7,019 results match your criteria Noninvasive Ventilation


Failure of early extubation among cases of coronavirus disease-19 respiratory failure: Case report and clinical experience.

Medicine (Baltimore) 2020 Jul;99(27):e20843

Department of Emergency, the First Affiliated Hospital, Zhejiang University, Hangzhou, China.

Rationale: Extubation strategy for mechanically ventilated patients with Coronavirus Disease 19 is different from that for patients with other viral pneumonia. We reported 2 cases of Coronavirus Disease 19 receiving tracheal intubation twice during the hospitalization.

Patient Concerns: Two elderly patients with onset of fever and upper respiratory tract infection were confirmed as Coronavirus Disease 19, 1 of whom had chronic obstructive pulmonary disease previously. Read More

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http://dx.doi.org/10.1097/MD.0000000000020843DOI Listing

A quality improvement initiative for COPD patients: A cost analysis.

PLoS One 2020 6;15(7):e0235040. Epub 2020 Jul 6.

Philips, Sleep & Respiratory Care, Pittsburgh, PA, United States of America.

The objective of this analysis was to evaluate and report on the economic impact of implementing an integrated, quality, and operational improvement program on chronic obstructive pulmonary disease (COPD) care from acute through post-acute care settings. This initiative was established in a cohort of 12 hospitals in Alabama and sought to address COPD readmission through improved workflows pertaining to early diagnosis, efficient care transitions, and patient visibility across the entire care episode. Implementation of the initiative was influenced by lean principles, particularly cross-functional agreement of workflows to improve COPD care delivery and outcomes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235040PLOS

Evaluation of the new expert consensus-based definition of selective fetal growth restriction in monochorionic pregnancies.

J Matern Fetal Neonatal Med 2020 Jul 6:1-7. Epub 2020 Jul 6.

Department of Obstetrics and Gynecology, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium.

To compare the outcomes of a cohort of monochorionic pregnancies with selective fetal growth restriction (sFGR) diagnosed according to the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) definition published in 2015 with a cohort considered as sFGR according to new expert consensus-based diagnostic parameters published in 2019. This was a retrospective study, conducted between January 1st 2010 and July 30th 2019. We reviewed the medical records of all the monochorionic pregnancies followed in our center including perinatal outcomes. Read More

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http://dx.doi.org/10.1080/14767058.2020.1786053DOI Listing

Noninvasive Respiratory Management of Spinal Cord Injury.

Phys Med Rehabil Clin N Am 2020 Aug 6;31(3):397-413. Epub 2020 May 6.

Department of PM&R, Icahn School of Medicine at Mount Sinai, 3 East 101th Street, New York, NY 10029, USA.

Intubated ventilator-dependent patients with high-level spinal cord injury can be managed without tracheostomy tubes provided that they have sufficient cognition to cooperate and that any required surgical procedures are completed and they are medically stable. Intubation for a month or more than extubation to continuous noninvasive ventilatory support (NVS) can be safer long term than resort to tracheotomy. Noninvasive ventilation (NIV) is not conventionally being used for ventilatory support. Read More

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http://dx.doi.org/10.1016/j.pmr.2020.03.006DOI Listing

Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China.

Crit Care Med 2020 Jun 23. Epub 2020 Jun 23.

National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Objectives: The outbreak of coronavirus disease 2019 is becoming a worldwide pandemic. Mechanical ventilation is lifesaving for respiratory distress, this study was designed to delineate the clinical features of the coronavirus disease 2019 patients with mechanical ventilation from a national cohort in China.

Design: Prospective observational study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314346PMC

Novel use of high-flow nasal cannula therapy in the management of pyriform aperture stenosis: case report.

J Laryngol Otol 2020 Jun;134(6):558-561

Department of Otolaryngology, Sydney Children's Hospital, Randwick, Australia.

Background: Pyriform aperture stenosis is a rare form of congenital nasal obstruction; it poses a management dilemma for otolaryngologists and physicians alike. It can result in poor weight gain and potentially life-threatening airflow obstruction. The challenge lies in the difficulty to predict which patients will require invasive operative management versus conservative therapy alone. Read More

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http://dx.doi.org/10.1017/S002221512000119XDOI Listing

Value of lung ultrasonography to predict weaning success in ventilated neonates.

