6,106 results match your criteria Normal Labor and Delivery


One-step preparation of gold nanovectors using folate modified polyethylenimine and their use in target-specific gene transfection.

Colloids Surf B Biointerfaces 2019 Feb 6;177:306-312. Epub 2019 Feb 6.

State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.

Gene transfection, as an effective treatment for inherited and acquired life threatening diseases caused by genetic deficiencies and abnormalities, has evolved as a promising therapeutic strategy for cancer and other intractable diseases. Non-target-specific vectors will affect normal cells as well as pathogenic cells, resulting in a relative decrease in transfection efficiency and unnecessary cytotoxicity. In the present work, gold nanoparticles (AuNPs) functionalized with folate (FA)-modified polyethylenimine (PEI-FA) were prepared by a single step method (without additional reducing agent) for targeted gene transfection in tumor cells. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.011DOI Listing
February 2019

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect.

Acta Pharm Sin B 2019 Jan 20;9(1):74-86. Epub 2018 Sep 20.

Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China.

Diabetes mellitus (DM) remains a great challenge in treatment due to pathological complexity. It has been proven that phytomedicines and natural medicines have prominent antidiabetic effects. This work aimed to develop selenium-layered nanoparticles (SeNPs) for oral delivery of mulberry leaf and extracts (MPE), a group of phytomedicines with significant hypoglycemic activities, to achieve a synergic antidiabetic effect. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361850PMC
January 2019

Exercise intolerance in comorbid COPD-heart failure: the role of impaired aerobic function.

Eur Respir J 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Clinical Exercise Physiology and Respiratory Investigation Unit, Queen's University & Kingston General Hospital, Kingston, ON, Canada.

Impaired aerobic function is a potential mechanism of exercise intolerance in patients with combined cardiorespiratory disease. We investigated the pathophysiological and sensory consequences of a low Δ O uptake (V̇O)/Δ work rate (WR) relationship during incremental exercise in patients with coexisting chronic obstructive pulmonary disease (COPD) and systolic heart failure (HF).After clinical stabilisation, 51 COPD-HF patients performed an incremental cardiopulmonary exercise test to symptom limitation. Read More

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http://dx.doi.org/10.1183/13993003.02386-2018DOI Listing
February 2019

Factors that affect ultrasound-determined labor progress in women undergoing induction of labor.

Am J Obstet Gynecol 2019 Feb 5. Epub 2019 Feb 5.

Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR. Electronic address:

Background: The traditional approach to assessing labor progress is by digital vaginal examination, however, it is subjective and imprecise. Recent studies have investigated the role of transperineal ultrasonographic assessment of fetal head descent by measuring angle of progression and head-perineum distance.

Objective: The objective of this study was to evaluate factors that affected labor progress, defined by the transperineal ultrasonographic parameters, in women achieving vaginal delivery. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.236DOI Listing
February 2019
1 Read

Implications of vaginal instrumental delivery for children's school achievement: A population-based linked administrative data study.

Aust N Z J Obstet Gynaecol 2019 Feb 7. Epub 2019 Feb 7.

Department of Obstetrics and Gynaecology, Monash Medical Centre, Monash University, Melbourne, Victoria, Australia.

Background: Vaginal instrumental delivery is a common obstetrical intervention, but its effect on children's later development is not well known.

Aims: To determine if vaginal instrumental delivery is associated with adverse neurodevelopment as measured by school achievement.

Material And Methods: We performed a whole-of-population study involving linkage of routinely collected perinatal data with school assessments among children born in South Australia from 1999 to 2008. Read More

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http://dx.doi.org/10.1111/ajo.12952DOI Listing
February 2019
1 Read

Lipopolysaccharides inhibit REG3A self-aggregation on gold nanoparticles: A combined study of multivariate analysis on time-resolved local-surface-plasmon-resonance spectra and molecular modeling.

Langmuir 2019 Feb 6. Epub 2019 Feb 6.

Aggregation behavior of proteins on the surface of gold nanoparticles (AuNPs) has been extensively studied for its promising applications in biosensing, bioimaging, photodynamic therapy, drug delivery, etc. In this work, we studied adsorption kinetics of an antimicrobial protein, REG3A (regenerating islet-derived protein 3-alpha), on the surface of as-synthesized citrate-capped AuNPs under the influence of lipopolysaccharides (LPSs), with a combined method of UV-vis spectroscopy, multivariate analysis, and molecular dockings. In the AuNPs-REG3A binary system a component with the "up-and-down" signal was detected by the in-depth data analysis on the time-resolved spectroscopic data, corresponding with the protein agglomeration and exfoliation observed in the TEM (Transmission Electron Microscopy) and AFM (Atomic Force Microscopy) experiments. Read More

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http://dx.doi.org/10.1021/acs.langmuir.9b00087DOI Listing
February 2019
2 Reads

Entrapment of bacterial cellulose nanocrystals stabilized Pickering emulsions droplets in alginate beads for hydrophobic drug delivery.

