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Cancer Cell 2018 Dec;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Read More

Diabetes Obes Metab 2018 Dec 9. Epub 2018 Dec 9.

University Medical Center Groningen and Bethesda Diabetes Research Center, The Netherlands.

Aims: Enrollment criteria vary substantially between the cardiovascular outcome trials (CVOTs) of sodium-glucose cotransporter-2 inhibitors (SGLT-2is), impacting how representative a trial population is to the general type 2 diabetes (T2D) population. The aim was to evaluate the representativeness of four SGLT-2i CVOTs to a general T2D population.

Methods: T2D patients were included from Germany, the Netherlands, Norway, and Sweden. Read More

Scand J Med Sci Sports 2018 Dec 9. Epub 2018 Dec 9.

Utrecht University, University Medical Center Utrecht, Rudolf Magnus Institute of Neurosciences, Department Rehabilitation, Physical Therapy Science & Sports, Utrecht, The Netherlands.

Background: Although the Nordic Hamstring Exercise (NHE) prevents hamstring injury in soccer players effectively, the annual incidence of these injuries still increases. This may be because of poor long-term compliance with the program. Furthermore, the timing and amplitude of gluteal and core muscle activation seem to play an important role in hamstring injury prevention, the NHE program was not designed to improve activation of these muscles. Read More

Nephrol Dial Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Background: Maintenance of kidney function in kidney allografts remains a challenge, as the allograft often progressively develops fibrosis after kidney transplantation. Fibrosis is caused by the accumulation of extracellular matrix proteins like type I and III collagen (COL I and III) that replace the functional tissue. We assessed the concentrations of a neo-epitope fragment of COL III generated by matrix metalloproteinase-9 cleavage (C3M) in two rat models resembling the ischaemic injury taking place following kidney transplantation. Read More

Nat Microbiol 2018 Dec 10. Epub 2018 Dec 10.

Max Planck Institute for Marine Microbiology, Bremen, Germany.

Ammonia-oxidizing archaea of the phylum Thaumarchaeota are among the most abundant marine microorganisms. These organisms thrive in the oceans despite ammonium being present at low nanomolar concentrations. Some Thaumarchaeota isolates have been shown to utilize urea and cyanate as energy and N sources through intracellular conversion to ammonium. Read More

Am J Phys Med Rehabil 2018 Dec 6. Epub 2018 Dec 6.

Member of the Psychosocial Intervention and Functional Rehabilitation Research Group, Department of Biomedical Sciences, Medicine and Physiotherapy, Faculty of Physiotherapy, University of A Coruña, A Coruña Campus, 15071 A Coruña, Spain.

Objective: The aim of this study was to evaluate the effects of an exercise therapy program on pain and physical dimension of health-related quality of life for young adults with musculoskeletal pain.

Design: Randomized controlled single-blind trial. Fifty-seven subjects (58% women) were randomly assigned to experimental (n=28; 21. Read More

J Alzheimers Dis 2018 Dec 1. Epub 2018 Dec 1.

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Background: Cross-sectional studies of quality of life (QOL) of people with young-onset dementia shows diverging results.

Objective: To identify factors associated with QOL in people with young-onset Alzheimer's (AD) and frontotemporal dementia (FTD) and explore development in QOL over a two-year period, including differences between the two subtypes.

Methods: A two-year cohort study of 88 community-dwelling people with young-onset AD and FTD recruited from Nordic memory clinics. Read More

Spine J 2018 Dec 7. Epub 2018 Dec 7.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia.

Background And Context: The lumbar paraspinal muscles, including the erector spinae and multifidus, play an important role in movement and control of the spine. However, our understanding of their contribution to low back pain and disability is unclear. Systematic reviews have reported conflicting evidence for an association between paraspinal muscle size and low back pain, and a paucity of data examining muscle cross-sectional area and low back disability. Read More

Acta Trop 2018 Dec 7. Epub 2018 Dec 7.

Center of Mathematics, Computing, and Cognition, Federal University of ABC, São Bernardo, SP, Brazil.

Arboviral diseases have been considered a global public health problem due to their growing territorial dispersion and impact on the population around the world. Individuals affected by the chikungunya virus go through an acute febrile illness associated with severe pain and long-lasting polyarthralgia. After the initial stage, infected individuals may progress to the chronic stage, which has an epidemic character and a high rate of disability and reduced mobility, impacting negatively on their quality of life. Read More

Cancer Epidemiol 2018 Dec 5;58:89-97. Epub 2018 Dec 5.

