3,558 results match your criteria Normal Pressure Hydrocephalus


Meningeal carcinomatosis presenting with leukoencephalopathy-like imaging findings.

eNeurologicalSci 2019 Mar 19;14:21-23. Epub 2018 Nov 19.

Department of Neurology, University of Tsukuba, 1-1-1 Tenodai, Tsukuba-city, Japan.

Meningeal carcinomatosis is a unique and rare form of metastasis observed in patients with malignant tumours. Diagnosis is simple when the primary lesion of the malignant tumour is clear, and when multiple miliary lesions are confirmed via cranial contrast MRI; however, many patients exhibit atypical imaging findings. In the present report, we discuss the case of a 72-year-old man who presented with subacute consciousness impairment and MRI findings suggestive of progressive, bilateral leukoencephalopathy-like lesions around the ventricles. Read More

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http://dx.doi.org/10.1016/j.ensci.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275227PMC

Absence of Disproportionately Enlarged Subarachnoid Space Hydrocephalus, a Sharp Callosal Angle, or Other Morphologic MRI Markers Should Not Be Used to Exclude Patients with Idiopathic Normal Pressure Hydrocephalus from Shunt Surgery.

AJNR Am J Neuroradiol 2018 Dec 6. Epub 2018 Dec 6.

From the Hydrocephalus Research Unit (S.A., M.W., P.H., C.W., M.T.), Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology.

Background And Purpose: Several studies have evaluated the use of MR imaging markers for the prediction of outcome after shunt surgery in idiopathic normal pressure hydrocephalus with conflicting results. Our aim was to investigate the predictive value of a number of earlier proposed morphologic MR imaging markers in a large group of patients with idiopathic normal pressure hydrocephalus.

Materials And Methods: One hundred sixty-eight patients (mean age, 70 ± 9. Read More

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http://dx.doi.org/10.3174/ajnr.A5910DOI Listing
December 2018

Deep Brain Stimulation Surgery for Parkinson Disease Coexisting With Communicating Hydrocephalus: A Case Report.

Front Neurol 2018 23;9:1011. Epub 2018 Nov 23.

Hospital Clínico, Universidad de Chile, Santiago, Chile.

We report a successful bilateral globus pallidus internus-deep brain stimulation (GPi-DBS) for a Parkinson disease (PD) patient with idiopathic normal pressure hydrocephalus (INPH) and an unusually long anterior commissure-posterior commissure (AC-PC) line. A 54-year-old man presented with a history of 3 months of severe shuffling gait, rigidity, slow movements of the left side limbs, and difficulty managing finances. A brain MRI revealed marked ventriculomegaly (Evans index = 0. Read More

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http://dx.doi.org/10.3389/fneur.2018.01011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265407PMC
November 2018
1 Read

Cord Compression Caused by a Tangled and Warped Lumbar Catheter After Lumboperitoneal Shunt Placement.

Neurospine 2018 Oct 2. Epub 2018 Oct 2.

Department of Neurosurgery, Tohoku University, Graduate School of Medicine, Sendai, Japan.

The present study reports the case of an 81-year-old woman who underwent lumboperitoneal shunt (LPS) placement for idiopathic normal-pressure hydrocephalus. After LPS placement, the patient presented with radicular pain. A computed tomography scan revealed that the intradural lumbar catheter was tangled at the T11 vertebra; therefore, we decided to remove the catheter under local anesthesia. Read More

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http://e-neurospine.org/journal/view.php?doi=10.14245/ns.183
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http://dx.doi.org/10.14245/ns.1836114.057DOI Listing
October 2018
1 Read

Abnormal Gray Matter Structural Networks in Idiopathic Normal Pressure Hydrocephalus.

Front Aging Neurosci 2018 15;10:356. Epub 2018 Nov 15.

Department of Radiology, Huashan Hospital of Fudan University, Shanghai, China.

: Idiopathic normal pressure hydrocephalus (iNPH) is known as a treatable form of dementia. Network analysis is emerging as a useful method to study neurological disorder diseases. No study has examined changes of structural brain networks of iNPH patients. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249342PMC
November 2018
1 Read

Automated detection of imaging features of disproportionately enlarged subarachnoid space hydrocephalus using machine learning methods.

Neuroimage Clin 2018 Nov 19. Epub 2018 Nov 19.

Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.

Objective: Create an automated classifier for imaging characteristics of disproportionately enlarged subarachnoid space hydrocephalus (DESH), a neuroimaging phenotype of idiopathic normal pressure hydrocephalus (iNPH).

