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Sci Rep 2020 May 21;10(1):8419. Epub 2020 May 21.

Computational Health Informatics Program, Boston Children's Hospital, Boston, USA.

Childhood epilepsy with centrotemporal spikes, previously known as Benign Epilepsy with Centro-temporal Spikes (BECTS) or Rolandic Epilepsy, is one of the most common forms of focal childhood epilepsy. Despite its prevalence, BECTS is often misdiagnosed or missed entirely. This is in part due to the nocturnal and brief nature of the seizures, making it difficult to identify during a routine electroencephalogram (EEG). Read More

Sleep 2020 May 15. Epub 2020 May 15.

Center for Investigation and Research on Sleep, Lausanne University Hospital (CHUV), Switzerland.

Feeling awake although sleep recordings indicate clear-cut sleep occurs sometimes in good sleepers and to an extreme degree in patients with so-called paradoxical insomnia. It is unknown what underlies sleep misperception, as standard polysomnographic (PSG) parameters are often normal in these cases. Here we asked whether regional spectral power changes could account for the mismatch between objective and subjective total sleep times (TST). Read More

Clin Neurophysiol 2020 May 13;131(5):1030-1039. Epub 2020 Feb 13.

Danish Epilepsy Centre, Dianalund, Denmark; University of Copenhagen, Copenhagen, Denmark. Electronic address:

Objective: To investigate the clinical and EEG features of Encephalopathy with Status Epilepticus during slow Sleep (ESES) related to CNKSR2 pathogenic variants.

Methods: Detailed clinical history, repeated wakefulness/overnight sleep EEGs, brain MRI were collected in five patients, including one female, with CNKSR2-related ESES.

Results: Neurodevelopment in infancy was normal in two patients, delayed in three. Read More

Front Cardiovasc Med 2020 21;7:19. Epub 2020 Feb 21.

Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, Adelaide, SA, Australia.

Cardiac function is modulated by multiple factors including exogenous (circadian rhythm) and endogenous (ultradian 90-110 min sleep cycle) factors. By evaluating heart rate variability (HRV) during sleep, we will better understand their influence on cardiac activity. The aim of this study was to evaluate HRV in the dark phase of the circadian rhythm during sleep in healthy children and adolescents. Read More

Brain Cogn 2020 04 3;140:105535. Epub 2020 Feb 3.

Scientific Institute IRCCS "Eugenio Medea", Polo FVG, San Vito al Tagliamento (PN), Italy. Electronic address:

We developed a junior-real-time neuropsychological testing (j-RTNT) and used it during surgery of a right fronto-insular dysembryoplastic neuroepithelial tumor causing seizures in a 16 years old female. The j-RTNT included tasks from the battery NEPSY-II. Pre-surgery evaluation detected a below average performance in visuo-spatial planning, inhibition, visual attention, planning and borderline performance in speeded naming. Read More

Sci Rep 2020 Jan 29;10(1):1449. Epub 2020 Jan 29.

Laboratory of Functional Neuroscience, Pablo de Olavide University, Seville, 41013, Spain.

Sleep is thought to play a complementary role in human memory processing: sleep loss impairs the formation of new memories during the following awake period and, conversely, normal sleep promotes the strengthening of the already encoded memories. However, whether sleep can strengthen deteriorated memories caused by insufficient sleep remains unknown. Here, we showed that sleep restriction in a group of participants caused a reduction in the stability of EEG activity patterns across multiple encoding of the same event during awake, compared with a group of participants that got a full night's sleep. Read More

Epilepsy Behav 2020 01 20;102:106642. Epub 2019 Nov 20.

Weill Cornell Medicine, Department of Psychiatry, 1300 York Avenue, New York, NY 10065, United States; New York-Presbyterian Hospital Westchester Division, 21 Bloomingdale Road, White Plains, NY 10605, United States.

