3,598 results match your criteria Normal Pressure Hydrocephalus


Natural history of ventriculomegaly in adults: a cluster analysis.

J Neurosurg 2019 Feb 8:1-8. Epub 2019 Feb 8.

OBJECTIVEChronic ventriculomegaly in the absence of raised intracranial pressure (ICP) is a known entity in adult hydrocephalus practice. The natural history and indication for treatment is, however, poorly defined. A highly heterogeneous group, some adults with ventriculomegaly are asymptomatic, while others have life-threatening deteriorations. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18119DOI Listing
February 2019
1 Read

Long-Term Effect of Decompressive Craniectomy on Intracranial Pressure and Possible Implications for Intracranial Fluid Movements.

Neurosurgery 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.

Background: Decompressive craniectomy (DC) is used in cases of severe intracranial hypertension or impending intracranial herniation. DC effectively lowers intracranial pressure (ICP) but carries a risk of severe complications related to abnormal ICP and/or cerebrospinal fluid (CSF) circulation, eg, hygroma formation, hydrocephalus, and "syndrome of the trephined."

Objective: To study the long-term effect of DC on ICP, postural ICP regulation, and intracranial pulse wave amplitude (PWA). Read More

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http://dx.doi.org/10.1093/neuros/nyz049DOI Listing
February 2019

Structure and function of proprotein convertase subtilisin/kexin type 9 (PCSK9) in atherosclerosis.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214141626DOI Listing
February 2019
3.021 Impact Factor

Recent advances in rational diagnosis and treatment of normal pressure hydrocephalus: A critical appraisal on novel diagnostic, therapy monitoring and treatment modalities.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214121342DOI Listing
February 2019
3.021 Impact Factor

Hemodynamically self-corrected δadc analysis in idiopathic normal pressure hydrocephalus.

Br J Radiol 2019 Feb 13:20180553. Epub 2019 Feb 13.

1 Department of Radiology, Kouseiren Takaoka Hospital , Takaoka, Toyama , Japan.

Objective:: To clarify the cause of higher water fluctuation of the brain in idiopathic normal pressure hydrocephalus (iNPH), we assessed change in hemodynamic-independent apparent diffusion coefficient during the cardiac cycle (ΔADC) in iNPH.

Methods:: Electrocardiographically synchronized single-shot diffusion echo-planer (b = 0, 500, and 1000  s/mm ) was performed in healthy volunteers, atrophic ventricular dilation group, and iNPH group, respectively. The ΔADC (b = 0  and 1000  s/mm ) and maximum ADC (b = 0  and 500  s/mm ) in the cardiac cycles were measured at the frontal white matter in the brain. Read More

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http://dx.doi.org/10.1259/bjr.20180553DOI Listing
February 2019

Comorbidity of diabetes mellitus in idiopathic normal pressure hydrocephalus: a systematic literature review.

Fluids Barriers CNS 2019 Feb 12;16(1). Epub 2019 Feb 12.

Department of Neurosurgery, Wayne State University, 51 W Palmer ave, Detroit, MI, 48202, USA.

Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of hydrocephalus that occurs more often in the elderly population. It is usually characterized by gait disturbance, dementia and urinary incontinence. Epidemiological studies indicate that 15. Read More

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http://dx.doi.org/10.1186/s12987-019-0125-xDOI Listing
February 2019

Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus versus Alzheimer's Disease and Subcortical Ischemic Vascular Disease: A Systematic Review.

J Alzheimers Dis 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurology, Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen OE, Denmark.

Background: The diagnostic workup of idiopathic normal pressure hydrocephalus (iNPH) can be challenging due to an overlap in symptoms and neuroimaging features with other disorders. Despite a growing interest, a cerebrospinal fluid (CSF) biomarker profile in iNPH has not yet been identified.

Objective: To determine the CSF biomarkers with the greatest evidence for differentiating iNPH from the most common differential diagnoses, Alzheimer's disease (AD) and subcortical ischemic vascular disease (SIVD). Read More

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http://dx.doi.org/10.3233/JAD-180816DOI Listing
February 2019
1 Read

The Computerized General Neuropsychological INPH Test revealed improvement in idiopathic normal pressure hydrocephalus after shunt surgery.

J Neurosurg 2019 Feb 8:1-8. Epub 2019 Feb 8.

2Department of Pharmacology and Clinical Neuroscience.