Department of Epidemiology, Human Genetics, and Environmental Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Electronic address:

Background: Over the past 20 years, many novel agents and treatment regimens have been developed to treat mantle cell lymphoma (MCL). This study aimed to determine the impact of these new regimens on the survival of MCL patients from 1995 to 2013.

Methods: All newly diagnosed adult MCL patients in the Surveillance, Epidemiology, and End Results (SEER) and Texas Cancer Registry (TCR) databases were included. Read More

Nutr Res 2018 Dec 19;60:13-25. Epub 2018 Aug 19.

Lund University, Skane University Hospital, Department of Internal Medicine, Malmö, Sweden. Electronic address:

Food may induce inflammation and favor development of metabolic diseases, which have been associated with increased inflammation and potential risk of cognitive impairment. It is customary to know whether food or disease promote inflammation. Our hypothesis was that Okinawan-based Nordic (O-BN) diet leads to decreased circulating concentrations of inflammatory and neural biomarkers. Read More

Clin Linguist Phon 2018 Dec 11:1-21. Epub 2018 Dec 11.

a Department of Nordic Studies and Linguistics , University of Copenhagen , Copenhagen , Denmark.

The lexical-grammatical divide has been a widely addressed topic in aphasia. Speech parts are generally classified as either belonging to a lexical or a grammatical category based on the frequency of acquisition of new members in their paradigms (open vs. closed classes), thus neglecting heterogeneity within categories. Read More

Br J Community Nurs 2018 Dec;23(12):597-604

Associate professor, Study director, Aarhus University, Department of Public Health, Denmark.

The pressure on homecare nursing in the Nordic countries has increased in recent years because of a reorganisation of healthcare systems that has put a focus on very early discharge from hospital as well as demographic changes. This article details an analysis of the findings of 13 published qualitative research reports about Nordic homecare nurses' experiences of their work. Using a process of meta-ethnography, the authors identify five themes within the primary research: home care as a professional practice on foreign ground; home care as a massive time constraint; home care as fair rationing; home care as relationships with relatives as fellow players or opponents; and home care as latent paternalism. Read More

Sci Rep 2018 Dec 5;8(1):17651. Epub 2018 Dec 5.

Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.

Phospho flow is a powerful approach to detect cell signaling aberrations, identify biomarkers and assess pharmacodynamics, and can be performed using cryopreserved samples. The effects of cryopreservation on signaling responses and the reproducibility of phospho flow measurements are however unknown in many cell systems. Here, B lymphocytes were isolated from healthy donors and patients with the B cell malignancy chronic lymphocytic leukemia and analyzed by phospho flow using phospho-specific antibodies targeting 20 different protein epitopes. Read More

PLoS One 2018 3;13(12):e0207324. Epub 2018 Dec 3.

Clinical Development, Biogen, Cambridge, Massachusetts, United States of America.

Background: Systemic sclerosis (SSc) is characterized by excessive fibrosis throughout the body. This leads to the release of extracellular matrix (ECM) fragments into circulation, where they may be quantified as biomarkers. The objectives were to investigate levels of ECM turnover biomarkers and the diagnostic power of these. Read More

Transl Oncol 2018 Nov 29;12(2):368-374. Epub 2018 Nov 29.

Nordic Bioscience A/S, Herlev, Denmark.

Objectives: Remodeling of the extracellular matrix (ECM) is a key event in different lung disorders, such as fibrosis and cancer. The most common cell type in the connective tissue is fibroblasts, which transdifferentiate into myofibroblasts upon activation. All myofibroblasts express α-SMA, which has been found to be upregulated in lung fibrosis and cancer. Read More

Int J Dent 2018 1;2018:8572371. Epub 2018 Nov 1.

Nordic Institute of Dental Materials (NIOM), Oslo, Norway.

Dental erosive wear (DEW) is common among children and adolescents, and a survey of Icelandic children showed that 30.7% of 15-year-olds were diagnosed with the condition. To gain knowledge about dental practitioners' experiences, opinions, and treatment decisions. Read More

Cells 2018 Nov 30;7(12). Epub 2018 Nov 30.

Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000 Leuven, Belgium.

