1,282 results match your criteria Normal Sleep Sleep Physiology and Sleep Deprivation


Muscle temperature is least altered during total sleep deprivation in rats.

J Therm Biol 2021 May 18;98:102910. Epub 2021 Mar 18.

Department of Physiology, All India Institute of Medical Sciences, New Delhi, 110029, India; Department of Physiology, Faculty of Medicine & Health Sciences, SGT University, Gurgaon, Haryana, 122505, India. Electronic address:

It has often been said that the brain is mostly benefitted from sleep. To understand the importance of sleep, extensive studies on other organs are too required. One such unexplored area is the understanding of muscle physiology during the sleep-wake cycle. Read More

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Uterine contractile activity and fetal outcome in rats treated with vitamin C during late gestational variable stress exposure.

J Complement Integr Med 2021 May 10. Epub 2021 May 10.

Department of Physiology, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.

Objectives: Stress responses vary throughout pregnancy and impact of late gestational variable stress (LGVS) with vitamin C supplementation on uterine contractility is barely explored. This study investigates fetal weight outcome and uterine contractile responses to pharmacological agents during LGVS exposure.

Methods: Twenty four nulliparous pregnant rats were divided into four groups of six. Read More

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Association of sleep duration in middle and old age with incidence of dementia.

Nat Commun 2021 04 20;12(1):2289. Epub 2021 Apr 20.

Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France.

Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7 h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1. Read More

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Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease.

Neurobiol Dis 2021 Jul 10;155:105367. Epub 2021 Apr 10.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom. Electronic address:

Sleep disruption is a common invisible symptom of neurological dysfunction in Huntington's disease (HD) that takes an insidious toll on well-being of patients. Here we used electroencephalography (EEG) to examine sleep in 6 year old OVT73 transgenic sheep (Ovis aries) that we used as a presymptomatic model of HD. We hypothesized that despite the lack of overt symptoms of HD at this age, early alterations of the sleep-wake pattern and EEG powers may already be present. Read More

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Regular aerobic exercise counteracts endothelial vasomotor dysfunction associated with insufficient sleep.

Am J Physiol Heart Circ Physiol 2021 03 8;320(3):H1080-H1088. Epub 2021 Jan 8.

Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Colorado.

Insufficient sleep is associated with endothelial vasomotor dysfunction and increased cardiovascular risk. Regular aerobic exercise is an effective lifestyle strategy for improving endothelial function and, in turn, reducing cardiovascular risk. We tested the hypotheses that regular aerobic exercise would ) improve endothelial vasodilation and ) decrease endothelin (ET)-1-mediated vasoconstrictor tone in middle-aged adults who chronically sleep <7 h/night. Read More

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Foundations of Human Consciousness: Imaging the Twilight Zone.

J Neurosci 2021 02 28;41(8):1769-1778. Epub 2020 Dec 28.

Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland

What happens in the brain when conscious awareness of the surrounding world fades? We manipulated consciousness in two experiments in a group of healthy males and measured brain activity with positron emission tomography. Measurements were made during wakefulness, escalating and constant levels of two anesthetic agents (experiment 1, = 39), and during sleep-deprived wakefulness and non-rapid eye movement sleep (experiment 2, = 37). In experiment 1, the subjects were randomized to receive either propofol or dexmedetomidine until unresponsiveness. Read More

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February 2021

Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light- and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning.

Chronobiol Int 2021 Mar 20;38(3):426-442. Epub 2020 Dec 20.

Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.

Social jetlag (SJL) is defined as the discrepancy between social and biological rhythms and calculated by the difference between the midpoint of sleep time on working-days and free-days. Previous human and mouse studies showed SJL is positively related to evening chronotype and significantly related to smoking habit, cardiovascular risk, cognitive ability, and that SJL-mimicking conditions, simulating the real lifestyle situation of SJL in many humans, disrupt the regularity of estrous cycles of female animals. The effects of SJL-mimicking conditions on circadian rhythms and cognitive function and the reasons why the discrepancy between social and biological rhythms is involved in SJL have not yet been investigated. Read More

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Cognition and Alertness in Medical Students: Effects of a Single Night of Partial Sleep Deprivation.

Ann Neurosci 2020 Apr 9;27(2):57-62. Epub 2020 Nov 9.

AIIMS, Bhubaneswar, Odisha, India.

