3,227 results match your criteria Normal Sleep EEG


Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.

J Autoimmun 2020 Apr 10:102462. Epub 2020 Apr 10.

Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, 91120, Israel. Electronic address:

Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoimmune antibodies. RESULTS: Studying 30 South Sudanese NS patients and a similar number of healthy subjects from the same geographical region, revealed autoimmune antibodies to 3 extracellular peptides of ionotropic glutamate receptors in NS patients: AMPA-GluR3B peptide antibodies (86%), NMDA-NR1 peptide antibodies (77%) and NMDA-NR2 peptide antibodies (87%) (in either 1:10, 1:100 or 1:1000 serum dilution). Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102462DOI Listing

Using Mobile Electroencephalography and Actigraphy to Diagnose Attention-Deficit/Hyperactivity Disorder: Case-Control Comparison Study.

JMIR Ment Health 2020 Jun 19;7(6):e12158. Epub 2020 Jun 19.

Department of Psychology, Zhejiang Normal University, Zhejiang, China.

Background: Children with attention-deficit/hyperactivity disorder (ADHD), a neurobehavioral disorder, display behaviors of inattention, hyperactivity, or impulsivity, which can affect their ability to learn and establish proper family and social relationships. Various tools are currently used by child and adolescent psychiatric clinics to diagnose, evaluate, and collect information and data. The tools allow professional physicians to assess if patients need further treatment, following a thorough and careful clinical diagnosis process. Read More

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http://dx.doi.org/10.2196/12158DOI Listing

Interpretation of the Intracranial Stereoelectroencephalography Signal.

Neurosurg Clin N Am 2020 Jul 25;31(3):421-433. Epub 2020 Apr 25.

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 429A Thier, Boston, MA 02114, USA. Electronic address:

The intracranial electroencephalogram (iEEG) is essential in decision making for epilepsy surgery. Although localization of epileptogenic brain regions by means of iEEG has been the gold standard for surgical decision-making for more than 70 years, established guidelines for what constitutes genuine iEEG epileptic activity and what is normal brain activity are not available. This review provides a summary of the current state of knowledge and understanding on normal iEEG entities and variants, the effects of sleep on regional and lobar iEEG, iEEG patterns of interictal and ictal epileptic activity and their relation to well-described epileptogenic pathologies and surgical outcome. Read More

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http://dx.doi.org/10.1016/j.nec.2020.03.007DOI Listing

Estimating daytime sleepiness with previous night EEG, EOG and EMG spectrograms in patients with suspected sleep apnea using a convolutional neural network.

Sleep 2020 May 27. Epub 2020 May 27.

Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.

A common symptom of obstructive sleep apnea (OSA) is excessive daytime sleepiness (EDS). The gold standard test for EDS is the multiple sleep latency test (MSLT). However, due to its high cost, MSLT is not routinely conducted for OSA patients and EDS is instead evaluated using sleep questionnaires. Read More

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http://dx.doi.org/10.1093/sleep/zsaa106DOI Listing

Electroclinical spectrum of childhood epilepsy secondary to neonatal hypoglycemic brain injury in a low resource setting: A 10-year experience.

Seizure 2020 Jul 20;79:90-94. Epub 2020 May 20.

Neurology Division, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India.

Purpose: Neonatal hypoglycemic brain injury (NHBI) is being increasingly recognized as an important cause of drug resistant childhood epilepsy in low resource settings. We report the electro-clinical spectrum of children with epilepsy secondary to NHBI.

Methods: This was a retrospective study of children enrolled in the Epilepsy Clinic from January 2009 to August 2019. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.05.010DOI Listing
July 2020
2.059 Impact Factor

Genetic/idiopathic generalized epilepsies: Not so good as that!

Rev Neurol (Paris) 2020 Jun 15;176(6):427-438. Epub 2020 May 15.

Epilepsy Unit, Hôpital Gui-de-Chauliac, 80, avenue Fliche, 34295 Montpellier cedex 05, France; Research Unit (URCMA : Unité de Recherche sur les Comportements et Mouvements Anormaux), Inserm, U661, 34000 Montpellier, France.

Genetic or idiopathic generalized epilepsies (IGEs) account for 15-20% of all epilepsies. These syndromes have always been considered as good prognosis forms of epilepsy over time; however, for some patients, there is a need to maintain antiseizure drugs (ASD) for a long-time. Drug resistance is not uncommon (7-15%). Read More

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http://dx.doi.org/10.1016/j.neurol.2020.03.018DOI Listing

The impact of sleep loss on sustained and transient attention: an EEG study.

PeerJ 2020 4;8:e8960. Epub 2020 May 4.

School of Psychology, University of New England, Armidale, NSW, Australia.