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to reduce protein load and restore homeostasis, including via induction of autophagy. We used the proline analogue l-azetidine-2-carboxylic acid (AZC) to induce ER stress, and assessed its effect on autophagy and Ca homeostasis. Treatment with 5 mM AZC did not induce poly adenosine diphosphate ribose polymerase (PARP) cleavage while levels of binding immunoglobulin protein (BiP) and phosphorylated eukaryotic translation initiation factor 2α (eIF2α) increased and those of activating transcription factor 6 (ATF6) decreased, indicating activation of the protein kinase RNA-like ER kinase (PERK) and the ATF6 arms of the UPR but not of apoptosis. Read More

Otolaryngol Head Neck Surg 2018 Dec 4:194599818815683. Epub 2018 Dec 4.

1 Otolaryngology Head and Neck Surgery, Tripler Army Medical Center, Hawaii, USA.

Objective: To systematically review the literature on anti-inflammatory medications for treating pediatric obstructive sleep apnea and perform meta-analysis of the available data.

Data Sources: PubMed/MEDLINE and 4 additional databases.

Review Methods: Three authors independently and systematically searched through June 28, 2018, for studies that assessed anti-inflammatory therapy for treatment of pediatric obstructive sleep apnea (OSA). Read More

Eur J Vasc Endovasc Surg 2018 Nov 30. Epub 2018 Nov 30.

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.

Eur J Vasc Endovasc Surg 2018 Nov 30. Epub 2018 Nov 30.

SingVaSC, Singapore Vascular Surgical Collaborative, Singapore; Cardiovascular Research Institute, National University of Singapore, Singapore; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Vascular Surgery, National University Heart Centre, Singapore. Electronic address:

Dent Mater 2018 Nov 26. Epub 2018 Nov 26.

Nordic Institute of Dental Materials, Sognsveien 70 A, NO-0855 Oslo, Norway. Electronic address:

Objectives: Cellular responses including cell death are induced by in vitro exposure to the un-polymerized dental monomer 2-hydroxyethyl methacrylate (HEMA). Activation of the Nrf2/ARE signaling pathway has been suggested to mediate the cellular responses. Activation of this pathway may occur either indirectly through generation of increased oxidative stress or through direct binding to cysteine thiols due to the electrophilic properties of HEMA. Read More

BMC Musculoskelet Disord 2018 Nov 29;19(1):418. Epub 2018 Nov 29.

Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.

Background: Clinical guidelines recommend that people with back pain be given information and education about their back pain, advice to remain active and at work, and exercises to improve mobility and physical activity. Guidelines, however, rarely describe how this is best delivered. The aim of this paper is to present the development, theories, and underlying evidence for 'GLA:D Back' - a group education and exercise program that translates guideline recommendations into a clinician-delivered program for the promotion of self-management in people with persistent/recurrent back pain. Read More

PLoS One 2018 27;13(11):e0208070. Epub 2018 Nov 27.

Department of Health and Sports Sciences, School of Health Sciences, Asahi University, 1851 Hozumi, Mizuho, Gifu, Japan.

Nordic walking (NW) is a total body version of walking increasingly used as a health-promoting activity by middle-aged and older adults. The present study examined the relationship between force exerted through the pole and physiological response during NW. In this non-randomized exercise trial, 17 participants comprising 8 middle-aged and older recreationally trained Nordic walkers (NWrec: 63. Read More

Spine (Phila Pa 1976) 2018 Nov 20. Epub 2018 Nov 20.

Nordic Institute of Chiropractic and Clinical Biomechanics, Denmark.

Study Design: This cohort study was an analysis of prospectively collected data in the DaneSpine Database.

Objective: The objective was to determine whether pre-operative magnetic resonance imaging (MRI) findings were associated with the frequency of surgical revision due to recurrent lumbar disc herniation (LDH) within three years after first-time, single-level, simple lumbar discectomy.

Summary Of Background Data: Because of a risk of poorer outcome in patients receiving revision surgery compared to first-time discectomy, there is a need to identify patients with LDH in risk of surgical revision prior to the primary discectomy. Read More

Eur J Neurosci 2018 Nov 25. Epub 2018 Nov 25.

Department of Biomedicine, Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, & AU IDEAS center NEURODIN, Aarhus University, Aarhus C, Denmark.

The neuropathological hallmarks of Parkinson's disease (PD) are the degeneration and death of dopamine-producing neurons in the ventral midbrain, the widespread intraneuronal aggregation of alpha-synuclein (α) in Lewy bodies and neurites, neuroinflammation, and gliosis. Signs of microglia activation in the PD brain postmortem as well as during disease development revealed by neuroimaging, implicate immune responses in the pathophysiology of the disease. Intensive research during the last two decades has advanced our understanding of the role of these responses in the disease process, yet many questions remain unanswered. Read More

Am J Hematol 2018 Nov 25. Epub 2018 Nov 25.

