5,995 results match your criteria Noninvasive Ventilation


Outcome Of Use Of Nasal Continuous Positive Airway Pressure Through Infant Flow Drivers In Neonates With Respiratory Distress In A Tertiary Care Hospital In Pakistan.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(4):511-555

Iqbal Memorial Teaching Hospital/Khawaja Muhammad Safdar Medical College Sialkot, Pakistan.

Background: Nasal continuous positive pressure has been used for management of respiratory distress in neonates in various conditions as a primary modality. Objective of the study is to evaluate the frequency of improved outcome and complications of use of nasal CPAP through infant flow drivers in neonates with respiratory distress. The study was conducted from 2nd April 2017 to 2nd October 2017 in neonatal intensive care unit of Allama Iqbal Memorial Teaching Hospital Sialkot. Read More

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January 2019
1 Read

Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD.

Physiol Rep 2019 Jan;7(1):e13955

CIUSSS de l'Ouest-de-l'Île-de-Montréal, Montreal Chest Institute, Meakins-Christie Laboratories, Oscillometry Unit and Centre for Innovative Medicine, McGill University Health Centre and Research Institute, Montreal, Quebec, Canada.

Developed over six decades ago, pulmonary oscillometry has re-emerged as a noninvasive and effort-independent method for evaluating respiratory-system impedance in patients with obstructive lung disease. Here, we evaluated the relationships between hyperpolarized He ventilation-defect-percent (VDP) and respiratory-system resistance, reactance and reactance area (A ) measurements in 175 participants including 42 never-smokers without respiratory disease, 56 ex-smokers with chronic-obstructive-pulmonary-disease (COPD), 28 ex-smokers without COPD and 49 asthmatic never-smokers. COPD participants were dichotomized based on x-ray computed-tomography (CT) evidence of emphysema (relative-area CT-density-histogram ≤ 950HU (RA ) ≥ 6. Read More

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http://dx.doi.org/10.14814/phy2.13955DOI Listing
January 2019

Low Levels of PaO after Long-term Noninvasive Ventilation are a Poor Prognostic Factor in Patients with Restrictive Thoracic Disease.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Departments of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Japan.

Objective The effects of partial pressure of arterial oxygen (PaO) after introducing long-term noninvasive ventilation (NIV) on the prognosis of patients with restrictive thoracic disease and chronic respiratory failure are not exactly known. Methods Data from 141 patients with restrictive thoracic disease under long-term nocturnal NIV were retrospectively examined. We divided the patients into 2 groups according to the daytime PaO value while breathing spontaneously with prescribed oxygen at 12 months after introducing NIV: PaO≥80 Torr group (n=76) and PaO<80 Torr group (n=65). Read More

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http://dx.doi.org/10.2169/internalmedicine.1860-18DOI Listing
January 2019

High flow nasal therapy in immunocompromised patients with acute respiratory failure: A systematic review and meta-analysis.

J Crit Care 2018 Dec 29;50:250-256. Epub 2018 Dec 29.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy.

Purpose: The role of high-flow nasal therapy (HFNT) as compared to conventional oxygen therapy (COT) in immunocompromised patients admitted to intensive care unit (ICU) with acute respiratory failure (ARF) remains unclear. We conducted a systematic review and meta-analysis in order to address this issue.

Methods: We searched PubMed, Medline and Embase until November 7th, 2018. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.015DOI Listing
December 2018

The Use of Noninvasive Ventilation with High Frequency in Newborns-A Single-Center Experience.

Am J Perinatol 2019 Jan 8. Epub 2019 Jan 8.

Department of Neonatal Diseases, Samodzielny Publiczny Szpital Kliniczny nr 2 Pomorskiego Uniwersytetu Medycznego, Szczecin, Zachodniopomorskie, Poland.

Objective:  The aim of the study is to evaluate the efficacy of noninvasive high-frequency ventilation (nHFV) in respiratory-deficient infants.

Study Design:  Retrospective analysis of 32 cases of nHFV in 30 term ( = 4) and preterm ( = 26) newborns using a noninvasive ventilation (NIV) device. nHFV avoided intubation of children performed with NIV and reintubation after long-term mechanical ventilation (MV). Read More

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http://dx.doi.org/10.1055/s-0038-1677471DOI Listing
January 2019

New Strategies of Pulmonary Protection of Preterm Infants in the Delivery Room with the Respiratory Function Monitoring.

Am J Perinatol 2019 Jan 8. Epub 2019 Jan 8.

