3,127 results match your criteria Normal Sleep EEG


Heart rate changes associated with rhythmic masticatory muscle activities and limb movements in sleep bruxers: Preliminary findings.

Cranio 2019 Feb 16:1-11. Epub 2019 Feb 16.

a Neurological Institute of Jiangxi Province and Department of Neurology , Jiangxi Provincial People's Hospital , Nanchang , PR China.

Objective: To investigate the relationship of rhythmic masticatory muscle activities (RMMAs) and limb movements (LMs) with heart rate (HR) acceleration.

Methods: The amplitude and duration of HR increases, the time to reach peak HR associated with RMMAs/LMs during sleep, duration of movement events, and their relationships with cortical arousal levels were determined in 9 sleep bruxers and 10 normal controls.

Results: A total of 48. Read More

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http://dx.doi.org/10.1080/08869634.2019.1578032DOI Listing
February 2019

Iron supplementation should be given in breath-holding spells regardless of anemia

Turk J Med Sci 2019 Feb 11;49(1):230-237. Epub 2019 Feb 11.

Background/aim: The purpose of this retrospective study was to determine the effectiveness of oral iron therapy in breath-holding spells and evaluation of electrocardiographical changes

Materials And Methods: Three hundred twelve children aged 1–48 months and diagnosed with breath-holding spells between January 2017 and April 2018 were included. Patients’ laboratory findings were compared with 100 patients who had one simple febrile seizure.

Results: Cyanotic breath-holding spells were diagnosed in 85. Read More

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http://dx.doi.org/10.3906/sag-1805-92DOI Listing
February 2019
1 Read

Age-related cortical signatures of human sleep electroencephalography.

Neurobiol Aging 2019 Jan 6;76:106-114. Epub 2019 Jan 6.

Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada; Department of Psychology, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

Accumulating evidence demonstrates a direct relationship between impaired neural integrity and disrupted sleep physiology in normal and pathological aging. However, previous work has focus almost exclusively on nonrapid eye movement sleep electroencephalography as a proxy of cortical integrity with aging. Whether this relationship holds true for rapid eye movement sleep electroencephalography is unknown. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.12.012DOI Listing
January 2019
1 Read

GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.

Pharm Biol 2019 Dec;57(1):65-73

d Department of Public Health Sciences , Graduate School , Seoul , Republic of Korea.

Context: γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter and it is well established that activation of GABA receptors favours sleep. l-Theanine, a naturally occurring amino acid first discovered in green tea, is a well-known anti-anxiety supplement with proven relaxation benefits.

Objective: This study investigated the potential synergistic sleep enhancement effect of GABA/l-theanine mixture. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1557698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437PMC
December 2019
4 Reads

[Sleep-wake cycle and experimental models of Panx1 mutations].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(12):61-64

Kharkhevich Institute of Information Transmission of the Russian Academy of Sciences, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia.

Aim: To test the hypothesis of a possible role of the Panx1 (pannexin-1) mutation in changing the sleep - wake cycle.

Material And Methods: Continuous 24 h recording of the EEG and movement activity in Panx1 knockout and wild type mice was performed.

Results And Conclusion: A significant increase in wake percentage at the expense of a decrease in slow-wave sleep was found in knockout mice as compared to the control ones. Read More

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http://dx.doi.org/10.17116/jnevro201811812161DOI Listing
January 2018

Atypical SREDA During Wakefulness, NREM and REM Sleep in a Young Teenager: A Diagnostic Challenge.

Clin EEG Neurosci 2019 Jan 23:1550059418824446. Epub 2019 Jan 23.

1 Section of Pediatric Epilepsy, Epilepsy Center, Department of Neurology, Cleveland Clinic, Cleveland, OH, USA.

Subclinical rhythmic electrographic discharges of adult (SREDA) is a rare variant considered to be normal in EEG. It consists of sharp-contoured or sinusoidal waveforms in the theta frequency range (usually 5-7 Hz), occurring in a widespread distribution, often maximal over the parietotemporal regions. SREDA is usually bilateral but could be unilateral (atypical SREDA). Read More

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http://dx.doi.org/10.1177/1550059418824446DOI Listing
January 2019
2 Reads

Chronic high-caloric diet accentuates age-induced sleep alterations in mice.

