28,651 results match your criteria Nosocomial Pneumonia


Draft genome sequence of human-associated streptogramin resistant Staphylococcus aureus.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Bacterial Epidemiology and Antimicrobial Resistance Research Unit, USDA-ARS, Athens, Georgia, USA. Electronic address:

Objectives: Staphylococcus aureus is one of the leading causes of nosocomial and community-acquired infections. Treatment of those infections with macrolide-lincosamide-streptogramin (MLS) antibiotics has led to resistance to those antibiotics through various mechanisms. S. Read More

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December 2018
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Draft genome sequence of Escherichia coli ST410 co-harboring bla, bla, bla, aac(3)-IIa, aac(6')-Ib-cr genes with gyrA and parC mutations isolated from pediatric patient in Poland.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Department of Bacteriology and Biocontamination Control, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland.

Objectives: Escherichia coli is one of the major agents of nosocomial infections. The aim of this study was to report the first draft genome sequence of an E. coli strain (no. Read More

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December 2018
2 Reads

First report of two consecutive respiratory syncytial virus outbreaks by the novel genotypes ON-1 and NA-2 in a neonatal intensive care unit.

J Pediatr (Rio J) 2018 Dec 12. Epub 2018 Dec 12.

Santa Casa de São Paulo, Unidade de Doenças Infecciosas Pediátricas, São Paulo, SP, Brazil.

Objective: Respiratory syncytial virus is a pathogen frequently involved in nosocomial outbreaks. Although several studies have reported nosocomial outbreaks in neonatal intensive care units, molecular epidemiology data are scarce. Here, the authors describe two consecutive respiratory syncytial virus outbreaks caused by genotypes ON-1 and NA-2 in a neonatal intensive care unit in São Paulo, Brazil. Read More

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December 2018

Colistin and polymyxin B for treatment of nosocomial infections in intensive care unit patients: pharmacoeconomic analysis.

Int J Clin Pharm 2018 Dec 15. Epub 2018 Dec 15.

Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Cândido Portinari 200, 13083-871, Campinas, SP, Brazil.

Background The emergence and rapid spread of multidrug-resistant gram-negative bacteria related to nosocomial infections is a growing worldwide problem, and polymyxins have become important due to the lack of new antibiotics. Objectives To evaluate the outcomes and pharmacoeconomic impact of using colistin and polymyxin B to treat nosocomial infections. Setting Neurosurgical, cardiovascular, or transplantation intensive care unit (ICU) at the Clinical Hospital of the University of Campinas (São Paulo, Brazil). Read More

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December 2018

Characterization of an NDM-19-producing Klebsiella pneumoniae strain harboring 2 resistance plasmids from China.

Diagn Microbiol Infect Dis 2018 Nov 20. Epub 2018 Nov 20.

Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou 646000, Sichuan, China. Electronic address:

Carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a major cause of nosocomial infections and posed challenges on clinical treatments. The main objective of this study was to determinate the genetic characteristics of the NDM-19-producing CRKP strain SCM96. From 2015 to 2017, 18 CRKP strains were recovered from sputum samples of patients in respiratory medicine in 6 hospitals from 5 provinces and cities in China. Read More

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November 2018

Clinical, immunological and bacteriological characteristics of H7N9 patients nosocomially co-infected by Acinetobacter Baumannii: a case control study.

BMC Infect Dis 2018 Dec 14;18(1):664. Epub 2018 Dec 14.

Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, 518112, China.

Background: Bacterial co-infection of patients suffering from influenza pneumonia is a key element that increases morbidity and mortality. The occurrence of Acinetobacter baumannii co-infection in patients with avian influenza A (H7N9) virus infection has been described as one of the most prevalent bacterial co-infections. However, the clinical and laboratory features of this entity of H7N9 and A. Read More

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December 2018

Ventilator-associated pneumonia: The central role of transcolonization.

J Crit Care 2018 Dec 6;50:155-161. Epub 2018 Dec 6.

Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France; Endotoxins, Structures and Host Response, Department of Microbiology, Institute for Integrative Biology of the Cell, UMR 9891 CNRS-CEA-Paris Saclay University, 98190 Gif-sur-Yvette, France. Electronic address:

Ventilator-associated pneumonia remain frequent and serious diseases since they are associated with considerable crude mortality. Pathophysiology is centered on modifications of regional bacterial flora, especially tracheobronchial tree and oropharyngeal sphere. Bacterial migration from an anatomical area to another seems to be the main explanation of these alterations which are called "transcolonization". Read More

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December 2018
2 Reads

Identification of putative non-host essential genes and novel drug targets against Acinetobacter baumannii by in silico comparative genome analysis.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry, Abdul Wali Khan University, Mardan, Pakistan.

Acinetobacter baumannii, the gram-negative bacteria emerged as an extremely critical pathogen causing nosocomial and different kinds of infections. A. baumannii exhibit resistivity towards various classes of antibiotics that shows that there is a dire need to search more drug targets by exploiting the full genome of the bacteria. Read More

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December 2018

Increasing prevalence of the epidemic ribotype 106 in healthcare facility-associated and community-associated Clostridioides difficile infection.

Anaerobe 2018 Dec 11. Epub 2018 Dec 11.

Microbiology Department, Hospital Universitari Son Espases and Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain. Electronic address:

Clostridioides difficile is the leading cause of nosocomial diarrhea and antibiotics associated diarrhea, but it is also an increasingly common cause of community diarrhea. In recent years we have observed a progressive increase in the incidence of C. difficile infection (CDI) both at the hospital and community setting that could be explained by the dynamic epidemiology of C. Read More

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December 2018

Emergence of High-level Gentamicin Resistance among Clinical Isolates from Burn Patients in South-west of Iran: Vancomycin Still Working.

Pol J Microbiol 2018 ;67(4):401-406

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Enterococcus faecalis and Enterococcus faecium are among the main agents associated with nosocomial infections with high mortality in immunocompromised patients. Antibiotic resistance, especially against gentamicin and vancomycin among Enterococci , is a risk factor that could increase the morbidity and mortality rate. 179 Enterococci isolates from burn patients were included in this study. Read More

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January 2018

Biochemical Characterization of AroH, a Putative Aromatic Amino Acid Aminotransferase.

Front Mol Biosci 2018 28;5:104. Epub 2018 Nov 28.

Department of Experimental Medicine, University of Perugia, Perugia, Italy.

The rise in the frequency of nosocomial infections is becoming a major problem for public health, in particular in immunocompromised patients. is an opportunistic fungus normally present in the environment directly responsible for lethal invasive infections. Recent results suggest that the metabolic pathways related to amino acid metabolism can regulate the fungus-host interaction and that an important role is played by enzymes involved in the catabolism of L-tryptophan. Read More

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November 2018
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Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR .

Comput Struct Biotechnol J 2018 10;16:587-599. Epub 2018 Nov 10.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville 3010, VIC, Australia.

Polymyxins are amongst the most important antibiotics in modern medicine, in recent times their clinical utility has been overshadowed by nosocomial outbreaks of polymyxin resistant MDR Gram-negative 'superbugs'. An effective strategy to surmount polymyxin resistance is combination therapy with FDA-approved non-antibiotic drugs. Herein we used untargeted metabolomics to investigate the mechanism(s) of synergy between polymyxin B and the selective estrogen receptor modulator (SERM) tamoxifen against a polymyxin-resistant MDR cystic fibrosis (CF) FADDI-PA006 isolate (polymyxin B MIC=8 mg/L , it is an MDR polymyxin resistant isolated from the lungs of a CF patient). Read More

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November 2018

Early Inflammatory Markers for the Diagnosis of Late-Onset Sepsis in Neonates: The Nosodiag Study.

Front Pediatr 2018 13;6:346. Epub 2018 Nov 13.

Service de Pédiatrie II, Hôpital de Hautepierre, Strasbourg, France.