First Medical Dept., Charles University General Hospital in Prague.

Recently, survival benefit of rituximab maintenance (RM) was confirmed in patients with mantle cell lymphoma (MCL) treated with R-DHAP and autologous stem cell transplant (ASCT). Whether RM improves outcomes in patients treated with other induction regimens is unknown. As part of the NiHiL observational study in patients with malignant lymphomas (GovTrial No. Read More

J Lifestyle Med 2018 Jul 31;8(2):72-78. Epub 2018 Jul 31.

Department of Nursing, Abadeh Branch, Islamic Azad University, Abadeh, Iran.

Background: Work-related musculoskeletal disorders are a significant concern for public health, leading to temporary and permanent disability. Health care workers, including nurses, are at high risk for these disorders. This study aimed to assess the health-promoting lifestyles of nurses and their association with musculoskeletal disorders and symptoms. Read More

Eur J Haematol 2018 Nov 25. Epub 2018 Nov 25.

Hematology section, Specialist medicine, NU Hospital Group, Sweden.

Objectives: The study investigates the hypothesis that inflammation in myelofibrosis (MF) like in myeloma and lymphoma, may disturb iron distribution and contribute to anaemia.

Methods: A cross-sectional study of 80 MF and 23 ET patients was performed.

Results: Thirtyfive % of anaemic MF patients had functional iron deficiency (FID) with transferrin saturation <20 and normal or elevated S-ferritin (<500 μg/L). Read More

Blood Cancer J 2018 Nov 23;8(12):123. Epub 2018 Nov 23.

service d'Hematologie, CHU de Nantes, Nantes, France.

Purpose: multiple myeloma is considered an incurable hematologic cancer but a subset of patients can achieve long-term remissions and survival. The present study examines the clinical features of long-term survival as it correlates to depth of disease response.

Patients & Methods: this was a multi-institutional, international, retrospective analysis of high-dose melphalan-autologous stem cell transplant (HDM-ASCT) eligible MM patients included in clinical trials. Read More

J Cancer Res Clin Oncol 2018 Nov 22. Epub 2018 Nov 22.

Biomarkers & Research, Nordic Bioscience, Herlev Hovedgade 205-207, 2730, Herlev, Denmark.

Purpose: Elastin is a signature protein of lungs. Increased elastin turnover driven by altered proteolytic activity is an important part of lung tumorigenesis. Elastin-derived fragments have been shown to be pro-tumorigenic, however, little is known regarding the biomarker potential of such elastin fragments. Read More

Sci Rep 2018 Nov 22;8(1):17232. Epub 2018 Nov 22.

Water Resources and Environmental Engineering Research Unit, PO Box 4300, 90014 University of Oulu, Oulu, Finland.

Quantifying short-term changes in river flow is important in understanding the environmental impacts of hydropower generation. Energy markets can change rapidly and energy demand fluctuates at sub-daily scales, which may cause corresponding changes in regulated river flow (hydropeaking). Due to increasing use of renewable energy, in future hydropower will play a greater role as a load balancing power source. Read More

Osteoarthritis Cartilage 2018 Nov 19. Epub 2018 Nov 19.

Nordic Bioscience A/S, Herlev Hovedgade 207, DK-2730 Herlev, Denmark.

In 1992, the Food and Drug Administration (FDA) instituted the accelerated approval regulations that allow drugs or biologics for serious conditions that fill an unmet medical need to be approved on the basis of a surrogate endpoint or an intermediate clinical endpoint. The current definition of a serious condition includes chronic disabling conditions, such as osteoarthritis (OA), and thereby provides expanded opportunities for the use of biomarkers for regulatory approval of drugs for OA. The use of surrogates or intermediate clinical endpoints for initial regulatory approval of a drug or biologic requires confirmation in a post-marketing study of a drug effect on a clinically relevant outcome, such as on how a patient feels, functions or survives. Read More

J Mol Cell Cardiol 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Background: Extracellular matrix metabolism and cardiac cell death participate centrally in myocardial infarction (MI). This study tested the roles of collagenolytic cathepsin K (CatK) in post-MI left ventricular remodeling.

Methods And Results: Patients with acute MI had higher plasma CatK levels (20. Read More

Eur J Pediatr 2018 Nov 21. Epub 2018 Nov 21.

