3,110 results match your criteria Normal Sleep EEG


Individual spindle detection and analysis in high-density recordings across the night and in thalamic stroke.

Sci Rep 2018 Dec 14;8(1):17885. Epub 2018 Dec 14.

Department of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.

Sleep spindles are thalamocortical oscillations associated with several behavioural and clinical phenomena. In clinical populations, spindle activity has been shown to be reduced in schizophrenia, as well as after thalamic stroke. Automatic spindle detection algorithms present the only feasible way to systematically examine individual spindle characteristics. Read More

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http://dx.doi.org/10.1038/s41598-018-36327-xDOI Listing
December 2018

The neurophysiological and neurochemical effects of alcohol on the brain are inconsistent with current evidence based models of sleepwalking.

Authors:
Mark R Pressman

Sleep Med Rev 2018 Nov 10;43:92-95. Epub 2018 Nov 10.

Sleep Medicine Services, Lankenau Medical Center, Wynnewood, PA, USA; Lankenau Institute for Medical Research, Wynnewood, PA, USA; Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; Charles Widger School of Law, Villanova University, Villanova, PA, USA. Electronic address:

The DSM-5 and ICSD-3 have removed alcohol from the list of potential triggers for sleepwalking due to the lack of empirical evidence. Recent imaging and EEG based studies of sleepwalking and confusional arousals have provided a more data-based method of examining if alcohol is compatible with what is known about the neurophysiology and neurochemistry of sleepwalking. These studies have demonstrated a deactivation of the frontal areas of the brain, while the cingulate or motor cortex remains active and characterized activation in the form of beta EEG. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10870792183012
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http://dx.doi.org/10.1016/j.smrv.2018.10.003DOI Listing
November 2018
2 Reads

Amplitude-Integrated Electroencephalography for Early Diagnosis and Prognostic Prediction of Hypoxic Encephalopathy in Preterm Infants.

Med Sci Monit 2018 Dec 5;24:8795-8802. Epub 2018 Dec 5.

Department of Child Health, Linyi Central Hospital, Linyi, Shandong, China (mainland).

BACKGROUND The aim of this study was to analyze amplitude-integrated electroencephalography (aEEG) in early diagnosis and prognosis of hypoxic encephalopathy (HE) in premature infants. MATERIAL AND METHODS Thirty-six premature infants with HE who were treated in Linyi Central Hospital were enrolled into the study group, while 40 premature infants without HE were assigned into the control group. aEEG was conducted within 6 h after delivery to compare aEEG continuity, mature sleep-wake cycle, and maximum and minimum voltage in the 2 groups. Read More

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http://dx.doi.org/10.12659/MSM.909330DOI Listing
December 2018

Complexity of Wake Electroencephalography Correlates With Slow Wave Activity After Sleep Onset.

Front Neurosci 2018 13;12:809. Epub 2018 Nov 13.

Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States.

Sleep electroencephalography (EEG) provides an opportunity to study sleep scientifically, whose chaotic, dynamic, complex, and dissipative nature implies that non-linear approaches could uncover some mechanism of sleep. Based on well-established complexity theories, one hypothesis in sleep medicine is that lower complexity of brain waves at pre-sleep state can facilitate sleep initiation and further improve sleep quality. However, this has never been studied with solid data. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2018.00809
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http://dx.doi.org/10.3389/fnins.2018.00809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243118PMC
November 2018
2 Reads

Detecting abnormal electroencephalograms using deep convolutional networks.

Clin Neurophysiol 2018 Nov 17;130(1):77-84. Epub 2018 Nov 17.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

Objectives: Electroencephalography (EEG) is a central part of the medical evaluation for patients with neurological disorders. Training an algorithm to label the EEG normal vs abnormal seems challenging, because of EEG heterogeneity and dependence of contextual factors, including age and sleep stage. Our objectives were to validate prior work on an independent data set suggesting that deep learning methods can discriminate between normal vs abnormal EEGs, to understand whether age and sleep stage information can improve discrimination, and to understand what factors lead to errors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457183134
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http://dx.doi.org/10.1016/j.clinph.2018.10.012DOI Listing
November 2018
3 Reads

Heart Rate Variability Rebound Following Exposure to Persistent and Repetitive Sleep Restriction.

Sleep 2018 Nov 17. Epub 2018 Nov 17.

Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School.

