Search Our Scientific Publications & Authors

Front Psychol 2020 11;11:201. Epub 2020 Mar 11.

Institute of Primary Care, University Hospital Zurich, Zurich, Switzerland.

The present study aimed to investigate the effects of intensive effort on egocentric distance perception according to different angles of view after sleep deprivation at the beginning (SDB) or at the end (SDE) of the night and after a normal sleep night (NNS). Ten male students soccer players (age 22.8 ± 1. Read More

PLoS Genet 2020 03 11;16(3):e1008270. Epub 2020 Mar 11.

Department of Biological Sciences, Florida Atlantic University, Jupiter, Florida, United States of America.

Sleep is a nearly universal behavior that is regulated by diverse environmental stimuli and physiological states. A defining feature of sleep is a homeostatic rebound following deprivation, where animals compensate for lost sleep by increasing sleep duration and/or sleep depth. The fruit fly, Drosophila melanogaster, exhibits robust recovery sleep following deprivation and represents a powerful model to study neural circuits regulating sleep homeostasis. Read More

Bratisl Lek Listy 2020 ;121(2):164-169

Objective: Cerebrospinal fluid (CSF) contains proliferation, differentiation and maturation signals that are essential factors for brain development. Due to presence of such factors this fluid has proliferative and differentiation potential. A previous study showed that maternal sleep deprivation (MSD) decrease the number of newborn neurons in development of hippocampus. Read More

Oxid Med Cell Longev 2019 14;2019:4569614. Epub 2019 Dec 14.

Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.

Sleep deprivation is reported to cause oxidative stress and is hypothesized to induce subsequent aging-related diseases including chronic inflammation, Alzheimer's disease, and cardiovascular disease. However, how sleep deprivation contributes to the pathogenesis of sleep deficiency disorder remains incompletely defined. Accordingly, more effective treatment methods for sleep deficiency disorder are needed. Read More

Reprod Biol Endocrinol 2020 Jan 11;18(1). Epub 2020 Jan 11.

Clinical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

Purpose: Male fertility is multifaceted and its integrity is as well multifactorial. Normal spermatogenesis is dependent on competent testicular function; namely normal anatomy, histology, physiology and hormonal regulation. Lifestyle stressors, including sleep interruption and even deprivation, have been shown to seriously impact male fertility. Read More

FASEB J 2020 01 27;34(1):853-864. Epub 2019 Nov 27.

Department of Physiology and Biophysics, College of Medicine, Inha University, Incheon, Korea.

Sleep is an evolutionarily conserved physiological process implicated in the consolidation of learning and memory (L/M). Here, we report that sleep deprivation (SD)-induced cognitive deficits in zebrafish are mediated through reduction in O-GlcNAcylation of brain. Microarray-based gene expression profiling of zebrafish brain demonstrated significant changes in genes involved in metabolism by SD or fear conditioning (FC), compared to the control group. Read More

Sleep 2020 Jan 2. Epub 2020 Jan 2.

Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.

Study Objective: Identify small molecule biomarkers of insufficient sleep using untargeted plasma metabolomics in humans undergoing experimental insufficient sleep.

Methods: We conducted a cross-over laboratory study where 16 normal weight participants (8 men; age 22 ± 5 years; body mass index < 25 kg/m2) completed three baseline days (9h sleep opportunity per night) followed by five day insufficient (5h sleep opportunity per night) and adequate (9h sleep opportunity per night) sleep conditions. Energy balanced diets were provided during baseline, with ad libitum energy intake provided during the insufficient and adequate sleep conditions. Read More

PLoS One 2019 27;14(12):e0226220. Epub 2019 Dec 27.

Department of Neurology, Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom.

Study Objectives: Normal timing and duration of sleep is vital for all physical and mental health. However, many sleep-related studies depend on self-reported sleep measurements, which have limitations. This study aims to investigate the association of physical activity and sociodemographic characteristics including age, gender, coffee intake and social status with objective sleep measurements. Read More

Am J Respir Crit Care Med 2020 04;201(8):976-983

INSERM, CIC 1402, Equipe Alive, Faculté de Médecine et de Pharmacie, Université de Poitiers, Poitiers, France.

