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J Clin Endocrinol Metab 2018 Dec 6. Epub 2018 Dec 6.

Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.

Context: Chronodisruption as caused by e.g. perturbations of 24h-rhythms of physiology and behavior clearly may promote the development of metabolic diseases. Read More

Front Psychol 2018 31;9:2089. Epub 2018 Oct 31.

Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway.

Experimental research exploring the sleep/pain-relationship has typically focused on total or partial sleep deprivation, hereby failing to reproduce the mere fragmented sleep pattern typically observed in patients with chronic pain. Further, little research is done on affect moderates the sleep-pain relationship after sleep fragmentation. The present study sought to clarify the relationship between pain, sleep and positive and negative affect. Read More

Front Physiol 2018 28;9:1374. Epub 2018 Sep 28.

Department of Hygiene, Epidemiology and Ergonomics, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Toruń, Poland.

The main objective of the study was to analyze the impact of sleep deprivation upon hemodynamic and autonomic parameters in subjects with normal blood pressure (BP) compared to prehypertension and hypertension at 24, 28, and 32 h of total sleep deprivation (TSD). Thirty volunteers, healthy men with current medical tests indicating the absence of disease took part in the study. After physical examination (basic neurological, clinical examination, echocardiography and doppler ultrasound of the renal arteries, evaluation of the autonomic nervous system) subjects were divided into three groups: I - normotensive, II - pre-hypertensive, III - hypertensive (age: 31. Read More

J Psychopharmacol 2018 Oct 24:269881118806300. Epub 2018 Oct 24.

Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

Background:: Caffeine is one of the most widely consumed psychostimulants, and it impacts sleep and circadian physiology.

Aim:: Caffeine is generally used chronically on a daily basis. Therefore, in the current study, we investigated the chronic effect of caffeine on sleep in mice. Read More

Int J Environ Res Public Health 2018 09 20;15(10). Epub 2018 Sep 20.

Department of Uniformed Services and Combat Sports, University of Physical Education in Warsaw, 00-968 Warszawa, Poland.

The aim of this study was to analyze changes in oxidative stress and muscle damage markers during a 36-h survival training combined with sleep deprivation. The study included 23 male students of physical education (specialty: Physical Education for Uniformed Services), randomly divided into the survival or control group. The students in the survival group completed a 36-h survival training with moderate to low physical activity, without the possibility to sleep. Read More

Stress 2018 Jun 25:1-8. Epub 2018 Jun 25.

f Division of Medical Research & Education , Cheng Hsin General Hospital , Taipei , Taiwan , Republic of China.

Prolonged paradoxical sleep deprivation (PSD) and cold stress (CS) are known to cause sympathoexcitation and increase the risk of cardiovascular disease. The present study examined the effect of PSD with CS on hemodynamic perturbations by investigating blood pressure and heart rate variability (BPV and HRV) in conscious rats. Adult male Sprague-Dawley rats were divided into three groups (n = 10, each): normal sleep (NS), PSD of 72 h, and recovery sleep of 7 days after PSD. Read More

Eur Heart J 2018 Oct;39(38):3528-3539

Center for Cardiology, Cardiology I - Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, Mainz, Germany.

Aims: Aircraft noise causes endothelial dysfunction, oxidative stress, and inflammation. Transportation noise increases the incidence of coronary artery disease, hypertension, and stroke. The underlying mechanisms are not well understood. Read More

Nat Sci Sleep 2018 29;10:143-158. Epub 2018 May 29.

School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

Rapid eye movement sleep (REMS) is a unique phenomenon essential for maintaining normal physiological processes and is expressed at least in species higher in the evolution. The basic scaffold of the neuronal network responsible for REMS regulation is present in the brainstem, which may be directly or indirectly influenced by most other physiological processes. It is regulated by the neurons in the brainstem. Read More

J Strength Cond Res 2018 May 30. Epub 2018 May 30.

National Observatory of Sports, Exercise Physiology Departement, Tunis, Tunisia.

Romdhani, M, Hammouda, O, Smari, K, Chaabouni, Y, Mahdouani, K, Driss, T, and Souissi, N. Total sleep deprivation and recovery sleep affect the diurnal variation of agility performance: The gender differences. J Strength Cond Res XX(X): 000-000, 2018-This study aimed to investigate the effects of time-of-day, 24 and 36 hours of total sleep deprivation (TSD), and recovery sleep (RS) on repeated-agility performances. Read More

Biomed Res Int 2018 22;2018:5702646. Epub 2018 Mar 22.