Sleep is one of our most important physiological functions that maintains physical and mental health. Two studies examined whether discrete areas of attention are equally affected by sleep loss. This was achieved using a repeated-measures within-subjects design, with two contrasting conditions: normal sleep and partial sleep restriction of 5-h. Read More

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http://dx.doi.org/10.7717/peerj.8960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204874PMC

EEG changes associated with subjective under- and overestimation of sleep duration.

Sleep 2020 May 15. Epub 2020 May 15.

Center for Investigation and Research on Sleep, Lausanne University Hospital (CHUV), Switzerland.

Feeling awake although sleep recordings indicate clear-cut sleep occurs sometimes in good sleepers and to an extreme degree in patients with so-called paradoxical insomnia. It is unknown what underlies sleep misperception, as standard polysomnographic (PSG) parameters are often normal in these cases. Here we asked whether regional spectral power changes could account for the mismatch between objective and subjective total sleep times (TST). Read More

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http://dx.doi.org/10.1093/sleep/zsaa094DOI Listing

Applying a data-driven approach to quantify EEG maturational deviations in preterms with normal and abnormal neurodevelopmental outcomes.

Sci Rep 2020 Apr 29;10(1):7288. Epub 2020 Apr 29.

Institute of Biomedical Engineering (IBME), Department of Engineering Science, University of Oxford, Oxford, United Kingdom.

Premature babies are subjected to environmental stresses that can affect brain maturation and cause abnormal neurodevelopmental outcome later in life. Better understanding this link is crucial to developing a clinical tool for early outcome estimation. We defined maturational trajectories between the Electroencephalography (EEG)-derived 'brain-age' and postmenstrual age (the age since the last menstrual cycle of the mother) from longitudinal recordings during the baby's stay in the Neonatal Intensive Care Unit. Read More

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http://dx.doi.org/10.1038/s41598-020-64211-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190650PMC

The Role of Polysomnography in Identifying Sleep Disorders in Children with Migraine.

J Med Life 2020 Jan-Mar;13(1):64-67

Clinical Neurosciences Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Migraine pathophysiology and sleep share common neural pathways, and there are clinical as well as paraclinical observations, which lead to the hypothesis of an association between migraine and sleep disorders. The objective of this study consisted of the evaluation of a possible correlation between migraine and sleep disorders in children, as reflected by sleep architecture and electroencephalographic patterns. Eighteen patients aged five to seventeen were recruited for the migraine group, and sixteen age-matched patients with no criteria for migraine or any underlying organic disorder, diagnosed with emotional disorders, were enrolled in the control group. Read More

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http://dx.doi.org/10.25122/jml-2020-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175440PMC

Discriminative Sleep Patterns of Alzheimer's Disease via Tensor Factorization.

AMIA Annu Symp Proc 2019 4;2019:542-551. Epub 2020 Mar 4.

University of Texas Health Science Center, Houston, Texas, USA.

Sleep change is commonly reported in Alzheimer's disease (AD) patients and their brain wave studies show decrease in dreaming and non-dreaming stages. Although sleep disturbance is generally considered as a consequence of AD, it might also be a risk factor of AD as new biological evidence shows. Leveraging the National Sleep Research Resource (NSRR), we built a unique cohort of 83 cases and 331 controls with clinical variables and electroencephalography (EEG) signals. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153114PMC

Reported and Recorded Sleepiness in Obesity and Depression.

Front Psychiatry 2020 2;11:200. Epub 2020 Apr 2.

Institute for Statistics, Ludwig-Maximilians-Universität München, München, Germany.

Background: Obesity and depression are both associated with changes in sleep/wake regulation, with potential implications for individualized treatment especially in comorbid individuals suffering from both. However, the associations between obesity, depression, and subjective, questionnaire-based and objective, EEG-based measurements of sleepiness used to assess disturbed sleep/wake regulation in clinical practice are not well known.

Objectives: The study investigates associations between sleep/wake regulation measures based on self-reported subjective questionnaires and EEG-derived measurements of sleep/wake regulation patterns with depression and obesity and how/whether depression and/or obesity affect associations between such self-reported subjective questionnaires and EEG-derived measurements. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144401PMC

Wake-Promoting and EEG Spectral Effects of Modafinil After Acute or Chronic Administration in the R6/2 Mouse Model of Huntington's Disease.

Neurotherapeutics 2020 Apr 15. Epub 2020 Apr 15.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK.

Huntington's disease (HD) is characterised by progressive symptoms including cognitive deficits and sleep/wake disturbances reflected in an abnormal electroencephalography (EEG). Modafinil, a wake-promoting and cognitive-enhancing drug, has been considered as a treatment for HD. We used HD (R6/2) mice to investigate the potential for using modafinil to treat sleep-wake disturbance in HD. Read More

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http://dx.doi.org/10.1007/s13311-020-00849-yDOI Listing

Difference in spectral power density of sleep EEG between patients with simple snoring and those with obstructive sleep apnoea.