Colloids Surf B Biointerfaces 2019 Jan 29;177:112-120. Epub 2019 Jan 29.

Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, China; Key Laboratory of Water Pollution Treatment & Resource Reuse of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, Hainan, China. Electronic address:

In this work, the interfacial assembly of amphiphilic bacterial cellulose nanocrystals (BCNs) by Pickering emulsion method was proposed to improve the compatibility between the alginate and hydrophobic drug. BCNs prepared by sulfuric acid hydrolysis of biosynthesized bacterial cellulose was used as the particulate emulsifiers, whereas the model drug, alfacalcidol, dissolved in CHCl was used as the oil phase. The oil-in-water Pickering emulsions were prepared by ultrasonic dispersion method and then they were well dispersed in alginate solution. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.057DOI Listing
January 2019
1 Read
4.152 Impact Factor

Toxic effects of magnetic nanoparticles on normal cells and organs.

Life Sci 2019 Mar 1;220:156-161. Epub 2019 Feb 1.

Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People's Republic of China. Electronic address:

Magnetic nanoparticles (MNPs) are promising candidates for drug delivery and treatment of various disorders. Toxicity evaluation is a critical point in the development of nanoformulations and therefore, draws considerable attention. Formulations involving individual or combinatorial nanoparticle suspensions might be used for targeted delivery and treatment. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.056DOI Listing

Oral immunization with recombinant Lactobacillus casei expressing flaB confers protection against Aeromonas veronii challenge in common carp, Cyprinus carpio.

Fish Shellfish Immunol 2019 Jan 30;87:627-637. Epub 2019 Jan 30.

College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China. Electronic address:

Aeromonas veronii is an important type of gram-negative pathogen of human-livestock-aquatic animal and causes great economic losses in the aquaculture industry. Vaccination is an effective method of defence against A. veronii. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.01.032DOI Listing
January 2019
1 Read

Pluronic F127-based micelles for tumor-targeted bufalin delivery.

Int J Pharm 2019 Jan 30;559:289-298. Epub 2019 Jan 30.

College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China. Electronic address:

In this study, we developed novel thermal and redox-responsive micelles based on the Pluronic F127 tri-block copolymer and employed these for redox-responsive intratumor release of bufalin, an anti-cancer drug. Pluronic F127 was first functionalized with carboxylate groups, and then assembled into micelles. The HOOC-F127-COOH micelles are 20 ± 4 nm in size at 37 °C, but expand to 281 ± 5 nm when cooled to 4 °C. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.049DOI Listing
January 2019

New windows into the brain: Central nervous system-derived extracellular vesicles in blood.

Prog Neurobiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA; Beijing Key Laboratory of Research and Transformation on Neurodegenerative Diseases Biomarkers, Department of Pathology, Peking University Third Hospital/Institute of Basic Science, Peking University Health Science Center, Beijing 100083, China. Electronic address:

Extracellular vesicles (EVs), including exosomes and (shedding) microvesicles, are released by nearly all cell types and carry a cargo of proteins and nucleic acids that varies by the cell of origin. They are thought to play critical roles in normal central nervous system (CNS) function and neurological disorders. A recently revealed key characteristic of EVs is that they may travel between the CNS and peripheral circulation. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.01.005DOI Listing
January 2019
2 Reads

Attenuation Coefficient Estimation of Normal Placentas.

Ultrasound Med Biol 2019 Jan 23. Epub 2019 Jan 23.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, British Columbia, Canada; Department of Mechanical Engineering, University of British Columbia, Vancouver, British Columbia, Canada.

Attenuation coefficient estimation has the potential to be a useful tool for placental tissue characterization. A current challenge is the presence of inhomogeneities in biological tissue that result in a large variance in the attenuation coefficient estimate (ACE), restricting its clinical utility. In this work, we propose a new Attenuation Estimation Region Of Interest (AEROI) selection method for computing the ACE based on the (i) envelope signal-to-noise ratio deviation and (ii) coefficient of variation of the transmit pulse bandwidth. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.10.015DOI Listing
January 2019
1 Read

Surface biofunctionalization of the decellularized porcine aortic valve with VEGF-loaded nanoparticles for accelerating endothelialization.

Mater Sci Eng C Mater Biol Appl 2019 Apr 26;97:632-643. Epub 2018 Dec 26.

