3,631 results match your criteria Normal Pressure Hydrocephalus


Insights into the pathogenesis of normal-pressure hydrocephalus.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Memory and Aging Center, Department of Neurology (S.S.), University of California, San Francisco; School of Medical and Health Sciences (S.M.L.), Edith Cowan University, Australia; and School of Pharmacy and Biomedical Sciences (S.M.L.), Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000007495DOI Listing

Nonsense mutation in causes normal-pressure hydrocephalus with ciliary abnormalities.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Departments of Neuropsychiatry (Y.M., N.Y., H.O.) and Otolaryngology-Head and Neck Surgery (C.S.), Unit of Translation Medicine, and Department of Human Genetics (S.Y., A.K., H.M., K.-i.Y., S.O.), Nagasaki University Graduate School of Biomedical Sciences; Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute (K.M., M.N.), Central Laboratory, Institute of Tropical Medicine (NEKKEN) (M.S.), and Gene Research Center, Center for Frontier Life Sciences (T.K.), Nagasaki University; Department of Infectious Diseases (T.T.) and Child and Adolescent Psychiatry Community Partnership Unit (A.I.), Nagasaki University Hospital; Department of Cell Pathology (Y.K.), Graduate School of Medical Sciences, Kumamoto University; and Department of Clinical Psychology, Faculty of Medicine (N.K.), Kagawa University, Takamatsu, Japan.

Objective: To identify genes related to normal-pressure hydrocephalus (NPH) in one Japanese family with several members with NPH.

Methods: We performed whole-exome sequencing (WES) on a Japanese family with multiple individuals with NPH and identified a candidate gene. Then we generated knockout mouse using CRISPR/Cas9 to confirm the effect of the candidate gene on the pathogenesis of hydrocephalus. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007505DOI Listing
April 2019
1 Read

Hydrocephalus-induced neurogenic stunned myocardium and cardiac arrest in a child: completely reversed with CSF diversion.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

Neurogenic stunned myocardium (NSM) is a potentially fatal cause of sudden cardiogenic dysfunction due to an acute neurological event, most commonly aneurysmal subarachnoid hemorrhage in adults. Only two pediatric cases of hydrocephalus-induced NSM have been reported. Here the authors report a third case in a 14-year-old boy who presented with severe headache, decreased level of consciousness, and shock in the context of acute hydrocephalus secondary to fourth ventricular outlet obstruction 3 years after standard-risk medulloblastoma treatment. Read More

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http://dx.doi.org/10.3171/2019.2.PEDS18711DOI Listing

Commentary: Predicting Cognitive Improvement in Normal Pressure Hydrocephalus Patients Using Preoperative Neuropsychological Testing and Cerebrospinal Fluid Biomarkers.

Neurosurgery 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurology, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1093/neuros/nyz111DOI Listing

Perception of Verticality and Vestibular Disorders of Balance and Falls.

Front Neurol 2019 3;10:172. Epub 2019 Apr 3.

German Center for Vertigo and Balance Disorders, Ludwig-Maximilians University, Munich, Germany.

To review current knowledge of the perception of verticality, its normal function and disorders. This is based on an integrative graviceptive input from the vertical semicircular canals and the otolith organs. The special focus is on human psychophysics, neurophysiological and imaging data on the adjustments of subjective visual vertical (SVV) and the subjective postural vertical. Read More

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http://dx.doi.org/10.3389/fneur.2019.00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457206PMC

Susceptibility Weighted Imaging (SWI) Recommended as a Regular Magnetic Resonance Diagnosis for Vascular Dementia to Identify Independent Idiopathic Normal Pressure Hydrocephalus Before Ventriculo-Peritoneal (V-P) Shunt Treatment: A Case Study.

Front Neurol 2019 29;10:262. Epub 2019 Mar 29.

Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.

Idiopathic normal pressure hydrocephalus (INPH) with comorbid vascular dementia (VD) often have poor response to ventriculo-peritoneal (V-P) shunt. Here, three patients over the age of 60 came to the hospital with the similar clinical symptoms, Evan index over 0.3, mini-mental state examination (MMSE) score <27, and cerebrospinal fluid (CSF) pressure under 200 mmHO. Read More

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http://dx.doi.org/10.3389/fneur.2019.00262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449466PMC
March 2019
1 Read

Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury.

