530,012 results match your criteria North American journal of medical sciences[Journal]


Xenotransplantation: Progress Along Paths Uncertain from Models to Application.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Translational Medicine and The Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

For more than a century, transplantation of tissues and organs from animals into man, xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest in xenotransplantation was fueled especially by successful application of allotransplantation, that is, transplantation of human tissue and organs, as a treatment for a variety of diseases, especially organ failure because scarcity of human tissues limited allotransplantation to a fraction of those who could benefit. In principle, use of animals such as pigs as a source of transplants would allow transplantation to exert a vastly greater impact than allotransplantation on medicine and public health. Read More

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December 2018
2 Reads

Obese Patients Benefit, but do not Fare as Well as Nonobese Patients, Following Lumbar Spondylolisthesis Surgery: An Analysis of the Quality Outcomes Database.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurological Surgery, University of California, San Francisco, California.

Background: Given recent differing findings following 2 randomized clinical trials on degenerative lumbar spondylolisthesis (DLS) surgery, there is a need to better define how subsets of patients fare following surgery.

Objective: To investigate the impact of obesity on patient-reported outcomes (PROs) following DLS surgery.

Methods: A total of 12 high-enrolling sites were queried, and we found 797 patients undergoing surgery for grade 1 DLS. Read More

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December 2018

Household transmission of seasonal influenza from HIV-infected and -uninfected individuals in South Africa, 2013-2014.

J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.

Background: Differential transmission from HIV-infected compared to HIV-uninfected individuals may impact influenza burden. We estimated the household secondary infection risk (SIR) and serial interval (SI) for influenza transmission from HIV-infected and HIV-uninfected index cases and identified associated factors.

Methods: Index cases were the first symptomatic person in a household with influenza-like illness, testing influenza positive on real-time reverse transcription polymerase chain reaction (rRT-PCR). Read More

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December 2018

Roles of Ventromedial Prefrontal Cortex and Anterior Cingulate in Subjective Valuation of Prospective Effort.

Cereb Cortex 2018 Dec 12. Epub 2018 Dec 12.

Department of Biomedical Engineering, Johns Hopkins School of Medicine, 773 North Broadway, Baltimore, MD, USA.

The perceived effort level of an action shapes everyday decisions. Despite the importance of these perceptions for decision-making, the behavioral and neural representations of the subjective cost of effort are not well understood. While a number of studies have implicated anterior cingulate cortex (ACC) in decisions about effort/reward trade-offs, none have experimentally isolated effort valuation from reward and choice difficulty, a function that is commonly ascribed to this region. Read More

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December 2018

Allosteric DNAzyme-based DNA logic circuit: operations and dynamic analysis.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Advanced Design and Intelligent Computing, Dalian University, Ministry of Education, Dalian 116622, China.

Recently, due to the dual roles of DNA and enzyme, DNAzyme has been widely used in the field of DNA circuit, which has a wide range of applications in bio-engineered system, information processing and biocomputing. In fact, the activity of DNAzymes was regulated by subunits assembly, pH control and metal ions triggers. However, those regulations required to change the sequences of whole DNAzyme, as separating parts and inserting extra DNA sequence. Read More

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December 2018

In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Miller Research Building Molecular Imaging Service Center, Johns Hopkins University, Baltimore, Maryland.

Preclinical noninvasive imaging can be an indispensable tool for studying animal models of disease. In vivo imaging to assess anatomical, functional, and molecular features requires verification by a comparison to the macroscopic and microscopic morphological features, since all noninvasive in vivo imaging methods have much lower resolution than standard histopathology. Comprehensive pathological evaluation of the animal model is underutilized; yet, many institutions have veterinary or human pathologists with necessary comparative pathology expertise. Read More

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December 2018

Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial.

