1,623,276 results match your criteria Normal Labor and Delivery


Myofascial Pain.

Semin Neurol 2018 Dec 6;38(6):640-643. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Myofascial pain syndromes arise from acute and chronic musculoskeletal pain and often have a referred neuropathic component. It affects more than three quarters of the world's population and is one of the most important and overlooked causes of disability. The origins of pain are thought to reside anywhere between the motor end plate and the fibrous outer covering of the muscle, with involvement of microvasculature and neurotransmitters at the cellular level. Read More

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December 2018
4 Reads

Neurofilament Light in the Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium.

Dement Geriatr Cogn Disord 2018 Dec 6;46(5-6):346-357. Epub 2018 Dec 6.

Oslo Delirium Research Group, Department of Geriatric Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury.

Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Read More

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December 2018
2 Reads

Impact of Hybrid Therapy Comprising Peritoneal Dialysis and Hemodialysis on Acute Cardiovascular Events.

Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.

Background: The impact of hybrid therapy comprising peritoneal dialysis (PD) and hemodialysis on cardiovascular events in PD patients remains unclear.

Objective: We aimed to evaluate the effect of hybrid therapy on cardiovascular events.

Methods: A total of 93 PD patients undergoing hybrid therapy for ≥3 years were divided into 2 groups according to left ventricular ejection fraction (LVEF): lower ejection fraction (LEF [n = 29], LVEF < 60%) and normal ejection fraction (NEF [n = 64], LVEF ≥60%). Read More

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December 2018
2 Reads

miR-122 Targets X-Linked Inhibitor of Apoptosis Protein to Sensitize Oxaliplatin-Resistant Colorectal Cancer Cells to Oxaliplatin-Mediated Cytotoxicity.

Cell Physiol Biochem 2018 Dec 6;51(5):2148-2159. Epub 2018 Dec 6.

Minimally Invasive Treatment Center, Fudan University Shanghai Cancer Center, Shanghai,

Background/aims: Although oxaliplatin is one of the most effective chemotherapeutic drugs used to treat colorectal cancer (CRC), long-term administration usually induces acquired drug resistance during the course of treatment. Thus, there is an urgent need to explore novel strategies to improve the efficiency of cancer therapy. The aim of this study was to explore the effect of microRNA-122 (miR-122) on reversing oxaliplatin resistance in CRC. Read More

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December 2018
2 Reads

Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway.

Cell Physiol Biochem 2018 Dec 6;51(5):2030-2040. Epub 2018 Dec 6.

Department of Obstetrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing,

Background/aims: Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion.

Methods: LN-α5 expression levels were examined by reverse-transcriptase polymerase chain reaction (RT-PCR), and further confirmed by western blotting and immunofluorescence staining. Read More

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December 2018
1 Read

Management of slurry in Gran Canaria Island with full-scale natural treatment systems for wastewater (NTSW). One year experience in livestock farms.

J Environ Manage 2018 Dec 3;232:666-678. Epub 2018 Dec 3.

Institute for Environmental Studies and Natural Resources (i-UNAT), University of Las Palmas de Gran Canaria, Spain. Electronic address:

The aim of this work is to describe the performance of three full-scale natural treatment systems for wastewater, which operated in an integrated manner in livestock pig farms (1000-1500pigsintotal) over one year. Slurry management was performed with these natural treatment systems operating under the normal waste loading conditions of the livestock farms in which were integrated. The systems were comprised of elements such as first generation digesters, subsurface flow constructed wetlands and facultative ponds. Read More

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December 2018
1 Read

Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2018 Dec 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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December 2018
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Discovery and development of small molecule modulators targeting glutamine metabolism.

Eur J Med Chem 2018 Nov 28;163:215-242. Epub 2018 Nov 28.

Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address:

Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent on the glycolysis pathway and other atypical metabolic characteristics such as increased fatty acid synthesis and increased rates of glutamine metabolism. Among these metabolic features of cancers, glutamine metabolism has been reported to be the main energy supply for the growth and viability of a potentially large subset of malignant tumors. Read More

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November 2018
5 Reads

A simple yet sensitive colorimetric nitrite ions assay based on diazotization with p‑Aminobenzoic and coupling with phloroglucinol in acidic medium.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Aug 25;210:398-404. Epub 2018 Aug 25.

