAMC),Ministry of National Guard Health Affairs (MNGHA),Riyadh,Saudi Arabia.

ABSTRACTA point prevalence survey was conducted on May 11, 2017, among inpatients at 6 hospitals in Saudi Arabia. The overall point prevalence was 6.8% (114 of 1,666). Read More

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http://dx.doi.org/10.1017/ice.2018.338DOI Listing
February 2019

The clinical impacts and risk factors for non-central line-associated bloodstream infection in 5046 intensive care unit patients: an observational study based on electronic medical records.

Crit Care 2019 Feb 18;23(1):52. Epub 2019 Feb 18.

Department of Infection Control, West China Hospital of Sichuan University, Chengdu, China.

Background: Most of the previous studies focused on central line-associated bloodstream infection (CLABSI), while non-central line-associated bloodstream infection (N-CLABSI) was poorly studied. This study was performed to investigate the clinical impacts and risk factors for N-CLABSI in intensive care unit (ICU) patients.

Methods: An observational study was conducted in an adult general ICU. Read More

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http://dx.doi.org/10.1186/s13054-019-2353-5DOI Listing
February 2019

Nosocomial Pneumonia in the ICU: Still More Questions Than Answers.

Crit Care Med 2019 Mar;47(3):472-473

Critical Care Institute, Keck Hospital of USC; and Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1097/CCM.0000000000003600DOI Listing

Increased Healthcare-Associated Infections in a Surgical Intensive Care Unit Related to Boarding Non-Surgical Patients.

Surg Infect (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

3 Department of Surgery, Division of Acute Care Surgery Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Background: Hospital over-capacity often forces boarding patients outside of their designated intensive care unit (ICU). Anecdotal evidence suggested medical intensive care unit (MICU) patients boarding in the surgical intensive care unit (SICU) were responsible for increases in healthcare-associated infection (HAI) rates. We studied the effect of ICU boarding on rates of SICU HAIs. Read More

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https://www.liebertpub.com/doi/10.1089/sur.2018.240
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http://dx.doi.org/10.1089/sur.2018.240DOI Listing
February 2019
1 Read

A Case of Fulminant Bacillus cereus Lung Necrosis in a Preterm Neonate.

Pediatr Dev Pathol 2019 Feb 13:1093526619825895. Epub 2019 Feb 13.

5 Department of Pathology and Laboratory Medicine, The Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Bacillus cereus is a ubiquitous Gram-positive rod seldom considered pathogenic in clinical isolates. However, it possesses multiple virulence factors explaining why it has been linked to fulminant and pyogenic infections in vulnerable hosts. Its recovery from sterile samples in immunocompromised patients cannot be disregarded. Read More

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http://dx.doi.org/10.1177/1093526619825895DOI Listing
February 2019

In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila.

J Antibiot (Tokyo) 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey.

Legionella pneumophila is a waterborne intracellular pathogenic bacterium, the most frequent cause of human legionellosis and a relatively common cause of community-acquired and nosocomial pneumonia. Some legionellosis outbreaks are related to the presence of biofilms, which provide a reservoir for L. pneumophila strains. Read More

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http://dx.doi.org/10.1038/s41429-019-0148-1DOI Listing
February 2019
1 Read

The prevalence of healthcare-associated infection in medical intensive care units in Tunisia. Results of the multi-centre nosorea1 study.

Tunis Med 2018 Oct-Nov;96(10-11):731-736

Objectives: To determine the prevalence of Healthcare-Associated Infection (HAI) in medical Intensive Care Unit (ICU), risk factors for these infections and identify the predominant infecting organisms.

Methods: A 1-day point-prevalence study within all medical ICUs in Tunisia, all patients occupying an ICU bed over a 48-hour period were included. Rates of HAI, resistance patterns of microbiological isolates and potential risk factors for HAI were recorded. Read More

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February 2019

Risk of community-acquired pneumonia in older adults with sarcopenia of a hospital from Callao, Peru 2010-2015.

Arch Gerontol Geriatr 2019 Jan 29;82:100-105. Epub 2019 Jan 29.

Universidad de San Martin de Porres, Facultad de Medicina Humana, Centro de investigación del evejecimiento (CIEN), Lima, Peru; Universidad Científica del Sur, Lima, Peru.