Early diagnosis is essential to improve the treatment and prognosis of newborn infants with nosocomial bacterial infections. Although cytokines and procalcitonin (PCT) have been evaluated as early inflammatory markers, their diagnostic properties have rarely been compared. This study evaluated and compared the ability of individual inflammatory markers available for clinician (PCT, semi-quantitative determination of IL-8) and of combinations of markers (CRP plus IL-6 or quantitative or semi-quantitative determination of IL-8) to diagnose bacterial nosocomial infections in neonates. Read More

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November 2018

Abnormal expression of miR-4784 in chondrocytes of osteoarthritis and associations with chondrocyte hyperplasia.

Exp Ther Med 2018 Dec 14;16(6):4690-4694. Epub 2018 Sep 14.

Department of General Dentistry, The 174th Hospital of Chinese PLA, Chenggong Hospital Affiliated to Medical College of Xiamen University, Xiamen, Fujian 361003, P.R. China.

The aim of the present study was to assess the expression of microRNA (miRNA)-4784 in the chondrocytes of early osteoarthritis (OA) and to determine the effect of double-stranded (ds)-miRNA-4784 transfection on chondrocyte function. Following the construction of an OA rabbit model, normal chondrocytes (normal control group), OA chondrocytes obtained 4 weeks after modeling (OA at week 4 group) and 8 weeks after modeling (OA at week 8 group) were used. The relative expression of miRNA-4784 in each group was detected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Read More

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December 2018

Genomic Analysis of Consecutive Strains From a Single Patient.

Front Microbiol 2018 27;9:2840. Epub 2018 Nov 27.

Department of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.

is one of the most important nosocomial pathogens, and thus it is required to investigate how it disseminate in hospitals and infect patients. We performed whole genome sequencing for 24 strains isolated successively from the blood of a single patient to evaluate whether repeated infections were due to re-infection or relapse infection and to investigate within-host evolution. The whole genome of the first strain, BL1, was sequenced using the PacBio RSII system. Read More

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November 2018

Complete Genome Sequence of -Positive sp. MRY16-398 Isolate From the Ascites of a Diverticulitis Patient.

Front Microbiol 2018 22;9:2853. Epub 2018 Nov 22.

Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan.

A novel species of carbapenemase-producing Enterobacteriaceae (CPE) was isolated from a patient diagnosed with sigmoid colon diverticulitis. At first, laboratory testing suggested it was or sp.; however, a complete genome sequence of the isolate, MRY16-398, revealed that it could be novel species, most similar to [] , of which taxonomic nomenclature is still under discussion. Read More

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November 2018

The Importance of Acinetobacter Species in the Hospital Environment.

Med Arch 2018 Nov;72(5):325-329

Clinical for Nephrology, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina.

Introduction: species is associated with health care associated infections especially in patients on respiratory therapy equipment and indwelling catheters. They are becoming increasingly drug resistant. The knowledge of the prevalence and pattern of antimicrobial susceptibility pattern of Acinetobacter spp. Read More

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November 2018

APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment?

Hepatol Int 2018 Dec 11. Epub 2018 Dec 11.

Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi, Kofu-shi, Yamanashi, 400-8506, Japan.

Chronic hepatitis C virus (HCV) infection is common among patients with chronic kidney disease (CKD) and those on hemodialysis due to nosocomial infections and past blood transfusions. While a majority of HCV-infected patients with end-stage renal disease are asymptomatic, some may ultimately experience decompensated liver diseases and hepatocellular carcinoma. Administration of a combination of elbasvir/grazoprevir for 12 weeks leads to high sustained virologic response (SVR) rates in patients with HCV genotypes (GTs) 1a, 1b or 4 and stage 4 or 5 CKD. Read More

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December 2018

A study on biofilm production and antifungal drug resistance among Candida species from vulvovaginal and bloodstream infections.

Infect Drug Resist 2018 23;11:2443-2448. Epub 2018 Nov 23.

Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, Manipal, India.

Introduction: species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various species and slime production by species in BSIs and vulvovaginal candidiasis (VVC).

Materials And Methods: A total of 176 samples were collected for a period of 1 year. Read More

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November 2018

Bionomics of phlebotomine sand flies species (Diptera: Psychodidae) and their natural infection with and in Fars province, southern Iran.