National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, China.

Multiple studies have established the effects of afternoon naps on cognition. However, relatively few studies have investigated the domain of executive functions. Moreover, the effects of napping on inhibition are far from conclusive. Read More

Diabetes Metab Syndr 2018 Sep 21;12(5):737-742. Epub 2018 Apr 21.

Department of Computer Science and Technology, University of Science and Technology of China, Hefei, China. Electronic address:

Purpose: Overweight and underweight are one of the leading risk factors for non-communicable diseases (NCDs), but little research on this area has been undertaken in Cambodia. Therefore, this study aimed to measure underweight and overweight and their associated risk behaviors among Cambodian high school students.

Methods: 3806 students (mean ag = 15. Read More

Dev Cogn Neurosci 2018 06 7;31:1-10. Epub 2018 Apr 7.

Department of Human Development and Family Studies, Auburn University, Auburn, AL, 36849, USA.

Sleep deprivation in youth has garnered international attention in recent years, as correlational studies have demonstrated significant relationships between lack of sleep and detrimental behavioral and academic outcomes. However, no study to date has systematically examined the neurophysiological consequences of a single night of sleep restriction (i.e. Read More

PLoS Genet 2018 04 4;14(4):e1007318. Epub 2018 Apr 4.

Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, China.

Sexually dimorphic phenotypes are a universal phenomenon in animals. In the model animal fruit fly Drosophila, males and females exhibit long- and short-sleep phenotypes, respectively. However, the mechanism is still a mystery. Read More

Neurobiol Learn Mem 2018 Mar 24. Epub 2018 Mar 24.

Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands. Electronic address:

Sleep and sleep loss have a profound impact on hippocampal function, leading to memory impairments. Modifications in the strength of synaptic connections directly influences neuronal communication, which is vital for normal brain function, as well as the processing and storage of information. In a recently published study, we found that as little as five hours of sleep deprivation impaired hippocampus-dependent memory consolidation, which was accompanied by a reduction in dendritic spine numbers in hippocampal area CA1. Read More

Sleep 2018 May;41(5)

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Study Objectives: To investigate the cumulative effect of five consecutive nights of partial sleep deprivation (PSD) on a panel of cerebrospinal fluid (CSF) biomarkers in healthy adults.

Methods: A randomized, cross-over study conducted at the University of Gothenburg. The participants (N = 13) were healthy adults (20-40 years of age) with a normal sleeping pattern. Read More

Medicine (Baltimore) 2018 Feb;97(6):e9444

Department of Anesthesiology and Pain medicine, Korea University, Guro Hospital, Seoul, Republic of Korea.

Intractable hiccups, although rare, may result in severe morbidity, including sleep deprivation, poor food intake, respiratory muscle fatigue, aspiration pneumonia, and death. Despite these potentially fatal complications, the etiology of intractable hiccups and definitive treatment are unknown. This study aimed to evaluate the effectiveness of continuous cervical epidural block in the treatment of intractable hiccups. Read More

Arch Endocrinol Metab 2017 Dec;61(6):623-627

Laboratório de Investigação em Metabolismo e Diabetes (LIMED), Gastrocentro, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.

Objective: The poor quality of sleep and the deprivation thereof have been associated with disruption of metabolic homeostasis, favoring the development of obesity and type 2 diabetes (T2DM). We aimed to evaluate the influence of biliopancreatic diversion (BPD) surgery on sleep quality and excessive daytime sleepiness of obese patients with T2DM, comparing them with two control groups consisting of obese and normal weight individuals, both normal glucose tolerant.

Subjects And Methods: Forty-two women were divided into three groups: LeanControl (n = 11), ObeseControl (n = 13), and ObeseT2DM (n = 18). Read More

Neuroimage 2018 05 31;172:461-469. Epub 2018 Jan 31.

