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Toxicol Pathol 2022 Jun 29:1926233221107607. Epub 2022 Jun 29.

Center for Health and the Environment, University of California, Davis, Davis, California, USA.

Engineered silver nanoparticles (AgNPs), including silver silicate nanoparticles (Ag-SiO NPs), are used in a wide variety of medical and consumer applications. Inhaled AgNPs have been found to translocate to the olfactory bulb (OB) after inhalation and intranasal instillation. However, the biological effects of Ag-SiO NPs and their potential nose-to-brain transport have not been evaluated. Read More

Wien Med Wochenschr 2022 Jun 27. Epub 2022 Jun 27.

Department of Anaesthesiology and Intensive Care Unit, Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina.

Background: Adenotonsillectomy is the most commonly performed surgery in the pediatric population. Hemorrhage after adenotonsillectomy, which can occur at any time postoperatively, is one of the most serious complications.

Objective: To determine the frequency of hemorrhage in children after adenotonsillectomy and to compare postoperative hemorrhage with regard to age and sex. Read More

J Immunol Res 2022 14;2022:7783481. Epub 2022 Jun 14.

Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai 200031, China.

To identify the effect of long noncoding RNA (lncRNA) FR215775 in regulating CD4+ T cells on murine models of allergic rhinitis (AR), the expression of lncRNA FR215775 in primary Th2 cells was detected through qRT-PCR. After knocking down the expression of lncRNA FR215775 via Sh-FR215775-Ads, Cell Counting Kit-8, cytometric bead array, and fluorescence-activated cell sorting were performed to determine its functions in vitro. Moreover, lncRNA FR215775-silencing or nonsilencing cells were injected intravenously into AR mice. Read More

Int J Environ Res Public Health 2022 Jun 14;19(12). Epub 2022 Jun 14.

Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, Japan.

The present study aimed to evaluate the correlation between frontal sinus morphology and craniofacial morphology, and to investigate the effects of orthodontic treatment on the development of the frontal sinus in female adolescents (mean age: 13.9 ± 1.3 years). Read More

Int J Environ Res Public Health 2022 Jun 14;19(12). Epub 2022 Jun 14.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Ostrava, 708 52 Ostrava, Czech Republic.

Although extensive research has shown the pathological effect of fine and ultrafine airborne particles, clear evidence of association of environmental exposure to them and inflammatory changes in human nasal mucosa is missing. Meanwhile, pathogenesis of chronic rhinosinusitis, despite being a disease with high prevalence in the population, is still unclear. The increasing evidence of the pro-inflammatory properties of these particles raises the question of their possible role in chronic rhinosinusitis. Read More

Adv Gerontol 2022 ;35(2):308-314

I.P.Pavlov First Saint-Petersburg State Medical University, 6-8 L. Tolstoy str., St. Petersburg 197022, Russian Federation, e-mail:

Population aging, increasing in duration of active life dictate to keep the level of health and create conditions for prolongation and preservation of ability to work. An otorhinolaryngologist often has to deal with age-related changes occurring in the nasal cavity and paranasal sinuses. The study of age-related features occurring in the nasal cavity and paranasal sinuses at the level of not only function, but also structures providing maintenance of mucous membrane protective mechanisms, preserving nasal architectonics, becomes a topical issue. Read More

J Craniofac Surg 2022 May 12;33(3):e320-e322. Epub 2021 Oct 12.

Department of Oncological and Reconstructive Surgery, Maria- Sklodowska Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.

Abstract: Composite full-thickness nasal defects that include adjacent facial units still remain a challenge for reconstructive surgeons. The commonly used auricular free flap (AFF) might not be sufficient for full coverage of a defect, and radial forearm free flap (RFFF) lacks the rigid component for nasal framework. Therefore, the authors present a chimeric flap combined of both AFF and RFFF for the reconstruction of extended nasal defects. Read More

Ultrasound Obstet Gynecol 2022 Jun 21. Epub 2022 Jun 21.

Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom.

Objective: Despite decades of obstetric scanning, the study of sonographer workflow remains largely unexplored. In the second trimester for example, sonographers use scan guidelines to guide their acquisition of standard planes and structures; however, the scan acquisition order is not prescribed. Using deep learning-based video analysis, the aim of this study was to develop a deeper understanding of the clinical workflow sonographers undertake during second-trimester anomaly scans. Read More

J Plast Reconstr Aesthet Surg 2022 Apr 28. Epub 2022 Apr 28.

