1,224 results match your criteria Normal Sleep Sleep Physiology and Sleep Deprivation


Effect of Angle of View and Partial Sleep Deprivation on Distance Perception.

Front Psychol 2020 11;11:201. Epub 2020 Mar 11.

Institute of Primary Care, University Hospital Zurich, Zurich, Switzerland.

The present study aimed to investigate the effects of intensive effort on egocentric distance perception according to different angles of view after sleep deprivation at the beginning (SDB) or at the end (SDE) of the night and after a normal sleep night (NNS). Ten male students soccer players (age 22.8 ± 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyg.2020.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078342PMC

Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity.

PLoS Genet 2020 03 11;16(3):e1008270. Epub 2020 Mar 11.

Department of Biological Sciences, Florida Atlantic University, Jupiter, Florida, United States of America.

Sleep is a nearly universal behavior that is regulated by diverse environmental stimuli and physiological states. A defining feature of sleep is a homeostatic rebound following deprivation, where animals compensate for lost sleep by increasing sleep duration and/or sleep depth. The fruit fly, Drosophila melanogaster, exhibits robust recovery sleep following deprivation and represents a powerful model to study neural circuits regulating sleep homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1008270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089559PMC

The effect of maternal sleep deprivation on differentiation of mesenchymal stem cells in the presence of neonates brain cerebrospinal fluid of Wistar rats.

Bratisl Lek Listy 2020 ;121(2):164-169

Objective: Cerebrospinal fluid (CSF) contains proliferation, differentiation and maturation signals that are essential factors for brain development. Due to presence of such factors this fluid has proliferative and differentiation potential. A previous study showed that maternal sleep deprivation (MSD) decrease the number of newborn neurons in development of hippocampus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4149/BLL_2020_024DOI Listing

Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP).

Oxid Med Cell Longev 2019 14;2019:4569614. Epub 2019 Dec 14.

Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.

Sleep deprivation is reported to cause oxidative stress and is hypothesized to induce subsequent aging-related diseases including chronic inflammation, Alzheimer's disease, and cardiovascular disease. However, how sleep deprivation contributes to the pathogenesis of sleep deficiency disorder remains incompletely defined. Accordingly, more effective treatment methods for sleep deficiency disorder are needed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/4569614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948340PMC

Attenuation of sleep deprivation dependent deterioration in male fertility parameters by vitamin C.

Reprod Biol Endocrinol 2020 Jan 11;18(1). Epub 2020 Jan 11.

Clinical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

Purpose: Male fertility is multifaceted and its integrity is as well multifactorial. Normal spermatogenesis is dependent on competent testicular function; namely normal anatomy, histology, physiology and hormonal regulation. Lifestyle stressors, including sleep interruption and even deprivation, have been shown to seriously impact male fertility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12958-020-0563-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954532PMC
January 2020

Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish.

FASEB J 2020 01 27;34(1):853-864. Epub 2019 Nov 27.

Department of Physiology and Biophysics, College of Medicine, Inha University, Incheon, Korea.

Sleep is an evolutionarily conserved physiological process implicated in the consolidation of learning and memory (L/M). Here, we report that sleep deprivation (SD)-induced cognitive deficits in zebrafish are mediated through reduction in O-GlcNAcylation of brain. Microarray-based gene expression profiling of zebrafish brain demonstrated significant changes in genes involved in metabolism by SD or fear conditioning (FC), compared to the control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201901399RRDOI Listing
January 2020

Developing preliminary blood metabolomics-based biomarkers of insufficient sleep in humans.

Sleep 2020 Jan 2. Epub 2020 Jan 2.

Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.

Study Objective: Identify small molecule biomarkers of insufficient sleep using untargeted plasma metabolomics in humans undergoing experimental insufficient sleep.

Methods: We conducted a cross-over laboratory study where 16 normal weight participants (8 men; age 22 ± 5 years; body mass index < 25 kg/m2) completed three baseline days (9h sleep opportunity per night) followed by five day insufficient (5h sleep opportunity per night) and adequate (9h sleep opportunity per night) sleep conditions. Energy balanced diets were provided during baseline, with ad libitum energy intake provided during the insufficient and adequate sleep conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/sleep/zsz321DOI Listing
January 2020

Objective sleep assessment in >80,000 UK mid-life adults: Associations with sociodemographic characteristics, physical activity and caffeine.