School of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing, 400715, China. Electronic address:

Sleep deprivation (SD) has been associated with cognitive and emotional disruptions, however its impact on the acquisition of fear and subsequent fear memory consolidation remain unknown. To address this question, we measured human brain activity before and after fear acquisition under conditions of 24 h sleep deprivation versus normal sleep using resting-state functional magnetic resonance imaging (rs-fMRI). Additionally, we explored whether the fear acquisition-induced change of brain activity during the fear memory consolidation window can be predicted by subjective fear ratings and autonomic fear response, assessed by skin conductance responses (SCR) during acquisition. Read More

Chin J Physiol 2017 Dec;60(6):327-337

Universidade Federal do Rio Grande do Sul, Felizardo St, 750 – Porto Alegre, Rio Grande do Sul, 90690-200, Brazil.

Alcohol (ALC) intake and sleep deprivation (SDP) are conditions that cause changes in the physiological status. However, the relationship between biological markers and mood states is not entirely clear yet. The purpose of the study was to compare isolated and combined effects of ALC intake and SDP on hormonal and inflammatory responses and in changes in the state of mood. Read More

Neuroreport 2018 Jan;29(2):123-127

Defence Research and Development Canada, Toronto Research Centre.

Task switching is a ubiquitous feature of many human activities that involve multitasking. In addition, owing to occupational demands, many individuals are required to engage in task switching under various levels of sleep deprivation, such as those who work in military and medical contexts. Nevertheless, little is known about the effects that sleep loss has on the neural bases of task switching. Read More

Front Neural Circuits 2017 23;11:79. Epub 2017 Oct 23.

Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States.

Although patients with primary insomnia experience sleep disruption, they are able to maintain normal performance on a variety of cognitive tasks. This observation suggests that insomnia may be a condition where predisposing factors simultaneously increase the risk for insomnia and also mitigate against the deleterious consequences of waking. To gain insight into processes that might regulate sleep and buffer neuronal circuits during sleep loss, we manipulated three genes, (, () and the GABA receptor (), that were differentially modulated in a model of insomnia. Read More

Arch Iran Med 2017 Sep;20(9):581-588

Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran, Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran, Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Serotonin receptors such as 5-HT3 plays critical role in regulation of sleep, wake cycle and cognitive process. Thus, we investigated the role of CA1 5HT3 serotonin receptors in memory acquisition deficit induced by total sleep deprivation (TSD; for 24 hour) and REM sleep deprivation (RSD; for 24 hour). Pain perception and locomotor activity were also assessed as factors that may affect the memory process. Read More

Acta Clin Croat 2016 09;55(3):469-473

Clinical Unit for Rehabilitation of Traumatology Patients, Clinical Department of Rheumatology, Physical Medicine and Rehabilitation, Sestre milosrdnice University Hospital Center, Zagreb, Croatia

Each sleep phase is characterized by specific chemical, cellular and anatomic events of vital importance for normal neural functioning. Different forms of sleep deprivation may lead to a decline of cognitive functions in individuals. Studies in this field make a distinction between total sleep deprivation, chronic sleep restriction, and the situation of sleep disruption. Read More

Brain Topogr 2018 03 5;31(2):257-269. Epub 2017 Oct 5.

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr. 190, 8057, Zurich, Switzerland.

Slow waves are a salient feature of the electroencephalogram (EEG) during non-rapid eye movement (non-REM) sleep. The aim of this study was to assess the topography of EEG power and the activation of brain structures during slow wave sleep under normal conditions and after sleep deprivation. Sleep EEG recordings during baseline and recovery sleep after 40 h of sustained wakefulness were analyzed (eight healthy young men, 27 channel EEG). Read More

Sleep 2017 10;40(10)

Center for Studies in Behavioral Neurobiology and Department of Exercise Science, Concordia University, Montreal, Quebec, Canada.

Study Objectives: Idiopathic hypersomnia is characterized by excessive daytime sleepiness, despite normal or long sleep time. Its pathophysiological mechanisms remain unclear. This pilot study aims at characterizing the neural correlates of idiopathic hypersomnia using single photon emission computed tomography. Read More

Med Educ Online 2017 ;22(1):1379345

a Department of Psychiatry , Jichi Medical University , Shimotsuke , Japan.

Background: Overwork, fatigue, and sleep deprivation due to night duty are likely to be detrimental to the performance of medical residents and can consequently affect patient safety.

Objective: The aim of this study was to determine the possibility of deterioration of cerebral function of sleep-deprived, fatigued residents using neuroimaging techniques.

Design: Six medical residents were instructed to draw blood from artificial vessels installed on the arm of a normal cooperator. Read More

Sleep Breath 2018 05 23;22(2):353-359. Epub 2017 Sep 23.