J Gerontol A Biol Sci Med Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Background: Low-grade chronic inflammation, characterized by elevations in plasma Interleukin-6 (IL-6), is an independent risk factor of impaired mobility in older persons. Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (ω-3) may reduce IL-6 and may potentially improve physical function. To assess the main effects of the angiotensin receptor blocker losartan and ω-3 as fish oil on IL-6 and 400 m walking speed, we conducted the ENRGISE Pilot multicenter randomized clinical trial. Read More

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December 2018
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Backscattered electron imaging of high pressure frozen soybean root nodules visualizes formation of symbiosome membranes.

Microscopy (Oxf) 2018 Dec 12. Epub 2018 Dec 12.

Comprehensive Analysis Center for Science, Saitama University, Saitama, Japan.

High-pressure frozen soybean root nodules were fractured and backscattered electron images were obtained from uncoated samples in a low vacuum scanning electron microscope equipped with a cryo-transfer system. Structures of infected cells were well preserved: numerous symbiosomes, as well as nuclei, plastids and mitochondria were observed without ice crystal damage. After appropriate sublimation of water, bacteria included in symbiosomes were visualized. Read More

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December 2018

Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.

Digestion 2018 Dec 12:1-10. Epub 2018 Dec 12.

Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Background/aims: Behçet's disease (BD) with intestinal lesions and Crohn's disease (CD) share clinical features. However, no report has compared the 2 diseases with regard to lesions of the upper gastrointestinal tract (UGT). We aimed to evaluate endoscopic and histologic findings of UGT in CD and BD. Read More

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December 2018

Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study.

PLoS One 2018 12;13(12):e0208796. Epub 2018 Dec 12.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.

Background: The number of patients with diabetes is increasing particularly in Asia-Pacific region. Many of them are treated with antidiabetics. As the basis of the studies on the benefit and harm of antidiabetic drugs in the region, the information on patterns of market penetration of new classes of antidiabetic medications is important in providing context for subsequent research and analyzing and interpreting results. Read More

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December 2018

An integrated method for understanding the function of macro-lithic tools. Use wear, 3D and spatial analyses of an Early Upper Palaeolithic assemblage from North Eastern Italy.

PLoS One 2018 12;13(12):e0207773. Epub 2018 Dec 12.

Department of Oral and Maxillofacial Sciences, Diet and Ancient Technology Laboratory (DANTE), Sapienza University, Rome, Lazio, Italy.

The article presents an original analysis which combines use-wear, 3D modelling and spatial analyses to experimental archaeology in order to investigate Early Upper Palaeolithic flint-knapping gestures and techniques involving the use of macro-lithic tools. In particular, the methodological framework proposed in this paper was applied to the study of Protoaurignacian and Aurignacian macro-tools from Fumane Cave (Verona, Italy). Combining spatial analysis and use wear investigation, both at low and high magnifications, permitted the identification and detailed description of the use-related traces affecting both the hammerstones and retouchers which, at Fumane Cave, were used at different stages during flint tool production. Read More

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December 2018

What are the sympatric mechanisms for three species of terrestrial hermit crab (Coenobita rugosus, C. brevimanus, and C. cavipes) in coastal forests?

PLoS One 2018 12;13(12):e0207640. Epub 2018 Dec 12.

Graduate Institute of Environmental Education, National Taiwan Normal University, Taipei City, Taiwan, ROC.

Terrestrial hermit crabs play a significant role in coastal ecology. For example, as seed dispersers and debris scavengers in coastal forests, they accelerate the decomposition of organic substances. In the Indo-Pacific Ocean, Coenobita rugosus, C. Read More

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December 2018

Systemic involvement in ACS: Using CMR imaging to compare the aortic wall in patients with and without acute coronary syndrome.

PLoS One 2018 12;13(12):e0203514. Epub 2018 Dec 12.

Division of Cardiology, Institute for Cardiology and Cardiac Surgery, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, United States of America.