Psychogenic nonepileptic seizures (PNES) are challenging clinical occurrences consisting of any combination of altered movement, sensation, or awareness that resemble epileptic seizures (ES) but do not coincide with electrographic ictal discharges and are presumed to be neuropsychiatric-neurobehavioral in origin. Securing the PNES diagnosis is a crucial first step and is best confirmed by recording events on video-electroencephalogram (v-EEG) and finding an absence of ictal EEG changes and the presence of normal awake EEG rhythms before, during, and after the event. However, obstacles to timely diagnosis and referral to psychiatric treatment frequently occur, placing these patients at risk for harm from unnecessary medications and procedure as well as placing high burden on medical systems. Read More

Neurol Sci 2020 Mar 16;41(3):631-636. Epub 2019 Nov 16.

Department of Pediatric Metabolism, Faculty of Medicine, Mayıs University, Samsun, Turkey.

Objective: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism. MTHFR C677T and A1298C polymorphisms are best-defined variants of MTHFR that were reported to be associated with epilepsy development. The aim of the study was to determine the incidence of interictal epileptiform discharges on electroencephalography (EEG) in asymptomatic children with C677T and A1298C polymorphisms who had no history of seizure. Read More

Neuroimage 2020 02 12;206:116338. Epub 2019 Nov 12.

A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. Electronic address:

Functional magnetic resonance imaging (fMRI) studies in animal models provide invaluable information regarding normal and abnormal brain function, especially when combined with complementary stimulation and recording techniques. The echo planar imaging (EPI) pulse sequence is the most common choice for fMRI investigations, but it has several shortcomings. EPI is one of the loudest sequences and very prone to movement and susceptibility-induced artefacts, making it suboptimal for awake imaging. Read More

Curr Biol 2019 12 24;29(23):4078-4083.e2. Epub 2019 Oct 24.

State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China. Electronic address:

Neuronal responses in the primary visual cortex (V1) are driven by simple stimuli, but these stimulus-evoked responses can be markedly modulated by non-sensory factors, such as attention and reward [1], and shaped by perceptual training [2]. In real-life situations, neutral visual stimuli can become emotionally tagged by experience, resulting in altered perceptual abilities to detect and discriminate these stimuli [3-5]. Human imaging [4] and electroencephalography (EEG) studies [6-9] have shown that visual fear learning (the acquisition of aversive emotion associated with a visual stimulus) affects the activities in visual cortical areas as early as in V1. Read More

J Clin Sleep Med 2019 08;15(8):1155-1163

Cerebra Health Inc., Winnipeg, Canada.

Study Objectives: The Odds Ratio Product (ORP) is an objective measure of sleep depth using the relationships of the powers of different electroencephalogram (EEG) frequencies in a single index. The range of the ORP is 0 (deeply asleep) to 2.5 (fully awake). Read More

J Clin Neurophysiol 2019 Jul;36(4):250-256

Department of Neurology, Jefferson Comprehensive Epilepsy Center, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.

Knowledge of normal patterns is essential for correct EEG interpretation. The overinterpretation of EEG (i.e. Read More

Epilepsia Open 2019 Jun 4;4(2):254-263. Epub 2019 Mar 4.

Department of Neurosurgery Anschutz School of Medicine University of Colorado Denver Aurora Colorado.

Objective: Temporal lobe epilepsy (TLE) is often associated with memory deficits. Reactivation of memory traces in the hippocampus occurs during sharp-wave ripples (SWRs; 140-250 Hz). To better understand the mechanisms underlying high-frequency oscillations and cognitive comorbidities in epilepsy, we evaluated how rigorously identified deep CA1 pyramidal cells (dPCs) discharge during SWRs in control and TLE mice. Read More

Epilepsy Behav 2019 06 24;95:87-94. Epub 2019 Apr 24.

Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, VT 05405, USA. Electronic address:

Objective: There is increasing evidence that Autism Spectrum Disorder (ASD) is a disorder of functional connectivity with both human and rodent studies demonstrating alterations in connectivity. Here, we hypothesized that early-life seizures (ELS) in rats would interrupt normal brain connectivity and result in autistic-like behavior (ALB).

Methods: Following 50 seizures, adult rats were tested in the social interaction and social novelty tests and then underwent qualitative and quantitative intracranial electroencephalography (EEG) monitoring in the medial prefrontal cortex (PFC) and the hippocampal subfields, CA3 and CA1. Read More

Epilepsy Res 2019 07 27;153:28-33. Epub 2019 Mar 27.

Department of Neurology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.