OBJECTIVEThe Computerized General Neuropsychological INPH Test (CoGNIT) provides the clinician and the researcher with standardized and accessible cognitive assessments in patients with idiopathic normal pressure hydrocephalus (INPH). CoGNIT includes tests of memory, executive functions, attention, manual dexterity, and psychomotor speed. Investigations of the validity and reliability of CoGNIT have been published previously. Read More

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http://dx.doi.org/10.3171/2018.10.JNS18701DOI Listing
February 2019

Dynamic balance measurements can differentiate fallers from non-fallers in patients with idiopathic normal pressure hydrocephalus.

Arch Phys Med Rehabil 2019 Feb 4. Epub 2019 Feb 4.

Department of Physical and Rehabilitation Medicine, Division of Comprehensive Medicine, Osaka Medical College, Osaka, Japan.

Objectives: To investigate which clinical assessments are suitable for differentiating fallers from non-fallers in patients with idiopathic normal pressure hydrocephalus (iNPH).

Design: Prospective observational study.

Setting: Medical College Hospital. Read More

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http://dx.doi.org/10.1016/j.apmr.2019.01.008DOI Listing
February 2019
1 Read

Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections.

J Infect Dis 2019 Feb 5. Epub 2019 Feb 5.

Centre for Individualized Infection Medicine, Hannover, Germany.

Background: The tryptophan-kynurenine-NAD+ pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in CNS infections would improve our understanding of pathophysiology and end-organ damage, and, furthermore, open doors to its evaluation as a source of diagnostic and/or prognostic biomarkers.

Methods: We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 220 cerebrospinal fluid samples from patients with bacterial and viral (herpes simplex, varicella zoster, enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (anti-NMDA-R encephalitis, multiple sclerosis), and noninflamed controls (Bell's palsy, normal pressure hydrocephalus, Tourette syndrome). Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz048DOI Listing
February 2019
7 Reads

Normal Pressure Hydrocephalus.

Continuum (Minneap Minn) 2019 Feb;25(1):165-186

Purpose Of Review: Since it was first described in 1965, normal pressure hydrocephalus (NPH) has been a controversial subject. New studies have shed light on its epidemiology and pathogenesis and provided objective ways to measure outcome in patients with NPH. Neuroimaging has improved and allows better recognition of both NPH and the presence of overlapping diseases RECENT FINDINGS: Several recent epidemiologic studies confirm that NPH is a rare disease, but the presence of large ventricles is a common finding with aging. Read More

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http://dx.doi.org/10.1212/CON.0000000000000689DOI Listing
February 2019
7 Reads

Quantitative Evaluation of Gait Disturbance on an Instrumented Timed Up-and-go Test.

Aging Dis 2019 Feb 1;10(1):23-36. Epub 2019 Feb 1.

1Normal Pressure Hydrocephalus Center, Rakuwakai Otowa Hospital, Rakuwakai Healthcare System, Kyoto, Japan.

Although the 3-m timed up-and-go test (TUG) is reliable for evaluating mobility, TUG time is insufficient to evaluate mild gait disturbance; we, therefore aimed to investigate other measurements with instrumented TUG (iTUG) using a free smartphone application. Our inclusion criterion in this study is only that participants can walk without any assistance. This study included three heterogeneous groups; patients who underwent a tap test or shunt surgery, 29 inpatients hospitalized for other reasons, and 87 day-care users. Read More

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http://dx.doi.org/10.14336/AD.2018.0426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345343PMC
February 2019

Considerations for Patients With Idiopathic Normal Pressure Hydrocephalus Undergoing Cardiac Surgery.

J Cardiothorac Vasc Anesth 2018 Nov 14. Epub 2018 Nov 14.

Department of Cardiac Surgery, Athens Medical Center, Athens, Greece.

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http://dx.doi.org/10.1053/j.jvca.2018.11.008DOI Listing
November 2018

[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-β Load in Subjects Examined for Normal Pressure Hydrocephalus.

J Alzheimers Dis 2019 Jan 21. Epub 2019 Jan 21.

Institute of Clinical Medicine, Neurosurgery, University of Eastern Finland, Kuopio, Finland.

Background: Idiopathic normal pressure hydrocephalus (iNPH) is frequently associated with concomitant amyloid-β (Aβ) pathology.