Methods: 1597 patients from the Mayo Clinic Study of Aging (MCSA) were reviewed for imaging characteristics of DESH. One core feature of DESH, the presence of tightened sulci in the high-convexities (THC), was used as a surrogate for the presence of DESH as the expert clinician-defined criterion on which the classifier was trained. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.11.015DOI Listing
November 2018
2 Reads

Accuracy and safety of 1-day external lumbar drainage of CSF for shunt selection in patients with idiopathic normal pressure hydrocephalus.

Authors:

J Neurosurg 2018 Nov 1:1-7. Epub 2018 Nov 1.

OBJECTIVEThree to five days of external lumbar drainage (ELD) of CSF is a test for ventriculoperitoneal shunt (VPS) selection in idiopathic normal pressure hydrocephalus (iNPH). The accuracy and complication rates of a shorter (1-day) ELD procedure were analyzed.METHODSData of patients with iNPH who underwent 1-day ELD to be selected to undergo VPS placement with a programmable valve in the period from 2005 to 2015 were reviewed. Read More

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http://dx.doi.org/10.3171/2018.6.JNS18400DOI Listing
November 2018
1 Read

Outcomes and complications of different surgical treatments for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis.

Authors:

J Neurosurg 2018 Nov 1:1-13. Epub 2018 Nov 1.

OBJECTIVEDifferent CSF diversion procedures (ventriculoperitoneal, ventriculoatrial, and lumboperitoneal shunting) have been utilized for the treatment of idiopathic normal pressure hydrocephalus. More recently, endoscopic third ventriculostomy has been suggested as a reasonable alternative in some studies. The purpose of this study was to perform a systematic review and meta-analysis to assess overall rates of favorable outcomes and adverse events for each of these treatments. Read More

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http://dx.doi.org/10.3171/2018.5.JNS1875DOI Listing
November 2018
1 Read

Comparison of the CSF dynamics between patients with idiopathic normal pressure hydrocephalus and healthy volunteers.

Authors:

J Neurosurg 2018 Nov 1:1-6. Epub 2018 Nov 1.

OBJECTIVEIntracranial pressure (ICP), outflow resistance (Rout), and amplitude of cardiac-related ICP pulsations (AMPs) are established parameters to describe the CSF hydrodynamic system and are assumed, but not confirmed, to be disturbed in idiopathic normal pressure hydrocephalus (INPH). The aim of this study was to compare the CSF hydrodynamic profile between patients with INPH and healthy volunteers.METHODSSixty-two consecutive INPH patients (mean age 74 years) and 40 healthy volunteers (mean age 70 years) were included. Read More

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http://dx.doi.org/10.3171/2018.5.JNS173170DOI Listing
November 2018
1 Read

An elderly patient with Alzheimer's Disease, Normal Pressure Hydrocephalus and Traumatic Brain Injury: presented with behavioral symptoms similar to behavioral variant Frontotemporal Dementia.

Int J Neurosci 2018 Nov 26:1-8. Epub 2018 Nov 26.

a Department of Geriatric Medicine , Dokuz Eylul University , Faculty of Medicine , Izmir , Turkey.

Traumatic brain injury (TBI) is nondegenerative insult to brain from external mechanical forces. It may cause cognitive impairment, psychological problems in the long period. Besides traumatic brain injury also induces neuroinflammation and neurodegeneration process, and increases risk of dementia. Read More

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http://dx.doi.org/10.1080/00207454.2018.1552690DOI Listing
November 2018
9 Reads

Apathy and right caudate perfusion in idiopathic normal pressure hydrocephalus: a case-control study.

Int J Geriatr Psychiatry 2018 Nov 26. Epub 2018 Nov 26.

Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.

Objectives: Apathy is prevalent in patients with idiopathic normal pressure hydrocephalus (iNPH), a treatable disorder resulting from ventricular enlargement. We assessed the relationship between apathy and regional cerebral blood flow (rCBF) in patients with iNPH.

Methods: Before lumbo-peritoneal shunt surgery (LPS), 56 iNPH patients were evaluated on apathy and dysphoria subscales of the Neuropsychiatric Inventory (NPI), and were divided into 2 groups according to NPI apathy score: 15 without apathy (iNPH-APA) and 41 with apathy (iNPH+APA). Read More

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http://dx.doi.org/10.1002/gps.5038DOI Listing
November 2018

Differences in the Calculated Transvenous Pressure Drop between Chronic Hydrocephalus and Idiopathic Intracranial Hypertension.