Purpose: The aim of this study was to analyze patients whose only manifestation of epilepsy were generalized tonic-clonic seizures (GTCS) during childhood and discuss its validity as separate syndrome of childhood.

Methods: We included children with at least two unprovoked GTCS between 3 and 11 years of age, no other seizure types at diagnosis, normal psychomotor development and neurological examination, an EEG with normal background and paroxysms of generalized spikes and waves with a frequency 2.5 Hz or above, and an unknown cause for epilepsy. Read More

World Neurosurg 2019 06 1;126:134-138. Epub 2019 Mar 1.

Department of Neurosurgery, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA.

Background: Slit-ventricle syndrome (SVS) is a recognized complication of ventricular shunt malfunction, resulting in cyclical symptoms without ventricular dilatation. We present a case of SVS with transient, repetitive, and progressive signs of brainstem herniation evidenced by pupillary dilatation, posturing, and unresponsiveness, with diffuse voltage attenuation on electroencephalogram (EEG).

Case Description: A 32-year-old female presented with a history of hydrocephalus and ventriculoperitoneal shunt placement at 9 months of age. Read More

J Neurosci 2019 02 14;39(6):1119-1134. Epub 2018 Dec 14.

MRC Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom,

Synchronized oscillations within and between brain areas facilitate normal processing, but are often amplified in disease. A prominent example is the abnormally sustained beta-frequency (∼20 Hz) oscillations recorded from the cortex and subthalamic nucleus of Parkinson's disease patients. Computational modeling suggests that the amplitude of such oscillations could be modulated by applying stimulation at a specific phase. Read More

Front Neurosci 2018 13;12:809. Epub 2018 Nov 13.

Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States.

Sleep electroencephalography (EEG) provides an opportunity to study sleep scientifically, whose chaotic, dynamic, complex, and dissipative nature implies that non-linear approaches could uncover some mechanism of sleep. Based on well-established complexity theories, one hypothesis in sleep medicine is that lower complexity of brain waves at pre-sleep state can facilitate sleep initiation and further improve sleep quality. However, this has never been studied with solid data. Read More

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:5422-5425

We have designed and developed a novel, noninvasive modular headmount to be used for awake animal scalp electroencephalography (EEG). The design is based on a developing rat that will accommodate rapid head growth. Desired characteristics include non-invasiveness, adjustable quantity and positioning, light weight, and tolerability by the animal. Read More

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:3052-3055

Electrocorticogram (ECoG) has been used as a reliable modality to control a brain machine interface (BMI). Recently, promising results of high-density ECoG have shown that non redundant information can be recorded with finer spatial resolution from the cortical surface. In this study, highdensity ECoG was recorded intraoperatively from two patients during awake brain surgery while performing instructed hand flexion and extension. Read More

PLoS One 2018 6;13(11):e0207031. Epub 2018 Nov 6.

Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America.

The neonatal brain undergoes rapid maturational changes that facilitate the normal development of the nervous system and also affect the pathological response to brain injury. Electroencephalography (EEG) and analysis of sleep-wake vigilance states provide important insights into the function of the normal and diseased immature brain. While developmental changes in EEG and vigilance states are well-described in people, less is known about the normal maturational properties of rodent EEG, including the emergence and evolution of sleep-awake vigilance states. Read More

Sci Rep 2018 09 7;8(1):13471. Epub 2018 Sep 7.

School of Life Sciences, Tsinghua University, Beijing, 100086, China.

State-dependent memory describes a phenomenon that memory will be efficiently retrieved only when the brain state during retrieval matches the state during encoding. While a variety of psychoactive drugs, such as ethanol, cocaine, morphine and NMDA receptor antagonists, are able to induce state-dependent memory, the biological hallmark of brain state and neural mechanism of its regulation are still unknown. In this study, we found that MK-801 enhanced delta oscillations in awake mice, representing a drug-induced brain state, in which fear memory could only be successfully retrieved when the same drug condition was presented. Read More

J Neurosci 2018 10 27;38(41):8772-8786. Epub 2018 Aug 27.