Aerospace Medicine Research Center, Medical Faculty of Aerospace and Subaquatic Medicine, AJA Medical Sciences University, Tehran, Iran.

Introduction: REM sleep deprivation (SD) decreases tolerance of the rat heart to ischemia-reperfusion (IR) injury; the underlying mechanisms, however, are unknown. This study aimed at determining whether changes in iNOS, Bax, and Bcl-2 gene expression are involved in this detrimental effect.

Method: SD was induced by flowerpot technique for a period of 4 days. Read More

Chronobiol Int 2017 21;34(9):1187-1196. Epub 2017 Sep 21.

b Gihoku Kousei Hospital , Gifu , Japan.

It has been hypothesized that disruption of circadian rhythms affects human health. Shift work and sleep deprivation are thought to disrupt the normal light-dark cycle, although the disruption due to shiftwork may be dependent on sleep deprivation. Both conditions have been suggested to be associated with an increased risk of cardiometabolic disorders. Read More

Atherosclerosis 2017 Oct 18;265:41-46. Epub 2017 Aug 18.

Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA; Department of Medicine, University of Colorado Denver Anschutz Medical Center, Aurora, CO 80045, USA.

Background And Aims: Habitual short nightly sleep duration is associated with increased atherosclerotic cardiovascular disease risk and morbidity. Vascular endothelial dysfunction represents an important mechanism that may underlie this heightened cardiovascular risk. Impaired endothelium-dependent vasodilation, particularly NO-mediated vasodilation, contributes to the development and progression of atherosclerotic vascular disease and acute vascular events. Read More

Brain Inj 2017 27;31(12):1625-1631. Epub 2017 Jul 27.

a Faculté Saint Charles , Aix Marseille Univ, CNRS, LNIA UMR 7260, Lab. de Neurosciences Intégratives et Adaptatives , FR3C , Marseille , France.

Primary Objective: The present study explores the cause of cognitive fatigue in persons with traumatic brain injury (TBI), as also in persons with Multiple Sclerosis (MS). Since cognitive fatigue shares many symptoms with chronic sleep deprivation (best described as cumulative excess wakefulness), it was hypothesized that cognitive fatigue is caused by cumulative excess wakefulness because of an impaired sleep efficacy. Recent results about the nature of sleep advocate that sleep aims primarily to replenish the efficiency of cortical inhibitory synapses. Read More

Psychophysiology 2017 Nov 17;54(11):1755-1769. Epub 2017 Jul 17.

Department of Psychology, University of Bonn, Bonn, Germany.

Model systems of psychosis, such as schizotypy or sleep deprivation, are valuable in informing our understanding of the etiology of the disorder and aiding the development of new treatments. Schizophrenia patients, high schizotypes, and sleep-deprived subjects are known to share deficits in oculomotor biomarkers. Here, we aimed to further validate the schizotypy and sleep deprivation models and investigated, for the first time, their interactive effects on smooth pursuit eye movements (SPEM), prosaccades, antisaccades, predictive saccades, and measures of psychotomimetic states, anxiety, depression, and stress. Read More

Rev Neurol 2017 Jul;65(2):70-74

Hospital General Universitario Gregorio Maranon, Madrid, Espana.

Aims: To report a challenging patient a girl who developed narcolepsyy with cataplexy (NT1) and a psychosis during adolescence. To discuss diagnostic and therapeutic challenges of the comorbid cases.

Case Report: A 14-year-old girl was referred to Sleep and Epilepsy Unit for excessive daytime sleepiness, impaired nocturnal sleep, binge eating and weight gain, over the last year. Read More

Brain Behav 2017 Jun 20;7(6):e00704. Epub 2017 Apr 20.

BRAINetwork Centre for Neurocognitive SciencesSchool of Health SciencesUniversity Sains MalaysiaKubang KerianKelantanMalaysia.

Introduction: REM sleep deprivation is associated with impairment in learning and memory, and nicotine treatment has been shown to attenuate this effect. Recent studies have demonstrated the importance of DREAM protein in learning and memory processes. This study investigates the association of DREAM protein in REM sleep-deprived rats hippocampus upon nicotine treatment. Read More

Am J Physiol Regul Integr Comp Physiol 2017 Sep 21;313(3):R280-R289. Epub 2017 Jun 21.