Objective: To compare the [11C]PIB PET uptake in the patients with suspected iNPH to Aβ and hyperphosphorylated-tau (HPτ) in the right frontal cortical biopsy, the cerebrospinal fluid (CSF) Aβ, the response to a CSF shunt, and the final clinical diagnosis of Alzheimer's disease (AD).

Methods: Patients (n = 21) from Kuopio NPH Registry (http://www. Read More

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http://dx.doi.org/10.3233/JAD-180645DOI Listing
January 2019

DTI Profiles for Rapid Description of Cohorts at the Clinical-Research Interface.

Front Med (Lausanne) 2018 10;5:357. Epub 2019 Jan 10.

Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.

Normal pressure hydrocephalus (NPH) is a syndrome comprising gait disturbance, cognitive decline and urinary incontinence that is an unique model of reversible brain injury, but it presents as a challenging spectrum of disease cohorts. Diffusion Tensor Imaging (DTI), with its ability to interrogate structural white matter patterns at a microarchitectural level, is a potentially useful tool for the confirmation and characterization of disease cohorts at the clinical-research interface. However, obstacles to its widespread use involve the need for consistent DTI analysis and interpretation tools across collaborator sites. Read More

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http://dx.doi.org/10.3389/fmed.2018.00357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335243PMC
January 2019

Gait analysis in a component timed-up-and-go test using a smartphone application.

J Neurol Sci 2019 Jan 16;398:45-49. Epub 2019 Jan 16.

Digital Standard Co., Ltd., 2-6-24 Sonezakishinchi, Kita-ku, Osaka, Japan. Electronic address:

Background: The timed-up-and-go test (TUG) is a popular test for mobility, but it only measures the total time to complete tasks. Recent advances in smartphone technology enables measuring respective times of 6 components in the test (Stand, Go, Turn1, Come, Turns and Sit). We examined availability of these data for assessing different gait patterns. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.023DOI Listing
January 2019

A prospective study on gait dominant normal pressure hydrocephalus.

Acta Neurol Scand 2019 Jan 24. Epub 2019 Jan 24.

Barrow Neurological Institute, Dignity Health Organization, St. Joseph Hospital and Medical Center, Phoenix, Arizona.

Object: We characterize idiopathic normal pressure hydrocephalus (NPH) following treatment with lumbar puncture (LP) and shunt placement through clinical evaluation and quantitative ProtoKinetics Zeno walkway assessments. We evaluate the symptomology by determining gait characteristics altered by treatment.

Methods: Patients at Barrow Neurological Institute (BNI) who underwent a LP, removing 30-32 mL cerebrospinal fluid) followed by ventriculoperitoneal shunt placement in February 2015 to February 2017 were analyzed for gait impairments. Read More

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http://dx.doi.org/10.1111/ane.13064DOI Listing
January 2019
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Opposing CSF hydrodynamic trends found in the cerebral aqueduct and prepontine cistern following shunt treatment in patients with normal pressure hydrocephalus.

Fluids Barriers CNS 2019 Jan 22;16(1). Epub 2019 Jan 22.

Neural Systems and Dynamics Laboratory, Department of Neurosurgery, The David Geffen School of Medicine, University of California-Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.

Background: This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the prepontine cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Read More

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http://dx.doi.org/10.1186/s12987-019-0122-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341759PMC
January 2019

Location-specific characteristics of perivascular spaces as the brain's interstitial fluid drainage system.

J Neurol Sci 2019 Jan 16;398:9-15. Epub 2019 Jan 16.

Interfaculty Initiative in Information Studies / Institute of Industrial Science, The University of Tokyo, Tokyo, Japan. Electronic address:

Purpose: Brain interstitial fluid plays an important role in the excretion of metabolic waste products into the cerebrospinal fluid through perivascular spaces (PVS). To investigate the normal function of PVS in healthy elderly individuals, we assessed the relationship between PVS and white matter hyperintensity (WMH) on MRI in two locations.

Methods: This study included 296 healthy individuals aged ≥60 years without a history of brain disease who underwent brain MRI. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.022DOI Listing
January 2019
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Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis.

Int J Mol Sci 2019 Jan 15;20(2). Epub 2019 Jan 15.

Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Enteroviruses are among the most common causes of viral meningitis. Enteroviral meningitis continues to represent diagnostic challenges, as cerebrospinal fluid (CSF) cell numbers (a well validated diagnostic screening tool) may be normal in up to 15% of patients. We aimed to identify potential CSF biomarkers for enteroviral meningitis, particularly for cases with normal CSF cell count. Read More

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http://dx.doi.org/10.3390/ijms20020337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359617PMC
January 2019
2 Reads

Obstructive sleep apnea in patients with idiopathic normal-pressure hydrocephalus.