Sleep deprivation can alter endurance of skeletal muscles, but its impact on respiratory command is unknown. We aimed to assess the effect of sleep deprivation on respiratory motor output and inspiratory endurance. Inspiratory endurance was investigated twice in random order, following a normal sleep night and a sleepless night. Read More

Sleep 2020 Jun;43(6)

Stress Research Institute, Stockholm University, Stockholm, Sweden.

Study Objectives: To determine how sleepiness and sleep deprivation drive the motivation to engage in different behaviors.

Methods: We studied the sleepiness of 123 participants who had been randomized to sleep deprivation or normal sleep, and their willingness to engage in a range of everyday behaviors.

Results: Self-reported sleepiness was a strong predictor of the motivation to engage in sleep-preparatory behaviors such as shutting one's eyes (OR = 2. Read More

Sci Adv 2019 11 13;5(11):eaax4249. Epub 2019 Nov 13.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

The genetic bases for most human sleep disorders and for variation in human sleep quantity and quality are largely unknown. Using the zebrafish, a diurnal vertebrate, to investigate the genetic regulation of sleep, we found that epidermal growth factor receptor (EGFR) signaling is necessary and sufficient for normal sleep levels and is required for the normal homeostatic response to sleep deprivation. We observed that EGFR signaling promotes sleep via mitogen-activated protein kinase/extracellular signal-regulated kinase and RFamide neuropeptide signaling and that it regulates RFamide neuropeptide expression and neuronal activity. Read More

Brain Topogr 2019 11 29;32(6):998-1012. Epub 2019 Oct 29.

Neuropsychology and Functional Neuroimaging Research Unit (UR2NF) at CRCN-Center for Research in Cognition and Neurosciences and UNI-ULB Neurosciences Institute, Université Libre de Bruxelles, Brussels, Belgium.

Functional near-infrared spectroscopy (fNIRS) is an optical diffusion technique that allows the non-invasive imaging of cortical activity. During the last two decades, rapid technical and methodological advances have made fNIRS a powerful tool to investigate the cerebral correlates of human performance and cognitive functions, including fatigue, sleep deprivation and social cognition. Despite intrinsic limitations such as restricted brain depth and spatial resolution, its applicability, low cost, ecological validity, and tolerance to movements make fNIRS advantageous for scientific research and clinical applications. Read More

J Sports Sci 2019 Dec 5;37(23):2726-2734. Epub 2019 Sep 5.

Sport, Physical Activity and Health Research Centre, Newman University , Birmingham , UK.

This study investigated the effects of complete and partial sleep deprivation on multiple aspects of athletic performance. Ten males completed a cognitive function test, maximal handgrip strength, countermovement jump (CMJ) and a 15 min all out cycling test to assess aerobic performance. These tests were performed following 3 different sleep conditions; normal sleep (CON), a 4 hr sleep opportunity (PART) and complete sleep deprivation (DEP). Read More

J Sports Sci 2019 Dec 16;37(23):2691-2701. Epub 2019 Sep 16.

Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University , Geelong , Australia.

This study investigated effects of total sleep deprivation on self-paced endurance performance, and heart rate (HR) indices of athletes' "readiness to perform". Endurance athletes (n = 13) completed a crossover experiment comprising a normal sleep (NS) and sleep deprivation (SD) condition. Each required completion of an endurance time-trial (TT) on consecutive days (D1, D2) separated by normal sleep or total sleep deprivation. Read More

J Ethnopharmacol 2019 Dec 21;245:112183. Epub 2019 Aug 21.

Departamento de Farmacologia - Universidade Federal de Goiás, Goiás, Brazil. Electronic address:

Ethnopharmacological Relevance: Hydrocotyle umbellata var.bonariensis Lam. (Hb), popularly known in Brazil as acariçoba and outside Brazil Hb by a number of names including marsh-pennywort, and many-flower, has traditionally been used in Ayurvedic medicine in the retardation of aging (Rasayana effect). Read More

Brain Behav Immun 2019 11 10;82:129-144. Epub 2019 Aug 10.

Defence Institute of Physiology & Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Lucknow Road, Timarpur, Delhi, India. Electronic address:

Background: An association between neuroinflammation, reduced adult neurogenesis, and cognitive impairment has been established in sleep deprivation (SD). Complement receptors are expressed on neuronal and glial cells, thus, regulate the neuroinflammation, neurogenesis and learning/memory. However, understanding of the effect of SD on the brain-immune system interaction associated with cognitive dysfunction and its mechanisms is obscure. Read More

Nutrients 2019 Jul 24;11(8). Epub 2019 Jul 24.