AJNR Am J Neuroradiol 2018 Nov 22. Epub 2018 Nov 22.

Biomedical Engineering (A.R.B.), University of New South Wales, Sydney, New South Wales, Australia.

Background And Purpose: Chronic hydrocephalus is associated with dilated ventricles despite a normal intracranial pressure. In idiopathic intracranial hypertension, the ventricles are normal despite an elevated intracranial pressure. This apparent paradox has largely remained unexplained. Read More

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http://dx.doi.org/10.3174/ajnr.A5883DOI Listing
November 2018

Diffusion Tensor Imaging of the Superior Thalamic Radiation and Cerebrospinal Fluid Distribution in Idiopathic Normal Pressure Hydrocephalus.

J Neuroimaging 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurology, McGovern Medical School, University of Texas Health Science Center (UTHSC), Houston, TX (KY, CEM, ZK, OH, PES).

Background And Purpose: Ventricular enlargement in elderly raises a challenging differential diagnosis to physicians. While Alzheimer's disease is the most common form of dementia, idiopathic normal pressure hydrocephalus (iNPH) constitutes a potentially reversible syndrome. iNPH has a unique pathophysiology pertaining to cerebrospinal fluid (CSF) dynamics and periventricular white matter. Read More

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http://dx.doi.org/10.1111/jon.12581DOI Listing
November 2018
9 Reads

Structural correlates of cognitive impairment in normal pressure hydrocephalus.

Acta Neurol Scand 2018 Nov 14. Epub 2018 Nov 14.

Department of Psychiatry, University of Cambridge, Cambridge, UK.

Objectives: The pathological bases for the cognitive and neuropsychiatric symptoms in normal pressure hydrocephalus (NPH) have not been elucidated. However, the symptoms may indicate dysfunction of subcortical regions. Previously, volume reductions of subcortical deep grey matter (SDGM) structures have been observed in NPH patients. Read More

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http://doi.wiley.com/10.1111/ane.13052
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http://dx.doi.org/10.1111/ane.13052DOI Listing
November 2018
3 Reads
2.400 Impact Factor

Development of the Brazilian Portuguese version of the "Grading scale for idiopathic normal pressure hydrocephalus": cross-cultural adaptation, reliability and validity.

Arq Neuropsiquiatr 2018 Oct;76(10):692-696

Universidade de São Paulo, Hospital das Clínicas, Instituto de Psiquiatria, Divisão de Neurocirurgia Funcional, Grupo de Hidrodinâmica Cerebral, São Paulo SP, Brasil.

Objective: The current study translated to Portuguese and validated the normal pressure hydrocephalus (NPH) scale originally developed in English as the Grading Scale for Idiopathic Normal Pressure Hydrocephalus.

Methods: Following Guillemin's validation protocol, the last version of the Portuguese NPH scale was applied to 121 consecutive patients with a diagnosis of normal pressure hydrocephalus (73 men and 48 women) from the Group of Cerebral Hydrodynamics from July 2010 to March 2012.

Results: The mean age was 71. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0004-282X20180108DOI Listing
October 2018
2 Reads

EEG Resting-State Networks Responsible for Gait Disturbance Features in Idiopathic Normal Pressure Hydrocephalus.

Clin EEG Neurosci 2018 Nov 11:1550059418812156. Epub 2018 Nov 11.

1 Department of Psychiatry, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Idiopathic normal pressure hydrocephalus (iNPH) is a neuropsychiatric disease characterized by gait disturbance, cognitive dysfunction, and urinary incontinence that affects a large population of elderly people. These symptoms, especially gait disturbance, can potentially be improved by cerebrospinal fluid (CSF) drainage, which is more effective if performed at an early stage of the disease. However, the neurophysiological mechanisms of these symptoms and their recovery by CSF drainage are poorly understood. Read More

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http://journals.sagepub.com/doi/10.1177/1550059418812156
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http://dx.doi.org/10.1177/1550059418812156DOI Listing
November 2018
4 Reads

Pathogenesis of idiopathic Normal Pressure Hydrocephalus: A review of knowledge.

J Clin Neurosci 2018 Nov 5. Epub 2018 Nov 5.

Department of Neurosurgery, University of Crete, Panepistimiou, 71500 Iraklio, Greece.