Clin Chem Lab Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Background Brevican, neurocan, tenascin-C and tenascin-R are extracellular matrix proteins present in brain that show increased expression in experimental animal models of brain injury. However, little is known about the dynamics of these proteins in human body fluids, such as cerebrospinal fluid (CSF) and serum, after traumatic brain injury (TBI). The aims of this study were to investigate if matrix proteins in CSF and serum are associated with functional outcome following traumatic brain injury, if their concentrations change over time and to compare their levels between brain injured patients to controls. Read More

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http://dx.doi.org/10.1515/cclm-2019-0034DOI Listing

Clinical outcomes of normal pressure hydrocephalus in 116 patients: objective versus subjective assessment.

J Neurosurg 2019 Apr 12:1-7. Epub 2019 Apr 12.

2Department of Neurological Surgery, The University of Texas Southwestern Medical Center.

OBJECTIVEObjective assessment tests are commonly used to predict the response to ventriculoperitoneal (VP) shunting in patients with normal pressure hydrocephalus (NPH). Whether subjective reports of improvement after a lumbar drain (LD) trial can predict response to VP shunting remains controversial. The goal in this study was to compare clinical characteristics, complication rates, and shunt outcomes of objective and subjective LD responders who underwent VP shunt placement. Read More

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http://dx.doi.org/10.3171/2019.1.JNS181598DOI Listing

Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases.

Fluids Barriers CNS 2019 Apr 10;16(1). Epub 2019 Apr 10.

Brain Barriers Group, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Medical Sciences Building, University Drive, Callaghan, NSW, 2308, Australia.

The fine balance between the secretion, composition, volume and turnover of cerebrospinal fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance can be disrupted. A significant disruption to the normal CSF circulation can be life threatening, leading to increased intracranial pressure (ICP), and is implicated in hydrocephalus, idiopathic intracranial hypertension, brain trauma, brain tumours and stroke. Read More

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https://fluidsbarrierscns.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12987-019-0129-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456952PMC
April 2019
5 Reads

Utility of radiological variables to predict the result of lumbar infusion test in the diagnosis of idiopathic normal pressure hydrocephalus.

World Neurosurg 2019 Apr 6. Epub 2019 Apr 6.

Gerencia de Atención Primaria de Salamanca, Salamanca, Salamanca, Spain.

Background: Diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is based in clinical data, radiological variables and invasive cerebrospinal fluid (CSF) testing, such the lumbar infusion test. Several neuroimaging findings are inconclusively related with improvement after CSF shunt surgery. On the other hand, the CSF tests are annoying for the patients and have complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193100
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http://dx.doi.org/10.1016/j.wneu.2019.04.009DOI Listing
April 2019
1 Read

Changes in brain morphology in patients in the preclinical stage of idiopathic normal pressure hydrocephalus.

Psychogeriatrics 2019 Apr 5. Epub 2019 Apr 5.

Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan.

Background: Specific ventriculomegaly features, including tight high-convexity and medial subarachnoid spaces, are found on magnetic resonance images in patients with idiopathic normal pressure hydrocephalus (iNPH). However, some healthy elderly individuals with no typical triad symptoms of iNPH also exhibit specific magnetic resonance image features of iNPH. Therefore, this study quantitatively clarified the brain morphology of suspected iNPH patients with no objective triad symptoms (iNPH-NOS). Read More

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http://dx.doi.org/10.1111/psyg.12445DOI Listing

The Aging Vestibular System: Dizziness and Imbalance in the Elderly.

Authors:
Klaus Jahn

Adv Otorhinolaryngol 2019 15;82:143-149. Epub 2019 Jan 15.

Aging in vestibular structures with loss of hair cells in the inner ear starts early in life, but vestibular function usually remains relatively unimpaired up to advanced ages. However, dizziness and imbalance are common in the elderly and have substantial impact on the quality of life. Dizziness interferes with the everyday activities of 30% of persons over age 70. Read More

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http://dx.doi.org/10.1159/000490283DOI Listing
January 2019
3 Reads

Predicting Cognitive Improvement in Normal Pressure Hydrocephalus Patients Using Preoperative Neuropsychological Testing and Cerebrospinal Fluid Biomarkers.

Neurosurgery 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurological Surgery, Columbia University Medical Center, New York, New York.

Background: Though it is well known that normal pressure hydrocephalus (NPH) patients can cognitively improve after ventriculoperitoneal shunting (VPS), one of the major dilemmas in NPH is the ability to prospectively predict which patients will improve.

Objective: To prospectively assess preoperative predictors of postshunt cognitive improvement.