J Parasit Dis 2018 Dec 22;42(4):511-518. Epub 2018 Aug 22.

5Research Center for Health Sciences, Institute of Health, Department of Medical Entomology and Vector Control, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Phlebotominae sand flies are involved in human diseases, such as leishmaniasis, and cause a considerable number of deaths every year. Besides, some of them have been identified as allergen sources or the potential mechanical vectors related to nosocomial infections. The present study aimed to assess the monthly activity, fauna, and detection of protozoan agents in phlebotomine sand flies using polymerase chain reaction (PCR) in re-emerging zoonotic cutaneous leishmaniasis foci of Shiraz and Kharameh in Fars province, southern Iran during 2016-2017. Read More

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December 2018
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Pig Movement and Antimicrobial Use Drive Transmission of Livestock-Associated Staphylococcus aureus CC398.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

The epidemiology of methicillin-resistant has changed considerably over the last 3 decades, including the recognition of lineages associated with the community and with livestock exposure, in addition to nosocomial strains. A recent study by R. N. Read More

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December 2018

Tailoring Empirical Antimicrobial Therapy in Subjects With Ventilator-Associated Pneumonia With a 10-Hour E-Test Approach.

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

Univ. de Bordeaux, UMR 5234 CNRS 'Microbiologie Cellulaire et Moléculaire et Pathogénicité'', Bordeaux, France.

Background: In a previous study of subjects suspected of having ventilator-associated pneumonia, a rapid susceptibility testing approach by using ETEST (BioMérieux) strips directly applied to bronchoalveolar lavage samples provided valuable information at hour 24. The primary objective of this study was to assess a new direct specimen testing by using an even more-rapid E-test approach (at hour 10), which could promote an early de-escalation of the antimicrobial therapy.

Methods: Twenty-eight subjects with ventilator-associated pneumonia admitted to a medical ICU were prospectively included. Read More

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December 2018

Methicillin-Resistant Staphylococcus aureus and Other Multidrug-Resistant Colonizations/Infections in an Intensive Care Unit: Predictive Factors.

Biol Res Nurs 2018 Dec 11:1099800418818387. Epub 2018 Dec 11.

2 Faculty of Nursing, Catholic University of Murcia (UCAM), Murcia, Spain.

Introduction And Objectives:: Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent pathogen causing nosocomial infections in hospitals and health centers. This work is an effort to understand the epidemiology of MRSA and other multidrug-resistant pathogens in an intensive care unit (ICU) and to analyze characteristics that might determine the risk of MRSA colonization/infection in this unit.

Method:: An observational, 1-year prospective longitudinal study was conducted to obtain information about MRSA and other multidrug-resistant colonizations/infections. Read More

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December 2018

Sex Hormones and Prolactin Levels and Their Association with Anti Cardiolipin Antibody in Patients with Systemic Lupus Erythematosus.

Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):336-345. Epub 2018 Aug 12.

Department of Internal Medicine, Lorestan University of Medical Sciences, khorramabad, Iran.

Pathogenesis of systemic lupus erythematosus (SLE) is complex and multi-factorial. Among various suggested mechanisms for the disease, the hormonal theory has been considered as one of the most important mechanisms. Recently, the association of sex hormones with manifestations of antiphospholipid antibody syndrome (APLS) has been hypothesized. Read More

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Impact of de-escalation on prognosis of patients with bacteraemia due to Enterobacteriaceae: a post-hoc analysis from a multicenter prospective cohort.

Clin Infect Dis 2018 Dec 8. Epub 2018 Dec 8.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena/Departamento de Medicina y Microbiología, Universidad de Sevilla/Instituto de Biomedicina de Sevilla (IBiS). Sevilla, Spain.

Background: More data are needed about the safety of antibiotic de-escalation in specific clinical situations as a strategy to reduce exposure to broad-spectrum antibiotics. The aims of this study were to investigate predictors of de-escalation and its impact on the outcome of patients with bloodstream infection due to Enterobacteriaceae (BSI-E).

