1,884 results match your criteria Norwalk Virus


The relationship between trunk position sense and postural control in ataxic individuals.

Gait Posture 2018 Dec 6;68:258-263. Epub 2018 Dec 6.

Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.

Background: The proprioceptive system plays a role in the maintenance of postural control more than the visual and vestibular systems in ataxic patients with postural control disorders, but the relationship between trunk proprioception and postural control has not been sufficiently investigated yet. This relationship can provide a different perspective to the ataxia rehabilitation.

Research Question: This study aimed to examine the relationship between trunk position sense and postural control in ataxic individuals by comparing them to healthy individuals. Read More

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December 2018

What makes a group fitness program for people with Parkinson's disease endure? A mixed-methods study of multiple stakeholders.

Complement Ther Med 2018 Dec 31;41:320-327. Epub 2018 Aug 31.

Long Island University Brooklyn, School of Health Professions, United States.

Objective: Identify key features of an enduring group exercise program for people with Parkinson's disease (PD) by exploring experiences of participants, student assistants and the exercise instructor through a convergent mixed methods design.

Methods: Fourteen people with PD (modified Hoehn & Yahr: 1-3.5) who regularly participated in a group exercise program (≥ 50% of classes for ≥ 1 year) were interviewed to explore their perceptions of the program. Read More

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December 2018
2 Reads

Dental Emergencies.

Emerg Med Clin North Am 2019 Feb;37(1):81-93

Department of Emergency Medicine, Norwalk Hospital, 34 Maple Street, Norwalk, CT 06850, USA.

Dental emergencies present frequently to the emergency department and urgent care centers. Trauma to the teeth includes fractures, luxations, and avulsions, which can be reduced in most cases. Avulsed primary teeth should never be replaced. Read More

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February 2019
3 Reads

Good Citizenship Made Easy: A Step-by-Step Guide to Submitting RNA-Seq Data to NCBI.

Curr Protoc Bioinformatics 2018 Dec 13;64(1):e67. Epub 2018 Nov 13.

Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York.

The analysis of transcriptome data from non-model organisms contributes to our understanding of diverse aspects of evolutionary biology, including developmental processes, speciation, adaptation, and extinction. Underlying this diversity is one shared feature, the generation of enormous amounts of sequence data. Data availability requirements in most journals oblige researchers to make their raw transcriptome data publicly available, and the databases housed at the National Center for Biotechnology Information (NCBI) are a popular choice for data deposition. Read More

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December 2018
6 Reads

A Randomized Controlled Trial of TELEmedicine for Patients with Inflammatory Bowel Disease (TELE-IBD).

Am J Gastroenterol 2018 Nov 8. Epub 2018 Nov 8.

University of Maryland School of Medicine, Department of Epidemiology and Public Health, Baltimore, MD, USA.

Introduction: Telemedicine has shown promise in inflammatory bowel disease (IBD). The objective of this study was to compare disease activity and quality of life (QoL) in a 1 year randomized trial of IBD patients receiving telemedicine versus standard care.

Methods: Patients with worsening symptoms in the prior 2 years were eligible for randomization to telemedicine (monitoring via texts EOW or weekly) or standard care. Read More

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November 2018
9 Reads

When Further Pharmacotherapy Seems Futile.

J Clin Psychiatry 2018 Oct 30;80(1). Epub 2018 Oct 30.

128 East Ave, Norwalk, CT 06851.

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October 2018
1 Read

Genetic Predisposition to Infectious Disease.

Authors:
Nikolai Klebanov

Cureus 2018 Aug 27;10(8):e3210. Epub 2018 Aug 27.

Dermatology, Massachusetts General Hospital, Boston, USA.

In contemporary medical practice, approaches to infectious disease management have been primarily rooted in a pathogen-centered model. However, host genetics also contribute significantly to infectious disease burden. The fast expansion of bioinformatics techniques and the popularization of the genome-wide association study (GWAS) in recent decades have allowed for rapid and affordable high-throughput genomic analyses. Read More

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August 2018
7 Reads

Geographically representative scholarship and internationalization in school and educational psychology: A bibliometric analysis of eight journals from 2002-2016.

J Sch Psychol 2018 Oct 8;70:44-63. Epub 2018 Aug 8.

Universidad San Francisco de Quito, Ecuador.