Idiopathic Normal Pressure Hydrocephalus (iNPH) is a frequent neuropsychiatric entity. Clinically it is characterised by Hakim's triad: Dementia, gait disturbance and urinary incontinence. While its symptomatology is typical, the etiology and thereby physiopathology of iNPH still remain enigmatic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183119
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http://dx.doi.org/10.1016/j.jocn.2018.10.147DOI Listing
November 2018
6 Reads

Gulliver's world: Persistent lilliputian hallucinations as manifestation of Charles Bonnet syndrome in a case of cataract and normal pressure hydrocephalus.

Indian J Psychiatry 2018 Jul-Sep;60(3):358-360

Department of Psychiatry, NIMHANS, Bengaluru, Karnataka, India.

Charles Bonnet Syndrome (CBS) typically occurs in elderly people with peripheral vision impairment, or interruptions in the connections from eyes to visual cortex. The heterogeneity of presentations and causal mechanisms warrants clinical caution. In this report, we describe a case of CBS developing in the form of Lilliputian Hallucinations in an elderly gentleman, on the background of cataract and normal pressure hydrocephalus, the complexities arising out of such aetiogenesis, and its management. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_236_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201671PMC
November 2018

Letter: Lumboperitoneal Shunts for the Treatment of Idiopathic Normal Pressure Hydrocephalus: A Comparison of Small-Lumen Abdominal Catheters to Gravitational Add-On Valves in a Single Center.

Oper Neurosurg (Hagerstown) 2019 Jan;16(1):E27-E28

Department of Neurosurgery West China Hospital Sichuan University Chengdu, Sichuan, P.R. China.

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http://dx.doi.org/10.1093/ons/opy328DOI Listing
January 2019

Diffusional Kurtosis along the Corticospinal Tract in Adult Normal Pressure Hydrocephalus.

AJNR Am J Neuroradiol 2018 Dec 1;39(12):2218-2223. Epub 2018 Nov 1.

Department of Neurology (J.G.), New York University School of Medicine, New York, New York.

Background And Purpose: Normal Pressure Hydrocephalus is a reversible form of dementia characterized by enlarged ventricles, which can deform and cause disruptions to adjacent white matter fibers. The purpose of this work was to examine how diffusion and kurtosis parameters vary along the corticospinal tract and determine where along this path microstructure is compromised in patients diagnosed with normal pressure hydrocephalus. We hypothesized that disruption of the corticospinal tract from ventricular enlargement can be measured using diffusion MR imaging and this will be quantified in periventricular regions. Read More

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http://dx.doi.org/10.3174/ajnr.A5845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295239PMC
December 2018
2 Reads

The glymphatic pathway in neurological disorders.

Lancet Neurol 2018 Nov;17(11):1016-1024

Centre for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:

Background: The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along arterial perivascular spaces and subsequently into the brain interstitium, facilitated by aquaporin 4 (AQP4) water channels. The pathway then directs flow towards the venous perivascular and perineuronal spaces, ultimately clearing solutes from the neuropil into meningeal and cervical lymphatic drainage vessels. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14744422183031
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http://dx.doi.org/10.1016/S1474-4422(18)30318-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261373PMC
November 2018
10 Reads

Letter to the Editor Regarding "The Quest for Predicting Sustained Shunt Response in Normal-Pressure Hydrocephalus: An Analysis of the Callosal Angle's Utility".

World Neurosurg 2018 11;119:452

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2018.07.128DOI Listing
November 2018

Idiopathic normal-pressure hydrocephalus and obstructive sleep apnea are frequently associated: A prospective cohort study.

J Neurol Sci 2018 Dec 3;395:164-168. Epub 2018 Oct 3.

Department of Radiology MRI Core, Houston Methodist Hospital and Methodist Research Institute for Academic Medicine, Houston, TX, USA; Department of Radiology, Weill Cornell Medical College, Cornell University, New York, NY, USA.

Background: Idiopathic normal-pressure hydrocephalus (iNPH) is defined by ventriculomegaly, cognitive decline, urinary incontinence and gait problems. Vascular risk factors (VRF) are associated with iNPH but obstructive sleep apnea (OSA) -a well-known independent VRF- is seldom mentioned.

Methods: We investigated the presence of sleep-disordered breathing in a prospective cohort of 31 consecutive unselected patients with iNPH using sleep questionnaires and nocturnal polysomnography (PSG). Read More

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http://dx.doi.org/10.1016/j.jns.2018.10.005DOI Listing
December 2018
1 Read

Efficacy and safety of programmable compared with fixed anti-siphon devices for treating idiopathic normal-pressure hydrocephalus (iNPH) in adults - SYGRAVA: study protocol for a randomized trial.