Sci Rep 2020 Apr 9;10(1):6135. Epub 2020 Apr 9.

Department of Psychiatry, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.

Patients with simple snoring (SS) often complain of poor sleep quality despite a normal apnoea-hypopnoea index (AHI). We aimed to identify the difference in power spectral density of electroencephalography (EEG) between patients with SS and those with obstructive sleep apnoea (OSA). We compared the absolute power spectral density values of standard EEG frequency bands between the SS (n = 42) and OSA (n = 129) groups during the non-rapid eye movement (NREM) sleep period, after controlling for age and sex. Read More

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http://dx.doi.org/10.1038/s41598-020-62915-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145832PMC

Landau-Kleffner Syndrome: A Diagnostic Challenge.

Cureus 2020 Mar 5;12(3):e7182. Epub 2020 Mar 5.

Obstetrics and Gynecology, St. John's University, New York, USA.

The Landau-Kleffner syndrome (LKS), formerly known as acquired epileptic aphasia, is a rare syndrome that typically presents in early childhood with language regression and seizures. We report a case of LKS in an 7-year-old boy who presented with aggressive behavior, difficulty in maintaining posture, and language regression. Systemic examination, including neurological evaluation, was normal. Read More

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http://dx.doi.org/10.7759/cureus.7182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124882PMC

Dietary natural cocoa ameliorates disrupted circadian rhythms in locomotor activity and sleep-wake cycles in mice with chronic sleep disorders caused by psychophysiological stress.

Nutrition 2020 Jul - Aug;75-76:110751. Epub 2020 Feb 4.

Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.

Objectives: Cocoa contains many chemical compounds that affect the physiological functions of experimental animals and humans. The present study used a mouse model characterized by disrupted circadian rhythms of locomotor activity and sleep-wake cycles to determine whether natural cocoa improves chronic sleep disorders (CSDs) induced by psychophysiological stress.

Methods: Mice were fed a high-fat, high-sucrose diet supplemented with 2. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110751DOI Listing
February 2020

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.

Authors:
Paul M Thompson Neda Jahanshad Christopher R K Ching Lauren E Salminen Sophia I Thomopoulos Joanna Bright Bernhard T Baune Sara Bertolín Janita Bralten Willem B Bruin Robin Bülow Jian Chen Yann Chye Udo Dannlowski Carolien G F de Kovel Gary Donohoe Lisa T Eyler Stephen V Faraone Pauline Favre Courtney A Filippi Thomas Frodl Daniel Garijo Yolanda Gil Hans J Grabe Katrina L Grasby Tomas Hajek Laura K M Han Sean N Hatton Kevin Hilbert Tiffany C Ho Laurena Holleran Georg Homuth Norbert Hosten Josselin Houenou Iliyan Ivanov Tianye Jia Sinead Kelly Marieke Klein Jun Soo Kwon Max A Laansma Jeanne Leerssen Ulrike Lueken Abraham Nunes Joseph O' Neill Nils Opel Fabrizio Piras Federica Piras Merel C Postema Elena Pozzi Natalia Shatokhina Carles Soriano-Mas Gianfranco Spalletta Daqiang Sun Alexander Teumer Amanda K Tilot Leonardo Tozzi Celia van der Merwe Eus J W Van Someren Guido A van Wingen Henry Völzke Esther Walton Lei Wang Anderson M Winkler Katharina Wittfeld Margaret J Wright Je-Yeon Yun Guohao Zhang Yanli Zhang-James Bhim M Adhikari Ingrid Agartz Moji Aghajani André Aleman Robert R Althoff Andre Altmann Ole A Andreassen David A Baron Brenda L Bartnik-Olson Janna Marie Bas-Hoogendam Arielle R Baskin-Sommers Carrie E Bearden Laura A Berner Premika S W Boedhoe Rachel M Brouwer Jan K Buitelaar Karen Caeyenberghs Charlotte A M Cecil Ronald A Cohen James H Cole Patricia J Conrod Stephane A De Brito Sonja M C de Zwarte Emily L Dennis Sylvane Desrivieres Danai Dima Stefan Ehrlich Carrie Esopenko Graeme Fairchild Simon E Fisher Jean-Paul Fouche Clyde Francks Sophia Frangou Barbara Franke Hugh P Garavan David C Glahn Nynke A Groenewold Tiril P Gurholt Boris A Gutman Tim Hahn Ian H Harding Dennis Hernaus Derrek P Hibar Frank G Hillary Martine Hoogman Hilleke E Hulshoff Pol Maria Jalbrzikowski George A Karkashadze Eduard T Klapwijk Rebecca C Knickmeyer Peter Kochunov Inga K Koerte Xiang-Zhen Kong Sook-Lei Liew Alexander P Lin Mark W Logue Eileen Luders Fabio Macciardi Scott Mackey Andrew R Mayer Carrie R McDonald Agnes B McMahon Sarah E Medland Gemma Modinos Rajendra A Morey Sven C Mueller Pratik Mukherjee Leyla Namazova-Baranova Talia M Nir Alexander Olsen Peristera Paschou Daniel S Pine Fabrizio Pizzagalli Miguel E Rentería Jonathan D Rohrer Philipp G Sämann Lianne Schmaal Gunter Schumann Mark S Shiroishi Sanjay M Sisodiya Dirk J A Smit Ida E Sønderby Dan J Stein Jason L Stein Masoud Tahmasian David F Tate Jessica A Turner Odile A van den Heuvel Nic J A van der Wee Ysbrand D van der Werf Theo G M van Erp Neeltje E M van Haren Daan van Rooij Laura S van Velzen Ilya M Veer Dick J Veltman Julio E Villalon-Reina Henrik Walter Christopher D Whelan Elisabeth A Wilde Mojtaba Zarei Vladimir Zelman