PLoS One 2019 27;14(12):e0226220. Epub 2019 Dec 27.

Department of Neurology, Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom.

Study Objectives: Normal timing and duration of sleep is vital for all physical and mental health. However, many sleep-related studies depend on self-reported sleep measurements, which have limitations. This study aims to investigate the association of physical activity and sociodemographic characteristics including age, gender, coffee intake and social status with objective sleep measurements. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226220PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934314PMC

Impact of Sleep Deprivation on Respiratory Motor Output and Endurance. A Physiological Study.

Am J Respir Crit Care Med 2020 04;201(8):976-983

INSERM, CIC 1402, Equipe Alive, Faculté de Médecine et de Pharmacie, Université de Poitiers, Poitiers, France.

Sleep deprivation can alter endurance of skeletal muscles, but its impact on respiratory command is unknown. We aimed to assess the effect of sleep deprivation on respiratory motor output and inspiratory endurance. Inspiratory endurance was investigated twice in random order, following a normal sleep night and a sleepless night. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201904-0819OCDOI Listing
April 2020
4 Reads

Sleepiness as motivation: a potential mechanism for how sleep deprivation affects behavior.

Sleep 2020 Jun;43(6)

Stress Research Institute, Stockholm University, Stockholm, Sweden.

Study Objectives: To determine how sleepiness and sleep deprivation drive the motivation to engage in different behaviors.

Methods: We studied the sleepiness of 123 participants who had been randomized to sleep deprivation or normal sleep, and their willingness to engage in a range of everyday behaviors.

Results: Self-reported sleepiness was a strong predictor of the motivation to engage in sleep-preparatory behaviors such as shutting one's eyes (OR = 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/sleep/zsz291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294403PMC

Evolutionarily conserved regulation of sleep by epidermal growth factor receptor signaling.

Sci Adv 2019 11 13;5(11):eaax4249. Epub 2019 Nov 13.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

The genetic bases for most human sleep disorders and for variation in human sleep quantity and quality are largely unknown. Using the zebrafish, a diurnal vertebrate, to investigate the genetic regulation of sleep, we found that epidermal growth factor receptor (EGFR) signaling is necessary and sufficient for normal sleep levels and is required for the normal homeostatic response to sleep deprivation. We observed that EGFR signaling promotes sleep via mitogen-activated protein kinase/extracellular signal-regulated kinase and RFamide neuropeptide signaling and that it regulates RFamide neuropeptide expression and neuronal activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aax4249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853770PMC
November 2019

Applications of Functional Near-Infrared Spectroscopy in Fatigue, Sleep Deprivation, and Social Cognition.

Brain Topogr 2019 11 29;32(6):998-1012. Epub 2019 Oct 29.

Neuropsychology and Functional Neuroimaging Research Unit (UR2NF) at CRCN-Center for Research in Cognition and Neurosciences and UNI-ULB Neurosciences Institute, Université Libre de Bruxelles, Brussels, Belgium.

Functional near-infrared spectroscopy (fNIRS) is an optical diffusion technique that allows the non-invasive imaging of cortical activity. During the last two decades, rapid technical and methodological advances have made fNIRS a powerful tool to investigate the cerebral correlates of human performance and cognitive functions, including fatigue, sleep deprivation and social cognition. Despite intrinsic limitations such as restricted brain depth and spatial resolution, its applicability, low cost, ecological validity, and tolerance to movements make fNIRS advantageous for scientific research and clinical applications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10548-019-00740-wDOI Listing
November 2019
6 Reads

The effects of a single night of complete and partial sleep deprivation on physical and cognitive performance: A Bayesian analysis.

J Sports Sci 2019 Dec 5;37(23):2726-2734. Epub 2019 Sep 5.

Sport, Physical Activity and Health Research Centre, Newman University , Birmingham , UK.