Department of Sports Science and Clinical Biomechanics, Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark.

Spinal pain, back pain, and/or neck pain begins early in life and is strongly associated with spinal pain in adulthood. Understanding the relationship between psychological and social factors and adolescent spinal pain may be important in both the prevention and treatment of spinal pain in this age group. We aimed to determine if psychological and social factors were associated with spinal pain in a cross-sectional study of a school-based cohort of 1279 Danish adolescents aged 11-13, who were categorized into "any" and "substantial" spinal pain. Read More

Res Rep Urol 2018 25;10:181-187. Epub 2018 Oct 25.

Department of Urology, Haukeland University Hospital.

Purpose: To examine the variation in venous thromboembolism prophylactic treatment (VTEP) among renal cancer patients undergoing surgery.

Materials And Methods: An Internet-based questionnaire on renal tumor management before and after surgery was mailed to all Nordic departments of urology. The questions focused on the use of VTEP and were subdivided into different surgical modalities. Read More

Nutrients 2018 Nov 20;10(11). Epub 2018 Nov 20.

Diet, Genes and Environment, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark.

The aim of the present study was to describe vitamin D status and seasonal variation in the general Danish population. In this study, 3092 persons aged 2 to 69 years (2565 adults, 527 children) had blood drawn twice (spring and autumn) between 2012 and 2014. A sub-sample of participants had blood samples taken monthly over a year. Read More

Curr Opin Rheumatol 2019 Jan;31(1):80-89

The D-BOARD FP7 Consortium.

Purpose Of Review: This review focuses on the molecular taxonomy of osteoarthritis from the perspective of molecular biomarkers. We discuss how wet biochemical markers may be used to understand disease pathogenesis and progression and define molecular endotypes of osteoarthritis and how these correspond to clinical phenotypes.

Recent Findings: Emerging evidence suggests that osteoarthritis is a heterogeneous and multifaceted disease with multiple causes, molecular endotypes and corresponding clinical phenotypes. Read More

J Clin Nurs 2018 Nov 21. Epub 2018 Nov 21.

Department of Gynecology and Obstetrics, Aarhus University Hospital, Palle Juul-Jensens, Boulevard 99, 8200, Aarhus N, Denmark.

Aim And Objectives: To review the literature on Nordic women's lived experiences and quality of life (QoL) after gynaecological cancer treatment.

Background: While incidence and survival are increasing in all groups of gynaecological cancers in the Nordic countries, inpatient hospitalization has become shorter in relation to treatment. This has increased the need for follow-up and rehabilitation. Read More

Scand Cardiovasc J 2018 Nov 20:1-26. Epub 2018 Nov 20.

d Heart and Vascular Theme Karolinska University Hospital , Stockholm , Sweden.

Objectives: Guidelines of the European Society of Cardiology (ESC) recommend that ferritin and transferrin saturation should be tested in chronic heart failure (HF) and state that iron treatment with ferric carboxymaltose should be considered in HF patients with iron deficiency to alleviate symptoms and improve exercise tolerance and quality of life. This study evaluates the cost effectiveness of the implementation of this recommendation in four Nordic countries (Denmark, Finland, Norway, and Sweden).

Design: We performed a cost-utility analysis comparing ferric carboxymaltose treatment with placebo over a one-year time period in each country. Read More

Biomarkers 2018 Nov 20:1-28. Epub 2018 Nov 20.

b Clinical Development , Biogen , Cambridge , MA.

Purpose: Extracellular matrix (ECM) deposition and remodelling in skin and lungs of systemic sclerosis (SSc) subjects lead to release of metabolites/biomarkers into circulation. We investigated if biomarkers of ECM degradation (biglycan and elastin) and macrophage activation (citrullinated vimentin) could identify diffuse SSc (dSSc) subjects from controls and the biomarkers discriminative power.

Methods: DSSc subjects (n = 40) fulfilling the 2013 EULAR/ACR classification criteria were divided in early (<2years of symptoms) and late (≥10years of symptoms). Read More

Trends Neurosci 2018 Nov 16. Epub 2018 Nov 16.