Transl Psychiatry 2020 Mar 20;10(1):100. Epub 2020 Mar 20.

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i. Read More

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http://dx.doi.org/10.1038/s41398-020-0705-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083923PMC
March 2020
4.360 Impact Factor

Expanding the clinical and EEG spectrum of CNKSR2-related encephalopathy with status epilepticus during slow sleep (ESES).

Clin Neurophysiol 2020 May 13;131(5):1030-1039. Epub 2020 Feb 13.

Danish Epilepsy Centre, Dianalund, Denmark; University of Copenhagen, Copenhagen, Denmark. Electronic address:

Objective: To investigate the clinical and EEG features of Encephalopathy with Status Epilepticus during slow Sleep (ESES) related to CNKSR2 pathogenic variants.

Methods: Detailed clinical history, repeated wakefulness/overnight sleep EEGs, brain MRI were collected in five patients, including one female, with CNKSR2-related ESES.

Results: Neurodevelopment in infancy was normal in two patients, delayed in three. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.01.020DOI Listing

The Inconsistent Nature of Heart Rate Variability During Sleep in Normal Children and Adolescents.

Front Cardiovasc Med 2020 21;7:19. Epub 2020 Feb 21.

Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, Adelaide, SA, Australia.

Cardiac function is modulated by multiple factors including exogenous (circadian rhythm) and endogenous (ultradian 90-110 min sleep cycle) factors. By evaluating heart rate variability (HRV) during sleep, we will better understand their influence on cardiac activity. The aim of this study was to evaluate HRV in the dark phase of the circadian rhythm during sleep in healthy children and adolescents. Read More

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http://dx.doi.org/10.3389/fcvm.2020.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046589PMC
February 2020

Content-Free Awareness: EEG-fcMRI Correlates of Consciousness in an Expert Meditator.

Front Psychol 2019 18;10:3064. Epub 2020 Feb 18.

Department of Psychosomatic Medicine and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.

The minimal neural correlate of the conscious state, regardless of the neural activity correlated with the ever-changing contents of experience, has still not been identified. Different attempts have been made, mainly by comparing the normal waking state to seemingly unconscious states, such as deep sleep or general anesthesia. A more direct approach would be the neuroscientific investigation of conscious states that are experienced as free of any specific phenomenal content. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.03064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040185PMC
February 2020

Peri- and Post-operative Amplitude-integrated Electroencephalography in Infants with Congenital Heart Disease.

Indian Pediatr 2020 02;57(2):133-137

Children's Heart Center, Guangdong Cardiovascular Institute; Guangzhou, Guangdong Province 510080, China.

Objective: To identify the factors influencing brain injury in infants with congenital heart disease (CHD) after cardiac surgery.

Methods: This retrospective study investigated 103 infants with CHD undergoing cardiac surgery between January 2013 and February 2016. Pre- and postoperative amplitude-integrated electroencephalography (aEEG) recordings were assessed for background pattern, sleep-wake cycle pattern and seizure activity. Read More

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February 2020

Clonidine Versus Chloral Hydrate for Recording Sleep EEG in Children.

Iran J Child Neurol 2020 ;14(1):85-92

Department of Pediatric Neurology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: One of the difficulties to conduct electroencephalography (EEG) in pediatric patient population is that they are not always cooperative during the procedure. Different medications are used to induce sedation during EEG recording. In order to find a medication with the least adverse effects and high efficacy, the current study aimed at comparing clonidine and chloral hydrate as a premedication prior to EEG recording in pediatric population. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956965PMC
January 2020

Examining the Utility of Resective Epilepsy Surgery in Children With Electrical Status Epilepticus in Sleep: Long Term Clinical and Electrophysiological Outcomes.

Front Neurol 2019 15;10:1397. Epub 2020 Jan 15.

Division of Pediatric Neurosurgery, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI, United States.

