5,431 results match your criteria Nosocomial Pneumonia


Predictors of mortality in patients infected with carbapenem-resistant Acinetobacter baumannii: A systematic review and meta-analysis.

Am J Infect Control 2019 Apr 16. Epub 2019 Apr 16.

Department of Respiratory Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) tops the list of threats to human health. Studies exploring predictors of mortality in patients with CRAB infection produced conflicting results.

Methods: A systematic search of the PubMed, Embase, and the Cochrane Library databases was performed from inception to June 2018 to identify studies reporting mortality predictors in patients infected with CRAB. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.03.003DOI Listing
April 2019
2 Reads

Ventilator-associated pneumonia and bloodstream infections in intensive care unit cancer patients: a retrospective 12-year study on 3388 prospectively monitored patients.

Support Care Cancer 2019 Apr 17. Epub 2019 Apr 17.

Service de Médecine Intensive Réanimation, Gustave Roussy, 114, rue Edouard Vaillant, Villejuif, 94805, France.

Purpose: Some publications suggest high rates of healthcare-associated infections (HAIs) and of nosocomial pneumonia portending a poor prognosis in ICU cancer patients. A better understanding of the epidemiology of HAIs in these patients is needed.

Methods: A retrospective analysis of all the patients hospitalized for ≥ 48 h during a 12-year period in the 12-bed ICU of the Gustave Roussy hospital, monitored prospectively for ventilator-associated pneumonia (VAP) and bloodstream infection (BSI) and for use of medical devices. Read More

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http://link.springer.com/10.1007/s00520-019-04800-6
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http://dx.doi.org/10.1007/s00520-019-04800-6DOI Listing
April 2019
1 Read

Drug Prevention and Control of Ventilator-Associated Pneumonia.

Front Pharmacol 2019 28;10:298. Epub 2019 Mar 28.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Ventilator-associated pneumonia (VAP) is one of the most prevalent and serious complications of mechanical ventilation, which is considered a common nosocomial infection in critically ill patients. There are some great options for the prevention of VAP: (i) minimize ventilator exposure; (ii) intensive oral care; (iii) aspiration of subglottic secretions; (iv) maintain optimal positioning and encourage mobility; and (v) prophylactic probiotics. Furthermore, clinical management of VAP depends on appropriate antimicrobial therapy, which needs to be selected based on individual patient factors, such as previous antibacterial therapy, history of hospitalization or mechanical ventilation, and bacterial pathogens and antibiotic resistance patterns. Read More

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http://dx.doi.org/10.3389/fphar.2019.00298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455059PMC

Point prevalence survey of healthcare-associated infections and antimicrobial use in Kosovo hospitals.

Infect Dis Rep 2019 Feb 19;11(1):7975. Epub 2019 Mar 19.

National Institute for Infectious Diseases "Lazzaro Spallanzani"- IRCCS, Rome, Italy.

Health care-associated infections (HAIs) and antimicrobial resistance constitute a major public health challenge. The aim of this study was to assess the prevalence rate of HAIs and antimicrobial use in acute care hospitals in Kosovo. A multicenter study was performed in all hospitals in Kosovo. Read More

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https://pagepress.org/journals/index.php/idr/article/view/79
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http://dx.doi.org/10.4081/idr.2019.7975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444376PMC
February 2019
3 Reads

Is hospital-acquired pneumonia different in transplant recipients?

Clin Microbiol Infect 2019 Apr 12. Epub 2019 Apr 12.

Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain; REIPI (Spanish Network for Research in Infectious Disease), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background: Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are serious complications in transplant patients.

Objectives: The aim of this review is to summarize the evidence regarding nosocomial pneumonia in transplant recipients, including HAP in non-ventilated patients and VAP, and to identify future directions for improvement.

Sources: A comprehensive literature search in the PubMed/MEDLINE database was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193015
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http://dx.doi.org/10.1016/j.cmi.2019.04.003DOI Listing
April 2019
2 Reads

The role of infection acquisition site and inappropriate empirical treatment on the outcome of extended-beta-lactamase producing Enterobacteriaceae infections.

Int J Antimicrob Agents 2019 Apr 12. Epub 2019 Apr 12.

Experimental and Clinical Medicine Department, Università degli Studi di Firenze, Florence, Italy; USC Microbiologia e Virologia, AOSP Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy; Institute of Infectious Diseases, Catholic University of Rome, Rome, Italy; Clinical Microbiology and Virology Unit, Alessandro Manzoni Hospital, Lecco, Italy; Infectious Diseases Department, Azienda Socio Sanitaria Territoriale di Cremona, Cremona, Italy; Emergency Department, Azienda Socio Sanitaria Territoriale di Cremona, Cremona, Italy; Microbiology and Virology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Objectives: The impact of inappropriate empirical antibiotic therapy (IEAT) on the outcome of severe infections due to extended spectrum beta-lactamases producers Enterobacteriaceae (ESBL-Ent) remains under debate. Current evidence is limited by study design and lacking confounder control. The main objective of this study was to define the outcome of severe infections due to ESBL-Ent according to clinical parameters and place of acquisition. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.04.007DOI Listing
April 2019
1 Read

Utility of Blood Cultures in Pneumonia.