Background/objectives: Previous studies have demonstrated that in acute coronary syndrome (ACS), plaque destabilization and vessel inflammation, represented by vessel edema, often occur simultaneously in multiple coronaries, as well as extend to the cerebrovascular system. Our aim was to determine whether the inflammatory vascular processes occurring within the coronaries during ACS extend simultaneously to the descending aorta.

Methods: We prospectively enrolled 111 patients (56 ACS patients and 55 non-ACS patients with known coronary artery disease) to undergo cardiac magnetic resonance of the thoracic aortic wall at presentation and at three-month follow-up. Read More

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December 2018

High Prevalence of Spinal Magnetic Resonance Imaging Findings in Asymptomatic Young Adults (18-22 Yrs) Candidate to Air Force Flight.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Headquarters Joint Force Command (HQ JFC) of the North Atlantic Treaty Organization (NATO), Lago Patria, Giugliano in Campania (NA), Italy.

Study Design: Cross-sectional, retrospective, magnetic resonance (MR) imaging study, performed during cadets' selection procedures of the Italian Air Force Academy.

Objective: To assess the prevalence of spinal MR imaging findings in asymptomatic young adults (18-22 yrs) candidate to Air Force Flight.

Summary Of Background Data: Spinal MR imaging findings are frequently detected in asymptomatic subjects. Read More

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December 2018

Clinical Management of Pediatric Achalasia: A Survey of Current Practice.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology.

Objectives: Pediatric achalasia is a rare neurodegenerative disorder of the esophagus that requires treatment. Different diagnostic and treatment modalities are available, but there are no data that show how children can best be diagnosed and treated. We aimed to identify current practices regarding the diagnostic and therapeutic approach toward children with achalasia. Read More

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December 2018

Social Stress Affects Colonic Inflammation, the Gut Microbiome, and Short Chain Fatty Acid Levels and Receptors.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Center for Microbial Pathogenesis, The Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.

Objectives: Gastrointestinal disorders, such as inflammatory bowel diseases (IBD) and functional gastrointestinal disorders (FGID), involve disrupted homeostatic interactions between the microbiota and the host. Both disorders are worsened during stress, and in laboratory mice, stress exposure has been shown to change the composition of the gut microbiome. Stress-induced changes to the microbiome exacerbate intestinal inflammation and alter intestinal motility in mice. Read More

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December 2018

Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Section of Pediatric Gastroenterology and Nutrition, Texas Children's Hospital, Baylor College of Medicine, Children's Nutrition and Research Center, Houston, TX.

Fecal microbiota transplantation (FMT) is becoming part of the treatment algorithms against recurrent Clostridium difficile infection (rCDI) both in adult and pediatric gastroenterology practice. With our increasing recognition of the critical role the microbiome plays in human health and disease, FMT is also being considered as a potential therapy for other disorders, including inflammatory bowel disease (Crohn disease, ulcerative colitis), graft versus host disease, neuropsychiatric diseases, and metabolic syndrome. Controlled trials with FMT for rCDI have not been performed in children, and numerous clinical and regulatory considerations have to be considered when using this untraditional therapy. Read More

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December 2018

Application of the ConNECT Framework to Precision Health and Health Disparities.

Nurs Res 2018 Dec 12. Epub 2018 Dec 12.

Professor and Associate Vice Dean of Research, University of South Florida College of Nursing, Tampa, FL Founding Director, Center of Community Alliance for Research Education, Professor, Department of Population Sciences, Beckman Research Institute, City of Hope Medical Center, Duarte, CA Associate Professor, The Ohio State University, College of Nursing, Columbus, OH Department of Health Outcomes and Behavior, Division of Population Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612 Assistant Professor, College of Nursing, University of Utah, Salt Lake City, UT Professor, Department of Psychological Science, University of North Carolina at Charlotte, Charlotte, NC Senior Member, Division of Population Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL Department of Health Disparities Research, MD Anderson Cancer Center, Houston, TX Division of Population Science, H. Lee Moffitt Cancer Center and Research Institute & Department of Oncological Sciences, University of South Florida, College of Medicine, Tampa, FL Assistant Professor, Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY Assistant Professor, Department of Community Health Sciences, Boston University School of Public Health and Department of Social and Behavioral Sciences, and Harvard T.H. Chan School of Public Health, Boston, MA Assistant Professor, Department of Medical Social Sciences and Robert H. Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine, Chicago, IL Associate Professor, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR Staff Scientist, Project Director, Biobehavioral Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA Strategic Director of Health Disparities Research, Behavioral Research Center, American Cancer Society, Atlanta, GA.