Methods: A post-hoc analysis was performed of a prospective, multicenter cohort of patients with BSI-E initially treated with ertapenem or antipseudomonal β-lactams. Read More

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December 2018
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[Outbreak of fungemias by Sarocladium kiliense in eight public hospitals per intrinsic contamination of ondansetron intravenous].

Rev Chilena Infectol 2018 Aug;35(4):363-370

Subdepartamento de Enfermedades Infecciosas, Instituto de Salud Pública de Chile, Chile.

Sarocladium kiliense is a saprophyte fungus that can cause opportunistic infections associated to invasive procedures. We report a multi-hospital nosocomial outbreak of fungemias due to this agent. Patients with positive blood culture to this agent were studied after six bloodstream infections identified in three Chilean hospitals in July 2013 were reported to Ministry of Health National Infection and Prevention Control Program. Read More

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[Post-surgical ventriculitis due to extensively resistant Pseudomonas aeruginosa treated with intrathecal colistin. Pediatric case report and literature review].

Rev Chilena Infectol 2018 ;35(3):321-325

Universidad CES, Medellín, Colombia.

Use of Intrathecal colistin has increased in recent years and has become an alternative for the management of infections of the central nervous system caused by multidrug resistant (MDR) bacteria. Evidence of therapeutic success and safety profile is increasing, particularly in MDR Acinetobacter baumanii infections in adults. Conversely, evidence in children is limited. Read More

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January 2018

[Nosocomial urinary tract infection: an analysis beyond urinary catheterization].

Rev Chilena Infectol 2018 ;35(3):246-252

Servicio de Medicina Interna, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina.

Introduction: Nosocomially acquired urinary tract infections (NAUTI) represent an important public health issue, but its characteristics when they are not catheter associated (CA-UTI) or when they take place outside intensive care units (ICU) are poorly understood.

Objectives: To determine the patients' characteristics, etiology and antimicrobial susceptibility of NAUTI, both CA-UTI and no CA-UTI, in general ward and ICU.

Methods: We conducted a retrospective analytic cross-sectional study, between 2009 and 2013, in a third level universitary hospital. Read More

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January 2018

Draft Genome Sequence of Enterococcus faecium CL-6729, a Clinical Isolate Showing Constitutive Vancomycin Resistance.

Microbiol Resour Announc 2018 Nov 21;7(20). Epub 2018 Nov 21.

Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Here, we present the draft genome sequence of an unusual Enterococcus faecium isolate (CL-6729) showing constitutive expression of the VanA type of vancomycin resistance. The isolate was recovered from a patient with a nosocomial urinary tract infection in Brazil. Read More

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November 2018

Complete Genome Sequence of Klebsiella pneumoniae Siphophage Sugarland.

Microbiol Resour Announc 2018 Nov 15;7(19). Epub 2018 Nov 15.

Center for Phage Technology, Texas A&M University, College Station, Texas, USA.

Klebsiella pneumoniae is a Gram-negative bacterium associated with the gastrointestinal tract and is a significant nosocomial pathogen due to its antibiotic resistance. Phage therapy against K. pneumoniae may prove useful in treating infections caused by this bacterium. Read More

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November 2018

Purification, Characterization and Evaluation of Polymyxin A From : An Underexplored Member of the Polymyxin Family.

Front Microbiol 2018 23;9:2864. Epub 2018 Nov 23.

Clinical Microbiology and Bioactive Screening Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India.

Nosocomial infections caused by antibiotic-resistant Gram-negative pathogens are of grave concern today. Polymyxins are considered as the last resorts of therapy to treat these multi-drug resistant (MDR) bacteria. But their associated nephrotoxicity and neurotoxicity calls for the development of safer polymyxin therapy until novel and less toxic antibiotics are discovered. Read More

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November 2018

A multicenter epidemiology study on the risk factors and clinical outcomes of nosocomial intra-abdominal infections in China: results from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) 2007-2016.

Infect Drug Resist 2018 15;11:2311-2319. Epub 2018 Nov 15.

Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China,

Objective: This study aimed to determine the risk factors for intra-abdominal infections (IAIs), assess the clinical outcomes of IAIs, and investigate the spectrum and antimicrobial resistance of major pathogens causing IAIs.

Patients And Methods: This prospective observational study enrolled patients from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) program between 2007 and 2016. Data on the clinicopathological factors and causative pathogens were collected. Read More

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November 2018

biofilms: effects of physicochemical factors, virulence, antibiotic resistance determinants, gene regulation, and future antimicrobial treatments.

Infect Drug Resist 2018 15;11:2277-2299. Epub 2018 Nov 15.

Virology and Microbiology Research Group, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa,

is a leading cause of nosocomial infections due to its increased antibiotic resistance and virulence. The ability of to form biofilms contributes to its survival in adverse environmental conditions including hospital environments and medical devices. has undoubtedly propelled the interest of biomedical researchers due to its broad range of associated infections especially in hospital intensive care units. Read More

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November 2018

Molecular detection of and genes among vancomycin-resistant enterococci in ICU-hospitalized patients in Ahvaz in southwest of Iran.

Infect Drug Resist 2018 15;11:2269-2275. Epub 2018 Nov 15.

School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Nosocomial infections due to vancomycin-resistant enterococci (VRE) are known as a source of spreading these bacteria. The aim of this prospective study was molecular detection of and genes among VRE isolated from patients admitted to intensive care units (ICUs) in Ahvaz in southwest of Iran.

Materials And Methods: Overall, 243 non-duplicate rectal swab specimens were collected from ICU-hospitalized patients in teaching hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences, Iran. Read More

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November 2018

Antibacterial effect of ozonated water against methicillin-resistant contaminating chicken meat in Wasit Province, Iraq.

Authors:
Manal H G Kanaan

Vet World 2018 Nov 18;11(10):1445-1453. Epub 2018 Oct 18.

Department of Nursing, Technical Institute of Suwaria, Middle Technical University, Baghdad, Iraq.

Background And Aim: Methicillin-resistant (MRSA) is one of the most recognized "superbugs" and a common cause of community-associated and nosocomial infections; furthermore, when chicken meat is considered a good growth medium for to make a plausible vehicle to propagate MRSA, then this study was conducted to evaluate the efficiency of ozonated water (0.5 ppm) in the elimination or reduction of MRSA contaminating fresh and frozen chicken meat sold in local markets in the Wasit Province.

Materials And Methods: A total of 72 samples of fresh and frozen chicken meat were randomly collected from dissimilar native markets: Fresh chicken meat (n=32) and frozen chicken meat (n=40). Read More

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November 2018

Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota.

Nat Commun 2018 12 7;9(1):5233. Epub 2018 Dec 7.

Molecular Medicine, Hospital for Sick Children, 686 Bay St., Toronto, ON, M5G 0A4, Canada.

Clostridium difficile is the leading cause of nosocomial diarrhea and colitis in the industrialized world. Disruption of the protective gut microbiota by antibiotics enables colonization by multidrug-resistant C. difficile, which secrete up to three different protein toxins that are responsible for the gastrointestinal sequelae. Read More

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December 2018

[Results of a single-centre study of open and endovascular operations of prosthetic repair of abdominal aortic aneurysms].

Angiol Sosud Khir 2018 ;24(4):126-130

National Medical Research Centre named after V.A. Almazov under the RF Ministry of Public Health, Saint Petersburg, Russia.

Objective: The purpose of the study was to assess surgical outcomes in patients suffering from an infrarenal abdominal aortic aneurysm and treated at the Department of Cardiovascular Surgery #2 of the National Medical Research Centre named after V.A. Almazov. Read More

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January 2018

Impact of participation in a surgical site infection surveillance network: results from a large international cohort study.

J Hosp Infect 2018 Dec 7. Epub 2018 Dec 7.

Infection Control Programme and WHO Collaborating Centre on Patient Safety, The University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.

Introduction: Surveillance of surgical site infections (SSI) is a core component of effective infection control practices, though its impact has not been quantified on a large scale. This study aims to determine the time-trend of SSI rates in surveillance networks.