Department of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Military personnel may be exposed to circumstances (e.g., large energy deficits, sleep deprivation, cognitive demands, and environmental extremes) of external stressors during training and combat operations (i. Read More

J Appl Physiol (1985) 2019 09 11;127(3):770-780. Epub 2019 Jul 11.

Department Integrative Physiology and Neurobiology, College of Veterinary Medicine, Washington State University, Spokane, Washington.

Interleukin-1β (IL1) is a sleep regulatory substance. The IL1/IL1 type 1 receptor complex requires a receptor accessory protein (AcP) to signal. There are three isoforms of AcP. Read More

BMJ Open 2019 06 27;9(6):e026992. Epub 2019 Jun 27.

Geriatric Medicine, Radboudumc, Nijmegen, The Netherlands.

Introduction: Evidence indicates a bidirectional relationship between poor sleep and Alzheimer's disease (AD). While AD may lead to disruption of normal sleep, poor sleep in itself may play a causal role in the development of AD by influencing the production and/or clearance of the amyloid-beta (Aβ) protein. This led to the hypothesis that extended periods (>10 years) of sleep loss could lead to Aβ accumulation with subsequent cognitive AD-related decline. Read More

Med Sci Sports Exerc 2019 12;51(12):2516-2523

School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Burwood, Victoria, AUSTRALIA.

Purpose: The cumulative influence of sleep time on endurance performance remains unclear. This study examined the effects of three consecutive nights of both sleep extension (SE) and sleep restriction (SR) on endurance cycling performance.

Methods: Endurance cyclists/triathletes (n = 9) completed a counterbalanced crossover experiment with three conditions: SR, normal sleep (NS), and SE. Read More

Life Sci 2019 Sep 21;232:116594. Epub 2019 Jun 21.

Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. Electronic address:

Aims: Sleep deficiency has been reported to be associated with some oral health problems. Oral ulcers are very common lesions of the oral mucosa, which severely impact patients' quality of life. However, the association between sleep deficiency and the oral ulcer remains unknown. Read More

Neurobiol Dis 2019 10 21;130:104517. Epub 2019 Jun 21.

Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC; Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC; Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan, ROC. Electronic address:

The detrimental effects of sleep insufficiency have been extensively explored. However, only a few studies have addressed this issue in adolescents. In the present study, we examined and compared the effects of 72 h paradoxical sleep deprivation (SD) on adolescent (5 weeks old) and adult (~12 weeks old) mice. Read More

Am J Physiol Heart Circ Physiol 2019 08 31;317(2):H315-H322. Epub 2019 May 31.

Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan.

Our laboratory has previously reported that total sleep deprivation (TSD) modifies muscle sympathetic neural activity (MSNA) differently in young men and women. Because postmenopausal women are among the highest risk for hypertension, this study compares MSNA responses with TSD in older men and women. We hypothesized that TSD would alter MSNA in older adults, with greater sympathoexcitation in postmenopausal women. Read More

J Sex Med 2019 06 9;16(6):872-879. Epub 2019 May 9.

Sexual & Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, NY, NY USA. Electronic address:

Introduction: Androgen deprivation therapy (ADT) is frequently used in the treatment of prostate cancer worldwide. Variable testosterone (T) recovery profiles after ADT cessation have been cited.

Aim: To evaluate T recovery after cessation of ADT. Read More

Sleep Breath 2019 Dec 30;23(4):1331-1339. Epub 2019 Apr 30.

Department of Human & Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box: 35, 123, Muscat, Oman.

Purpose: The state of knowledge about the effect of sleep deprivation on the immune system is scarce and conflicting. It would therefore be useful to investigate the consequences of sleep deprivation on the immune system. We have studied the effect of sleep deprivation on the changes in neutrophil functions, and the ex vivo proliferative pattern of CD4 T lymphocytes in relationship with blood cytokine and chemokine levels due to the crucial role of these cells in mounting potent immune responses. Read More

PLoS One 2019 4;14(4):e0214858. Epub 2019 Apr 4.

Department of Personality and Psychological Assessment and Treatment, University of Deusto, Bilbao, Spain.