Division of Neonatology, Department of Statistics Institute for Health Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Objective:  To investigate if the use of a visible respiratory function monitor (RFM) to use lower tidal volumes (Vts) during positive pressure ventilation (PPV) in the delivery room (DR) reduces the need of surfactant administration and invasive mechanical ventilation during the first 72 hours after birth of preterm infants <32 weeks' gestational age (GA).

Study Design:  Infants <32 weeks' GA ( = 106) requiring noninvasive PPV were monitored with a RFM at birth and randomized to visible ( = 54) or masked ( = 52) display on RFM. Pulmonary data were recorded during the first 10 minutes after birth. Read More

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http://dx.doi.org/10.1055/s-0038-1676828DOI Listing
January 2019

Effect of dexmedetomidine or propofol sedation on haemodynamic stability of patients after thoracic surgery.

Anaesthesiol Intensive Ther 2018 ;50(5):359-366

Department of Anaesthesiology and Intensive Therapy, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia, Katowice.

Background: Dexmedetomidine and propofol are commonly used sedative agents in non-invasive ventilation as they allow for easy arousal and are relatively well controllable. Moreover dexmedetomidine is associated with low risk of respiratory depression. However, both agents are associated with significant hemodynamic side effects. Read More

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https://journals.viamedica.pl/anaesthesiology_intensivethera
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http://dx.doi.org/10.5603/AIT.a2018.0046DOI Listing
January 2018
1 Read

Transporting Children on Noninvasive Ventilation: Doing No Harm or Doing Good?

Authors:
Felix Oberender

Pediatr Crit Care Med 2019 Jan;20(1):81-82

Paediatric Intensive Care Unit, The Monash Children's Hospital Melbourne; and, Monash University School of Medicine, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1097/PCC.0000000000001792DOI Listing
January 2019

Association of Home Respiratory Equipment and Supply Use with Health Care Resource Utilization in Children.

J Pediatr 2019 Jan 4. Epub 2019 Jan 4.

Children's Hospital Association, Lenexa, KS.

Objective: To compare health care use and spending in children using vs not using respiratory medical equipment and supplies (RMES).

Study Design: Cohort study of 20 352 children age 1-18 years continuously enrolled in Medicaid in 2013 from 12 states in the Truven Medicaid MarketScan Database; 7060 children using RMES were propensity score matched with 13 292 without RMES. Home RMES use was identified with Healthcare Common Procedure Coding System and International Classification of Diseases codes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183169
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http://dx.doi.org/10.1016/j.jpeds.2018.11.046DOI Listing
January 2019
2 Reads

Severity of illness assessment with application of the APACHE IV predicted mortality and outcome trends analysis in an academic cardiac intensive care unit.

J Crit Care 2018 Dec 24;50:242-246. Epub 2018 Dec 24.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. Electronic address:

Purpose: To assess trends in life support interventions and performance of the automated Acute Physiology and Chronic Health Evaluation (APACHE) IV model at mortality prediction compared with Oxford Acute Severity of Illness Score (OASIS) in a contemporary cardiac intensive care unit (CICU).

Methods And Materials: Retrospective analysis of adults (age ≥ 18 years) admitted to CICU from January 1, 2007, through December 31, 2015. Temporal trends were assessed with linear regression. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.012DOI Listing
December 2018

Noninvasive Ventilation and High-Flow Nasal Therapy for Children with Acute Respiratory Failure: An overview.

Sultan Qaboos Univ Med J 2018 Aug 19;18(3):e278-e285. Epub 2018 Dec 19.

Department of Child Health, Royal Hospital, Muscat, Oman.

Noninvasive ventilation (NIV) refers to the use of techniques to deliver artificial respiration to the lungs without the need for endotracheal intubation. As NIV has proven beneficial in comparison to invasive mechanical ventilation, it has become the optimal modality for initial respiratory support among children in respiratory distress. High-flow nasal (HFNC) therapy is a relatively new NIV modality and is used for similar indications. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307645PMC

A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Reducing Mortality.

J Cardiothorac Vasc Anesth 2018 Nov 22. Epub 2018 Nov 22.

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

The authors aimed to identify interventions documented by randomized controlled trials (RCTs) that reduce mortality in adult critically ill and perioperative patients, followed by a survey of clinicians' opinions and routine practices to understand the clinicians' response to such evidence. The authors performed a comprehensive literature review to identify all topics reported to reduce mortality in perioperative and critical care settings according to at least 2 RCTs or to a multicenter RCT or to a single-center RCT plus guidelines. The authors generated position statements that were voted on online by physicians worldwide for agreement, use, and willingness to include in international guidelines. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.11.026DOI Listing
November 2018

The Effectiveness of Noninvasive Positive Pressure Ventilation in Subarachnoid Pleural Fistula: A Case Report and Literature Review.