While it is well established that slow wave sleep electroencephalography (EEG) rebounds following sleep deprivation, very little research has investigated autonomic nervous system recovery. We examined heart rate variability (HRV) and cardiovagal baroreflex sensitivity (BRS) during 4 blocks of repetitive sleep restriction and sequential nights of recovery sleep. Twenty-one healthy participants completed the 22-day in-hospital protocol. Read More

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https://academic.oup.com/sleep/advance-article/doi/10.1093/s
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http://dx.doi.org/10.1093/sleep/zsy226DOI Listing
November 2018
2 Reads

Using emotion regulation strategies after sleep deprivation: ERP and behavioral findings.

Cogn Affect Behav Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Department of Psychology, The University of Hong Kong, Hong Kong, China.

Sleep deprivation is suggested to impact emotion regulation, but few studies have directly examined it. This study investigated the influence of sleep deprivation on three commonly used emotion regulation strategies (distraction, reappraisal, suppression) in Gross's (1998) process model of emotion regulation. Young healthy adults were randomly assigned to a sleep deprivation group (SD; n = 26, 13 males, age = 20. Read More

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http://dx.doi.org/10.3758/s13415-018-00667-yDOI Listing
November 2018
2 Reads

Brain age from the electroencephalogram of sleep.

Neurobiol Aging 2018 Oct 19;74:112-120. Epub 2018 Oct 19.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

The human electroencephalogram (EEG) of sleep undergoes profound changes with age. These changes can be conceptualized as "brain age (BA)," which can be compared to chronological age to reflect the degree of deviation from normal aging. Here, we develop an interpretable machine learning model to predict BA based on 2 large sleep EEG data sets: the Massachusetts General Hospital (MGH) sleep lab data set (N = 2532; ages 18-80); and the Sleep Heart Health Study (SHHS, N = 1974; ages 40-80). Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.016DOI Listing
October 2018
7 Reads

Analysis of Features Extracted from EEG Epochs by Discrete Wavelet Decomposition and Hilbert Transform for Sleep Apnea Detection.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:287-290

Sleep apnea (SA) is one of the most common disorders manifesting during sleep and the electroencephalo-gram (EEG) belongs to these biomedical signals that change during apnea and hypopnea episodes. In recent years, a few publications reported approaches to the automatic classification of sleep apnea episodes based only on the EEG. The purpose of this work was to analyze statistical features extracted from the EEG epochs by combined discrete wavelet transform (DWT) and Hilbert transform (HT). Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512201DOI Listing
July 2018
1 Read

Association Between Positive Occipital Sharp Transients of Sleep and Lambda Waves.

Clin EEG Neurosci 2018 Nov 14:1550059418813020. Epub 2018 Nov 14.

1 University of South Florida, Tampa, FL, USA.

Positive occipital sharp transients of sleep (POSTS) and lambda waves have similar morphology and location. We studied a possible association between these 2 normal EEG patterns. We reviewed a series of consecutive unselected ambulatory EEGs during a 3-month period (October 16, 2017 to January 19, 2018) and identified records with POSTS and records with lambda waves. Read More

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http://dx.doi.org/10.1177/1550059418813020DOI Listing
November 2018
1 Read

Machine-learning-derived sleep-wake staging from around-the-ear electroencephalogram outperforms manual scoring and actigraphy.

J Sleep Res 2018 Nov 13:e12786. Epub 2018 Nov 13.

Institute of Biomedical Engineering, University of Oxford, Oxford, UK.

Quantification of sleep is important for the diagnosis of sleep disorders and sleep research. However, the only widely accepted method to obtain sleep staging is by visual analysis of polysomnography (PSG), which is expensive and time consuming. Here, we investigate automated sleep scoring based on a low-cost, mobile electroencephalogram (EEG) platform consisting of a lightweight EEG amplifier combined with flex-printed cEEGrid electrodes placed around the ear, which can be implemented as a fully self-applicable sleep system. Read More

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http://dx.doi.org/10.1111/jsr.12786DOI Listing
November 2018
2 Reads
3.350 Impact Factor

Evoked Alpha Power is Reduced in Disconnected Consciousness During Sleep and Anesthesia.

Sci Rep 2018 Nov 9;8(1):16664. Epub 2018 Nov 9.

Department of Anesthesiology, University of Wisconsin, Madison, 53792, USA.

Sleep and anesthesia entail alterations in conscious experience. Conscious experience may be absent (unconsciousness) or take the form of dreaming, a state in which sensory stimuli are not incorporated into conscious experience (disconnected consciousness). Recent work has identified features of cortical activity that distinguish conscious from unconscious states; however, less is known about how cortical activity differs between disconnected states and normal wakefulness. Read More

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http://www.nature.com/articles/s41598-018-34957-9
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http://dx.doi.org/10.1038/s41598-018-34957-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226534PMC
November 2018
8 Reads

Electrographic spikes are common in wildtype mice.