The aim of this study was to evaluate the stress suffered by medical residents as the result of being on call for 24 hours, from a multidimensional approach. Two groups of medical residents selected according to their work shift, participated in the study: one group (n = 40) was sleep-deprived after having been actively on-call for 24 hours, and another contrast group (n = 18) had performed a normal work day and were not sleep-deprived. All participants completed pre-post measures during a 24 h cycle. Read More

Brain Cogn 2019 06 30;132:89-97. Epub 2019 Mar 30.

School of Psychology, University of Ottawa, Ottawa, Canada; Brain and Mind Institute, University of Ottawa, Ottawa, Canada.

Sleep loss has a major effect on cognitive tasks that are dependent on the maintenance of active sustained attention. This study examines the effects of sleep deprivation on automatic information processing, more specifically, its effect on processes leading to involuntary auditory attention capture by task-irrelevant auditory events. Two experiments were run. Read More

Eur J Paediatr Neurol 2019 May 7;23(3):438-447. Epub 2019 Mar 7.

Pediatric Neurology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Institute for Molecular and Behavioral Neuroscience, Faculty of Medicine, University of Cologne, Cologne, Germany. Electronic address:

Background: Pathogenic variants in SCN2A are associated with various neurological disorders including epilepsy, autism spectrum disorder and intellectual disability. Few reports have recently described SCN2A-associated episodic ataxia (EA). Our study identifies its broader clinical and genetic spectrum, and describes pharmacological approaches. Read More

J Strength Cond Res 2019 May;33(5):1244-1251

Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Rodrigues, R, Franke, RA, Teixeira, BC, Macedo, RCO, Diefenthaeler, F, Baroni, BM, and Vaz, MA. Can the combination of acute alcohol intake and one night of sleep deprivation affect neuromuscular performance in healthy male adults? A cross-over randomized controlled trial. J Strength Cond Res 33(5): 1244-1251, 2019-The aim of this work was to perform a cross-over study to compare isolated and combined effects of alcohol intake and sleep deprivation on neuromuscular responses. Read More

Exp Brain Res 2019 Jun 18;237(6):1397-1407. Epub 2019 Mar 18.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Piazza di Porta San Donato, 2, 40126, Bologna, Italy.

A cellular degeneration of two thalamic nuclei belonging to the "limbic thalamus", i.e., the anteroventral (AV) and mediodorsal (MD) nuclei, has been shown in patients suffering from Fatal Familial Insomnia (FFI), a lethal prion disease characterized by autonomic activation and severe insomnia. Read More

Sleep Med Rev 2019 06 10;45:18-30. Epub 2019 Feb 10.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

This review aimed to provide a comprehensive examination of the effect of sleep restriction on metabolism-related parameters by synthesizing the emerging, best evidence. A systematic search was conducted in six electronic databases from inception to January 2018. We identified 41 randomized controlled trials using sleep restriction intervention. Read More

J Sleep Res 2019 12 27;28(6):e12837. Epub 2019 Feb 27.

Department of Neuroscience, Uppsala University, Uppsala, Sweden.

Acute sleep loss influences visual processes in humans, such as recognizing facial emotions. However, to the best of our knowledge, no study till date has examined whether acute sleep loss alters visual comfort when looking at images. One image statistic that can be used to investigate the level of visual comfort experienced under visual encoding is the slope of the amplitude spectrum, also referred to as the slope constant. Read More

J Clin Endocrinol Metab 2019 07;104(7):2801-2808

Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.

Context: Chronobiological factors may modulate the impact of sleep loss on glucose homeostasis. However, these interactions have not been systematically assessed in humans.

Objective: To assess the effect of sleep loss during the late vs early night on glucose homeostasis. Read More

Biosystems 2019 May 18;179:1-14. Epub 2019 Feb 18.

Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad, Pakistan.

Circadian clock is an exquisite internal biological clock functioning in all living organisms. Lifestyle changes such as shift work or frequent travelling might result in malfunctioning of the central and consequently the peripheral clocks leading to different metabolic disorders. Disruptions in β cell clock have been found to be a potential reason behind β cell failure that makes a person prone towards developing type 2 diabetes (T2DM). Read More

Behav Sleep Med 2020 Mar-Apr;18(2):275-286. Epub 2019 Feb 21.

Department of Psychology, Virginia Commonwealth University, Richmond, Virginia.