Donders Institute for Brain, Cognition, and Behaviour, Radboud University and Radboudumc, Nijmegen, The Netherlands. Electronic address:

Adaptation to the ever-changing world is critical for survival, and our brains are particularly tuned to remember events that differ from previous experiences. Novel experiences induce dopamine release in the hippocampus, a process which promotes memory persistence. While axons from the ventral tegmental area (VTA) were generally thought to be the exclusive source of hippocampal dopamine, recent studies have demonstrated that noradrenergic neurons in the locus coeruleus (LC) corelease noradrenaline and dopamine in the hippocampus and that their dopamine release boosts memory retention as well. Read More

Br J Haematol 2018 Nov 18. Epub 2018 Nov 18.

Child and Adolescent Health, Aarhus University Hospital, Aarhus, Denmark.

Asparaginase is essential in childhood acute lymphoblastic leukaemia (ALL) treatment, however hypersensitivity reactions to pegylated asparaginase (PEG-asparaginase) hampers anti-neoplastic efficacy. Patients with PEG-asparaginase hypersensitivity have been shown to possess zero asparaginase enzyme activity. Using this measurement to define the phenotype, we investigated genetic predisposition to PEG-asparaginase hypersensitivity in a genome-wide association study (GWAS). Read More

Scand J Gastroenterol 2018 Nov 19:1-10. Epub 2018 Nov 19.

e Department of Surgery , Sahlgrenska University Hospital , Gothenburg , Sweden.

Objectives: To quantify healthcare resource use (HRU) and costs in relation to carcinoid syndrome (CS) and carcinoid heart disease (CHD) in a real-world setting, and to provide perspective on treatment patterns.

Materials And Methods: Patient data and HRU were collected retrospectively from three Swedish healthcare registers. Adult patients diagnosed with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) grade 1 or 2 and CS who purchased somatostatin analogs (SSAs), and experienced controlled (defined by SSAs use) and uncontrolled (defined by SSAs dose escalation) CS for ≥8 months during the study period were included. Read More

Med Sci Sports Exerc 2018 Dec;50(12):2614

Department of Health Sciences and Kinesiology Georgia Southern University Statesboro, GA College of Physical Education Ningbo University Ningbo, Zhejiang, PEOPLE'S REPUBLIC OF CHINA.

Acta Neurol Scand 2018 Nov 14. Epub 2018 Nov 14.

Department of Neurology, Shaanxi Provincial People's Hospital, Third Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.

Objectives: Migraine ranks among the most frequent neurological disorders globally. Co-enzyme Q10 (CoQ10) is a nutritional agent that might play a preventative role in migraine. This meta-analysis aimed to investigate the effects of CoQ10 as a supplemental agent in migraine. Read More

Environ Monit Assess 2018 Nov 13;190(12):719. Epub 2018 Nov 13.

Department of Civil, Environmental and Natural Resources Engineering, Division of Geosciences and Environmental Engineering, Luleå University of Technology, 97187, Luleå, Sweden.

Acid rock drainage (ARD) is a major problem related to the management of mining wastes, especially concerning deposits containing sulphide minerals. Commonly used tests for ARD prediction include acid-base accounting (ABA) tests and the net acid generation (NAG) test. Since drainage quality largely depends on the ratio and quality of acid-producing and neutralising minerals, mineralogical calculations could also be used for ARD prediction. Read More

J Perinatol 2018 Nov 13. Epub 2018 Nov 13.

Department of Neonatology, Tampere University Hospital, Tampere, Finland.

Objective: To evaluate trends and perinatal outcomes of planned home deliveries in Finland.

Study Design: All infants born in 1996-2013, excluding those born preterm, by operative delivery, and without information on birth mode or gestational age, were studied. The study group included 170 infants born at home as planned, 720,047 infants born at hospital were controls. Read More

Euro Surveill 2018 Nov;23(45)

Karolinska Institutet, Stockholm, Sweden.

IntroductionAntimicrobial resistance is increasing rapidly in countries with low hygiene levels and poorly controlled antimicrobial use. The spread of resistant bacteria poses a threat to healthcare worldwide. Refugees and migrants from high-prevalence countries may add to a rise in multidrug-resistant (MDR) bacteria in low-prevalence countries. Read More

Brain 2018 Dec;141(12):3308-3318

MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.

Hypokalaemic periodic paralysis is a rare genetic neuromuscular disease characterized by episodes of skeletal muscle paralysis associated with low serum potassium. Muscle fibre inexcitability during attacks of paralysis is due to an aberrant depolarizing leak current through mutant voltage sensing domains of either the sarcolemmal voltage-gated calcium or sodium channel. We report a child with hypokalaemic periodic paralysis and CNS involvement, including seizures, but without mutations in the known periodic paralysis genes. Read More