This study investigated the effects of complete and partial sleep deprivation on multiple aspects of athletic performance. Ten males completed a cognitive function test, maximal handgrip strength, countermovement jump (CMJ) and a 15 min all out cycling test to assess aerobic performance. These tests were performed following 3 different sleep conditions; normal sleep (CON), a 4 hr sleep opportunity (PART) and complete sleep deprivation (DEP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02640414.2019.1662539DOI Listing
December 2019

Effects of total sleep deprivation on endurance cycling performance and heart rate indices used for monitoring athlete readiness.

J Sports Sci 2019 Dec 16;37(23):2691-2701. Epub 2019 Sep 16.

Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University , Geelong , Australia.

This study investigated effects of total sleep deprivation on self-paced endurance performance, and heart rate (HR) indices of athletes' "readiness to perform". Endurance athletes (n = 13) completed a crossover experiment comprising a normal sleep (NS) and sleep deprivation (SD) condition. Each required completion of an endurance time-trial (TT) on consecutive days (D1, D2) separated by normal sleep or total sleep deprivation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02640414.2019.1661561DOI Listing
December 2019

Protective effects of Hydrocotyle umbellata var. bonariensis Lam. (Araliaceae) on memory in sleep-impaired female mice.

J Ethnopharmacol 2019 Dec 21;245:112183. Epub 2019 Aug 21.

Departamento de Farmacologia - Universidade Federal de Goiás, Goiás, Brazil. Electronic address:

Ethnopharmacological Relevance: Hydrocotyle umbellata var.bonariensis Lam. (Hb), popularly known in Brazil as acariçoba and outside Brazil Hb by a number of names including marsh-pennywort, and many-flower, has traditionally been used in Ayurvedic medicine in the retardation of aging (Rasayana effect). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.112183DOI Listing
December 2019
2 Reads

Complement activation sustains neuroinflammation and deteriorates adult neurogenesis and spatial memory impairment in rat hippocampus following sleep deprivation.

Brain Behav Immun 2019 11 10;82:129-144. Epub 2019 Aug 10.

Defence Institute of Physiology & Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Lucknow Road, Timarpur, Delhi, India. Electronic address:

Background: An association between neuroinflammation, reduced adult neurogenesis, and cognitive impairment has been established in sleep deprivation (SD). Complement receptors are expressed on neuronal and glial cells, thus, regulate the neuroinflammation, neurogenesis and learning/memory. However, understanding of the effect of SD on the brain-immune system interaction associated with cognitive dysfunction and its mechanisms is obscure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbi.2019.08.004DOI Listing
November 2019
3 Reads

Mitigation of Muscle Loss in Stressed Physiology: Military Relevance.

Nutrients 2019 Jul 24;11(8). Epub 2019 Jul 24.

Department of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Military personnel may be exposed to circumstances (e.g., large energy deficits, sleep deprivation, cognitive demands, and environmental extremes) of external stressors during training and combat operations (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11081703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724061PMC
July 2019
1 Read

Interleukin-1 receptor accessory proteins are required for normal homeostatic responses to sleep deprivation.

J Appl Physiol (1985) 2019 09 11;127(3):770-780. Epub 2019 Jul 11.

Department Integrative Physiology and Neurobiology, College of Veterinary Medicine, Washington State University, Spokane, Washington.

Interleukin-1β (IL1) is a sleep regulatory substance. The IL1/IL1 type 1 receptor complex requires a receptor accessory protein (AcP) to signal. There are three isoforms of AcP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.00366.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766708PMC
September 2019
9 Reads

Sleep-Cognition Hypothesis In maritime Pilots, what is the effect of long-term work-related poor sleep on cognition and amyloid accumulation in healthy middle-aged maritime pilots: methodology of a case-control study.

BMJ Open 2019 06 27;9(6):e026992. Epub 2019 Jun 27.

Geriatric Medicine, Radboudumc, Nijmegen, The Netherlands.

Introduction: Evidence indicates a bidirectional relationship between poor sleep and Alzheimer's disease (AD). While AD may lead to disruption of normal sleep, poor sleep in itself may play a causal role in the development of AD by influencing the production and/or clearance of the amyloid-beta (Aβ) protein. This led to the hypothesis that extended periods (>10 years) of sleep loss could lead to Aβ accumulation with subsequent cognitive AD-related decline. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-026992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597630PMC
June 2019
4 Reads

Extended Sleep Maintains Endurance Performance Better than Normal or Restricted Sleep.