Am J Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX; Division of Hospital Medicine, Chan Zuckerberg San Francisco General Hospital, University of California, San Francisco. Electronic address: https://twitter.com/anilmakam.

Introduction: Blood cultures are of limited utility in non-severe community-acquired pneumonia, though routinely recommended for severe community-acquired pneumonia or healthcare-associated pneumonia, due to perceived greater bacteremia risk, particularly with multidrug resistant organisms. The utility of this practice is unknown.

Methods: In this observational cohort study, we abstracted data from medical records for consecutive hospitalizations for pneumonia by adults to an academic medical center from 2014 to 2015. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.03.025DOI Listing
April 2019
1 Read

Infections in Cirrhosis.

Curr Treat Options Gastroenterol 2019 Apr 12. Epub 2019 Apr 12.

Division of Gastroenterology and Hepatology, University of Pennsylvania, 2 Dulles, 3400 Spruce Street, HUP, Philadelphia, PA, 19104, USA.

Purpose Of Review: Patients with cirrhosis are at high risk of developing serious infections. Bacterial infections remain the most common cause of morbidity and mortality in these patients. This review is focused on the prevalence of infections in those with cirrhosis, including multidrug-resistant (MDR) pathogens, pathogenesis of infection-related acute-on-chronic liver failure (ACLF), current treatment recommendations, and prophylactic strategies in patients with cirrhosis. Read More

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http://dx.doi.org/10.1007/s11938-019-00229-2DOI Listing
April 2019
1 Read

Molecular Epidemiology and Risk Factors of Ventilator-Associated Pneumonia Infection Caused by Carbapenem-Resistant Enterobacteriaceae.

Front Pharmacol 2019 22;10:262. Epub 2019 Mar 22.

Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

Ventilator-associated pneumonia (VAP) infection caused by carbapenem-resistant Enterobacteriaceae (CRE) is becoming more prevalent, thus seriously affecting patient outcomes. In this paper, we studied the drug resistance mechanism and epidemiological characteristics of CRE, and analyzed the infection and prognosis factors of VAP caused by CRE, to provide evidence for effective control of nosocomial infection in patients with VAP. A total of 58 non-repetitive CRE strains of VAP were collected from January 2016 to June 2018. Read More

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http://dx.doi.org/10.3389/fphar.2019.00262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439532PMC
March 2019
1 Read

Inhalation of specific anti-Pseudomonas aeruginosa IgY antibodies transiently decreases P. aeruginosa colonization of the airway in mechanically ventilated piglets.

Intensive Care Med Exp 2019 Apr 8;7(1):21. Epub 2019 Apr 8.

Hedenstierna laboratory, CIRRUS, Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Background: P. aeruginosa is a pathogen frequently resistant to antibiotics and a common cause of ventilator-associated pneumonia (VAP). Non-antibiotic strategies to prevent or treat VAP are therefore of major interest. Read More

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http://dx.doi.org/10.1186/s40635-019-0246-1DOI Listing
April 2019
1 Read

Mind the Coverage Gap: A PK-PD Evaluation of Ertapenem for Patients with Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia.

Antimicrob Agents Chemother 2019 Apr 8. Epub 2019 Apr 8.

Institute for Clinical Pharmacodynamics, Inc., Schenectady, NY, USA.

Ertapenem provides activity against many pathogens commonly associated with hospital-acquired and ventilator-associated bacterial pneumoniae (HABP and VABP, respectively), including methicillin-susceptible and numerous Gram-negative pathogens with one major gap in coverage - Pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses were conducted to evaluate ertapenem against the most prevalent Enterobacteriaceae causing HABP/VABP. The objective of these analyses was to provide dose selection support for and demonstrate the appropriateness of ertapenem to empirically treat patients with HABP/VABP when administered with murepavadin, a novel targeted antimicrobial exhibiting a highly specific spectrum of activity against A previously-developed population pharmacokinetic model, total-drug epithelial lining fluid to free-drug serum penetration ratio, contemporary surveillance data for ertapenem against Enterobacteriaceae, and %T>MIC targets associated with efficacy were used to conduct Monte Carlo simulations for five ertapenem regimens administered over short or prolonged durations of infusion. Overall total-drug ELF percent probabilities of PK-PD target attainment based on a %T>MIC target of 35% among simulated patients with HABP/VABP arising from Enterobacteriaceae based on pathogen prevalence data for nosocomial pneumonia ranged from 89. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.00318-19
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http://dx.doi.org/10.1128/AAC.00318-19DOI Listing
April 2019
2 Reads

Multidrug-resistant Pseudomonas aeruginosa and mortality inmechanically ventilated ICU patients.