Epilepsy Behav 2018 Dec 3;89:94-98. Epub 2018 Nov 3.

F.M. Kirby Neurobiology Center, Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States of America. Electronic address:

High-voltage rhythmic electroencephalographic (EEG) spikes have been recorded in wildtype (WT) rats during periods of light slow-wave sleep and passive wakefulness. The source of this activity is unclear but has been attributed to either an inherent form of absence epilepsy or a normal feature of rodent sleep EEG. In contrast, little is known about epileptiform spikes in WT mice. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.09.003DOI Listing
December 2018
1 Read
2.260 Impact Factor

Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse.

PLoS One 2018 6;13(11):e0207031. Epub 2018 Nov 6.

Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America.

The neonatal brain undergoes rapid maturational changes that facilitate the normal development of the nervous system and also affect the pathological response to brain injury. Electroencephalography (EEG) and analysis of sleep-wake vigilance states provide important insights into the function of the normal and diseased immature brain. While developmental changes in EEG and vigilance states are well-described in people, less is known about the normal maturational properties of rodent EEG, including the emergence and evolution of sleep-awake vigilance states. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207031PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219806PMC
November 2018
5 Reads

Short "Infraslow" Activity (SISA) With Burst Suppression in Acute Anoxic Encephalopathy: A Rare, Specific Ominous Sign With Acute Posthypoxic Myoclonus or Acute Symptomatic Seizures.

J Clin Neurophysiol 2018 Nov;35(6):496-503

Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Slow wave with frequency <0.5 Hz are recorded in various situations such as normal sleep, epileptic seizures. However, its clinical significance has not been fully clarified. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000507DOI Listing
November 2018
5 Reads

Thalamic inhibitory circuits and network activity development.

Brain Res 2018 Oct 23. Epub 2018 Oct 23.

Department of Pharmacology and Physiology, and Institute for Neuroscience, George Washington University, 2300 Eye Street NW, Washington, DC 20037, USA. Electronic address:

Inhibitory circuits in thalamus and cortex shape the major activity patterns observed by electroencephalogram (EEG) in the adult brain. Their delayed maturation and circuit integration, relative to excitatory neurons, suggest inhibitory neuronal development could be responsible for the onset of mature thalamocortical activity. Indeed, the immature brain lacks many inhibition-dependent activity patterns, such as slow-waves, delta oscillations and sleep-spindles, and instead expresses other unique oscillatory activities in multiple species including humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993183053
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http://dx.doi.org/10.1016/j.brainres.2018.10.024DOI Listing
October 2018
4 Reads

Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with focal epilepsy: A systematic review and meta-analysis.

Epilepsia 2018 Dec 21;59(12):2296-2304. Epub 2018 Oct 21.

Faculty of Medicine Claude Bernard, University of Lyon, Lyon, France.

Objective: Despite the increasing number of studies reporting results of stereo-electroencephalography (SEEG)-guided radiofrequency-thermocoagulation (SEEG-guided RF-TC) in the treatment of patients with drug-resistant focal epilepsy, the exact efficacy of this approach remains unclear. The seizure-freedom rate varies greatly across studies and the factors associated with efficacy have not been formally investigated.

Methods: All prospective or retrospective studies reporting efficacy and/or safety of SEEG-guided RF-TC in patients with drug-resistant focal epilepsy were included. Read More

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http://doi.wiley.com/10.1111/epi.14584
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http://dx.doi.org/10.1111/epi.14584DOI Listing
December 2018
4 Reads

Nonlinear harmonic generation in the corticothalamic system.

J Theor Biol 2019 Jan 8;460:184-194. Epub 2018 Oct 8.

School of Physics, University of Sydney, New South Wales 2006, Australia; Center for Integrative Brain Function, The University of Sydney, New South Wales 2006, Australia.

Neural field theory of the corticothalamic system is applied to quantitatively analyze harmonic generation in normal sleep and wake states. The linear power spectrum is derived analytically via the transfer function and is then convolved with itself and other factors to calculate the nonlinear power spectrum analytically via a recent perturbation expansion. Analysis shows that strong spectral peaks generate a harmonic at twice the original frequency with peak power proportional to the square of that of the original peak. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00225193183048
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http://dx.doi.org/10.1016/j.jtbi.2018.10.013DOI Listing
January 2019
1 Read

Transient epileptic and global amnesia: Real-life differential diagnosis.