Authors:
Tomoyuki Kawada

J Neurol Sci 2019 Feb 10;397:155. Epub 2019 Jan 10.

Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo 113-8602, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193000
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http://dx.doi.org/10.1016/j.jns.2019.01.006DOI Listing
February 2019
4 Reads

Repeated Cerebrospinal Fluid Removal Procedure in Older Patients With Idiopathic Normal Pressure Hydrocephalus Ineligible for Surgical Treatment.

J Am Med Dir Assoc 2019 Jan 9. Epub 2019 Jan 9.

Department of Neurosurgery, Moriggia-Pelascini Hospital, Gravedona, Como, Italy.

Objectives: To evaluate the effects of repeated cerebrospinal fluid (CSF) tap procedures in idiopathic normal pressure hydrocephalus (iNPH) patients ineligible for surgical treatment.

Design: Prospective, monocentric, pilot study.

Setting: University hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15258610183066
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http://dx.doi.org/10.1016/j.jamda.2018.11.014DOI Listing
January 2019
4 Reads

Neuropsychiatric Manifestations of Cognitively Advanced Idiopathic Normal Pressure Hydrocephalus.

Dement Geriatr Cogn Dis Extra 2018 Sep-Dec;8(3):467-475. Epub 2018 Dec 6.

Department of Neurology, Pushpagiri Institute for Medical Sciences, Thiruvalla, India.

Background: Neuropsychiatric manifestations of patients with idiopathic normal pressure hydrocephalus (iNPH) have not been studied in a systematic way.

Aim: To study the spectrum of neuropsychiatric abnormalities in patients with iNPH.

Patient Selection And Evaluation: Patients attending 3 different tertiary care centers during three consecutive time periods spanning from 2010 to 2015 were analyzed for neuropsychiatric manifestations. Read More

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https://www.karger.com/Article/FullText/493914
Publisher Site
http://dx.doi.org/10.1159/000493914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323371PMC
December 2018
8 Reads

Exclusive use of fixed pressure valves for cerebrospinal fluid diversion in a modern adult cohort.

Heliyon 2018 Dec 29;4(12):e01099. Epub 2018 Dec 29.

Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Background: There is extensive debate on the role of fixed pressure shunts in the adult population. Most studies assessing fixed pressure valves do not consider the potential for changes in technique and management of shunts. We sought to examine the natural history of fixed pressure. Read More

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http://dx.doi.org/10.1016/j.heliyon.2018.e01099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312827PMC
December 2018

Idiopathic normal-pressure hydrocephalus.

Authors:
Tina Hu Yuna Lee

CMAJ 2019 Jan;191(1):E15

Department of Family and Community Medicine (Hu) and Division of General Internal Medicine (Lee), St. Michael's Hospital, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.180877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312516PMC
January 2019
1 Read

Reversible intracranial hypertension following treatment of an extracranial vascular malformation: case report.

J Neurosurg Pediatr 2019 Jan 4:1-5. Epub 2019 Jan 4.

3Neurointerventional Radiology, Boston Children's Hospital, Boston, Massachusetts.

Pediatric hydrocephalus is a well-studied and still incompletely understood entity. One of the physiological means by which hydrocephalus and intracranial hypertension evolve is through perturbations to normal vascular dynamics. Here the authors report a unique case of an extracranial vascular anomaly resulting in persistently elevated intracranial pressures (ICPs) independent of CSF diversion in a patient with a Joubert syndrome-related disorder. Read More

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http://dx.doi.org/10.3171/2018.10.PEDS18235DOI Listing
January 2019
2 Reads

Lumbar drain trial outcomes of normal pressure hydrocephalus: a single-center experience of 254 patients.

J Neurosurg 2019 Jan 4:1-7. Epub 2019 Jan 4.

1Department of Neurological Surgery.

OBJECTIVEA short-term lumbar drain (LD) trial is commonly used to assess the response of normal pressure hydrocephalus (NPH) patients to CSF diversion. However, it remains unknown whether the predictors of passing an LD trial match the predictors of improvement after ventriculoperitoneal shunting. The aim of this study was to examine outcomes, complication rates, and associations between predictors and outcomes after an LD trial in patients with NPH. Read More

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http://dx.doi.org/10.3171/2018.8.JNS181059DOI Listing
January 2019
2 Reads

Unusual case of idiopathic normal pressure hydrocephalus initially presenting as Parinaud's syndrome?

