8,989 results match your criteria Noninvasive Ventilation

Predictors of Mortality in Tocilizumab-Treated Severe COVID-19.

Vaccines (Basel) 2022 Jun 20;10(6). Epub 2022 Jun 20.

Pulmonary Department, Corfu General Hospital, 49100 Corfu, Greece.

Purpose: Tocilizumab is associated with positive outcomes in severe COVID-19. We wanted to describe the characteristics of nonresponders to treatment.

Methods: This was a retrospective multicenter study in two respiratory departments investigating adverse outcomes at 90 days from diagnosis in subjects treated with tocilizumab (8 mg/kg intravenously single dose) for severe progressive COVID-19. Read More

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Predictors of Noninvasive Respiratory Support Failure in COVID-19 Patients: A Prospective Observational Study.

Medicina (Kaunas) 2022 Jun 6;58(6). Epub 2022 Jun 6.

Clinic of Chest Diseases, Immunology and Allergology, Institute of Clinical Medicine, Vilnius University, M.K. Ciurlionio 21, 03101 Vilnius, Lithuania.

Respiratory assistance tactic that is best for COVID-19-associated acute hypoxemic respiratory failure (AHRF) individuals has yet to be determined. Patients with AHRF may benefit from the use of a high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV). The goals of this prospective observational research were to estimate predictive factors for HFNC and NIV failure in COVID-19-related AHRF subjects. Read More

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Development of a Medium Care Unit Using an Inexperienced Respiratory Staff: Lessons Learned during the COVID-19 Pandemic.

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

Department of Pneumology, Erasme University Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.

The different waves of the COVID-19 pandemic caused dramatic issues regarding the organization of care. In this context innovative solutions have to be developed in a timely manner to adapt to the organization of the care. The establishment of middle care (MC) units is a bright example of such an adaptation. Read More

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Impact of establishing a respiratory high dependency unit for SCAP patients on the therapeutic effect, prognosis, and expenditure: a retrospective case-control study.

Qin Yalan Tong Jin

Sci Rep 2022 Jun 23;12(1):10703. Epub 2022 Jun 23.

Department of Respiratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, 76# Linjiang Road, Yuzhong district, Chongqing, 400010, China.

To explore the effects of establishing a high dependency unit (HDU) on the prognosis, outcome, and expenditure of patients with severe community-acquired pneumonia (SCAP). 108 SCAP patients were recruited from the respiratory intensive care unit (RICU) of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Of these, 87 qualified the study-selection criteria and were divided into HDU group (treated in HDU after discharge from RICU prior to transfer to normal unit) (n = 40) and normal group (not treated in the HDU) (n = 47). Read More

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Electric Cell-Substrate Impedance Sensing (ECIS) as a Platform for Evaluating Barrier-Function Susceptibility and Damage from Pulmonary Atelectrauma.

Biosensors (Basel) 2022 Jun 5;12(6). Epub 2022 Jun 5.

Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA.

Biophysical insults that either reduce barrier function (COVID-19, smoke inhalation, aspiration, and inflammation) or increase mechanical stress (surfactant dysfunction) make the lung more susceptible to atelectrauma. We investigate the susceptibility and time-dependent disruption of barrier function associated with pulmonary atelectrauma of epithelial cells that occurs in acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI). This in vitro study was performed using Electric Cell-substrate Impedance Sensing (ECIS) as a noninvasive evaluating technique for repetitive stress stimulus/response on monolayers of the human lung epithelial cell line NCI-H441. Read More

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Deep sedation with propofol in patients undergoing left atrial ablation procedures-Is it safe?

Heart Rhythm O2 2022 Jun 22;3(3):288-294. Epub 2022 Feb 22.

Department of Electrophysiology, German Heart Center Munich, Technische Universitaet Munich, Munich, Germany.

Background: Catheter ablation for atrial fibrillation (AF) or left atrial tachycardia is well established. To avoid body movement and pain, sedative and analgesic agents are used.

Objective: The aim was to investigate safety of sedation/anti-pain protocol administered by electrophysiology (EP) staff. Read More

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Association of Illness Severity With Family Outcomes Following Pediatric Septic Shock.