The Division of Plastic and Reconstructive Surgery, Department of Surgery, Montefiore Medical Center, 1776 Eastchester Road, Suite 200, Second Floor, Bronx, NY 10461, United States. Electronic address:

Background: Recently, there has been increasing focus on understanding nasal anatomy in ethnic populations and using it to guide rhinoplasty techniques in non-Caucasian patients. Many disparate groups have historically been inappropriately clustered based on geography. However, there has been little attention on describing regional differences within these populations. Read More

Sci Rep 2022 Jun 20;12(1):10376. Epub 2022 Jun 20.

Department of Otolaryngology, Medical University of Gdansk, Gdansk, Poland.

The maxillary sinus aeration using the computational fluid dynamics (CFD) method based on individual adult patients' computed tomography (CT) scans were analyzed. The analysis was based on CT images of 4 patients: one with normal nose anatomy and three with nasal septal deviation (NSD) and concha bullosa (CB). The CFD simulation was performed using the Reynolds-Average Simulation approach and turbulence closure based on linear eddy viscosity supplemented with the two-equation k-[Formula: see text] SST model. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):746-748

Department of Otorhinolaryngology Head and Neck Surgery, the Second Hospital of Jilin University, Changchun 130041, China.

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):718-723

Department of Otolaryngology, Guangdong Province Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, China.

To investigate the method and efficacy of reconstruction of facial skin defects after removing the lesions by applying the V-Y subcutaneous pedicle flap. A retrospective analysis was performed on 23 patients with facial reconstruction by using V-Y subcutaneous pedicle flap in the Otolaryngology Department of Guangdong Integrated Traditional Chinese and Western Medicine Hospital from March 2012 to April 2021. Patient ages ranged from 45 to 85 years old, with a mean age of 66. Read More

Adv Skin Wound Care 2022 Jul;35(7):375-380

Julián Barrera-Llaurador, MD, is Dermatology Assistant Professor, Department of Dermatology, University of Puerto Rico School of Medicine, San Juan. Osward Y. Carrasquillo, MD, MPH, is Mohs Micrographic Surgery Fellow, Department of Dermatology, University of North Carolina, Chapel Hill. Marely Santiago-Vázquez, MD, is Dermatology Resident, Department of Dermatology, University of Puerto Rico School of Medicine. Valeria J. González-Molina, MD, is Clinical Fellow, Department of Dermatology, HCA Corpus Christi Medical Center-Bay Area, Texas. Sheila M. Valentín-Nogueras, MD, is Mohs Micrographic Surgeon, Director of Dermatologic Surgery, Department of Dermatology, University of Puerto Rico School of Medicine. The authors have disclosed no financial relationships related to this article. Submitted August 18, 2021; accepted in revised form January 10, 2022.

Objective: To describe the trends in second-intention healing (SIH) use at a single Mohs micrographic surgery (MMS) dermatology clinic and assess outcomes and patient satisfaction.

Methods: The authors conducted a single-center, retrospective study of patients who underwent MMS from November 2012 through November 2018. Data obtained for each patient included sex, age, tumor characteristics, number of MMS stages, final defect size, and postoperative complications. Read More

Sleep Breath 2022 Jun 16. Epub 2022 Jun 16.

Young-Otolaryngologists of the International Federations of Otorhino-Laryngological Societies (YO-IFOS), Paris, France.

Background: This international study aimed at determining current routine palate surgeries and surgical methods adopted by otolaryngologists who practice surgical management of obstructive sleep apnea (OSA).

Methods: An international online survey was developed with the collaboration of the YO-IFOS (Young Otolaryngologists-International Federation of Otorhinolaryngological Societies) to assess the current routines in palatal procedures. The surgeons were asked 33 multiple-choice questions. Read More

BMC Geriatr 2022 Jun 14;22(1):503. Epub 2022 Jun 14.

Department of Maxillofacial and Oral Surgery, Faculty of Medicine, University of Ljubljana, Hrvatski trg 6, 1000, Ljubljana, Slovenia.

Background: Facial ageing is a result of superficial wrinkling combined with changes to the underlying soft tissues and skeleton. The influence of tooth loss, as a geriatric characteristic, on facial appearance is still poorly explained. The aim was to evaluate the facial characteristics of older adults, correlate these characteristics with the dentition and make comparisons with young adults using a non-invasive 3D methodology. Read More

BMC Surg 2022 Jun 13;22(1):227. Epub 2022 Jun 13.

Department of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, # 79Qingchun Road, Zhejiang, 310003, Hangzhou, People's Republic of China.