Authors:
Halil Onder

Geriatr Gerontol Int 2019 Jan;19(1):83

Neurology Clinic, Yozgat City Hospital, Yozgat, Turkey.

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http://dx.doi.org/10.1111/ggi.13584DOI Listing
January 2019
6 Reads

Reply to the comments on "Unusual case of idiopathic normal pressure hydrocephalus initially presenting as Parinaud's syndrome?"

Geriatr Gerontol Int 2019 Jan;19(1):84-85

Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/ggi.13582DOI Listing
January 2019

Acute subdural hematomas in shunted normal-pressure hydrocephalus patients - Management options and literature review: A case-based series.

Surg Neurol Int 2018 28;9:238. Epub 2018 Nov 28.

Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv Medical Center, Tel-Aviv, Israel.

Background: Ventriculoperitoneal shunting (VPS) is considered a risk factor for developing subdural hematomas (SDH). Treating cases of acute SDH (aSDH) in shunted normal-pressure hydrocephalus (NPH) patients can be challenging, and data in this field are scarce. We report our experience treating shunted NPH patients presenting with aSDH. Read More

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http://dx.doi.org/10.4103/sni.sni_338_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287333PMC
November 2018
1 Read

Copy number loss in is common among Finnish and Norwegian patients with iNPH.

Neurol Genet 2018 Dec 3;4(6):e291. Epub 2018 Dec 3.

Department of Neurosurgery (V.E.K., A. Jokinen, I.J., J.-M.L., A. Junkkari, J.E.J., V.L.), Kuopio University Hospital and University of Eastern Finland; Institute of Clinical Medicine-Neurology (S.H., M.H., H. Soininen, A.M.K.), University of Eastern Finland, Kuopio; Department of Neurosurgery (M.O., K.L.), University of Helsinki and Helsinki University Hospital; Clinical Neurosciences (C.A., A.K., J.F., J.R.), Department of Neurosurgery, University of Turku and Turku University Hospital; Department of Neurosurgery (A.R.), Tampere University Hospital; Unit of Clinical Neuroscience (M. Kauppinen, V.L.), Neurosurgery, University of Oulu and Medical Research Center, Oulu University Hospital; Institute of Biomedicine (M.H.), University of Eastern Finland, Kuopio; Analytical and Translational Genetics Unit (M. Kurki), Department of Medicine, Massachusetts General Hospital; Program in Medical and Population Genetics (M. Kurki), Broad Institute of MIT and Harvard; Stanley Center for Psychiatric Research (M. Kurki), Broad Institute for Harvard and MIT; Department of Neurology (H. Sato, T.K.), Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan; Medical Research Center (A.M.R.), Oulu University Hospital, Finland; Unit of Clinical Neuroscience (A.M.R.), Neurology, University of Oulu, Finland; Department of Neurosurgery (P.K.E.), Oslo University Hospital-Rikshospitalet; and Institute of Clinical Medicine (P.K.E.), Faculty of Medicine, University of Oslo, Norway.

Objective: To evaluate the role of the copy number loss in in a Caucasian population.

Methods: Five hundred sixty-seven Finnish and 377 Norwegian patients with idiopathic normal pressure hydrocephalus (iNPH) were genotyped and compared with 508 Finnish elderly, neurologically healthy controls. The copy number loss in intron 2 of was determined using quantitative PCR. Read More

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http://dx.doi.org/10.1212/NXG.0000000000000291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283454PMC
December 2018
1 Read

Stent-assisted Coil Embolization for a Ruptured Posterior Communicating Artery Pseudoaneurysm after Endoscopic Trans-sphenoidal Surgery for Pituitary Adenoma.

World Neurosurg 2018 Dec 21. Epub 2018 Dec 21.

Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino-city, Japan.

Background: Intracranial pseudoaneurysm is a rare complication of endoscopic endonasal surgery. Herein, we describe two-staged stent-assisted coil embolization for posterior communicating artery pseudoaneurysm after endoscopic endonasal surgery for pituitary adenoma.