Behav Brain Res 2019 Apr 11;362:131-139. Epub 2019 Jan 11.

Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address:

Obesity and sleep disturbances comprise major health problems which are likely interrelated. Diet-induced obesity in young mice has been demonstrated to lead towards an altered sleep homeostasis. In the current study, we investigated the effect of chronic (12 weeks) high-caloric diet (HCD, 45% fat) consumption on sleep and the sleep electroencephalogram (EEG) in young and older mice (6-month-old, n = 9; 18-month-old, n = 8 and 24-month-old, n = 4) and compared with age-matched controls on normal chow (n = 11, n = 9 and n = 9 respectively). Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.017DOI Listing
April 2019
1 Read

Comprehensive Evaluation of Healthy Volunteers Using Multi-Modality Brain Injury Assessments: An Exploratory, Observational Study.

Front Neurol 2018 17;9:1030. Epub 2018 Dec 17.

Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, United States.

Even though mild traumatic brain injury is common and can result in persistent symptoms, traditional measurement tools can be insensitive in detecting functional deficits after injury. Some newer assessments do not have well-established norms, and little is known about how these measures perform over time or how cross-domain assessments correlate with one another. We conducted an exploratory study to measure the distribution, stability, and correlation of results from assessments used in mild traumatic brain injury in healthy, community-dwelling adults. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.01030
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http://dx.doi.org/10.3389/fneur.2018.01030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315163PMC
December 2018
5 Reads

Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease.

Sci Transl Med 2019 Jan;11(474)

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

In Alzheimer's disease (AD), deposition of insoluble amyloid-β (Aβ) is followed by intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic loss, brain atrophy, and cognitive impairment. By the time even the earliest clinical symptoms are detectable, Aβ accumulation is close to reaching its peak and neocortical tau pathology is frequently already present. The period in which AD pathology is accumulating in the absence of cognitive symptoms represents a clinically relevant time window for therapeutic intervention. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau6550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342564PMC
January 2019
1 Read

Value of combined video EEG and polysomnography in clinical management of children with epilepsy and daytime or nocturnal spells.

Seizure 2019 Feb 17;65:1-5. Epub 2018 Dec 17.

Dental School, Virginia Commonwealth University, United States.

Purpose: Sleep disorders are common in epilepsy. Additionally, events of staring, jerking, or nocturnal behaviors are common presentations in neurology or sleep practice. Moreover, sleepiness and nocturnal awakenings are common symptoms in children with epilepsy and differentiation form ongoing seizures and sleep disorders is needed. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.12.009DOI Listing
February 2019
3 Reads

Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography.

Sleep Med 2018 Nov 30. Epub 2018 Nov 30.

Division of Pulmonary, Critical Care and Sleep Medicine, Yale New Haven Medical Center, Yale School of Medicine, 20 York Street New Haven, CT, 06510, USA. Electronic address:

Objective: Apnea/hypopnea index (AHI), especially without arousal criteria, does not adequately risk stratify patients with mild obstructive sleep apnea (OSA). We describe and test scoring reliability of an event, Flow Limitation/Obstruction With recovery breath (FLOW), representing obstructive airflow disruptions using only pressure transducer and snore signals available without electroencephalography.

Methods: The following process was used (i) Development of FLOW event definition, (ii) Training period and definition refinement, and (iii) Reliability testing on 10 100-epoch polysomnography (PSG) samples and two 100-sample tests. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.11.014DOI Listing
November 2018
2 Reads

Individual spindle detection and analysis in high-density recordings across the night and in thalamic stroke.

Sci Rep 2018 Dec 14;8(1):17885. Epub 2018 Dec 14.

Department of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.

Sleep spindles are thalamocortical oscillations associated with several behavioural and clinical phenomena. In clinical populations, spindle activity has been shown to be reduced in schizophrenia, as well as after thalamic stroke. Automatic spindle detection algorithms present the only feasible way to systematically examine individual spindle characteristics. Read More

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http://dx.doi.org/10.1038/s41598-018-36327-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294746PMC
December 2018

The neurophysiological and neurochemical effects of alcohol on the brain are inconsistent with current evidence based models of sleepwalking.