Department of cardiovascular surgery, the Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

The original intention for building a tissue-engineered heart valve (TEHV) was to simulate a normal heart valve and overcome the insufficiency of the commonly used heart valve replacement in the clinic. The endothelialization of the TEHV is very important as the endothelialized TEHV can decrease platelet adhesion and delay the valvular calcification decline process. In this work, we encapsulated vascular endothelial growth factor (VEGF) into polycaprolactone (PCL) nanoparticles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183236
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http://dx.doi.org/10.1016/j.msec.2018.12.079DOI Listing
April 2019
3 Reads

The impact of birth anesthesia on the parameters of oxygenation and acid-base balance in umbilical cord blood.

J Matern Fetal Neonatal Med 2019 Feb 10:1-8. Epub 2019 Feb 10.

b Department of Gynecology and Obstetrics, Uniwersytet Warminsko-Mazurski Wydzial Nauk Medycznych , Olsztyn , Poland.

Background: There is a great number of studies dealing with the impact of birth anesthesia on the course of labor and condition of the newborn. The aim of this study was to investigate the impact of birth anesthesia on the parameters of oxygenation and acid-base balance in umbilical cord blood.

Methods: Subjects were divided into four groups: vaginal delivery without anesthesia, vaginal delivery with epidural anesthesia, delivery by cesarean section under a subarachnoid block, and delivery by cesarean section under general anesthesia. Read More

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http://dx.doi.org/10.1080/14767058.2019.1574740DOI Listing
February 2019
2 Reads

Effectiveness of a Novel Continuous Doppler (Moyo) Versus Intermittent Doppler in Intrapartum Detection of Abnormal Foetal Heart Rate: A Randomised Controlled Study in Tanzania.

Int J Environ Res Public Health 2019 Jan 24;16(3). Epub 2019 Jan 24.

Faculty of Health Sciences, University of Stavanger, 4036 Stavanger, Norway.

: Intrapartum foetal heart rate (FHR) monitoring is crucial for identification of hypoxic foetuses and subsequent interventions. We compared continuous monitoring using a novel nine-crystal FHR monitor (Moyo) versus intermittent single crystal Doppler (Doppler) for the detection of abnormal FHR. : An unmasked randomised controlled study was conducted in a tertiary hospital in Tanzania (ClinicalTrials. Read More

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http://dx.doi.org/10.3390/ijerph16030315DOI Listing
January 2019

Idarubicin-loaded methoxy poly(ethylene glycol)--poly(l-lactide-co-glycolide) nanoparticles for enhancing cellular uptake and promoting antileukemia activity.

Int J Nanomedicine 2019 11;14:543-556. Epub 2019 Jan 11.

Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang 325000, China,

Purpose: Nanoparticle (NP)-based drug delivery approaches have tremendous potential for enhancing treatment efficacy and decreasing doses of chemotherapeutics. Idarubicin (IDA) is one of the most common chemotherapeutic drugs used in the treatment of acute myeloid leukemia (AML). However, severe side effects and drug resistance markedly limit the application of IDA. Read More

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http://dx.doi.org/10.2147/IJN.S190027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333394PMC
January 2019
2 Reads

Platelet rich plasma hydrogels promote in vitro and in vivo angiogenic potential of adipose-derived stem cells.

Acta Biomater 2019 Jan 18. Epub 2019 Jan 18.

U.S. Army Institute of Surgical Research, Combat Trauma and Burn Injury Research, JBSA Fort Sam Houston, TX, USA. Electronic address:

Despite great advances in skin wound care utilizing grafting techniques, the resulting severe scarring, deformity and ineffective vascularization remains a challenge. Alternatively, tissue engineering of new skin using patient-derived stem cells and scaffolding materials promises to greatly increase the functional and aesthetic outcome of skin wound healing. This work focused on the optimization of a polyethylene glycol modified (PEGylated) platelet-rich plasma (PRP) hydrogel for the protracted release of cytokines, growth factors, and signaling molecules and also the delivery of a provisional physical framework for stem cell angiogenesis. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.039DOI Listing
January 2019
3 Reads

Timely initiation of breastfeeding among first time mothers in Bahir Dar city, North West, Ethiopia, 2016.

Pediatr Res 2019 Jan 19. Epub 2019 Jan 19.

Lecturer, Department of public health, Addis Ababa University College of Health Sciences School of Allied Health Sciences, Addis Ababa, Ethiopia.

Background: Timely initiation of breastfeeding is one important intervention to prevent childhood morbidities and mortalities. Globally, not more than 35 and 39% in developing countries, 52% in Ethiopia and 38% in Amhara region were initiated with breastfeeding early.

Methods: A community based cross-sectional study was conducted from 20 March to April, 2016. Read More

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http://dx.doi.org/10.1038/s41390-019-0299-6DOI Listing
January 2019
2 Reads

PEG-Detachable Polymeric Micelles Self-Assembled from Amphiphilic Copolymers for Tumor-Acidity-Triggered Drug Delivery and Controlled Release.

ACS Appl Mater Interfaces 2019 Feb 29;11(6):5701-5713. Epub 2019 Jan 29.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology of China, University of Chinese Academy of Sciences , Beijing 100190 , China.

