3,870 results match your criteria Normal Sleep EEG


Early-onset spontaneously relieved spasms of infancy in sleep: Electroclinical characteristics and differential diagnoses.

Brain Dev 2022 Jun 16. Epub 2022 Jun 16.

Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.

Purpose: Infantile spasm-like paroxysms are often difficult to classify as epileptic or non-epileptic. We aimed to study spontaneously relieved (non-epileptic) spasms of infancy in sleep. Elucidation of the electroclinical characteristics and differential diagnoses of such spasms could facilitate accurate diagnosis in the future. Read More

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An Investigation into the Correlation of Scalp Electrophysiological Findings with Preoperative Clinical and Imaging Findings in Patients with Focal Cortical Dysplasia.

Turk Neurosurg 2021 Dec 22. Epub 2021 Dec 22.

Istanbul University, Istanbul Faculty of Medicine, Departments of Neurology and Clinical Neurophysiology, Istanbul, Turkey.

Aim: In this study, patients who had epilepsy surgery and pathologically proven focal cortical dysplasia (FCD) were retrospectively evaluated to classify and discuss electroencephalography (EEG) findings in different pathological subtypes.

Material And Methods: This study included 19 refractory epilepsy patients who underwent surgery between 1999 and 2017 in the Istanbul Faculty of Medicine. Demographic data, preoperative examinations, scalp video EEGs, and postoperative outcomes were evaluated retrospectively. Read More

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December 2021

Minimal EEG channel selection for depression detection with connectivity features during sleep.

Comput Biol Med 2022 Jun 6;147:105690. Epub 2022 Jun 6.

School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, Sun Yat-sen University, China. Electronic address:

Background And Objectives: Sleeping cortical electroencephalogram (EEG) has the potential for depression detection, for different sleep structure and cortical connection have been proved in depressed patients. However, the operation of multi-channel sleep EEG recording is cumbersome and requires laboratory equipment and professional sleep technician. Here, we focus on the depression detection using minimal sleep EEG channels. Read More

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The Positive Effects of Extract on Quality of Sleep in Insomnia Rat Models.

Int J Environ Res Public Health 2022 May 29;19(11). Epub 2022 May 29.

Department of Physiology, College of Medicine, Catholic Kwandong University, Gangneung 25601, Korea.

Sleep disorders may have various causes and can incur mental and/or physical symptoms, and affect an individual's quality of life. In this study, we confirm that the extract (PCET) can improve sleep quality and structure by promoting inhibitory neurotransmission via the γ-aminobutyric acid (GABA) type A (GABA) receptors based on the mechanisms revealed in the experiment with superior cervical ganglion neurons. Pentobarbital-induced sleep tests were conducted in order to determine whether the PCET extract improves the sleep quality and structure in normal ICR mice. Read More

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Somatic genetics analysis of sleep in adult mice.

J Neurosci 2022 Jun 3. Epub 2022 Jun 3.

National Institute of Biological Sciences (NIBS), Beijing 102206, China

Classical forward and reverse mouse genetics require germline mutations and, thus, are unwieldy to study sleep functions of essential genes or redundant pathways. It is also time-consuming to conduct electroencephalogram/electromyogram-based mouse sleep screening owing to labor-intensive surgeries and genetic crosses. Here, we describe a highly accurate SleepV (video) system and adeno-associated virus (AAV)-based adult brain chimeric (ABC)-expression/knockout (KO) platform for somatic genetics analysis of sleep in adult male or female mice. Read More

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Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder.

J Neurodev Disord 2022 Jun 3;14(1):35. Epub 2022 Jun 3.

Department of Pediatrics, University of Toledo College of Medicine and Life Science, Toledo, OH, USA.

Background: Down syndrome regression disorder is a symptom cluster consisting of neuropsychiatric regression without cause. This study evaluated the incidence of neurodiagnostic abnormalities in individuals with Down syndrome regression disorder and determined if abnormalities are indicative of responses to therapeutic intervention.