Background: An emphasis on precision health (PH) has stimulated precision medicine studies to focus on the interplay of biological, behavioral, and environmental factors with disease risks, treatments, prognoses, and outcomes affecting health disparities. It is imperative, as well, that improving health equity among underserved populations remains central to the efforts and aims of PH.

Objectives: Apply the transdisciplinary ConNECT Framework: A model for advancing behavioral medicine science and practice to foster health equity to PH by integrating a population health agenda for reducing health disparities. Read More

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December 2018

Use of Assistive Devices to Lift, Transfer, and Reposition Hospital Patients.

Nurs Res 2019 Jan/Feb;68(1):3-12

Ashley Schoenfisch, PhD, MSPH, is Assistant Professor, Duke University School of Nursing, and Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina. Kristen L. Kucera, PhD, MSPH, ATC, LAT, is Assistant Professor, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, and Director, National Center for Catastrophic Sport Injury Research, University of North Carolina at Chapel Hill. Hester J. Lipscomb, PhD, is Professor Emeritus, Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina. Jennifer McIlvaine, PT, MSPT, CSPHA, is Physical Therapist, Safe Patient Handling Specialist, Duke Occupational and Environmental Safety Office, Durham, North Carolina. Lori Becherer, BS, is Staff Specialist, Duke Occupational and Environmental Safety Office, Durham, North Carolina, and Injury Prevention Research Center, University of North Carolina at Chapel Hill. Tamara James, MA, CPE, CSPHP, is Director, Ergonomics, Duke Occupational and Environmental Safety Office, and Assistant Professor, Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina. Susan Avent, MSN, MBA, MHA, RN, NEA-BC, is Associate Chief Nursing Officer, Quality, Duke University Health System, Durham, North Carolina.

Background: Devices to lift, transfer, and reposition patients are recommended for healthcare workers' and patients' safety, but their intended use has yet to be fully realized.

Objective: The aim of this study was to describe hospital nursing staff use of lift/transfer devices and the presence of factors at the time of lifts/transfers with potential to influence whether devices are used.

Methods: Participants were 108 US nursing staff in a university-based medical center and two community hospitals. Read More

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December 2018
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Re: Radke et al - The Translaminar Pressure Gradient - Papilledema After Trabeculectomy Treated With Optic Nerve Sheath Fenestration.

Authors:
David Fleischman

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, University of North Carolina at Chapel Hill.

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December 2018

Neurofibromatosis Type 1 Vasculopathy Presenting as Impending Central Retinal Artery Occlusion.

J Neuroophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.

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December 2018

Brain Death in Patients With "Isolated" Brainstem Lesions: A Case Against Controversy.

J Neurosurg Anesthesiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology Mayo Clinic, Division of Critical Care Neurology, Rochester, MN.

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December 2018

Narcolepsy, Anesthesia, and Sedation: A Survey of the Perioperative Experience of Patients With Narcolepsy.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

Division of Pulmonary, Critical Care and Sleep Medicine, MetroHealth Medical Center, Cleveland, Ohio.

Background: Patients with narcolepsy may be at increased perioperative risk due to the interactions among anesthesia, narcolepsy, and narcolepsy medications. This study sought to determine the perioperative experience of narcoleptic patients undergoing anesthesia or sedation, the frequency of perioperative counseling, and self-reported surgical complications.