Key Laboratory of Bioelectrochemistry & Analysis of Gansu Province, College of Chemistry& Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China. Electronic address:

Immoderate intake of nitrite (NO) is deleterious human health and may result in causing dangerous diseases. In this study, nitrite detection system was successfully fabricated based on a unique diazo-coupling reaction of p‑Aminobenzoic acid (PABA) and phloroglucinol (1, 3, 5‑trihydroxybenzene). Upon the presence of NO in an acid medium, p‑Aminobenzoic acid could not only form diazonium ion easily but also couple with p‑Aminobenzoic acid, and results forming yellow water-soluble azo dye that shows maximum absorption at 434 nm. Read More

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August 2018
1 Read

Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies.

Environ Int 2018 Dec 3;123:124-131. Epub 2018 Dec 3.

MRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute for Genomic Medicine (IIGM), Turin, Italy. Electronic address:

Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were allocated to high or low air pollution exposures. The two locations represent different exposure scenarios, with Oxford Street characterized by diesel vehicles and Barcelona by normal mixed urban traffic. Read More

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December 2018
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Engineering of pectin-dopamine nano-conjugates for carrying ruthenium complex: A potential tool for biomedical applications.

J Inorg Biochem 2018 Nov 28;191:135-142. Epub 2018 Nov 28.

Institute of Environmental Toxicology and Environmental Ecology, Yancheng Teachers University, Yancheng City, Jiangsu Province 224007, People's Republic of China. Electronic address:

In this work, we designed polysaccharide-metal complex of dopamine-modified pectin linking ruthenium compound, which exhibited a certain inhibition specificity to human renal cell adenocarcinoma cell line 786-O. The chemical structure and physical properties of the polysaccharide-metal complex were well characterized by multiple analysis methods. The multi-spectral results revealed that pectin-dopamine have been successfully coordinated by ruthenium complex to form nano-conjugates, which self-assembled into relatively regular nanospheres of approximately 200 nm. Read More

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November 2018
4 Reads

Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Lipid homeostasis is important for executing normal cellular functions and maintaining physiological conditions. The biophysical properties and intricate metabolic network of lipids underlie the coordinated regulation of different lipid species in lipid homeostasis. To reveal the homeostatic response among different lipids, we systematically knocked down 40 lipid metabolism genes in Drosophila S2 cells by RNAi and profiled the lipidomic changes. Read More

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December 2018

Chitosan-graft-poly(N-hydroxy ethyl acrylamide) copolymers: Synthesis, characterization and preliminary blood compatibility in vitro.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biomedical Engineering, Near East University, Nicosia, P. O. Box: 99138, North Cyprus via Mersin 10, Turkey; Tissue Engineering and Biomaterials Research Centre, Near East University, P. O. Box: 99138, North Cyprus via Mersin 10, Turkey.

Poly(N-hydroxy ethyl acrylamide) was grafted onto chitosan in aqueous acidic medium using potassium per sulphate initiator to obtain polymer surfaces with blood compatibility for potential biomedical applications. Thermally cross-linked products were obtained upon drying at 60 °C overnight. Chemically cross-linked films were prepared using methylene bis acrylamide (MBA) cross-linker. Read More

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December 2018

Physicochemical responses and microbiological changes of bream (Megalobrama ambycephala) to pectin based coatings enriched with clove essential oil during refrigeration.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, PR China. Electronic address:

The effectiveness of pectin coatings enriched with clove essential oil (CEO), as new edible coatings were investigated to preserve bream (Megalobrama ambycephala) fillets during refrigeration over a period of 15 days. All samples were analyzed for physicochemical (pH, PV, TBA and TVB-N), microbiological (Total viable count, Psychrophilic bacteria, Lactic acid bacteria, Enterobacteriaceae, Pseudomonas spp., HS producing bacteria) and organoleptic attributes. Read More

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December 2018

Anticancer activity modulation of an innovative solid formulation of extra virgin olive oil by cultured zeolite scaffolds.

Food Chem Toxicol 2018 Dec 3. Epub 2018 Dec 3.