Epilepsy Behav 2018 Nov 5;88:205-211. Epub 2018 Oct 5.

Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, via Álvaro del Portillo, 21, 00128 Rome, Italy. Electronic address:

Objective: Transient epileptic amnesia (TEA) is an underestimated condition in emergency clinical setting, where most of transient amnesic episodes tend to be classified as transient global amnesia (TGA). We designed this study to evaluate the actual frequency of TEA in a real-life scenario and to highlight the features that can help clinicians distinguishing it from TGA.

Methods: We retrospectively collected clinical data of 83 patients who accessed our emergency ward for an abrupt onset of amnesic disorder, initially interpreted as TGA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183021
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http://dx.doi.org/10.1016/j.yebeh.2018.07.015DOI Listing
November 2018
13 Reads

EEG-Based Automatic Sleep Staging Using Ontology and Weighting Feature Analysis.

Comput Math Methods Med 2018 4;2018:6534041. Epub 2018 Sep 4.

School of Information Science and Engineering, Lanzhou University, Lanzhou, China.

Sleep staging is considered as an effective indicator for auxiliary diagnosis of sleep diseases and related psychiatric diseases, so it attracts a lot of attention from sleep researchers. Nevertheless, sleep staging based on visual inspection of tradition is subjective, time-consuming, and error-prone due to the large bulk of data which have to be processed. Therefore, automatic sleep staging is essential in order to solve these problems. Read More

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https://www.hindawi.com/journals/cmmm/2018/6534041/
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http://dx.doi.org/10.1155/2018/6534041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142786PMC
December 2018
6 Reads

Parasomnia versus epilepsy: An affair of the heart?

Neurophysiol Clin 2018 Oct 15;48(5):277-286. Epub 2018 Sep 15.

NeuroPain Team, Inserm U 1028/CNRS, UMR 5292, University of Lyon, Lyon Neuroscience Research Centre (CRNL), 69677 Bron, France.

Objective: Differential diagnosis between sleep-related epileptic seizures and NREM parasomnia remains challenging. Pathophysiological markers to differentiate both conditions are needed. Activation of autonomic system is present in arousal reactions and epileptic seizures. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.08.002DOI Listing
October 2018
1 Read

Parallel Arousal Pathways in the Lateral Hypothalamus.

eNeuro 2018 Jul-Aug;5(4). Epub 2018 Aug 21.

Biosciences Division, Center for Neuroscience, SRI International, Menlo Park, CA 94025.

Until recently, hypocretin (Hcrt) neurons were the only known wake-promoting neuronal population in the lateral hypothalamus (LH), but subpopulations of inhibitory neurons in this area and glutamatergic neurons in the nearby supramammillary nucleus (SuM) have recently been found that also promote wakefulness. We performed chemogenetic excitation of LH neurons in mice and observed increased wakefulness that lasted more than 4 h without unusual behavior or EEG anomalies. The increased wakefulness was similar in the presence or absence of the dual orexin receptor blocker almorexant (ALM). Read More

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0228-18.2018
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http://dx.doi.org/10.1523/ENEURO.0228-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140123PMC
August 2018
10 Reads

Visual EEG reviewing times with SCORE EEG.

Clin Neurophysiol Pract 2018 31;3:59-64. Epub 2018 Mar 31.

Section for Clinical Neurophysiology, Department of Neurology, Haukeland University Hospital, 5021 Bergen, Norway.

Objective: Visual EEG analysis is the gold standard for clinical EEG interpretation and analysis, but there is no published data on how long it takes to review and report an EEG in clinical routine. Estimates of reporting times may inform workforce planning and automation initiatives for EEG. The SCORE standard has recently been adopted to standardize clinical EEG reporting, but concern has been expressed about the time spent reporting. Read More

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http://dx.doi.org/10.1016/j.cnp.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133912PMC

[Non-epileptic paroxysmal disorder in neonates].

Medicina (B Aires) 2018 ;78 Suppl 2:42-46

Instituto Materno Perinatal de Lima, Perú.

Non-epileptic paroxysmal disorders are frequent events in the neonate, generally transient. However, due to their intensity they can be confused as true epileptic seizures. The objective of this review is to update the concepts in relation to tremors, neonatal benign sleep myoclonus (MNBS) and hyperekplexia. Read More

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January 2018
3 Reads

State-Dependent Modulation of Visual Evoked Potentials in a Rodent Genetic Model of Electroencephalographic Instability.