Methods: A retrospective, multi-center, case-control study was performed. Read More

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Abnormal timing of slow wave synchronization processes in non-rapid eye movement sleep parasomnias.

Sleep 2022 May 24. Epub 2022 May 24.

Center for Investigation and Research on Sleep, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.

Study Objectives: Sleepwalking, confusional arousals, and sleep terrors are parasomnias occurring out of non-rapid eye movement (NREM) sleep. Several previous studies have described EEG changes associated with NREM parasomnia episodes, but it remains unclear whether these changes are specific to parasomnia episodes or whether they are part of the normal awakening process. Here we directly compared regional brain activity, measured with high-density (hd-) EEG, between parasomnia episodes and normal awakenings (without behavioral manifestations of parasomnia). Read More

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A circuit-level biomarker of Rett syndrome based on ectopic phase-amplitude coupling during slow-wave-sleep.

Cereb Cortex 2022 May 31. Epub 2022 May 31.

Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States.

Rett syndrome (RTT) is a neurodevelopmental disorder characterized by loss of purposeful hand use and spoken language following an initial period of normal development. Although much is known about the genetic and molecular underpinnings of RTT, less is known about the circuit-level etiopathology. Coupling of oscillations during slow-wave-sleep (SWS) underlies important neurocognitive processes in adulthood, yet its emergence has yet to be described in early typical development (TD) or in RTT. Read More

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A peculiar family with recurrent self-limited epileptic syndrome and associated developmental disorders in six girls.

Epilepsy Behav Rep 2022 22;19:100546. Epub 2022 Apr 22.

Pediatric Neurology and Epilepsy Unit, Department of Pediatrics, ARNAS Brotzu, Cagliari, Italy.

We describe a complex family with two couples (two sisters who married two brothers) with consistent social and neuropsychiatric problems, originally from Sardinia. Each couple had three daughters, which shared electroclinical epileptic syndrome and developmental disorders. All patients suffered from mild to moderate intellectual disability, speech difficulties and behavioural disorders. Read More

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Enhanced Laterality Index: A Novel Measure for Hemispheric Asymmetry.

J Healthc Eng 2022 29;2022:8997108. Epub 2022 Apr 29.

Science and Technology on Information Systems Engineering Laboratory, The 28th Research Institute of CETC, Nanjing 210000, China.

During sleep, the two hemispheres display asymmetries in their activation pattern. Various hemispheric asymmetry measures have been utilized in existing works. Nevertheless, all these measures have one common problem that they would merely take one representative quantity into account when evaluating the functional asymmetry. Read More

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Slow wave synchronization and sleep state transitions.

Sci Rep 2022 05 6;12(1):7467. Epub 2022 May 6.

Center for Dynamical Biomarkers, MA, 02067, Sharon, USA.

Spontaneous synchronization over large networks is ubiquitous in nature, ranging from inanimate to biological systems. In the human brain, neuronal synchronization and de-synchronization occur during sleep, with the greatest degree of neuronal synchronization during slow wave sleep (SWS). The current sleep classification schema is based on electroencephalography and provides common criteria for clinicians and researchers to describe stages of non-rapid eye movement (NREM) sleep as well as rapid eye movement (REM) sleep. Read More

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[Alternating Hemiplegia of Childhood associated with a pathogenic variant of the ATP1A3 gene].

Andes Pediatr 2022 Feb 30;93(1):117-122. Epub 2022 Mar 30.

Hospital Dr. Exequiel González Cortés, Santiago, Chile.

Introduction: Alternating hemiplegia of childhood (AHC), is a rare disease characterized by episodes of hemi/quadriplegia, dystonic postures, abnormal eye movements, and movement disorders. ATP1A3 gene mu tations are the most frequently associated with AHC.

Objective: To present a clinical case of AHC, where genetic study and the observation of home videos were of great diagnostic utility. Read More

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February 2022

Flos Extract Promotes Sleep in Sleep-Deprived and Lipopolysaccharide-Challenged Mice.