Pediatr Pulmonol 2020 Jul 1. Epub 2020 Jul 1.

Department of Pediatrics, Tanta University Hospital, Tanta, Egypt.

Background: Invasive mechanical ventilation (MV) is lifesaving for critically ill neonates. Limiting the duration of MV support is crucial. Lung ultrasonography is a bedside technique useful to predict weaning success in adults, but few data are available about its use in neonates. Read More

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http://dx.doi.org/10.1002/ppul.24934DOI Listing

Impact of Body Position on Lung Deposition of Nebulized Surfactant in Newborn Piglets on Nasal Continuous Positive Airway Pressure.

Neonatology 2020 Jun 30:1-7. Epub 2020 Jun 30.

Department of Pediatric Anesthesia and Intensive Care, Skåne University Hospital, Lund, Sweden.

Introduction: The ideal body position during surfactant nebulization is not known.

Objective: The aim of this study was to determine whether body positioning during surfactant nebulization influences surfactant distribution and deposition in the lungs.

Methods: Twenty-four 12- to 36-h-old full-termpiglets (1. Read More

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http://dx.doi.org/10.1159/000508349DOI Listing

Importance of respiratory airway management as well as psychological and rehabilitative treatments to COVID-19 patients.

Am J Emerg Med 2020 Apr 30. Epub 2020 Apr 30.

Department of Critical Care Medicine, Shenzhen People's Hospital, Shenzhen, China. Electronic address:

The clinical therapy for severe 2019 coronavirus disease (i.e., COVID-19) sufferers is relatively challenging. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.04.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192120PMC

Comparison of Nasal CPAP versus Bi-level CPAP in Transient Tachypnea of the Newborn: A Randomized Trial.

Am J Perinatol 2020 Jun 28. Epub 2020 Jun 28.

Division of Neonatology, Ankara City Hospital, The University of Health Sciences, Ankara, Turkey.

Objective:  The optimal noninvasive ventilation (NIV) modality in the treatment of transient tachypnea of the newborn (TTN) is still unknown. The aim of this study was to compare nasal continuous positive airway pressure (NCPAP) versus bi-level CPAP in the treatment of TTN.

Study Design:  This was a prospective randomized study that was conducted in a tertiary level neonatal intensive care unit of Zekai Tahir Burak Women's Health Education and Research Hospital during the 1-year period between April 2017 and March 2018. Read More

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http://dx.doi.org/10.1055/s-0040-1713815DOI Listing

Analysis of clinical features and early warning signs in patients with severe COVID-19: A retrospective cohort study.

PLoS One 2020 26;15(6):e0235459. Epub 2020 Jun 26.

Medical Records Management Department, The First Affiliated Hospital of Zhenghzou University, Zhengzhou, Henan, China.

Coronavirus disease 2019 (COVID-19) was first identified in Wuhan, China, in December 2019. Although previous studies have described the clinical aspects of COVID-19, few studies have focused on the early detection of severe COVID-19. Therefore, this study aimed to identify the predictors of severe COVID-19 and to compare clinical features between patients with severe COVID-19 and those with less severe COVID-19. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235459PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319317PMC

Evolution of Pediatric Home Mechanical Ventilation Program in Serbia-What Has Changed in the Last Decade.

Front Pediatr 2020 10;8:261. Epub 2020 Jun 10.

Department of Pulmonology, Mother and Child Health Care Institute, Belgrade, Serbia.

Home mechanical ventilation (HMV) is a method of treatment in children with sleep-disordered breathing (SDB) and alveolar hypoventilation regardless of primary disease. The goal of the study was to describe the changes in the HMV program in Serbia during the last two decades. Cross-sectional retrospective study included data from the national HMV database from 2001 until 2019. Read More

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http://dx.doi.org/10.3389/fped.2020.00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298115PMC

Impact of Interface Type on Noninvasive Ventilation Efficacy in Patients With Neuromuscular Disease: A Randomized Cross-Over Trial.

Arch Bronconeumol 2020 Jun 22. Epub 2020 Jun 22.

University Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, 38000 Grenoble, France; AGIR à dom. Association, Meylan F-38240, France.

Background And Objective: Around 25% of patients with neuro-muscular diseases (NMD) are treated by home noninvasive ventilation (NIV) through an oronasal mask. However, there is growing evidence that nasal masks require lower NIV pressures and result in fewer residual obstructive events. We hypothesized that nasal masks would improve efficacy and reduce side effects compared to oronasal masks in this population. Read More

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http://dx.doi.org/10.1016/j.arbres.2020.05.024DOI Listing

Respiratory outcomes of metformin use in patients with type 2 diabetes and chronic obstructive pulmonary disease.

Sci Rep 2020 Jun 24;10(1):10298. Epub 2020 Jun 24.

Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2 Shi-Pai Rd., Chung-Cheng Build. 11F Room522, Taipei, 11217, Taiwan.

Few studies investigated the respiratory outcomes of metformin use in patients with coexistent type 2 diabetes mellitus (T2DM) and chronic obstructive pulmonary disease (COPD). We want to compare the long-term respiratory endpoints of metformin use and nonuse in patients with T2DM and COPD. This retrospective cohort study enrolled patients with T2DM and COPD from Taiwan's National Health Insurance Program between January 1, 2000, and December 31, 2012. Read More

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http://dx.doi.org/10.1038/s41598-020-67338-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314747PMC

Mouthpiece ventilation in the management of dyspnea: A single-arm pilot study.

Palliat Med 2020 Jun 24:269216320935003. Epub 2020 Jun 24.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Background: Noninvasive ventilation may relieve dyspnea in advanced diseases, but noninvasive ventilation through mouthpiece has not been tested in palliative care.

Aim: To assess the feasibility of mouthpiece ventilation in relieving dyspnea among patients with advanced disease.

Design: In this prospective single-arm pilot study, the change in dyspnea by mouthpiece ventilation was measured with numeric rating scale (0-10) and 100-mm visual analogue scale. Read More

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http://dx.doi.org/10.1177/0269216320935003DOI Listing

[Application of acute physiology and chronic health evaluation II score in the timing of noninvasive ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 May;32(5):581-584

Department of Respiratory and Critical Care Medicine, Central South University Xiangya School of Medicine Affiliated Haikou Hospital (Haikou People's Hospital), Haikou 570208, Hainan, China. Corresponding author: Zeng Cimei, Email:

Objective: To explore the application of acute physiology and chronic health evaluation II (APACHE II) score in the timing and nursing of noninvasive ventilation for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Methods: 106 AECOPD patients admitted to Haikou People's Hospital from January 2018 to October 2019 were selected as the study objects. According to the method of random number table, the patients were divided into observation group and control group, with 53 patients in each group. Read More

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http://dx.doi.org/10.3760/cma.j.cn121430-20200106-00159DOI Listing

Preventive use of respiratory support after scheduled extubation in critically ill medical patients-a network meta-analysis of randomized controlled trials.

Crit Care 2020 06 22;24(1):370. Epub 2020 Jun 22.

Department of Intensive Care Medicine, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, 315000, Zhejiang, China.

Background: Respiratory support has been increasingly used after extubation for the prevention of re-intubation and improvement of prognosis in critically ill medical patients. However, the optimal respiratory support method is still under debate. This network meta-analysis (NMA) aims to evaluate the comparative effectiveness of various respiratory support methods used for preventive purposes after scheduled extubation in critically ill medical patients. Read More

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http://dx.doi.org/10.1186/s13054-020-03090-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306939PMC

Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: Results from a single Italian Centre study on tocilizumab versus standard of care.

J Clin Virol 2020 May 15;129:104444. Epub 2020 May 15.

Infectious Diseases Unit, ASUFC, Udine, Italy.

Objective: Approximately 5% of patients with coronavirus disease 2019 (COVID-19) develop a life-threatening pneumonia that often occurs in the setting of increased inflammation or "cytokine storm". Anti-cytokine treatments are being evaluated but optimal patient selection remains unclear, and the aim of our study is to address this point.