Front Syst Neurosci 2018 15;12:36. Epub 2018 Aug 15.

Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, United States.

Despite normal sleep timing and duration, -deficient () mice exhibit electroencephalographic (EEG) characteristics of reduced arousal, including elevated slow wave (1-4 Hz) activity during wakefulness. Here we show that these mice exhibit state-dependent instability in the EEG. Intermittent surges in EEG power were found in mice during wakefulness and rapid eye movement sleep, most prominently in the beta (15-35 Hz) range compared to wild type () mice. Read More

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http://dx.doi.org/10.3389/fnsys.2018.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104170PMC

Quiet sleep detection in preterm infants using deep convolutional neural networks.

J Neural Eng 2018 Dec 22;15(6):066006. Epub 2018 Aug 22.

Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium. imec, Leuven, Belgium.

Objective: Neonates spend most of their time asleep. Sleep of preterm infants evolves rapidly throughout maturation and plays an important role in brain development. Since visual labelling of the sleep stages is a time consuming task, automated analysis of electroencephalography (EEG) to identify sleep stages is of great interest to clinicians. Read More

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http://dx.doi.org/10.1088/1741-2552/aadc1fDOI Listing
December 2018
9 Reads

Vigilance States: Central Neural Pathways, Neurotransmitters And Neurohormone.

Endocr Metab Immune Disord Drug Targets 2018 Aug 15. Epub 2018 Aug 15.

Interdisciplinary Department of Medicine-Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases.University of Bari "Aldo Moro", School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari. Italy.

Bakground and objective: The sleep-wake cycle is characterized by a circadian rhythm involving neurotransmitters and neurohormones that are released from brainstem nuclei and hypothalamus. Aim of this review is to analyze the role played by central neural pathways, neurotrasmitters and neurohormones in the regulation of vigilance states.

Methods: We analyzed the literature identifying relevant articles dealing with central neural pathways, neurotrasmitters and neurohormones involved in the control of wakefulness and sleep. Read More

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http://dx.doi.org/10.2174/1871530318666180816115720DOI Listing
August 2018
9 Reads

SYT1-associated neurodevelopmental disorder: a case series.

Brain 2018 Sep;141(9):2576-2591

Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Wellcome Trust / MRC Building, Hills Road, Cambridge, UK.

Synaptotagmin 1 (SYT1) is a critical mediator of fast, synchronous, calcium-dependent neurotransmitter release and also modulates synaptic vesicle endocytosis. This paper describes 11 patients with de novo heterozygous missense mutations in SYT1. All mutations alter highly conserved residues, and cluster in two regions of the SYT1 C2B domain at positions Met303 (M303K), Asp304 (D304G), Asp366 (D366E), Ile368 (I368T) and Asn371 (N371K). Read More

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http://dx.doi.org/10.1093/brain/awy209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113648PMC
September 2018
19 Reads

Romaine Lettuce/Skullcap Mixture Improves Sleep Behavior in Vertebrate Models.

Biol Pharm Bull 2018 ;41(8):1269-1276

Department of Food Science and Technology, Seoul Women's University.

The aim of this study is to investigate the effects of romaine lettuce leaves extract (RE), skullcap root extract (SE) and their mixture on sleep behaviors in vertebrate models. HPLC analysis showed that RE contains lactucopicrin (0.02±0. Read More

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http://dx.doi.org/10.1248/bpb.b18-00267DOI Listing
October 2018
15 Reads

Nationwide survey in Japan endorsed diagnostic criteria of benign adult familial myoclonus epilepsy.

Seizure 2018 Oct 19;61:14-22. Epub 2018 Jul 19.

Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:

Purpose: Benign adult familial myoclonus epilepsy (BAFME) is an autosomal dominant disease representing tremulous myoclonus or cortical tremor and infrequent generalized seizures. We aimed to delineate detailed epidemiological backgrounds in patients with Japanese BAFME and to establish diagnostic criteria based on clinical and electrophysiological findings.

Methods: After a previous survey on the current nationwide state of myoclonus epilepsy of adults in Japan, we conducted this survey to delineate the clinical characteristics of Japanese BAFME patients, using a questionnaire to obtain details for individual patients. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.07.014DOI Listing
October 2018
1 Read

Sleep spindle and psychopathology characteristics of frequent nightmare recallers.

Sleep Med 2018 Oct 4;50:113-131. Epub 2017 Nov 4.