The development of an intelligent biomaterial system that can efficiently accumulate at the tumor site and release a drug in a controlled way is very important for cancer chemotherapy. PEG is widely selected as a hydrophilic shell to acquire prolonged circulation time and enhanced accumulation at the tumor site, but it also restrains the cellular transport and uptake and leads to insufficient therapeutic efficacy. In this work, a PEG-detachable pH-responsive polymer that forms micelles from copolymer cholesterol grafted poly(ethylene glycol) methyl ether- D-poly(β-amino ester)- D-poly(ethylene glycol) methyl ether (MPEG- D-PAE- g-Chol) is developed to overcome the aforementioned challenges based on pH value changes among normal physiological, extracellular (pH), and intracellular (pH) environments. Read More

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http://dx.doi.org/10.1021/acsami.8b13059DOI Listing
February 2019
2 Reads

A comparative randomized study on effect of vaginally administered glyceryl trinitrate placebo on cervical ripening prior to induction of labor in overdue pregnancies.

Indian J Pharmacol 2018 Sep-Oct;50(5):260-265

Department of Nursing, Faculty of Health Science, Bandirma Onyedi Eylül University, Balikesir, Turkey.

Objective: The aim of this study is to examine the effectiveness and adverse effects of local glyceryl trinitrate (GTN) application during labor compared with a placebo group.

Methods: The study consisted of 70 pregnant women with overdue pregnancies who presented to the hospital for labor induction between January 2009 and January 2011 in the Obstetrics Clinic of Istanbul Süleymaniye Gynecology and Obstetrics Education and Training Hospital. Vaginal suppositories-containing GTN (36/70) or placebo (34/70) was administered to the participants in a randomized fashion. Read More

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http://dx.doi.org/10.4103/ijp.IJP_182_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302700PMC
January 2019
3 Reads

Association between fetal macrosomia and risk of obesity in children under 3 years in Western China: a cohort study.

World J Pediatr 2019 Jan 11. Epub 2019 Jan 11.

Chinese Evidence-based Medicine Center, Center for Clinical Epidemiology and Evidence-based Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.

Background: Fetal macrosomia, defined as birth weight equal or over 4000 g, is a major concern for both neonatal and maternal health. A rapid increasing trend in fetal macrosomia is observed in different regions of China. We aimed to examine the association between fetal macrosomia and risk of childhood obesity in Western China. Read More

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http://dx.doi.org/10.1007/s12519-018-0218-7DOI Listing
January 2019
2 Reads

Effect of Mild Hyperthermia on Transdermal Absorption of Nicotine from Patches.

AAPS PharmSciTech 2019 Jan 11;20(2):77. Epub 2019 Jan 11.

Department of Pharmaceutics and Drug Delivery, University of Mississippi, Oxford, Mississippi, 38677, USA.

Application of heat (hyperthermic conditions) on skin is known to enhance drug transfer and facilitate skin penetration of molecules. The aim of this work was to study the effect of hyperthermia on the drug release and skin permeation from nicotine transdermal patches. The drug release and skin permeation were characterized by in vitro release test and in vitro permeation test. Read More

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http://dx.doi.org/10.1208/s12249-019-1299-xDOI Listing
January 2019
2 Reads

Prediction-Based Compensation for Gate On/Off Latency during Respiratory-Gated Radiotherapy.

Comput Math Methods Med 2018 27;2018:5919467. Epub 2018 Nov 27.

Department of Radiology, University of Yamanashi, Japan.

During respiratory-gated radiotherapy (RGRT), gate on and off latencies cause deviations of gating windows, possibly leading to delivery of low- and high-dose radiations to tumors and normal tissues, respectively. Currently, there are no RGRT systems that have definite tools to compensate for the delays. To address the problem, we propose a framework consisting of two steps: (1) multistep-ahead prediction and (2) prediction-based gating. Read More

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http://dx.doi.org/10.1155/2018/5919467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288586PMC
November 2018
0.766 Impact Factor

Cystatin C as a novel predictor of preterm labor in severe preeclampsia.

Kidney Res Clin Pract 2018 Dec 31;37(4):338-346. Epub 2018 Dec 31.

Department of Internal Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.

Background: The most common cause of acute kidney injury (AKI) in pregnancy is preeclampsia. Serum cystatin C (CysC) is a potential biomarker of early kidney damage as its levels are not disturbed by volume status changes in pregnancy, and serum CysC levels could serve as a replacement for conventionally used creatinine. In this study, we investigated the serum levels of CysC in severe preeclampsia cases and the associations between CysC levels and poor obstetric outcomes. Read More

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http://www.krcp-ksn.org/journal/view.html?doi=10.23876/j.krc
Publisher Site
http://dx.doi.org/10.23876/j.krcp.18.0080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312773PMC
December 2018
2 Reads

Outcome of the vaginal birth after cesarean section during the second birth order in West Kazakhstan.