Med Sci Sports Exerc 2019 12;51(12):2516-2523

School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Burwood, Victoria, AUSTRALIA.

Purpose: The cumulative influence of sleep time on endurance performance remains unclear. This study examined the effects of three consecutive nights of both sleep extension (SE) and sleep restriction (SR) on endurance cycling performance.

Methods: Endurance cyclists/triathletes (n = 9) completed a counterbalanced crossover experiment with three conditions: SR, normal sleep (NS), and SE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1249/MSS.0000000000002071DOI Listing
December 2019
1 Read

Sleep deprivation worsened oral ulcers and delayed healing process in an experimental rat model.

Life Sci 2019 Sep 21;232:116594. Epub 2019 Jun 21.

Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. Electronic address:

Aims: Sleep deficiency has been reported to be associated with some oral health problems. Oral ulcers are very common lesions of the oral mucosa, which severely impact patients' quality of life. However, the association between sleep deficiency and the oral ulcer remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.116594DOI Listing
September 2019
13 Reads

Microglia-mediated synaptic pruning is impaired in sleep-deprived adolescent mice.

Neurobiol Dis 2019 10 21;130:104517. Epub 2019 Jun 21.

Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC; Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC; Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan, ROC. Electronic address:

The detrimental effects of sleep insufficiency have been extensively explored. However, only a few studies have addressed this issue in adolescents. In the present study, we examined and compared the effects of 72 h paradoxical sleep deprivation (SD) on adolescent (5 weeks old) and adult (~12 weeks old) mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2019.104517DOI Listing
October 2019
3 Reads

Sympathetic neural responsiveness to sleep deprivation in older adults: sex differences.

Am J Physiol Heart Circ Physiol 2019 08 31;317(2):H315-H322. Epub 2019 May 31.

Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan.

Our laboratory has previously reported that total sleep deprivation (TSD) modifies muscle sympathetic neural activity (MSNA) differently in young men and women. Because postmenopausal women are among the highest risk for hypertension, this study compares MSNA responses with TSD in older men and women. We hypothesized that TSD would alter MSNA in older adults, with greater sympathoexcitation in postmenopausal women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00232.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732487PMC
August 2019
7 Reads

Testosterone Recovery Profiles After Cessation of Androgen Deprivation Therapy for Prostate Cancer.

J Sex Med 2019 06 9;16(6):872-879. Epub 2019 May 9.

Sexual & Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, NY, NY USA. Electronic address:

Introduction: Androgen deprivation therapy (ADT) is frequently used in the treatment of prostate cancer worldwide. Variable testosterone (T) recovery profiles after ADT cessation have been cited.

Aim: To evaluate T recovery after cessation of ADT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2019.03.273DOI Listing
June 2019
1 Read

Sleep deprivation alters neutrophil functions and levels of Th1-related chemokines and CD4 T cells in the blood.

Sleep Breath 2019 Dec 30;23(4):1331-1339. Epub 2019 Apr 30.

Department of Human & Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box: 35, 123, Muscat, Oman.

Purpose: The state of knowledge about the effect of sleep deprivation on the immune system is scarce and conflicting. It would therefore be useful to investigate the consequences of sleep deprivation on the immune system. We have studied the effect of sleep deprivation on the changes in neutrophil functions, and the ex vivo proliferative pattern of CD4 T lymphocytes in relationship with blood cytokine and chemokine levels due to the crucial role of these cells in mounting potent immune responses. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11325-019-01851-1
Publisher Site
http://dx.doi.org/10.1007/s11325-019-01851-1DOI Listing
December 2019
19 Reads

Stress and autonomic response to sleep deprivation in medical residents: A comparative cross-sectional study.

PLoS One 2019 4;14(4):e0214858. Epub 2019 Apr 4.

Department of Personality and Psychological Assessment and Treatment, University of Deusto, Bilbao, Spain.

The aim of this study was to evaluate the stress suffered by medical residents as the result of being on call for 24 hours, from a multidimensional approach. Two groups of medical residents selected according to their work shift, participated in the study: one group (n = 40) was sleep-deprived after having been actively on-call for 24 hours, and another contrast group (n = 18) had performed a normal work day and were not sleep-deprived. All participants completed pre-post measures during a 24 h cycle. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214858PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448892PMC
January 2020
4 Reads

Sleep deprivation moderates neural processes associated with passive auditory capture.