Although the discipline of school and educational psychology is arguably international (e.g., relevant research and practice is evident in more than 80 countries), there has been limited research examining the international scholarship published in school and educational psychology journals. Read More

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October 2018

Investigation of the viral and bacterial microbiota in intestinal samples from mink (Neovison vison) with pre-weaning diarrhea syndrome using next generation sequencing.

PLoS One 2018 18;13(10):e0205890. Epub 2018 Oct 18.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark.

Pre-weaning diarrhea (PWD) in mink kits is a common multifactorial syndrome on commercial mink farms. Several potential pathogens such as astroviruses, caliciviruses, Escherichia coli and Staphylococcus delphini have been studied, but the etiology of the syndrome seems complex. In pooled samples from 38 diarrheic and 42 non-diarrheic litters, each comprising of intestinal contents from 2-3 mink kits from the same litter, the bacterial populations were studied using Illumina Next Generation Sequencing technology and targeted 16S amplicon sequencing. Read More

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October 2018
4 Reads

The Effect of the Cartridge Used in Laparoscopic Sleeve Gastrectomy on the Development of a Staple-Line Leak.

Am Surg 2018 Sep;84(9):1499-1503

Morbid obesity surgery has increased by 450 per cent in the past decade. Preferred surgical techniques have also changed, and since 2014, the most common surgical procedure worldwide has been laparoscopic sleeve gastrectomy (LSG). The most serious complication of this surgery is staple-line leaks, which leads to significant increases in cost and a considerable rate of mortality. Read More

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September 2018
12 Reads

Eligibility of Feline Calicivirus for a Surrogate of Human Norovirus in Comparison with Murine Norovirus, Poliovirus and Coxsackievirus.

Biocontrol Sci 2018 ;23(3):145-149

Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University.

Feline calicivirus (FCV) is frequently used as a surrogate of human norovirus. We investigated eligibility of FCV for anti-viral assay by investigating the stability of infectivity and pH sensitivity in comparison with other viruses. We found that infectivities of FCV and murine norovirus (MNV) are relatively unstable in infected cells compared with those of coxsackievirus (CoV) and poliovirus (PoV) , suggesting that FCV and MNV have vulnerability. Read More

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December 2018

Quito's virome: Metagenomic analysis of viral diversity in urban streams of Ecuador's capital city.

Sci Total Environ 2018 Dec 23;645:1334-1343. Epub 2018 Jul 23.

Grupo de investigación Biodiversidad, Medio Ambiente y Salud (BIOMAS), Facultad de Ingenierías y Ciencias Aplicadas (FICA), Ingeniería Ambiental, Universidad de las Américas, Quito, Ecuador. Electronic address:

In Quito, the microbiological contamination of surface water represents a public health problem, mainly due to the lack of sewage treatment from urban wastewater. Contaminated water contributes to the transmission of many enteric pathogens through direct consumption, agricultural and recreational use. Among the different pathogens present in urban discharges, viruses play an important role on disease, being causes of gastroenteritis, hepatitis, meningitis, respiratory infections, among others. Read More

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December 2018
4 Reads

African American Spirituality and Diabetes Self-Care.

Home Healthc Now 2018 Sep/Oct;36(5):324-325

Lellieth Latchman, RD, CD-N, CDE, is a Registered Dietitian, Diabetes Educator, Norwalk Hospital, Norwalk, Connecticut.

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September 2018

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis.

PLoS Genet 2018 Sep 6;14(9):e1007589. Epub 2018 Sep 6.

Integrated Cancer Genomics Division, Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America.

Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful comparative model for human melanoma, but little is known about its genetic etiology. We mapped the genomic landscape of canine melanoma through multi-platform analysis of 37 tumors (31 mucosal, 3 acral, 2 cutaneous, and 1 uveal) and 17 matching constitutional samples including long- and short-insert whole genome sequencing, RNA sequencing, array comparative genomic hybridization, single nucleotide polymorphism array, and targeted Sanger sequencing analyses. We identified novel predominantly truncating mutations in the putative tumor suppressor gene PTPRJ in 19% of cases. Read More

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September 2018
8 Reads

Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of inoperable, metastatic, or recurrent canine pheochromocytomas: 5 dogs (2014-2017).

BMC Vet Res 2018 Sep 3;14(1):272. Epub 2018 Sep 3.

VCA Clinical Studies, Los Angeles, CA, USA.