Crit Care Explor 2022 Jun 15;4(6):e0716. Epub 2022 Jun 15.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington, Seattle, WA.

It is unknown which families are at risk for poor outcomes following a child's critical illness.

Objectives: To evaluate if pediatric septic shock severity is associated with caregiver distress and family dysfunction throughout the year postadmission and if caregiver outcomes are associated with child health-related quality of life (HRQL).

Design Setting And Participants: Secondary analysis of the Life After Pediatric Sepsis Evaluation prospective cohort study among children less than 18 years old with community-acquired septic shock requiring vasoactive-inotropic support and invasive or noninvasive ventilation in 12 academic U. Read More

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Quantification of respiratory sounds by a continuous monitoring system can be used to predict complications after extubation: a pilot study.

J Clin Monit Comput 2022 Jun 22. Epub 2022 Jun 22.

Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

To show that quantification of abnormal respiratory sounds by our developed device is useful for predicting respiratory failure and airway problems after extubation. A respiratory sound monitoring system was used to collect respiratory sounds in patients undergoing extubation. The recorded respiratory sounds were subsequently analyzed. Read More

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High-pressure NIV for acute hypercapnic respiratory failure in COPD: improved survival in a retrospective cohort study.

BMJ Open Respir Res 2022 06;9(1)

Respiratory Medicine Unit, Department of Internal Medicine, Herlev-Gentofte Hospital, Copenhagen University Hospital, Hellerup, Denmark.

Introduction: Updated treatment guidelines for acute hypercapnic respiratory failure (AHRF) in chronic obstructive pulmonary disease (COPD) with non-invasive ventilation (NIV) in 2016 recommended a rapid increase in inspiratory positive airway pressure (IPAP) to 20 cm HO with possible further increase for patients not responding. Previous guidelines from 2006 suggested a more conservative algorithm and maximum IPAP of 20 cm HO.

Aim: To determine whether updated guidelines recommending higher IPAP during NIV were related with improved outcome in patients with COPD admitted with AHRF, compared with NIV with lower IPAP. Read More

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Automatic Tube Compensation During Spontaneous Breathing Trial.

Respir Care 2022 Jun 21. Epub 2022 Jun 21.

Médecine Intensive-Réanimation, Hôpital Edouard-Herriot, Lyon, France; Université de Lyon, Lyon, France; and Institut Mondor de Recherches Biomédicales INSERM 955 CNRS 7240, Créteil, France.

Background: Automatic tube compensation (ATC) is an option available in any ICU ventilator that compensates for the resistive pressure drop due to the endotracheal tube by providing flow assistance. The goal of the present study was to compare ATC to other patient triggered modes of support in terms of spontaneous breathing trial (SBT) and extubation success.

Methods: Two authors (JB and PCF), independently and blinded to each other, searched through PubMed, Web of Science, and Cochrane from inception-May 26, 2021, with the following search terms entered as MeSH terms in all fields: "Automatic Tube Compensation. Read More

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Abandon Noninvasive Ventilation in Bronchiolitis? How Unrecognized Bias Can Lead to Problematic Conclusions.

Crit Care Med 2022 Jul 13;50(7):e653-e654e. Epub 2022 Jun 13.

Department of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.

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Clinical characteristics and outcomes of the first two waves of the COVID-19 pandemic in a community hospital: a retrospective cohort study.

IJID Reg 2022 Jun 6;3:1-7. Epub 2022 Feb 6.

Department of Internal Medicine, AMITA Health Saint Francis Hospital, Evanston, IL.

Objective: To describe the clinical characteristics and outcomes of two waves of the COVID-19 pandemic.

Methods: A de-identified dataset of patients with COVID-19 admitted to our community hospital in Evanston, Illinois, from March 1, 2020 to February 28, 2021 was retrospectively reviewed. Patients from the first wave were identified as those admitted during the initial peak of admissions observed at our hospital between March 1, 2020 and September 3, 2020. Read More

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Noninvasive Positive Pressure Ventilation (NIPPV)-Associated Expanding Hiatal Hernia Causing Pulmonary Tamponade: A Case Report on Unusual Complication of NIPPV.