Am J Infect Control 2019 Apr 6. Epub 2019 Apr 6.

Assistance Publique - Hôpitaux de Marseille, Hôpital Nord, Réanimation des Détresses Respiratoires et des Infections Sévères, Marseille, France; Aix-Marseille Université, School of Medicine - La Timone Medical Campus, CEReSS - Health Service Research and Quality of Life Center, Marseille, France.

Background: The link between bacterial resistance and prognosis remains controversial. Predominant pathogen causing ventilator-associated pneumonia (VAP) is Pseudomonas aeruginosa (Pa), which has increasingly become multidrug resistant (MDR). The aim of this study was to evaluate the relationship between MDR VAP Pa episodes and 30-day mortality. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.02.030DOI Listing
April 2019
3 Reads

Community-acquired Pneumonia and Hospital-acquired Pneumonia.

Med Clin North Am 2019 May 7;103(3):487-501. Epub 2019 Mar 7.

Division of Respiratory and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center, 1000 West Carson Street, Box 402, Torrance, CA 90509, USA.

Pneumonia is among the leading causes of morbidity and mortality worldwide. Although Streptococcus pneumoniae is the most likely cause in most cases, the variety of potential pathogens can make choosing a management strategy a complex endeavor. The setting in which pneumonia is acquired heavily influences diagnostic and therapeutic choices. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.12.008DOI Listing
May 2019
2 Reads

Increased Mortality from Extrapancreatic Infections in Hospitalized Patients with Acute Pancreatitis.

Gastroenterol Res Pract 2019 28;2019:2789764. Epub 2019 Feb 28.

National Institute of Medical Science and Nutrition Salvador Zubiran, Department of Gastroenterology, Mexico City, Mexico.

Nosocomial extrapancreatic infections in patients with acute pancreatitis (AP) are associated with a higher mortality even after adjusting the risk for the severity of the pancreatitis. The aim of this study was to describe the clinical features of hospitalized patients with AP who died during their hospitalization and to evaluate risk factors associated with mortality. We performed a descriptive study of the clinical features of adult patients who died from AP during their hospitalization and a case control study with a paired group of patients that survived AP during a 10-year period. Read More

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https://www.hindawi.com/journals/grp/2019/2789764/
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http://dx.doi.org/10.1155/2019/2789764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421823PMC
February 2019
4 Reads

Efficacy of bacteriophage treatment against carbapenem-resistant Acinetobacter baumannii in Galleria mellonella larvae and a mouse model of acute pneumonia.

BMC Microbiol 2019 Apr 2;19(1):70. Epub 2019 Apr 2.

Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Y, Seoul, Republic of Korea.

Background: Acinetobacter baumannii is an opportunistic pathogen that causes serious nosocomial infection in intensive care units. In particular, carbapenem-resistant A. baumannii (CRAB) strains have been increasing in the past decade, and they have caused major medical problems worldwide. Read More

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http://dx.doi.org/10.1186/s12866-019-1443-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444642PMC
April 2019
2 Reads

Risk Factors and Prevention Strategies of Nosocomial Infection in Geriatric Patients.

Can J Infect Dis Med Microbiol 2019 25;2019:6417959. Epub 2019 Feb 25.

Geriatrics Department, Zhongda Hospital Southeast University, No. 87, Dingjiaqiao, Nanjing, China.

Introduction: To investigate the risk factors of nosocomial infections (NIs) in geriatric department and the effectiveness of the proposed prevention strategy.

Methodology: We studied 3370 cases of elderly patients who were hospitalized more than 48 hours from January 2015 to December 2017 in the Geriatrics Department of Zhongda Hospital, Southeast University. In order to reduce the infection rate, nutritional risk screening (NRS 2002) was used to evaluate the nutritional status of the patients; enteral nutritional suspension (TPF-FOS) was provided to the patients who were assessed to be necessary. Read More

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http://dx.doi.org/10.1155/2019/6417959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410437PMC
February 2019
2 Reads

Increase in Infant Measles Deaths during a Nationwide Measles Outbreak - Mongolia, 2015-2016.

J Infect Dis 2019 Mar 29. Epub 2019 Mar 29.

Global Immunization Division, U.S. Centers for Disease Control and Prevention.