Methods: A 22-question survey was developed by expert consensus and distributed by the Narcolepsy Network. Read More

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December 2018

Population differentiation within Anisogramma anomala in North America.

Phytopathology 2018 Dec 12. Epub 2018 Dec 12.

Rutgers The State University of New Jersey, 242612, Department of Plant Biology, New Brunswick, New Jersey, United States ;

Anisogramma anomala (Peck) E. Müller, a biotrophic ascomycete in the order Diaporthales, causes eastern filbert blight (EFB) of hazelnuts (Corylus). Until recently, little has been documented on its genetic diversity and population structure. Read More

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December 2018

Ethnic, gender, and seasonal difference in heavy drinking and protective behavioral strategies among student-athletes.

J Ethn Subst Abuse 2018 Dec 12:1-18. Epub 2018 Dec 12.

c University of North Carolina Greensboro , Greensboro , North Carolina.

Relations among gender, ethnicity, athlete seasonal status, alcohol consumption, and protective behavioral strategies were examined among student-athletes. The national sample (N = 670, M = 18.90) included Black (n = 199), Hispanic (n = 236), and White (n = 235) college student-athletes who use alcohol. Read More

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December 2018

Advancements in Life Cycle Human Exposure and Toxicity Characterization.

Environ Health Perspect 2018 Dec;126(12):125001

16 School of Public Health, University of California , Berkeley, California, USA.

Background: The Life Cycle Initiative, hosted at the United Nations Environment Programme, selected human toxicity impacts from exposure to chemical substances as an impact category that requires global guidance to overcome current assessment challenges. The initiative leadership established the Human Toxicity Task Force to develop guidance on assessing human exposure and toxicity impacts. Based on input gathered at three workshops addressing the main current scientific challenges and questions, the task force built a roadmap for advancing human toxicity characterization, primarily for use in life cycle impact assessment (LCIA). Read More

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December 2018

Incidence, Characteristics, and Outcomes of Myocardial Infarction in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.

JAMA Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Stanford, California.

Importance: Patients with peripheral artery disease (PAD) are at high risk for myocardial infarction (MI).

Objective: To characterize the incidence and types of MI in a PAD population, identify factors associated with MI, and determine the association of MI with cardiovascular mortality and acute limb ischemia.

Design, Setting, And Participants: The Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (EUCLID) was a double-blind randomized clinical trial conducted at 811 sites in 28 countries that randomized 13 885 patients with symptomatic PAD to monotherapy with ticagrelor or clopidogrel. Read More

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December 2018

Beyond reasonable drought: hotspots reveal a link between the 'Big Dry' and cryptosporidiosis in Australia's Murray Darling Basin.

J Water Health 2018 Dec;16(6):1033-1037

National Centre for Geographic and Resource Analysis in Primary Health Care, Australian National University, Canberra, 2600, Australia.

There is little evidence on how the health impacts of drought vary spatially and temporally. With a focus on waterborne cryptosporidiosis, we identify spatio-temporal hotspots and by using interrupted time series analysis, examine the impact of Australia's Big Dry (2001-2009) in these disease clusters in the Murray Darling Drainage Basin. Analyses revealed a statistically significant hotspot in the north of the Australian Capital Territory (ACT) and a hotspot in the north-eastern end of the basin in Queensland. Read More

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December 2018

Rotavirus analyses by SYBR Green real-time PCR and microbiological contamination in bivalves cultivated in coastal water of Amazonian Brazil.