Cureus 2022 May 17;14(5):e25069. Epub 2022 May 17.

Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, USA.

Numerous diseases related to gastric distension have been found and shown to be linked with noninvasive positive pressure ventilation (NIPPV). We describe the case of a 93-year-old female who came with progressively worsening shortness of breath that initially responded to NIPPV but subsequently deteriorated. Imaging revealed gaseous distension of a preexisting hiatal hernia with air-fluid levels and compressive effects on the left lower lobe of the lung. Read More

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Clinical Profile of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection Developing Pulmonary Barotrauma on Mechanical Ventilation.

Indian J Crit Care Med 2022 May;26(5):613-618

Sir HN Medical Research Society, Sir HN Reliance Foundation Hospital and Research Centre, Mumbai, Maharashtra, India.

Background: There is limited information on clinical profile and outcomes of patients on mechanical ventilation (MV) who developed pulmonary barotrauma (PBT) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Patients And Methods: In a retrospective observational study, all SARS-CoV-2 pneumonia patients admitted from March 28, 2020, to August 31, 2020, at Sir HN Reliance Foundation Hospital and Research Center and Seven Hills Hospital (Reliance Facility), Mumbai, India, of 18 years and above on MV and developed PBT, were included.

Results: A total of 14 SARS-CoV-2 patients of 45 on MV (31. Read More

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Observational, prospective, single-center study: Should body mass index be added to the scoring criteria of hepatic critically ill patients in the intensive care unit.

Am J Med Sci 2022 Jun 16. Epub 2022 Jun 16.

ICU department at the National Heart Institute, Cairo, Egypt.

Background: Obesity has recently become more prevalent, and thus the coexistence of liver cirrhosis with obesity has become very pervasive. The purpose of this study is to investigate the correlation between abnormal body mass index (BMI) (overweight and obese) and clinical outcomes in critically ill cirrhotic patients.

Methods: This is a single-center, prospective observational study of cirrhotic patients admitted to the intensive care unit for either medical or surgical indications in the period from February 2018 to December 2020. Read More

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Can We Satisfy Family in Intensive Care Unit? A Tunisian Experience.

Indian J Crit Care Med 2022 Feb;26(2):185-191

University of Tunis El Manar, University of Medicine of Tunis, Ben Arous Regional Hospital, Tunis, Tunisia.

Background: Communication improvement and family satisfaction in intensive care unit (ICU) are the main indicators of care quality. Our study aims were to evaluate family satisfaction in our intensive care and identify factors influencing the satisfaction level.

Materials And Methods: We performed a descriptive prospective study in the ICU of Ben Arous régional hospital conducted between October 2016 and June 2018. Read More

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February 2022

A Dangerous Duo: Spontaneous Pneumomediastinum and Venous Thromboembolism at Presentation in a Patient with COVID-19 Pneumonia.

J Community Hosp Intern Med Perspect 2022 31;12(1):13-18. Epub 2022 Jan 31.

Department of Medicine, Luminis Health Anne Arundel Medical Center, Annapolis, MD, USA.

Background: Coronavirus disease 2019 (Covid-19) is associated with spontaneous pneumomediastinum (SPM) predominantly in those after positive pressure ventilation (PPV) support. Additionally, many cases of venous thromboembolism (VTE) in COVID-19 patients were described. Our case is the first to describe SPM and VTE present on admission in a patient with Covid -19 pneumonia. Read More

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January 2022

Delirium incidence and risk factors in patients undergoing non-invasive ventilation for acute respiratory failure: a multicenter observational trial.

Minerva Anestesiol 2022 Jun 15. Epub 2022 Jun 15.

Unit of Respiratory Diseases, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena-Reggio Emilia, Modena, Italy.

Background: Noninvasive ventilation (NIV) still has high failure rate when used for de novo acute respiratory failure (ARF). Delirium may impact the outcome, however data regarding its incidence, timing of occurrence and clinical predictors in this subset of patients are scarce.

