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Invest Ophthalmol Vis Sci 2022 Jun;63(6):19

Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Zhengzhou, China.

Purpose: Sleep loss markedly affects the structure and function of the lacrimal gland and may cause ocular surface disease as a common public health problem. This study aims to investigate the circadian disturbance caused by sleep loss leading to dysfunction of extraorbital lacrimal glands (ELGs).

Methods: A mouse sleep deprivation (SD) model for sleep loss studies was built in C57BL/6J male mice. Read More

Food Funct 2022 Jun 20;13(12):6648-6664. Epub 2022 Jun 20.

Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.

() has been traditionally used as folk medicine and functional food in China for more than 2000 years. The water-soluble polysaccharide is the main component of decoction. The effects and mechanisms of the water-soluble polysaccharide from (PCWP) were investigated in chronic sleep deprivation (CSD)-induced anxiety in rats. Read More

Top Cogn Sci 2022 May 30. Epub 2022 May 30.

Air Force Research Laboratory, Wright-Patterson AFB.

Most computational theories of cognition lack a representation of physiology. Understanding the cognitive effects of compounds present in the environment is important for explaining and predicting changes in cognition and behavior given exposure to toxins, pharmaceuticals, or the deprivation of critical compounds like oxygen. This research integrates physiologically based pharmacokinetic (PBPK) model predictions of caffeine concentrations in blood and tissues with ACT-R's fatigue module to predict the effects of caffeine on fatigue. Read More

CNS Neurol Disord Drug Targets 2022 May 12. Epub 2022 May 12.

Affiliated to IK Gujral Punjab Technical University Jalandhar, Punjab, India.

Sleep deprivation (SD) (also referred as insomnia) is a condition in which peoples fails to get enough sleep due to excessive yawning, facing difficulty to learn new concepts, forgetfulness as well as depressed mood. This could be occurs due to several possible reasons including medications, stress (caused by shift work). Despite the fact that sleep is important for the normal physiology, it currently affects millions of people around the world US (70 million) and Europe (45 million). Read More

Curr Biol 2022 May 2;32(10):2248-2262.e9. Epub 2022 May 2.

Chair of Cellular Circuits and Systems, Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technical University Dresden, 01307 Dresden, Germany. Electronic address:

Sleep is an essential state that allows for recuperation and survival processes. Disturbing sleep triggers stress responses that promote protective gene expression. Sleep and its deprivation grossly impact gene expression, but little is known about how normal or disturbed sleep control gene expression. Read More

Stem Cell Reports 2022 05 28;17(5):1105-1119. Epub 2022 Apr 28.

Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, School of Medicine, Xiamen University, Xiamen, Fujian 361104, China; Department of Ophthalmology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361104, China; Xiamen University Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian 361004, China. Electronic address:

Sleep deficiency, a common public health problem, causes ocular discomfort and affects ocular surface health. However, the underlying mechanism remains unclear. Herein, we identified that short-term sleep deprivation (SD) resulted in hyperproliferation of corneal epithelial progenitor cells (CEPCs) in mice. Read More

Diabetologia 2022 Jul 21;65(7):1212-1221. Epub 2022 Apr 21.

Institute for Endocrinology & Diabetes, University of Lübeck, Lübeck, Germany.

Aims/hypothesis: Attenuated counterregulation after recurrent hypoglycaemia is a major complication of diabetes treatment. As there is previous evidence for the relevance of sleep in metabolic control, we assessed the acute contribution of sleep to the counterregulatory adaptation to recurrent hypoglycaemia.

Methods: Within a balanced crossover design, 15 healthy, normal-weight male participants aged 18-35 years underwent three hyperinsulinaemic-hypoglycaemic clamps with a glucose nadir of 2. Read More

Front Behav Neurosci 2022 23;16:837523. Epub 2022 Mar 23.

Department of Biological Sciences, Vanderbilt University, Nashville, TN, United States.

Normal neurodevelopment requires precise expression of the key ubiquitin ligase gene . Comparing newly generated mouse models for downregulation (models of Angelman syndrome) vs. upregulation (models for autism), we find reciprocal effects of gene dosage on phenotypes associated with circadian rhythmicity, including the amount of locomotor activity. Read More

Zool Res 2022 May;43(3):380-390

Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Maternal sleep deprivation (MSD) is a global public health problem that affects the physical and mental development of pregnant women and their newborns. The latest research suggests that sleep deprivation (SD) disrupts the gut microbiota, leading to neuroinflammation and psychological disturbances. However, it is unclear whether MSD affects the establishment of gut microbiota and neuroinflammation in the newborns. Read More

Oxid Med Cell Longev 2022 20;2022:8133310. Epub 2022 Mar 20.

College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China.

Background: Our previous studies demonstrated that melatonin could effectively ameliorate sleep deprivation- (SD-) caused oxidative stress-mediated gut microbiota disorder and colitis. The research further clarified the mechanism of melatonin in improving colitis from the perspective of the interaction between and goblet cells.