Introduction: Sarcopenia is a geriatric syndrome characterized by loss of muscle mass and strength. The prevalence in people between 60-70 years is about 5-13% and in adults over 80 years, between 11-50% in the USA. Sarcopenia increases the risk of mortality and nosocomial infections. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674943193000
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http://dx.doi.org/10.1016/j.archger.2019.01.008DOI Listing
January 2019
8 Reads

Health care-associated infection surveillance system in Iran: Reporting and accuracy.

Am J Infect Control 2019 Feb 6. Epub 2019 Feb 6.

Department of Health in Emergency and Disaster, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Valid data are a crucial aspect of infection prevention and control programs. The aim of this study was to examine the accuracy of routine reporting in the Iranian Nosocomial Infection Surveillance System in intensive care units.

Methods: A blinded retrospective review of general intensive care unit medical records was performed with a standard case-finding form. Read More

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http://dx.doi.org/10.1016/j.ajic.2018.12.028DOI Listing
February 2019

Pneumonia in hospitalized neurologic patients: trends in pathogen distribution and antibiotic susceptibility.

Antimicrob Resist Infect Control 2019 1;8:25. Epub 2019 Feb 1.

1Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744 South Korea.

Background: Bed-ridden state, dysphagia, altered mental state, or respiratory muscle weakness are common in neurologic patients and increase the risk of pneumonia. The major causes of pneumonia in neurologic patients may differ from those in the general population, resulting in a different pathogen distribution. We investigated the trends of pathogen distribution in culture-positive pneumonia in hospitalized neurologic patients and the related antibiotic resistance in those with hospital-acquired pneumonia (HAP). Read More

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http://dx.doi.org/10.1186/s13756-019-0475-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359823PMC
February 2019
1 Read

Study the antibacterial and antibiofilm activity of Carum copticum against antibiotic-resistant bacteria in planktonic and biofilm forms.

Microb Pathog 2019 Feb 4;129:99-105. Epub 2019 Feb 4.

Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.

Objectives: Microbial biofilms has attracted interest in the recent years because they has become the most important cause of nosocomial infections. This study was aimed to examine the antibacterial activities of Carum copticum extracts on the development of microbial biofilms and planktonic form of six pathogenic bacteria.

Methods: Antimicrobial activity of the crude extracts against the planktonic form of six pathogenic bacteria: Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii and Klebsiella pneumonia was evaluated by using the disc diffusion method. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.002DOI Listing
February 2019
2 Reads

Evaluation of Lactobacilli for Antagonistic Activity Against the Growth, Adhesion and Invasion of and .

Indian J Microbiol 2019 Mar 27;59(1):81-89. Epub 2018 Jul 27.

2Department of Food and Nutrition, Providence University, Taichung City, 43301 Taiwan, ROC.

Urinary tract infections are the most common infectious diseases in babies and the elderly and are often acquired as nosocomial infections. The purpose of the present study was to identify strains of lactic acid bacteria (LAB) which could be used as alternatives to antibiotics for the treatment of urinary tract infections because of their ability to inhibit urinary tract pathogens ( BCRC 10694 and BCRC 17040). We screened 370 LAB strains using spent culture supernatants by inhibition zone assay to assess their antimicrobial effects. Read More

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http://dx.doi.org/10.1007/s12088-018-0753-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328402PMC
March 2019
1 Read

Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.

Drugs 2019 Feb 2. Epub 2019 Feb 2.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by Shionogi & Co., Ltd., Japan. Read More

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http://dx.doi.org/10.1007/s40265-019-1055-2DOI Listing
February 2019
2 Reads

Investigation of multidrug-resistant ST2 Acinetobacter baumannii isolated from Saint George hospital in Lebanon.

BMC Microbiol 2019 Feb 2;19(1):29. Epub 2019 Feb 2.

Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385, Marseille, Cedex 05, France.

Background: Acinetobacter baumannii is an opportunistic pathogen causing various nosocomial infections. The spread of multidrug-resistant A. baumannii is a major public health problem. Read More

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http://dx.doi.org/10.1186/s12866-019-1401-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359860PMC
February 2019
1 Read

The Role of the CopA Copper Efflux System in Virulence.

Int J Mol Sci 2019 Jan 29;20(3). Epub 2019 Jan 29.

Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, South Australia, Australia.

has emerged as one of the leading causative agents of nosocomial infections. Due to its high level of intrinsic and adapted antibiotic resistance, treatment failure rates are high, which allows this opportunistic pathogen to thrive during infection in immune-compromised patients. can cause infections within a broad range of host niches, with pneumonia and bacteraemia being associated with the greatest levels of morbidity and mortality. Read More

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http://dx.doi.org/10.3390/ijms20030575DOI Listing
January 2019
1 Read

Characterization of post-surgical critical patients with infections associated with healthcare after prolonged perfusion of remifentanil.

Rev Assoc Med Bras (1992) 2018 Aug;64(8):736-742

. Departamento de Farmacología e Instituto de Neurociencias. Facultad de Medicina, Universidad de Granada, Granada, Spain.

Introduction: Healthcare associated infections (HAI) are the most frequent complication of hospitalized patients. The aim of this study was to describe the clinical and epidemiological characteristics of critically ill post-surgical patients with a diagnosis of healthcare associated infections, after a pattern of sedoanalgesia of at least 4 days.

Methods: All patients over 18 years of age with a unit admission of more than 4 days were consecutively selected. Read More

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http://dx.doi.org/10.1590/1806-9282.64.08.736DOI Listing
August 2018
2 Reads

Burden of Respiratory Syncytial Virus Disease and Mortality Risk Factors in Argentina: 18 Years Active Surveillance in a Children´s Hospital.

Pediatr Infect Dis J 2019 Jan 10. Epub 2019 Jan 10.

Virology, Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.

Background: Respiratory Syncytial Virus (RSV) is the leading cause of acute lower respiratory infection (ALRI) in children. We aimed to describe the clinical-epidemiological pattern and risk factors for mortality associated with RSV infection.

Methods: A prospective, cross-sectional study of ALRI in children admitted to the Children's Hospital among 2000-2017. Read More

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http://Insights.ovid.com/crossref?an=00006454-900000000-9646
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http://dx.doi.org/10.1097/INF.0000000000002271DOI Listing
January 2019
7 Reads

Dose Selection and Validation for Ceftazidime-Avibactam in Adults with Complicated Intra-Abdominal Infections, Complicated Urinary Tract Infections and Nosocomial Pneumonia.

Antimicrob Agents Chemother 2019 Jan 22. Epub 2019 Jan 22.

AstraZeneca, Waltham, MA, USA.

Avibactam is a non-β-lactam β-lactamase inhibitor that has been approved in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections and nosocomial pneumonia, including ventilator-associated pneumonia. In Europe, ceftazidime-avibactam is also approved for the treatment of Gram-negative infections with limited treatment options. Selection and validation of the ceftazidime-avibactam dosage regimen was guided by an iterative process of population pharmacokinetic (PK) modelling, whereby population PK models for ceftazidime and avibactam were developed using PK data from clinical trials and updated periodically. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.02187-18
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http://dx.doi.org/10.1128/AAC.02187-18DOI Listing
January 2019
3 Reads

Comparison of OmpA Gene-Targeted Real-Time PCR with the Conventional Culture Method for Detection of Acinetobacter baumanii in Pneumonic BALB/c Mice

Iran Biomed J 2019 03;23(2):159-64

Dept. of Cell Biology, Science and Research branch, Islamic Azad University, Tehran, Iran.

Background: Acinetobacter baumannii is an important pathogen in health care and is responsible for severe nosocomial and community-acquired pneumonia. To design novel therapeutic agents, a mouse model for A. baumannii pneumonia is essential. Read More

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March 2019
4 Reads

Tug of war between Acinetobacter baumannii and host immune responses.

Pathog Dis 2018 Dec;76(9)

Department of Immunology and infectious Diseases, John Curtin School of Medical Research, Australian National University, 131 Garran Road, Acton, ACT 2601, Australia.

Acinetobacter baumannii is an emerging nosocomial, opportunistic pathogen with growing clinical significance. Acinetobacter baumannii has an exceptional ability to rapidly develop drug resistance and to adhere to abiotic surfaces, including medical equipment, significantly promoting bacterial spread and also limiting our ability to control A. baumannii infections. Read More

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https://academic.oup.com/femspd/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/femspd/ftz004DOI Listing
December 2018
3 Reads

Analysis of acute respiratory infections due to influenza virus A, B and RSV during an influenza epidemic 2018.