Neurospine 2018 Dec 2;15(4):394-399. Epub 2018 Oct 2.

Department of Spine Surgery, Ganga Hospital, Coimbatore, India.

Subarachnoid pleural fistula (SPF) is an aberrant communication between the pleural cavity and subarachnoid space, resulting in uncontrolled cerebrospinal fluid drainage. The negative pressure of the pleural cavity creates a continuous suctioning effect, thereby impeding the spontaneous closure of these fistulas. Dural tears or punctures in cardiothoracic procedures, spinal operations, and trauma are known to cause such abnormal communications. Read More

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http://dx.doi.org/10.14245/ns.1836056.028DOI Listing
December 2018
1 Read

Lung Ultrasound and Blood Gas-Based Classification of Critically Ill Patients with Dyspnea: A Pathophysiologic Approach.

Indian J Crit Care Med 2018 Nov;22(11):789-796

Department of CFM, AIIMS, Bhopal, Madhya Pradesh, India.

Introduction: The objective of this study was to classify dyspneic patients and to evaluate outcome variables on the basis of lung ultrasound (LUS) and arterial blood gas (ABG) findings.

Methods: We performed a retrospective chart-based review in which we included patients with dyspnea admitted to our intensive care unit (ICU) between March 2015 and August 2016. On the basis of LUS (presence of A-lines/B-lines) and ABG (hypoxia/hypercarbia), patients were classified into six groups: (i) metabolic defect (dry lung, no hypoxia); (ii) perfusion defect (dry lung, hypoxia); (iii) ventilation defect (dry lung, hypoxia, and hypercarbia); (iv) ventilation and alveolar defect (wet lung, hypoxia, and hypercarbia); (v) alveolar defect-consolidation ([wet lung] hypoxia, no echocardiographic [ECG] abnormality); (vi) alveolar defect-pulmonary edema (wet lung [usually bilateral], hypoxia, ECG abnormality). Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_338_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259439PMC
November 2018

Negative pressure pulmonary edema postextubation following medial nerve repair with sural graft surgery in a young patient: A case report.

Medicine (Baltimore) 2018 Dec;97(52):e13743

The Ohio State University Wexner Medical Center, Department of Anesthesiology.

Rationale: Negative pressure pulmonary edema (NPPE) is a serious well-described pulmonary complication. It occurs after an intense inspiratory effort against an obstructed or closed upper airway and generates a large negative airway pressure, leading to severe pulmonary edema (transvascular fluid filtration and interstitial/alveolar edema) and hypoxemia. We present a case of NPPE following general anesthesia in a patient who underwent median nerve neurorrhaphy with graft from lower left limb (sural nerve) due to sharp injury. Read More

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http://dx.doi.org/10.1097/MD.0000000000013743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314689PMC
December 2018
1 Read

[Negative pressure pulmonary edema: report of four cases and review of the literature].

Rev Bras Anestesiol 2018 Dec 24. Epub 2018 Dec 24.

Universidade Federal de Juiz de Fora (UFJF), CET-SBA do Hospital Universitário, Juiz de Fora, MG, Brasil; Universidade Federal Fluminense (UFF), Niterói, RJ, Brasil; Hospital e Maternidade Monte Sinai em Juiz de Fora, Juiz de Fora, MG, Brasil. Electronic address:

Background And Objectives: Negative pressure pulmonary edema occurs by increased intrathoracic negative pressure following inspiration against obstructed upper airway. The pressure generated is transmitted to the pulmonary capillaries and exceeds the pressure of hydrostatic equilibrium, causing fluid extravasation into the pulmonary parenchyma and alveoli. In anesthesiology, common situations such as laryngospasm and upper airway obstruction can trigger this complication, which presents considerable morbidity and requires immediate diagnosis and propaedeutics. Read More

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http://dx.doi.org/10.1016/j.bjan.2018.11.005DOI Listing
December 2018

Salbutamol Nebulization During Noninvasive Ventilation in Exacerbated Chronic Obstructive Pulmonary Disease Patients: A Randomized Controlled Trial.

J Aerosol Med Pulm Drug Deliv 2018 Dec 27. Epub 2018 Dec 27.

1 Université de Tours , Tours, France .

Background: Although nebulizing beta 2-agonists during noninvasive ventilation (NIV) could prove helpful, this administration route has to date never been studied in unstable chronic obstructive pulmonary disease (COPD) patients. We sought to demonstrate that salbutamol could be nebulized through an NIV circuit in COPD exacerbation and improve forced expiratory volume in 1 second (FEV1) as compared with placebo.