Research Institute on Membrane Technology, Unit of Zeolite Membranes, ITM-CNR, University of Calabria, Cubo 17/c, 87036, Rende, Italy.

This paper deals with the design and manufacture of pure and hybrid synthetic (Mixed Matrix Membranes, MMMs) zeolite scaffolds (containing various amount of zeolite crystals dispersed in a polymeric matrix) to obtain new biomaterials. These scaffolds can potentially be used in the field of translational medicine to obtain innovative results to address tumorigenesis mechanisms with the promotion of an effort to deal with technical methods and information. Since olive oil has beneficial effects in healthy human cells and slows down and/or inhibits cell growth, the aim of this work was to monitor the protective and beneficial antitumor effects of olive oil in a new solid formulation (Spread Bio-Oil) on cancer cell cultured on zeolite scaffolds. Read More

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December 2018

Renoprotective meroterpenoids from the fungus Ganoderma cochlear.

Fitoterapia 2018 Dec 3. Epub 2018 Dec 3.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China. Electronic address:

Nine multifarious new meroterpenoids, cochlearols E-M (1-9), along with seven known meroterpenoids 10-16, were isolated from the fruiting bodies of Ganoderma cochlear. Racemic 1, 6-8, 10 and 13 were separated by chiral HPLC. The structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and calculated electronic circular dichroism (ECD). Read More

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December 2018

Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols.

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas.

Background: Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus. We demonstrated previously that offspring born to pregnant mice lacking endothelial nitric oxide synthase (eNOS+/-) gene have hypertension (HTN) as adults and when fed high fat diet (HFD) develop a metabolic syndrome (MS) phenotype.

Objective: Our aim was to evaluate if INOs treatment in pregnancy complicated by MS improves the vascular and metabolic profile in mice offspring programmed in utero to develop HTN and MS. Read More

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December 2018

Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration.

Neuron 2018 Dec;100(5):1241-1251.e7

Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland; Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

Large numbers of brain regions are active during behaviors. A high-resolution, brain-wide activity map could identify brain regions involved in specific behaviors. We have developed functional ultrasound imaging to record whole-brain activity in behaving mice at a resolution of ∼100 μm. Read More

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December 2018
1 Read

[Postoperative functional angular anatomy in patients with anterior cruciate ligament with autologous graft].

Acta Ortop Mex 2018 May-Jun;32(3):157-162

Servicio de Cirugía Articular, Hospital Juárez de México, Ciudad de México.

Background: Reconstruction of the anterior cruciate ligament (ACL) aims to restore the original anatomy. The clinical outcome could be imperfect when graft placement is not in an anatomical position; moreover, the conventional transtibial reconstruction of the ACL often locates the graft away from the anatomical site, leading to abnormal biomechanical behavior and kinematics of the knee. The objective of this work was to assess the importance of the angular reconstruction of the anterior cruciate ligament during arthroscopic replacement and to compare the postoperative functional results. Read More

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December 2018

[Prevalence of osteoporosis and osteopenia in patients occupationally active].

Acta Ortop Mex 2018 May-Jun;32(3):131-133

Clínica de Detección y Diagnóstico Automatizado, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Ciudad de México.

Background: Osteoporosis is a public health problem worldwide, affecting more than 200 million people. It is estimated that 30 to 50% of postmenopausal women suffer from it. According to the International Osteoporosis Foundation (IOF), osteoporosis is a disease characterized by a decrease in the density and quality of bones. Read More

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December 2018

Teledermatology for diagnosing skin cancer in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013193. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More

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December 2018
5 Reads

Binocular Summation for Reflexive Eye Movements: A Potential Diagnostic Tool for Stereodeficiencies.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5816-5822

Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, United States.

Purpose: Stereoscopic vision, by detecting interocular correlations, enhances depth perception. Stereodeficiencies often emerge during the first months of life, and left untreated can lead to severe loss of visual acuity in one eye and/or strabismus. Early treatment results in much better outcomes, yet diagnostic tests for infants are cumbersome and not widely available. Read More

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December 2018

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5803-5815

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To determine if drug-induced peroxisome proliferator-activated receptor α (PPARα) signal pathway modulation affects refractive development and myopia in guinea pigs.