Background: Surveillance data from a large measles outbreak in Mongolia suggested an increased case fatality ratio (CFR) in the second of two waves. To confirm the increase in CFR and identify risk factors for measles death, we enhanced mortality ascertainment and conducted a case-control study among infants hospitalized for measles.

Methods: We linked national vital records with surveillance data of clinically- or laboratory-confirmed infant (aged <12 months) measles cases with rash onset during March-September 2015 (wave 1) and October 2015-June 2016 (wave 2). Read More

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http://dx.doi.org/10.1093/infdis/jiz140DOI Listing
March 2019
2 Reads
5.997 Impact Factor

Risk factors analysis of nosocomial pneumonia in elderly patients with acute cerebral infraction.

Medicine (Baltimore) 2019 Mar;98(13):e15045

Department of Clinical laboratory, TianJin First Hospital, China.

To investigate the risk factors of nosocomial pneumonia (NP) in elderly patients with acute cerebral infarction (ACI).In this study, 324 aged 70 years and over patients with ACI who were admitted to the inpatient department of TianJin First Hospital (China) from January 2012 to February 2018 were retrospectively analyzed. The patients were divided into NP group (80 patients) and non-NP group (244 patients) according to whether NP was occurred 48 hours after hospitalization. Read More

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http://dx.doi.org/10.1097/MD.0000000000015045DOI Listing
March 2019
1 Read

Risk factors for acquisition and mortality of multidrug-resistant Acinetobacter baumannii bacteremia: A retrospective study from a Chinese hospital.

Medicine (Baltimore) 2019 Mar;98(13):e14937

Department of Respiratory Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University.

Bloodstream infection caused by Acinetobacter baumannii has become a major clinical concern, especially multidrug-resistant A baumannii (MDRAB). The aim of this study was to identify the risk factors of nosocomial acquired MDRAB bacteremia and to determine the risk factors related to the mortality of patients with MDRAB bacteremia. Patients with nosocomial acquired A baumannii bacteremia were enrolled between January, 2013 and December, 2017 at the First Affiliated Hospital, School of Medicine, Zhejiang University. Read More

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http://dx.doi.org/10.1097/MD.0000000000014937DOI Listing
March 2019
1 Read

High Genetic Diversity among Isolates from Single Hospital: Nosocomial Outbreaks or Genotypic Profile Changes during Subcultures.

Malays J Med Sci 2018 Mar 27;25(2):40-49. Epub 2018 Apr 27.

Near East University, Department of Clinical Microbiology and Infections Diseases, Nicosia, Cyprus.

Background: is a non-fermentative gram-negative bacillus which is widely recognised as an important nosocomial pathogen causing pneumonia, blood-stream, wound and urinary tract infections, particularly in immunosuppressed patients. The aim of this study was to evaluate a nosocomial outbreak of by in an intensive care unit of a tertiary hospital and evaluate unexpected multiclonality.

Methods: A total of 11 isolates from respiratory cultures in intensive care unit of a 24 bed tertiary hospital obtained over a one months period and one isolate obtained from the nebuliser during environmental screening were investigated. Read More

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http://dx.doi.org/10.21315/mjms2018.25.2.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422583PMC
March 2018
1 Read

Rapid, specific, and sensitive detection of the ureR_1 gene in Klebsiella pneumoniae by loop-mediated isothermal amplification method.

Braz J Med Biol Res 2019 Mar 25;52(3):e8186. Epub 2019 Mar 25.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.

Klebsiella pneumoniae is one of the main pathogenic bacteria that causes nosocomial infections, such as pneumonia, urinary tract infection, and sepsis. Therefore, the rapid and accurate detection of K. pneumoniae is important for the timely treatment of infectious patients. Read More

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http://dx.doi.org/10.1590/1414-431X20198186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437934PMC
March 2019
2 Reads

Carbapenem-resistant Acinetobacter baumannii: in pursuit of an effective treatment.

Clin Microbiol Infect 2019 Mar 23. Epub 2019 Mar 23.

First Department of Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) has gained global notoriety as a critically important nosocomial pathogen. It mostly affects debilitated patients, causing pneumonia and bloodstream infections with high mortality rates. Difficulties in treating CRAB infections stem from a formidable resistance profile that leaves available only a few antibiotics of uncertain efficacy such as colistin and tigecycline. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.03.014DOI Listing
March 2019
1 Read

Prevalence of healthcare-associated infections and antimicrobial resistance in Kyiv acute care hospitals, Ukraine.

J Hosp Infect 2019 Mar 22. Epub 2019 Mar 22.

The Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine.

Background: Healthcare-associated infections (HAIs) are one of the commonest adverse events in patient care and account for substantial morbidity and mortality.

Aim: To obtain the first estimates of the current prevalence of HAIs and antimicrobial resistance in acute care hospitals in Kyiv, Ukraine.