Methods: This was a prospective observational cohort including 52 consecutive patients with approximately 1-yr follow-up. Read More

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http://dx.doi.org/10.1093/neuros/nyz102DOI Listing
April 2019
4 Reads

Health Care Expenditures of Medicare Beneficiaries with Normal Pressure Hydrocephalus.

World Neurosurg 2019 Mar 28. Epub 2019 Mar 28.

Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address:

Background: Normal pressure hydrocephalus (NPH) is an underdiagnosed and undertreated condition affecting the elderly population and with costs associated with its surgical management reported to be less than those associated with conservative management.

Objective: To determine if the rate of diagnosis of NPH has improved over the last decade, the rate of treatment has increased, and if surgical treatment costs and socioeconomic factors related to receipt of treatment have changed over time compared with conservative therapy.

Methods: A retrospective study based on data from a nationally representative random sample of 2,378,637 Medicare beneficiaries (2006-2010) was performed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.201DOI Listing
March 2019
1 Read
2.417 Impact Factor

Cerebral blood flow and Alzheimer's disease-related biomarkers in cerebrospinal fluid in idiopathic normal pressure hydrocephalus.

Psychogeriatrics 2019 Mar 27. Epub 2019 Mar 27.

Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan.

Aim: Alzheimer's disease (AD) pathology is highly prevalent in patients with idiopathic normal pressure hydrocephalus (iNPH), and the presence of AD pathology may involve regional cerebral blood flow (rCBF). In this study, we examined the relationship between rCBF and AD-related biomarkers in the cerebrospinal fluid of iNPH patients.

Methods: Patients with iNPH (n = 39) were classified into groups with (iNPH/AD+) (n=15) and without (iNPH/AD-) (n=24) high biomarker probability of AD (i. Read More

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http://dx.doi.org/10.1111/psyg.12435DOI Listing
March 2019
1 Read

Are gait changes linked to CSF flow changes in the sagittal sinus?

Neuroradiology 2019 Mar 26. Epub 2019 Mar 26.

Faculty of Health and Medicine, The University of Newcastle, Newcastle, Australia.

Purpose: To identify if specific findings on magnetic resonance imaging (MRI) cerebrospinal fluid (CSF) flow studies can be utilised to identify which patients with idiopathic normal pressure hydrocephalus (iNPH) will have improved gait following a CSF tap test (TT).

Methods: Prospective study of patients undergoing a CSF TT for iNPH. Functional gait was assessed using the timed up and go (TUG) test before and after the CSF TT. Read More

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http://dx.doi.org/10.1007/s00234-019-02192-2DOI Listing

Current epidemiology of cerebrospinal fluid shunt surgery in the UK and Ireland (2004-2013).

J Neurol Neurosurg Psychiatry 2019 Mar 25. Epub 2019 Mar 25.

Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Objectives: To determine current epidemiology and clinical characteristics of cerebrospinal fluid (CSF) shunt surgery, including revisions.

Methods: A retrospective, multicentre, registry-based study was conducted based on 10 years' data from the UK Shunt Registry, including primary and revision shunting procedures reported between 2004 and 2013. Incidence rates of primary shunts, descriptive statistics and shunt revision rates were calculated stratified by age group, geographical region and year of operation. Read More

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-319927
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http://dx.doi.org/10.1136/jnnp-2018-319927DOI Listing
March 2019
9 Reads

Hydrocephalus in a Patient with Alzheimer's Disease.

Dement Neurocogn Disord 2018 Mar 26;17(1):32-36. Epub 2018 Mar 26.

Department of Neurology, Wonkwang University School of Medicine, Iksan, Korea.

Background: Normal pressure hydrocephalus (NPH) is an etiology of dementia that is reversible following cerebrospinal fluid shunt placement, however, surgical intervention not always clinically effective and the respons to shunt therapy is poorly understood. Furthermore, NPH is a source of comorbidity in diseases with neurodegenerative pathology, such as Alzheimer's disease (AD).

Case Report: A 61-year-old woman presented to the neurology clinic with progressive gait difficulties and cognitive impairment over five years. Read More

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http://dx.doi.org/10.12779/dnd.2018.17.1.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427995PMC

Ventriculoperitoneal Shunting in Alobar Holoprosencephaly: Does it Work Even When Patient Has No Sign of Raised Intracranial Pressure?

J Craniofac Surg 2019 Mar 19. Epub 2019 Mar 19.

Liv Hospital, Department of Neurosurgery, Ankara, Turkey.

