3,369 results match your criteria Normal Sleep EEG


Brain dysfunction and thyroid antibodies: autoimmune diagnosis and misdiagnosis.

Brain Commun 2021 5;3(2):fcaa233. Epub 2021 Jan 5.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Hashimoto encephalopathy, also known as steroid-responsive encephalopathy associated with autoimmune thyroiditis, has been defined by sub-acute onset encephalopathy, with elevated thyroid antibodies, and immunotherapy responsiveness, in the absence of specific neural autoantibodies. We aimed to retrospectively review 144 cases referred with suspected Hashimoto encephalopathy over a 13-year period, and to determine the clinical utility of thyroid antibodies in the course of evaluation of those patients. One hundred and forty-four patients (all thyroid antibody positive) were included; 72% were women. Read More

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January 2021

Electroencephalography in Orthostatic Tremor: A Prospective Study of 30 Patients.

Tremor Other Hyperkinet Mov (N Y) 2021 May 21;11:18. Epub 2021 May 21.

Department of Neurological Sciences, University of Nebraska Medical Center, 988440 Nebraska Medical Center, Omaha, NE 68198-8440, US.

Background: Orthostatic tremor (OT) is characterized by a sensation of instability while standing, associated with high frequency (1318 Hz) tremor in the legs. Small retrospective series have reported electroencephalography (EEG) findings in OT with discordant results.

Methods: We prospectively enrolled 30 OT subjects. Read More

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Activation patterns of interictal epileptiform discharges in relation to sleep and seizures: An artificial intelligence driven data analysis.

Clin Neurophysiol 2021 Jul 8;132(7):1584-1592. Epub 2021 May 8.

Department of Neurology, Clinic Hietzing, Vienna, Austria; Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, Vienna, Austria; Medical Faculty, Sigmund Freud University, Vienna, Austria.

Objective: To quantify effects of sleep and seizures on the rate of interictal epileptiform discharges (IED) and to classify patients with epilepsy based on IED activation patterns.

Methods: We analyzed long-term EEGs from 76 patients with at least one recorded epileptic seizure during monitoring. IEDs were detected with an AI-based algorithm and validated by visual inspection. Read More

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Short-Term Impact of Sleep Apnea/Hypopnea on the Interaction Between Various Cortical Areas.

Clin EEG Neurosci 2021 Jul 14;52(4):296-306. Epub 2020 Oct 14.

School of Biomedical Engineering, 26469Sun Yat-Sen University, Guangzhou, China.

Introduction: Sleep apnea/hypopnea syndrome (SAHS) can change brain structure and function. These alterations are related to respiratory event-induced abnormal sleep, however, how brain activity changes during these events is less well understood.

Methods: To study information content and interaction among various cortical regions, we analyzed the variations of permutation entropy (PeEn) and symbolic transfer entropy (STE) of electroencephalography (EEG) activity during respiratory events. Read More

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Clinical Profile and Outcome of Indian Children with Aromatic L-Amino Acid Decarboxylase Deficiency: A primary CSF Neurotransmitter Disorder Mimicking as Dyskinetic Cerebral Palsy.

J Pediatr Genet 2021 Jun 27;10(2):85-91. Epub 2020 Jul 27.

Department of Pediatric Neurology, Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India.

Aromatic L-amino acid decarboxylase (AADC) deficiency is a disorder of neurotransmitter synthesis. It presents with psychomotor delay, dystonia, oculogyric crisis, and autonomic features. There is paucity of literature on this disorder. Read More

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Abnormally abrupt transitions from sleep-to-wake in Huntington's disease sheep (Ovis aries) are revealed by automated analysis of sleep/wake transition dynamics.

PLoS One 2021 13;16(5):e0251767. Epub 2021 May 13.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.

Sleep disturbance is a common and disruptive symptom of neurodegenerative diseases such as Alzheimer's and Huntington's disease (HD). In HD patients, sleep fragmentation appears at an early stage of disease, although features of the earliest sleep abnormalities in presymptomatic HD are not fully established. Here we used novel automated analysis of quantitative electroencephalography to study transitions between wake and non-rapid eye movement sleep in a sheep model of presymptomatic HD. Read More

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Characterization of pharmaco-EEG fingerprint and sleep-wake profiles of Lavandula angustifolia Mill. essential oil inhalation and diazepam administration in rats.

J Ethnopharmacol 2021 Aug 8;276:114193. Epub 2021 May 8.

Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; Biosignal Research Center for Health, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand. Electronic address:

Ethnopharmacological Relevance: Lavandula angustifolia Mill. Essential oil (Lavender EO) has a long history of medicinal use and is particularly claimed to possess anxiolytic and sedative properties. Lavender EO aromatherapy has been used to reduce distress and improve insomnia naturally. Read More

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Recovery of consciousness and cognition after general anesthesia in humans.