Department of Neuroscience and Behavioral Neuroendocrinology Group, The Ohio State University Wexner Medical Center, Columbus, Ohio.

The long-term consequences of early life nicotine exposure are poorly defined. Approximately 8-10% of women report smoking during pregnancy, and this may promote aberrant development in the offspring. To this end, we investigated potential enduring effects of perinatal nicotine exposure on murine sleep and affective behaviors in adulthood (~13-15 wk of age) in C57Bl6j mice. Read More

Neurosci Lett 2017 Jul 30;653:189-194. Epub 2017 May 30.

Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Sleep deprivation (SD) is a common condition associated with a variety of nervous system diseases, and has a negative impact on emotional and cognitive function. Continuous theta burst stimulation (cTBS) is known to improve cognition and emotion function in normal situations as well as in various types of dysfunction, but the mechanism remains unknown. We used two-photon in vivo imaging to explore the effect of cTBS on glymphatic pathway clearance in normal and SD C57BL/6J mice. Read More

Neurosci Lett 2017 Jul 26;653:362-369. Epub 2017 May 26.

Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address:

Sleep fragmentation due to intermittent nocturnal arousal resulting in a reduction of total sleep time and sleep efficiency is a common symptom among people with Alzheimer's disease (AD) and elderly people with normal cognitive function. Although epidemiological studies have indicated an association between sleep fragmentation and elevated risk of AD, a relevant disease model to elucidate the underlying mechanisms was lacking owing to technical limitations. Here we successfully induced chronic sleep fragmentation in AD model mice using a recently developed running-wheel-based device and demonstrate that chronic sleep fragmentation increases amyloid β deposition. Read More

Sleep 2017 08;40(8)

Department of Biological Sciences, Florida Atlantic University, Jupiter, FL.

Study Objectives: Dysregulation of sleep is associated with metabolic diseases, and metabolic rate (MR) is acutely regulated by sleep-wake behavior. In humans and rodent models, sleep loss is associated with obesity, reduced metabolic rate, and negative energy balance, yet little is known about the neural mechanisms governing interactions between sleep and metabolism.

Methods: We have developed a system to simultaneously measure sleep and MR in individual Drosophila, allowing for interrogation of neural systems governing interactions between sleep and metabolic rate. Read More

Nat Med 2017 Jun 8;23(6):768-774. Epub 2017 May 8.

Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.

Extended daytime and nighttime activities are major contributors to the growing sleep deficiency epidemic, as is the high prevalence of sleep disorders like insomnia. The consequences of chronic insufficient sleep for health remain uncertain. Sleep quality and duration predict presence of pain the next day in healthy subjects, suggesting that sleep disturbances alone may worsen pain, and experimental sleep deprivation in humans supports this claim. Read More

Sleep Med 2017 05 10;33:134-144. Epub 2017 Feb 10.

Department of Psychology, University of Arizona, Tucson, USA; Sonoran University Center for Excellence in Developmental Disabilities, University of Arizona, Tucson, USA.

Objectives: To evaluate sleep consolidation and circadian activity rhythms in infants and toddlers with Down syndrome (DS) under light and socially entrained conditions within a familiar setting. Given previous human and animal data suggesting intact circadian regulation of melatonin across the day and night, it was hypothesized that behavioral indices of circadian rhythmicity would likewise be intact in the sample with DS.

Methods: A cross-sectional study of 66 infants and young children with DS, aged 5-67 months, and 43 typically developing age-matched controls. Read More

Neurochem Int 2017 Sep 17;108:190-198. Epub 2017 Apr 17.

School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address:

Rapid eye movement sleep (REMS) plays important role in maintenance of normal brain functions. Neurons containing various neurotransmitters in different brain regions interact to regulate this complex phenomenon in health and diseases. The number of neuronal projections, their firing rates and neurotransmitter levels vary in different brain regions under various conditions leading to normal or altered patho-physio-behavioral states. Read More

Physiol Rep 2017 Apr;5(7)

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Acute sleep deprivation (SD) alters cardiovascular autonomic control (CAC) and is associated with an increased risk of cardiovascular disorders. However, the effects of partial SD on CAC are unclear. Thus, we aimed to investigate the effects of partial SD on CAC during sleep. Read More

J Sleep Res 2017 06 31;26(3):318-321. Epub 2017 Mar 31.