Methods: Pigmented guinea pigs were randomly divided into normal vision (unoccluded) and form deprivation myopia (FDM) groups. Each group received daily peribulbar injections of either a vehicle or (1) PPARα agonist, GW7647, clofibrate, or bezafibrate or (2) PPARα antagonist, GW6471, for 4 weeks. Read More

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December 2018

Diagnosing the double burden of malnutrition using estimated deviation values in low- and lower-middle-income countries.

PLoS One 2018 6;13(12):e0208525. Epub 2018 Dec 6.

Department of International Health and Collaboration, National Institute of Public Health, Saitama, Japan.

Objective: To examine the possibility of diagnosing the double burden of malnutrition using estimated deviation values in low- and lower-middle-income countries.

Methods: A modified version of the Japanese Diagnostic Tool was used. Data on 194 countries were analyzed, including data from the United Nations International Children's Fund, World Health Organization and World Bank. Read More

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December 2018
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Transmission dynamics of re-emerging rabies in domestic dogs of rural China.

PLoS Pathog 2018 Dec 6;14(12):e1007392. Epub 2018 Dec 6.

KU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Evolutionary and Computational Virology, Leuven, Belgium.

Despite ongoing efforts to control transmission, rabies prevention remains a challenge in many developing countries, especially in rural areas of China where re-emerging rabies is under-reported due to a lack of sustained animal surveillance. By taking advantage of detailed genomic and epidemiological data for the re-emerging rabies outbreak in Yunnan Province, China, collected between 1999 and 2015, we reconstruct the demographic and dispersal history of domestic dog rabies virus (RABV) as well as the dynamics of dog-to-dog and dog-to-human transmission. Phylogeographic analyses reveal a lower diffusion coefficient than previously estimated for dog RABV dissemination in northern Africa. Read More

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December 2018

Does perceived ostracism contribute to mental health concerns among veterans who have been deployed?

PLoS One 2018 6;13(12):e0208438. Epub 2018 Dec 6.

Department of Psychology, Illinois State University, Normal, Illinois, United States of America.

Posttraumatic stress-negative psychological experiences as a result of traumatic stressors-can hinder military veterans' reintegration into society and cause various mental health problems. Veterans need quality social relationships to facilitate reintegration and to cope with posttraumatic stress and related mental health problems; discrimination or other forms of interpersonal rejection can exacerbate these veterans' problems. Ostracism (i. Read More

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December 2018

The effect of water-based plyometric training on vertical stiffness and athletic performance.

PLoS One 2018 6;13(12):e0208439. Epub 2018 Dec 6.

Human Performance Research Centre, Faculty of Health, University of Technology Sydney, Australia.

Since higher vertical stiffness is related to superior athletic performance, training has traditionally been aimed at augmenting this variable to enhance neuromuscular output. However, research has linked elevated stiffness with increased injury risk, therefore, this study examined the effect of a novel training intervention on vertical stiffness and athletic performance. Vertical stiffness, jump performance and athletic performance were assessed in two randomly allocated groups, prior to, and following, an eight-week period. Read More

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December 2018

Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease.

PLoS One 2018 6;13(12):e0207843. Epub 2018 Dec 6.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Aims: To investigate associations of glomerular hyperfiltration with other metabolic factors in a nationally representative dataset.

Methods: We analyzed cross-sectional data from 15,918 subjects with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2 and urine albumin creation ratio (ACR) <30 mg/g, who participated in the 5th and 6th Korea National Health and Nutrition Examination Surveys. Read More

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December 2018

Identification of uterine telocytes and their architecture in leiomyoma.

Folia Med Cracov 2018 ;58(3):89-102

Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland.

Introduction: Uterine leiomyoma is the most widespread benign tumor affecting women of childbearing age. ere are still gaps in the understanding of its pathogenesiss. Telocytes are unique cells described in greater than 50 different locations inside the human body. Read More

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January 2018
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Tissue Specificity in Trisomy 22 Mosaicism: A Tale of Caution for Interpretation of Chromosomal Microarray Results.