Methods: Prospective surveillance was conducted from January 2014 to December 2016 in five Kyiv acute care hospitals. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.03.008DOI Listing
March 2019
1 Read

Stress ulcer prophylaxis in critically ill children: Protocol for a systematic review.

Acta Anaesthesiol Scand 2019 Mar 25. Epub 2019 Mar 25.

Department of Intensive Care, 4131, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Background: Stress ulcer prophylaxis is the considered standard of care in many critically ill patients in the intensive care unit (ICU). Whether there is overall benefit or harm of stress ulcer prophylaxis in critically ill children is unknown. Accordingly, we aim to assess patient-important benefits and harms of stress ulcer prophylaxis versus placebo or no treatment in critically ill children in the ICU. Read More

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http://dx.doi.org/10.1111/aas.13361DOI Listing
March 2019
1 Read

Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study.

Health Technol Assess 2019 Mar;23(11):1-70

School of Population Health and Environmental Sciences, King's College London, London, UK.

Background: Unnecessary prescribing of antibiotics in primary care is contributing to the emergence of antimicrobial drug resistance.

Objectives: To develop and evaluate a multicomponent intervention for antimicrobial stewardship in primary care, and to evaluate the safety of reducing antibiotic prescribing for self-limiting respiratory infections (RTIs).

Interventions: A multicomponent intervention, developed as part of this study, including a webinar, monthly reports of general practice-specific data for antibiotic prescribing and decision support tools to inform appropriate antibiotic prescribing. Read More

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http://dx.doi.org/10.3310/hta23110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452237PMC
March 2019
3 Reads

Pectin-containing liquid enteral nutrition for critical care: a historical control and propensity score matched study.

Asia Pac J Clin Nutr 2019 ;28(1):57-63

Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Tokyo, Japan.

Background And Objectives: Pectin-containing liquid enteral nutrition (PCLEN) contains pectin, which becomes solid in the stomach and therefore mitigates vomiting and diarrhea. Its efficacy for use in critical care medicine was evaluated.

Methods And Study Design: We used liquid enteral nutrition (LEN) (traditional LEN (TLEN)) as the primary LEN at the emergency and critical care center. Read More

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http://dx.doi.org/10.6133/apjcn.201903_28(1).0009DOI Listing
January 2019
1 Read

Twenty-Year Trends in Antimicrobial Susceptibilities Among From the SENTRY Antimicrobial Surveillance Program.

Open Forum Infect Dis 2019 Mar 15;6(Suppl 1):S47-S53. Epub 2019 Mar 15.

JMI Laboratories, North Liberty, Iowa.

Background: is among the most common human pathogens, with therapy complicated by the epidemic spread of methicillin-resistant (MRSA).

Methods: The SENTRY Antimicrobial Surveillance Program evaluated the in vitro activity of >20 antimicrobials against 191 460 clinical isolates collected from 427 centers in 45 countries from 1997 to 2016. Each center contributed isolates and clinical data for consecutive episodes of bacteremia, pneumonia in hospitalized patients, urinary tract infection, and skin and skin structure infection. Read More

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http://dx.doi.org/10.1093/ofid/ofy270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419894PMC
March 2019
1 Read

Rapid, Visual Detection of Using Magnetic Nanoparticles and an Horseradish Peroxidase-Probe Based Immunosensor.

J Biomed Nanotechnol 2019 May;15(5):1061-1071

is a common human pathogen that causes several nosocomial chronic infections. Many methods have been reported to detect ; however, a simple, rapid, and visual method remains to be developed. Here, we developed a rapid, visual detection method employing a nanoparticle immunosensor (NPIS) with a sensitivity of 8 CFU mL. Read More

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http://dx.doi.org/10.1166/jbn.2019.2736DOI Listing
May 2019
3 Reads
5.338 Impact Factor

Infections and outcomes after cardiac surgery-The impact of outbreaks traced to transesophageal echocardiography probes.

Acta Anaesthesiol Scand 2019 Mar 19. Epub 2019 Mar 19.

Department of Anaesthesia and Intensive Care, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.

Background: Infections are a frequent complication of cardiac surgery. The intraoperative use of transesophageal echocardiography (TEE) may be an underrecognized risk factor for post-operative infections. The aim of this study was to investigate infection rates and outcomes after cardiac surgery in a nationwide cohort, especially in relation to periods where surface damaged TEE probes were used. Read More

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http://dx.doi.org/10.1111/aas.13360DOI Listing
March 2019
2 Reads

A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia.

Antibiotics (Basel) 2019 Mar 16;8(1). Epub 2019 Mar 16.

Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Room 164 (M/C 886), Chicago, IL 60612, USA.