Methods: SSI surveillance networks provided procedure-specific data on numbers of SSIs and operations, stratified by hospitals' year of participation in the surveillance, to capture length of participation as an exposure. Read More

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December 2018
2.544 Impact Factor

Exploring Morin as an anti-quorum sensing agent (anti-QSA) against resistant strains of Staphylococcus aureus.

Microb Pathog 2018 Dec 7. Epub 2018 Dec 7.

PG and Research Department of Botany, Arignar Anna Government College, Thiruvalluvar University, Villupuram, Tamilnadu, India. Electronic address:

Staphylococcus aureus an opportunistic pathogen, causes biofilm-associated infections like nosocomial and chronic disease, where quorum sensing plays vital role. Biofilm-associated infections are provocative due to antibiotic resistance and become major public health threat to human. Accordingly, there is an urgent need to identify novel compounds and groundbreaking methods to pervade and clear biofilm-associated infections. Read More

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December 2018

Prospective investigation of carbapenem-resistant Klebsiella pneumonia transmission among the staff, environment, and patients in five major intensive care units, Beijing.

J Hosp Infect 2018 Dec 6. Epub 2018 Dec 6.

Department of Nosocomial Infection Management and Disease Control, Chinese PLA General Hospital, Beijing, China. Electronic address:

Background: Following the alarming outbreak of carbapenem-resistant Klebsiella pneumonia (CRKP) in five intensive care units (ICUs) of a tertiary care hospital in China, a prospective investigation of CRKP colonized/infected patients was conducted.

Aim: To describe the diffusion and transmission of CRKP among epidemiologically linked ICU patients, staff and environment.

Methods: Enhanced CRKP infected/colonized case monitoring was performed by the real-time nosocomial infection surveillance system (RT-NISS). Read More

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December 2018

Multiplex real-time PCR assays to detect Stenotrophomonas maltophilia carrying sul1, sul2, and sul3 genes.

J Microbiol Methods 2018 Dec 5;156:52-59. Epub 2018 Dec 5.

Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Nosocomial infections caused by Stenotrophomonas maltophilia resistant to SXT are increasingly reported worldwide. In this study, a novel melting-curve based multiplex real-time PCR assay for the simultaneous detection of the ssrA and sul1, sul2 and sul3 genes was first established. The assays were performed on a Roche LightCycler® 480 II system. Read More

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December 2018

Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit.

Int J Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

Infectious Disease Department, St Louis Hospital, APHP and University Paris Diderot, Paris, France.

Background: Multidrug-Resistant Acinetobacter baumannii (MR-AB) can cause outbreaks in burn units. We aimed to study the incidence, risk factors and outcome of MR-AB infections in a burn unit (BU).

Methods: A prospective study was conducted from April to November, 2014 during an outbreak in a BU in Paris. Read More

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December 2018
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The effect of mupirocin dressings on postoperative surgical site infections in elective colorectal surgery: A prospective, randomized controlled trial.

Am J Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of General Surgery, Gundersen Health System, La Crosse, WI, USA. Electronic address:

Background: Surgical site infections (SSIs) are the most common nosocomial infection among surgical patients. We hypothesized that mupirocin ointment would decrease SSI rates compared to standard surgical dressings in patients undergoing colorectal surgery.

Methods: A prospective randomized controlled trial was performed, including patients undergoing elective open and minimally invasive colorectal surgery. Read More

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November 2018

Technological innovations in infection control: A rapid review of the acceptance of behavior monitoring systems and their contribution to the improvement of hand hygiene.

Am J Infect Control 2018 Dec 5. Epub 2018 Dec 5.

Institute of Nursing Science, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Hand hygiene is crucial for preventing nosocomial infections; however, adherence rates need further attention. Prevention of nosocomial infections through regular hand hygiene monitoring and feedback is recommended by the World Health Organization. Technology holds the potential for achieving this goal. Read More

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December 2018

Evaluation of the automated BD Phoenix CPO Detect panel in combination with the β-CARBA assay for detection and classification of carbapenemase-producing Enterobacterales.