Background: Partial sleep deprivation is common among young adults today. Though multiple studies have stressed on the benefits of having a good sleep, medical students often compromise their sleep due to academic targets and stress. This can lead to changes in attention and cognition. Read More

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Experimental sleep loss, racial bias, and the decision criterion to shoot in the Police Officer's Dilemma task.

Sci Rep 2020 11 25;10(1):20581. Epub 2020 Nov 25.

Department of Psychology and Neuroscience, Baylor University, One Bear Place 97334, Waco, TX, 76798, USA.

Violent behavior, police brutality, and racial discrimination are currently at the forefront of society's attention, and they should be. We investigated whether mild sleep loss-as typical for many adults throughout the work week-could aggravate the socio-emotional-cognitive processes contributing to violence and discrimination. In a sample of 40 healthy young adults, we either experimentally restricted participants' sleep for four nights (6. Read More

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November 2020

Cortical gradients of functional connectivity are robust to state-dependent changes following sleep deprivation.

Neuroimage 2021 02 11;226:117547. Epub 2020 Nov 11.

PERFORM Centre, Concordia University, Montreal, Canada; Center for Studies in Behavioral Neurobiology, Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, Canada; Institut Universitaire de Gériatrie de Montréal and CRIUGM, CIUSSS du Centre-Sud-de-l'Île-de-Montréal, Montreal, Canada. Electronic address:

Sleep deprivation leads to significant impairments in cognitive performance and changes to the interactions between large scale cortical networks, yet the hierarchical organization of cortical activity across states is still being explored. We used functional magnetic resonance imaging to assess activations and connectivity during cognitive tasks in 20 healthy young adults, during three states: (i) following a normal night of sleep, (ii) following 24hr of total sleep deprivation, and (iii) after a morning recovery nap. Situating cortical activity during cognitive tasks along hierarchical organizing gradients based upon similarity of functional connectivity patterns, we found that regional variations in task-activations were captured by an axis differentiating areas involved in executive control from default mode regions and paralimbic cortex. Read More

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February 2021

Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling.

Neuroimage 2021 02 10;226:117540. Epub 2020 Nov 10.

Department of Psychology, University of Oslo, Oslo, Norway; Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway; Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway. Electronic address:

Sleep deprivation influences several critical functions, yet how it affects human brain white matter (WM) is not well understood. The aim of the present work was to investigate the effect of 32 hours of sleep deprivation on WM microstructure compared to changes observed in a normal sleep-wake cycle (SWC). To this end, we utilised diffusion weighted imaging (DWI) including the diffusion tensor model, diffusion kurtosis imaging and the spherical mean technique, a novel biophysical diffusion model. Read More

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February 2021

Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System.

J Neurosci 2020 11 23;40(48):9306-9316. Epub 2020 Oct 23.

Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111

Patients with sleeping sickness, caused by the parasite , have disruptions in both sleep timing and sleep architecture. However, the underlying cause of these sleep disturbances is not well understood. Here, we assessed the sleep architecture of male mice infected with and found that infected mice had drastically altered sleep patterns. Read More

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November 2020

Modulation of sleep-courtship balance by nutritional status in .

Elife 2020 10 21;9. Epub 2020 Oct 21.

Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, United States.

Sleep is essential but incompatible with other behaviors, and thus sleep drive competes with other motivations. We previously showed males balance sleep and courtship via octopaminergic neurons that act upstream of courtship-regulating P1 neurons (Machado et al., 2017). Read More

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October 2020

Association of sleep quality and sleep duration with serum uric acid levels in adults.

PLoS One 2020 17;15(9):e0239185. Epub 2020 Sep 17.

Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objective: To date, the association between sleep duration or sleep quality and hyperuricemia has remained unclear. In addition, sleep duration and quality were not considered concomitantly in previous studies. Thus, this study was aimed toward an examination of the association of sleep duration and quality with uric acid level in a Taiwanese population. Read More

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November 2020

Partial sleep deprivation affects endurance performance and psychophysiological responses during 12-minute self-paced running exercise.

Physiol Behav 2020 12 3;227:113165. Epub 2020 Sep 3.

Interdisciplinary Laboratory in Neurosciences, Physiology and Psychology: Physical activity, Health and learning (LINP2-2APS), UFR STAPS, UPL, Paris Nanterre University, Nanterre, France. Electronic address:

Purpose: This study aimed to investigate the effects of partial sleep deprivation (PSD) on physical performance and psychophysiological responses during 12-minute self-paced running exercise.