Authors:
Mark R Pressman

Sleep Med Rev 2019 02 10;43:92-95. Epub 2018 Nov 10.

Sleep Medicine Services, Lankenau Medical Center, Wynnewood, PA, USA; Lankenau Institute for Medical Research, Wynnewood, PA, USA; Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; Charles Widger School of Law, Villanova University, Villanova, PA, USA. Electronic address:

The DSM-5 and ICSD-3 have removed alcohol from the list of potential triggers for sleepwalking due to the lack of empirical evidence. Recent imaging and EEG based studies of sleepwalking and confusional arousals have provided a more data-based method of examining if alcohol is compatible with what is known about the neurophysiology and neurochemistry of sleepwalking. These studies have demonstrated a deactivation of the frontal areas of the brain, while the cingulate or motor cortex remains active and characterized activation in the form of beta EEG. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10870792183012
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http://dx.doi.org/10.1016/j.smrv.2018.10.003DOI Listing
February 2019
17 Reads

Amplitude-Integrated Electroencephalography for Early Diagnosis and Prognostic Prediction of Hypoxic Encephalopathy in Preterm Infants.

Med Sci Monit 2018 Dec 5;24:8795-8802. Epub 2018 Dec 5.

Department of Child Health, Linyi Central Hospital, Linyi, Shandong, China (mainland).

BACKGROUND The aim of this study was to analyze amplitude-integrated electroencephalography (aEEG) in early diagnosis and prognosis of hypoxic encephalopathy (HE) in premature infants. MATERIAL AND METHODS Thirty-six premature infants with HE who were treated in Linyi Central Hospital were enrolled into the study group, while 40 premature infants without HE were assigned into the control group. aEEG was conducted within 6 h after delivery to compare aEEG continuity, mature sleep-wake cycle, and maximum and minimum voltage in the 2 groups. Read More

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http://dx.doi.org/10.12659/MSM.909330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290585PMC
December 2018

Complexity of Wake Electroencephalography Correlates With Slow Wave Activity After Sleep Onset.

Front Neurosci 2018 13;12:809. Epub 2018 Nov 13.

Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States.

Sleep electroencephalography (EEG) provides an opportunity to study sleep scientifically, whose chaotic, dynamic, complex, and dissipative nature implies that non-linear approaches could uncover some mechanism of sleep. Based on well-established complexity theories, one hypothesis in sleep medicine is that lower complexity of brain waves at pre-sleep state can facilitate sleep initiation and further improve sleep quality. However, this has never been studied with solid data. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2018.00809
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http://dx.doi.org/10.3389/fnins.2018.00809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243118PMC
November 2018
7 Reads

Detecting abnormal electroencephalograms using deep convolutional networks.

Clin Neurophysiol 2019 Jan 17;130(1):77-84. Epub 2018 Nov 17.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

Objectives: Electroencephalography (EEG) is a central part of the medical evaluation for patients with neurological disorders. Training an algorithm to label the EEG normal vs abnormal seems challenging, because of EEG heterogeneity and dependence of contextual factors, including age and sleep stage. Our objectives were to validate prior work on an independent data set suggesting that deep learning methods can discriminate between normal vs abnormal EEGs, to understand whether age and sleep stage information can improve discrimination, and to understand what factors lead to errors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457183134
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http://dx.doi.org/10.1016/j.clinph.2018.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309707PMC
January 2019
10 Reads

Heart rate variability rebound following exposure to persistent and repetitive sleep restriction.

Sleep 2019 Feb;42(2)

Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA.

While it is well established that slow-wave sleep electroencephalography (EEG) rebounds following sleep deprivation, very little research has investigated autonomic nervous system recovery. We examined heart rate variability (HRV) and cardiovagal baroreflex sensitivity (BRS) during four blocks of repetitive sleep restriction and sequential nights of recovery sleep. Twenty-one healthy participants completed the 22-day in-hospital protocol. Read More

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https://academic.oup.com/sleep/advance-article/doi/10.1093/s
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http://dx.doi.org/10.1093/sleep/zsy226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369727PMC
February 2019
7 Reads

Using emotion regulation strategies after sleep deprivation: ERP and behavioral findings.

Cogn Affect Behav Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Department of Psychology, The University of Hong Kong, Hong Kong, China.