J Microbiol Methods 2018 Dec 3;156:29-33. Epub 2018 Dec 3.

Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, Franz-Josef-Strauß-Allee 11, D-93053 Regensburg, Germany.

Recently, the CPO Detect panel for the detection of carbapenemase-producing, Gram-negative bacteria was introduced for the Phoenix semi-automated antimicrobial susceptibility testing system. The CPO Detect assay aims to detect carbapenemase activity (P/N test) and to type carbapenemase producers according to the Ambler classification (Ambler test). The P/N test-based detection of carbapenemase producers was 100% sensitive and 55. Read More

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December 2018
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Bezlotoxumab use as adjunctive therapy with the third fecal microbiota transplant in refractory recurrent Clostridium difficile colitis; a case report and concise literature review.

Anaerobe 2018 Dec 3;55:112-116. Epub 2018 Dec 3.

Pulmonary Department, Physician Building, 7301 Rogers Ave, Fort Smith, AR 72903, United States.

Clostridium difficile is the most commonly reported pathogen to cause nosocomial infections in the United States with a high burden affecting morbidity, mortality and healthcare expenditure. The use of Fecal Microbiota Transplantation (FMT) is one of the current standard therapies for recurrent C. difficile infection (CDIr). Read More

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December 2018
3 Reads

Orchestration of Tryptophan-Kynurenine pathway, acute decompensation and acute-on-chronic liver failure in cirrhosis.

Hepatology 2018 Dec 6. Epub 2018 Dec 6.

EF Clif, EASL-CLIF Consortium and Grifols Chair, Barcelona, Spain.

Systemic inflammation (SI) is involved in the pathogenesis of acute decompensation (AD) and acute-on-chronic liver failure (ACLF) in cirrhosis. In other diseases, SI activates tryptophan (Trp) degradation via the kynurenine pathway (KP), giving rise to metabolites that contribute to multiorgan/system damage and immunosuppression. In the current study, we aimed to characterize the KP in patients with cirrhosis, in whom this pathway is poorly known. Read More

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December 2018
12 Reads

Managing Acinetobacter baumannii infections.

Curr Opin Infect Dis 2018 Dec 4. Epub 2018 Dec 4.

Medical and infectious diseases ICU (MI2) APHP Bichat University Hospital.

Purpose Of Review: We reviewed recent data about epidemiology of Acinetobacter baumannii, resistance mechanisms, and therapeutic options for severe infections caused by multidrug-resistant strains.

Recent Findings: A. baumannii is a major cause of nosocomial infections affecting mainly to debilitating patients in the ICU, although the spread to regular wards and to long-term care facilities is increasing. Read More

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December 2018
2 Reads

Costs of outpatient and inpatient MRSA screening and treatment strategies for patients at elective hospital admission - a decision tree analysis.

Antimicrob Resist Infect Control 2018 29;7:147. Epub 2018 Nov 29.

2Institute of Hygiene and Environmental Health, University Medicine of Greifswald, Walther-Rathenau-Straße 49a, 17489 Greifswald, Germany.

Background: Nosocomial infections are among the most common complications in hospitals. A major part is caused by multidrug-resistant organisms (MDRO). MRSA is still the most prominent and frequent MDRO. Read More

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November 2018
1 Read

First reported nosocomial outbreak of harboring and in a neonatal intensive care unit in Cairo, Egypt.

Infect Drug Resist 2018 8;11:2211-2217. Epub 2018 Nov 8.

Department of Microbiology, Faculty of Dentistry and Oral Medicine, Future University, Cairo, Egypt.

Introduction: is a significant hospital-acquired pathogen, and many outbreaks of infection have been reported in neonates. We report a sudden breakout of harboring the and metallo-β-lactamase (MBL) genes that occurred from March to August 2015 in the neonatal intensive care unit of Cairo University Hospital, Cairo, Egypt.

Methods: During the study period, 40 nonduplicate clinical isolates of were collected from blood culture samples. Read More

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November 2018
2 Reads