Brain Cogn 2019 06 30;132:89-97. Epub 2019 Mar 30.

School of Psychology, University of Ottawa, Ottawa, Canada; Brain and Mind Institute, University of Ottawa, Ottawa, Canada.

Sleep loss has a major effect on cognitive tasks that are dependent on the maintenance of active sustained attention. This study examines the effects of sleep deprivation on automatic information processing, more specifically, its effect on processes leading to involuntary auditory attention capture by task-irrelevant auditory events. Two experiments were run. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bandc.2019.03.004DOI Listing
June 2019
4 Reads

Clinical and genetic spectrum of SCN2A-associated episodic ataxia.

Eur J Paediatr Neurol 2019 May 7;23(3):438-447. Epub 2019 Mar 7.

Pediatric Neurology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Institute for Molecular and Behavioral Neuroscience, Faculty of Medicine, University of Cologne, Cologne, Germany. Electronic address:

Background: Pathogenic variants in SCN2A are associated with various neurological disorders including epilepsy, autism spectrum disorder and intellectual disability. Few reports have recently described SCN2A-associated episodic ataxia (EA). Our study identifies its broader clinical and genetic spectrum, and describes pharmacological approaches. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10903798193000
Publisher Site
http://dx.doi.org/10.1016/j.ejpn.2019.03.001DOI Listing
May 2019
34 Reads

Can the Combination of Acute Alcohol Intake and One Night of Sleep Deprivation Affect Neuromuscular Performance in Healthy Male Adults? A Cross-over Randomized Controlled Trial.

J Strength Cond Res 2019 May;33(5):1244-1251

Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Rodrigues, R, Franke, RA, Teixeira, BC, Macedo, RCO, Diefenthaeler, F, Baroni, BM, and Vaz, MA. Can the combination of acute alcohol intake and one night of sleep deprivation affect neuromuscular performance in healthy male adults? A cross-over randomized controlled trial. J Strength Cond Res 33(5): 1244-1251, 2019-The aim of this work was to perform a cross-over study to compare isolated and combined effects of alcohol intake and sleep deprivation on neuromuscular responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1519/JSC.0000000000003124DOI Listing
May 2019
5 Reads

c-Fos expression in the limbic thalamus following thermoregulatory and wake-sleep changes in the rat.

Exp Brain Res 2019 Jun 18;237(6):1397-1407. Epub 2019 Mar 18.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Piazza di Porta San Donato, 2, 40126, Bologna, Italy.

A cellular degeneration of two thalamic nuclei belonging to the "limbic thalamus", i.e., the anteroventral (AV) and mediodorsal (MD) nuclei, has been shown in patients suffering from Fatal Familial Insomnia (FFI), a lethal prion disease characterized by autonomic activation and severe insomnia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00221-019-05521-2DOI Listing
June 2019
2 Reads

Effects of sleep restriction on metabolism-related parameters in healthy adults: A comprehensive review and meta-analysis of randomized controlled trials.

Sleep Med Rev 2019 06 10;45:18-30. Epub 2019 Feb 10.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

This review aimed to provide a comprehensive examination of the effect of sleep restriction on metabolism-related parameters by synthesizing the emerging, best evidence. A systematic search was conducted in six electronic databases from inception to January 2018. We identified 41 randomized controlled trials using sleep restriction intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.smrv.2019.02.002DOI Listing
June 2019
5 Reads
8.513 Impact Factor

Acute sleep loss induces signs of visual discomfort in young men.

J Sleep Res 2019 12 27;28(6):e12837. Epub 2019 Feb 27.

Department of Neuroscience, Uppsala University, Uppsala, Sweden.

Acute sleep loss influences visual processes in humans, such as recognizing facial emotions. However, to the best of our knowledge, no study till date has examined whether acute sleep loss alters visual comfort when looking at images. One image statistic that can be used to investigate the level of visual comfort experienced under visual encoding is the slope of the amplitude spectrum, also referred to as the slope constant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jsr.12837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900002PMC
December 2019

Timing Modulates the Effect of Sleep Loss on Glucose Homeostasis.