Sleep deprivation is suggested to impact emotion regulation, but few studies have directly examined it. This study investigated the influence of sleep deprivation on three commonly used emotion regulation strategies (distraction, reappraisal, suppression) in Gross's (1998) process model of emotion regulation. Young healthy adults were randomly assigned to a sleep deprivation group (SD; n = 26, 13 males, age = 20. Read More

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http://dx.doi.org/10.3758/s13415-018-00667-yDOI Listing
November 2018
7 Reads

Brain age from the electroencephalogram of sleep.

Neurobiol Aging 2019 Feb 19;74:112-120. Epub 2018 Oct 19.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

The human electroencephalogram (EEG) of sleep undergoes profound changes with age. These changes can be conceptualized as "brain age (BA)," which can be compared to chronological age to reflect the degree of deviation from normal aging. Here, we develop an interpretable machine learning model to predict BA based on 2 large sleep EEG data sets: the Massachusetts General Hospital (MGH) sleep lab data set (N = 2532; ages 18-80); and the Sleep Heart Health Study (SHHS, N = 1974; ages 40-80). Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.016DOI Listing
February 2019
15 Reads

Analysis of Features Extracted from EEG Epochs by Discrete Wavelet Decomposition and Hilbert Transform for Sleep Apnea Detection.

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:287-290

Sleep apnea (SA) is one of the most common disorders manifesting during sleep and the electroencephalo-gram (EEG) belongs to these biomedical signals that change during apnea and hypopnea episodes. In recent years, a few publications reported approaches to the automatic classification of sleep apnea episodes based only on the EEG. The purpose of this work was to analyze statistical features extracted from the EEG epochs by combined discrete wavelet transform (DWT) and Hilbert transform (HT). Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512201DOI Listing
July 2018
1 Read

Association Between Positive Occipital Sharp Transients of Sleep and Lambda Waves.

Clin EEG Neurosci 2018 Nov 14:1550059418813020. Epub 2018 Nov 14.

1 University of South Florida, Tampa, FL, USA.

Positive occipital sharp transients of sleep (POSTS) and lambda waves have similar morphology and location. We studied a possible association between these 2 normal EEG patterns. We reviewed a series of consecutive unselected ambulatory EEGs during a 3-month period (October 16, 2017 to January 19, 2018) and identified records with POSTS and records with lambda waves. Read More

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http://dx.doi.org/10.1177/1550059418813020DOI Listing
November 2018
2 Reads

Machine-learning-derived sleep-wake staging from around-the-ear electroencephalogram outperforms manual scoring and actigraphy.

J Sleep Res 2018 Nov 13:e12786. Epub 2018 Nov 13.

Institute of Biomedical Engineering, University of Oxford, Oxford, UK.

Quantification of sleep is important for the diagnosis of sleep disorders and sleep research. However, the only widely accepted method to obtain sleep staging is by visual analysis of polysomnography (PSG), which is expensive and time consuming. Here, we investigate automated sleep scoring based on a low-cost, mobile electroencephalogram (EEG) platform consisting of a lightweight EEG amplifier combined with flex-printed cEEGrid electrodes placed around the ear, which can be implemented as a fully self-applicable sleep system. Read More

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http://dx.doi.org/10.1111/jsr.12786DOI Listing
November 2018
3 Reads
3.350 Impact Factor

Evoked Alpha Power is Reduced in Disconnected Consciousness During Sleep and Anesthesia.

Sci Rep 2018 Nov 9;8(1):16664. Epub 2018 Nov 9.

Department of Anesthesiology, University of Wisconsin, Madison, 53792, USA.

Sleep and anesthesia entail alterations in conscious experience. Conscious experience may be absent (unconsciousness) or take the form of dreaming, a state in which sensory stimuli are not incorporated into conscious experience (disconnected consciousness). Recent work has identified features of cortical activity that distinguish conscious from unconscious states; however, less is known about how cortical activity differs between disconnected states and normal wakefulness. Read More

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http://www.nature.com/articles/s41598-018-34957-9
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http://dx.doi.org/10.1038/s41598-018-34957-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226534PMC
November 2018
15 Reads

Electrographic spikes are common in wildtype mice.