Background: Effective treatment options for inoperable, metastatic, or recurrent canine pheochromocytomas are lacking. In humans, specific germline mutations exist that drive the development of pheochromocytomas. Pharmaceutical blockade of these abnormalities with small molecule inhibitors are an effective treatment strategy. Read More

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September 2018
7 Reads

Using a Marketing Evaluation Tool to Optimize a Social Marketing Campaign: Insights From a Copy Test of a You're the Mom Campaign Ad.

J Nutr Educ Behav 2018 Oct 27;50(9):937-946.e1. Epub 2018 Aug 27.

ChildObesity180, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.

A copy test is a business tool for assessing advertisements. This report provides an example of how copy test may be used within nutrition education practice and research. A public health nutrition advertisement for You're the Mom was copy tested with a market research firm. Read More

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October 2018
7 Reads

Antiviral activity of Schizonepeta tenuifolia Briquet against noroviruses via induction of antiviral interferons.

J Microbiol 2018 Sep 23;56(9):683-689. Epub 2018 Aug 23.

Virus-Host Interactions Laboratory, Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.

Human noroviruses are the causative agents of non-bacterial gastroenteritis worldwide. The rapid onset and resolution of disease symptoms suggest that innate immune responses are critical for controlling norovirus infection; however, no effective antivirals are yet available. The present study was conducted to examine the antiviral activities of Schizonepeta tenuifolia Briquet extract (STE) against noroviruses. Read More

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September 2018
5 Reads

Physiological and behavioral response of the Asian shore crab, , to salinity: implications for estuarine distribution and invasion.

PeerJ 2018 14;6:e5446. Epub 2018 Aug 14.

Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, United States of America.

The invasive Asian shore crab, , is ubiquitous in the rocky intertidal zone of the western North Atlantic. A likely contributor to this colonization is that is able to handle a wide range of salinities, and is thus more likely to spread through a greater geographic area of estuaries. This study investigated the salinity effects on this animal by observing survival across a range of salinities, the maintenance of hemolymph osmolality under different salinities, and behavioral preference for and avoidance of salinities. Read More

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August 2018
6 Reads

Updates on the Role of Imaging in Cardiac Sarcoidosis.

Curr Treat Options Cardiovasc Med 2018 Aug 7;20(9):74. Epub 2018 Aug 7.

Department of Internal Medicine, Kettering Medical Center, Dayton, OH, USA.

Purpose Of Review: The non-specific symptom profile and subclinical nature of disease along with variable region of cardiac involvement in systemic sarcoidosis make the diagnosis particularly challenging. The yield of endomyocardial biopsy, a gold standard for diagnosis, is not high unless coupled with additional imaging modalities to detect regional involvement. This review is focused on highlighting the major recent advances in imaging modalities and diagnosis of cardiac sarcoidosis. Read More

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August 2018
11 Reads

Authors' response.

Am J Orthod Dentofacial Orthop 2018 08;154(2):156-157

Norwalk, Ohio.

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August 2018
1 Read

Distribution and Establishment of the Lone Star Tick in Connecticut and Implications for Range Expansion and Public Health.

J Med Entomol 2018 Oct;55(6):1561-1568

Wildlife Division, Connecticut Department of Energy and Environmental Protection, North Franklin, CT.

In the United States, the lone star tick, Amblyomma americanum (L.) (Acari: Ixodidae), is an aggressive southeastern species whose range has reportedly been steadily expanding northward. The number of A. Read More

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October 2018

Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses.

Biomed Res Int 2018 12;2018:2739830. Epub 2018 Jun 12.

Division of Zoonosis of Natural Foci, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.

Interferons (IFNs) can inhibit most, if not all, viral infections by eliciting the transcription of hundreds of interferon-stimulated genes (ISGs). Feline calicivirus (FCV) is a highly contagious pathogen of cats and a surrogate for Norwalk virus. Interferon efficiently inhibits the replication of FCV, but the mechanism of the antiviral activity is poorly understood. Read More

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Heads or tails: confusion about "proximal" and "distal" terminology for pancreaticobiliary anatomy.

Endosc Int Open 2018 Jul 4;6(7):E801-E805. Epub 2018 Jul 4.

Center for Advanced Therapeutic Endoscopy, Department of Gastroenterology, Geisinger Medical Center, Danville, Pennsylvania, United States.

Background And Study Aims : The anatomical meaning of the terms "proximal" and "distal" in relation to the pancreaticobiliary anatomy can be confusing. We aimed to investigate practice patterns of use of the terms "proximal" and "distal" for pancreaticobiliary anatomy amongst various medical specialties.