Electrical Status Epilepticus in Sleep (ESES) is an epileptic encephalopathy syndrome characterized by infrequent clinical seizures and prominent interictal burden during slow wave sleep associated with cognitive deficits and behavioral dysfunction. Medical treatment with anti-epileptic drugs is often unsuccessful. Resective surgery may be a valuable option in carefully selected patients. Read More

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http://dx.doi.org/10.3389/fneur.2019.01397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974623PMC
January 2020

Weakly encoded memories due to acute sleep restriction can be rescued after one night of recovery sleep.

Sci Rep 2020 Jan 29;10(1):1449. Epub 2020 Jan 29.

Laboratory of Functional Neuroscience, Pablo de Olavide University, Seville, 41013, Spain.

Sleep is thought to play a complementary role in human memory processing: sleep loss impairs the formation of new memories during the following awake period and, conversely, normal sleep promotes the strengthening of the already encoded memories. However, whether sleep can strengthen deteriorated memories caused by insufficient sleep remains unknown. Here, we showed that sleep restriction in a group of participants caused a reduction in the stability of EEG activity patterns across multiple encoding of the same event during awake, compared with a group of participants that got a full night's sleep. Read More

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http://dx.doi.org/10.1038/s41598-020-58496-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989495PMC
January 2020

Nighttime hypoxia affects global cognition, memory, and executive function in community-dwelling individuals with hypertension.

J Clin Sleep Med 2020 Feb 13;16(2):243-250. Epub 2020 Jan 13.

Neurovascular Research Laboratory, Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

Study Objectives: The objective of this study was to determine which respiratory and architectural sleep parameters are related to cognitive function and cognitive status (mild cognitive impairment [MCI] versus normal cognitive aging [NCA]) in community-dwelling individuals with hypertension. Additionally, it aimed to determine whether the results changed in the presence or absence of vascular brain lesions (silent brain infarcts and extensive white matter hyperintensities [WMHs]).

Methods: In a cohort of individuals with hypertension and without previous stroke or dementia, we conducted in-hospital polysomnography including electroencephalography, electro-oculography, electromyography, and magnetic resonance imaging to assess silent brain infarcts and WMHs. Read More

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http://dx.doi.org/10.5664/jcsm.8174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053040PMC
February 2020

Effectiveness of Sleep Apnea Detection Based on One vs. Two Symmetrical EEG Channels.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:4056-4059

Typically, two symmetrical EEG channels are recorded during polysomnography (PSG). As a rule, only the recommended channel is used for sleep stage scoring or sleep apnea detection, and the other for backup. Concurrently, there are many works demonstrating the asymmetry in brain activity. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856632DOI Listing

Excess brain age in the sleep electroencephalogram predicts reduced life expectancy.

Neurobiol Aging 2020 04 23;88:150-155. Epub 2019 Dec 23.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

The brain age index (BAI) measures the difference between an individual's apparent "brain age" (BA; estimated by comparing EEG features during sleep from an individual with age norms), and their chronological age (CA); that is BAI = BA-CA. Here, we evaluate whether BAI predicts life expectancy. Brain age was quantified using a previously published machine learning algorithm for a cohort of participants ≥40 years old who underwent an overnight sleep electroencephalogram (EEG) as part of the Sleep Heart Health Study (n = 4877). Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085452PMC

Chromatin remodeling dysfunction extends the etiological spectrum of schizophrenia: a case report.

BMC Med Genet 2020 01 8;21(1):10. Epub 2020 Jan 8.

Institut Neuromyogène, métabolisme énergétique et développement durable, CNRS UMR 5310, INSERM U1217, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.

Background: The role of deleterious copy number variations in schizophrenia is well established while data regarding pathogenic variations remain scarce. We report for the first time a case of schizophrenia in a child with a pathogenic mutation of the chromodomain helicase DNA binding protein 2 (CHD2) gene.

Case Presentation: The proband was the second child of unrelated parents. Read More

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http://dx.doi.org/10.1186/s12881-019-0946-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950831PMC
January 2020

Etiology and Clinical Impact of Interictal Periodic Discharges on the Routine Outpatient Scalp EEG.

J Clin Neurophysiol 2020 Jan 2. Epub 2020 Jan 2.

Neurosciences and Mental Health Department, Hospital de Santa Maria, CHLN, Lisbon, Portugal.

Purpose: Periodic discharges (PDs) are common in acute structural or metabolic brain lesions, but their occurrence during follow-up of epileptic patients in an outpatient setting is rare. Aim of this article was to study whether PDs on the routine outpatient scalp EEG of patients with epilepsy, as compared with nonperiodic epileptiform discharges, are associated with drug refractoriness and the decompensation of epilepsy and particular etiologies.

Methods: A retrospective case-control study. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000676DOI Listing
January 2020

Effect of music of specific frequency upon the sleep architecture and electroencephalographic pattern of individuals with delayed sleep latency: A daytime nap study.

