694 results match your criteria Nongonococcal Infectious Arthritis


Haemophilus Species Isolated in Urethral Exudates as a Possible Causative Agent in Acute Urethritis: A Study of 38 Cases.

Actas Dermosifiliogr 2018 Oct 31. Epub 2018 Oct 31.

Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.

Introduction: The incidence of urethritis due to Haemophilus species is increasing. The main aim of this study was to describe the clinical and microbiological characteristics of patients with this form of urethritis. A secondary aim was to discuss the adequacy of treatments in patients with different types of antibiotic resistance. Read More

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October 2018
1 Read

Management of Urethritis: Is It Still the Time for Empirical Antibiotic Treatments?

Eur Urol Focus 2018 Oct 11. Epub 2018 Oct 11.

Alta Uro AG, Merian Iselin Klinik, Center of Biomechanics & Calorimetry (COB), University of Basel, Basel, Switzerland.

Context: Urethritis prevalence in Europe changed in the last years due to both the increase of migratory streams from North Africa and the more frequent exposition of males to relevant risk factors. Owing to these reasons, urethritis treatment should be optimized by accurate microbiological investigations to avoid the risk of persistence, recurrence, or reinfection.

Objective: The aim of this systematic review is to optimize the treatments for urethritis and investigate the applicability of nucleic acid amplification test (NAAT) as the primary microbiological investigation. Read More

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October 2018

Long duration of asymptomatic Mycoplasma genitalium infection after syndromic treatment for nongonococcal urethritis.

Clin Infect Dis 2018 Oct 3. Epub 2018 Oct 3.

Epidemiology, University of Washington, Seattle, Washington, USA.

Background: Although Mycoplasma genitalium (MG) is an acknowledged cause of nongonococcal urethritis (NGU), access to diagnostic testing is limited. Syndromic management is common, yet little is known about natural history.

Methods: Between August 8, 2014-April 15, 2016 a case series of 13 heterosexual men ≥16 years with MG was identified within a cohort study of men with and without NGU attending an urban Sexually Transmitted Diseases Clinic. Read More

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October 2018
5 Reads

Microscopy of Gram-stained urethral smear in the diagnosis of urethritis: Which threshold value should be selected?

Andrologia 2018 Dec 20;50(10):e13143. Epub 2018 Sep 20.

Department of Urology, Gözde Hospital, Malatya, Turkey.

The aim of this study was to investigate the sensitivity of GSS in the diagnosis of urethritis in patients who present to the outpatient clinic with symptoms of urethritis. Sixty-three male patients who presented to our outpatient clinic with symptoms of urethritis between January and March 2018 were evaluated. Urethral smear samples obtained from patients were evaluated both by GSS examination and by Real-time Multiplex Polymerase Chain Reaction (rt-MPCR) assay. Read More

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December 2018
3 Reads

Primary Syphilis in the Male Urethra - A Case Report.

Clin Infect Dis 2018 Sep 10. Epub 2018 Sep 10.

Department of Epidemiology, University of Washington, Seattle, Washington, United States.

A man with nongonococcal urethritis had negative syphilis serology. We documented urethral Treponema pallidum infection using broad-range bacterial polymerase-chain-reaction and sequencing, targeted polymerase-chain-reaction, and immunofluorescence microscopy. The patient subsequently seroconverted for syphilis; symptoms resolved with penicillin. Read More

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September 2018
3 Reads

A clinico-etiological study of urethritis in men attending sexually transmitted disease clinic at a tertiary hospital.

Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):136-141

Department of Dermatology, Venereology and Leprology, Bengaluru Medical College and Research Institute, Bengaluru, Karnataka, India.

Introduction: Urethritis is an important sexually transmitted infection in the present day. Causative agents are many for urethritis, ranging from bacteria, virus, to protozoa.

Aim: The aim was to study the various etiological agents and clinical presentation of men with urethritis. Read More

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August 2018
5 Reads

The Role of Polymorphonuclear Leukocyte Counts from Urethra, Cervix, and Vaginal Wet Mount in Diagnosis of Nongonococcal Lower Genital Tract Infection.

Infect Dis Obstet Gynecol 2018 26;2018:8236575. Epub 2018 Jul 26.

Oslo University Hospital, Department of Venereology, The Olafia Clinic, Norwegian National Advisory Unit on Sexually Transmitted Infections, Oslo, Norway.

Objective: The aim of this study was to evaluate whether the polymorphonuclear leukocyte (PMNL) inflammatory response in women with nongonococcal lower genital tract infection (LGTI) can be used to optimize criteria for syndromic treatment.

Methods: A cross-sectional study of 375 women attending the STI clinic in Oslo. Urethral, cervical, and vaginal specimens underwent microscopy for PMNLs. Read More

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July 2018
4 Reads

Use of Pristinamycin for Macrolide-Resistant Mycoplasma genitalium Infection.