Materials And Methods : An online survey link to a normal pancreaticobiliary diagram was emailed to a multispecialty physician pool. Read More

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July 2018
12 Reads

A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis.

Leukemia 2018 Jul 2. Epub 2018 Jul 2.

Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Patients with newly diagnosed multiple myeloma (NDMM) with high-risk disease are in need of new treatment strategies to improve the outcomes. Multiple clinical, cytogenetic, or gene expression features have been used to identify high-risk patients, each of which has significant weaknesses. Inclusion of molecular features into risk stratification could resolve the current challenges. Read More

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July 2018
21 Reads

Polypectomy versus surgery in early colon cancer: size and location of colon cancer affect long-term survival.

Int J Colorectal Dis 2018 Jun 24. Epub 2018 Jun 24.

University Hospital, Augusta, GA, 30901, USA.

Background And Aims: The colon cancer survival rate is significantly affected by location, stage, and size of the cancer. Polypectomy was shown be as equally effective as surgery in early-stage colon cancer, but there have been no established clinical guidelines in the management of colon cancer based on the size of the polyp or the tumor location. The aim of our study was to assess the early-stage colon cancer-specific survival rate in patients who underwent endoscopic polypectomy versus surgery, based on size and location of tumor in early-stage colon cancer. Read More

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June 2018
7 Reads

Restricted spectral accuracy analysis to identify the single correct organic compound elemental-composition from Orbitrap accurate mass data lists obtained at very high resolution.

J Mass Spectrom 2018 Oct 16;53(10):921-926. Epub 2018 Aug 16.

Cerno Bioscience, 40 Richards Ave., Norwalk, CT, 06854, USA.

Restricted spectral accuracy is applied to Orbitrap data (240 000 resolution at m/z 400) to more clearly break out the scoring and ranking of allowable elemental compositions (ECs) in a candidate list. The correct EC is usually top ranked and separated from other answers by 10 to 40% within the dimensionless 0 to 100% scale, providing a single, definitive EC. The A + 2 position (where A denotes the monoisotopic line position) is especially advantageous in restricted spectral accuracy. Read More

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October 2018

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.

Blood 2018 Aug 8;132(6):587-597. Epub 2018 Jun 8.

Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR.

Understanding the profile of oncogene and tumor suppressor gene mutations with their interactions and impact on the prognosis of multiple myeloma (MM) can improve the definition of disease subsets and identify pathways important in disease pathobiology. Using integrated genomics of 1273 newly diagnosed patients with MM, we identified 63 driver genes, some of which are novel, including , , , , and Oncogene mutations are significantly more clonal than tumor suppressor mutations, indicating they may exert a bigger selective pressure. Patients with more driver gene abnormalities are associated with worse outcomes, as are identified mechanisms of genomic instability. Read More

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August 2018
19 Reads

Peripheral Arterial Disease in Women: an Overview of Risk Factor Profile, Clinical Features, and Outcomes.

Curr Atheroscler Rep 2018 Jun 2;20(8):40. Epub 2018 Jun 2.

Cardiac Center, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia.

Purpose Of Review: Peripheral arterial disease (PAD) is the third most common manifestation of cardiovascular disease (CVD), following coronary artery disease (CAD) and stroke. PAD remains underdiagnosed and under-treated in women.

Recent Findings: Women with PAD experience more atypical symptoms and poorer overall health status. Read More

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June 2018
2 Reads

Development of an infectious clone and replicon system of norovirus GII.4.

J Virol Methods 2018 08 22;258:49-53. Epub 2018 May 22.

Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brazil; Pós-graduação em Biologia Molecular, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brazil. Electronic address:

Human norovirus (HuNoV) is one of the main causes of acute gastroenteritis worldwide and is responsible for at least 20% of all cases. The detailed molecular mechanism of this norovirus remains unknown due to the lack of a suitable in vitro culturing system. An infectious clone of HuNoV would be a useful tool for elucidating the processes of viral infection and the mechanisms of replication. Read More

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August 2018
3 Reads

Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection.

N Engl J Med 2018 Jul 20;379(3):236-249. Epub 2018 May 20.