Epilepsy Behav 2018 Dec 3;89:94-98. Epub 2018 Nov 3.

F.M. Kirby Neurobiology Center, Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States of America. Electronic address:

High-voltage rhythmic electroencephalographic (EEG) spikes have been recorded in wildtype (WT) rats during periods of light slow-wave sleep and passive wakefulness. The source of this activity is unclear but has been attributed to either an inherent form of absence epilepsy or a normal feature of rodent sleep EEG. In contrast, little is known about epileptiform spikes in WT mice. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.09.003DOI Listing
December 2018
2 Reads
2.260 Impact Factor

Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse.

PLoS One 2018 6;13(11):e0207031. Epub 2018 Nov 6.

Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America.

The neonatal brain undergoes rapid maturational changes that facilitate the normal development of the nervous system and also affect the pathological response to brain injury. Electroencephalography (EEG) and analysis of sleep-wake vigilance states provide important insights into the function of the normal and diseased immature brain. While developmental changes in EEG and vigilance states are well-described in people, less is known about the normal maturational properties of rodent EEG, including the emergence and evolution of sleep-awake vigilance states. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207031PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219806PMC
November 2018
10 Reads

Short "Infraslow" Activity (SISA) With Burst Suppression in Acute Anoxic Encephalopathy: A Rare, Specific Ominous Sign With Acute Posthypoxic Myoclonus or Acute Symptomatic Seizures.

J Clin Neurophysiol 2018 Nov;35(6):496-503

Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Slow wave with frequency <0.5 Hz are recorded in various situations such as normal sleep, epileptic seizures. However, its clinical significance has not been fully clarified. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000507DOI Listing
November 2018
10 Reads

Sleep-related hypermotor epilepsy and peri-ictal hypotension in a patient with syntaxin-1B mutation.

Epileptic Disord 2018 Oct;20(5):413-417

Epilepsy Center, University Hospitals Cleveland Medical Centre, Cleveland, USA, Center for SUDEP Research.

STX1B is a gene that encodes syntaxin-1B. STX1B mutations have recently been implicated in fever-associated epilepsy syndromes. However, these have not previously been reported in sleep-related hypermotor epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0996DOI Listing
October 2018
2 Reads

Thalamic inhibitory circuits and network activity development.

Brain Res 2019 Mar 23;1706:13-23. Epub 2018 Oct 23.

Department of Pharmacology and Physiology, and Institute for Neuroscience, George Washington University, 2300 Eye Street NW, Washington, DC 20037, USA. Electronic address:

Inhibitory circuits in thalamus and cortex shape the major activity patterns observed by electroencephalogram (EEG) in the adult brain. Their delayed maturation and circuit integration, relative to excitatory neurons, suggest inhibitory neuronal development could be responsible for the onset of mature thalamocortical activity. Indeed, the immature brain lacks many inhibition-dependent activity patterns, such as slow-waves, delta oscillations and sleep-spindles, and instead expresses other unique oscillatory activities in multiple species including humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993183053
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http://dx.doi.org/10.1016/j.brainres.2018.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363901PMC
March 2019
10 Reads

Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with focal epilepsy: A systematic review and meta-analysis.

Epilepsia 2018 Dec 21;59(12):2296-2304. Epub 2018 Oct 21.

Faculty of Medicine Claude Bernard, University of Lyon, Lyon, France.

Objective: Despite the increasing number of studies reporting results of stereo-electroencephalography (SEEG)-guided radiofrequency-thermocoagulation (SEEG-guided RF-TC) in the treatment of patients with drug-resistant focal epilepsy, the exact efficacy of this approach remains unclear. The seizure-freedom rate varies greatly across studies and the factors associated with efficacy have not been formally investigated.

Methods: All prospective or retrospective studies reporting efficacy and/or safety of SEEG-guided RF-TC in patients with drug-resistant focal epilepsy were included. Read More

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http://doi.wiley.com/10.1111/epi.14584
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http://dx.doi.org/10.1111/epi.14584DOI Listing
December 2018
9 Reads

Hippocampal theta power pressure builds over non-REM sleep and dissipates within REM sleep episodes.