Department of Pharmacology and Physiology, and Institute for Neuroscience, George Washington University, Washington, DC 20037

Two major checkpoints of development in cerebral cortex are the acquisition of continuous spontaneous activity and the modulation of this activity by behavioral state. Despite the critical importance of these functions, the circuit mechanisms of their development remain unknown. Here we use the rodent visual system as a model to test the hypothesis that the locus of circuit change responsible for the developmental acquisition of continuity and state dependence measured in sensory cortex is relay thalamus, rather than the local cortical circuitry or the interconnectivity of the two structures. Read More

Anesthesiology 2018 11;129(5):942-958

From Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Direction de la Recherche Fondamentale, NeuroSpin Center, Gif-sur-Yvette, France (L.U., A.J., J.T., P.B., M.D., S.D., B.J.) Cognitive Neuroimaging Unit, Institut National de la Santé et de la Recherche Médicale U992, Gif-sur-Yvette, France (L.U., A.J., J.T., P.B., M.D., S.D., B.J.) Department of Anesthesiology and Critical Care, Necker Hospital, University Paris Descartes, Paris, France (L.U.) Department of Anesthesiology and Critical Care, Sainte-Anne Hospital, University Paris Descartes, Paris, France (L.U.) Institut National de la Santé et de la Recherche Médicale U1127, Paris, France (J.D.S.) Physiological Investigations of Clinically Normal and Impaired Cognition Lab, Institut du Cerveau et de la Moelle épinière, Paris, France (J.D.S.) Collège de France, Paris, France (S.D.) Université Paris Sud, Université Paris-Saclay, Orsay, France (S.D.) Neurosurgery Department, Foch Hospital, Suresnes, France (B.J.) the University of Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Versailles, France (B.J.).

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: The mechanism by which anesthetics induce a loss of consciousness remains a puzzling problem. We hypothesized that a cortical signature of anesthesia could be found in an increase in similarity between the matrix of resting-state functional correlations and the anatomical connectivity matrix of the brain, resulting in an increased function-structure similarity.

Methods: We acquired resting-state functional magnetic resonance images in macaque monkeys during wakefulness (n = 3) or anesthesia with propofol (n = 3), ketamine (n = 3), or sevoflurane (n = 3). Read More

Korean J Anesthesiol 2019 04 30;72(2):169-177. Epub 2018 May 30.

Department of Anesthesia, Assiut University Hospital, Egypt & Hamad Medical Corporation, Weill Cornell Medicine-Qatar, Doha, Qatar.

Background: Autism is a challenging neurodevelopmental disorder. Previous clinical observations have suggested altered sedation requirements for children with autism. Our study aimed to test this observation experimentally in an animal model and to explore its possible mechanisms. Read More

Front Hum Neurosci 2018 13;12:142. Epub 2018 Apr 13.

Laboratory for Human Brain Dynamics, AAI Scientific Cultural Services Ltd., Nicosia, Cyprus.

Neurofeedback has been around for half a century, but despite some promising results it is not yet widely appreciated. Recently, some of the concerns about neurofeedback have been addressed with functional magnetic resonance imaging and magnetoencephalography adding their contributions to the long history of neurofeedback with electroencephalography. Attempts to address other concerns related to methodological issues with new experiments and meta-analysis of earlier studies, have opened up new questions about its efficacy. Read More

Biomed Pharmacother 2018 Mar 20;99:913-920. Epub 2018 Feb 20.

Department of Public Health Sciences, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

The aim of this study was to investigate the beneficial effect of Valerian/Cascade mixture on sleeping in mammal models. In pentobarbital-induced sleep model, Valerian, Cascade, and Valerian/Cascade mixture significantly reduced the latency time for sleeping, and total sleeping time effectively increased in these sample groups compared with the control. Valerian/Cascade mixture increased sleep duration by 37%. Read More

Brain 2018 04;141(4):1130-1144

Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

In contrast to scalp EEG, our knowledge of the normal physiological intracranial EEG activity is scarce. This multicentre study provides an atlas of normal intracranial EEG of the human brain during wakefulness. Here we present the results of power spectra analysis during wakefulness. Read More

Georgian Med News 2017 Nov(272):104-109

M. Iashvili Children Central Hospital; David Tvildiani Medical University; Institute of Neurology and Neuropsychology, Tbilisi, Georgia.