Methods: Twenty runners (20.8±1. Read More

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December 2020

Decreased Alertness Reconfigures Cognitive Control Networks.

J Neurosci 2020 09 12;40(37):7142-7154. Epub 2020 Aug 12.

Cambridge Consciousness and Cognition Laboratory, Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom.

Humans' remarkable capacity to flexibly adapt their behavior based on rapid situational changes is termed cognitive control. Intuitively, cognitive control is thought to be affected by the state of alertness; for example, when drowsy, we feel less capable of adequately implementing effortful cognitive tasks. Although scientific investigations have focused on the effects of sleep deprivation and circadian time, little is known about how natural daily fluctuations in alertness in the regular awake state affect cognitive control. Read More

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September 2020

[Effects of butylphthalide on microglia activation in frontal lobe of rats after chronic sleep deprivation].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2020 Mar;36(2):106-110

Department of Neurology, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China.

To evaluate the effects of butylphthalide on microglia activation and inflammatory factors in frontal lobe of rats after chronic sleep deprivation. Rats were divided into four groups(=8): control group, platform group, chronic sleep deprivation group and butylphthalide intervention group. Chronic sleep deprivation was performed in rats of chronic sleep deprivation group and butylphthalide intervention group for 18 h per day using the multiple platforms method, and sleep deprivation lasted for 28 days. Read More

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[The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2020 Mar;36(2):101-105

Department of Geriatric Neurology, Sleep Medicine Research Center, the General Hospital of the People's Liberation Army, Beijing 100853.

To investigate the effects of transcranial direct current stimulation (tDCS) on the disturbance of brain network dysfunction after sleep deprivation (SD). The experimental design of self-control was used in the study. All 16 subjects received 2 times of 24 h SD with an interval of 3 weeks. Read More

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Effects of a 30 min nap opportunity on cognitive and short-duration high-intensity performances and mood states after a partial sleep deprivation night.

J Sports Sci 2020 Nov 31;38(22):2553-2561. Epub 2020 Jul 31.

Institut Supérieur Du Sport Et De L'éducation Physique De Sfax, Université De Sfax , Sfax, Tunisie.

This study evaluated the effects of partial-sleep-deprivation (SDN) and a 30 min nap opportunity on physical and cognitive performances and mood states. Fourteen physically active students (BMI = 232.8 ± 0. Read More

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November 2020

Beyond sleep duration: Sleep timing as a risk factor for childhood obesity.

Pediatr Obes 2021 01 29;16(1):e12698. Epub 2020 Jul 29.

Department of Clinical Science, University of Bergen, Bergen, Norway.

Background: Ample evidence attests to the relationship between short sleep duration, sleep problems and childhood obesity. However, few studies have examined the association between sleep timing and obesity in children.

Objectives: To investigate how sleep duration, problems and timing relate to obesity and obesogenic behaviours in children. Read More

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January 2021

Screening of sleep assisting drug candidates with a Drosophila model.

PLoS One 2020 29;15(7):e0236318. Epub 2020 Jul 29.

Research Department, Suzhou Joekai Biotech LLC, Kunshan City, Jiangsu, China.

Lately, Drosophila has been favored as a model in sleep and circadian rhythm research due to its conserved mechanism and easily manageable operation. These studies have revealed the sophisticated parameters in whole-day sleep profiles of Drosophila, drawing connections between Drosophila sleep and human sleep. In this study, we tested several sleep deprivation protocols (mechanical shakes and light interruptions) on Drosophila and delineated their influences on Drosophila sleep. Read More

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September 2020

The impact of sleep deprivation on sexual behaviors and FAAH expression in the prefrontal cortex of male rats.

Neurosci Lett 2020 09 16;735:135254. Epub 2020 Jul 16.

Research Center of Psychiatry and Behavioral Sciences, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Sleep deprivation (SD) causes alterations in the function of the endocannabinoid (EC) system and also results in alteration in many behaviors such as increased anxiety, deteriorated alertness, memory deficits, as well as sexual behaviors. Controversial data about the effects of SD on sexual response are provided. Fatty acid amide hydrolase (FAAH), the enzymes involved in the degradation of the EC system play an important role in the function of the EC system. Read More

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September 2020

Enriched environment ameliorates memory impairments in rats after postsurgery sleep deprivation.

J Chem Neuroanat 2020 11 16;109:101850. Epub 2020 Jul 16.