Holoprosencephaly (HPE) is a developmental anomaly of forebrain characterized by a failure of division of the embryonic forebrain into hemispheres. It is associated with a set of facial anomalies at a rate of 80%. Survival rate, particularly in alobar HPE, is quite low. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005432DOI Listing
March 2019
1 Read

Focused Ultrasound Thalamotomy for Essential Tremor in the Setting of a Ventricular Shunt: Technical Report.

Oper Neurosurg (Hagerstown) 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: A recent randomized controlled trial of magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) for essential tremor (ET) demonstrated safety and efficacy. Patients with ventricular shunts may be good candidates for FUS to minimize hardware-associated infections.

Objective: To demonstrate feasibility of FUS in this subset of patients. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opz013DOI Listing
March 2019
3 Reads

Revisiting the Cerebrospinal Fluid Biomarker Profile in Idiopathic Normal Pressure Hydrocephalus: The Bologna Pro-Hydro Study.

J Alzheimers Dis 2019 ;68(2):723-733

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Cerebrospinal fluid (CSF) biomarkers have been extensively investigated in idiopathic normal pressure hydrocephalus (iNPH) with the aim of a better differential diagnosis, but the pathophysiological mechanisms underlying CSF biomarker changes and the relationship between biomarker levels and clinical variables are still a matter of debate. We evaluated CSF amyloid-β (Aβ)42 and Aβ40, total (t)-tau, phosphorylated (p)-tau, total prion protein (t-PrP), and neurofilament light chain protein (NfL) in healthy controls (n = 50) and subjects with iNPH (n = 71), Alzheimer's disease (AD) (n = 60), and several other subtypes of dementia (n = 145). Patients with iNPH showed significantly lower levels of Aβ42, Aβ40, t-tau, and p-tau compared to controls. Read More

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http://dx.doi.org/10.3233/JAD-181012DOI Listing
January 2019
1 Read

Background Risk Factors Associated with Shunt Intervention for Possible Idiopathic Normal Pressure Hydrocephalus: A Nationwide Hospital-Based Survey in Japan.

J Alzheimers Dis 2019 ;68(2):735-744

Department of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.

Background: Patients with idiopathic normal-pressure hydrocephalus (iNPH) are typically older adults with multiple comorbidities that are associated with a reduction in the efficacy of iNPH treatment via cerebrospinal fluid (CSF) shunt placement.

Objective: The present study aimed to investigate the effectiveness of CSF shunt for iNPH using data from a nationwide epidemiological survey in Japan.

Methods: We examined 1,423 patients (581 women) aged ≥60 years (median age [25%-75%]: 77 [73-80] years) who were diagnosed with iNPH following a hospital visit in 2012. Read More

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http://dx.doi.org/10.3233/JAD-180955DOI Listing
January 2019
2 Reads

Treatment of normal pressure hydrocephalus resolves dorsal midbrain syndrome.

Neurol Sci 2019 Mar 16. Epub 2019 Mar 16.

Department of Neurology, University of Pittsburgh Medical Center Hamot, 201 State Street, Erie, PA, 16550, USA.

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http://dx.doi.org/10.1007/s10072-019-03841-3DOI Listing
March 2019
1 Read

Comparison of Complication and Revision Rates After Frontal Versus Parietal Approach for Ventricular Shunt Placement in Idiopathic Normal Pressure Hydrocephalus.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA; Department of Bioengineering, Mayo Clinic, Rochester, Minnesota, USA; Department of Orthopedics, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Background: Ventricular shunts are most commonly placed via a frontal or parietal approach. However, there is a paucity of data comparing complication and revision rates associated with these approaches in the idiopathic normal pressure hydrocephalus (iNPH) population.

Methods: Patients with iNPH treated with ventricular shunting between 2001 and 2017 at our institution were included for analysis. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.027DOI Listing

Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus.

Dement Geriatr Cogn Disord 2019 Mar 12;47(1-2):91-103. Epub 2019 Mar 12.

Department of Neurosurgery, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.

Background/aims: The C9ORF72 expansion is known to cause frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). We aim to identify the prevalence of the C9ORF72 expansion in idiopathic normal pressure hydrocephalus (iNPH).

Methods: We analysed the C9ORF72 expansion in a large cohort of patients with possible iNPH (n = 487) and cognitively intact elderly controls (n = 432; age > 65 years). Read More

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https://www.karger.com/Article/FullText/497306
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http://dx.doi.org/10.1159/000497306DOI Listing
March 2019
4 Reads

25 Ventriculoperitoneal Shunt as a Meteorologist: Medtronics Shunt Headaches Vaticinating Climatic Perturbation.

CNS Spectr 2019 Feb;24(1):186-187

5Neuropsychiatrist,Smell & Taste Treatment and Research Foundation,Chicago,IL.