Methods: Consecutive patients with de novo ARF subjected to NIV were recruited in 10 Italian Respiratory Intensive Care Units (RICUs) and Intensive Care Units (ICUs). Read More

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A retrospective analysis of the effects of TIME on Compliance and Driving pressures in acute respiratory distress syndrome: The TIMED study.

Respir Care 2022 Jun 15. Epub 2022 Jun 15.

Creighton University School of Pharmacy and Health Professions, Omaha, NE, USA.

Background: The evolution of compliance and driving pressure in acute respiratory distress syndrome (ARDS) and the effects of time spent on noninvasive respiratory support prior to intubation has not been well studied. We conducted this study to assess the effect of the duration of noninvasive respiratory support prior to intubation (i.e. Read More

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Comparison of Local and Systemic Inflammation During Invasive Versus Noninvasive Ventilation in Rats.

J Interferon Cytokine Res 2022 Jun 15. Epub 2022 Jun 15.

Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, USA.

The impact of noninvasive ventilation (NIV) on local and systemic inflammation is poorly characterized, particularly when compared with invasive mechanical ventilation (IMV). We sought to quantify the local and systemic inflammatory response of these 2 respiratory treatments in rats with lipopolysaccharide (LPS)-induced lung injury (LPS-injured) and healthy rats. Animals were subjected to 4 h of NIV or IMV treatments at noninjurious settings, or 4 h of control treatment in which healthy or LPS-injured animals remained spontaneously breathing under isoflurane anesthesia with no respiratory support. Read More

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Ipratropium bromide and noninvasive ventilation treatment for COPD.

Am J Transl Res 2022 15;14(5):3319-3326. Epub 2022 May 15.

Department of Respiratory and Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University Fuzhou 350001, Fujian Provincial, China.

Objective: To explore the effects of ipratropium bromide combined with non-invasive ventilation for patients with both chronic obstructive pulmonary disease (COPD) and respiratory failure.

Methods: A total of 110 patients with both COPD and respiratory failure who were admitted to our hospital from April 2018 to August 2019 were enrolled in this study; of which 52 patients were treated with a noninvasive ventilator as Group A, and the rest were treated with ipratropium bromide combined with noninvasive ventilation as Group B. The two groups were compared for blood gas indexes, pulmonary function, and treatment efficacy, and adverse reactions. Read More

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Continuous noninvasive blood gas estimation in critically ill pediatric patients with respiratory failure.

Sci Rep 2022 Jun 14;12(1):9853. Epub 2022 Jun 14.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Patients supported by mechanical ventilation require frequent invasive blood gas samples to monitor and adjust the level of support. We developed a transparent and novel blood gas estimation model to provide continuous monitoring of blood pH and arterial CO in between gaps of blood draws, using only readily available noninvasive data sources in ventilated patients. The model was trained on a derivation dataset (1,883 patients, 12,344 samples) from a tertiary pediatric intensive care center, and tested on a validation dataset (286 patients, 4030 samples) from the same center obtained at a later time. Read More

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Clinical Outcomes of Acute Respiratory Failure Associated With Noninvasive and Invasive Ventilation in a Pediatric ICU.

Respir Care 2022 Jun 14. Epub 2022 Jun 14.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, C.S. Mott Children's Hospital, Ann Arbor, Michigan.

Background: It remains unknown if pediatric patients failing initial noninvasive ventilation (NIV) experience worse clinical outcomes than those successfully treated with NIV or those primarily intubated.

Methods: This was a single-center, retrospective review of patients admitted with acute respiratory failure to the University of Michigan pediatric intensive care or cardiothoracic ICUs and receiving NIV or invasive mechanical ventilation as first-line therapy.

Results: One hundred seventy subjects met inclusion criteria and were enrolled: 65 NIV success, 55 NIV failure, and 50 invasive mechanical ventilation alone. Read More

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Prediction of high-flow nasal cannula outcomes at the early phase using the modified respiratory rate oxygenation index.