Trials 2018 Oct 17;19(1):566. Epub 2018 Oct 17.

Centre for Clinical Research, Unfallkrankenhaus Berlin, Warener Str. 7, 12683, Berlin, Germany.

Background: Idiopathic normal-pressure hydrocephalus (iNPH) is a distinct form of dementia, characterized by gait ataxia, cognitive impairment and urinary incontinence. In contrast to all other causes of dementia (e.g. Read More

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http://dx.doi.org/10.1186/s13063-018-2951-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192316PMC
October 2018

Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus.

Glia 2018 Oct 10. Epub 2018 Oct 10.

Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway.

Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of dementia that may be successfully treated with cerebrospinal fluid (CSF) diversion. Recently, magnetic resonance imaging (MRI) using a MRI contrast agent as a CSF tracer revealed impaired clearance of the CSF tracer from various brain regions such as the entorhinal cortex of iNPH patients. Hampered clearance of waste solutes, for example, soluble amyloid-β, may underlie neurodegeneration and dementia in iNPH. Read More

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http://doi.wiley.com/10.1002/glia.23528
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http://dx.doi.org/10.1002/glia.23528DOI Listing
October 2018
3 Reads

Parkinsonian Patient with Comorbid Normal Pressure Hydrocephalus : Clinical Usefulness of Diagnosis Supported by Neurological Findings.

Clin Neuroradiol 2018 Dec 8;28(4):617-618. Epub 2018 Oct 8.

Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, Seoul, Korea (Republic of).

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http://link.springer.com/10.1007/s00062-018-0730-0
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http://dx.doi.org/10.1007/s00062-018-0730-0DOI Listing
December 2018
5 Reads

Hemangioblastomatosis-associated negative-pressure hydrocephalus managed with improvised shunt.

J Clin Neurosci 2018 Dec 1;58:226-228. Epub 2018 Oct 1.

National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. Electronic address:

Low-pressure hydrocephalus (LPH) is a rare clinical diagnosis, characterized by neurologic decline and ventriculomegaly that persists despite normal to low intracranial pressure. LPH is typically managed by negative-pressure drainage via ventriculostomy, followed by low-resistance shunt insertion. We present the case of a middle-aged man with a history of hemangioblastomatosis who had spontaneous subarachnoid hemorrhage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183059
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http://dx.doi.org/10.1016/j.jocn.2018.08.028DOI Listing
December 2018
6 Reads

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients.

Acta Neuropathol Commun 2018 Oct 1;6(1):102. Epub 2018 Oct 1.

Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum 5th floor, SE-141 57, Huddinge, Sweden.

Idiopathic normal pressure hydrocephalus (iNPH) is a neuropathology with unknown cause characterised by gait impairment, cognitive decline and ventriculomegaly. These patients often present comorbidity with Alzheimer's disease (AD), including AD pathological hallmarks such as amyloid plaques mainly consisting of amyloid β-peptide and neurofibrillary tangles consisting of hyperphosphorylated tau protein. Even though some of the molecular mechanisms behind AD are well described, little is known about iNPH. Read More

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http://dx.doi.org/10.1186/s40478-018-0605-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166280PMC
October 2018
4 Reads

Regional dissociation between the cerebral blood flow and gray matter density alterations in idiopathic normal pressure hydrocephalous: results from SINPHONI-2 study.

Neuroradiology 2018 Sep 30. Epub 2018 Sep 30.

Department of Neurosurgery, Tama-Hokubu Medical Center, Health and Medical Treatment Corporation, Higashimurayamashi, Tokyo, Japan.

Purpose: The purpose of this study was to elucidate the specific regional cerebral blood flow (rCBF) alterations for idiopathic normal pressure hydrocephalus (iNPH) by comparing the proportional rCBF and gray matter change from those of a normal database at the same point of SPECT and MRI examinations.

Methods: Thirty subjects with iNPH underwent both CBF SPECT and MRI. After normalization, voxel-wise two-sample t tests between patients and 11 normal controls were conducted to compare the regional alteration in the gray matter density and rCBF. Read More

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http://dx.doi.org/10.1007/s00234-018-2106-1DOI Listing
September 2018

Telemetry in intracranial pressure monitoring: sensor survival and drift.

Acta Neurochir (Wien) 2018 Nov 29;160(11):2137-2144. Epub 2018 Sep 29.