Methods: A seventy-two hours SD mouse model with or without melatonin intervention and fecal microbiota transplantation (FMT) to explore the vital position of -goblet cell interactions in melatonin improving SD-induced colitis. Read More

Neurosci Lett 2022 04 9;776:136575. Epub 2022 Mar 9.

Departments of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:

Sleep deprivation negatively influences cognition, however, the regulatory mechanisms to counteract this effect have not been identified. IGF-1 has been shown to be anti-inflammatory and neuroprotective in CNS injury models. In this study, we determined the impact of IGF-1 on brain injury and inflammation while modeling sleep deprivation. Read More

Nutrients 2022 Feb 22;14(5). Epub 2022 Feb 22.

Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, Canada.

While the vast majority of research involving creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on creatine and the brain. Preliminary studies indicate that creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain creatine content in humans. Furthermore, creatine has shown some promise for attenuating symptoms of concussion, mild traumatic brain injury and depression but its effect on neurodegenerative diseases appears to be lacking. Read More

Saudi J Gastroenterol 2022 May-Jun;28(3):209-217

Laboratory of Neurobiology, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing, China.

Background: Intestinal inflammation caused by sleep restriction (SR) threatens human health. However, radical cure of intestinal inflammatory conditions is considerably difficult. This study focuses on the effect of melatonin on SR-induced intestinal inflammation and microbiota imbalance in mice. Read More

Pancreas 2022 01;51(1):80-89

Biotechnology Center, University of Wisconsin.

Objectives: The innate biologic clock plays a significant role in lipid metabolism, including the peripheral clock in the pancreas. However, an evaluation of the downstream lipids in the pancreatic lipidome is lacking. We sought to understand the diurnal variations of lipids within the pancreatic lipidome. Read More

Sleep Sci 2021 Jul-Sep;14(3):224-228

Trakya University, Faculty of Medicine, Department of Physiology - Edirne, Turkey.

Introduction: The effects of acute sleep deprivation on cognitive function have not been clearly elucidated. The purpose of this study was to evaluate changes in cognitive function in healthy adults after one night of sleep deprivation.

Material And Methods: Twenty-one healthy young adults (aged 18-30 years) underwent assessment of cognitive functions before and after one night of total sleep deprivation and an age- and gender-matched control group was assessed before and after a normal night sleep. Read More

Front Endocrinol (Lausanne) 2022 1;13:820939. Epub 2022 Feb 1.

Department of Otolaryngology-Head and Neck Surgery and Shanghai Key Laboratory of Sleep Disordered Breathing and Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Chronic intermittent hypoxia (CIH) and chronic sleep fragmentation (CSF) are two cardinal pathological features of obstructive sleep apnea (OSA). Dietary obesity is a crucial risk intermediator for OSA and metabolic disorders. Gut microbiota affect hepatic and adipose tissue morphology under conditions of CIH or CSF through downstream metabolites. Read More

J Sleep Res 2022 Feb 14:e13566. Epub 2022 Feb 14.

Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Obstructive sleep apnea is characterized by intermittent hypoxia and sleep disruption, leading to accelerated neurodegenerative changes and cognitive decline. Serum amyloid-beta and tau proteins, which are markers for Alzheimer's disease, have been reported to increase in patients with obstructive sleep apnea. This study compared the serum levels of amyloid-beta proteins and tau proteins in 46 cognitively normal obstructive sleep apnea patients and 30 healthy controls. Read More

Brain Res Bull 2022 03 13;180:131-146. Epub 2022 Jan 13.

Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Sleep is a universal physiological need in all species and is essential for the maintenance and recovery of various physiological functions of the body. In late years, the gut microbiota (GM), a vast and extraordinarily complex ecosystem located in human gastrointestinal tract that oversees an array of critical bodily functions, has become a popular focus among researchers. Accumulated evidences in this field have revealed that it exerts important roles in the regulation of some biological characteristics, especially metabolic, immunological and neurobehavioral functions. Read More

Int J Dev Neurosci 2022 Apr 9;82(2):133-145. Epub 2022 Jan 9.

Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Developmental life experience has long-lasting influences on the brain and behavior. The present study aims to examine the long-term effects of the enriched environment (EE), which was imposed during the adolescence period of life, on their passive avoidance and recognition memories as well as anxiety-like behaviors and hippocampal brain-derived neurotrophic factor (BDNF) levels, in sleep-deprived male rats. In the present study, the male pups were separated from their mothers in postnatal day 21 (PND21) and were housed in the standard or EE for 40 days. Read More

Elife 2021 12 13;10. Epub 2021 Dec 13.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

In the mouse, () expression in tissues peripheral to the suprachiasmatic nuclei (SCN) increases during sleep deprivation and at times of the day when animals are predominantly awake spontaneously, suggesting that the circadian sleep-wake distribution directly contributes to the daily rhythms in . We found support for this hypothesis by recording sleep-wake state alongside PER2 bioluminescence in freely behaving mice, demonstrating that PER2 bioluminescence increases during spontaneous waking and decreases during sleep. The temporary reinstatement of PER2-bioluminescence rhythmicity in behaviorally arrhythmic SCN-lesioned mice submitted to daily recurring sleep deprivations substantiates our hypothesis. Read More

Int J Environ Res Public Health 2021 11 13;18(22). Epub 2021 Nov 13.