West syndrome hasn't been thoroughly investigated in Georgia. The purposes of our study were a) to assess the clinical and etiological peculiarities of West syndrome, based on MRI data and its relation to the long-term outcome; b) to assess the evolution of West syndrome and its relation to patient characteristics; c) to compare the efficacies of treatments with ACTH and antiepileptic drugs (AEDs); d) to evaluate the neuropsychological outcome after 12 and 24 months and their early predictors. We evaluated 31 patients (17 male, 14 female) with infantile spasms. Read More

J Neurosci 2017 11 16;37(46):11220-11232. Epub 2017 Oct 16.

Department of Psychology, University of Sheffield, Cathederal Court, Sheffield, S1 1HD, United Kingdom.

Brief epochs of beta oscillations have been implicated in sensorimotor control in the basal ganglia of task-performing healthy animals. However, which neural processes underlie their generation and how they are affected by sensorimotor processing remains unclear. To determine the mechanisms underlying transient beta oscillations in the LFP, we combined computational modeling of the subthalamo-pallidal network for the generation of beta oscillations with realistic stimulation patterns derived from single-unit data recorded from different basal ganglia subregions in rats performing a cued choice task. Read More

Epilepsy Behav 2017 11 3;76:101-104. Epub 2017 Sep 3.

Department of Neurology, Vanderbilt University, Nashville TN, USA.

Objective: To study generalized paroxysmal fast activity (GPFA) in patients with genetic generalized epilepsy (GGE).

Introduction: GPFA is an electroencephalographic (EEG) finding in patients with symptomatic generalized epilepsy consisting of 15-25Hz bifrontally predominant generalized fast activity seen predominantly in sleep. Historically GPFA is linked to epileptic encephalopathy with drug resistant epilepsy and intellectual disability. Read More

Am J Physiol Regul Integr Comp Physiol 2017 Sep 21;313(3):R280-R289. Epub 2017 Jun 21.

Department of Neuroscience and Behavioral Neuroendocrinology Group, The Ohio State University Wexner Medical Center, Columbus, Ohio.

The long-term consequences of early life nicotine exposure are poorly defined. Approximately 8-10% of women report smoking during pregnancy, and this may promote aberrant development in the offspring. To this end, we investigated potential enduring effects of perinatal nicotine exposure on murine sleep and affective behaviors in adulthood (~13-15 wk of age) in C57Bl6j mice. Read More

Oman Med J 2017 May;32(3):256-258

Department of Neurology, King's Neuroscience Centre, King's College Hospital, London, UK.

Objectives: A measure to increase the electroencephalogram (EEG) outcome includes a short period of nap sleep during a routine standard EEG with the aim of increasing its sensitivity to interictal abnormalities or provoking seizures. As part of an ongoing auditing of our EEG data, we aimed to investigate the contribution of nap sleep during routine outpatient department based EEGs requested for a variety of reasons.

Methods: EEG data at the Department of Clinical Physiology at Sultan Qaboos University Hospital, Oman, from July 2006 to December 2007 and from January 2009 to December 2010 (total 42 months) were reviewed. Read More

Sleep Med 2017 Jun 14;34:1-6. Epub 2017 Mar 14.

Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark. Electronic address:

Objective: To compare diurnal and nocturnal electrophysiological data from narcolepsy patients with undetectable (<20 pg/mL), low (20-110 pg/mL) and normal (>110 pg/mL) cerebrospinal fluid (CSF) hypocretin-1 levels.

Patients/methods: A total of 109 narcolepsy patients and 37 controls were studied; all had available CSF hypocretin-1 measurements. The sleep laboratory studies were conducted between 2008 and 2014. Read More

Conf Proc IEEE Eng Med Biol Soc 2016 08;2016:4487-4490

Multimodal brain monitoring is an important approach to gain insight into brain function, modulation, and pathology. We have developed a unique micromachined neural probe capable of real-time continuous monitoring of multiple physiological, biochemical and electrophysiological variables. However, to date, it has only been used in anesthetized animals due to a lack of an appropriate interface for awake animals. Read More

Conf Proc IEEE Eng Med Biol Soc 2016 08;2016:2307-2310

In this work we propose a detailed EEG epoch selection method and compare epochs with rare and abundant alpha rhythm (AR) of patients with Alzheimer's disease (AD) and normal controls. Epochs were classified as Dominant Alpha Scenario (DAS) and Rare Alpha Scenario (RAS) according to the AR percentage (energy within the 8-13 Hz bandwidth) in O1, O2 and Oz electrodes. Participants were divided into four groups: 17 DAS controls (N1), 15 DAS mild-AD patients (AD1), 12 RAS controls (N2) and 15 RAS mild-AD patients (AD2). Read More

J Neural Eng 2017 04 4;14(2):026001. Epub 2017 Jan 4.

Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague, Zikova street 1903/4, 166 36 Prague 6, Czech Republic. Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

Objective: Automated behavioral state classification can benefit next generation implantable epilepsy devices. In this study we explored the feasibility of automated awake (AW) and slow wave sleep (SWS) classification using wide bandwidth intracranial EEG (iEEG) in patients undergoing evaluation for epilepsy surgery.

Approach: Data from seven patients (age [Formula: see text], 4 women) who underwent intracranial depth electrode implantation for iEEG monitoring were included. Read More

Hear Res 2017 02 9;344:13-23. Epub 2016 Nov 9.

School of Biological Sciences and Integrative Physiology and Neuroscience, Washington State University, Vancouver, WA, USA.

The neurochemical serotonin (5-hydroxytryptamine, 5-HT) is involved in a variety of behavioral functions including arousal, reward, and attention, and has a role in several complex disorders of the brain. In the auditory system, 5-HT fibers innervate a number of subcortical nuclei, yet the modulatory role of 5-HT in nearly all of these areas remains poorly understood. In this study, we examined spiking activity of neurons in the dorsal cochlear nucleus (DCN) following iontophoretic application of 5-HT. Read More

J Clin Neurophysiol 2017 Jan;34(1):69-76

*Coastal Neurology Services, Wentworth Douglass Hospital, Dover, NH; †Department of Neurology, UCLA, Los Angeles, California, U.S.A.; and ‡Tulane University School of Medicine, New Orleans, LA.

Purpose: The EEG rhythms demonstrate changes in frequency and power with spontaneous changes in behavioral state that do not have well-understood metabolic correlates within the brain. To investigate this question and compare the temporal lobe theta and delta rhythms, resting-state functional MRI was obtained with simultaneous EEG.

Methods: Simultaneous EEG-functional MRI was recorded from 14 healthy sleep-deprived subjects in awake and drowsy states. Read More

Int J Cardiol 2016 Dec 30;225:65-72. Epub 2016 Sep 30.

Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Background: Autonomic imbalance with increased sympathetic and decreased parasympathetic activities is observed in patients after myocardial infarction (MI). We aimed to investigate sleep-related changed in autonomic regulation in left coronary artery (LCA) ligation rats.

Methods: Wireless transmission of polysomnographic recording was performed in sham and LCA ligation male rats during normal daytime sleep with and without atenolol treatment. Read More

Int J Geriatr Psychiatry 2016 10 23;31(10):1124-35. Epub 2016 Aug 23.

Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, Stanford, CA, USA.

Objective: This investigation sought to determine whether delta activity at sleep onset (DASO) in the sleep electroencephalography of older adults represents normal variation or is associated with clinical pathology. To this end, we examined its longitudinal associations with cognitive and affective function in older adults without dementia.

Methods: Participants were 153 community-dwelling older adults without dementia. Read More

Ear Hear 2017 Jan/Feb;38(1):94-102

School of Audiology and Speech Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: Newborns reliably orient to sound location soon after birth; by age 1 month this orienting disappears until after age 4 months. It has been suggested that orienting by the newborn reflects subcortical-mediated reflexes, which are suppressed by age 1 month; reappearance of orienting then occurs after age 4 months with maturation of cortical mechanisms of sound localization. In the present study, we assess auditory lateralization in young infants (and adults) by recording slow cortical auditory evoked potentials to lateralization shifts in dichotic noise produced by changes in interaural time difference (ITD). Read More

Physiol Meas 2016 07 31;37(7):981-9. Epub 2016 May 31.

Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.