Arch Ital Biol 2018 Sep;156(3):112-126

Department of Integrative Biology and Physiology, 610 Charles E Young Drive East, Los Angeles, CA 90095, USA - Email:

The theta rhythm during waking has been associated with voluntary motor activity and learning processes involving the hippocampus. Theta also occurs continuously during rapid eye movement (REM) sleep where it likely serves memory consolidation. Theta amplitude builds across wakefulness and is the best indicator of the homeostatic need for non-REM (NREM) sleep. Read More

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http://dx.doi.org/10.12871/00039829201833DOI Listing
September 2018
13 Reads

Nonlinear harmonic generation in the corticothalamic system.

J Theor Biol 2019 Jan 8;460:184-194. Epub 2018 Oct 8.

School of Physics, University of Sydney, New South Wales 2006, Australia; Center for Integrative Brain Function, The University of Sydney, New South Wales 2006, Australia.

Neural field theory of the corticothalamic system is applied to quantitatively analyze harmonic generation in normal sleep and wake states. The linear power spectrum is derived analytically via the transfer function and is then convolved with itself and other factors to calculate the nonlinear power spectrum analytically via a recent perturbation expansion. Analysis shows that strong spectral peaks generate a harmonic at twice the original frequency with peak power proportional to the square of that of the original peak. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00225193183048
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http://dx.doi.org/10.1016/j.jtbi.2018.10.013DOI Listing
January 2019
1 Read

Transient epileptic and global amnesia: Real-life differential diagnosis.

Epilepsy Behav 2018 Nov 5;88:205-211. Epub 2018 Oct 5.

Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, via Álvaro del Portillo, 21, 00128 Rome, Italy. Electronic address:

Objective: Transient epileptic amnesia (TEA) is an underestimated condition in emergency clinical setting, where most of transient amnesic episodes tend to be classified as transient global amnesia (TGA). We designed this study to evaluate the actual frequency of TEA in a real-life scenario and to highlight the features that can help clinicians distinguishing it from TGA.

Methods: We retrospectively collected clinical data of 83 patients who accessed our emergency ward for an abrupt onset of amnesic disorder, initially interpreted as TGA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183021
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http://dx.doi.org/10.1016/j.yebeh.2018.07.015DOI Listing
November 2018
19 Reads

EEG-Based Automatic Sleep Staging Using Ontology and Weighting Feature Analysis.

Comput Math Methods Med 2018 4;2018:6534041. Epub 2018 Sep 4.

School of Information Science and Engineering, Lanzhou University, Lanzhou, China.

Sleep staging is considered as an effective indicator for auxiliary diagnosis of sleep diseases and related psychiatric diseases, so it attracts a lot of attention from sleep researchers. Nevertheless, sleep staging based on visual inspection of tradition is subjective, time-consuming, and error-prone due to the large bulk of data which have to be processed. Therefore, automatic sleep staging is essential in order to solve these problems. Read More

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https://www.hindawi.com/journals/cmmm/2018/6534041/
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http://dx.doi.org/10.1155/2018/6534041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142786PMC
December 2018
6 Reads

Parasomnia versus epilepsy: An affair of the heart?

Neurophysiol Clin 2018 Oct 15;48(5):277-286. Epub 2018 Sep 15.

NeuroPain Team, Inserm U 1028/CNRS, UMR 5292, University of Lyon, Lyon Neuroscience Research Centre (CRNL), 69677 Bron, France.

Objective: Differential diagnosis between sleep-related epileptic seizures and NREM parasomnia remains challenging. Pathophysiological markers to differentiate both conditions are needed. Activation of autonomic system is present in arousal reactions and epileptic seizures. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.08.002DOI Listing
October 2018
4 Reads

Parallel Arousal Pathways in the Lateral Hypothalamus.

eNeuro 2018 Jul-Aug;5(4). Epub 2018 Aug 21.

Biosciences Division, Center for Neuroscience, SRI International, Menlo Park, CA 94025.

Until recently, hypocretin (Hcrt) neurons were the only known wake-promoting neuronal population in the lateral hypothalamus (LH), but subpopulations of inhibitory neurons in this area and glutamatergic neurons in the nearby supramammillary nucleus (SuM) have recently been found that also promote wakefulness. We performed chemogenetic excitation of LH neurons in mice and observed increased wakefulness that lasted more than 4 h without unusual behavior or EEG anomalies. The increased wakefulness was similar in the presence or absence of the dual orexin receptor blocker almorexant (ALM). Read More

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0228-18.2018
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http://dx.doi.org/10.1523/ENEURO.0228-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140123PMC
August 2018
13 Reads

Visual EEG reviewing times with SCORE EEG.