J Family Med Prim Care 2019 Dec 10;8(12):3915-3919. Epub 2019 Dec 10.

Department of Physiology, AIIMS Patna, Bihar, India.

Introduction: Sleep is normal human behaviour. However, the stress in daily life leads to altered sleep behaviour like insomnia, parasomnia, etc. Owing to possible side effects, mind-body interventions like music, yoga and meditation could be a better alternative intervention to pharmacological interventions for the condition. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_575_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924256PMC
December 2019

Epileptogenicity in tuberous sclerosis complex: A stereoelectroencephalographic study.

Epilepsia 2020 01 20;61(1):81-95. Epub 2019 Dec 20.

National Institute of Health and Medical Research U1028/National Center for Scientific Research, Mixed Unit of Research 5292, Lyon Neuroscience Research Center, Lyon, France.

Objective: In tuberous sclerosis complex (TSC)-associated drug-resistant epilepsy, the optimal invasive electroencephalographic (EEG) and operative approach remains unclear. We examined the role of stereo-EEG in TSC and used stereo-EEG data to investigate tuber and surrounding cortex epileptogenicity.

Methods: We analyzed 18 patients with TSC who underwent stereo-EEG (seven adults). Read More

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http://dx.doi.org/10.1111/epi.16410DOI Listing
January 2020

Alzheimer's disease and sleep disturbances: a review.

Arq Neuropsiquiatr 2019 11;77(11):815-824

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Neurologia, Grupo de Neurologia Cognitiva e do Comportamento, São Paulo SP, Brasil.

The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This review describes the evolution of knowledge about the potential bidirectional relationships between AD and sleep disturbances exploring recent large prospective studies and meta-analyses and studies of the possible mechanisms through which sleep and the neurodegenerative process could be associated. Read More

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http://dx.doi.org/10.1590/0004-282X20190149DOI Listing
November 2019

Neurophysiological Findings and Brain Injury Pattern in Patients on ECMO.

Clin EEG Neurosci 2019 Dec 11:1550059419892757. Epub 2019 Dec 11.

Neurosciences Critical Care Division, Departments of Neurology, Anesthesiology and Critical Care Medicine and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Brain injury is a major determinant of outcomes in extracorporeal membrane oxygenation (ECMO). Neurologic prognostication in ECMO has not been established. Absent electroencephalogram (EEG) reactivity and absent N20 on somatosensory evoked potential (SSEP) are associated with poor outcome in other types of brain injuries, especially following cardiopulmonary arrest. Read More

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http://dx.doi.org/10.1177/1550059419892757DOI Listing
December 2019

Sleep staging algorithm based on multichannel data adding and multifeature screening.

Comput Methods Programs Biomed 2020 Apr 30;187:105253. Epub 2019 Nov 30.

Chengdu Techman Software Co.,Ltd, Chengdu, SC, China.

Background: Sleep staging is an important basis of sleep research, which is closely related to both normal sleep physiology and sleep disorders. Many studies have reported various sleep staging algorithms of which the framework generally consists of three parts: signal preprocessing, feature extraction and classification. However, there are few studies on the superposition of signals and feature screening for sleep staging. Read More

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http://dx.doi.org/10.1016/j.cmpb.2019.105253DOI Listing

How the Human Brain Sleeps: Direct Cortical Recordings of Normal Brain Activity.

Ann Neurol 2020 02 13;87(2):289-301. Epub 2019 Dec 13.

Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

Objective: Regional variations in oscillatory activity during human sleep remain unknown. Using the unique ability of intracranial electroencephalography to study in situ brain physiology, this study assesses regional variations of electroencephalographic sleep activity and creates the first atlas of human sleep using recordings from the first sleep cycle.

Methods: Intracerebral electroencephalographic recordings with channels displaying physiological activity from nonlesional tissue were selected from 91 patients of 3 tertiary epilepsy centers. Read More

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http://dx.doi.org/10.1002/ana.25651DOI Listing
February 2020

Developmental EEG hallmark or biological artifact? Glossokinetic artifact mimicking anterior slow dysrhythmia in two full term newborns.

Neurophysiol Clin 2019 Nov 15;49(5):377-380. Epub 2019 Nov 15.

Pediatric section, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

The aim of this paper is to describe an uncommon physiological EEG artifact in newborns caused by tongue movements (TM), mimicking anterior slow dysrhythmia (ASD). The subjects are two full-term newborns (39 weeks gestational age (GA)), admitted to the Neonatal Intensive Care Unit for respiratory distress. Both underwent polygraphic video-EEG recording in order to better characterize tremor-like movements of all four limbs that appeared 48 hours after birth. Read More

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http://dx.doi.org/10.1016/j.neucli.2019.07.015DOI Listing
November 2019

Alpha-wave Characteristics in Psychophysiological Insomnia.

J Med Signals Sens 2019 Oct-Dec;9(4):259-266. Epub 2019 Oct 24.