BMC Pulm Med 2022 Jun 13;22(1):227. Epub 2022 Jun 13.

Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.

Background: This study was designed to explore the early predictive value of the respiratory rate oxygenation (ROX) index modified by PaO (mROX) in high-flow nasal cannula (HFNC) therapy in patients with acute hypoxemia respiratory failure (AHRF).

Method: Seventy-five patients with AHRF treated with HFNC were retrospectively reviewed. Respiratory parameters at baseline and 2 h after HFNC initiation were analyzed. Read More

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The impact of continuous positive airway pressure on cardiac mechanics: Findings from a meta-analysis of echocardiographic studies.

J Clin Hypertens (Greenwich) 2022 Jun 13. Epub 2022 Jun 13.

Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.

Current evidence on the effects of continuous positive airway pressure (CPAP) on cardiac mechanics in patients with obstructive sleep apnea (OSA) is based on a few single studies. The authors investigated this topic through a meta-analysis of speckle tracking echocardiography (STE) studies that provided data on left ventricular (LV) and right ventricular (RV) mechanics as assessed by global longitudinal strain (GLS). The PubMed, OVID-MEDLINE, and Cochrane library databases were systematically analyzed to search English-language review papers published from inception to January 31, 2022. Read More

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Non-Invasive Ventilation in the Prehospital Emergency Setting: A Systematic Review and Meta-Analysis.

Prehosp Emerg Care 2022 Jun 22:1-9. Epub 2022 Jun 22.

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Introduction: Noninvasive ventilation is a well-established treatment for acute respiratory failure, being increasingly applied in the prehospital setting. This systematic review and meta-analysis aims to investigate whether early prehospital initiation of noninvasive ventilation reduces mortality compared to standard oxygen therapy.

Methods: We searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from inception to February 7, 2022, for studies comparing prehospital noninvasive ventilation performed by emergency medical services versus standard oxygen therapy in patients with acute respiratory failure. Read More

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Novel autosomal dominant TPM3 mutation causes a combined congenital fibre type disproportion-cap disease histological pattern.

Neuromuscul Disord 2022 May 28. Epub 2022 May 28.

Unité Morphologie Neuromusculaire, Institut de Myologie, GHU Pitié-Salpêtrière, Paris, France.

Tropomyosin 3 (TPM3) gene mutations associate with autosomal dominant and recessive nemaline myopathy 1 (NEM1), congenital fiber type disproportion myopathy (CFTD) and cap myopathy (CAPM1), and a combination of caps and nemaline bodies. We report on a 47-year-old man with polyglobulia, restricted vital capacity and mild apnea hypopnea syndrome, requiring noninvasive ventilation. Physical assessment revealed bilateral ptosis and facial paresis, with high arched palate and retrognathia; global hypotonia and diffuse axial weakness, including neck and upper and lower limb girdle and foot dorsiflexion weakness. Read More

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Fibrinogen, a Promising Marker to Evaluate Severity and Prognosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Observational Study.

Int J Chron Obstruct Pulmon Dis 2022 3;17:1299-1310. Epub 2022 Jun 3.

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China.

Background: Fibrinogen is increasingly being studied as an inflammatory biomarker in chronic obstructive pulmonary disease (COPD), but there are limited data on the role of fibrinogen in assessing the severity of acute exacerbation of COPD (AECOPD). This study aimed to explore whether circulating fibrinogen could be used as a surrogate to measure the severity and predict the prognosis of AECOPD.

Methods: A total of 535 AECOPD patients diagnosed at our center from January 2016 to June 2021 were retrospectively enrolled in this study. Read More

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Risk factors for prolonged mechanical ventilation in neonates following gastrointestinal surgery.

Transl Pediatr 2022 May;11(5):617-624

Division of Neonatology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Prolonged mechanical ventilation (MV) should be avoided in neonates. Noninvasive ventilation (NIV) can facilitate weaning from MV but has risks for patients immediately following foregut surgery due to the potential risk of anastomotic leak. We evaluated the risk factors for prolonged MV following intestinal surgery in neonates. Read More

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