J Water Health 2018 Dec;16(6):970-979

Instituto Evandro Chagas, IEC, BR-316 km 7, Ananindeua, Para, Brazil E-mail:

The contamination of mussels and oysters by viruses and bacteria is often associated with water contamination and gastroenteritis in humans. The present study evaluated viral and bacterial contamination in 380 samples, from nine mollusk-producing regions in coastal water north of the Brazilian Amazon. Rotavirus contamination was studied for groups A to H, using a two-step SYBR Green RT-qPCR (quantitative reverse transcription polymerase chain reaction), and bacterial families Enterobacteriaceae, Vibrionaceae, and Aeromonadaceae by classical and molecular methods. Read More

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December 2018

Pedobacter miscanthi sp. nov., isolated from Miscanthus sinensis.

Int J Syst Evol Microbiol 2018 Dec 12. Epub 2018 Dec 12.

3​Northwest Hubei Research Institute of Traditional Fermented Food, College of Food Science and Technology, Hubei University of Arts and Science, Xiangyang 441053, PR China.

In a survey of endophytic bacteria in Miscanthus sinensis, a strain of Gram-negative, non-endospore-forming, rod-shaped, aerobic bacterium was isolated and designated as RS10. Phylogenetic analysis based on its 16S rRNA gene sequence showed that the strain RS10 was affiliated with the genus Pedobacter and exhibited the highest sequence similarities to Pedobacter kyungheensis KACC 16221 (97.78 %), Pedobacter roseus KCTC 22187 (97. Read More

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December 2018

Nonomuraea lactucae sp. nov., a novel actinomycete isolated from rhizosphere soil of lettuce (Lactuca sativa).

Int J Syst Evol Microbiol 2018 Dec 12. Epub 2018 Dec 12.

2​State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, PR China.

A novel actinobacterium, designated strain NEAU-YG30, was isolated from the rhizosphere soil of lettuce collected in Heilongjiang province, north-east China. The taxonomic position of the strain was investigated using a polyphasic approach. On the basis of 16S rRNA gene sequence analysis, strain NEAU-YG30 belongs to the genus Nonomuraea, and shared highest sequence similarity to Nonomuraea muscovyensis KCTC 29233 (97. Read More

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December 2018

Smaller left anterior cingulate cortex in non-bipolar relatives of patients with bipolar disorder.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Objective: Bipolar disorder (BD) is highly heritable. The present study aimed at identifying brain morphometric features that could represent markers of BD vulnerability in non-bipolar relatives of bipolar patients.

Methods: In the present study, structural magnetic resonance imaging brain scans were acquired from a total of 93 subjects, including 31 patients with BD, 31 non-bipolar relatives of BD patients, and 31 healthy controls. Read More

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December 2018

Child and Adolescent Psychosocial Care Center service use profile in Brazil: 2008 to 2012.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Instituto de Saúde Coletiva (ISC), Universidade Federal da Bahia (UFBA), Salvador, Bahia, Brazil.

Objective: To describe the service use profile of Child and Adolescent Psychosocial Care Centers (Centro de Atenção Psicossocial Infanto-Juvenil [CAPSi]) in Brazil regarding diagnostic categories, sociodemographic aspects, and care modalities between 2008 and 2012.

Methods: A descriptive, ecological study was performed using data from the Unified Health System regarding high-complexity procedure authorizations (Autorização de Procedimentos de Alta Complexidade [APAC]) for the period from 2008-2012. The variables sex, age, diagnosis (F00-F99 of ICD-10), and type of care provided were examined. Read More

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December 2018

Incidence and type of health care associated injuries among nursing students: an experience in northern Italy.

Acta Biomed 2018 Dec 7;89(7-S):41-49. Epub 2018 Dec 7.

Corso di Laurea in Infermieristica Università di Bologna - Faenza.

Background And Aim Of The Study: Nursing students are at high risk of injury while on clinical placement. The incidence of injury is three times higher in comparison to other healthcare workers, with a prevalence ranging from 25% up to 33,2%. Lack of knowledge and of experience in delivering nursing care, anxiety and unfamiliarity with the clinical environment all represent risk factors for injury. Read More

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December 2018

Effect of directly observed oral iron supplementation during pregnancy on iron status in a rural population in Haryana: A randomized controlled trial.