Patient And Methods: This is a bench study to determine the optimal pattern of nebulization followed by a randomized double-blind parallel-group trial comparing salbutamol and placebo aerosols delivered during NIV to 43 intensive care unit patients. Read More

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http://dx.doi.org/10.1089/jamp.2018.1484DOI Listing
December 2018

Expansion Thoracoplasty as a Life-Saving Procedure in an Adolescent With Severe Spinal Deformity and Sacral Agenesis.

Spine Deform 2019 Jan;7(1):171-175

University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA; Arkansas Children's Hospital, 1 Children's Way, Little Rock, AR 72202, USA.

Study Design: Case report.

Objectives: To describe use of expansion thoracoplasty (ET) for severe thoracic insufficiency syndrome (TIS) in an adolescent with severe spinal deformity.

Background: ET is typically performed in young patients with TIS to increase chest cavity volume, improve alveolar expansion, and potentially improve alveolar proliferation. Read More

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http://dx.doi.org/10.1016/j.jspd.2018.06.002DOI Listing
January 2019

The Effect of High-Flow Nasal Oxygen Therapy on Postoperative Pulmonary Complications and Hospital Length of Stay in Postoperative Patients: A Systematic Review and Meta-Analysis.

J Intensive Care Med 2018 Dec 26:885066618817718. Epub 2018 Dec 26.

1 Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Objective:: To evaluate the effect of high-flow nasal cannula oxygen (HFNO) therapy on hospital length of stay (LOS) and postoperative pulmonary complications (PPCs) in adult postoperative patients.

Data Sources:: PubMed, Embase, the Cochrane Library, Web of Science of Studies, China National Knowledge Index, and Wan Fang databases were searched until July 2018.

Study Selection:: Randomized controlled trials (RCTs) comparing HFNO with conventional oxygen therapy or noninvasive mechanical ventilation in adult postoperative patients were included. Read More

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http://dx.doi.org/10.1177/0885066618817718DOI Listing
December 2018

Home Mechanical Ventilation Use in South Korea Based on National Health Insurance Service Data.

Respir Care 2018 Dec 24. Epub 2018 Dec 24.

Department of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea.

Background: In Asian countries, nationwide data on patients undergoing home mechanical ventilation are limited.

Methods: This study investigated the prevalence and primary indications for home mechanical ventilation use in South Korea by using nationwide registry data from the National Health Insurance Service.

Results: The study period included a total of 4,785 subjects on home mechanical ventilation (mean ± SD age, 56. Read More

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http://rc.rcjournal.com/lookup/doi/10.4187/respcare.06310
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http://dx.doi.org/10.4187/respcare.06310DOI Listing
December 2018
5 Reads

Carbon dioxide pneumothorax following retroperitoneal laparoscopic partial nephrectomy: a case report and literature review.

BMC Anesthesiol 2018 Dec 22;18(1):202. Epub 2018 Dec 22.

Departments of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, 100034, China.

Background: Laparoscopy has many advantages when used to assist surgery. However, pneumothorax, as a rare but potentially life-threatening complication, it requires rapid recognition and treatment. CO pneumothorax may be distinct from air pneumothorax. Read More

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http://dx.doi.org/10.1186/s12871-018-0662-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303981PMC
December 2018
1 Read

Noninvasive Ventilation after Surgical Myocardial Revascularization for Left-Ventricular Dysfunction: A Hypothesis-Generating Study.

Respir Care 2019 Jan;64(1):115-116

Cardiac Surgery Division Clinica Montevergine, GMV Health Care and Research Mercogliano, Italy.

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http://dx.doi.org/10.4187/respcare.06510DOI Listing
January 2019

[Design of Experiment Platform for Noninvasive Ventilator Based on LabVIEW].

Zhongguo Yi Liao Qi Xie Za Zhi 2018 Nov;42(6):431-433

School of Engineering, Sun Yat-sen University, Guangzhou, 510006.

Objective: The study presents an experiment platform to perform ventilation and develop the control strategy for ventilator.

Methods: The software designed by LabVEIW displays and saves data in ventilation support through connecting with data acquisition device and signal processing circuit, which is improved by control strategy in order to achieve the more scientific ventilation.

Results: The experiment platform realizes the ventilation support and is close to the data outputted from ventilator. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2018.06.011DOI Listing
November 2018

Noninvasive ventilation in acute hypoxemic respiratory failure: A systematic review and meta-analysis. Response to letter.

J Crit Care 2018 Dec 3. Epub 2018 Dec 3.

Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil; CEPI - Centro de Ensino Pesquisa e Inovação -Hospital Marcelino Champagnat, Curitiba, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2018.11.035DOI Listing
December 2018

Routine admission to step-down unit as an alternative to intensive care unit after pediatric supraglottoplasty.

Int J Pediatr Otorhinolaryngol 2019 Jan 3;116:181-185. Epub 2018 Nov 3.

Dept. Otolaryngology - Head & Neck Surgery, Baylor College of Medicine, Houston, TX, USA; Texas Children's Hospital, Houston, TX, USA. Electronic address:

Objective: To evaluate the feasibility and the outcomes for step-down (SD) unit admission as an alternative to intensive care unit (ICU) admission after supraglottoplasty in the pediatric patient.

Methods: A review of 98 patients who underwent supraglottoplasty from 2012 to 2017 at a tertiary referral pediatric hospital was performed. An SD unit had 1-to-3 nurse-to-patient ratio with noninvasive positive pressure ventilation capability. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.11.003DOI Listing
January 2019

Health outcomes in spinal muscular atrophy type 1 following AVXS-101 gene replacement therapy.

Pediatr Pulmonol 2019 Feb 12;54(2):179-185. Epub 2018 Dec 12.

Department of Pediatrics, Ohio State University, Columbus, Ohio.

Background: Spinal Muscular Atrophy type 1 (SMA1) is a rare genetic neuromuscular disease where 75% of SMA1 patients die/require permanent-ventilation by 13.6 months. This study assessed the health outcomes of SMA1 infants treated with AVXS-101 gene replacement therapy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24203
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http://dx.doi.org/10.1002/ppul.24203DOI Listing
February 2019
5 Reads

Effect of Jet Nebulization on Noninvasive Positive-Pressure Ventilation Administered with Noninvasive or Intensive Care Unit Ventilators: A Bench Study.

Respiration 2018 Dec 13:1-8. Epub 2018 Dec 13.

Background: Most of the patients on noninvasive positive pressure ventilation require aerosol inhalation therapy to moisturize the airways or deliver drugs in acute settings. However, the effect of jet nebulization on noninvasive positive pressure ventilation (NPPV) has not been determined.

Objectives: This study was designed to investigate the impact of jet nebulization on NPPV applied in ventilators. Read More

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http://dx.doi.org/10.1159/000494456DOI Listing
December 2018
2.593 Impact Factor

Severity of Retrognathia and Glossoptosis Does Not Predict Respiratory and Feeding Disorders in Pierre Robin Sequence.

Front Pediatr 2018 20;6:351. Epub 2018 Nov 20.

Department of Pediatrics, APHP, Hôpital Universitaire Necker-Enfants Malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Pierre Robin sequence (PRS) may lead to life-threatening respiratory and feeding disorders. With the aim to analyse the association of the severities of retrognathia and glossoptosis with those of respiratory and feeding disorders, we retrospectively studied a series of 50 infants with retrognathia, glossoptosis, cleft palate, and airway obstruction. The patients were managed from birth to at least 6 years of age by a single pediatric team at the Armand Trousseau Hospital in Paris within a 12 years period (2000-2012). Read More

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http://dx.doi.org/10.3389/fped.2018.00351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256711PMC
November 2018
2 Reads

National survey: current prevalence and characteristics of home mechanical ventilation in Hungary.

BMC Pulm Med 2018 Dec 6;18(1):190. Epub 2018 Dec 6.

Department of Anesthesiology and Intensive Therapy, Semmelweis University, 1082 Üllői út 78B, Budapest, Hungary.

Background: Home mechanical ventilation is an established treatment for chronic respiratory failure resulting in improved survival and quality of life. Technological advancement, evolving health care reimbursement systems and newly implemented national guidelines result in increased utilization worldwide. Prevalence shows great geographical variations and data on East-Central European practice has been scarce to date. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-018-0754-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282340PMC
December 2018
6 Reads

Impact of Spontaneous Breathing Trial on Work of Breathing Indices Derived From Esophageal Pressure, Electrical Activity of the Diaphragm, and Oxygen Consumption in Children.

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

Pediatric Intensive Care Unit, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montreal, Québec, Canada.

Background: The present study aimed to characterize the behavior of 3 components of respiratory muscle function during mechanical ventilation weaning in children to better understand the respective impact of a spontaneous breathing trial on ventilatory mechanical action (esophageal pressure [P], ventilatory demand (electrical activity of the diaphragm [EA]), and oxygen consumption.