Infection 2019 Jan 16. Epub 2019 Jan 16.

Kliniken für Pneumologie und Infektiologie, EVK Herne und Augusta-Kranken-Anstalt Bochum, Thoraxzentrum Ruhrgebiet, Bergstrasse 26, 44791, Bochum, Germany.

Purpose: We studied the incidence, morbidity and mortality of all patients presenting in our teaching hospital with proven influenza virus and/or respiratory syncytial virus (RSV) infection during the influenza epidemic season 2018 which was characterized by a predominant incidence of influenza virus B type B of the Yamagata line.

Methods: In the fall of 2017, specific precaution measures in addition to standard measures were implemented, including standardized testing for influenza virus A,B and RSV by multiplex PCR of pharyngeal swabsData from all consecutive patients were analyzed retrospectively.

Results: Overall 651 patients were examined for the presence of influenza virus and RSV; 214 patients had influenza virus A (n = 36), B (n = 152), and/or RSV (n = 30), including four patients with dual infection. Read More

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http://link.springer.com/10.1007/s15010-018-1262-x
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http://dx.doi.org/10.1007/s15010-018-1262-xDOI Listing
January 2019
10 Reads

[Treatment strategies for congenital heart disease in infants with severe pneumonia].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1241-1245

Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To observe the results of different treatment of congenital heart disease (CHD) complicated with severe pneumonia in infants.
 Methods: A total of 27 infants with CHD and severe pneumonia were admitted to the Department of Pediatrics, Xiangya Hospital from January 2014 to December 2014, of whom 18 were male and 9 were female. The average age was 2. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.11.012DOI Listing
November 2018
1 Read

The impact of glycemic variability on length of stay and mortality in diabetic patients admitted with community-acquired pneumonia or chronic obstructive pulmonary disease.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):149-153. Epub 2018 Aug 28.

Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.

Aim: To investigate the influence of glycemic variability (GV) on length of stay and in-hospital mortality in non-critical diabetic patients.

Methods: A observation retrospective study was performed. Diabetic patients admitted between January and June 2016 with the diagnosis of community-acquire pneumonia (CAP) and/or acute exacerbation of chronic obstructive pulmonary disease (COPD) were enrolled and glycemic control (persistent hyperglycemia, hypoglycemia, mean glucose level (MGL) and respective standard deviation (SD) and coefficient of variation (CV)) were evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18714021183034
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http://dx.doi.org/10.1016/j.dsx.2018.08.028DOI Listing
August 2018
4 Reads

Awareness among intensive care nurses regarding oral care in critically ill patients.

J Indian Soc Periodontol 2018 Nov-Dec;22(6):541-545

Department of Oral Pathology and Microbiology, JSS Dental College and Hospital, Jagadguru Shri Shivarathreeshwara University, Mysuru, Karnataka, India.

Background: Oral health and general health are interdependent which influence each other through biological, psychological, emotional, and developmental factors. As patients in Intensive Care Unit (ICU) are completely dependent on the caregivers, the knowledge, attitude, and practices of the nurses influence the recovery of patients to a greater extent.

Objectives: Unfortunately, oral health problems are usually overshadowed by other serious needs in critically ill patients. Read More

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http://www.jisponline.com/text.asp?2018/22/6/541/244563
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http://dx.doi.org/10.4103/jisp.jisp_30_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305093PMC
January 2019
8 Reads

[Clinical characteristics of influenza acute respiratory distress syndrome in 2017 to 2018].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Jan;42(1):9-14

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University; Beijing Institute of Respiratory Medicine; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders;Beijing Engineering Research Center for Diagnosis and Treatment of Respiratory and Critical Care Medicine (Beijing Chaoyang Hospital), Beijing 100020, China.

To describe the clinical characteristics of acute respiratory distress syndrome (ARDS) caused by severe influenza virus in our hospital. From November 2017 to February 2018, 48 patients were diagnosed with ARDS caused by influenza virus pneumonia. There characteristics, treatment, and outcomes were summarized and analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.01.005DOI Listing
January 2019
4 Reads

[Clinical characteristics and risk factors of very low birth weight and extremely low birth weight infants with bronchopulmonary dysplasia: multicenter retrospective analysis].