IntroductionNeurological conditions can be influenced by meteorological parameters. Some may predict weather changes, such as migraines [Marrelli 1988], burning mouth syndrome [Hirsch 2017], phantosmia [Hirsch 2013], and Bell's Palsy [Danielides 2001]. However, climatic conditions inducing headaches in those with ventriculoperitoneal shunt (VPS) placements have not heretofore been described. Read More

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http://dx.doi.org/10.1017/S1092852919000191DOI Listing
February 2019
2 Reads

Asymmetry Index in Muscle Activations.

IEEE Trans Neural Syst Rehabil Eng 2019 Apr 7;27(4):772-779. Epub 2019 Mar 7.

Gait asymmetry is typically evaluated using spatio-temporal or joint kinematics parameters. Only a few studies addressed the problem of defining an asymmetry index directly based on muscle activity, extracting parameters from surface electromyography (sEMG) signals. Moreover, no studies used the extraction of the muscle principal activations (activations that are necessary for accomplishing a specific motor task) as the base to construct an asymmetry index, less affected by the variability of sEMG patterns. Read More

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https://ieeexplore.ieee.org/document/8662716/
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http://dx.doi.org/10.1109/TNSRE.2019.2903687DOI Listing
April 2019
7 Reads

Snap-valve cerebral shunt design for intracranial pressure operation and ultrasound visualization.

Med Eng Phys 2019 Apr 1;66:1-11. Epub 2019 Mar 1.

Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, United States. Electronic address:

Cerebral spinal fluid (CSF) shunts are the main treatment for hydrocephalus. They divert excess CSF from the ventricular system to the abdominal, pleural, or intravascular space where it is absorbed. The shunt valve regulates flow based on intracranial pressure (ICP) to maintain a physiologically stable and safe ICP. Read More

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http://dx.doi.org/10.1016/j.medengphy.2018.12.024DOI Listing
April 2019
1 Read

Optic disc cupping characteristics of normal pressure hydrocephalus patients with normal-tension glaucoma.

Sci Rep 2019 Feb 28;9(1):3108. Epub 2019 Feb 28.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

We examined the potential association of idiopathic normal pressure hydrocephalus (iNPH) with the generation of normal-tension glaucoma (NTG), to explore possible relationships between intracranial pressure (ICP) and the presence of glaucoma, and to compare disc morphology of NTG patients with or without iNPH. We investigated 20 iNPH patients, examined the prevalence of glaucoma, and compared the optic discs of NTG patients with iNPH (n = 11) and age-matched NTG patients without iNPH (n = 16). All data were collected prior to the treatment of iNPH, to eliminate the possibility that the treatment may have contributed to the progression of NTG. Read More

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http://dx.doi.org/10.1038/s41598-019-39526-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395590PMC
February 2019
1 Read

Aqueductal CSF Stroke Volume Is Increased in Patients with Idiopathic Normal Pressure Hydrocephalus and Decreases after Shunt Surgery.

AJNR Am J Neuroradiol 2019 Mar 21;40(3):453-459. Epub 2019 Feb 21.

Neuroscience and Neurology (J.V.), Uppsala University, Uppsala, Sweden

Background And Purpose: Increased CSF stroke volume through the cerebral aqueduct has been proposed as a possible indicator of positive surgical outcome in patients with idiopathic normal pressure hydrocephalus; however, consensus is lacking. In this prospective study, we aimed to compare CSF flow parameters in patients with idiopathic normal pressure hydrocephalus with those in healthy controls and change after shunt surgery and to investigate whether any parameter could predict surgical outcome.

Materials And Methods: Twenty-one patients with idiopathic normal pressure hydrocephalus and 21 age- and sex-matched healthy controls were prospectively included and examined clinically and with MR imaging of the brain. Read More

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http://dx.doi.org/10.3174/ajnr.A5972DOI Listing

Natural history of ventriculomegaly in adults: a cluster analysis.

J Neurosurg 2019 Feb 8:1-8. Epub 2019 Feb 8.

OBJECTIVEChronic ventriculomegaly in the absence of raised intracranial pressure (ICP) is a known entity in adult hydrocephalus practice. The natural history and indication for treatment is, however, poorly defined. A highly heterogeneous group, some adults with ventriculomegaly are asymptomatic, while others have life-threatening deteriorations. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18119DOI Listing
February 2019
4 Reads

Long-Term Effect of Decompressive Craniectomy on Intracranial Pressure and Possible Implications for Intracranial Fluid Movements.