Dream & Nightmare Laboratory, Center for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Canada; Department of Psychiatry, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Idiopathic nightmares are a common disturbance of rapid eye movement sleep (REM) sleep, but studies of comorbid pathologies and sleep architecture suggest that non-REM (NREM) sleep is also affected. Sleep spindles are a NREM sleep characteristic associated with both pathophysiology and sleep-dependent memory consolidation, yet they have not been evaluated in frequent nightmare recallers. The morning naps of 38 participants with frequent idiopathic nightmares (mean age: 23. Read More

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http://dx.doi.org/10.1016/j.sleep.2017.10.003DOI Listing
October 2018
3 Reads

Small sharp spikes as EEG markers of mesiotemporal lobe epilepsy.

Clin Neurophysiol 2018 Sep 28;129(9):1796-1803. Epub 2018 Jun 28.

Department of Neurology, University of Chicago, USA.

Objective: Mesial temporal lobe epilepsy (mTLE) is the most common type of focal epilepsy, but often lacks scalp EEG correlates. We ask if hippocampal epileptiform discharges that are characteristic of mTLE are associated with small sharp spikes (SSS) recorded on scalp EEG. SSS are considered benign waveforms, so are not currently used as markers of epilepsy. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.06.011DOI Listing
September 2018
11 Reads

Can Chaotic Analysis of Electroencephalogram Aid the Diagnosis of Encephalopathy?

Neurol Res Int 2018 29;2018:8192820. Epub 2018 May 29.

Department of Neurology, SCTIMST, Thiruvananthapuram, Kerala, India.

Chaotic analysis is a relatively novel area in the study of physiological signals. Chaotic features of electroencephalogram have been analyzed in various disease states like epilepsy, Alzheimer's disease, sleep disorders, and depression. All these diseases have primary involvement of the brain. Read More

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http://dx.doi.org/10.1155/2018/8192820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996471PMC
May 2018
18 Reads

Childhood high-frequency EEG activity during sleep is associated with incident insomnia symptoms in adolescence.

J Child Psychol Psychiatry 2018 Jul 10. Epub 2018 Jul 10.

Sleep Research & Treatment Center, Department of Psychiatry, College of Medicine, Penn State Health Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA.

Background: Insomnia has been associated in cross-sectional studies with increased beta (15-35 Hz) electroencephalogram (EEG) power during nonrapid eye movement (NREM) sleep, an index of cortical hyperarousal. However, it is unknown whether this cortical hyperarousal is present before individuals with insomnia develop the disorder. To fill this gap, we examined the association of childhood sleep high-frequency EEG activity with incident insomnia symptoms (i. Read More

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http://doi.wiley.com/10.1111/jcpp.12945
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http://dx.doi.org/10.1111/jcpp.12945DOI Listing
July 2018
5 Reads

Increased cortical involvement and synchronization during CAP A1 slow waves.

Brain Struct Funct 2018 Nov 27;223(8):3531-3542. Epub 2018 Jun 27.

Oasi Research Institute-IRCCS, Via Conte Ruggero 73, 91018, Troina, Italy.

Slow waves recorded with EEG in NREM sleep are indicative of the strength and spatial extent of synchronized firing in neuronal assemblies of the cerebral cortex. Slow waves often appear in the A1 part of the cyclic alternating patterns (CAP), which correlate with a number of behavioral and biological parameters, but their physiological significance is not adequately known. We automatically detected slow waves from the scalp recordings of 37 healthy patients, visually identified CAP A1 events and compared slow waves during CAP A1 with those during NCAP. Read More

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http://dx.doi.org/10.1007/s00429-018-1703-4DOI Listing
November 2018
6 Reads

Hyperoxia enhances slow-wave forebrain states in urethane-anesthetized and naturally sleeping rats.

J Neurophysiol 2018 Oct 27;120(4):1505-1515. Epub 2018 Jun 27.

Neuroscience and Mental Health Institute, University of Alberta , Edmonton, Alberta , Canada.

Oxygen (O) is a crucial element for physiological functioning in mammals. In particular, brain function is critically dependent on a minimum amount of circulating blood levels of O and both immediate and lasting neural dysfunction can result following anoxic or hypoxic episodes. Although the effects of deficiencies in O levels on the brain have been reasonably well studied, less is known about the influence of elevated levels of O (hyperoxia) in inspired gas under atmospheric pressure. Read More

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http://dx.doi.org/10.1152/jn.00373.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230787PMC
October 2018
4 Reads

Instant sedative effect of acupuncture at GV20 on the frequency of electroencephalogram α and β waves in a model of sleep deprivation.