Clinic of Neurosurgery, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Background: Telemetric intracranial pressure (ICP) monitoring enable long-term ICP monitoring on patients during normal day activities and may accordingly be of use during evaluation and treatment of complicated ICP disorders. However, the benefits of such equipment depend strongly on the validity of the recordings and how often the telemetric sensor needs to be re-implanted. This study investigates the clinical and technical sensor survival time and drift of the telemetric ICP sensor: Raumedic Neurovent-P-tel. Read More

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http://link.springer.com/10.1007/s00701-018-3691-9
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http://dx.doi.org/10.1007/s00701-018-3691-9DOI Listing
November 2018
4 Reads

Improved lumbar infusion test analysis for normal pressure hydrocephalus diagnosis.

Brain Behav 2018 Nov 27;8(11):e01125. Epub 2018 Sep 27.

Department of Neurosurgery, Skane University Hospital, Lund, Sweden.

Objectives: Constant infusion lumbar infusion test (LIT) is an important way to find which patients, of those with signs and symptoms corresponding to normal pressure hydrocephalus (NPH) who will improve from shunt operation. LIT is a stress test on the ability for cerebrospinal fluid re-absorbtion. The aim of this study is to show how the information from LIT can be improved by quantitative analysis and avoidance of methodological pitfalls. Read More

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http://doi.wiley.com/10.1002/brb3.1125
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http://dx.doi.org/10.1002/brb3.1125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236248PMC
November 2018
12 Reads

Preoperative Phosphorylated Tau Concentration in the Cerebrospinal Fluid Can Predict Cognitive Function Three Years after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus.

J Alzheimers Dis 2018 ;66(1):319-331

Department of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.

Background: Idiopathic normal pressure hydrocephalus (iNPH) is commonly treated by cerebrospinal fluid (CSF) shunting. However, the long-term efficacy of shunt intervention in the presence of comorbid Alzheimer's disease (AD) pathology is debated.

Objective: To identify AD-associated CSF biomarkers predictive of shunting surgery outcomes in patients with iNPH. Read More

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http://dx.doi.org/10.3233/JAD-180557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218133PMC
January 2018
1 Read

Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus.

Neuroimage Clin 2018 14;20:731-741. Epub 2018 Sep 14.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway. Electronic address:

The aim of the present study was to examine cerebrospinal fluid (CSF) volumetric net flow rate and direction at the cranio-cervical junction (CCJ) and cerebral aqueduct in individuals with idiopathic normal pressure hydrocephalus (iNPH) using cardiac-gated phase-contrast magnetic resonance imaging (PC-MRI). An in-depth, pixel-by-pixel analysis of regions of interest from the CCJ and cerebral aqueduct, respectively, was done in 26 iNPH individuals, and in 4 healthy subjects for validation purposes. Results from patients were compared with over-night measurements of static and pulsatile intracranial pressure (ICP). Read More

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http://dx.doi.org/10.1016/j.nicl.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154456PMC
September 2018
1 Read

Change in average peak cerebrospinal fluid velocity at the cerebral aqueduct, before and after lumbar CSF tapping by the use of phase contrast MRI, and its effect on gait improvement in patients with normal pressure hydrocephalus.

Neurol India 2018 Sep-Oct;66(5):1407-1412

Department of Radiology and Imaging Sciences, Malabar Institute of Medical Sciences, Calicut, Kerala, India.

Objectives: To compare the change in peak cerebrospinal (CSF) flow velocity at the cerebral aqueduct in patients with normal pressure hydrocephalus (NPH) before and after CSF tapping with clinical outcome of the patients, i.e., gait improvement. Read More

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http://dx.doi.org/10.4103/0028-3886.241406DOI Listing
September 2018
2 Reads

Cognitive and upper limb symptom changes from a tap test in Idiopathic Normal Pressure Hydrocephalus.

Clin Neurol Neurosurg 2018 Nov 10;174:92-96. Epub 2018 Sep 10.

School of Health Sciences, The University of Newcastle, Newcastle, Australia.

Objectives: To determine which cognitive and upper limb assessments can identify change in patients undergoing a Cerebrospinal fluid (CSF) tap test (TT) diagnosed with idiopathic Normal Pressure Hydrocephalus (iNPH).

Patients And Methods: Prospective observational study of 74 iNPH patients undergoing a CSF TT for consideration of a ventricular peritoneal shunt. Patients who were offered surgical intervention were classified as responders. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.09.015DOI Listing
November 2018

Predictors of distal malfunction after ventriculoperitoneal shunting for idiopathic normal pressure hydrocephalus and effect of general surgery involvement.