Clin Neurophysiol Pract 2018 31;3:59-64. Epub 2018 Mar 31.

Section for Clinical Neurophysiology, Department of Neurology, Haukeland University Hospital, 5021 Bergen, Norway.

Objective: Visual EEG analysis is the gold standard for clinical EEG interpretation and analysis, but there is no published data on how long it takes to review and report an EEG in clinical routine. Estimates of reporting times may inform workforce planning and automation initiatives for EEG. The SCORE standard has recently been adopted to standardize clinical EEG reporting, but concern has been expressed about the time spent reporting. Read More

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http://dx.doi.org/10.1016/j.cnp.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133912PMC

[Non-epileptic paroxysmal disorder in neonates].

Medicina (B Aires) 2018;78 Suppl 2:42-46

Instituto Materno Perinatal de Lima, Perú.

Non-epileptic paroxysmal disorders are frequent events in the neonate, generally transient. However, due to their intensity they can be confused as true epileptic seizures. The objective of this review is to update the concepts in relation to tremors, neonatal benign sleep myoclonus (MNBS) and hyperekplexia. Read More

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January 2018
7 Reads

State-Dependent Modulation of Visual Evoked Potentials in a Rodent Genetic Model of Electroencephalographic Instability.

Front Syst Neurosci 2018 15;12:36. Epub 2018 Aug 15.

Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, United States.

Despite normal sleep timing and duration, -deficient () mice exhibit electroencephalographic (EEG) characteristics of reduced arousal, including elevated slow wave (1-4 Hz) activity during wakefulness. Here we show that these mice exhibit state-dependent instability in the EEG. Intermittent surges in EEG power were found in mice during wakefulness and rapid eye movement sleep, most prominently in the beta (15-35 Hz) range compared to wild type () mice. Read More

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http://dx.doi.org/10.3389/fnsys.2018.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104170PMC
August 2018
1 Read

Quiet sleep detection in preterm infants using deep convolutional neural networks.

J Neural Eng 2018 Dec 22;15(6):066006. Epub 2018 Aug 22.

Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium. imec, Leuven, Belgium.

Objective: Neonates spend most of their time asleep. Sleep of preterm infants evolves rapidly throughout maturation and plays an important role in brain development. Since visual labelling of the sleep stages is a time consuming task, automated analysis of electroencephalography (EEG) to identify sleep stages is of great interest to clinicians. Read More

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http://dx.doi.org/10.1088/1741-2552/aadc1fDOI Listing
December 2018
18 Reads

Vigilance States: Central Neural Pathways, Neurotransmitters and Neurohormones.

Endocr Metab Immune Disord Drug Targets 2019 ;19(1):26-37

Interdisciplinary Department of Medicine-Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases. University of Bari "Aldo Moro", School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.

Background And Objective: The sleep-wake cycle is characterized by a circadian rhythm involving neurotransmitters and neurohormones that are released from brainstem nuclei and hypothalamus. The aim of this review is to analyze the role played by central neural pathways, neurotransmitters and neurohormones in the regulation of vigilance states.

Method: We analyzed the literature identifying relevant articles dealing with central neural pathways, neurotransmitters and neurohormones involved in the control of wakefulness and sleep. Read More

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http://dx.doi.org/10.2174/1871530318666180816115720DOI Listing
January 2019
15 Reads

SYT1-associated neurodevelopmental disorder: a case series.

Brain 2018 Sep;141(9):2576-2591

Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Wellcome Trust / MRC Building, Hills Road, Cambridge, UK.

Synaptotagmin 1 (SYT1) is a critical mediator of fast, synchronous, calcium-dependent neurotransmitter release and also modulates synaptic vesicle endocytosis. This paper describes 11 patients with de novo heterozygous missense mutations in SYT1. All mutations alter highly conserved residues, and cluster in two regions of the SYT1 C2B domain at positions Met303 (M303K), Asp304 (D304G), Asp366 (D366E), Ile368 (I368T) and Asn371 (N371K). Read More

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http://dx.doi.org/10.1093/brain/awy209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113648PMC
September 2018
22 Reads

Romaine Lettuce/Skullcap Mixture Improves Sleep Behavior in Vertebrate Models.