Methods: Between February 29 to April 6, 2020, 111 consecutive hospitalized patients with COVID-19 pneumonia were evaluated in a single centre retrospective study. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104444DOI Listing

High Breath-by-Breath Variability Is Associated With Extubation Failure in Children.

Crit Care Med 2020 Jun 16. Epub 2020 Jun 16.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, CA.

Objectives: Extubation failure is multifactorial, and most tools to assess extubation readiness only evaluate snapshots of patient physiology. Understanding variability in respiratory variables may provide additional information to inform extubation readiness assessments.

Design: Secondary analysis of prospectively collected physiologic data of children just prior to extubation during a spontaneous breathing trial. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004418DOI Listing

Position Paper for the State-of-the-Art Application of Respiratory Support in Patients with COVID-19.

Respiration 2020 Jun 19:1-21. Epub 2020 Jun 19.

Innere Medizin V: Pneumologie, Allergologie, Beatmungs- und Umweltmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.

Against the background of the pandemic caused by infection with the SARS-CoV-2 virus, the German Respiratory Society has appointed experts to develop therapy strategies for COVID-19 patients with acute respiratory failure (ARF). Here we present key position statements including observations about the pathophysiology of (ARF). In terms of the pathophysiology of pulmonary infection with SARS-CoV-2, COVID-19 can be divided into 3 phases. Read More

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http://dx.doi.org/10.1159/000509104DOI Listing

Prevalence of Taste and Smell Dysfunction in Coronavirus Disease 2019.

JAMA Otolaryngol Head Neck Surg 2020 Jun 18. Epub 2020 Jun 18.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Importance: Early diagnosis of coronavirus disease 2019 (COVID-19) may help control the diffusion of the disease into the population.

Objective: To investigate the presence of sinonasal manifestations at the onset of COVID-19 to achieve an earlier diagnosis.

Design, Setting, And Participants: This retrospective telephone survey study investigated patients diagnosed with COVID-19 from March 5 to March 23, 2020, who were hospitalized or discharged from a single referral center. Read More

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http://dx.doi.org/10.1001/jamaoto.2020.1155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303892PMC

COVID-19 in pregnancy was associated with maternal morbidity and preterm birth.

Am J Obstet Gynecol 2020 Jun 15. Epub 2020 Jun 15.

Department of Obstetrics and Gynecology, Strasbourg University Hospitals, Strasbourg, France.

Background: Despite the mainly reassuring outcomes for pregnant women with COVID-19 infection reported by previous case series with small sample sizes, some recent reports of severe maternal morbidity requiring intubation and of maternal deaths show the need for additional data about the impact of COVID-19 on pregnancy outcomes. This study aimed to report the maternal characteristics and clinical outcomes of pregnant women with COVID-19 disease.

Study Design: This retrospective single-center study includes all consecutive pregnant women with confirmed (laboratory-confirmed) or suspected (according to version 7. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294260PMC

COVID-19: how to transform a noninvasive ventilation device in a critical care ventilator.

Rev Esp Anestesiol Reanim 2020 May 15. Epub 2020 May 15.

Kinesiólogo Respiratorio, Miembro del Capítulo de kinesiología Intensivista y Comité de Neumonología Crítica, Sociedad Argentina de Terapia Intensiva, Buenos Aires, Argentina.

COVID-19 pandemic caused not only many deaths around the world but also made evident technical limitations of hospital and intensive care units (ICU). The growing demand of ICU ventilators in a short lapse of time constitutes one of the main community concerns. The main goal of this communication is to give simple solutions to transform a noninvasive ventilator in an invasive one for intubated patients. Read More

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http://dx.doi.org/10.1016/j.redar.2020.05.002DOI Listing

Shedding Light on Dysphagia Associated With COVID-19: The What and Why.

OTO Open 2020 Apr-Jun;4(2):2473974X20934770. Epub 2020 Jun 8.

Department of Communication Disorders, New Mexico State University, Las Cruces, New Mexico, USA.