Front Neurosci 2022 12;16:848588. Epub 2022 Apr 12.

Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.

Flos (LJF) is commonly used in Chinese herbal medicines and exhibits anti-viral, anti-oxidative, and anti-inflammatory properties. The reciprocal relationship between sleep, the immune system and the central nervous system is well-established in the animal models. In this study, we used the mouse model to analyze the beneficial effects of the LJF on the dysregulated sleep-wakefulness cycle in response to acute sleep deprivation and lipopolysaccharide (LPS)-induced inflammation and the potential underlying mechanisms. Read More

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Evaluation of Heart Rate Variability Parameters During Awake and Sleep in Refractory and Controlled Epileptic Patients.

Int J Gen Med 2022 8;15:3865-3877. Epub 2022 Apr 8.

Department of Internal Medicine, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

Background: Alterations of heart rate variability (HRV) in epileptic patients were the field of interest of several studies for many reasons, particularly the contribution toward sudden unexpected death in epilepsy (SUDEP).

Aim: We aimed at evaluation of autonomic dysfunction in epileptic patients during awake and sleep in addition to studying the association between SUDEP risk with different Holter parameters.

Patients And Methods: The study included eighty epileptic patients (40 controlled epileptic patients and 40 refractory epileptic patients) compared to 30 volunteers as control group. Read More

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Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study.

Front Neurosci 2022 16;16:736437. Epub 2022 Mar 16.

Department of Psychology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.

Working memory functions are known to be altered after total sleep deprivation (TSD). However, few studies have explored the deficits of working memory updating (WMU) after TSD, or the underlying electrophysiological mechanisms of these alterations. In the current exploratory study, we enrolled 14 young male volunteers who performed two kinds of WMU tasks-spatial and object two-back tasks-with simultaneous electroencephalography recordings under two sleep conditions: a normal sleep baseline condition and after 36 h of TSD. Read More

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Efficiency moderates the relationship between sleep-onset insomnia and resting-state electroencephalogram microstate.

J Integr Neurosci 2022 Mar;21(2):52

College of Health Solutions, Arizona State University, Tempe, AZ 85281, USA.

Background: Overactivation of the salience network (SN) causes hyperarousal in insomnia patients and is associated with sleep-onset insomnia (SOI). Resting-state microstate 3 (RS-MS3) duration is closely related to SN overactivation. However, whether RS-MS3 duration is a biomarker for SOI has not yet been reported in the literature. Read More

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Bottom-Up and Top-Down Attention Impairment Induced by Long-Term Exposure to Noise in the Absence of Threshold Shifts.

Front Neurol 2022 1;13:836683. Epub 2022 Mar 1.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Objective: We aimed to assess the effect of noise exposure on bottom-up and top-down attention functions in industrial workers based on behavioral and brain responses recorded by the multichannel electroencephalogram (EEG).

Method: In this cross-sectional study, 563 shipyard noise-exposed workers with clinical normal hearing were recruited for cognitive testing. Personal cumulative noise exposure (CNE) was calculated with the long-term equivalent noise level and employment duration. Read More

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Local slow-wave activity over the right prefrontal cortex reveals individual risk preferences.

Neuroimage 2022 06 10;253:119086. Epub 2022 Mar 10.

Department of Social Neuroscience and Social Psychology, Institute of Psychology, University of Bern, Fabrikstrasse 8, Bern 3012, Switzerland. Electronic address:

In everyday life, we have to make decisions under varying degrees of risk. Even though previous research has shown that the manipulation of sleep affects risky decision-making, it remains unknown whether individual, temporally stable neural sleep characteristics relate to individual differences in risk preferences. Here, we collected sleep data under normal conditions in fifty-four healthy adults using a portable high-density EEG at participants' home. Read More

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Outcome following surgery for insulo-opercular epilepsies.

J Neurosurg 2022 Mar 11:1-11. Epub 2022 Mar 11.

1Department of Neurosurgery and.