J Family Med Prim Care 2018 Nov-Dec;7(6):1542-1547

Department of Obstetrics and Gynecology, Marat Ospanov, West Kazakhstan State Medical University (WKSMU), Aktobe, Kazakhstan.

Background: Vaginal birth after cesarean section (VBAC) increases the chance of subsequent vaginal deliveries and reduces the repeat cesarean section (CS) rate with subsequent postoperative morbidity.

Objectives: To detect the outcome of VBAC during the second birth order in Aktobe region of West Kazakhstan.

Patients And Methods: A total of 832 women eligible for trial of VBAC were included in this study. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_293_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293889PMC
January 2019
1 Read

Folic acid receptor-targeted human serum albumin nanoparticle formulation of cabazitaxel for tumor therapy.

Int J Nanomedicine 2019 21;14:135-148. Epub 2018 Dec 21.

School of Life Sciences, Jilin University, Changchun, Jilin, China,

Background: We previously developed cabazitaxel (CTX)-loaded human serum albumin nanoparticles (NPs-CTX) via a self-assembly method, and these NPs showed efficacy in prostate cancer therapy. Many studies have shown that the levels of folic acid (FA) receptor on the surface of various tumor cells are high. Therefore, FA-modified NPs-CTX may have enhanced antitumor effects compared with unmodified NPs-CTX. Read More

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https://www.dovepress.com/folic-acid-receptor-targeted-human
Publisher Site
http://dx.doi.org/10.2147/IJN.S181296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306057PMC
February 2019
7 Reads

A photoacoustic shockwave triggers the size shrinkage of nanoparticles to obviously improve tumor penetration and therapeutic efficacy.

Nanoscale 2019 Jan;11(3):1423-1436

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China.

Drug delivery to a tumor site with an insufficient microvascular network remains a challenge due to the size preference for transport in terms of circulation and distribution. In this work, an integrated nano-therapeutic parcel disintegrable by a photoacoustic shockwave was developed. Nano-therapeutic particles with red absorbance are packaged into a larger parcel to generate a longer circulation half-life and improved accumulation in tumor tissue. Read More

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http://dx.doi.org/10.1039/c8nr08271eDOI Listing
January 2019
1 Read

Gene Therapy for Treatment of Chronic Hyperammonemia in a Rat Model of Hepatic Encephalopathy.

Ann Hepatol 2018 Oct;17(6):1026-1034

Departamento de Gastroenterología. Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico.

Introduction And Aim: Hepatic encephalopathy (HE), caused by hyperammonemia resulting from liver disease, is a spectrum of neuropsychiatric and motor disorders that can lead to death. Existing therapies are deficient and alternative treatments are needed. We have shown that gene therapy with a baculovirus vector containing the glutamine synthetase (Bac-GS) gene is efficient for reducing ammonia levels in an acute hyperammonemia rat model. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7203DOI Listing
October 2018
2 Reads

Potential use of aptamers for diagnosis and treatment of pancreatic cancer.

J Drug Target 2018 Dec 31:1-13. Epub 2018 Dec 31.

c Department of Chemistry , Waterloo Institute for Nanotechnology, University of Waterloo , Waterloo , Canada.

Pancreatic cancer (PC) is highly malignant with a low 5-year survival rate. PC currently does not have good early diagnostic markers and responses poorly to chemotherapeutic drugs. The search for better biomarkers and developing more effective chemotherapy are important ways to improve the healthcare of PC patients. Read More

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https://www.tandfonline.com/doi/full/10.1080/1061186X.2018.1
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http://dx.doi.org/10.1080/1061186X.2018.1564924DOI Listing
December 2018
9 Reads

Factors affecting labor duration in Chinese pregnant women.

Medicine (Baltimore) 2018 Dec;97(52):e13901

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of Education, Chengdu.

The aim of the study was to explore the role of parity, maternal age, medical interventions, and birth weight with respect to labor duration and cervical dilation.A total of 1601 pregnant women who had a singleton term gestation, spontaneous onset of labor, vertex presentation, vaginal delivery, and a normal perinatal outcome were reviewed. The retrospective study was conducted in patients from West China Second University Hospital of Sichuan University during June 2008 to June 2013. Read More

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http://dx.doi.org/10.1097/MD.0000000000013901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314697PMC
December 2018
17 Reads

Effects of maternal obesity on the success of assisted vaginal delivery in Chinese women.

BMC Pregnancy Childbirth 2018 Dec 27;18(1):509. Epub 2018 Dec 27.

Department of Gynaecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, 252000, Shandong Province, People's Republic of China.