The most common symptom of COVID-19 in critically ill patients is ARDS (acute respiratory distress syndrome), with many patients requiring invasive or noninvasive respiratory support in the intensive care unit. Oropharyngeal dysphagia may be a consequence of the respiratory-swallowing incoordination common in ARDS or may occur following the respiratory support interventions. In this commentary, we highlight the risk and complications of oropharyngeal dysphagia in patients with COVID-19 and urge medical and rehabilitation professionals to consider dysphagia a prognostic complication, provide appropriate referrals, and initiate early interventions as appropriate. Read More

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http://dx.doi.org/10.1177/2473974X20934770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281885PMC

A Rare Case of ARDS Caused by Bupropion Inhalation and Treated with Noninvasive Ventilation.

Case Rep Crit Care 2020 28;2020:5107456. Epub 2020 May 28.

Department of Pulmonary/Critical Care, Pennsylvania Hospital, University of Pennsylvania Health System (UPHS), Philadelphia PA, USA.

Acute respiratory distress syndrome, characterized by the Berlin criteria, is associated with a high mortality rate. Its treatment includes addressing the underlying etiology, general supportive measures, and achievement of effective oxygenation. New key data indicates that in a subset of patients, noninvasive ventilation techniques can be a therapeutic and equivalent alternative to traditional invasive ventilation. Read More

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http://dx.doi.org/10.1155/2020/5107456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275235PMC

A Review on Non-invasive Respiratory Support for Management of Respiratory Distress in Extremely Preterm Infants.

Front Pediatr 2020 28;8:270. Epub 2020 May 28.

Division of Neonatology, LAC+USC Medical Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States.

Majority of extremely preterm infants require positive pressure ventilatory support at the time of delivery or during the transitional period. Most of these infants present with respiratory distress (RD) and continue to require significant respiratory support in the neonatal intensive care unit (NICU). Bronchopulmonary dysplasia (BPD) remains as one of the major morbidities among survivors of the extremely preterm infants. Read More

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http://dx.doi.org/10.3389/fped.2020.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270199PMC

Sudden cardiac death due to ventricular fibrillation in a case of giant cell myocarditis.

J Cardiol Cases 2020 Jun 12;21(6):224-226. Epub 2020 Mar 12.

Department of Cardiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

A 70-year-old woman was admitted to our hospital complaining of shortness of breath. She was diagnosed with acute decompensated heart failure due to left ventricular dysfunction. Her symptoms began to improve with standard therapy for heart failure with diuretics, noninvasive pressure ventilation, and inotropes, but paroxysmal atrial fibrillation and premature ventricular contractions (PVCs) occurred. Read More

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http://dx.doi.org/10.1016/j.jccase.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283290PMC

Home Noninvasive Positive Pressure Ventilation for Chronic Obstructive Pulmonary Disease-Reply.

JAMA 2020 06;323(23):2432-2433

Mayo Clinic Evidence-Based Practice Center, Rochester, Minnesota.

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http://dx.doi.org/10.1001/jama.2020.6093DOI Listing
June 2020
35.289 Impact Factor

Home Noninvasive Positive Pressure Ventilation for Chronic Obstructive Pulmonary Disease.

JAMA 2020 06;323(23):2432

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1001/jama.2020.6090DOI Listing

Role of Helmet-Delivered Noninvasive Pressure Support Ventilation in COVID-19 Patients.

J Cardiothorac Vasc Anesth 2020 May 8. Epub 2020 May 8.

Pediatric Hematology and Oncology Unit University Hospital G. Rodolico Catania, Italy.

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http://dx.doi.org/10.1053/j.jvca.2020.04.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205670PMC

Home noninvasive positive-pressure ventilation reduces mortality and intubations in COPD with hypercapnia.

Ann Intern Med 2020 Jun;172(12):JC64

Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (M.B.S.).

Source Citation: Wilson ME, Dobler CC, Morrow AS, et al. JAMA. 2020;323:455-65. Read More

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http://dx.doi.org/10.7326/ACPJ202006160-064DOI Listing

A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure.

Crit Care 2020 06 12;24(1):337. Epub 2020 Jun 12.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Penn State Health, Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.

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http://dx.doi.org/10.1186/s13054-020-03063-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291186PMC

Non-invasive ventilation in the treatment of early hypoxemic respiratory failure caused by COVID-19: considering nasal CPAP as the first choice.