Neurosurgery 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.

Background: Decompressive craniectomy (DC) is used in cases of severe intracranial hypertension or impending intracranial herniation. DC effectively lowers intracranial pressure (ICP) but carries a risk of severe complications related to abnormal ICP and/or cerebrospinal fluid (CSF) circulation, eg, hygroma formation, hydrocephalus, and "syndrome of the trephined."

Objective: To study the long-term effect of DC on ICP, postural ICP regulation, and intracranial pulse wave amplitude (PWA). Read More

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http://dx.doi.org/10.1093/neuros/nyz049DOI Listing
February 2019
1 Read

Structure and function of proprotein convertase subtilisin/kexin type 9 (PCSK9) in atherosclerosis.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214141626DOI Listing
February 2019
1 Read
3.021 Impact Factor

Recent advances in rational diagnosis and treatment of normal pressure hydrocephalus: A critical appraisal on novel diagnostic, therapy monitoring and treatment modalities.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214121342DOI Listing
February 2019
4 Reads
3.021 Impact Factor

Hemodynamically self-corrected ΔADC analysis in idiopathic normal pressure hydrocephalus.

Br J Radiol 2019 May 27;92(1097):20180553. Epub 2019 Feb 27.

1 Department of Radiology, Kouseiren Takaoka Hospital , Takaoka, Toyama , Japan.

Objective: To clarify the cause of higher water fluctuation of the brain in idiopathic normal pressure hydrocephalus (iNPH), we assessed change in hemodynamic-independent apparent diffusion coefficient during the cardiac cycle (ΔADC) in iNPH.

Methods: Electrocardiographically synchronized single-shot diffusion echo-planer imaging ( = 0, 500, and 1000 s/mm) was performed in healthy volunteers, atrophic ventricular dilation group, and iNPH group, respectively. The ΔADC ( = 0 and 1000 s/mm) and maximum ADC ( = 0 and 500 s/mm) in the cardiac cycles were measured at the frontal white matter in the brain. Read More

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http://dx.doi.org/10.1259/bjr.20180553DOI Listing
May 2019
1 Read

Comorbidity of diabetes mellitus in idiopathic normal pressure hydrocephalus: a systematic literature review.

Fluids Barriers CNS 2019 Feb 12;16(1). Epub 2019 Feb 12.

Department of Neurosurgery, Wayne State University, 51 W Palmer ave, Detroit, MI, 48202, USA.

Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of hydrocephalus that occurs more often in the elderly population. It is usually characterized by gait disturbance, dementia and urinary incontinence. Epidemiological studies indicate that 15. Read More

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https://fluidsbarrierscns.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12987-019-0125-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371499PMC
February 2019
8 Reads

Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus versus Alzheimer's Disease and Subcortical Ischemic Vascular Disease: A Systematic Review.

J Alzheimers Dis 2019 ;68(1):267-279

Department of Neurology, Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen OE, Denmark.

Background: The diagnostic workup of idiopathic normal pressure hydrocephalus (iNPH) can be challenging due to an overlap in symptoms and neuroimaging features with other disorders. Despite a growing interest, a cerebrospinal fluid (CSF) biomarker profile in iNPH has not yet been identified.

Objective: To determine the CSF biomarkers with the greatest evidence for differentiating iNPH from the most common differential diagnoses, Alzheimer's disease (AD) and subcortical ischemic vascular disease (SIVD). Read More

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http://dx.doi.org/10.3233/JAD-180816DOI Listing
January 2019
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The Computerized General Neuropsychological INPH Test revealed improvement in idiopathic normal pressure hydrocephalus after shunt surgery.

J Neurosurg 2019 Feb 8:1-8. Epub 2019 Feb 8.

2Department of Pharmacology and Clinical Neuroscience.

OBJECTIVEThe Computerized General Neuropsychological INPH Test (CoGNIT) provides the clinician and the researcher with standardized and accessible cognitive assessments in patients with idiopathic normal pressure hydrocephalus (INPH). CoGNIT includes tests of memory, executive functions, attention, manual dexterity, and psychomotor speed. Investigations of the validity and reliability of CoGNIT have been published previously. Read More

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http://dx.doi.org/10.3171/2018.10.JNS18701DOI Listing
February 2019

Dynamic Balance Measurements Can Differentiate Patients Who Fall From Patients Who Do Not Fall in Patients With Idiopathic Normal Pressure Hydrocephalus.