Case Description: A 68-year-old man had a history of severe adult growth hormone secretion deficiency, requiring growth hormone replacement therapy; secondary adrenocortical hypofunction; hyperthyroidism; hypertension; constipation; glaucoma; and hyperuricemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183287
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http://dx.doi.org/10.1016/j.wneu.2018.12.047DOI Listing
December 2018
6 Reads

Surgical treatment of post-inflammatory hydrocephalus. Analysis of 101 cases.

Childs Nerv Syst 2019 Feb 18;35(2):237-243. Epub 2018 Dec 18.

Department of Neurosurgery and Neurotraumatology, Polish Mothers Memorial Hospital Research Institute, 281/289 Rzgowska street, 93-338, Lodz, Poland.

Objective: The aim of this paper was to evaluate the outcomes of surgical treatment for post-inflammatory hydrocephalus in pediatric patients. The patient's age, surgical technique and type of implants, revision rate (depending on the cause for revision and shunt type), and final outcome measured with Neurologic Outcome Scale for Infants and Children (NOSIC) scale were evaluated.

Methods: We performed a retrospective analysis of 101 patients with post-inflammatory hydrocephalus, treated in Polish Mother's Memorial Hospital Research Institute since 2005. Read More

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http://dx.doi.org/10.1007/s00381-018-4022-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351511PMC
February 2019
8 Reads

Changes in Cognitive Function Scores After Cerebrospinal Fluid Tap Testing in Patients with Suspected Idiopathic Normal-Pressure Hydrocephalus.

Cogn Behav Neurol 2018 Dec;31(4):201-206

Neurosurgery.

Background: In patients suspected of having idiopathic normal-pressure hydrocephalus (iNPH), improvement in impaired cognition is common after a diagnostic cerebrospinal fluid tap test (CSFTT). Measures used to evaluate cognitive function before and after a CSFTT include the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Trail Making Test (TMT). However, the time point at which cognitive function should be reevaluated after a CSFTT remains controversial. Read More

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http://dx.doi.org/10.1097/WNN.0000000000000176DOI Listing
December 2018

Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension.

Radiol Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, BezmialemVakif University, Istanbul, Turkey.

Purpose: To search for CSF dynamics of idiopathic intracranial hypertension (IIH) and communicating hydrocephalus and any correlation between MRI findings, CSF metrics and CSF opening pressure in IIH.

Materials And Methods: Healthy subjects (30) and subjects with IIH (29) and high-pressure communicating hydrocephalus (43) were enrolled. Nonparametric Kruskal-Wallis test (p = 0. Read More

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http://link.springer.com/10.1007/s11547-018-0979-z
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http://dx.doi.org/10.1007/s11547-018-0979-zDOI Listing
December 2018
5 Reads
1.368 Impact Factor

Meningeal carcinomatosis presenting with leukoencephalopathy-like imaging findings.

eNeurologicalSci 2019 Mar 19;14:21-23. Epub 2018 Nov 19.

Department of Neurology, University of Tsukuba, 1-1-1 Tenodai, Tsukuba-city, Japan.

Meningeal carcinomatosis is a unique and rare form of metastasis observed in patients with malignant tumours. Diagnosis is simple when the primary lesion of the malignant tumour is clear, and when multiple miliary lesions are confirmed via cranial contrast MRI; however, many patients exhibit atypical imaging findings. In the present report, we discuss the case of a 72-year-old man who presented with subacute consciousness impairment and MRI findings suggestive of progressive, bilateral leukoencephalopathy-like lesions around the ventricles. Read More

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http://dx.doi.org/10.1016/j.ensci.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275227PMC
March 2019
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Absence of Disproportionately Enlarged Subarachnoid Space Hydrocephalus, a Sharp Callosal Angle, or Other Morphologic MRI Markers Should Not Be Used to Exclude Patients with Idiopathic Normal Pressure Hydrocephalus from Shunt Surgery.

AJNR Am J Neuroradiol 2019 Jan 6;40(1):74-79. Epub 2018 Dec 6.

From the Hydrocephalus Research Unit (S.A., M.W., P.H., C.W., M.T.), Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology.

Background And Purpose: Several studies have evaluated the use of MR imaging markers for the prediction of outcome after shunt surgery in idiopathic normal pressure hydrocephalus with conflicting results. Our aim was to investigate the predictive value of a number of earlier proposed morphologic MR imaging markers in a large group of patients with idiopathic normal pressure hydrocephalus.