Clin Neurol Neurosurg 2018 Nov 5;174:75-79. Epub 2018 Sep 5.

Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA; Department of Bioengineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedics, Mayo Clinic, Rochester, MN, USA. Electronic address:

Objectives: Distal obstruction is a common cause of shunt failure and need for revision in patients undergoing ventriculoperitoneal shunting (VPS) for idiopathic normal pressure hydrocephalus (iNPH).

Patients And Methods: Records of patients with iNPH treated with VPS between 2001 and 2017 were reviewed. Patients undergoing initial shunt placement at our institution were included for analysis and the incidence of revision surgery due to distal obstruction was noted. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.09.009DOI Listing
November 2018

Ventricular Volume Dynamics During the Development of Adult Chronic Communicating Hydrocephalus in a Rodent Model.

World Neurosurg 2018 Dec 11;120:e1120-e1127. Epub 2018 Sep 11.

Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA; Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia. Electronic address:

Introduction: The pathophysiology of normal-pressure hydrocephalus and the correlation with its symptomatology is not well understood.

Objective: To monitor and evaluate the enlargement patterns of the ventricular system for each ventricle and its correlation with the presenting symptoms.

Methods: Bilateral kaolin injection into the subarachnoid space overlying the cranial convexities was done in 18 adult rats. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.241DOI Listing
December 2018
1 Read
2.420 Impact Factor

Particular CSF sphingolipid patterns identify iNPH and AD patients.

Sci Rep 2018 Sep 11;8(1):13639. Epub 2018 Sep 11.

Department of Biomedical Sciences for Health, University of Milan, Segrate (Milan), Italy.

Idiopathic normal pressure hydrocephalus (iNPH) is characterized by reversible neurological symptoms due to an impairment in cerebrospinal fluid (CSF) clearance. In these patients, cognitive functions are severely impaired, with a scenario similar to Alzheimer's disease (AD), making the differential diagnosis difficult and highlighting the need of new markers. We analyzed the composition of sphingolipids (SLs) in serum, by combining a single phase extraction with a high-performance thin-layer chromatography (HPTLC) primuline-profiling, and, in CSF, by MALDI profiling and LC-MS. Read More

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http://www.nature.com/articles/s41598-018-31756-0
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http://dx.doi.org/10.1038/s41598-018-31756-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133966PMC
September 2018
5 Reads

Lateral Ventricle Enlargement and Cortical Thinning in Idiopathic Normal-pressure Hydrocephalus Patients.

Sci Rep 2018 Sep 6;8(1):13306. Epub 2018 Sep 6.

Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.

We utilized three-dimensional, surface-based, morphometric analysis to investigate ventricle shape between 2 groups: (1) idiopathic normal-pressure hydrocephalus (INPH) patients who had a positive response to the cerebrospinal fluid tap test (CSFTT) and (2) healthy controls. The aims were (1) to evaluate the location of INPH-related structural abnormalities of the lateral ventricles and (2) to investigate relationships between lateral ventricular enlargement and cortical thinning in INPH patients. Thirty-three INPH patients and 23 healthy controls were included in this study. Read More

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http://dx.doi.org/10.1038/s41598-018-31399-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127145PMC
September 2018
12 Reads

Commentary: Utility of Preoperative Simulation for Ventricular Catheter Placement via a Parietooccipital Approach in Normal-Pressure Hydrocephalus.

Oper Neurosurg (Hagerstown) 2018 Sep 4. Epub 2018 Sep 4.

Department of Neurosurgery, National Neuroscience Institute, and Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1093/ons/opy226DOI Listing
September 2018

Utility of Preoperative Simulation for Ventricular Catheter Placement via a Parieto-Occipital Approach in Normal-Pressure Hydrocephalus.

Oper Neurosurg (Hagerstown) 2018 Aug 30. Epub 2018 Aug 30.

Department of Neurosurgery and Stroke Center, Rakuwakai Otowa Hospital, Kyoto, Japan.

Background: Freehand ventricular catheter placement has been reported to have poor accuracy.

Objective: To investigate whether preoperative computational simulation using diagnostic images improves the accuracy of ventricular catheter placement.

Methods: This study included 113 consecutive patients with normal-pressure hydrocephalus (NPH), who underwent ventriculoperitoneal shunting via a parieto-occipital approach. Read More

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http://dx.doi.org/10.1093/ons/opy193DOI Listing

Ventriculoperitoneal Shunt Complications in the European Idiopathic Normal Pressure Hydrocephalus Multicenter Study.