Background: Supernumerary Nostril, also called triple nostrils or accessory nostril, is a rare congenital nasal malformation.

Case Presentation: We report one conceal case of supernumerary nostril in a 19-years-old men which is misdiagnosed to a simple small nasal skin pit. Ordinary surgical excision led to recurrent infection of the lesion postoperatively, and was eventually required secondary surgery and the lesion was finally confirmed by pathological biopsy as a trinasal nostrils. Read More

Prog Orthod 2022 Jun 13;23(1):22. Epub 2022 Jun 13.

Department of General Surgery and Medical-Surgical Specialties, School of Dentistry, Unit of Orthodontics, University of Catania, Policlinico Universitario "Gaspare Rodolico - San Marco", Via Santa Sofia 78, 95123, Catania, Italy.

Background: Several semi-automatic software are available for the three-dimensional reconstruction of the airway from DICOM files. The aim of this study was to evaluate the accuracy of the segmentation of the upper airway testing four free source and one commercially available semi-automatic software. A total of 20 cone-beam computed tomography (CBCT) were selected to perform semi-automatic segmentation of the upper airway. Read More

Front Immunol 2022 24;13:899932. Epub 2022 May 24.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.

Background: Advanced recurrent nasopharyngeal carcinoma (NPC) is a relatively common nasopharyngeal skull base disease for which there is no uniform treatment modality. Not all patients are satisfied with the efficacy of immunotherapy with or without chemotherapy.

Methods: This study included patients who underwent salvage endoscopic skull base nasopharyngectomy after immunotherapy between February 2017 and June 2021. Read More

J Int Med Res 2022 Jun;50(6):3000605221104185

Department of Oral and Maxillofacial Surgery, Matsue City Hospital, Shimane 690-8509, Japan.

A cholesterol granuloma (CG) is characterized by the presence of cholesterol crystals that cause a chronic granulomatous reaction in an enclosed space. It occurs most commonly in the head and neck region, particularly in the middle ear. Although CGs in the maxilla have also been reported, odontogenic cysts in conjunction with CGs in the maxilla are very rare. Read More

Aesthetic Plast Surg 2022 Jun 9. Epub 2022 Jun 9.

The Second School of Clinical Medicine, Southern Medical University, 253 Industry Avenue, Guangzhou City, Guangdong Province, People's Republic of China.

Background: A filler injection in the nose can be essential but is also dangerous, especially in the nasal cartilage region. To safely and accurately perform a filler injection, surgeons must have detailed knowledge of nasal anatomy.

Objectives: Associated the vessel branches and the characteristics of different nasal regions to provide suggestions for more suitable injection sites. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):488-493

Department of Pathology, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 100730, China.

To study clinicopathological features and differential diagnosis of IgG4-related diseases (IgG4-RD) in nasal cavity and paranasal sinuses. A retrospective analysis was performed in patients presenting initially with rhinosinusitis or a nasal mass, who also underwent nasal mucosa biopsy in Beijing Tongren Hospital Affiliated to Capital Medical University, from March 2016 to March 2021. According to the latest international classification diagnostic criteria of IgG4-RD published by the American Society of Rheumatology (ACR)/European Association for Rheumatology (EULAR) in 2019, 10 cases of nasal cavity and paranasal sinuses IgG4-RD were diagnosed and included in the study. Read More

BMJ Case Rep 2022 Jun 7;15(6). Epub 2022 Jun 7.

Department of Otolaryngology, Head and Neck Surgery, Cantonal Hospital Graubunden, Chur, Switzerland.

Primary Burkitt lymphoma of the thyroid is an extremely rare entity with only a few reported cases. A female patient in her 70s with Hashimoto's thyroiditis presented with a 2-month history of progressive left-sided neck swelling. Ultrasound examination revealed a multinodular goitre and fine needle aspiration (FNA) showed no signs of malignancy. Read More

No Shinkei Geka 2022 May;50(3):634-643

Department of Neurosurgery, Hôpital Lariboisière.

The extended endoscopic endonasal approach(EEA)has been expanding in recent years with the development of instruments and surgical techniques. Basically, sela, extradural, and intranasal lesions such as pituitary tumor, craniopharyngioma, chordoma, chondrosarcoma, and cholesterol granuloma are indicated. Intradural lesions or lesions that extend laterally or downward to the craniocervical junction are more difficult to operate. Read More

No Shinkei Geka 2022 May;50(3):535-543

Department of Otolaryngology-Head and Neck Surgery, Nagoya City University, Graduate School of Medical Sciences.