Crit Care 2020 06 11;24(1):333. Epub 2020 Jun 11.

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen Institute of Respiratory Diseases, 1017 Dong Men Road, Shenzhen, 518020, China.

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http://dx.doi.org/10.1186/s13054-020-03054-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289232PMC

Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 10;21(1):513. Epub 2020 Jun 10.

Section of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital University of Copenhagen, Hellerup, Denmark.

Objectives: The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and pre-emptive treatment of supra-infections can shorten hospitalisation duration for patients with COVID-19 (measured as "days alive and out of hospital" as the primary outcome), reduce the risk of non- invasive ventilation, treatment in the intensive care unit and death.

Trial Design: This is a multi-centre, randomised, Placebo-controlled, 2-arm ratio 1:1, parallel group double-blind study.

Participants: 226 participants are recruited at the trial sites/hospitals, where the study will take place in Denmark: Aalborg, Bispebjerg, Gentofte, Herlev, Hillerød, Hvidovre, Odense and Slagelse hospitals. Read More

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http://dx.doi.org/10.1186/s13063-020-04409-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284668PMC
June 2020
2.117 Impact Factor

Non-invasive ventilation indication for critically ill cancer patients admitted to the intensive care unit for acute respiratory failure (ARF) with associated cardiac dysfunction: Results from an observational study.

PLoS One 2020 10;15(6):e0234495. Epub 2020 Jun 10.

Polyvalent Intensive Care Unit, Department of Anesthesiology and Critical Care, Institut Paoli Calmettes, Marseille, France.

Background: Acute respiratory failure (ARF) is a life-threatening complication in onco-hematology patients. Optimal ventilation strategy in immunocompromised patients has been highly controversial over the last decade. Data are lacking on patients presenting with ARF associating isolated cardiac dysfunction or in combination with another etiology. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234495PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286506PMC

Helmet-based noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease: A case report.

World J Clin Cases 2020 May;8(10):1939-1943

Division of Pulmonology, Department of Internal Medicine, Inha University Hospital, Incheon 22332, South Korea.

Background: Noninvasive ventilation (NIV) reduces intubation rates, mortalities, and lengths of hospital and intensive care unit stays in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Helmet-based NIV is better tolerated than oronasal mask-based ventilation, and thus, allows NIV to be conducted for prolonged periods at higher pressures with minimal air leaks.

Case Summary: A 73-year-old man with a previous diagnosis of COPD stage 4 was admitted to our medical intensive care unit with chief complaints of cough, sputum, and dyspnea of several days' duration. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i10.1939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262703PMC

High flow nasal cannula oxygen therapy in adults with COVID-19 respiratory failure. A case report.

Monaldi Arch Chest Dis 2020 Jun 9;90(2). Epub 2020 Jun 9.

Internal Medicine Department, University Hospital of Patras, Rion.

The novel corona virus (SARS-CoV-2) continuous to spread around the globe causing high mortality, tremendous stress on healthcare systems and an unprecedented disruption of everyday life with unpredictable socioeconomic ramifications. The diseaseis typically affecting the respiratory system and some patients will develop refractory hypoxemic respiratory insufficiency requiring mechanical ventilation. The role of non-invasive ventilation (NIV), high flow nasal cannula (HFNC) or continuous positive airway pressure devices (C-PAP) in the treatment of the 2019 corona virus disease (COVID-19) is not yet clear. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1323DOI Listing

Weaning from Non-Invasive Ventilation and High Flow Nasal Cannula in bronchiolitis: a survey of practice.

Pediatr Pulmonol 2020 Jun 8. Epub 2020 Jun 8.

Pediatric Intensive Care Unit, University Hospital of Grenoble-Alpes, La Tronche, France.

Rational: This study aims to describe the current weaning practices from any type of noninvasive support in infants with bronchiolitis, in terms of weaning procedures, weaning initiation and weaning failure criteria.

Working Hypothesis: No information regarding the weaning practices is currently available and there may be a wide variability of strategies.

Study Design: A cross-sectional electronic survey. Read More

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http://dx.doi.org/10.1002/ppul.24890DOI Listing

Non-Invasive Ventilatory Support In the Elderly.