J Clin Endocrinol Metab 2019 07;104(7):2801-2808

Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.

Context: Chronobiological factors may modulate the impact of sleep loss on glucose homeostasis. However, these interactions have not been systematically assessed in humans.

Objective: To assess the effect of sleep loss during the late vs early night on glucose homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02636DOI Listing
July 2019
1 Read

Computational modeling and analysis of the impacts of sleep deprivation on glucose stimulated insulin secretion.

Biosystems 2019 May 18;179:1-14. Epub 2019 Feb 18.

Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad, Pakistan.

Circadian clock is an exquisite internal biological clock functioning in all living organisms. Lifestyle changes such as shift work or frequent travelling might result in malfunctioning of the central and consequently the peripheral clocks leading to different metabolic disorders. Disruptions in β cell clock have been found to be a potential reason behind β cell failure that makes a person prone towards developing type 2 diabetes (T2DM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biosystems.2019.02.005DOI Listing
May 2019
2 Reads

Insomnia Disorder and Behaviorally Induced Insufficient Sleep Syndrome: Prevalence and Relationship to Depression in College Students.

Behav Sleep Med 2020 Mar-Apr;18(2):275-286. Epub 2019 Feb 21.

Department of Psychology, Virginia Commonwealth University, Richmond, Virginia.

: College students are at increased risk for sleep disorders, including insomnia disorder and obtaining less than 6.5 hr of sleep per night by choice, or behaviorally induced insufficient sleep syndrome (BIISS). These disorders can have deleterious daytime consequences, including depression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15402002.2019.1578772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814500PMC
June 2020
1 Read
1.562 Impact Factor

Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness.

Sleep 2019 05;42(5)

Department of Life Sciences, University of Zürich/ETH Zürich, Winterthurerstrasse, Zürich, Switzerland.

Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep-wake cycle overall, except at the diurnal start of the lights-off period, when they remained sleepier. The amount of time spent in NREM sleep and in the wake state in mice with lesioned HA neurons was unchanged over 24 hr, but the sleep-wake cycle was more fragmented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/sleep/zsz031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519916PMC
May 2019
1 Read

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.

Science 2019 02 24;363(6429):880-884. Epub 2019 Jan 24.

Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of β-amyloid (Aβ) that accumulates in Alzheimer's disease (AD). Furthermore, chronic sleep deprivation (SD) increases Aβ plaques. However, tau, not Aβ, accumulation appears to drive AD neurodegeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aav2546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410369PMC
February 2019
9 Reads

Pilot Sleep in Long-Range and Ultra-Long-Range Commercial Flights.

Aerosp Med Hum Perform 2019 Feb;90(2):109-115

Despite the clear need for understanding how pilot sleep affects performance during long-range (LR; 12-16h) and ultra-long-range (ULR; 16+h) flights, the scientific literature on the effects of sleep loss and circadian desynchronization on pilots' sleep in commercial aviation is sparse. We assessed pilots' sleep timing, duration, and post-trip recovery on two LR and two ULR nonstop California to Australasia routes. Pilot's sleep/wake history was measured with actigraphy and verified by logbook across 8-9 d. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3357/AMHP.5117.2019DOI Listing
February 2019

Sleep restriction alters the temporal expression of major histocompatibility complex class II molecules in murine lymphoid tissues.

Behav Brain Res 2019 04 11;362:152-159. Epub 2019 Jan 11.

Department of Sciences, Faculty of Natural and Applied Sciences, Notre Dame University-Louaize, Zouk Mosbeh, Lebanon. Electronic address:

Inadequate sleep is a major health concern of modern societies in view of the increased morbidity and mortality rates from physiological disturbances, including compromised adaptive immune responses. Many studies investigated the effect sleep restriction (SR) on the normal immune response in terms of leukocyte number and circulating cytokine and T helper cell (Th) profiles, but none considered the major histocompatibility complex (MHC), namely class II molecules. As no information exists about the normal temporal expression of MHC class II, the present study aimed at understanding how SR affects the adaptive immune response via altering the 1) normal daily expression profile and 2) overall constitutive levels of murine MHC class II by leukocytes' isolates from spleen and axillary lymph nodes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbr.2019.01.019DOI Listing
April 2019
3 Reads

Chronic high-caloric diet accentuates age-induced sleep alterations in mice.