Departamento de Enfermería, Facultad de Medicina y Ciencias de la Salud, Universidad de Extremadura, 06006 Badajoz, Spain.

Background: Shift working is associated with a profound desynchronization of circadian rhythm and in particular, night-shift work disrupts normal circadian physiology. Sleep deprivation affects the functioning of certain brain areas and thus impairs cognitive performance. The purpose of this study was to investigate the effects of the night shift on cognitive performance and cerebral oxygenation/haemodynamics. Read More

Cells 2021 09 24;10(10). Epub 2021 Sep 24.

Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, IL 60612, USA.

Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to modulate the production and function of insulin-like growth factor 1 (IGF1) and insulin. Read More

BMC Cardiovasc Disord 2021 10 7;21(1):481. Epub 2021 Oct 7.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China.

Background: Growing evidence indicates that poor sleep harms health. Early to bed and early to rise is considered as a healthy lifestyle in Chinese population. The current study aimed to examine the effects of sleep habits on acute myocardial infarction (AMI) risk and severity of coronary artery disease (CAD) in Chinese population from two centers. Read More

Sleep 2022 04;45(4)

Department of Biology, Stanford University, Stanford, CA, USA.

Down syndrome (DS) is a genetic disorder caused by the presence of all or part of the third copy of chromosome 21. DS is associated with cognitive disabilities, for which there are no drug therapies. In spite of significant behavioral and pharmacological efforts to treat cognitive disabilities, new and continued efforts are still necessary. Read More

Front Psychol 2021 13;12:720493. Epub 2021 Sep 13.

Laboratory of Pharmacology, Faculty of Medicine, University of Sfax, Sfax, Tunisia.

To investigate the effects of placebo (PLA), 20 min nap opportunity (N20), 5mg·kg of caffeine (CAF), and their combination (CAF+N20) on sleepiness, mood and reaction-time after partial sleep deprivation (PSD; 04h30 of time in bed; ) or after normal sleep night (NSN; 08h30 of time in bed; ). Twenty-three highly trained athletes ( ; 9 and ; 14) performed four test sessions (PLA, CAF, N20 and CAF+N20) in double-blind, counterbalanced and randomized order. Simple (SRT) and two-choice (2CRT) reaction time, subjective sleepiness (ESS) and mood state (POMS) were assessed twice, pre- and post-intervention. Read More

Nutrients 2021 Sep 6;13(9). Epub 2021 Sep 6.

Institute of Bioscience & Integrative Medicine, Daejeon Oriental Hospital of Daejeon University, 75, Daedeok-daero 176, Seo-gu, Daejeon 35235, Korea.

Central fatigue, which is neuromuscular dysfunction associated with neurochemical alterations, is an important clinical issue related to pathologic fatigue. This study aimed to investigate the anti-central fatigue effect of Korean red ginseng (KRG) and its underlying mechanism. Male BALB/c mice (8 weeks old) were subjected to periodic sleep deprivation (SD) for 6 cycles (forced wakefulness for 2 days + 1 normal day per cycle). Read More

Oxid Med Cell Longev 2021 10;2021:5645090. Epub 2021 Sep 10.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Many studies have shown that sleep deprivation can affect a wide range of tissues and organs, and most of these effects are related to oxidative stress. Oxidative stress can cause functional and morphological changes in cells, which are closely related to autophagy and apoptosis. In this study, we examined changes in thyroid morphology and function, oxidative stress, autophagy, and apoptosis in rats after sleep deprivation. Read More

Front Immunol 2021 3;12:727959. Epub 2021 Sep 3.

Laboratory of Tumor Immunology, Department of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

Sleep disturbance is common in patients with cancer and is associated with poor prognosis. However, the effects of sleep deprivation (SD) on immune surveillance during the development of hepatocellular carcinoma (HC) and the underlying mechanisms are not known. This was investigated in the present study using mouse models of SD and tumorigenesis. Read More

Odontology 2022 Apr 18;110(2):278-286. Epub 2021 Sep 18.

Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil.

The aim of this study was to evaluate if paradoxical sleep deprivation is able to induce tissue degeneration, inflammatory activity and apoptosis in the submandibular gland of rats. A total of 24 male Wistar rats were distributed into the following groups: group 1-control (CTRL; n = 8): the animals were not submitted to any procedures; group 2-sleep deprivation (PS; n = 8): the animals were submitted to paradoxical sleep deprivation for 96 h and group 3-recovery (R; n = 8): the animals were submitted to sleep deprivation for 96 h, followed by a period of 96 h without any intervention. The following parameters were evaluated: histopathological analysis, immunohistochemistry for Ki-67, COX-2 and cleaved caspase-3 and gene expression of TNF-α, Interleukin 6 (IL-6), Interleukin 10 (IL-10) and cytochrome C by real-time PCR. Read More

Hypertension 2021 12 7;78(6):1829-1840. Epub 2021 Sep 7.

Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder (K.A.S., A.G., N.M.D., C.R., L.M., J.J.G., C.A.D.).

[Figure: see text]. Read More