Biol Pharm Bull 2018 ;41(8):1269-1276

Department of Food Science and Technology, Seoul Women's University.

The aim of this study is to investigate the effects of romaine lettuce leaves extract (RE), skullcap root extract (SE) and their mixture on sleep behaviors in vertebrate models. HPLC analysis showed that RE contains lactucopicrin (0.02±0. Read More

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http://dx.doi.org/10.1248/bpb.b18-00267DOI Listing
October 2018
16 Reads

Nationwide survey in Japan endorsed diagnostic criteria of benign adult familial myoclonus epilepsy.

Seizure 2018 Oct 19;61:14-22. Epub 2018 Jul 19.

Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:

Purpose: Benign adult familial myoclonus epilepsy (BAFME) is an autosomal dominant disease representing tremulous myoclonus or cortical tremor and infrequent generalized seizures. We aimed to delineate detailed epidemiological backgrounds in patients with Japanese BAFME and to establish diagnostic criteria based on clinical and electrophysiological findings.

Methods: After a previous survey on the current nationwide state of myoclonus epilepsy of adults in Japan, we conducted this survey to delineate the clinical characteristics of Japanese BAFME patients, using a questionnaire to obtain details for individual patients. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.07.014DOI Listing
October 2018
1 Read

Using optimal combined moderators to define heterogeneity in neural responses to randomized conditions: Application to the effect of sleep loss on fear learning.

Neuroimage 2018 11 21;181:718-727. Epub 2018 Jul 21.

Department of Psychiatry, University of Pittsburgh, USA.

Comparing the neural outcomes of two randomized experimental groups is a primary aim of many functional neuroimaging studies. However, between-group effects can be obscured by heterogeneity in neural responses. Optimal Combined Moderator (OCM) approaches have previously been used to clarify heterogeneity in clinical outcomes following treatment randomization. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.07.051DOI Listing
November 2018

Sleep spindle and psychopathology characteristics of frequent nightmare recallers.

Sleep Med 2018 Oct 4;50:113-131. Epub 2017 Nov 4.

Dream & Nightmare Laboratory, Center for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Canada; Department of Psychiatry, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Idiopathic nightmares are a common disturbance of rapid eye movement sleep (REM) sleep, but studies of comorbid pathologies and sleep architecture suggest that non-REM (NREM) sleep is also affected. Sleep spindles are a NREM sleep characteristic associated with both pathophysiology and sleep-dependent memory consolidation, yet they have not been evaluated in frequent nightmare recallers. The morning naps of 38 participants with frequent idiopathic nightmares (mean age: 23. Read More

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http://dx.doi.org/10.1016/j.sleep.2017.10.003DOI Listing
October 2018
3 Reads

Small sharp spikes as EEG markers of mesiotemporal lobe epilepsy.

Clin Neurophysiol 2018 Sep 28;129(9):1796-1803. Epub 2018 Jun 28.

Department of Neurology, University of Chicago, USA.

Objective: Mesial temporal lobe epilepsy (mTLE) is the most common type of focal epilepsy, but often lacks scalp EEG correlates. We ask if hippocampal epileptiform discharges that are characteristic of mTLE are associated with small sharp spikes (SSS) recorded on scalp EEG. SSS are considered benign waveforms, so are not currently used as markers of epilepsy. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.06.011DOI Listing
September 2018
11 Reads

Can Chaotic Analysis of Electroencephalogram Aid the Diagnosis of Encephalopathy?

Neurol Res Int 2018 29;2018:8192820. Epub 2018 May 29.

Department of Neurology, SCTIMST, Thiruvananthapuram, Kerala, India.

Chaotic analysis is a relatively novel area in the study of physiological signals. Chaotic features of electroencephalogram have been analyzed in various disease states like epilepsy, Alzheimer's disease, sleep disorders, and depression. All these diseases have primary involvement of the brain. Read More

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http://dx.doi.org/10.1155/2018/8192820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996471PMC
May 2018
23 Reads