Methods: This was a prospective single-center study. All children ≥ 1 months and <18 y old who were intubated and on mechanical ventilation, and who were hospitalized in the pediatric ICU were eligible. Read More

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http://rc.rcjournal.com/lookup/doi/10.4187/respcare.06351
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http://dx.doi.org/10.4187/respcare.06351DOI Listing
December 2018
1 Read

Early extubation followed by immediate noninvasive ventilation vs. standard extubation in hypoxemic patients: a randomized clinical trial.

Intensive Care Med 2018 Dec 10. Epub 2018 Dec 10.

Anestesia e Rianimazione, Dipartimento di Scienze Mediche e Chirurgiche, Università "Magna Graecia", Viale Europa (Loc. Germaneto), Catanzaro, Italy.

Purpose: Noninvasive ventilation (NIV) may facilitate withdrawal of invasive mechanical ventilation (i-MV) and shorten intensive care unit (ICU) length of stay (LOS) in hypercapnic patients, while data are lacking on hypoxemic patients. We aim to determine whether NIV after early extubation reduces the duration of i-MV and ICU LOS in patients recovering from hypoxemic acute respiratory failure.

Methods: Highly selected non-hypercapnic hypoxemic patients were randomly assigned to receive NIV after early or standard extubation. Read More

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http://dx.doi.org/10.1007/s00134-018-5478-0DOI Listing
December 2018
2 Reads

The genetics of congenital central hypoventilation syndrome: clinical implications.

Appl Clin Genet 2018 15;11:135-144. Epub 2018 Nov 15.

Division of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA,

Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder of the autonomic nervous system (ANS) and respiratory control. This disorder, formerly referred to as Ondine's curse, is due to a mutation in the gene that affects the development of the neural crest cells. CCHS has an autosomal dominant pattern of inheritance. Read More

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http://dx.doi.org/10.2147/TACG.S140629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241683PMC
November 2018
3 Reads

Optimizing respiratory management in resource-limited settings.

Curr Opin Crit Care 2019 Feb;25(1):45-53

Department of Intensive Care.

Purpose Of Review: This review focuses on the emerging body of literature regarding the management of acute respiratory failure in low- and middle-income countries (LMICs). The aim is to abstract management principles that are of relevance across a variety of settings where resources are severely limited.

Recent Findings: Mechanical ventilation is an expensive intervention associated with considerable mortality and a high rate of iatrogenic complications in many LMICs. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000568DOI Listing
February 2019

Detection and management of dyspnea in mechanically ventilated patients.

Curr Opin Crit Care 2019 Feb;25(1):86-94

Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique.

Purpose Of Review: In ICU patients, dyspnea is one of the most prominent and distressing symptom. We sought to summarize current data on the prevalence and prognostic influence of dyspnea in the ICU setting and to provide concise and useful information for dyspnea detection and management.

Recent Findings: As opposed to pain, dyspnea has been a neglected symptom with regard to detection and management. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000574DOI Listing
February 2019
1 Read

Non-invasive positive pressure ventilation in pneumonia outside Intensive Care Unit: An Italian multicenter observational study.

Eur J Intern Med 2018 Oct 24. Epub 2018 Oct 24.

Emergency Department Papa Giovanni XXIII Hospital, Bergamo, Italy.

Background And Objective: Non-Invasive Ventilation (NIV) represents a standard of care to treat some acute respiratory failure (ARF). Data on its use in pneumonia are lacking, especially in a setting outside the Intensive Care Unit (ICU). The aims of this study were to evaluate the use of NIV in ARF due to pneumonia outside the ICU, and to identify risk factors for in-hospital mortality. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.09.025DOI Listing
October 2018
2 Reads

Resource use, characteristics and outcomes of prolonged non-invasive ventilation: a single-centre observational study in China.

BMJ Open 2018 Dec 4;8(12):e019271. Epub 2018 Dec 4.

Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.

Objective: To report the resource use, characteristics and outcomes of patients with prolonged non-invasive ventilation (NIV).

Design: A single-centre observational study.

Setting: An intensive care unit of a teaching hospital. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-019271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286472PMC
December 2018
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Practical Implementation of a Single-Night Split-Titration Protocol With BPAP-ST and AVAPS in Patients With Neuromuscular Disease.

J Clin Sleep Med 2018 Dec 15;14(12):2031-2035. Epub 2018 Dec 15.

Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Study Objectives: At the sleep laboratory, noninvasive positive pressure ventilation titration protocols in patients with neuromuscular disease (NMD) are based on standard pressure cycle devices in a spontaneous/timed mode (BPAP-ST). Experience integrating protocols on average volume-assured pressure support (AVAPS) mode is limited, prompting us to develop a practical single-night titration protocol that provides information to assist clinicians and patients as they decide between BPAP-ST and AVAPS modes.