Sleep Disorders Research Center, Farabi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Individuals with psychophysiological insomnia (Psych-Insomnia) would show raised cortical arousal through their initiating sleep. Frequent changes in the alpha activity can be indicative of visual cortical activation, even without visual stimulation or retinal input. Therefore, we aimed to investigate alpha-wave characteristics in Psych-Insomnia before and after sleep onset. Read More

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http://dx.doi.org/10.4103/jmss.JMSS_51_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839435PMC
October 2019

Interictal epileptiform discharges on electroencephalography in children with methylenetetrahydrofolate reductase (MTHFR) polymorphisms.

Neurol Sci 2020 Mar 16;41(3):631-636. Epub 2019 Nov 16.

Department of Pediatric Metabolism, Faculty of Medicine, Mayıs University, Samsun, Turkey.

Objective: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism. MTHFR C677T and A1298C polymorphisms are best-defined variants of MTHFR that were reported to be associated with epilepsy development. The aim of the study was to determine the incidence of interictal epileptiform discharges on electroencephalography (EEG) in asymptomatic children with C677T and A1298C polymorphisms who had no history of seizure. Read More

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http://dx.doi.org/10.1007/s10072-019-04119-4DOI Listing

Contribution of the Retrotrapezoid Nucleus and Carotid Bodies to Hypercapnia- and Hypoxia-induced Arousal from Sleep.

J Neurosci 2019 12 22;39(49):9725-9737. Epub 2019 Oct 22.

Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.

The combination of hypoxia and hypercapnia during sleep produces arousal, which helps restore breathing and normalizes blood gases. Hypercapnia and hypoxia produce arousal in mammals by activating central (pH-sensitive) and peripheral (primarily O-sensitive) chemoreceptors. The relevant chemoreceptors and the neuronal circuits responsible for arousal are largely unknown. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1268-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891059PMC
December 2019

Daily Torpor and Sleep in a Non-human Primate, the Gray Mouse Lemur ().

Front Neuroanat 2019 24;13:87. Epub 2019 Sep 24.

UMR CNRS MNHN 7179 MECADEV, BioAdapt Team, Brunoy, France.

Daily torpor is an energy-saving process that evolved as an extension of non-rapid eye movement (NREM) sleep mechanisms. In many heterothermic species there is a relation between torpor expression and the repartition of the different behavioral states of sleep. Despite the presence of sleep during this period of hypothermia, torpor induces an accumulation of sleep debt which results in a rebound of sleep in mammals. Read More

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http://dx.doi.org/10.3389/fnana.2019.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768945PMC
September 2019
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Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex.

Neurobiol Dis 2020 02 9;134:104615. Epub 2019 Oct 9.

Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

Tuberous sclerosis complex (TSC) is a genetic disease related to hyperactivation of the mechanistic target of rapamycin (mTOR) pathway and manifested by neurological symptoms, such as epilepsy and sleep disorders. The pathophysiology of sleep dysfunction is poorly understood and is likely multifactorial, but may involve intrinsic biological regulators in the brain. Here, we characterized a mouse model of sleep disorders in TSC and investigated mechanisms of sleep dysfunction in this conditional knockout model involving inactivation of the Tsc1 gene in neurons and astrocytes (Tsc1CKO mice). Read More

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http://dx.doi.org/10.1016/j.nbd.2019.104615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980650PMC
February 2020
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5.078 Impact Factor

[Genetically determined epileptic encephalopathies].

Medicina (B Aires) 2019 ;79 Suppl 3:42-47

Servicio de Neurología Pediátrica, Departamento de Pediatría, Hospital Italiano de Buenos Aires, Argentina.

Epileptic encephalopathies is a group of epileptic syndromes characterized by progressive cognitive impairment beyond the expected for the epilepsy activity. They are characterized by severe pharmaco-resistant epilepsy, severely abnormal electroencephalograms, early-age onset, neurocognitve impairment, variable phenotype and usually normal brain MRI. These syndromes are usually genetically determined. Read More

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October 2019
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The prognostic value of sleep spindles in long-term outcome of West Syndrome.

Eur J Paediatr Neurol 2019 Nov 7;23(6):827-831. Epub 2019 Sep 7.

University Children's Hospital Muenster, General Pediatrics - Neuropediatric Department, University of Muenster, Muenster, Germany.

Objective: There is a high risk for a profound developmental disorder in West Syndrome. However, a prognostic biomarker for neurodevelopmental outcome does not exist. Hypsarrhythmia disturbs normal EEG sleep patterns and hence sleep spindles, which are thought to be important for memory consolidation and learning. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.09.003DOI Listing
November 2019

Electroencephalogram abnormalities in patients with NREM parasomnias.

Sleep Med 2019 May 28. Epub 2019 May 28.

Department of Pediatric Neurology, Erciyes University, Kayseri, Turkey.