Exp Ther Med 2018 Jun 2;15(6):5353-5358. Epub 2018 May 2.

College of Acupuncture and Orthopaedics, Hubei University of Chinese Medicine/Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Wuhan, Hubei 430061, P.R. China.

Sleep deprivation (SD) adversely affects brain function and is accompanied by frequency-dependent changes in electroencephalograms (EEGs). Recent studies have suggested that acupuncture is an emerging alternative therapy for SD. However, the involvement of the frequency of EEG α and β waves in the protective effect of acupuncture against SD remains unknown. Read More

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http://dx.doi.org/10.3892/etm.2018.6123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994783PMC
June 2018
13 Reads

Polygonatum sibiricum rhizome promotes sleep by regulating non-rapid eye movement and GABAergic/serotonergic receptors in rodent models.

Biomed Pharmacother 2018 Sep 29;105:167-175. Epub 2018 May 29.

Department of Food Science and Technology, Seoul Women's University, Seoul 01797, Republic of Korea. Electronic address:

The aim of this study is to investigate the sleep-promoting effect of a water extract of the Polygonatum sibiricum rhizome (PSE) in rodent models. PSE contained oleamide (0.10 mg/g extract) and glyceryl monolinoleate (0. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.05.115DOI Listing
September 2018
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Profile of neuropsychological impairment in Sleep-related Hypermotor Epilepsy.

Sleep Med 2018 Aug 30;48:8-15. Epub 2018 Apr 30.

IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Objective: The aim of this study was to characterize the neuropsychological features of a representative sample of Sleep-related Hypermotor Epilepsy (SHE) patients and to highlight clinical associations.

Methods: This cross-sectional study included 60 consecutive patients with video/video-electroencephalography-documented SHE. All were assessed by measures of intelligence. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.03.027DOI Listing
August 2018
3 Reads

Myoclonic Jerks and Schizophreniform Syndrome: Case Report and Literature Review.

Front Psychiatry 2018 1;9:161. Epub 2018 May 1.

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Schizophreniform syndromes can be divided into primary idiopathic forms as well as different secondary organic subgroups (e.g., paraepileptic, epileptic, immunological, or degenerative). Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946012PMC
May 2018
4 Reads

[Sleep-wake rhythm after extracorporeal circulation in 
New Zealand rabbits].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Apr;43(4):434-440

Department of Anesthesiology, People's Hospital of Zhengzhou University, Zhengzhou 450003, China.

Objective: To evaluate the change of sleep-wake rhythm after extracorporeal circulation (ECC) in New Zealand rabbits, and to explore the role of clock genes in sleep-wake rhythm disorder by ECC.
 Methods: A total of 54 New Zealand rabbits were randomly divided into 3 groups: a normal group (Group N), a sham group (Group S) and a model group (Group ECC). Electrocorticogram (ECOG), electroophthalmogram (EOG) and electromyogram (EMG) were respectively recorded by multipurpose EEG recorder, and the sleep-wake rhythm was also recorded. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.04.016DOI Listing

Effects of a 20-Min Nap Post Normal and Jet Lag Conditions on P300 Components in Athletes.

Int J Sports Med 2018 Jul 14;39(7):508-516. Epub 2018 May 14.

UPFR Sports, 31, chemin de l'Epitaphe, 25030 Besançon, France.

Post-lunch sleepiness belongs to biological rhythms. Athletes take a nap to counteract afternoon circadian nadir, in prevision of disturbed sleep. This study examined the effects of brief post-lunch nap on vigilance in young and healthy athletes. Read More

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http://dx.doi.org/10.1055/a-0599-0888DOI Listing
July 2018
1 Read

Neurofeedback and the Neural Representation of Self: Lessons From Awake State and Sleep.

Front Hum Neurosci 2018 13;12:142. Epub 2018 Apr 13.

Laboratory for Human Brain Dynamics, AAI Scientific Cultural Services Ltd., Nicosia, Cyprus.

Neurofeedback has been around for half a century, but despite some promising results it is not yet widely appreciated. Recently, some of the concerns about neurofeedback have been addressed with functional magnetic resonance imaging and magnetoencephalography adding their contributions to the long history of neurofeedback with electroencephalography. Attempts to address other concerns related to methodological issues with new experiments and meta-analysis of earlier studies, have opened up new questions about its efficacy. Read More

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http://dx.doi.org/10.3389/fnhum.2018.00142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932408PMC
April 2018
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The prevalence of obstructive sleep apnea in patients with atrial fibrillation.