Elife 2021 05 10;10. Epub 2021 May 10.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

Understanding how the brain recovers from unconsciousness can inform neurobiological theories of consciousness and guide clinical investigation. To address this question, we conducted a multicenter study of 60 healthy humans, half of whom received general anesthesia for 3 hr and half of whom served as awake controls. We administered a battery of neurocognitive tests and recorded electroencephalography to assess cortical dynamics. Read More

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Photoplethysmography in Normal and Pathological Sleep.

Sensors (Basel) 2021 Apr 22;21(9). Epub 2021 Apr 22.

Department of Pulmonary Medicine, CHU Brugmann, Université Libre de Bruxelles (ULB), 1020 Brussels, Belgium.

This article presents an overview of the advancements that have been made in the use of photoplethysmography (PPG) for unobtrusive sleep studies. PPG is included in the quickly evolving and very popular landscape of wearables but has specific interesting properties, particularly the ability to capture the modulation of the autonomic nervous system during sleep. Recent advances have been made in PPG signal acquisition and processing, including coupling it with accelerometry in order to construct hypnograms in normal and pathologic sleep and also to detect sleep-disordered breathing (SDB). Read More

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Melatonin for an obese child with gene variant showing epilepsy and disordered sleep: A case report.

World J Clin Cases 2021 Apr;9(11):2688-2695

Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.

Background: Abnormalities in the () gene often lead to obesity, but are rarely associated with other conditions such as epilepsy and sleep disorder.

Case Summary: Here, we present a case of a male obese child with a heterozygous variant in (c.494G>A, p. Read More

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Prognostic Value of Amplitude Integrated Electroencephalography in Term Neonates With Encephalopathy.

Indian Pediatr 2021 Apr 17. Epub 2021 Apr 17.

Department of Neonatology, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

Objectives: To evaluate the prognostic value of amplitude-integrated EEG in term neonates with encephalopathy.

Methods: In this prospective observational study we enrolled 58 term neonates with encephalopathy from March, 2019 to March, 2020. Level of alertness was ascertained as per Volpe's classification and tone as per Amiel-Tison scale of tone assessment. Read More

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Temperature rhythms and ICU sleep: the TRIS study.

Minerva Anestesiol 2021 Apr 14. Epub 2021 Apr 14.

Thoracic Medicine Royal Brisbane and Women's Hospital, Herston, Australia.

Background: Core body temperature (CBT) patterns associated with sleep have not been described in the critically ill. This study aimed to characterise night-time sleep and its relationship to CBT in ICU patients.

Methods: A prospective study was performed in a 27-bed tertiary adult intensive care unit of 20 mechanically ventilated patients in the weaning stage of their critical illness. Read More

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Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease.

Neurobiol Dis 2021 Jul 10;155:105367. Epub 2021 Apr 10.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom. Electronic address:

Sleep disruption is a common invisible symptom of neurological dysfunction in Huntington's disease (HD) that takes an insidious toll on well-being of patients. Here we used electroencephalography (EEG) to examine sleep in 6 year old OVT73 transgenic sheep (Ovis aries) that we used as a presymptomatic model of HD. We hypothesized that despite the lack of overt symptoms of HD at this age, early alterations of the sleep-wake pattern and EEG powers may already be present. Read More

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Decreased P2 Waveform Reflects Impaired Brain Executive Function Induced by 12 h of Low Homeostatic Sleep Pressure: Evidence From an Event-Related Potential Study.

Front Neurosci 2021 24;15:599919. Epub 2021 Mar 24.

The Second Medical Center, Chinese PLA General Hospital, Beijing, China.

Homeostatic sleep pressure can cause cognitive impairment, in which executive function is the most affected. Previous studies have mainly focused on high homeostatic sleep pressure (long-term sleep deprivation); thus, there is still little related neuro-psycho-physiological evidence based on low homeostatic sleep pressure (12 h of continuous wakefulness) that affects executive function. This study aimed to investigate the impact of lower homeostatic sleep pressure on executive function. Read More

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A reliable interictal EEG grading scale for children with infantile spasms - The 2021 BASED score.

Epilepsy Res 2021 Jul 2;173:106631. Epub 2021 Apr 2.

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA. Electronic address:

Objective: To develop an improved interictal electroencephalogram (EEG) grading scale for children with infantile spasms founded on elements with adequate inter-rater reliability (IRR) to justify its further study for clinical and research purposes.