Authors:

Zhonghua Er Ke Za Zhi 2019 Jan;57(1):33-39

To analyze clinical characteristics and risk factors of very low birth weight and extremely low birth weight infants with bronchopulmonary dysplasia (BPD). A retrospective epidemiological study was performed in 768 neonates (376 males) with birth weights<1 500 g and gestational age ≤ 34 weeks who survived ≥28 days. Clinical data were obtained from the multi-center clinical database of neonatal intensive care units (NICU) in 19 hospitals of Jiangsu Province between January 1, 2017 and December 31, 2017. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.01.009DOI Listing
January 2019
2 Reads

Nosocomial outbreak of extended-spectrum β-lactamase-producing Enterobacter cloacae among cardiothoracic surgical patients: causes and consequences.

J Hosp Infect 2019 Jan 7. Epub 2019 Jan 7.

Infection Control Unit, CHU UCL Namur, Yvoir, Belgium; National Reference Centre for Monitoring Antimicrobial Resistance in Gram-Negative Bacteria, CHU UCL Namur, Yvoir, Belgium.

Background: Enterobacteriaceae are recognized as leading pathogens of healthcare-associated infections.

Aim: To report the investigation of a nosocomial outbreak of extended-spectrum β-lactamase-producing Enterobacter cloacae affecting cardiothoracic surgery patients in a Belgian academic hospital.

Methods: Cases were defined based on epidemiological and microbiological investigations, including molecular typing using repetitive element-based polymerase chain reaction and multi-locus sequence typing. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.01.001DOI Listing
January 2019
1 Read

Clinical features of coinfection and need for its testing in influenza pneumonia patients.

J Thorac Dis 2018 Nov;10(11):6118-6127

Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Background: To investigate the clinical features of coinfection due to (), a common copathogen in influenza, in influenza pneumonia patients.

Methods: We reviewed 4,465 patients with influenza who visited a tertiary care hospital emergency department in Seoul (Korea) from 2010 through 2016, and underwent immunoglobulin M (IgM) serology or polymerase chain reaction (PCR) for . Influenza pneumonia was defined as laboratory-confirmed influenza plus radiographic pneumonia. Read More

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http://jtd.amegroups.com/article/view/24984/19090
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http://dx.doi.org/10.21037/jtd.2018.10.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297417PMC
November 2018
5 Reads

Outcomes Associated With De-escalating Therapy for Methicillin-Resistant Staphylococcus aureus in Culture-Negative Nosocomial Pneumonia.

Chest 2019 Jan 25;155(1):53-59. Epub 2018 Oct 25.

Barnes-Jewish Hospital, Saint Louis, MO; Saint Louis College of Pharmacy, Saint Louis, MO. Electronic address:

Background: In culture-positive nosocomial pneumonia, de-escalation (DE) from broad-spectrum empirical antimicrobials to narrower-spectrum agents has shown to decrease broad-spectrum antibiotic use without compromising patient outcomes. However, uncertainty exists regarding the safety of anti-methicillin-resistant Staphylococcus aureus (MRSA) agent DE in culture-negative nosocomial pneumonia. This study aimed to determine if anti-MRSA agent DE in culture-negative nosocomial pneumonia affects 28-day and hospital mortality, ICU and hospital length of stay (LOS), treatment failure, and safety. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183259
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http://dx.doi.org/10.1016/j.chest.2018.10.014DOI Listing
January 2019
3 Reads

Neonatal bronchoscopy: Role in respiratory disease of the newborn-A 7 year experience.

Pediatr Pulmonol 2019 Jan 8. Epub 2019 Jan 8.

Discipline of Medical Biochemistry and Chemical Pathology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences University of KwaZulu-Natal, Durban, South Africa.

Background: Bronchoalveolar lavage (BAL) is a standardized method to obtain specimen samples from the airway lumen of the respiratory system. BAL is used to diagnose lung infection and infection markers in neonates.

Objectives: The aim was to evaluate the utility of flexible fiberoptic bronchoscopy in term and preterm neonates and to evaluate the use of BAL obtained by bronchoscopy in neonatal lung disease. Read More

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http://dx.doi.org/10.1002/ppul.24243DOI Listing
January 2019
2 Reads

Relationship Between the Quorum Network (Sensing/Quenching) and Clinical Features of Pneumonia and Bacteraemia Caused by .