Materials And Methods: One hundred sixty-eight patients (mean age, 70 ± 9. Read More

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http://dx.doi.org/10.3174/ajnr.A5910DOI Listing
January 2019
2 Reads

Deep Brain Stimulation Surgery for Parkinson Disease Coexisting With Communicating Hydrocephalus: A Case Report.

Front Neurol 2018 23;9:1011. Epub 2018 Nov 23.

Hospital Clínico, Universidad de Chile, Santiago, Chile.

We report a successful bilateral globus pallidus internus-deep brain stimulation (GPi-DBS) for a Parkinson disease (PD) patient with idiopathic normal pressure hydrocephalus (INPH) and an unusually long anterior commissure-posterior commissure (AC-PC) line. A 54-year-old man presented with a history of 3 months of severe shuffling gait, rigidity, slow movements of the left side limbs, and difficulty managing finances. A brain MRI revealed marked ventriculomegaly (Evans index = 0. Read More

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http://dx.doi.org/10.3389/fneur.2018.01011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265407PMC
November 2018
3 Reads

Cord Compression Caused by a Tangled and Warped Lumbar Catheter After Lumboperitoneal Shunt Placement.

Neurospine 2018 Oct 2. Epub 2018 Oct 2.

Department of Neurosurgery, Tohoku University, Graduate School of Medicine, Sendai, Japan.

The present study reports the case of an 81-year-old woman who underwent lumboperitoneal shunt (LPS) placement for idiopathic normal-pressure hydrocephalus. After LPS placement, the patient presented with radicular pain. A computed tomography scan revealed that the intradural lumbar catheter was tangled at the T11 vertebra; therefore, we decided to remove the catheter under local anesthesia. Read More

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http://e-neurospine.org/journal/view.php?doi=10.14245/ns.183
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http://dx.doi.org/10.14245/ns.1836114.057DOI Listing
October 2018
6 Reads

Abnormal Gray Matter Structural Networks in Idiopathic Normal Pressure Hydrocephalus.

Front Aging Neurosci 2018 15;10:356. Epub 2018 Nov 15.

Department of Radiology, Huashan Hospital of Fudan University, Shanghai, China.

: Idiopathic normal pressure hydrocephalus (iNPH) is known as a treatable form of dementia. Network analysis is emerging as a useful method to study neurological disorder diseases. No study has examined changes of structural brain networks of iNPH patients. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249342PMC
November 2018
2 Reads

Automated detection of imaging features of disproportionately enlarged subarachnoid space hydrocephalus using machine learning methods.

Neuroimage Clin 2018 Nov 19. Epub 2018 Nov 19.

Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.

Objective: Create an automated classifier for imaging characteristics of disproportionately enlarged subarachnoid space hydrocephalus (DESH), a neuroimaging phenotype of idiopathic normal pressure hydrocephalus (iNPH).

Methods: 1597 patients from the Mayo Clinic Study of Aging (MCSA) were reviewed for imaging characteristics of DESH. One core feature of DESH, the presence of tightened sulci in the high-convexities (THC), was used as a surrogate for the presence of DESH as the expert clinician-defined criterion on which the classifier was trained. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.11.015DOI Listing
November 2018
2 Reads

Accuracy and safety of 1-day external lumbar drainage of CSF for shunt selection in patients with idiopathic normal pressure hydrocephalus.

J Neurosurg 2018 Nov 1:1-7. Epub 2018 Nov 1.

5Neurosurgery Unit, "Ospedali Riuniti" of Trieste, Cattinara, Italy.

OBJECTIVEThree to five days of external lumbar drainage (ELD) of CSF is a test for ventriculoperitoneal shunt (VPS) selection in idiopathic normal pressure hydrocephalus (iNPH). The accuracy and complication rates of a shorter (1-day) ELD procedure were analyzed.METHODSData of patients with iNPH who underwent 1-day ELD to be selected to undergo VPS placement with a programmable valve in the period from 2005 to 2015 were reviewed. Read More

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http://dx.doi.org/10.3171/2018.6.JNS18400DOI Listing
November 2018
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Outcomes and complications of different surgical treatments for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis.

J Neurosurg 2018 Nov 1:1-13. Epub 2018 Nov 1.

1Department of Neurologic Surgery and.