From the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center (D.T.H., C.-C.H.C., J.A.K., O.M.P.-P., D.C.A.), the Departments of Critical Care Medicine (D.T.H., J.A.K., O.M.P.-P., D.C.A.), Emergency Medicine (D.T.H., D.M.Y., A.M.B., H.P.), and Pathology (O.M.P.-P.), the MACRO (Multidisciplinary Acute Care Research Organization) Center (D.T.H., D.M.Y., D.C.A.), and the Divisions of General Internal Medicine (C.-C.H.C., M.J.F., J.Y.) and Infectious Diseases (Y.D.), University of Pittsburgh, and the Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System (M.J.F.) - all in Pittsburgh; the Department of Emergency Medicine, Massachusetts General Hospital (M.R.F.), the Department of Emergency Medicine, Beth Israel Deaconess Medical Center (M.W.D.), and the Department of Emergency Medicine, Brigham and Women's Hospital (P.C.H.) - all in Boston; the Department of Emergency Medicine, Norwalk Hospital, Norwalk, CT (J.F.); the Department of Emergency Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA (M.A.F., T.T.); the Department of Emergency Medicine, Essentia Health, Duluth, MN (J.M.H.); the Department of Emergency Medicine, University of Maryland Medical Center, Baltimore (F.K.); the Department of Emergency Medicine, University of Alabama at Birmingham Hospital, Birmingham (M.C.K.); the Department of Emergency Medicine, University of California at Irvine Medical Center, Irvine (S.L.); the Department of Emergency Medicine, Maricopa Medical Center, Phoenix, AZ (F.L.); Eli Lilly, Indianapolis (F.P.); the Department of Emergency Medicine, Detroit Receiving Hospital, Detroit (R.L.S.); the Department of Emergency Medicine, Ohio State University, Columbus (L.S., T.T.); and Statistics Collaborative, Washington, DC (L.A.W.).

Background: The effect of procalcitonin-guided use of antibiotics on treatment for suspected lower respiratory tract infection is unclear.

Methods: In 14 U.S. Read More

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July 2018
6 Reads

Expression, Purification and Characterization of a GII.4 Norovirus Protease from Minerva Virus.

Infect Disord Drug Targets 2018 ;18(3):224-232

Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, United States.

Background: Noroviruses are the leading cause of acute gastroenteritis worldwide. Norovirus proteases, which are responsible for cleavage of the viral polyprotein, have become an attractive drug target to treat norovirus infections. Genogroup II (GII) noroviruses are responsible for a majority of outbreaks; however, limited data exists regarding GII norovirus proteases. Read More

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January 2018
14 Reads

Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma.

Leukemia 2018 Dec 29;32(12):2626-2635. Epub 2018 Mar 29.

Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.

Although long intergenic non-coding RNAs (lincRNA) role in various cancers is described, their significance in Multiple Myeloma (MM) remains poorly defined. Here we have studied the lincRNA profile and their clinical impact in MM. We performed RNA-seq on MM cells from 308 newly diagnosed and uniformly treated patients, 16 normal plasma cells and utilized RNA-seq data from 532 newly diagnosed patients from CoMMpass study to analyze for lincRNAs. Read More

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December 2018
6 Reads

Association of intensive care unit delirium with sleep disturbance and functional disability after critical illness: an observational cohort study.

Ann Intensive Care 2018 May 8;8(1):63. Epub 2018 May 8.

Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.

Background: In medical intensive care unit (MICU) patients, the predictors of post-discharge sleep disturbance and functional disability are poorly understood. ICU delirium is a risk factor with a plausible link to sleep disturbance and disability. This study evaluated the prevalence of self-reported post-ICU sleep disturbance and increased functional disability, and their association with MICU delirium and other ICU factors. Read More

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May 2018
1 Read

Name Norms: A Guide to Casting Your Next Experiment.

Pers Soc Psychol Bull 2018 Oct 8;44(10):1435-1448. Epub 2018 May 8.

5 Mississippi State University, Mississippi State, MS, USA.

Psychologists often test hypotheses by constructing vignettes depicting people engaging in behavior and displaying characteristics designed to operationalize specific variables. People described in these vignettes are typically given names, but names have a variety of connotations that could lead to unwanted variance between conditions of an experiment and in other ways have implications for the results of a study. An up-to-date source of information to help guide the selection of names would be useful for researchers. Read More

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October 2018
2 Reads

Head impacts and cognitive performance in men's lacrosse.

Phys Sportsmed 2018 09 7;46(3):324-330. Epub 2018 May 7.

a Exercise and Sport Performance , University of New England , Biddeford , ME , USA.