Despite advancements in therapy, pneumonia remains the leading cause of death due to infectious diseases. Novel treatment strategies are desperately needed to optimize the antimicrobial therapy of patients suffering from this disease. One such strategy that has recently garnered significant attention is the use of inhaled antibiotics to rapidly achieve therapeutic concentrations directly at the site of infection. Read More

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http://dx.doi.org/10.3390/antibiotics8010027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466860PMC

Nebulized Amikacin and Fosfomycin for Severe Pseudomonas aeruginosa Pneumonia: An Experimental Study.

Crit Care Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Pulmonary and Critical Care Medicine, Hospital Clinic, Barcelona, Spain.

Objectives: Latest trials failed to confirm merits of nebulized amikacin for critically ill patients with nosocomial pneumonia. We studied various nebulized and IV antibiotic regimens in a porcine model of severe Pseudomonas aeruginosa pneumonia, resistant to amikacin, fosfomycin, and susceptible to meropenem.

Design: Prospective randomized animal study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003724DOI Listing
March 2019
8 Reads

Triple combination therapy with high-dose ampicillin/sulbactam, high-dose tigecycline and colistin in the treatment of ventilator-associated pneumonia caused by pan-drug resistant Acinetobacter baumannii: a case series study.

Infez Med 2019 Mar;27(1):11-16

Department of Internal Medicine, Division of Infectious Diseases, University of Patras Medical School, Patras, Greece.

Acinetobacter baumannii has evolved in recent decades as a major problem in carbapenem-resistant gram-negative nosocomial infections, associated with high mortality rates especially in intensive care units (ICUs). Recent reports highlight the increasing prevalence of resistance to colistin, a last resort therapeutic option for carbapenem-resistant A. baumannii. Read More

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March 2019
2 Reads

Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014.

Emerg Infect Dis 2019 Apr;25(4):710-718

In a prospective, nationwide study in France of Escherichia coli responsible for pneumonia in patients receiving mechanical ventilation, we determined E. coli antimicrobial susceptibility, phylotype, O-type, and virulence factor gene content. We compared 260 isolates with those of 2 published collections containing commensal and bacteremia isolates. Read More

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http://dx.doi.org/10.3201/eid2504.180944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433033PMC
April 2019
2 Reads

Unusual presentation of late-onset disseminated staphylococcal sepsis in a preterm infant.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Neonatal Intensive Care Unit, St Mary's Hospital, Manchester, UK.

An ex-30-week gestation, preterm male baby was admitted to a tertiary neonatal unit and noted to have increased ventilator requirements and diagnosed with sepsis. The baby also developed an abscess over the left elbow and over the xiphisternum along with a decrease in movement of the left hand and the right leg. Panton-Valentine leukocidin (PVL)-producing (SA) was isolated from the blood culture. Read More

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http://dx.doi.org/10.1136/bcr-2018-226325DOI Listing
March 2019
1 Read

Pulmonary infections prime the development of subsequent ICU-acquired pneumonia in septic shock.

Ann Intensive Care 2019 Mar 15;9(1):39. Epub 2019 Mar 15.

Service de médecine intensive-réanimation, Hôpital Cochin, Hôpitaux Universitaires Paris-Centre, Assistance Publique - Hôpitaux de Paris, 27 Rue du Faubourg Saint-Jacques, 75014, Paris, France.

Purpose: To investigate the determinants and the prognosis of intensive care unit (ICU)-acquired pneumonia in patients with septic shock.

Methods: This single-center retrospective study was conducted in a medical ICU in a tertiary care center from January 2008 to December 2016. All consecutive patients diagnosed for septic shock within the first 48 h of ICU admission were included. Read More

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http://dx.doi.org/10.1186/s13613-019-0515-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420540PMC
March 2019
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Epidemiological, clinical, and microbiological characteristics of carbapenemase-producing Enterobacteriaceae bloodstream infection in the Republic of Korea.

Antimicrob Resist Infect Control 2019 5;8:48. Epub 2019 Mar 5.

Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 59, Daesagwan-ro, Yongsan-gu, Seoul, 04401 Republic of Korea.

Background: Carbapenemase-producing Enterobacteriaceae (CPE) is an important pathogen in nosocomial infections; nevertheless, only a few studies regarding CPE infection and its epidemiological factors have been conducted in the Republic of Korea (ROK). We aimed to analyze the clinical, microbiological, and epidemiological characteristics of CPE bloodstream infections (BSIs) in the ROK.

Methods: This retrospective cohort study included data collected from the National Surveillance System from January 2015 to December 2016 based on the epidemiologic survey performed by an epidemiologist from the Korea Centers for Disease Control and Prevention. Read More

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https://aricjournal.biomedcentral.com/articles/10.1186/s1375
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http://dx.doi.org/10.1186/s13756-019-0497-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402157PMC
March 2019
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Epidemiology of Surgical Site Infections and Non-Surgical Infections in Neurosurgical Polish Patients-Substantial Changes in 2003⁻2017.