This study investigates the cerebral hemodynamic changes during a routine sleep-deprived video-electroencephalogram (SD-VEEG) in healthy children. Forty-two children with normal intelligence were examined. The children were 5-14 years of age, and their electroencephalograms (EEGs) were within the normal range. Read More

Exp Neurol 2016 Sep 27;283(Pt A):39-48. Epub 2016 May 27.

Laboratory of Cerebrovascular Mechanisms of Brain Disorders, Department of Neuroscience, Institute of functional Genomics, France. Electronic address:

Nuclear receptors (NRs) are a group of transcription factors emerging as players in normal and pathological CNS development. Clinically, an association between the constitutive androstane NR (CAR) and cognitive impairment was proposed, however never experimentally investigated. We wished to test the hypothesis that the impact of CAR on neurophysiology and behavior is underlined by cerebrovascular-neuronal modifications. Read More

Clin EEG Neurosci 2017 Jan 22;48(1):54-59. Epub 2016 Apr 22.

School of Medicine, Marmara University, Department of Neurology, Istanbul, Turkey.

Sarcoidosis is a multisystem granulomatous disease affecting nervous system in 5% to 10% of patients. Magnetic resonance imaging (MRI) is accepted as the most sensitive method for detecting neurosarcoidosis. However, the most common findings in MRI are the nonspecific white matter lesions, which may be unrelated to sarcoidosis and can occur because of hypertension, diabetes mellitus, smoking, and other inflammatory or infectious disorders, as well. Read More

Zhonghua Er Ke Za Zhi 2016 Mar;54(3):192-6

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

Objective: To investigate electroencephalographic (EEG) characteristics of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis in children.

Method: Clinical data of 28 children diagnosed as anti-NMDAR encephalitis were retrospectively analyzed for EEG characteristics in different periods and severity of disease and outcome.

Result: Among the 28 patients with anti-NMDAR encephalitis, 15 were males and 13 were females. Read More

J Alzheimers Dis 2016 ;51(1):21-6

Alzheimer's disease has been shown to affect vision in human patients and animal models. This may pose the risk of bias in behavior studies and therefore requires comprehensive investigation. We recorded electroretinography (ERG) under isoflurane anesthesia and visual evoked potentials (VEP) in awake amyloid expressing AβPPswe/PS1dE9 (AβPP/PS1) and wild-type littermate mice at a symptomatic age. Read More

J Clin Neurophysiol 2016 Aug;33(4):367-72

*Department of Neuroscience and Biomedical Engineering, School of Science, Aalto University, Espoo, Finland; †Elekta Oy, Helsinki, Finland; ‡MEG Core, Aalto Neuroimaging, Aalto University, Espoo, Finland; and §Departments of Clinical Neurosciences and Neurology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

Purpose: Detection of pathologic slow-wave oscillations (0.5-7 Hz) in awake subjects has gained increasing interest in clinical diagnostics. Their significance, however, is hampered by the occasional presence of slow waves in healthy subjects, as well as the abundance of artefactual signals at low measurement frequencies. Read More

Sci Rep 2015 Dec 9;5:17847. Epub 2015 Dec 9.

State Key Laboratory of Cognitive Neuroscience &Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.

Neural oscillatory activities have been shown to play important roles in neural information processing and the shaping of circuit connections during development. However, it remains unknown whether and how specific neural oscillations emerge during a postnatal critical period (CP), in which neuronal connections are most substantially modified by neural activity and experience. By recording local field potentials (LFPs) and single unit activity in developing primary visual cortex (V1) of head-fixed awake mice, we here demonstrate an emergence of characteristic oscillatory activities during the CP. Read More

Epilepsy Behav 2015 Dec 30;53:78-82. Epub 2015 Oct 30.

The First Affiliated Hospital of Anhui Medical University, PR China. Electronic address:

Benign epilepsy affecting children with normal mental development often occurs at a particular age, responds well to medication, and could be resolved completely by puberty. Although several studies have shown neuropsychological disabilities of children with benign epilepsy with centrotemporal spikes (BECTS), there is no clear evidence about the impairment of attentional systems and the comorbidity of attentional problems. Our research was based on the attention network model and assessed the characteristics of three anatomically defined subnetworks (alerting, orienting, and executive control) of 90 children with BECTS and 90 healthy children. Read More