Curr Geriatr Rep 2019 Sep 13;8(3):153-159. Epub 2019 Jun 13.

Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, Mail Location 0558, Cincinnati, Ohio 45267-0558.

Purpose Of Review: The first description of non-invasive ventilation use began in the 1920s. Since then, its role in patient care has evolved through increased clinical knowledge and scientific advancements. The utilization of non-invasive ventilation has broadened from initial application in acute in-hospital ICU settings to now include the outpatient settings. Read More

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http://dx.doi.org/10.1007/s13670-019-00287-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274080PMC
September 2019

Long-term outcome with focus on pulmonary hypertension in Obesity Hypoventilation Syndrome.

Clin Respir J 2020 Jun 7. Epub 2020 Jun 7.

Centre for Pneumology, Donaustauf Hospital, Donaustauf, Germany.

Introduction: Pulmonary Hypertension (PH) is a frequent comorbidity in Obesity Hypoventilation Syndrome (OHS).

Objective: We investigated long-term outcome of OHS with a particular emphasis on PH.

Methods: In a prospective design, 64 patients with OHS and established noninvasive positive pressure ventilation (NPPV), were assessed by serum biomarkers, right heart catheterization, blood gases analysis, lung function, Epworth-Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), World Health Organization-functional class (WHO-FC) and health-related quality of life (HRQL) via the Severe Respiratory Insufficiency (SRI) questionnaire. Read More

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http://dx.doi.org/10.1111/crj.13225DOI Listing

A snapshot of the Covid-19 pandemic among pregnant women in France.

J Gynecol Obstet Hum Reprod 2020 Jun 4:101826. Epub 2020 Jun 4.

Assistance Publique-Hôpitaux de Paris, 75004, Paris, France.

Objective: To describe the course over time of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in French women from the beginning of the pandemic until mid-April, the risk profile of women with respiratory complications, and short-term pregnancy outcomes.

Methods: We collected a case series of pregnant women with COVID-19 in a research network of 33 French maternity units between March 1 and April 14, 2020. All cases of SARS-CoV-2 infection confirmed by a positive result on real-time reverse transcriptase polymerase chain reaction tests of a nasal sample and/or diagnosed by a computed tomography chest scan were included and analyzed. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270811PMC

Recent Advances in the Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

Med Clin North Am 2020 Jul;104(4):615-630

Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1232, New York, NY 10029, USA.

Chronic obstructive pulmonary disease is a chronic, irreversible obstructive lung disease that results from exposure to noxious stimuli. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) usually result from viral or bacterial respiratory infections, but may also result from exposure to environmental pollution. AECOPD are associated with functional decline, increased risk of subsequent exacerbations, and death. Read More

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http://dx.doi.org/10.1016/j.mcna.2020.02.003DOI Listing

Noninvasive Positive Pressure Ventilation for Acute Decompensated Heart Failure.

Authors:
Michinari Hieda

Heart Fail Clin 2020 Jul;16(3):271-282

University of Texas Southwestern Medical Center, Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Avenue, Dallas, TX 75231, USA; Kyushu University, School of Medicine, Department of Medicine and Biosystemic Science, Division of Cardiology, 3-1-1 Maidashi Higashi-ku Fukuoka City, Clinical Research Building B6F Fukuoka, Zip:812-8582, Japan. Electronic address:

Noninvasive positive pressure ventilation (NIPPV), which can be applied without endotracheal airway or tracheostomy, has been used as the first-line device for patients with acute decompensated heart failure (ADHF) and cardiogenic pulmonary edema. Positive airway pressure (PAP) devices include continuous PAP, bilevel PAP, and adaptive servoventilation. NIPPV can provide favorable physiologic benefits, including improving oxygenation, respiratory mechanics, and pulmonary and systemic hemodynamics. Read More

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http://dx.doi.org/10.1016/j.hfc.2020.02.005DOI Listing

Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-analysis.

JAMA 2020 Jun 4. Epub 2020 Jun 4.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.