Indian J Public Health 2018 Oct-Dec;62(4):287-293

Professor and Former Head, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background: In India, more than half of the pregnant women suffer from anemia. Low compliance to iron supplementation is one of the important reasons.

Objectives: The objective of the study is to estimate the reduction in the prevalence of anemia, improvement in iron status, and to compare the compliance to oral iron supplementation during pregnancy between directly observed iron-folic acid (IFA) supplementation group and control group. Read More

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December 2018

Vaccine hesitancy for childhood vaccinations in slum areas of Siliguri, India.

Indian J Public Health 2018 Oct-Dec;62(4):253-258

Professor and Head, Department of Community Medicine, North Bengal Medical College and Hospital, Siliguri, West Bengal, India.

Background: Despite evidence regarding the beneficial effects of vaccines, vaccination uptake has not been up to the mark across the globe in various sociocultural and sociodemographic groups. Logistics and workforce have been issues of concern to public health managers, but the latent issue of vaccine hesitancy leading to vaccine delays and refusals has not been widely addressed particularly in the Indian context.

Objectives: The present study was conducted to find out the proportion and factors contributing to vaccine hesitancy for childhood vaccinations in slums of Siliguri, India. Read More

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December 2018

Glutathione S-transferase M1 and T1 null genotypes and bladder cancer risk: A meta-analysis in a single ethnic group.

J Cancer Res Ther 2018 Dec;14(Supplement):S993-S997

Department of Urology, Wenzhou People's Hospital, Wenzhou, Zhejiang, China.

Aim Of Study: To further evaluate the influence of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null genotypes on bladder cancer risk, we conducted a meta-analysis in the Chinese population.

Materials And Methods: PubMed and Chinese databases were electronically searched through April 2016.

Results: Nine studies were included for our meta-analysis, involving 1646 bladder cancer cases and 1938 controls. Read More

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December 2018

Association of G-protein coupled purinergic receptor P2Y2 with ischemic stroke in a Han Chinese population of North China.

Neural Regen Res 2019 Mar;14(3):506-512

Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.

The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese population. In this study, clinical data and peripheral blood specimens were collected from 378 ischemic stroke patients and 344 controls. Read More

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Basics on the use of acid-sensing ion channels' inhibitors as therapeutics.

Neural Regen Res 2019 Mar;14(3):395-398

North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA.

Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases such as stroke, inflammation, arthritis, cancer, and recently migraine. More interestingly, acid-sensing ion channels may explain the sex differences in pain between males and females. Read More

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Dynamic prediction of transition to psychosis using joint modelling.

Schizophr Res 2018 Dec 7;202:333-340. Epub 2018 Jul 7.

Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, The University of Melbourne, Australia.

Considerable research has been conducted seeking risk factors and constructing prediction models for transition to psychosis in individuals at ultra-high risk (UHR). Nearly all such research has only employed baseline predictors, i.e. Read More

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December 2018

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia.

Schizophr Res 2018 Dec 6;202:173-179. Epub 2018 Jul 6.

Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States of America; Department of Psychiatry, University of Cincinnati, United States of America.

Background: Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing. Abnormalities in these hormones are observed in schizophrenia and may contribute to multiple established sex differences associated with the disorder. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients. Read More

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December 2018

Meta-Analysis of Effects of Digoxin on Survival in Patients with Atrial Fibrillation or Heart Failure: An Update.

Am J Cardiol 2019 Jan 4;123(1):69-74. Epub 2018 Oct 4.