Endoscopic endonasal skull base surgery has become popular due to its minimally invasive nature to the patient and the development of various medical devices. The reason why it is considered less invasive is that it is possible to reach the anterior skull base lesion using the corridor of the nasal cavity and paranasal sinuses. The roles of the nasal sinuses include acting as breathing pathways, warming, humidifying, and filtering of inhaled air, olfaction, and being a resonant cavity, all of which are important for a comfortable life, and the loss of these functions reduces the quality of life. Read More

Comput Biol Med 2022 May 31;147:105676. Epub 2022 May 31.

Mechanical & Automotive Engineering, School of Engineering, RMIT University, VIC, Australia. Electronic address:

Air conditioning in the nasal airways plays an important role in regulating ambient atmospheric temperature and humidity conditions of the inhaled air. Inevitably, it may alter the behaviour and fate of inhaled ambient aerosols within the human respiratory airways due to hygroscopic growth and droplet evaporation, which is a phenomena of variations in particle sizes due to physical and chemical reactions on particle surfaces in different temperature and humidity fields. Although laboratory animals have been widely used to predict health effects of human exposure to ambient substances, the nasal temperature and humidity responses in animal surrogates and human nasal cavities are still less-investigated. Read More

STAR Protoc 2022 06 27;3(2):101419. Epub 2022 May 27.

Service de Pneumologie et Allergologie Pédiatriques, Centre de Ressourcés et de Compétence de la Mucoviscidose, Hôpital Necker Enfants Malades, 149 rue de Sévres, Paris, France.

Here, we present a standardized protocol for isolation, maintenance, and polarization of the respiratory epithelial primary cells from patient samples acquired from nasal brushing, polyp specimens, or lung explants. This protocol generates a clearly defined polarized layer of epithelial cells on filters, with a good number of ciliated cells and a thin layer of mucus. We detail the steps for samples prepared from patients with cystic fibrosis as well as from subjects without cystic fibrosis. Read More

Int J Surg Case Rep 2022 Jun 18;95:107225. Epub 2022 May 18.

University of Sassari, Department of Medical, Surgical and Experimental Sciences, Sassari University Hospital Trust, Plastic Surgery Unit, Sassari, Italy; University of Sassari, School of Specialization in Plastic, Reconstructive and Aesthetic Surgery. Electronic address:

Introduction And Importance: Basal cell carcinomas represent the most frequent skin cancer and the nose is the most common site of presentation. This has an impact on both aesthetics and function of the nose and consequences in patients' psyche.

Case Presentation: In our paper, the first case in literature of a cutaneous fistula in the nasal soft triangle, after a basal cell carcinoma excision, and its reconstruction, is reported. Read More

Oral Oncol 2022 Jul 2;130:105945. Epub 2022 Jun 2.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address:

Adenoid cystic carcinoma (ACC) is a rare malignant tumor derived mainly from the salivary glands, representing approximately 1% of all headandneck carcinomasand 10% of all salivary gland neoplasms. ACC displays a paradoxical behavioral combination of an indolent growth pattern but an aggressive progression, with local recurrence and distant metastasis. The propensity of ACC of the head and neck (ACCHN) for perineural invasion and its anatomical location, especially if it extends to the nasal cavity and paranasal sinuses, facilitates tumor involvement in the surrounding structures, such as the orbit, pterygopalatine fossa, Meckel'scave, and cavernous sinus, which can lead to skull base involvement and intracranial extension. Read More

J UOEH 2022 ;44(2):215-219

Department of Dermatology, University of Occupational and Environmental Health, Japan.

A 73-year-old male noticed a localized nose erosion that we thought was possibly an exacerbation of skin erosion due to the direct influence of friction from wearing a mask. Blood examination revealed a remarkable increase in serum anti-desmoglein-1 and anti-desmoglein-3 antibodies. A skin biopsy showed acantholysis in the epidermal granular layer. Read More

J Hematol Oncol 2022 Jun 3;15(1):74. Epub 2022 Jun 3.

Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China.

Natural killer (NK)/T-cell lymphomas are aggressive malignancies with a predilection for Asian and South American populations. Epstein-Barr virus (EBV) infection in lymphoma cells is universal. Predominantly extranodal, NK/T-cell lymphomas are divided clinically into nasal (involving the nose and upper aerodigestive tract), non-nasal (involving the skin, gastrointestinal tract, testes, and other organs), and aggressive leukaemia/lymphoma (involving the marrow and multiple organs) subtypes. Read More