Int J Environ Res Public Health 2019 Mar 13;16(6). Epub 2019 Mar 13.

Department of Microbiology, Faculty of Medicine, Jagiellonian University Collegium Medicum, 31-121 Kraków, Poland.

: The objective of the analysis was to determine the epidemiology of healthcare-associated infections (HAIs) in neurosurgical patients, paying special attention to two time points, 2003 and 2017, in order to evaluate the effectiveness of a surveillance program introduced in 2003 and efforts to reduce infection rates. : Continuous surveillance during 2003⁻2017 carried out using the HAI-Net methodology allowed us to detect 476 cases of HAIs among 10,332 patients staying in a 42-bed neurosurgery unit. The intervention in this before⁻after study (2003⁻2017) comprised standardized HAI surveillance with regular analysis and feedback. Read More

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http://dx.doi.org/10.3390/ijerph16060911DOI Listing

Community Acquired Legionnaire's Disease in a Kidney Transplant Patient.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):45-49

Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, Zagreb, Croatia.

This case report details the clinical picture of a renal transplant recipient infected with community acquired Legionella pneumonia. While it is more commonly associated as a nosocomial infection due to pathogenic organisms in a hospital's water supply, this case serves as a reminder to consider the patient's impaired cellular immune function when trying to diagnose community acquired pneumonia. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0041DOI Listing
December 2018

[Clinical observation on application of different enteral nutrition preparations in patients with severe traumatic brain injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Feb;31(2):209-213

Department of Critical Care Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China. Corresponding author: Wang Difen, Email:

Objective: To observe the effects of enteral nutrition (EN) emulsion with different components on nutritional index, blood glucose, inflammatory reaction, gastrointestinal tolerance and prognosis in patients with severe traumatic brain injury (sTBI).

Methods: Patients with sTBI [Glasgow coma scale (GCS) < 8] admitted to intensive care unit (ICU) of Affiliated Hospital of Guizhou Medical University from January 2016 to May 2018 were retrospectively analyzed. These patients had received EN, 30 cases of them were fed with Baipuli, 35 cases were fed with Ruineng, and 30 cases were fed with Ruisu. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.02.017DOI Listing
February 2019
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Adherence to antibiotic guidelines and reported penicillin allergy: pooled cohort data on prescribing and allergy documentation from two English National Health Service (NHS) trusts.

BMJ Open 2019 Mar 1;9(2):e026624. Epub 2019 Mar 1.

Imperial College Healthcare NHS Trust, London, UK.

Objective: To investigate documentation of antimicrobial allergy and to determine prescribing adherence to local antibiotic guidelines for inpatients with and without reported penicillin allergy treated for infection in a National Health Service (NHS) context.

Setting: Data were collected at two English hospital NHS trusts over two time-periods: June 2016 and February 2017.

Design: Cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398633PMC
March 2019
8 Reads

Healthcare-associated pneumonia: is there any reason to continue to utilize this label in 2019?

Clin Microbiol Infect 2019 Feb 27. Epub 2019 Feb 27.

Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.

Background: There is an ongoing controversy on the role of the healthcare-associated pneumonia (HCAP) label in the treatment of patients with pneumonia.

Objective: To provide an update of the literature on patients meeting criteria for HCAP between 2014 and 2018.

Sources: The review is based on a systematic literature search using PubMed-Central full-text archive of biomedical and life sciences literature at the U. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.022DOI Listing
February 2019
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Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines.

BMJ 2019 02 27;364:l440. Epub 2019 Feb 27.

Modelling and Economics Unit, National Infection Service, Public Health England, London NW9 5EQ, UK.

Objective: To evaluate the duration of prescriptions for antibiotic treatment for common infections in English primary care and to compare this with guideline recommendations.

Design: Cross sectional study.

Setting: General practices contributing to The Health Improvement Network database, 2013-15. Read More

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http://dx.doi.org/10.1136/bmj.l440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391655PMC
February 2019
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Characterization of Clinically Relevant Strains of Extended-Spectrum β-Lactamase-Producing Occurring in Environmental Sources in a Rural Area of China by Using Whole-Genome Sequencing.

Front Microbiol 2019 12;10:211. Epub 2019 Feb 12.

Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

is a gram-negative, opportunistic pathogen, and a common cause of healthcare-associated infections such as pneumonia, septicemia, and urinary tract infection. The purpose of this study was to survey the occurrence of and characterize in different environmental sources in a rural area of Shandong province, China. Two hundred and thirty-one samples from different environmental sources in 12 villages were screened for extended-spectrum β-lactamase-(ESBL)-producing , and 14 (6%) samples were positive. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379450PMC
February 2019
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Genomic epidemiology of severe community-onset Acinetobacter baumannii infection.