Methods: We implemented a sequential titration protocol of BPAP-ST followed by AVAPS during a single-night polysomnography study in patients with NMD and reported polysomnographic and clinical metrics. Read More

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http://dx.doi.org/10.5664/jcsm.7530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287715PMC
December 2018
1 Read
3.053 Impact Factor

Detecting Early Markers of Ventilator-Associated Pneumonia by Analysis of Exhaled Gas.

Crit Care Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Anesthesiology, University Medical Center Göttingen, Göttingen, Germany.

Objectives: The detection of microbial volatile organic compounds or host response markers in the exhaled gas could give an earlier diagnosis of ventilator-associated pneumonia. Gas chromatography-ion mobility spectrometry enables noninvasive, rapid, and sensitive analysis of exhaled gas. Using a rabbit model of ventilator-associated pneumonia we determined if gas chromatography-ion mobility spectrometry is able to detect 1) ventilator-associated pneumonia specific changes and 2) bacterial species-specific changes in the exhaled gas. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003573DOI Listing
November 2018
1 Read

Noninvasive Ventilation After Thoracoabdominal Aortic Surgery: A Pilot Randomized Controlled Trial.

J Cardiothorac Vasc Anesth 2018 Nov 2. Epub 2018 Nov 2.

Department of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano Milan, Italy.

Objective: To assess the beneficial effects of noninvasive ventilation in treating postoperative pulmonary complications in patients undergoing thoracoabdominal aortic aneurysm (TAAA) open repair surgery.

Design: Randomized controlled trial.

Setting: University tertiary-care hospital. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.10.041DOI Listing
November 2018
2 Reads

Critical Care of Neuromuscular Disorders.

Continuum (Minneap Minn) 2018 12;24(6):1753-1775

Purpose Of Review: Weakness is a common reason patients are seen in neurologic consultation. This article reviews the differential diagnosis of neuromuscular disorders in the intensive care unit (ICU), discusses the intensive care needs and evaluation of respiratory failure in patients with neuromuscular disorders, and provides a practical guide for management.

Recent Findings: Although primary neuromuscular disorders used to be the most common cause for weakness from peripheral nervous system disease in the ICU, a shift toward ICU-acquired weakness is observed in today's clinical practice. Read More

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http://dx.doi.org/10.1212/CON.0000000000000682DOI Listing
December 2018
6 Reads

Noninvasive approach for de novo acute hypoxemic respiratory failure: noninvasive ventilation, high-flow nasal cannula, both or none?

Curr Opin Crit Care 2019 Feb;25(1):54-62

Critical Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.

Purpose Of Review: To summarize the recent evidence regarding the use of noninvasive strategies for de novo acute hypoxemic respiratory failure (AHRF).

Recent Findings: New guidelines for the use of noninvasive ventilation (NIV) in acute respiratory failure have been published. In parallel, high-flow nasal cannula (HFNC) is an emerging noninvasive strategy for AHRF patients. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000570DOI Listing
February 2019

Noninvasive high-frequency oscillatory ventilation versus nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome: A randomized controlled trial.

J Matern Fetal Neonatal Med 2018 Dec 4:1-151. Epub 2018 Dec 4.

a Department of Pediatrics , Imam Khomeini Hospital , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Background: Respiratory distress syndrome is one of the main causes of mortality in premature neonates. Treatment of these neonates with invasive mechanical ventilation has side effects such as chronic pulmonary diseases. Noninvasive ventilation, such as nasal continuous positive airway pressure (NCPAP) and nasal high-frequency oscillation ventilation (NHFOV), has shown to reduce the burden of chronic lung disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1555810DOI Listing
December 2018
11 Reads

Clinical validation of a risk scale for serious outcomes among patients with chronic obstructive pulmonary disease managed in the emergency department.

CMAJ 2018 Dec;190(48):E1406-E1413

Departments of Emergency Medicine (Stiell, Calder, Perry) and Medicine (Aaron, Forster), Clinical Epidemiology Program, Ottawa Hospital Research Institute (Stiell, Perry, Clement, Aaron, Forster, Brinkhurst), University of Ottawa Heart Institute (Wells), University of Ottawa, Ottawa, Ont.; Division of Emergency Medicine, Department of Family and Community Medicine (Borgundvaag), University of Toronto, Toronto, Ont.; Department of Emergency Medicine (Brison), Kingston Health Sciences Centre, Kingston, Ont.; Department of Emergency Medicine (McRae), University of Calgary, Calgary, Alta.; Department of Emergency Medicine and School of Public Health, University of Alberta, and Alberta Health Services (Rowe), Edmonton, Alta.