Front Microbiol 2018 17;9:3105. Epub 2018 Dec 17.

Microbiology Department-Biomedical Research Institute A Coruña (INIBIC), Hospital A Coruña (CHUAC), University of A Coruña (UDC), A Coruña, Spain.

(Ab) is one of the most important pathogens associated with nosocomial infections, especially pneumonia. Interest in the Quorum network, i.e. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.03105
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http://dx.doi.org/10.3389/fmicb.2018.03105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304438PMC
December 2018
4 Reads

Recommendations and guidelines for the treatment of pneumonia in Taiwan.

J Microbiol Immunol Infect 2019 Feb 6;52(1):172-199. Epub 2018 Dec 6.

Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung, Taiwan.

Pneumonia is a leading cause of death worldwide, ranking third both globally and in Taiwan. This guideline was prepared by the 2017 Guidelines Recommendations for Evidence-based Antimicrobial agents use in Taiwan (GREAT) working group, formed under the auspices of the Infectious Diseases Society of Taiwan (IDST). A consensus meeting was held jointly by the IDST, Taiwan Society of Pulmonary and Critical Care Medicine (TSPCCM), the Medical Foundation in Memory of Dr. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16841182183048
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http://dx.doi.org/10.1016/j.jmii.2018.11.004DOI Listing
February 2019
11 Reads

Characterize carbapenem-resistant Klebsiella pneumoniae isolates for nosocomial pneumonia and their Gram-negative bacteria neighbors in the respiratory tract.

Mol Biol Rep 2019 Jan 2. Epub 2019 Jan 2.

Department of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.

This study was conducted to perform an epidemiological survey of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates for nosocomial pneumonia (NP) and visit their Gram-negative bacteria neighbors (GNNs) from the respiratory tracts. Pulsed-field gel electrophoresis and multi locus sequence typing were performed to evaluate the clonal relationships of these isolates. Statistical methods were then used to understand their possible relationship between CRKP and their GNNs. Read More

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http://dx.doi.org/10.1007/s11033-018-4515-yDOI Listing
January 2019

Comparing current US and European guidelines for nosocomial pneumonia.

Curr Opin Pulm Med 2018 Dec 28. Epub 2018 Dec 28.

Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, Dublin, Ireland.

Purpose Of Review: In the last 2 years, two major guidelines for the management of nosocomial pneumonia have been published: The International European Respiratory Society/European Society of Intensive Care Medicine/European Society of Clinical Microbiology and Infectious Diseases/Asociación Latinoamericana de Toráx guidelines for the management of hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) and the American guidelines for management of adults with HAP and VAP; both the guidelines made important clinical recommendations for the management of patients.

Recent Findings: With the increasing emergence of multidrug resistant (MDR) organisms, paired with a relative reduction in new antibiotic development, nosocomial infections have become one of the most significant issues affecting global healthcare today. Despite several stark differences between the European and American guidelines, they are in agreement about many aspects of nosocomial pneumonia management. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000559DOI Listing
December 2018
2 Reads

Disease Burden and Etiologic Distribution of Community-Acquired Pneumonia in Adults: Evolving Epidemiology in the Era of Pneumococcal Conjugate Vaccines.

Infect Chemother 2018 Dec;50(4):287-300

Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Pneumonia is the leading cause of morbidity and mortality, particularly in old adults. The incidence and etiologic distribution of community-acquired pneumonia is variable both geographically and temporally, and epidemiology might evolve with the change of population characteristics and vaccine uptake rates. With the increasing prevalence of chronic medical conditions, a wide spectrum of healthcare-associated pneumonia could also affect the epidemiology of community-acquired pneumonia. Read More

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http://dx.doi.org/10.3947/ic.2018.50.4.287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312904PMC
December 2018
1 Read

Monitoring healthcare-associated infections and antimicrobial use at regional level through repeated point prevalence surveys: what can be learnt?

J Hosp Infect 2018 Dec 29. Epub 2018 Dec 29.

Department of Medicine, University of Udine, Udine, Italy; Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.

Background: Healthcare-associated infections (HAIs) surveillance is an essential part of any infection prevention and control programme. Repeated point prevalence surveys (PPSs) according to European Centre for Disease Prevention and Control (ECDC) protocol have been implemented in all Friuli Venezia Giulia (FVG) region (Italy) acute hospitals to reduce and control HAIs.