Background: We examined the influence of pre-pregnancy body weight on the rates of attempted and successfully assisted-vaginal delivery.

Methods: We used 2008-2016 inpatient records including 3408 women who had singleton gestations and needed operative delivery assistance to conduct a retrospective cohort study. Patients were categorized based on pre-pregnancy BMI (normal weight = 18. Read More

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http://dx.doi.org/10.1186/s12884-018-2151-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307111PMC
December 2018
2 Reads

Foeto-placental parameters in normal pregnancy and factors affecting them.

Niger Postgrad Med J 2018 Oct-Dec;25(4):234-238

Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, Nigeria.

Objective: The aim of this study was to evaluate foeto-placental (F/P) parameters, namely foetal birth weight, placental weight (PW) and F/P weight ratio, in normal pregnancy and factors affecting them.

Methodology: A retrospective study was conducted on labour ward data obtained over a period of 3 years (2015-2017). Only deliveries above 28-week gestational age which met other selection criteria were included in the study. Read More

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http://dx.doi.org/10.4103/npmj.npmj_97_18DOI Listing
December 2018

Systematic review to investigate the safety of induction and augmentation of labour among pregnant women with iron-deficiency anaemia.

BMJ Open 2018 Dec 19;8(12):e021793. Epub 2018 Dec 19.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Objective: To conduct a systematic review to investigate the safety of induction and/or augmentation of labour compared with spontaneous-onset normal labour among pregnant women with iron-deficiency anaemia.

Design: Systematic review.

Setting: Studies from all countries, worldwide. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-021793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303660PMC
December 2018
1 Read

Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment.

Colloids Surf B Biointerfaces 2019 Mar 13;175:477-486. Epub 2018 Dec 13.

Department of Urology, Mindong Hospital Affiliated to Fujian Medical University, Fu'an, 355000, People's Republic of China.

Nanoparticular drug delivery system (NDDS) has great potential for enhancing the efficacy of traditional chemotherapeutic drugs. However, it is still a great challenge to fabricate a biocompatible NDDS with simple structure capable of optimizing therapeutic efficacy, such as high tumor accumulation, suitable drug release profile (e.g. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2018.12.038DOI Listing
March 2019
2 Reads

Normal delivery and cesarean section: cost per brazilian regions, 2015.

Rev Assoc Med Bras (1992) 2018 Nov;64(11):1045-1049

Universidade Federal do Rio Grande do Sul, Social Medicine Department, Porto Alegre, RS, Brasil.

Objective: To describe the number of funds made by the Brazilian National Health System to normal delivery and cesarean procedures, according to the Brazilian regions in 2015, and estimate the cost cutting if the recommendation concerning the prevalence of cesarean deliveries by the World Health Organization (10 to 15%) were respected.

Methods: Secondary analysis of data from the Hospital Information System of the Brazilian National Health System. The variables considered were the type of delivery (cesarean section and normal), geographic region of admission, length of stay and amount paid for admission in 2015. Read More

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http://dx.doi.org/10.1590/1806-9282.64.11.1045DOI Listing
November 2018
1 Read

Perineal prevention and protection in obstetrics: CNGOF clinical practice guidelines.

J Gynecol Obstet Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Obs/Gyn, Epidemiologist. INSERM CIC1402, Université de Poitiers, CHU de Poitiers, France. Electronic address:

Introduction: The objective of these clinical practice guidelines was to analyse all of the interventions during pregnancy and childbirth that might prevent obstetric anal sphincter injuries (OASIS) and postnatal pelvic floor symptoms.

Material And Methods: These guidelines were developed in accordance with the methods prescribed by the French Health Authority (HAS).

Results: A prenatal clinical examination of the perineum is recommended for women with a history of Crohn's disease, OASIS, genital mutilation, or perianal lesions (professional consensus). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687847183051
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http://dx.doi.org/10.1016/j.jogoh.2018.12.002DOI Listing
December 2018
9 Reads

Fabrication and evaluation of a γ-PGA-based self-assembly transferrin receptor-targeting anticancer drug carrier.

Int J Nanomedicine 2018 22;13:7873-7889. Epub 2018 Nov 22.

School of Life Sciences, East China Normal University, Shanghai 200241, China,

Background: cis-Dichlorodiamineplatinum (CDDP) was one of the most common used drugs in clinic for cancer treatment. However, CDDP caused a variety of side effects. The abundant carboxyl groups on the surface of poly glutamic acid (PGA) could be modified with various kinds of targeted ligands. Read More

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http://dx.doi.org/10.2147/IJN.S181121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255109PMC
January 2019

Tumor treating fields increases membrane permeability in glioblastoma cells.

Cell Death Discov 2018 5;4:113. Epub 2018 Dec 5.

1Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Room E150, 318 Campus Drive West, Stanford, CA 94305 USA.