Microb Genom 2019 Mar 26;5(3). Epub 2019 Feb 26.

1​Global and Tropical Health Division, Menzies School of Health Research, Darwin 0810, Australia.

Acinetobacter baumannii causes severe, fulminant, community-acquired pneumonia (CAP) in tropical and subtropical regions. We compared the population structure, virulence and antimicrobial resistance determinants of northern Australian community-onset A. baumannii strains with local and global strains. Read More

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http://dx.doi.org/10.1099/mgen.0.000258DOI Listing
March 2019
4 Reads

Global Metabolic Analyses of Acinetobacter baumannii.

Methods Mol Biol 2019 ;1946:321-328

Laboratory of Antimicrobial Systems Pharmacology, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.

Acinetobacter baumannii is rapidly emerging as a multidrug-resistant pathogen responsible for nosocomial infections including pneumonia, bacteremia, wound infections, urinary tract infections, and meningitis. Metabolomics provides a powerful tool to gain a system-wide snapshot of cellular biochemical networks under defined conditions and has been increasingly applied to bacterial physiology and drug discovery. Here we describe an optimized sample preparation method for untargeted metabolomics studies in A. Read More

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http://dx.doi.org/10.1007/978-1-4939-9118-1_28DOI Listing
January 2019
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Performance of the extended use of the FilmArray BCID panel kit for bronchoalveolar lavage analysis.

Mol Biol Rep 2019 Feb 23. Epub 2019 Feb 23.

Laboratoire de Bactériologie, CHU Angers, 4 rue Larrey, 49933, Angers cedex, France.

Ventilator-associated pneumonia (VAP) are responsible for an increase in morbidity, mortality, and prolonged hospital stay. A multiplex PCR kit such as the FilmArray BCID panel could allow early adaptation of antimicrobial therapy, which is crucial for clinical outcomes. The purpose of this study was to test the performances of FilmArray BCID panel for the detection of bacteria producing VAP. Read More

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http://dx.doi.org/10.1007/s11033-019-04710-0DOI Listing
February 2019
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Aspiration Pneumonia in Older Adults.

J Hosp Med 2019 Feb 20;14:E1-E7. Epub 2019 Feb 20.

Northwell Health, Manhasset, New York.

Aspiration pneumonia refers to an infection of the lung parenchyma in an individual that has inhaled a bolus of endogenous flora that overwhelms the natural defenses of the respiratory system. While there are not universally agreed upon criteria, the diagnosis can be made in patients with the appropriate risk factors and clinical scenario, in addition to a radiographic or an ultrasonographic image of pneumonia in the typical dependent lung segment. Treatment options for aspiration pneumonia vary based on the site of acquisition (community-acquired aspiration pneumonia [CAAP] versus healthcare-associated aspiration pneumonia [HCAAP]), the risk for multidrug-resistant (MDR) organisms, and severity of illness. Read More

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http://dx.doi.org/10.12788/jhm.3154DOI Listing
February 2019
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Implementation of infection prevention and control in acute care hospitals in Mainland China - a systematic review.

Antimicrob Resist Infect Control 2019 11;8:32. Epub 2019 Feb 11.

Infection Control Program and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211 Geneva 14, Switzerland.

Background: Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) affect patients in acute-care hospitals worldwide. No systematic review has been published on adoption and implementation of the infection prevention and control (IPC) key components. The objective of this systematic review was to assess adoption and implementation of the three areas issued by the "National Health Commission of the People's Republic of China" in acute-care hospitals in Mainland China, and to compare the findings with the key and core components on effective IPC, issued by the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1186/s13756-019-0481-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371478PMC
February 2019
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Infections in Neonatal Intensive Care Units (NICUs).

Int J Environ Res Public Health 2019 02 20;16(4). Epub 2019 Feb 20.

Department of Health Sciences, University of Genoa, Italy Via Pastore, 1-16132 Genoa, Italy.

belongs to the family Enterobacteriaceae, which is commonly found in water, soil, animals, insects, plants. Although displays relatively low virulence, it causes nosocomial infections and outbreaks in severely immunocompromised or critically ill patients, particularly in settings such as intensive care units (ICUs), especially neonatal units (NICUs). This microorganism gives rise to a wide range of clinical manifestations in newborns: from asymptomatic colonization to keratitis, conjunctivitis, urinary tract infections, pneumonia, surgical wound infections, sepsis, bloodstream infection and meningitis. Read More

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http://dx.doi.org/10.3390/ijerph16040610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406414PMC
February 2019
1 Read