Aim: Using the repeated PPSs within a regional-healthcare system (RHS) to promote and evaluate infection prevention and control (IPC) programmes. Read More

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http://dx.doi.org/10.1016/j.jhin.2018.12.016DOI Listing
December 2018

[Effect of enteral nutrition tolerance assessment standardized process management on ventilator associated pneumonia and prognosis in patients with tracheotomy and long-term mechanical ventilation in intensive care unit].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Dec;30(12):1173-1177

Department of Cardiothoracic Surgery, Changzhou First People's Hospital, Changzhou 213003, Jiangsu, China. Corresponding author: Wang Bin, Email:

Objective: To investigate the effect of enteral nutrition (EN) tolerance assessment standardized process management on nosocomial infection and prognosis in patients with tracheotomy and long-term mechanical ventilation (MV) in intensive care unit (ICU).

Methods: A prospective cohort study was conducted. Forty-six patients who required long-term MV due to tracheotomy admitted to ICU of Changzhou First People's Hospital from January 2015 to December 2017 were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.012.014DOI Listing
December 2018
4 Reads

The potential economic value of sputum culture use in patients with community-acquired pneumonia and healthcare-associated pneumonia.

Clin Microbiol Infect 2018 Dec 24. Epub 2018 Dec 24.

Public Health Computational and Operations Research (PHICOR), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Global Obesity Prevention Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:

Objective: Despite numerous studies, the clinical value of sputum cultures in the management of pneumonia remains controversial; therefore, understanding the economic value of sputum cultures may help decision makers determine their appropriate use in patient management.

Methods: We developed a decision model to determine the economic and clinical value of using sputum cultures in the treatment of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP) from the hospital perspective under various conditions.

Results: For both CAP and HCAP patients, obtaining sputum cultures resulted in similar costs compared to no culture, even if cultures cost $0. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.11.031DOI Listing
December 2018
3 Reads
5.768 Impact Factor

Emergence and molecular characterization of multidrug-resistant isolates harboring extended-spectrum β-lactamases causing ventilator-associated pneumonia in China.

Infect Drug Resist 2019 20;12:33-43. Epub 2018 Dec 20.

Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China,

Background: Ventilator-associated pneumonia (VAP) is a common nosocomial infection associated with high morbidity due to multidrug-resistant (MDR) pathogens. The purpose of this study was to determine the occurrence of extended-spectrum β-lactamase (ESBL) genes, especially , in ()-associated VAP and to investigate the antimicrobial resistance patterns and molecular epidemiological characteristics of strains.

Materials And Methods: From January 2013 to December 2015, we retrospectively collected 89 VAP-causing isolates from tertiary-care hospitals in China, among which ESBL-producing strains were assessed for antimicrobial susceptibility. Read More

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https://www.dovepress.com/emergence-and-molecular-characteri
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http://dx.doi.org/10.2147/IDR.S189494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304254PMC
December 2018
6 Reads

The association between serum magnesium levels and community-acquired pneumonia 30-day mortality.

BMC Infect Dis 2018 Dec 27;18(1):698. Epub 2018 Dec 27.

The Rappaport's Faculty of Medicine, The Technion Institute, Haifa, Israel.

Background: Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide. Few studies have investigated the relationship between serum magnesium levels and outcomes of these patients. We aimed to study the association between serum magnesium levels and 30-day mortality among patients with CAP. Read More

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http://dx.doi.org/10.1186/s12879-018-3627-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307202PMC
December 2018
2 Reads

Risk factors for ventilator-associated events: A prospective cohort study.

Am J Infect Control 2018 Dec 22. Epub 2018 Dec 22.

Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Background: In January 2013, the Centers for Disease Control and Prevention released new surveillance definitions for ventilator-associated event (VAE) to replace ventilator-associated pneumonia (VAP) in adult patients. VAEs are associated with prolonged mechanical ventilation and hospital death, but little is known about their risk factors and how best to prevent them.