Glioblastoma is the most common yet most lethal of primary brain cancers with a one-year post-diagnosis survival rate of 65% and a five-year survival rate of barely 5%. Recently the U.S. Read More

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http://dx.doi.org/10.1038/s41420-018-0130-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281619PMC
December 2018
1 Read

A placebo-controlled clinical trial to evaluate the effectiveness of massaging on infantile colic using a random-effects joint model.

Pediatric Health Med Ther 2018 16;9:157-163. Epub 2018 Nov 16.

Department of Midwifery and Reproductive Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Infantile colic viewed as a non-dangerous prevalent issue could lead to stress in parents and long-term negative consequences in ex-colicky children. Researchers have not been successful in finding a certain treatment for colic symptoms. Studies suggest completely different approaches as its treatment. Read More

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https://www.dovepress.com/a-placebo-controlled-clinical-tria
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http://dx.doi.org/10.2147/PHMT.S185214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247972PMC
November 2018
2 Reads

Severe neutropenia in a breastfed infant: a case report and discussion of the differential diagnosis.

Int Med Case Rep J 2018 15;11:333-337. Epub 2018 Nov 15.

Department of Pediatrics, Queen Paola Children's Hospital, Antwerp, Belgium,

Neonatal neutropenia is regularly seen with variable etiology. We describe a breastfed infant with maternal medication use as a probable cause of neonatal neutropenia. An 8 days old exclusively breastfed female infant of Arab-Berber descent was referred to our hospital because of an infection of the umbilicus. Read More

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http://dx.doi.org/10.2147/IMCRJ.S173826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245346PMC
November 2018

Draft Opioid-Prescribing Guidelines for Uncomplicated Normal Spontaneous Vaginal Birth.

Obstet Gynecol 2019 Jan;133(1):81-90

University of Illinois at Chicago, Chicago, Illinois; Novartis Oncology, East Hanover, New Jersey; U.S. Department of Health and Human Services, Washington, DC; and Premier, Inc, Charlotte, North Carolina.

Women who experience an uncomplicated vaginal delivery have acute intrapartum pain and variable pain in the immediate postpartum period. Although the Centers for Disease Control and Prevention (CDC) has urged clinicians to improve opioid-prescribing behavior, there are no published clinical practice guidelines for prescribing opioids during labor and delivery and at discharge for patients with uncomplicated normal spontaneous vaginal delivery. To address the knowledge gap regarding guidelines for pain management in this population, we used the national Premiere Health Care Database for deliveries of uncomplicated vaginal births from January 1, 2014, to December 31, 2016, to determine the prevalence of opioid administration. Read More

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http://dx.doi.org/10.1097/AOG.0000000000002996DOI Listing
January 2019
10 Reads

Amniotic fluid and umbilical cord serum erythropoietin in term and prolonged pregnancies.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 3;233:1-5. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Finland.

Objective: Erythropoietin - a hormone regulating erythropoiesis - is a biomarker of chronic fetal hypoxia. High erythropoietin levels in fetal plasma and amniotic fluid are associated with increased risk of adverse neonatal outcome. Since the risk of perinatal morbidity and mortality is increased in pregnancies beyond 41 gestational weeks, we evaluated erythropoietin levels in amniotic fluid and umbilical cord serum in apparently low-risk term (≥ 37 gestational weeks) and prolonged pregnancies (≥ 41 gestational weeks) with labor induction. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.11.022DOI Listing
February 2019
2 Reads

Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues.

Acta Biomater 2018 Dec 6. Epub 2018 Dec 6.

Department of Bioengineering, Northeastern University, Boston, MA, USA; Department of Mechanical Engineering, Northeastern University, Boston, MA, USA. Electronic address:

Drug delivery to avascular, negatively charged tissues like cartilage remains a challenge. The constant turnover of synovial fluid results in short residence time of administered drugs in the joint space and the dense negatively charged matrix of cartilage hinders their diffusive transport. Drugs are, therefore, unable to reach their cell and matrix targets in sufficient doses, and fail to elicit relevant biological response, which has led to unsuccessful clinical trials. Read More

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http://dx.doi.org/10.1016/j.actbio.2018.12.004DOI Listing
December 2018
1 Read
6.025 Impact Factor

ED of intrathecal ropivacaine for cesarean delivery with and without epidural volume extension with normal saline: a randomized controlled study.

Authors:
M Lv P Zhang Z Wang

J Pain Res 2018 8;11:2791-2796. Epub 2018 Nov 8.

Institute of Clinical Research, Jiaxing university, Jiaxing, China,

Background: It was reported that epidural volume extension could decrease the ED of intrathecal plain bupivacaine. In this study, we investigated the ED of intrathecal hyperbaric ropivacaine followed by epidural normal saline bolus for cesarean section.