Clin Cardiol 2018 May 10;41(5):601-607. Epub 2018 May 10.

Department of Psychiatry, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario.

Background: Obstructive sleep apnea (OSA) is a systemic disorder associated with significant cardiovascular complications. OSA may play a role in the initiation and worsening of atrial fibrillation (AF). This study aimed to determine the prevalence and clinical predictors of OSA in patients with AF. Read More

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http://dx.doi.org/10.1002/clc.22933DOI Listing
May 2018
3 Reads

Juvenile Myoclonic Epilepsy Presenting with Neurocognitive Impairment: A Case Report.

Cureus 2018 Mar 5;10(3):e2271. Epub 2018 Mar 5.

Civil Hospital Karachi, Dow University of Health Sciences (DUHS), Karachi, Pakistan.

Juvenile myoclonic epilepsy (JME) is a genetically and clinically diverse disorder which is characterized by myoclonic jerks, usually after awakening from sleep. It affects both genders equally and manifests during the second decade of life. The various precipitating factors include stress, light, sleep deprivation, and alcohol. Read More

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http://dx.doi.org/10.7759/cureus.2271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935437PMC
March 2018
6 Reads

Genetic Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing Basal Forebrain Neurons in Behavioral State Control.

J Neurosci 2018 May 7;38(22):5168-5181. Epub 2018 May 7.

Department of Neurology, Beth Israel Deaconess Medical Center, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts 02115,

Recent studies have identified an especially important role for basal forebrain GABAergic (BF) neurons in the regulation of behavioral waking and fast cortical rhythms associated with cognition. However, BF neurons comprise several neurochemically and anatomically distinct subpopulations, including parvalbumin-containing BF neurons and somatostatin-containing BF neurons (BF neurons), and it was recently reported that optogenetic activation of BF neurons increases the probability of a wakefulness to non-rapid-eye movement (NREM) sleep transition when stimulated during the rest period of the animal. This finding was unexpected given that most BF neurons are not NREM sleep active and that central administration of the synthetic somatostatin analog, octreotide, suppresses NREM sleep or increases REM sleep. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2955-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977448PMC
May 2018
1 Read

Valerian/Cascade mixture promotes sleep by increasing non-rapid eye movement (NREM) in rodent model.

Biomed Pharmacother 2018 Mar 20;99:913-920. Epub 2018 Feb 20.

Department of Public Health Sciences, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

The aim of this study was to investigate the beneficial effect of Valerian/Cascade mixture on sleeping in mammal models. In pentobarbital-induced sleep model, Valerian, Cascade, and Valerian/Cascade mixture significantly reduced the latency time for sleeping, and total sleeping time effectively increased in these sample groups compared with the control. Valerian/Cascade mixture increased sleep duration by 37%. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.01.159DOI Listing
March 2018
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Visual evoked potentials are similar in polysomnographically defined quiet and active sleep in healthy newborns.

Int J Dev Neurosci 2018 Apr 23;68:26-34. Epub 2018 Apr 23.

Research Unit in Neurodevelopment, Institute of Neurobiology, National Autonomous University of Mexico, Querétaro, 76230, Mexico. Electronic address:

Morphology and late components of evoked potentials change depending on wake-sleep stages in adults. Visual Evoked potentials (VEPs) have been frequently studied in newborns to identify abnormal development of visual pathways; however, large variability has been reported and there is uncertainty as to the effect of sleep stages on VEPs in neonates.

Objective: To describe the characteristics of VEPs in one month old, healthy full-term newborns during active sleep (AS) and quiet sleep (QS), defined by simultaneous polysomnography (PSG). Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.04.007DOI Listing
April 2018
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Sleep EEG spectral power is correlated with subjective-objective discrepancy of sleep onset latency in major depressive disorder.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Jul 19;85:122-127. Epub 2018 Apr 19.

Departments of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.. Electronic address:

We aimed to identify the sleep electroencephalography (EEG) spectral power correlates of the subjective-objective discrepancy (SOD) of sleep onset latency (SOL) in major depressive disorder (MDD), primary insomnia (PI), and normal sleeping control (NSC) groups. We examined relative power values in standard frequency bands of the EEG spectra during the first Non-Rapid Eye Movement (NREM) sleep period as correlates of SOD of SOL between sleep diary and polysomnography in MDD (n = 36), PI (n = 19), and NSC (n = 23) groups. We also compared the relative spectral power of sleep EEG among MDD (n = 40), PI (n = 19), and NSC (n = 23) groups. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2018.04.010DOI Listing
July 2018
1 Read