Objective: Electroencephalographic (EEG) changes in patients with NREM parasomnias (NRP) occur in sleep architecture as changes in slow wave sleep or cyclic pattern, which are not considered abnormal. However, abnormalities in EEG in these patients have recently been reported, indicating that EEG patterns in NRPs are not definitive. Moreover, most of the polysomnography (PSG) findings in NRP patients were reported in the adult population requiring data from pediatric population to avoid bias in conclusion. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.05.009DOI Listing
May 2019
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Neonatal infant EEG bursts are altered by prenatal maternal depression and serotonin selective reuptake inhibitor use.

Clin Neurophysiol 2019 11 3;130(11):2019-2025. Epub 2019 Sep 3.

Columbia University Medical Center, Psychiatry, New York, NY 10032, USA.

Objective: Increasingly, serotonin selective reuptake inhibitor (SSRI) medications are prescribed in pregnancy. These medications pass freely into the developing fetus but little is known about their effect on brain development in humans. In this study we determine if prenatal maternal depression and SSRI medication change the EEG infant delta brush bursts which are an early marker of normal brain maturation. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944195PMC
November 2019
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Interictal epileptiform discharges shape large-scale intercortical communication.

Brain 2019 Nov;142(11):3502-3513

Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, USA.

Dynamic interactions between remote but functionally specialized brain regions enable complex information processing. This intercortical communication is disrupted in the neural networks of patients with focal epilepsy, and epileptic activity can exert widespread effects within the brain. Using large-scale human intracranial electroencephalography recordings, we show that interictal epileptiform discharges (IEDs) are significantly coupled with spindles in discrete, individualized brain regions outside of the epileptic network. Read More

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http://dx.doi.org/10.1093/brain/awz269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821283PMC
November 2019
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Aiginition Longitudinal Biomarker Investigation Of Neurodegeneration (ALBION): study design, cohort description, and preliminary data.

Postgrad Med 2019 Sep 16;131(7):501-508. Epub 2019 Sep 16.

1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School , Athens , Greece.

: Aiginition Longitudinal Biomarker Investigation Of Neurodegeneration (ALBION) is a longitudinal ongoing study initiated in 2018 that takes place in the Cognitive Disorders Clinic of Aiginition Hospital of the National and Kapodistrian University of Athens. Its aim is to address several research questions concerning the preclinical and prodromal stage of Alzheimer's disease and explore potential markers for early detection, prediction, and primary prevention of dementia. : We here present the design and the preliminary baseline characteristics of ALBION. Read More

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http://dx.doi.org/10.1080/00325481.2019.1663708DOI Listing
September 2019
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The Odds Ratio Product (An Objective Sleep Depth Measure): Normal Values, Repeatability, and Change With CPAP in Patients With OSA.

J Clin Sleep Med 2019 08;15(8):1155-1163

Cerebra Health Inc., Winnipeg, Canada.

Study Objectives: The Odds Ratio Product (ORP) is an objective measure of sleep depth using the relationships of the powers of different electroencephalogram (EEG) frequencies in a single index. The range of the ORP is 0 (deeply asleep) to 2.5 (fully awake). Read More

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http://dx.doi.org/10.5664/jcsm.7812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707046PMC
August 2019
4 Reads

Impaired visuospatial attention revealed by theta- and beta-band cortical activities in idiopathic REM sleep behavior disorder patients.

Clin Neurophysiol 2019 10 16;130(10):1962-1970. Epub 2019 Aug 16.

Department of Biomedical Engineering, College of Health Science, Yonsei University, Wonju, South Korea. Electronic address:

Objectives: Idiopathic REM sleep behavior disorder (iRBD) patients are susceptible to cognitive deficits, especially attention dysfunction. The objective of this study is to elucidate the neural mechanism of the dysfunction in attention known as 'inhibition of return' (IOR) in iRBD patients based on an analysis of oscillatory cortical activity during a selective attention task.

Methods: Event-related potentials (ERPs) were recorded from iRBD patients and normal control subjects while performing a Posner task. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.07.030DOI Listing
October 2019

Changes in topographic electroencephalogram during deepening levels of propofol sedation based on alertness/sedation scale under bispectral index guidance.

Anaesthesiol Intensive Ther 2019 ;51(3):224-229

Department of Clinical Neurophysiology, Tamayoz Clinic, Egypt.

Background: Sedation has been associated with numerous changes on electroencephalogram (EEG) but there is a need to clarify specific alterations in relation to deepening levels of sedation with different agents. We aimed to evaluate the effect of deepening levels of sedation induced by propofol and how they compare to natural sleep.

Methods: Fifty consecutive neurologically normal patients who underwent upper gastrointestinal endoscopy while sedated with propofol were included. Read More

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http://dx.doi.org/10.5114/ait.2019.87361DOI Listing
January 2019