Methods: Sixty parturients were allocated into two groups in this prospective study. Read More

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http://dx.doi.org/10.2147/JPR.S174176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235342PMC
November 2018
1 Read

[Effect of oxytocin on the levels of malondialdehyde, nitric oxide, and s100b protein in newborns].

Rev Peru Med Exp Salud Publica 2018 Jul-Sep;35(3):449-455

. Hospital III Yanahuara. Arequipa, Perú.

Objectives: To assess the effects of the administration of oxytocin during labor management on the levels of malondialdehyde (MDA), nitric oxide (NO), and S100B protein in newborns.

Materials And Methods: We selected 80 term pregnant women without obstetric and fetal pathology, forming two groups: pregnant women with normal delivery and pregnant women conducted with oxytocin. Blood was collected immediately after delivery from the umbilical cord vein to measure MDA, ON and from the artery for protein S100B. Read More

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http://dx.doi.org/10.17843/rpmesp.2018.353.3305.DOI Listing
December 2017
1 Read

Respectful and disrespectful care in the Czech Republic: an online survey.

Reprod Health 2018 Dec 4;15(1):198. Epub 2018 Dec 4.

School of Nursing and Midwifery, Trinity College Dublin, 24 D'Olier Street, Dublin, DO2 T283, Ireland.

Background: Respectful maternity care includes treating women with dignity, consulting them about preferences, gaining consent for treatment, respecting their wishes, and giving care based on evidence, not routines. In the absence of any documented evidence, this study aimed to ascertain maternity care-givers' perceptions of respectful care provided for childbearing women in Czech Republic.

Methods: Following ethical approval, an online quantitative survey with qualitative comments was completed by 52 respondents recruited from workshops on promoting normal birth, followed by snowball sampling. Read More

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https://reproductive-health-journal.biomedcentral.com/articl
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http://dx.doi.org/10.1186/s12978-018-0648-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280471PMC
December 2018
8 Reads

Gelatin-epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief.

Int J Nanomedicine 2018 8;13:7251-7273. Epub 2018 Nov 8.

Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei City, Taiwan,

Introduction: Dry-eye syndrome (DES) is a general eye disease. Eye drops are the common ophthalmological medication. However, the ocular barrier makes it difficult to attain high drug bioavailability. Read More

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https://www.dovepress.com/gelatinndashepigallocatechin-galla
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http://dx.doi.org/10.2147/IJN.S173198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231513PMC
January 2019
15 Reads

Understanding the size effect of graphene quantum dots on protein adsorption.

Colloids Surf B Biointerfaces 2019 Feb 24;174:575-581. Epub 2018 Nov 24.

College of Life Information Science and Instrument Engineering, Hangzhou Dianzi University, Hangzhou, 310018, People's Republic of China. Electronic address:

Due to the unique structural and mechanical properties, graphene quantum dots (GQDs) are considered as potential candidates in the field of biosensors, bioimaging, and drug delivery etc. In this work, the adsorption of protein villin headpiece (HP35) on GQDs with different sizes was investigated by molecular dynamics simulations. The simulation results identified the key role of the π-π stacking interactions between the aromatic residues of HP35 and GQDs as the binding site. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2018.11.059DOI Listing
February 2019

Early Pregnancy Hemoglobin A1C and Pregnancy Outcomes: A Population-Based Study.

Am J Perinatol 2018 Nov 30. Epub 2018 Nov 30.

Kaiser Permanente Washington Health Research Institute, Seattle, Washington.

Objectives:  Women with prediabetes are identified from screening for overt diabetes in early pregnancy, but the clinical significance of prediabetes in pregnancy is unclear. We examined whether prediabetes in early pregnancy was associated with risks of adverse outcomes.

Study Design:  We conducted a retrospective cohort study of pregnant women enrolled in Kaiser Permanente Washington from 2011 to 2014. Read More

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http://dx.doi.org/10.1055/s-0038-1675619DOI Listing
November 2018
2 Reads

Encapsulation of ciprofloxacin within modified xanthan gum- chitosan based hydrogel for drug delivery.

Bioorg Chem 2019 Mar 22;84:115-124. Epub 2018 Nov 22.

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.

The aim of the present work was to investigate the preparation of polyelectrolyte hydrogel as potential drug carrier for antibacterial Ciprofloxacin drug (CFX), intended for controlled release formulation. Hydrogel of N-trimehtyl chitosan (TMC)/sodium carboxymethyl xanthan gum (CMXG) was prepared and ciprofloxacin was employed as a model drug to investigate the loading and release performance of the prepared hydrogel. FTIR, DSC, TGA and SEM analysis were used to characterize the TMC/CMXG hydrogel and its CFX loaded hydrogel. Read More

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http://dx.doi.org/10.1016/j.bioorg.2018.11.036DOI Listing
March 2019
7 Reads