Oper Neurosurg (Hagerstown) 2018 Aug 30. Epub 2018 Aug 30.

Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Ventriculoperitoneal shunt (VP-shunt) is the standard of treatment for idiopathic normal pressure hydrocephalus (iNPH). However, a thorough investigation of VP-shunt complications in this population is lacking.

Objective: To present the analysis and the rates of complications progressively occurring during the first year after shunt surgery in the patients with iNPH included in the European multicenter (EU-iNPH) study. Read More

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http://dx.doi.org/10.1093/ons/opy232DOI Listing
August 2018
1 Read

Wall-eyed Bilateral Internuclear Ophthalmoplegia (WEBINO) in a Patient With Idiopathic Intracranial Hypertension.

Neurologist 2018 Sep;23(5):157-159

Neurology, AZ Maria Middelares.

Introduction: Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) is a variant syndrome of internuclear ophthalmoplegia, consisting of primary gaze exotropia, adduction impairment, nystagmus of the abducting eye, and vertical gaze-evoked nystagmus. It seems to be most frequently associated with multiple sclerosis, although other etiologies such as brainstem ischemia or hydrocephalus have also been described.

Case Report: We report the case of a 25-year-old woman who presented with subacute progressive oculomotor disturbances, resulting in the development of a WEBINO over a few days. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000192DOI Listing
September 2018
15 Reads

Dopaminergic imaging separates normal pressure hydrocephalus from its mimics.

J Neurol 2018 Oct 28;265(10):2434-2441. Epub 2018 Aug 28.

Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Objective: Idiopathic normal pressure hydrocephalus (iNPH) and iNPH mimics (i.e., Parkinson's disease, progressive supranuclear palsy or dementia with Lewy bodies) share similar clinical features, and discrimination between both conditions relies on invasive time-consuming investigations. Read More

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http://dx.doi.org/10.1007/s00415-018-9029-yDOI Listing
October 2018
6 Reads

Delayed symptom progression after ventriculoperitoneal shunt placement for normal pressure hydrocephalus.

J Neurol Sci 2018 Oct 6;393:105-109. Epub 2018 Aug 6.

Department of Neurological Surgery, University of Miami Miller School of Medicine, 1095 NW 14(th) Terrace (D4-6), Miami, FL 33136, United States.

Normal pressure hydrocephalus (NPH) is generally treated with ventriculoperitoneal shunts (VPS), with improved symptoms in the majority of patients. We performed a retrospective chart review study in order to describe patterns of, and risk factors for, delayed symptom progression after initially successful VPS placement. 69 consecutive patients underwent VPS placement for NPH, and were followed for a minimum of 12 months postoperatively. Read More

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http://dx.doi.org/10.1016/j.jns.2018.08.002DOI Listing
October 2018

Clinical Experience with Cerebrospinal Fluid Aβ42, Total and Phosphorylated Tau in the Evaluation of 1,016 Individuals for Suspected Dementia.

J Alzheimers Dis 2018 ;65(4):1417-1425

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Background: Elevated total tau (tTau), 181-phosphorylated phosphorylated tau (pTau), and low amyloid-β42 (Aβ42) in cerebrospinal fluid (CSF) represent a diagnostic biomarker for Alzheimer's disease (AD).

Objective: The goal was to determine the overall accuracy of CSF Aβ42, tTau, pTau, and the Aβ42/total tau index (ATI) in a non-research, clinical setting for the diagnosis of AD.

Methods: From medical records in 1,016 patients that had CSF studies for dementia over a 12-year period (2005 to 2017), we calculated the sensitivity and specificity of CSF Aβ42, tTau, and pTau and the ATI in relation to the final clinical diagnosis. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-180548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218126PMC
January 2018
2 Reads

[The surgical treatment in adults with idiopathic normal pressure hydrocephalus].

Zhonghua Yi Xue Za Zhi 2018 Aug;98(31):2485-2488

The Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To investigate the effect of Ventriculoperitoneal shunt (VPS)in adult patients with idiopathic normal pressure hydrocephalus (iNPH). The patients with idiopathic normal pressure hydrocephalus were reviewed, who were admitted into the Peking union medical college hospital from October 2010 to October 2016.The patients treated via VPS were retrospectively analyzed by collecting the data including clinic features, iNPH score and imaging data. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.31.007DOI Listing
August 2018
8 Reads