: College students are at increased risk for sleep disorders, including insomnia disorder and obtaining less than 6.5 hr of sleep per night by choice, or behaviorally induced insufficient sleep syndrome (BIISS). These disorders can have deleterious daytime consequences, including depression. Read More

Sleep 2019 05;42(5)

Department of Life Sciences, University of Zürich/ETH Zürich, Winterthurerstrasse, Zürich, Switzerland.

Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep-wake cycle overall, except at the diurnal start of the lights-off period, when they remained sleepier. The amount of time spent in NREM sleep and in the wake state in mice with lesioned HA neurons was unchanged over 24 hr, but the sleep-wake cycle was more fragmented. Read More

Science 2019 02 24;363(6429):880-884. Epub 2019 Jan 24.

Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of β-amyloid (Aβ) that accumulates in Alzheimer's disease (AD). Furthermore, chronic sleep deprivation (SD) increases Aβ plaques. However, tau, not Aβ, accumulation appears to drive AD neurodegeneration. Read More

Aerosp Med Hum Perform 2019 Feb;90(2):109-115

Despite the clear need for understanding how pilot sleep affects performance during long-range (LR; 12-16h) and ultra-long-range (ULR; 16+h) flights, the scientific literature on the effects of sleep loss and circadian desynchronization on pilots' sleep in commercial aviation is sparse. We assessed pilots' sleep timing, duration, and post-trip recovery on two LR and two ULR nonstop California to Australasia routes. Pilot's sleep/wake history was measured with actigraphy and verified by logbook across 8-9 d. Read More

Behav Brain Res 2019 04 11;362:152-159. Epub 2019 Jan 11.

Department of Sciences, Faculty of Natural and Applied Sciences, Notre Dame University-Louaize, Zouk Mosbeh, Lebanon. Electronic address:

Inadequate sleep is a major health concern of modern societies in view of the increased morbidity and mortality rates from physiological disturbances, including compromised adaptive immune responses. Many studies investigated the effect sleep restriction (SR) on the normal immune response in terms of leukocyte number and circulating cytokine and T helper cell (Th) profiles, but none considered the major histocompatibility complex (MHC), namely class II molecules. As no information exists about the normal temporal expression of MHC class II, the present study aimed at understanding how SR affects the adaptive immune response via altering the 1) normal daily expression profile and 2) overall constitutive levels of murine MHC class II by leukocytes' isolates from spleen and axillary lymph nodes. Read More

Behav Brain Res 2019 04 11;362:131-139. Epub 2019 Jan 11.

Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address:

Obesity and sleep disturbances comprise major health problems which are likely interrelated. Diet-induced obesity in young mice has been demonstrated to lead towards an altered sleep homeostasis. In the current study, we investigated the effect of chronic (12 weeks) high-caloric diet (HCD, 45% fat) consumption on sleep and the sleep electroencephalogram (EEG) in young and older mice (6-month-old, n = 9; 18-month-old, n = 8 and 24-month-old, n = 4) and compared with age-matched controls on normal chow (n = 11, n = 9 and n = 9 respectively). Read More

Chronobiol Int 2019 03 10;36(3):407-426. Epub 2019 Jan 10.

a Research Institute for Sport and Exercise Sciences , Liverpool John Moores University , Liverpool , UK.

We have investigated the effects that sleep restriction (3-h sleep during two consecutive nights) have on an evening (17:00 h) submaximal weightlifting session; and whether this performance improves following a 1-h post-lunch powernap. Fifteen resistance-trained males participated in this study. Before the experimental protocol commenced, 1RM bench press and inclined leg press and normative habitual sleep were recorded. Read More

Am J Clin Nutr 2019 01;109(1):17-28

Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Background: Overconsumption of energy-dense foods and sleep restriction are both associated with the development of metabolic and cardiovascular diseases, but their combined effects remain poorly evaluated.

Objective: The aim of this study was to assess whether sleep restriction potentiates the effects of a short-term overfeeding on intrahepatocellular lipid (IHCL) concentrations and on glucose homeostasis.

Design: Ten healthy subjects were exposed to a 6-d overfeeding period (130% daily energy needs, with 15% extra energy as sucrose and 15% as fat), with normal sleep (8 h sleep opportunity time) or sleep restriction (4 h sleep opportunity time), according to a randomized, crossover design. Read More

Sleep 2019 04;42(4)

Department of Sleep and Cognition, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

Study Objectives: Mechanisms underlying the distress of hyperarousal in people with insomnia remain enigmatic. We investigated whether insomnia impedes the overnight adaptation to emotional distress.