Behav Brain Res 2019 04 11;362:131-139. Epub 2019 Jan 11.

Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address:

Obesity and sleep disturbances comprise major health problems which are likely interrelated. Diet-induced obesity in young mice has been demonstrated to lead towards an altered sleep homeostasis. In the current study, we investigated the effect of chronic (12 weeks) high-caloric diet (HCD, 45% fat) consumption on sleep and the sleep electroencephalogram (EEG) in young and older mice (6-month-old, n = 9; 18-month-old, n = 8 and 24-month-old, n = 4) and compared with age-matched controls on normal chow (n = 11, n = 9 and n = 9 respectively). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbr.2019.01.017DOI Listing
April 2019
5 Reads

Effects of two nights partial sleep deprivation on an evening submaximal weightlifting performance; are 1 h powernaps useful on the day of competition?

Chronobiol Int 2019 03 10;36(3):407-426. Epub 2019 Jan 10.

a Research Institute for Sport and Exercise Sciences , Liverpool John Moores University , Liverpool , UK.

We have investigated the effects that sleep restriction (3-h sleep during two consecutive nights) have on an evening (17:00 h) submaximal weightlifting session; and whether this performance improves following a 1-h post-lunch powernap. Fifteen resistance-trained males participated in this study. Before the experimental protocol commenced, 1RM bench press and inclined leg press and normative habitual sleep were recorded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07420528.2018.1552702DOI Listing
March 2019
3 Reads

Impact of sleep restriction on metabolic outcomes induced by overfeeding: a randomized controlled trial in healthy individuals.

Am J Clin Nutr 2019 01;109(1):17-28

Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Background: Overconsumption of energy-dense foods and sleep restriction are both associated with the development of metabolic and cardiovascular diseases, but their combined effects remain poorly evaluated.

Objective: The aim of this study was to assess whether sleep restriction potentiates the effects of a short-term overfeeding on intrahepatocellular lipid (IHCL) concentrations and on glucose homeostasis.

Design: Ten healthy subjects were exposed to a 6-d overfeeding period (130% daily energy needs, with 15% extra energy as sucrose and 15% as fat), with normal sleep (8 h sleep opportunity time) or sleep restriction (4 h sleep opportunity time), according to a randomized, crossover design. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcn/nqy215DOI Listing
January 2019
4 Reads
6.770 Impact Factor

Overnight worsening of emotional distress indicates maladaptive sleep in insomnia.

Sleep 2019 04;42(4)

Department of Sleep and Cognition, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

Study Objectives: Mechanisms underlying the distress of hyperarousal in people with insomnia remain enigmatic. We investigated whether insomnia impedes the overnight adaptation to emotional distress.

Methods: We induced the distressful self-conscious emotion of shame four times across three consecutive days by exposing 64 participants to their often embarrassingly out-of-tune singing, recorded earlier during a Karaoke session. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/sleep/zsy268DOI Listing
April 2019
17 Reads

Effect of sleep restriction on somatosensory sensitivity including occlusal sensation in the orofacial area.

J Prosthodont Res 2019 Apr 14;63(2):193-198. Epub 2018 Dec 14.

Division of Oral Function and Rehabilitation, Department of Oral Health Science, Nihon University School of Dentistry at Matsudo, Matsudo, Japan.

Purpose: To investigate the effect of sleep restriction on somatosensory sensitivity related to occlusion.

Methods: Twelve healthy participants participated in an experimental voluntary total sleep restriction (SR) study. In a study design, they were invited to sleep as usual, normal sleep (NS) or to restrict their sleep for four nights. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpor.2018.11.005DOI Listing
April 2019
1 Read

Sleep Loss Disrupts Morning-to-Evening Differences in Human White Adipose Tissue Transcriptome.

J Clin Endocrinol Metab 2019 05;104(5):1687-1696

Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.

Context: Chronodisruption, as caused by such conditions as perturbations of 24-hour rhythms of physiology and behavior, may promote the development of metabolic diseases.