J Assoc Genet Technol 2018 ;44(4):137-140

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Objectives: While the complete form of trisomy 22 is seemingly incompatible with life, the mosaic form is a rare syndrome associated with developmental delays, intellectual disability, and dysmorphic features. Due in part to the difficulty of analyzing chromosomal mosaicism, many instances either go undiagnosed or have their diagnosis delayed. We report a case of mosaic trisomy 22 in a diamnionic-dichorionic twin with marked growth discordance and intra-uterine growth restriction, diagnosed in a 2-year-old with developmental delays, sensorineural hearing loss, cardiac and gastrointestinal abnormalities, and osteopenia of prematurity. Read More

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January 2018
6 Reads

Not performing an OGTT results in underdiagnosis, inadequate risk assessment and probable cost increases of (pre)diabetes in Han Chinese over 40 years: a population based prospective cohort study.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

L Chen, Endocrinology, Tongji Hospital affiliated with Tongji Medical School of Huazhong University of Science and Technology, Wuhan, 430022, China.

Screening for (pre)diabetes is recommended in China using fasting blood glucose as routine strategy currently but not oral glucose tolerance test (OGTT) in high-risk population. We aimed to explore the impact by not performing an OGTT in Han Chinese over 40 years. 6682 participants were included in the prospective cohort study followed up for 3 years. Read More

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December 2018
2 Reads

ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling.

Endocr Connect 2018 Dec;7(12):1397-1408

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.

We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, in the outgrowth of urothelial cancer. In both neoplastic and non-neoplastic urothelial cells, the expression levels of androgen receptor (AR) correlated with those of phospho-ATF2. Dihydrotestosterone treatment in AR-positive bladder cancer cells also induced the expression of phospho-ATF2 and phospho-ERK as well as nuclear translocation and transcriptional activity of ATF2. Read More

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December 2018

Laparoscopic sleeve gastrectomy and gastroesophageal reflux.

Rom J Intern Med 2018 Dec;56(4):227-232

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

The prevalence of obesity is rising, becoming a medical problem worldwide. Also GERD incidence is higher in obese patients compared with normal weight, with an increased risk of 2.5 of developing symptoms and erosive esophagitis. Read More

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December 2018

The effect of net gas volume changes on alveolar and arterial gas partial pressures in the presence of ventilation-perfusion mismatch.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Department of Anaesthesia, Austin Hospital, Australia.

The second gas effect (SGE) occurs when nitrous oxide enhances the uptake of volatile anesthetics administered simultaneously. Recent work shows that the SGE is greater in blood than in the gas phase, that this is due to ventilation-perfusion mismatch, that as mismatch increases, the SGE increases in blood but is diminished in the gas phase, and that these effects persist well into the period of nitrous oxide maintenance anesthesia. These modifications of the SGE are most pronounced with the low soluble agents in current use. Read More

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December 2018

Ventilatory responses to acute hypoxia and hypercapnia in humans with a patent foramen ovale.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

School of Health and Exercise Science, University of British Columbia, Canada.

Subjects with a patent foramen ovale (PFO) have blunted ventilatory acclimatization to high altitude, compared to subjects without PFO. The blunted response observed could be due to differences in central and/or peripheral respiratory chemoreflexes. We hypothesized that compared to subjects without a PFO (PFO-), subjects with a PFO (PFO+) would have blunted ventilatory responses to acute hypoxia and hypercapnia. Read More

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December 2018

Residual Normality Assumption and the Estimation of Multiple Membership Random Effects Models.

Multivariate Behav Res 2018 Dec 6:1-16. Epub 2018 Dec 6.

a Department of Educational Policy Studies , Georgia State University.

While conventional hierarchical linear modeling is applicable to purely hierarchical data, a multiple membership random effects model (MMrem) is appropriate for nonpurely nested data wherein some lower-level units manifest mobility across higher-level units. Although a few recent studies have investigated the influence of cluster-level residual nonnormality on hierarchical linear modeling estimation for purely hierarchical data, no research has examined the statistical performance of an MMrem given residual non-normality. The purpose of the present study was to extend prior research on the influence of residual non-normality from purely nested data structures to multiple membership data structures. Read More

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December 2018
1 Read
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