Methods: We induced the distressful self-conscious emotion of shame four times across three consecutive days by exposing 64 participants to their often embarrassingly out-of-tune singing, recorded earlier during a Karaoke session. Read More

J Prosthodont Res 2019 Apr 14;63(2):193-198. Epub 2018 Dec 14.

Division of Oral Function and Rehabilitation, Department of Oral Health Science, Nihon University School of Dentistry at Matsudo, Matsudo, Japan.

Purpose: To investigate the effect of sleep restriction on somatosensory sensitivity related to occlusion.

Methods: Twelve healthy participants participated in an experimental voluntary total sleep restriction (SR) study. In a study design, they were invited to sleep as usual, normal sleep (NS) or to restrict their sleep for four nights. Read More

J Clin Endocrinol Metab 2019 05;104(5):1687-1696

Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.

Context: Chronodisruption, as caused by such conditions as perturbations of 24-hour rhythms of physiology and behavior, may promote the development of metabolic diseases.

Objective: To assess the acute effects of sleep curtailment on circadian regulation (i.e. Read More

Neuroscience 2019 02 7;398:37-54. Epub 2018 Dec 7.

Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China. Electronic address:

Previous studies have revealed that sleep deprivation (SD) alters hippocampal functional connectivity (FC). However, the effects of SD on the FC of hippocampal subregions are still unknown. In this study, we used a masked independent component analysis (mICA) to partition the hippocampus into several small regions and investigated the changes in the FC of each small region within the whole brain after 24 h of SD in 40 normal young subjects. Read More

Sleep 2019 02;42(2)

Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA.

While it is well established that slow-wave sleep electroencephalography (EEG) rebounds following sleep deprivation, very little research has investigated autonomic nervous system recovery. We examined heart rate variability (HRV) and cardiovagal baroreflex sensitivity (BRS) during four blocks of repetitive sleep restriction and sequential nights of recovery sleep. Twenty-one healthy participants completed the 22-day in-hospital protocol. Read More

Cogn Affect Behav Neurosci 2019 04;19(2):283-295

Department of Psychology, The University of Hong Kong, Hong Kong, China.

Sleep deprivation is suggested to impact emotion regulation, but few studies have directly examined it. This study investigated the influence of sleep deprivation on three commonly used emotion regulation strategies (distraction, reappraisal, suppression) in Gross's (1998) process model of emotion regulation. Young healthy adults were randomly assigned to a sleep deprivation group (SD; n = 26, 13 males, age = 20. Read More

J Exp Biol 2019 01 8;222(Pt 1). Epub 2019 Jan 8.

Marine Biological Laboratory, Woods Hole, MA 02543, USA.

Sleep is a state of immobility characterized by three key criteria: an increased threshold of arousal, rapid reversal to an alert state and evidence of homeostatic 'rebound sleep' in which there is an increase in the time spent in this quiescent state following sleep deprivation. Common European cuttlefish, , show states of quiescence during which they meet the last two of these three criteria, yet also show spontaneous bursts of arm and eye movements that accompany rapid changes in chromatophore patterns in the skin. Here, we report that this rapid eye movement sleep-like (REMS-like) state is cyclic in nature. Read More

Clin J Am Soc Nephrol 2018 12 15;13(12):1825-1832. Epub 2018 Nov 15.

Yaizu City Hospital, Yaizu, Shizuoka, Japan.

Background And Objectives: Shorter or longer sleep duration and poor sleep quality are risk factors for numerous cardio-metabolic diseases, cardiovascular disease, and mortality in subjects with normal kidney function. The association of sleep duration and sleep quality with health outcomes in patients with CKD remains uncertain.

Design, Setting, Participants, & Measurements: A 4-year prospective cohort study in 17 nephrology centers in Japan, the CKD Japan Cohort (CKD-JAC) Study, assessed an association of self-reported sleep duration and sleep quality, on the basis of the Pittsburgh Sleep Quality Index (PSQI) questionnaire, with incidence of ESKD in 1601 patients with eGFR 10-59 ml/min per 1. Read More