Background: The Ottawa chronic obstructive pulmonary disease (COPD) Risk Scale (OCRS), which consists of 10 criteria, was previously derived to identify patients in the emergency department with COPD who were at high risk for short-term serious outcomes. We sought to validate, prospectively and explicitly, the OCRS when applied by physicians in the emergency department.

Methods: We conducted this prospective cohort study involving patients in the emergency departments at 6 tertiary care hospitals and enrolled adults with acute exacerbation of COPD from May 2011 to December 2013. Read More

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http://dx.doi.org/10.1503/cmaj.180232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258211PMC
December 2018
6 Reads

The multidimensional nature of dyspnoea in amyotrophic lateral sclerosis patients with chronic respiratory failure: Air hunger, anxiety and fear.

Respir Med 2018 Dec 17;145:1-7. Epub 2018 Oct 17.

Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pneumologie et Réanimation Médicale du Département R3S, F-75013, Paris, France.

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder leading to chronic respiratory failure. Few studies have investigated ALS-related dyspnoea, and none have characterised the emotional distress it inflicts. We hypothesised that ALS-related dyspnoea has a strong affective component that relates to quality of life. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.10.010DOI Listing
December 2018
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Follow-up outcomes of chronic obstructive pulmonary disease patients who underwent dilatation and curettage with the Karakoca resector balloon: A 188-case series over 5 years.

Medicine (Baltimore) 2018 Nov;97(48):e13400

Medical Park Gaziosmanpaşa Hospital, Istanbul, Turkey.

We previously reported satisfactory results with the Karakoca resector balloon in 10 patients with stage IV chronic obstructive pulmonary disease (COPD) who did not respond to medical treatment. In this article, we present the outcomes of the Karakoca resector balloon dilatation and curettage technique in a larger case series (n = 188).A total of 188 COPD patients [mean age (SD): 69. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811300-0005
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http://dx.doi.org/10.1097/MD.0000000000013400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283145PMC
November 2018
6 Reads

Decreasing re-intubation using prophylactic noninvasive ventilation in elderly patients: A propensity-matched study.

J Crit Care 2018 Nov 22;50:77-81. Epub 2018 Nov 22.

Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.

Purpose: Prophylactic noninvasive ventilation (NIV) reduces re-intubation in high-risk patients. However, its effects in elderly patients remain unclear. Here, we investigated the efficacy of prophylactic NIV in elderly patients after a planned extubation. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.11.019DOI Listing
November 2018
1 Read

Sedation and neurodevelopmental outcomes in PICU: Identification of study groups.

Paediatr Anaesth 2018 Nov 25. Epub 2018 Nov 25.

Department of Anesthesia, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.

Background/aims: As little as 30 minutes of exposure to anesthetic and sedative agents may adversely affect the developing brain. Safe, humane management of critically ill infants requires the use of sedative agents, often for prolonged periods. We sought to identify two comparable groups of critical care patients who did or did not receive sedatives, with the aim of designing a long-term neurodevelopment follow-up study. Read More

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http://dx.doi.org/10.1111/pan.13558DOI Listing
November 2018
7 Reads

Survival of amyotrophic lateral sclerosis patients after admission to the intensive care unit for acute respiratory failure: an observational cohort study.

J Crit Care 2018 Nov 12;50:54-58. Epub 2018 Nov 12.

AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pneumologie, Médecine Intensive et Réanimation, Départment "R3S", F-75013 Paris, France; Sorbonne Université, INSERM, UMRS1158 Neurophysiologie respiratoire expérimentale et clinique, F-75005 Paris, France. Electronic address:

Purpose: Amyotrophic lateral sclerosis (ALS) entails a risk of acute respiratory failure (ARF). The decision to admit such patients to the intensive care unit (ICU) is difficult given the inexorable prognosis of ALS. To fuel this discussion, this study describes the ICU and post-ICU survival of ALS-related ARF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183125
Publisher Site
http://dx.doi.org/10.1016/j.jcrc.2018.11.007DOI Listing
November 2018
7 Reads

The Importance of Synchronization During Neonatal Noninvasive Ventilation.

Authors:
Robert M DiBlasi

Respir Care 2018 Dec;63(12):1579-1582

Department of Respiratory Care Seattle Children's Hospital and Research Institute Seattle, Washington

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http://dx.doi.org/10.4187/respcare.06741DOI Listing
December 2018
1 Read