Importance: Treatment with noninvasive oxygenation strategies such as noninvasive ventilation and high-flow nasal oxygen may be more effective than standard oxygen therapy alone in patients with acute hypoxemic respiratory failure.

Objective: To compare the association of noninvasive oxygenation strategies with mortality and endotracheal intubation in adults with acute hypoxemic respiratory failure.

Data Sources: The following bibliographic databases were searched from inception until April 2020: MEDLINE, Embase, PubMed, Cochrane Central Register of Controlled Trials, CINAHL, Web of Science, and LILACS. Read More

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http://dx.doi.org/10.1001/jama.2020.9524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273316PMC

Recovery from hypoxemia and Hypercapnia following noninvasive pressure support ventilation in a patient with statin-associated necrotizing myopathy: a case report.

BMC Pulm Med 2020 Jun 3;20(1):156. Epub 2020 Jun 3.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.

Background: Statin-associated necrotizing myopathy (SANM) is a rare autoimmune disorder caused by administration of statins. SANM is characterized by weakness due to necrosis and regeneration of myofibers. Here we report the first case of SANM with acute respiratory failure treated with noninvasive pressure support ventilation in addition to immunosuppressants. Read More

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http://dx.doi.org/10.1186/s12890-020-01195-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268346PMC

Effects of assist parameter on the performance of proportional assist ventilation in a lung model of chronic obstructive pulmonary disease.

Respir Med Res 2020 May 15;78:100766. Epub 2020 May 15.

Department of respiratory medicine, Shanghai The First People's hospital, Shanghai Jiao Tong university, 200080 Shanghai, China.

Background: How the assist parameters affect synchronization and inspiratory workload in proportional assist ventilation (PAV) remains unknown.

Purpose: This bench study aimed to optimize the PAV parameters by evaluating their effects on patient-ventilator synchrony and work of breathing (WOB) in a chronic obstructive pulmonary disease (COPD) model during noninvasive ventilation, compared with the pressure support ventilation (PSV) mode.

Methods: The Respironics V60 ventilator was connected to an ASL5000 lung simulator, which simulates lung mechanics in COPD (compliance, 50mL/cmHO; expiratory resistance, 20 cmHO/L/s; respiratory rate, 15 breaths/min; inspiratory time, 1. Read More

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http://dx.doi.org/10.1016/j.resmer.2020.100766DOI Listing

Noninvasive Ventilation for Respiratory Failure: Impact of Ventilator Settings Adjustments.

Am J Respir Crit Care Med 2020 Jun 3. Epub 2020 Jun 3.

Assistance Publique-Hôpitaux de Paris, CHU Henri Mondor, Service de réanimation médicale, Créteil, France.

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http://dx.doi.org/10.1164/rccm.202005-1565LEDOI Listing

Measuring the efficiency of pulmonary gas exchange using expired gas instead of arterial blood: Comparing the "ideal" PO2 of Riley with end-tidal PO2.

Am J Physiol Lung Cell Mol Physiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Medicine and Radiology, University of California, San Diego, United States.

When using a new noninvasive method for measuring the efficiency of pulmonary gas exchange, a key measurement is the oxygen deficit, defined as the difference between the end-tidal alveolar PO2 and the calculated arterial PO2. The end-tidal PO2 is measured using a rapid gas analyzer, and the arterial PO2 is derived from pulse oximetry after allowing for the effect of the PCO2 on the oxygen affinity of hemoglobin. In the present report we show that the values of end-tidal PO2 and PCO2 are highly reproducible providing a solid foundation for the measurement of the oxygen deficit. Read More

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http://dx.doi.org/10.1152/ajplung.00150.2020DOI Listing

Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment.

Rev Soc Bras Med Trop 2020 1;53:e20200227. Epub 2020 Jun 1.

The Affiliated Hospital of Guiyang, Guizhou Medical University, China.

The novel coronavirus pneumonia (NCP) outbreak occurred in Wuhan, China at the end of 2019. Here, we report the clinical characteristics and therapeutic procedure for a case of severe NCP. The patient was started on glucocorticoids and non-invasive ventilator treatment. Read More

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http://dx.doi.org/10.1590/0037-8682-0227-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269524PMC
June 2020
0.942 Impact Factor