Arch Phys Med Rehabil 2019 Feb 4. Epub 2019 Feb 4.

Department of Physical and Rehabilitation Medicine, Division of Comprehensive Medicine, Osaka Medical College, Osaka, Japan.

Objectives: To investigate which clinical assessments are suitable for differentiating patients who fall from patients who do not fall in patients with idiopathic normal pressure hydrocephalus (iNPH).

Design: Prospective observational study.

Setting: Osaka Medical College Hospital. Read More

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http://dx.doi.org/10.1016/j.apmr.2019.01.008DOI Listing
February 2019
2 Reads

Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections.

J Infect Dis 2019 Feb 5. Epub 2019 Feb 5.

Centre for Individualized Infection Medicine, Hannover, Germany.

Background: The tryptophan-kynurenine-NAD+ pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in CNS infections would improve our understanding of pathophysiology and end-organ damage, and, furthermore, open doors to its evaluation as a source of diagnostic and/or prognostic biomarkers.

Methods: We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 220 cerebrospinal fluid samples from patients with bacterial and viral (herpes simplex, varicella zoster, enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (anti-NMDA-R encephalitis, multiple sclerosis), and noninflamed controls (Bell's palsy, normal pressure hydrocephalus, Tourette syndrome). Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz048DOI Listing
February 2019
10 Reads

Normal Pressure Hydrocephalus.

Continuum (Minneap Minn) 2019 Feb;25(1):165-186

Purpose Of Review: Since it was first described in 1965, normal pressure hydrocephalus (NPH) has been a controversial subject. New studies have shed light on its epidemiology and pathogenesis and provided objective ways to measure outcome in patients with NPH. Neuroimaging has improved and allows better recognition of both NPH and the presence of overlapping diseases RECENT FINDINGS: Several recent epidemiologic studies confirm that NPH is a rare disease, but the presence of large ventricles is a common finding with aging. Read More

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http://dx.doi.org/10.1212/CON.0000000000000689DOI Listing
February 2019
11 Reads

Quantitative Evaluation of Gait Disturbance on an Instrumented Timed Up-and-go Test.

Aging Dis 2019 Feb 1;10(1):23-36. Epub 2019 Feb 1.

1Normal Pressure Hydrocephalus Center, Rakuwakai Otowa Hospital, Rakuwakai Healthcare System, Kyoto, Japan.

Although the 3-m timed up-and-go test (TUG) is reliable for evaluating mobility, TUG time is insufficient to evaluate mild gait disturbance; we, therefore aimed to investigate other measurements with instrumented TUG (iTUG) using a free smartphone application. Our inclusion criterion in this study is only that participants can walk without any assistance. This study included three heterogeneous groups; patients who underwent a tap test or shunt surgery, 29 inpatients hospitalized for other reasons, and 87 day-care users. Read More

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http://dx.doi.org/10.14336/AD.2018.0426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345343PMC
February 2019
1 Read

Considerations for Patients With Idiopathic Normal Pressure Hydrocephalus Undergoing Cardiac Surgery.

J Cardiothorac Vasc Anesth 2019 04 14;33(4):1176-1178. Epub 2018 Nov 14.

Department of Cardiac Surgery, Athens Medical Center, Athens, Greece.

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http://dx.doi.org/10.1053/j.jvca.2018.11.008DOI Listing
April 2019
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[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-β Load in Subjects Examined for Normal Pressure Hydrocephalus.

J Alzheimers Dis 2019 ;67(4):1343-1351

Institute of Clinical Medicine, Neurosurgery, University of Eastern Finland, Kuopio, Finland.

Background: Idiopathic normal pressure hydrocephalus (iNPH) is frequently associated with concomitant amyloid-β (Aβ) pathology.

Objective: To compare the [11C]PIB PET uptake in the patients with suspected iNPH to Aβ and hyperphosphorylated-tau (HPτ) in the right frontal cortical biopsy, the cerebrospinal fluid (CSF) Aβ, the response to a CSF shunt, and the final clinical diagnosis of Alzheimer's disease (AD).

Methods: Patients (n = 21) from Kuopio NPH Registry (http://www. Read More

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http://dx.doi.org/10.3233/JAD-180645DOI Listing
January 2019
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DTI Profiles for Rapid Description of Cohorts at the Clinical-Research Interface.