Objective: The purpose of this study was to evaluate the clinical outcome in patients with medically refractory epilepsy who had undergone resective or ablative surgery for suspected insulo-opercular epileptogenic foci.

Methods: The prospectively maintained database of patients undergoing epilepsy surgery was reviewed, and all patients who underwent insulo-opercular surgery for medically refractory epilepsy with a minimum of 12 months of postoperative follow-up were identified, excluding those who had insulo-opercular resection in combination with temporal lobectomy. The presurgical electroclinicoradiological data, stereo-EEG (SEEG) findings, resection/ablation patterns, surgical pathology, postoperative seizure outcome, and neurological complications were analyzed. Read More

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A practical approach toward interpretation of amplitude integrated electroencephalography in preterm infants.

Eur J Pediatr 2022 Jun 8;181(6):2187-2200. Epub 2022 Mar 8.

Hospital for Sick Children, Toronto, Canada.

The developing preterm brain is vulnerable to injury, especially during periods of clinical instability; therefore, monitoring the brain may provide important information on brain health. Over the last 2 decades, a growing body of literature has been reported on preterm amplitude integrated electroencephalography (aEEG) with regards to normative data and associations with adverse outcomes. Despite this, the use of aEEG for preterm infants remains mostly a research tool with limited clinical applicability. Read More

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Longitudinal Analysis of Sleep-Wake States in Neonatal Rats Subjected to Hypoxia-Ischemia.

Nat Sci Sleep 2022 1;14:335-346. Epub 2022 Mar 1.

Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

Objective: Sleep is necessary for brain maturation in infants. Perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of chronic neurological disease in infants. Although the developmental changes of electroencephalogram (EEG) in human newborns have been described, little is known about the EEG normal maturation characteristics in rodents and the changes in sleep-awake states caused by hypoxia-ischemia (HI). Read More

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Conditional Knockout of in Corticotropin-Releasing Factor Neurons Does Not Alter Sleep-Wake Rhythm in Mice.

Front Neurosci 2021 18;15:808754. Epub 2022 Feb 18.

Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.

Sleep and wakefulness are regulated by both the homeostatic mechanism and circadian clock. In mammals, the central circadian clock, the suprachiasmatic nucleus, in the hypothalamus plays a crucial role in the timing of physiology and behavior. Recently, we found that the circadian regulation of wakefulness was transmitted corticotropin-releasing factor (CRF) neurons in the paraventricular nucleus of the hypothalamus to orexin neurons in the lateral hypothalamus. Read More

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February 2022

Rhythmicity in heart rate and its surges usher a special period of sleep, a likely home for PGO waves.

Curr Res Physiol 2022 15;5:118-141. Epub 2022 Feb 15.

Lab. for Human Brain Dynamics, AAI Scientific Cultural Services Ltd., Nicosia, 1065, Cyprus.

High amplitude electroencephalogram (EEG) events, like unitary K-complex (KC), are used to partition sleep into stages and hence define the hypnogram, a key instrument of sleep medicine. Throughout sleep the heart rate (HR) changes, often as a steady HR increase leading to a peak, what is known as a heart rate surge (HRS). The hypnogram is often unavailable when most needed, when sleep is disturbed and the graphoelements lose their identity. Read More

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February 2022

Deep Learning Application to Clinical Decision Support System in Sleep Stage Classification.

J Pers Med 2022 Jan 20;12(2). Epub 2022 Jan 20.

Institute of New Frontier Research, Division of Big Data and Artificial Intelligence, Chuncheon Sacred Heart Hospital, Chuncheon 24252, Korea.

Recently, deep learning for automated sleep stage classification has been introduced with promising results. However, as many challenges impede their routine application, automatic sleep scoring algorithms are not widely used. Typically, polysomnography (PSG) uses multiple channels for higher accuracy; however, the disadvantages include a requirement for a patient to stay one or more nights in the lab wearing uncomfortable sensors and wires. Read More

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January 2022

Lucid dreaming occurs in activated rapid eye movement sleep, not a mixture of sleep and wakefulness.