Methods: Three blinded reviewers assessed five-minute sleep epochs in 93 EEGs from 62 children (31 consecutive controls, 31 consecutive infantile spasms [pretreatment and posttreatment studies]) using a longitudinal bipolar montage. We determined the IRR of background amplitude, epileptiform discharges, >3 spike foci (including <50 % or >50 %), grouped multifocal spikes, paroxysmal voltage attenuations, and symmetry of sleep spindles. Read More

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Fermented Gamma Aminobutyric Acid Improves Sleep Behaviors in Fruit Flies and Rodent Models.

Int J Mol Sci 2021 Mar 29;22(7). Epub 2021 Mar 29.

Department of Food Nutrition, Sangmyung University, Seoul 03016, Korea.

The aim of this study was to investigate the effect of -fermented γ-aminobutyric acid (LB-GABA) on sleep behaviors in invertebrate and vertebrate models. In , LB-GABA-treated group showed an 8-9%-longer sleep duration than normal group did. LB-GABA-treated group also showed a 46. Read More

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Automatic Sleep-Stage Scoring in Healthy and Sleep Disorder Patients Using Optimal Wavelet Filter Bank Technique with EEG Signals.

Int J Environ Res Public Health 2021 03 17;18(6). Epub 2021 Mar 17.

School of Engineering, Ngee Ann Polytechnic, Singapore 599489, Singapore.

Sleep stage classification plays a pivotal role in effective diagnosis and treatment of sleep related disorders. Traditionally, sleep scoring is done manually by trained sleep scorers. The analysis of electroencephalogram (EEG) signals recorded during sleep by clinicians is tedious, time-consuming and prone to human errors. Read More

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Early Diagnosis of Brain Injury in Premature Infants Based on Amplitude-Integrated EEG Scoring System.

J Healthc Eng 2021 15;2021:6684818. Epub 2021 Mar 15.

Department of Neonatology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, China.

Analyzing and discussing the relationship between brain injury in preterm infants and related risk factors can provide evidence for perinatal prevention and early intervention of brain injury in preterm infants, thereby improving the quality of life of preterm infants. This paper selects term preterm infants diagnosed with preterm infant asphyxia in the NICU of a university's First Affiliated Hospital from January 2018 to February 2019 as the research object. In addition, healthy term infants born at the same time in the obstetric department of this hospital are selected as the control group. Read More

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Deep Learning in Automatic Sleep Staging With a Single Channel Electroencephalography.

Front Physiol 2021 3;12:628502. Epub 2021 Mar 3.

School of Science, China Pharmaceutical University, Nanjing, China.

This study centers on automatic sleep staging with a single channel electroencephalography (EEG), with some significant findings for sleep staging. In this study, we proposed a deep learning-based network by integrating attention mechanism and bidirectional long short-term memory neural network (AT-BiLSTM) to classify wakefulness, rapid eye movement (REM) sleep and non-REM (NREM) sleep stages N1, N2 and N3. The AT-BiLSTM network outperformed five other networks and achieved an accuracy of 83. Read More

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Aiding diagnosis of childhood attention-deficit/hyperactivity disorder of the inattentive presentation: Discriminant function analysis of multi-domain measures including EEG.

Biol Psychol 2021 04 17;161:108080. Epub 2021 Mar 17.

Peking University Sixth Hospital and Institute of Mental Health, Beijing, China; National Clinical Research Centre for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.

Introduction: We developed a neurocognitive assessment tool (NCAT) in consultation with mental health professionals working with children with AD/HD as a diagnostic aid and screening tool. This study examines the predictive utility of NCAT in the classification of children with AD/HD Inattentive presentation.

Method: Fifty three children with AD/HD Inattentive presentation and 161 typically-developing children completed an NCAT assessment. Read More

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Hippocampal sharp wave ripples during invasive monitoring: A physiologic finding.

Clin Neurophysiol 2021 May 24;132(5):1077-1079. Epub 2021 Feb 24.

Massachusetts General Hospital, Department of Neurology, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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Emulation of the BIS engine.

J Clin Monit Comput 2021 Mar 19. Epub 2021 Mar 19.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, CWN L1, Boston, MA, 02115, USA.

The operation of the BIS monitor remains undescribed, despite 20 years of clinical use and 3000 academic articles. The core algorithmic software (the BIS Engine) can be retrieved from the motherboard of the A-2000 monitor in binary form through forensic disassembly using debugging interfaces left in place by the original designers, opening the possibility of executing the BIS algorithms on contemporary computers through emulation. Three steps were required for emulation. Read More

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The Dual Orexin Receptor Antagonist DORA-22 Improves Mild Stress-induced Sleep Disruption During the Natural Sleep Phase of Nocturnal Rats.

Neuroscience 2021 05 15;463:30-44. Epub 2021 Mar 15.