Objectives: The purpose of this investigation was to record head impacts and assess cognitive function throughout a NCAA Division III men's lacrosse season.

Methods: Fifteen NCAA Div III men's lacrosse players (age = 21.1 ± 1. Read More

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September 2018
12 Reads

Postponing Childbearing and Fertility Preservation in Young Professional Women.

South Med J 2018 04;111(4):187-191

From the Division of Reproductive Endocrinology and Infertility, Department of OB/GYN, University of Cincinnati Medical Center, Cincinnati, Ohio, Reproductive Medicine Associates of Connecticut, Norwalk, Connecticut, Christ Hospital, Cincinnati, Ohio, Colorado Center for Reproductive Medicine Minneapolis, Minneapolis, Minnesota, and the University of Buffalo, Buffalo, New York.

Objectives: To evaluate young women's awareness of ovarian reserve testing and oocyte cryopreservation (OC) and assess how testing ovarian reserve may affect the desire for fertility preservation.

Methods: Three questionnaire-based observational studies were conducted among female students/young professionals 20 years of age and older. The third survey was completed after participants were offered anti-Mullerian hormone (AMH) testing. Read More

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Evaluation of a multifunctional femtosecond laser for the creation of laser in situ keratomileusis flaps.

J Cataract Refract Surg 2018 Mar;44(3):280-286

From the Slade & Baker Vision Center (Slade), Houston, Texas, Alcon Research (Ignacio), Lake Forest, California, and Spector Eye Care (Spector), Norwalk, Connecticut, USA.

Purpose: To characterize the performance of a multifunctional femtosecond laser system (Lensx) for the creation of laser in situ keratomileusis (LASIK) flaps.

Setting: Two surgical sites in the United States.

Design: Prospective case series pilot study. Read More

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March 2018
3 Reads

Guidelines for hospital privileges in vascular surgery and endovascular interventions: Recommendations of the Society for Vascular Surgery.

J Vasc Surg 2018 05;67(5):1337-1344

Vascular Surgery, Franciscan Health, Indianapolis, Ind.

The Hospital Privileges Practice Guideline Writing Group of the Society for Vascular Surgery is making the following five recommendations concerning guidelines for hospital privileges for vascular surgery and endovascular therapy. Advanced endovascular procedures are currently entrenched in the everyday practice of specialized vascular interventionalists, including vascular surgeons, but open vascular surgery remains uniquely essential to the specialty. First, we endorse the Residency Review Committee for Surgery recommendations regarding open and endovascular cases during vascular residency and fellowship training. Read More

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May 2018
1 Read

Estimating the Asymptomatic Ratio of Norovirus Infection During Foodborne Outbreaks With Laboratory Testing in Japan.

J Epidemiol 2018 09 31;28(9):382-387. Epub 2018 Mar 31.

Graduate School of Medicine, Hokkaido University.

Background: Foodborne norovirus outbreak data in Japan from 2005-2006, involving virological surveillance of all symptomatic and asymptomatic individuals, were reanalyzed to estimate the asymptomatic ratio of norovirus infection along with the risk of infection and the probability of virus shedding.

Methods: Employing a statistical model that is considered to capture the data-generating process of the outbreak and virus surveillance, maximum likelihood estimation of the asymptomatic ratio was implemented.

Results: Assuming that all norovirus outbreaks (n = 55) were the result of random sampling from an identical distribution and ignoring genogroup and genotype specificities, the asymptomatic ratio was estimated at 32. Read More

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September 2018
2 Reads

A multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5.

Blood Cancer J 2018 Mar 21;8(3):35. Epub 2018 Mar 21.

Department of Medicine, Washington University School of Medicine, St. Louis, 63110, MO, USA.

Multiple myeloma (MM) is a disease of copy number variants (CNVs), chromosomal translocations, and single-nucleotide variants (SNVs). To enable integrative studies across these diverse mutation types, we developed a capture-based sequencing platform to detect their occurrence in 465 genes altered in MM and used it to sequence 95 primary tumor-normal pairs to a mean depth of 104×. We detected cases of hyperdiploidy (23%), deletions of 1p (8%), 6q (21%), 8p (17%), 14q (16%), 16q (22%), and 17p (4%), and amplification of 1q (19%). Read More

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March 2018
7 Reads

Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells .

Antimicrob Agents Chemother 2018 May 26;62(5). Epub 2018 Apr 26.

Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds and has thus accelerated the process of drug discovery against HuNoV infection. Rupintrivir, an irreversible inhibitor of the human rhinovirus 3C protease, has been reported to inhibit the replication of the Norwalk virus replicon via the inhibition of the norovirus protease. Read More

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May 2018
12 Reads

TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation.

Antimicrob Agents Chemother 2018 May 26;62(5). Epub 2018 Apr 26.

School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, Australia

Norovirus infections are a significant health and economic burden globally, accounting for hundreds of millions of cases of acute gastroenteritis every year. In the absence of an approved norovirus vaccine, there is an urgent need to develop antivirals to treat chronic infections and provide prophylactic therapy to limit viral spread during epidemics and pandemics. Toll-like receptor (TLR) agonists have been explored widely for their antiviral potential, and several are progressing through clinical trials for the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and as adjuvants for norovirus viruslike particle (VLP) vaccines. Read More

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May 2018
5 Reads

Obesity and the Risk of Colonic Diverticulosis: A Meta-analysis.

Dis Colon Rectum 2018 Apr;61(4):476-483

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Background: The possible relationship between obesity and the risk of colonic diverticulosis has been suggested by recent epidemiologic studies, although the results were inconsistent.

Objective: This systematic review and meta-analysis was conducted to summarize all of the available data.

Data Sources: A comprehensive literature review was conducted using the MEDLINE and EMBASE databases through January 2017. Read More

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April 2018
5 Reads
3.750 Impact Factor

HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS AFTER INTRACAMERAL VANCOMYCIN USE IN CATARACT SURGERY AFTER INTRAVENOUS EXPOSURE.

Retin Cases Brief Rep 2018 Feb 22. Epub 2018 Feb 22.

Department of Ophthalmology, Yale University, New Haven, Connecticut.

Purpose: To report a case of hemorrhagic occlusive retinal vasculitis after cataract surgery.

Methods: A 74-year-old woman presented with blurry vision and distorted vision, which started 2 days after an uncomplicated cataract surgery in the left eye. Intracameral vancomycin was injected during the case. Read More

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February 2018

Case 3: Progressive Leg Pain and Weakness in a 16-year-old Boy.

Pediatr Rev 2018 Feb;39(2):94

Department of Pediatrics, University of Vermont College of Medicine, Burlington, VT.

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February 2018
1 Read

Efficacy and safety of oxymetazoline cream 1.0% for treatment of persistent facial erythema associated with rosacea: Findings from the 52-week open label REVEAL trial.

J Am Acad Dermatol 2018 Jun 31;78(6):1156-1163. Epub 2018 Jan 31.

Allergan plc, Irvine, California.

Background: Limited treatments are available for persistent erythema of rosacea.

Objective: To examine the long-term safety and efficacy of oxymetazoline cream 1.0% in patients with rosacea with moderate-to-severe persistent erythema. Read More

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June 2018
17 Reads

Which orthodontic appliance is best for oral hygiene? A randomized clinical trial.

Am J Orthod Dentofacial Orthop 2018 Feb;153(2):175-183

Division of Orthodontics, Department of Craniofacial Sciences, University of Connecticut Health, Farmington, Conn. Electronic address:

Introduction: Clear aligners and to a lesser extent self-ligated brackets are considered to facilitate better oral hygiene than traditional fixed orthodontic appliances. This 3-arm parallel-group prospective randomized clinical trial compared the long-term and short-term effects of clear aligners, self-ligated brackets, and conventional (elastomeric-ligated) brackets on patients' oral hygiene during active orthodontic treatment.

Methods: Seventy-one participants (41 boys, 30 girls; mean age, 15. Read More

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February 2018
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Surface Chemistry and Spectroscopic Study of a Cholera Toxin B Langmuir Monolayer.

Langmuir 2018 02 5;34(7):2557-2564. Epub 2018 Feb 5.

Department of Chemistry, University of Miami , 1301 Memorial Drive, Coral Gables, Florida 33146, United States.

In this article, we explored the surface chemistry properties of a cholera toxin B (CTB) monolayer at the air-subphase interface and investigated the change in interfacial properties through in situ spectroscopy. The study showed that the impact of the blue shift was negligible, suggesting that the CTB molecules were minimally affected by the subphase molecules. The stability of the CTB monolayer was studied by maintaining the constant surface pressure for a long time and also by using the compression-decompression cycle experiments. Read More

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February 2018
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