Sleep 2022 04;45(4)

Stanford University.

Study Objectives: (1) To critically test whether a previously reported increase in frontolateral 40 Hz power in lucid REM sleep, used to justify the claim that lucid dreaming is a "hybrid state" mixing sleep and wakefulness, is attributable to the saccadic spike potential (SP) artifact as a corollary of heightened REM density. (2) To replicate the finding that lucid dreams are associated with physiological activation, including heightened eye movement density, during REM sleep. (3) To conduct an exploratory analysis of changes in EEG features during lucid REM sleep. Read More

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SQNN: a spike-wave index quantification neural network with a pre-labeling algorithm for epileptiform activity identification and quantification in children.

J Neural Eng 2022 02 28;19(1). Epub 2022 Feb 28.

Department of Neurology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Electrical status epilepticus during slow sleep (ESES) is a phenomenon identified by strong activation of epileptiform activity in the electroencephalogram (EEG) during sleep. For children disturbed by ESES, spike-wave index (SWI) is defined to quantify the epileptiform activity in the EEG during sleep. Accurate SWI quantification is important for clinical diagnosis and prognosis. Read More

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February 2022

SQNN: A Spike-wave index Quantification Neural Network with a pre-labeling algorithm for epileptiform activity identification and quantification in children.

J Neural Eng 2022 Feb 9. Epub 2022 Feb 9.

Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, No.1678 Dongfang Road, Pudong New District, Shanghai, 200127, CHINA.

Objective: Electrical status epilepticus during slow sleep (ESES) is a phenomenon identified by strong activation of epileptiform activity in the electroencephalogram (EEG) during sleep. For children disturbed by ESES, spike-wave index (SWI) is defined to quantify the epileptiform activity in the EEG during sleep. Accurate SWI quantification is important for clinical diagnosis and prognosis. Read More

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February 2022

The NMT Scalp EEG Dataset: An Open-Source Annotated Dataset of Healthy and Pathological EEG Recordings for Predictive Modeling.

Front Neurosci 2021 5;15:755817. Epub 2022 Jan 5.

School of Electrical Engineering and Computer Science, National University of Sciences and Technology (NUST), Islamabad, Pakistan.

Electroencephalogram (EEG) is widely used for the diagnosis of neurological conditions like epilepsy, neurodegenerative illnesses and sleep related disorders. Proper interpretation of EEG recordings requires the expertise of trained neurologists, a resource which is scarce in the developing world. Neurologists spend a significant portion of their time sifting through EEG recordings looking for abnormalities. Read More

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January 2022

Sleep-Dependent Anomalous Cortical Information Interaction in Patients With Depression.

Front Neurosci 2021 6;15:736426. Epub 2022 Jan 6.

Department of Psychology, Guangdong 999 Brain Hospital, Guangzhou, China.

Depression is a prevalent mental illness with high morbidity and is considered the main cause of disability worldwide. Brain activity while sleeping is reported to be affected by such mental illness. To explore the change of cortical information flow during sleep in depressed patients, a delay symbolic phase transfer entropy of scalp electroencephalography signals was used to measure effective connectivity between cortical regions in various frequency bands and sleep stages. Read More

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January 2022

Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy.

Brain Sci 2021 Dec 27;12(1). Epub 2021 Dec 27.

Diagnóstico, Tratamiento e Investigación Neurológica, S. C. Querétaro, Santiago de Queretaro 76177, Mexico.

Juvenile myoclonic epilepsy (JME) appears in adolescence with myoclonic, absence, and generalized tonic clonic (GTC) seizures with paroxysmal activity of polyspike and slow wave (PSW), or spike and wave (SW) complexes in EEG. Our aim was to analyze the clinical characteristics, background EEG activity, and paroxysmal events in 41 patients with JME. Background EEG activity was analyzed with visual, quantitative (QEEG), and neurometric parameters. Read More

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December 2021