Front Med (Lausanne) 2018 10;5:357. Epub 2019 Jan 10.

Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.

Normal pressure hydrocephalus (NPH) is a syndrome comprising gait disturbance, cognitive decline and urinary incontinence that is an unique model of reversible brain injury, but it presents as a challenging spectrum of disease cohorts. Diffusion Tensor Imaging (DTI), with its ability to interrogate structural white matter patterns at a microarchitectural level, is a potentially useful tool for the confirmation and characterization of disease cohorts at the clinical-research interface. However, obstacles to its widespread use involve the need for consistent DTI analysis and interpretation tools across collaborator sites. Read More

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http://dx.doi.org/10.3389/fmed.2018.00357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335243PMC
January 2019
1 Read

Gait analysis in a component timed-up-and-go test using a smartphone application.

J Neurol Sci 2019 Mar 16;398:45-49. Epub 2019 Jan 16.

Digital Standard Co., Ltd., 2-6-24 Sonezakishinchi, Kita-ku, Osaka, Japan. Electronic address:

Background: The timed-up-and-go test (TUG) is a popular test for mobility, but it only measures the total time to complete tasks. Recent advances in smartphone technology enables measuring respective times of 6 components in the test (Stand, Go, Turn1, Come, Turns and Sit). We examined availability of these data for assessing different gait patterns. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.023DOI Listing

A prospective study on gait dominant normal pressure hydrocephalus.

Acta Neurol Scand 2019 Apr 19;139(4):389-394. Epub 2019 Feb 19.

Barrow Neurological Institute, Dignity Health Organization, St. Joseph Hospital and Medical Center, Phoenix, Arizona.

Object: We characterize idiopathic normal pressure hydrocephalus (NPH) following treatment with lumbar puncture (LP) and shunt placement through clinical evaluation and quantitative ProtoKinetics Zeno walkway assessments. We evaluate the symptomology by determining gait characteristics altered by treatment.

Methods: Patients at Barrow Neurological Institute (BNI) who underwent a LP, removing 30-32 mL cerebrospinal fluid) followed by ventriculoperitoneal shunt placement in February 2015 to February 2017 were analyzed for gait impairments. Read More

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http://dx.doi.org/10.1111/ane.13064DOI Listing
April 2019
2 Reads

Opposing CSF hydrodynamic trends found in the cerebral aqueduct and prepontine cistern following shunt treatment in patients with normal pressure hydrocephalus.

Fluids Barriers CNS 2019 Jan 22;16(1). Epub 2019 Jan 22.

Neural Systems and Dynamics Laboratory, Department of Neurosurgery, The David Geffen School of Medicine, University of California-Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.

Background: This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the prepontine cistern between three distinct groups: pre-shunt normal pressure hydrocephalus (NPH) patients, post-shunt NPH patients, and controls. We hypothesized that the hyperdynamic flow of CSF through the cerebral aqueduct seen in NPH patients was due to a reduction in cisternal CSF volume buffering. Both hydrodynamic (velocity, flow, stroke volume) and peak flow latency (PFL) parameters were investigated. Read More

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http://dx.doi.org/10.1186/s12987-019-0122-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341759PMC
January 2019
1 Read

Location-specific characteristics of perivascular spaces as the brain's interstitial fluid drainage system.

J Neurol Sci 2019 Mar 16;398:9-15. Epub 2019 Jan 16.

Interfaculty Initiative in Information Studies / Institute of Industrial Science, The University of Tokyo, Tokyo, Japan. Electronic address:

Purpose: Brain interstitial fluid plays an important role in the excretion of metabolic waste products into the cerebrospinal fluid through perivascular spaces (PVS). To investigate the normal function of PVS in healthy elderly individuals, we assessed the relationship between PVS and white matter hyperintensity (WMH) on MRI in two locations.

Methods: This study included 296 healthy individuals aged ≥60 years without a history of brain disease who underwent brain MRI. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.022DOI Listing
March 2019
2 Reads

Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis.

Int J Mol Sci 2019 Jan 15;20(2). Epub 2019 Jan 15.

Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Enteroviruses are among the most common causes of viral meningitis. Enteroviral meningitis continues to represent diagnostic challenges, as cerebrospinal fluid (CSF) cell numbers (a well validated diagnostic screening tool) may be normal in up to 15% of patients. We aimed to identify potential CSF biomarkers for enteroviral meningitis, particularly for cases with normal CSF cell count. Read More

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http://dx.doi.org/10.3390/ijms20020337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359617PMC
January 2019
4 Reads