Center for Advanced Research in Sleep Medicine, University of Montreal, Montreal, Canada.

Face recognition is a highly specialized capability that has implicit and explicit memory components. Studies show that learning tasks with facial components are dependent on rapid eye movement and non-rapid eye movement sleep features, including rapid eye movement sleep density and fast sleep spindles. This study aimed to investigate the relationship between sleep-dependent consolidation of memory for faces and partial rapid eye movement sleep deprivation, rapid eye movement density, and fast and slow non-rapid eye movement sleep spindles. Read More

Sleep 2017 01;40(1)

Department of Pulmonary and Sleep Medicine, Children's National Health System, Washington, DC.

Study Objectives: To examine the association between self-reported sleep duration (SD) and peer/individual factors predictive of risky behaviors (risk behavior factors) in a large socioeconomically diverse school-based sample of early adolescents.

Design, Setting, And Participants: Survey data collected from 10718 and 11240 eighth-grade students in 2010 and 2012, respectively, were analyzed.

Intervention: N/A. Read More

J Psychopharmacol 2017 04 11;31(4):418-433. Epub 2016 Nov 11.

1 Department of Psychology, University of Bonn, Bonn, Germany.

Current antipsychotic medications fail to satisfactorily reduce negative and cognitive symptoms and produce many unwanted side effects, necessitating the development of new compounds. Cross-species, experimental behavioural model systems can be valuable to inform the development of such drugs. The aim of the current study was to further test the hypothesis that controlled sleep deprivation is a safe and effective model system for psychosis when combined with oculomotor biomarkers of schizophrenia. Read More

J Alzheimers Dis 2017 ;57(3):899-906

Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Sleep is an important physiological process and beneficial in the removal of brain metabolites and functional recovery. Prior studies have shown that sleep disorders are significant risk factors for Alzheimer's disease (AD).

Objective: The present study was designed to characterize the effect of short-term total sleep deprivation (TSD) on plasma amyloid-β (Aβ) concentrations. Read More

J Pain 2017 Jul 11;18(7):844-854. Epub 2017 Mar 11.

Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Human Sleep Research Program, SRI International, Menlo Park, California.

The effect of sleep deprivation on pain sensitivity has typically been studied using total and partial sleep deprivation protocols. These protocols do not mimic the fragmented pattern of sleep disruption usually observed in individuals with clinical pain conditions. Therefore, we conducted a controlled experiment to investigate the effect of sleep fragmentation on pain perception (deep pain: forearm muscle ischemia, and superficial pain: graded pin pricks applied to the skin) in 11 healthy young women after 2 consecutive nights of sleep fragmentation, compared with a normal night of sleep. Read More

Sci Rep 2017 03 3;7:43656. Epub 2017 Mar 3.

Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Centre, 2333 ZC Leiden, The Netherlands.

Changes in sleep pattern are typical for the normal aging process. However, aged mice show an increase in the amount of sleep, whereas humans show a decrease when aging. Mice are considered an important model in aging studies, and this divergence warrants further investigation. Read More

Eur J Appl Physiol 2017 Apr 28;117(4):699-712. Epub 2017 Feb 28.

Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Cape Town, South Africa.

Purpose: The effects of sleep deprivation on physical performance are well documented, but data on the consequence of sleep deprivation on recovery from exercise are limited. The aim was to compare cyclists' recovery from a single bout of high-intensity interval training (HIIT) after which they were given either a normal night of sleep (CON, 7.56 ± 0. Read More

J Neurosci Methods 2017 Apr 24;281:33-39. Epub 2017 Feb 24.

Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Background: Slow wave sleep (SWS) plays an important role in neurophysiologic restoration. Experimentally testing the effect of SWS disruption previously required highly time-intensive and subjective methods. Our goal was to develop an automated and objective protocol to reduce SWS without affecting sleep architecture. Read More

Elife 2017 02 20;6. Epub 2017 Feb 20.

Surrey Sleep Research Centre, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.

Diagnosis and treatment of circadian rhythm sleep-wake disorders both require assessment of circadian phase of the brain's circadian pacemaker. The gold-standard univariate method is based on collection of a 24-hr time series of plasma melatonin, a suprachiasmatic nucleus-driven pineal hormone. We developed and validated a multivariate whole-blood mRNA-based predictor of melatonin phase which requires few samples. Read More