Objective: To assess the acute effects of sleep curtailment on circadian regulation (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-01663DOI Listing
May 2019
4 Reads

Disrupted Resting-State Functional Connectivity in Hippocampal Subregions After Sleep Deprivation.

Neuroscience 2019 02 7;398:37-54. Epub 2018 Dec 7.

Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China. Electronic address:

Previous studies have revealed that sleep deprivation (SD) alters hippocampal functional connectivity (FC). However, the effects of SD on the FC of hippocampal subregions are still unknown. In this study, we used a masked independent component analysis (mICA) to partition the hippocampus into several small regions and investigated the changes in the FC of each small region within the whole brain after 24 h of SD in 40 normal young subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2018.11.049DOI Listing
February 2019
7 Reads

Heart rate variability rebound following exposure to persistent and repetitive sleep restriction.

Sleep 2019 02;42(2)

Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA.

While it is well established that slow-wave sleep electroencephalography (EEG) rebounds following sleep deprivation, very little research has investigated autonomic nervous system recovery. We examined heart rate variability (HRV) and cardiovagal baroreflex sensitivity (BRS) during four blocks of repetitive sleep restriction and sequential nights of recovery sleep. Twenty-one healthy participants completed the 22-day in-hospital protocol. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/sleep/advance-article/doi/10.1093/s
Publisher Site
http://dx.doi.org/10.1093/sleep/zsy226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369727PMC
February 2019
34 Reads

Using emotion regulation strategies after sleep deprivation: ERP and behavioral findings.

Cogn Affect Behav Neurosci 2019 04;19(2):283-295

Department of Psychology, The University of Hong Kong, Hong Kong, China.

Sleep deprivation is suggested to impact emotion regulation, but few studies have directly examined it. This study investigated the influence of sleep deprivation on three commonly used emotion regulation strategies (distraction, reappraisal, suppression) in Gross's (1998) process model of emotion regulation. Young healthy adults were randomly assigned to a sleep deprivation group (SD; n = 26, 13 males, age = 20. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3758/s13415-018-00667-yDOI Listing
April 2019
26 Reads

Cyclic nature of the REM sleep-like state in the cuttlefish .

J Exp Biol 2019 01 8;222(Pt 1). Epub 2019 Jan 8.

Marine Biological Laboratory, Woods Hole, MA 02543, USA.

Sleep is a state of immobility characterized by three key criteria: an increased threshold of arousal, rapid reversal to an alert state and evidence of homeostatic 'rebound sleep' in which there is an increase in the time spent in this quiescent state following sleep deprivation. Common European cuttlefish, , show states of quiescence during which they meet the last two of these three criteria, yet also show spontaneous bursts of arm and eye movements that accompany rapid changes in chromatophore patterns in the skin. Here, we report that this rapid eye movement sleep-like (REMS-like) state is cyclic in nature. Read More

View Article

Download full-text PDF

Source
http://jeb.biologists.org/lookup/doi/10.1242/jeb.174862
Publisher Site
http://dx.doi.org/10.1242/jeb.174862DOI Listing
January 2019
27 Reads

Sleep Quality and Sleep Duration with CKD are Associated with Progression to ESKD.

Clin J Am Soc Nephrol 2018 12 15;13(12):1825-1832. Epub 2018 Nov 15.

Yaizu City Hospital, Yaizu, Shizuoka, Japan.

Background And Objectives: Shorter or longer sleep duration and poor sleep quality are risk factors for numerous cardio-metabolic diseases, cardiovascular disease, and mortality in subjects with normal kidney function. The association of sleep duration and sleep quality with health outcomes in patients with CKD remains uncertain.

Design, Setting, Participants, & Measurements: A 4-year prospective cohort study in 17 nephrology centers in Japan, the CKD Japan Cohort (CKD-JAC) Study, assessed an association of self-reported sleep duration and sleep quality, on the basis of the Pittsburgh Sleep Quality Index (PSQI) questionnaire, with incidence of ESKD in 1601 patients with eGFR 10-59 ml/min per 1. Read More

View Article

Download full-text PDF

Source
http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.01340118
Publisher Site
http://dx.doi.org/10.2215/CJN.01340118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302324PMC
December 2018
36 Reads