OBJECTIVEDifferent CSF diversion procedures (ventriculoperitoneal, ventriculoatrial, and lumboperitoneal shunting) have been utilized for the treatment of idiopathic normal pressure hydrocephalus. More recently, endoscopic third ventriculostomy has been suggested as a reasonable alternative in some studies. The purpose of this study was to perform a systematic review and meta-analysis to assess overall rates of favorable outcomes and adverse events for each of these treatments. Read More

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http://dx.doi.org/10.3171/2018.5.JNS1875DOI Listing
November 2018
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Comparison of the CSF dynamics between patients with idiopathic normal pressure hydrocephalus and healthy volunteers.

J Neurosurg 2018 Nov 1:1-6. Epub 2018 Nov 1.

Departments of1Pharmacology and Clinical Neuroscience and.

OBJECTIVEIntracranial pressure (ICP), outflow resistance (Rout), and amplitude of cardiac-related ICP pulsations (AMPs) are established parameters to describe the CSF hydrodynamic system and are assumed, but not confirmed, to be disturbed in idiopathic normal pressure hydrocephalus (INPH). The aim of this study was to compare the CSF hydrodynamic profile between patients with INPH and healthy volunteers.METHODSSixty-two consecutive INPH patients (mean age 74 years) and 40 healthy volunteers (mean age 70 years) were included. Read More

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http://dx.doi.org/10.3171/2018.5.JNS173170DOI Listing
November 2018
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An elderly patient with Alzheimer's Disease, Normal Pressure Hydrocephalus and Traumatic Brain Injury: presented with behavioral symptoms similar to behavioral variant Frontotemporal Dementia.

Int J Neurosci 2018 Nov 26:1-8. Epub 2018 Nov 26.

a Department of Geriatric Medicine , Dokuz Eylul University , Faculty of Medicine , Izmir , Turkey.

Traumatic brain injury (TBI) is nondegenerative insult to brain from external mechanical forces. It may cause cognitive impairment, psychological problems in the long period. Besides traumatic brain injury also induces neuroinflammation and neurodegeneration process, and increases risk of dementia. Read More

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http://dx.doi.org/10.1080/00207454.2018.1552690DOI Listing
November 2018
22 Reads

Apathy and right caudate perfusion in idiopathic normal pressure hydrocephalus: A case-control study.

Int J Geriatr Psychiatry 2019 Mar 21;34(3):453-462. Epub 2018 Dec 21.

Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan.

Objectives: Apathy is prevalent in patients with idiopathic normal pressure hydrocephalus (iNPH), a treatable disorder resulting from ventricular enlargement. We assessed the relationship between apathy and regional cerebral blood flow (rCBF) in patients with iNPH.

Methods: Before lumbo-peritoneal shunt surgery (LPS), 56 iNPH patients were evaluated on apathy and dysphoria subscales of the Neuropsychiatric inventory (NPI), and were divided into two groups according to NPI apathy score: 15 without apathy (iNPH-APA) and 41 with apathy (iNPH+APA). Read More

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http://dx.doi.org/10.1002/gps.5038DOI Listing
March 2019
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Differences in the Calculated Transvenous Pressure Drop between Chronic Hydrocephalus and Idiopathic Intracranial Hypertension.

AJNR Am J Neuroradiol 2019 Jan 22;40(1):68-73. Epub 2018 Nov 22.

Biomedical Engineering (A.R.B.), University of New South Wales, Sydney, New South Wales, Australia.

Background And Purpose: Chronic hydrocephalus is associated with dilated ventricles despite a normal intracranial pressure. In idiopathic intracranial hypertension, the ventricles are normal despite an elevated intracranial pressure. This apparent paradox has largely remained unexplained. Read More

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http://dx.doi.org/10.3174/ajnr.A5883DOI Listing
January 2019

Diffusion Tensor Imaging of the Superior Thalamic Radiation and Cerebrospinal Fluid Distribution in Idiopathic Normal Pressure Hydrocephalus.

J Neuroimaging 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurology, McGovern Medical School, University of Texas Health Science Center (UTHSC), Houston, TX (KY, CEM, ZK, OH, PES).

Background And Purpose: Ventricular enlargement in elderly raises a challenging differential diagnosis to physicians. While Alzheimer's disease is the most common form of dementia, idiopathic normal pressure hydrocephalus (iNPH) constitutes a potentially reversible syndrome. iNPH has a unique pathophysiology pertaining to cerebrospinal fluid (CSF) dynamics and periventricular white matter. Read More

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http://dx.doi.org/10.1111/jon.12581DOI Listing
November 2018
18 Reads