Boston VA Research Institute, Inc., Boston, MA, United States; VA Boston Healthcare System, West Roxbury, MA, United States(1); Harvard Medical School, Department of Psychiatry, West Roxbury, MA, United States. Electronic address:

Dual orexinergic antagonists (DORAs) have been recently developed as a pharmacotherapy alternative to established hypnotics. Hypnotics are largely evaluated in preclinical rodent models in the dark/active period yet should be ideally evaluated in the light/inactive period, analogous to when sleep disruption occurs in humans. We describe here the hypnotic efficacy of DORA-22 in rodent models of sleep disturbance produced by cage changes in the light/inactive period. Read More

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Peripheral Lipopolyssacharide Rapidly Silences REM-Active LH Neurons.

Front Behav Neurosci 2021 25;15:649428. Epub 2021 Feb 25.

Stanford University School of Medicine, Stanford, CA, United States.

Immune factors (e.g., cytokines, chemokines) can alter the activity of neuronal circuits to promote "sickness behavior," a suite of adaptive actions that organisms exhibit in response to infection/injury in order to maximize their chances of recovery (i. Read More

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February 2021

Sonographic hypoechogenicity of brainstem raphe nucleus is correlated with electroencephalographic spike frequency in patients with epilepsy.

Epilepsy Behav 2021 04 11;117:107884. Epub 2021 Mar 11.

Department of Neurology, Epilepsy and Headache Group, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China. Electronic address:

Background: Brainstem raphe nucleus (BRN) hypoechogenicity in transcranial sonography (TCS) has been demonstrated in patients with major depression, possibly representing a sonographic manifestation of serotonergic dysfunction in depression. Most patients with epilepsy with comorbid depression exhibit hypoechogenic BRN in TCS. However, the role of BRN in the pathogenesis of epilepsy is unclear. Read More

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Classification of sleep apnea based on EEG sub-band signal characteristics.

Sci Rep 2021 Mar 12;11(1):5824. Epub 2021 Mar 12.

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, China.

Sleep apnea syndrome (SAS) is a disorder in which respiratory airflow frequently stops during sleep. Alterations in electroencephalogram (EEG) signal are one of the physiological changes that occur during apnea, and can be used to diagnose and monitor sleep apnea events. Herein, we proposed a method to automatically distinguish sleep apnea events using characteristics of EEG signals in order to categorize obstructive sleep apnea (OSA) events, central sleep apnea (CSA) events and normal breathing events. Read More

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Epileptic phenotype in late-onset hyperinsulinemic hypoglycemia successfully treated by diazoxide.

J Pediatr Endocrinol Metab 2021 May 4;34(5):667-673. Epub 2021 Mar 4.

Department of Pediatric Endocrinology, HFME, Hospices Civils de Lyon, Bron, France.

Objectives: Serious hyperinsulinemic hypoglycemia (HH) is generally the main initial symptom of hyperinsulinism. Epilepsy, without any overt feature of hypoglycemia, might be a very rare initial presentation of late-onset isolated hyperinsulinism.

Case Presentation: We describe a case of late-onset HH in a 15-year-old boy with a history of idiopathic generalized epilepsy, now named genetic generalized epilepsy (IGE/GGE), beginning with a tonic-clonic seizure at the age of 11 years. Read More

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Comparison of single-channel EEG, actigraphy, and sleep diary in cognitively normal and mildly impaired older adults.

Sleep Adv 2020 24;1(1):zpaa006. Epub 2020 Oct 24.

Department of Neurology, Washington University School of Medicine, St Louis, MO.

Study Objectives: Multiple methods for monitoring sleep-wake activity have identified sleep disturbances as risk factors for Alzheimer disease (AD). In order to identify the level of agreement between different methods, we compared sleep parameters derived from single-channel EEG (scEEG), actigraphy, and sleep diaries in cognitively normal and mildly impaired older adults.

Methods: Two hundred ninety-three participants were monitored at home for up to six nights with scEEG, actigraphy, and sleep diaries. Read More

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October 2020

A follow-up study in children with status epilepticus during sleep: From clinical spectrum to outcome.

Epilepsy Behav 2021 04 25;117:107843. Epub 2021 Feb 25.

Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, China. Electronic address:

Purpose: To evaluate the correlation between clinical spectrum and therapeutic outcomes and neuropsychological deficits in children with status epilepticus during sleep (SES).

Methods: The clinical spectrum of patients with SES was defined as follows: status epilepticus of benign childhood epilepsy with centro-temporal spikes (SEBECTs), atypical benign focal epilepsy during childhood (ABFEC), non-idiopathic focal epilepsy (NIFE), and Landau-Kleffner syndrome (LKS). SES cases were divided into 4 groups according to neuropsychological findings before treatment: developmental delay/intellectual disability (DD/ID), cognitive impairment (CI), attention deficit and/or hyperactivity behaviors (AHD), and normal group (NG). Read More

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