The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China; The Third Central Hospitai of Tianjin, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, 83 Jintang Road, Hedong District, Tianjin 300170, China. Electronic address:

Postsurgery sleep deprivation is a common complication that severely deteriorates the quality of life of patients. Here we aim to investigate the effects and mechanism of enriched environment in ameliorating sleep deprivation and memory impairments. Hernia repair surgery was performed on rats to induce sleep deprivation. Read More

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November 2020

Effects of a 20-min Nap after Sleep Deprivation on Brain Activity and Soccer Performance.

Int J Sports Med 2020 Dec 6;41(14):1009-1016. Epub 2020 Jul 6.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhonpathom, Thailand.

We examined effects of a 20-min nap following 3 h of sleep deprivation on brain wave activity, auditory reaction time, the running-based anaerobic sprint test, leg muscle strength and the rating of perceived exertion in male college soccer players. Eleven players underwent three sleep conditions; normal sleep, sleep deprivation and 20-min nap after sleep deprivation. The sleep deprivation demonstrated an increase in the mean power of delta waves over the frontal area and a decrease in the mean power of alpha waves over the parietal area compared to the normal sleep. Read More

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December 2020

Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut.

Cell 2020 06 4;181(6):1307-1328.e15. Epub 2020 Jun 4.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

The view that sleep is essential for survival is supported by the ubiquity of this behavior, the apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep loss can be lethal. The cause of this lethality is unknown. Here we show, using flies and mice, that sleep deprivation leads to accumulation of reactive oxygen species (ROS) and consequent oxidative stress, specifically in the gut. Read More

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Glucose control upon waking is unaffected by hourly sleep fragmentation during the night, but is impaired by morning caffeinated coffee.

Br J Nutr 2020 11 1;124(10):1114-1120. Epub 2020 Jun 1.

Centre for Nutrition, Exercise & Metabolism, Department for Health, University of Bath, BathBA2 7AY, UK.

Morning coffee is a common remedy following disrupted sleep, yet each factor can independently impair glucose tolerance and insulin sensitivity in healthy adults. Remarkably, the combined effects of sleep fragmentation and coffee on glucose control upon waking per se have never been investigated. In a randomised crossover design, twenty-nine adults (mean age: 21 (sd 1) years, BMI: 24·4 (sd 3·3) kg/m2) underwent three oral glucose tolerance tests (OGTT). Read More

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November 2020

Partial sleep deprivation after an acute exercise session does not augment hepcidin levels the following day.

Physiol Rep 2020 05;8(10):e14450

School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand.

The purpose of the present study was to determine the effects of partial sleep deprivation (PSD) after an exercise session in the evening on the endurance exercise-induced hepcidin response the following morning. Ten recreationally trained males participated under two different conditions. Each condition consisted of 2 consecutive days of training (days 1 and 2). Read More

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Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.

Sci Rep 2020 05 26;10(1):8676. Epub 2020 May 26.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, 305-8575, Japan.

Although sleep is one of the most conserved behaviors, the intracellular mechanism regulating sleep/wakefulness remains unknown. We recently identified a protein kinase, SIK3, as a sleep-regulating molecule. Mice that lack a well-conserved protein kinase A (PKA) phosphorylation site, S551, showed longer non-rapid eye movement (NREM) sleep and increased NREMS delta density. Read More

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Factors associated with sleep deprivation and their impact on academic performance of hostelites of twin cities of Pakistan.

J Pak Med Assoc 2020 May;70(5):851-855

Riphah International University, Islamabad, Pakistan.

Objective: To determine the factors associated with sleep deprivation and their impact on academic performance of students living in a hostel setting.

Methods: It was a correlational study conducted from January to June, 2018 in Rawalpindi and Islamabad, Pakistan, and comprised university students of either sex aged 18-25 years who were studying at different universities of the twin cities. A semi-structured questionnaire was used along with Pittsburgh Sleep Quality Index to collect data which was analysed using SPSS 21. Read More

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The effect of fish oil on social interaction memory in total sleep-deprived rats with respect to the hippocampal level of stathmin, TFEB, synaptophysin and LAMP-1 proteins.

Prostaglandins Leukot Essent Fatty Acids 2020 06 29;157:102097. Epub 2020 Apr 29.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Fish oil (FO) is one of the richest natural sources of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). DHA is essential for brain functions and EPA has been approved for brain health. On the other hand, stathmin, TFEB, synaptophysin and LAMP-1 proteins are involved in synaptic plasticity, lysosome biogenesis and synaptic vesicles biogenesis. Read More

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