Methods: We compared VAE cases with non-VAE cases with regard to demographics, comorbidities, sedative exposures, opioids exposures, paralytic exposures, routes of nutrition, blood products, gastric retention, and fluid balance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01966553183098
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http://dx.doi.org/10.1016/j.ajic.2018.09.032DOI Listing
December 2018
8 Reads
2.206 Impact Factor

A lethal pneumonia model of Acinetobacter baumannii: an investigation in immunocompetent mice.

Clin Microbiol Infect 2018 Dec 22. Epub 2018 Dec 22.

Biopharm Research Institute of West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objectives: Acinetobacter baumannii can cause severe nosocomial and community-acquired pneumonia. To study the pathogenesis of A. baumannii and to develop new treatments, appropriate mouse models are needed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X183080
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http://dx.doi.org/10.1016/j.cmi.2018.12.020DOI Listing
December 2018
9 Reads

Endotracheal Tube Biofilm and its Impact on the Pathogenesis of Ventilator-Associated Pneumonia.

J Crit Care Med (Targu Mures) 2018 Apr 1;4(2):50-55. Epub 2018 Apr 1.

Anesthesia and Intensive Care Department, "Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania.

Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection in mechanically ventilated patients and results in high mortality, prolonged intensive care unit- (ICU) and hospital-length of stay and increased costs. In order to reduce its incidence, it is imperative to better understand the involved mechanisms and to identify the source of infection. The role of the endotracheal tube (ET) in VAP pathogenesis became more prominent over the last decades, along with extensive research dedicated to medical device-related infections and biofilms. Read More

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http://content.sciendo.com/view/journals/jccm/4/2/article-p5
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http://dx.doi.org/10.2478/jccm-2018-0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294989PMC
April 2018
10 Reads

Is intra-abdominal hypertension a risk factor for ventilator-associated pneumonia?

Ann Transl Med 2018 Nov;6(21):419

Department of Critical Care Medicine, University Hospital of Larisa, University of Thessaly School of Medicine, Larisa, Greece.

In the last years, there has been a significant amount of research about the impact of intra-abdominal hypertension (IAH) on the outcomes of critical care patients. IAH is increasingly recognized as potential complication in intensive care unit (ICU) patients. IAH affects all body systems, most notably the cardiac, respiratory, renal, and neurologic systems. Read More

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http://dx.doi.org/10.21037/atm.2018.08.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275402PMC
November 2018
1 Read

Lung ultrasound for diagnosis and monitoring of ventilator-associated pneumonia.

Ann Transl Med 2018 Nov;6(21):418

Anesthesia and Intensive Care, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection in intensive care units (ICU) and is associated with increased mortality, use of antimicrobials, longer mechanical ventilation, and higher healthcare costs. Lung ultrasonography (LUS) can be used at the bedside and gained widespread acceptance in ICU. Although the visualization of a single LUS sign cannot be considered specific for a diagnosis, clinically-driven LUS examination in particular setting and clinical conditions allow ruling in or out quickly and accurately several causes of acute respiratory failure. Read More

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http://dx.doi.org/10.21037/atm.2018.10.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275403PMC
November 2018
1 Read

Comparative proteomics analyses of Acinetobacter baumannii strains ATCC 17978 and AB5075 reveal the differential role of type II secretion system secretomes in lung colonization and ciprofloxacin resistance.

Microb Pathog 2019 Mar 20;128:20-27. Epub 2018 Dec 20.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. Electronic address:

Acinetobacter baumannii is an emerging nosocomial pathogen with alarming antibiotic resistance profiles. A better understanding of the virulence and resistance mechanisms of this pathogen is necessary for identifying new methods to combat its infections in a more efficient way. In this regard, the type II secretion system (T2SS) of A. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.12.039DOI Listing
March 2019
2 Reads
2.000 Impact Factor

A systematic review of healthcare-associated infections in Africa: An antimicrobial resistance perspective.

Afr J Lab Med 2018 6;7(2):796. Epub 2018 Dec 6.

Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun, Nigeria.

Background: Healthcare-associated infection (HCAI) is a global health challenge, not only as an issue of patient safety but also as a major driver of antimicrobial resistance (AMR). It is a major cause of morbidity and mortality with economic consequences.

Objective: This review provides an update on the occurrence of HCAI, as well as the contribution of emerging AMR on healthcare delivery in Africa. Read More

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http://dx.doi.org/10.4102/ajlm.v7i2.796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296034PMC
December 2018
2 Reads