University Hospital Frankfurt, Goethe University, Frankfurt, Germany. Electronic address:

In 2015, 3 independent meta-analyses raised concerns about digoxin therapy being associated with an increased mortality risk in patients with atrial fibrillation (AF) and with heart failure (HF). Although several other studies have been published since then fostering these safety issues, the most recent 2016 European guidelines for AF still recommend this therapy as a class I indication. We performed an updated systematic review and random-effect meta-analysis on publications up to March 2018 reporting data on digoxin associated mortality in subjects with AF or HF. Read More

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January 2019
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Relation of Length of Stay to Unplanned Readmissions for Patients Who Undergo Elective Percutaneous Coronary Intervention.

Am J Cardiol 2019 Jan 27;123(1):33-43. Epub 2018 Sep 27.

Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, United Kingdom; Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom. Electronic address:

The cost of inpatient percutaneous coronary interventions (PCI) procedure is related to length of stay (LOS). It is unknown, how LOS may be associated with readmission rates and costs of index PCI and readmissions in elective PCI. This study aims to evaluate rates, predictors, causes, and costs associated with 30-day unplanned readmissions according to lLOS in patients, who underwent elective PCI. Read More

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January 2019

Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis.

Am J Cardiol 2019 Jan 27;123(1):139-144. Epub 2018 Sep 27.

Division of Cardiology, Wayne State University/Detroit Medical Center, Detroit, Michigan.

A significant proportion of patients with acute myocarditis experience sudden cardiac death presumably due to cardiac arrhythmia. In this study, we explore the burden, the predictors of arrhythmia in acute myocarditis and the association between arrhythmias and adverse in-hospital outcomes. After evaluating the frequency of various tachyarrhythmias and bradyarrhythmia in myocarditis population, we built a logistic model to determine the independent predictors of arrhythmias in myocarditis and a 1:1 propensity-matched analysis to examine the impact of arrhythmias. Read More

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January 2019

Psychometric Evaluation of PROMIS Sexual Function and Satisfaction Measures in a Longitudinal Population-Based Cohort of Men With Localized Prostate Cancer.

J Sex Med 2018 Dec 24;15(12):1792-1810. Epub 2018 Oct 24.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: There are multiple treatment options for men with localized prostate cancer that provide similar curative efficacy but differ in their impact on sexual functioning.

Aim: To evaluate the psychometric properties of the Patient-Reported Outcomes Measurement Information System (PROMIS) Sexual Function and Satisfaction (SexFS) measures, including items from versions 1 and 2 of the short forms.

Methods: A population-based cohort of men across North Carolina completed surveys via phone interviews at baseline (prior to treatment) and at 3, 12, and 24 months after cancer treatment initiation. Read More

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December 2018

In Brief.

Curr Probl Surg 2018 May 18;55(5):158-160. Epub 2018 May 18.

Northwest Hospital, University of Washington, Seattle, WA.

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Cryoballoon Ablation for the Treatment of Atrial Fibrillation: A Meta-Analysis.

Curr Cardiol Rev 2018 Dec 11. Epub 2018 Dec 11.

Division of Cardiology, Nassau University Medical Center, East Meadow, NY. United States.

Background: Ablation therapy is the treatment of choice in antiarrhythmic drug refractory atrial fibrillation (AF). It is performed by either cryoballoon ablation (CBA) or radiofrequency ablation. CBA is gaining popularity due to simplicity with similar efficacy and complication rate compared with RFA. Read More

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December 2018

Use of anti-platelet agents in the prevention of hepatic fibrosis in patients at risk for chronic liver disease: a systematic review and meta-analysis.

Hepatol Int 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.

Background And Aims: While the association between platelet activation and hepatic fibrosis has been previously demonstrated in animal studies; the utility of anti-platelet agents in reversing the progression of hepatic fibrosis requires further review. Utilizing systematic review methods, we provide to our knowledge the first meta-analysis combining evidence from all studies aimed to establish the effect of anti-platelet agents in the prevention of hepatic fibrosis.

Methods: We searched Medline, EMBASE and PubMed databases from inception to October 2018 to identify all studies aimed at evaluating the role of anti-platelet agents in the prevention of hepatic fibrosis. Read More

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December 2018
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