Emerg Infect Dis 2018 02;24(2):328-335

High levels of macrolide resistance and increasing fluoroquinolone resistance are found in Mycoplasma genitalium in many countries. We evaluated pristinamycin for macrolide-resistant M. genitalium in a sexual health center in Australia. Read More

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February 2018
16 Reads

Mycoplasma genitalium Infection in Men.

J Infect Dis 2017 Jul;216(suppl_2):S396-S405

Department of Epidemiology, Tulane University School of Public Health.

Mycoplasmagenitalium is one of the major causes of nongonococcal urethritis (NGU) worldwide but an uncommon sexually transmitted infection (STI) in the general population. The risk of sexual transmission is probably lower than for Chlamydia trachomatis. Infection in men is usually asymptomatic and it is likely that most men resolve infection without developing disease. Read More

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July 2017
4 Reads

Mycoplasma genitalium: Accurate Diagnosis Is Necessary for Adequate Treatment.

J Infect Dis 2017 Jul;216(suppl_2):S406-S411

Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland.

Background: Mycoplasma genitalium is very difficult to grow in culture but has been more able to be studied for disease associations since the advent of research molecular amplification assays. Polymerase chain reaction (PCR) and other molecular assays have demonstrated an association with adverse disease outcomes, such as urethritis or nongonococcal urethritis in men and adverse reproductive sequelae in women-for example, cervicitis, endometritis, and pelvic inflammatory disease (PID), including an association with risk for human immunodeficiency virus. The lack of commercially available diagnostic assays has limited widespread routine testing. Read More

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July 2017
10 Reads

Mycoplasma genitalium Macrolide and Fluoroquinolone Resistance: Prevalence and Risk Factors Among a 2013-2014 Cohort of Patients in Barcelona, Spain.

Sex Transm Dis 2017 08;44(8):457-462

From the *Sexually Transmitted Infections Unit Vall d'Hebron-Drassanes, Vall d'Hebron Hospital, University of Barcelona, Barcelona, Spain; †Microbiology Department, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain; and ‡Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.

Background: Macrolide and fluoroquinolone resistance is alarmingly emerging in M. genitalium worldwide. This article provides the first estimates of the current prevalence of macrolide and fluoroquinolone resistance-mediating mutations in Barcelona, Spain, and identifies risk factors associated with the acquisition of these resistances. Read More

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August 2017
1 Read

Meatal Swabs Contain Less Cellular Material and Are Associated with a Decrease in Gram Stain Smear Quality Compared to Urethral Swabs in Men.

J Clin Microbiol 2017 07 10;55(7):2249-2254. Epub 2017 May 10.

Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.

Urethral swabs are the samples of choice for point-of-care Gram stain testing to diagnose infection and nongonococcal urethritis (NGU) in men. As an alternative to urethral swabs, meatal swabs have been recommended for the collection of urethral discharge to diagnose and infection in certain populations by nucleic acid amplification testing (NAAT), as they involve a less invasive collection method. However, as meatal swabs could be sampling a reduced surface area and result in fewer collected epithelial cells compared to urethral swabs, the adequacy of meatal swab specimens to collect sufficient cellular material for Gram stain testing remains unknown. Read More

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July 2017
5 Reads

Treatment outcomes and loss to follow-up rate of male patients with gonococcal and nongonococcal urethritis who attended the sexually transmitted disease clinic: An 8-year retrospective study.

Indian J Sex Transm Dis AIDS 2017 Jan-Jun;38(1):37-42

Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Background: Poor follow-up compliance of patients with infectious urethritis is a recognized and serious public health problem in Thailand.

Aim: The aim of this study was to determine treatment outcomes and loss to follow-up rate of male patients with gonococcal urethritis (GU) and non-GU (NGU) at a sexually transmitted disease (STD) clinic at Thailand's tertiary hospital.

Methods: This retrospective chart review of male patients who sought treatment at STDs Clinic, Siriraj Hospital, and who were diagnosed with GU and/or NGU was conducted during January 2007 to December 2014 study period. Read More

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April 2017
21 Reads

Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities.

Sex Transm Dis 2017 04;44(4):205-210

From the *iClinic, 5-9-6 Nagamachi, Taihaku-ku, Sendai, Miyagi; †Department of Urology, Graduate School of Medicine, Gifu University, Gifu City, Gifu; and ‡Department of Bacteriology I, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.

Background: There have been few comprehensive studies on Haemophilus influenza-positive urethritis.

Methods: In this retrospective study, we enrolled 68 men with H. influenzae-positive urethritis, including coinfections with Neisseria gonorrhoeae, Chlamydia trachomatis, and/or genital mycoplasmas: 2, 3, 20, and 43 treated with ceftriaxone, levofloxacin, sitafloxacin, and extended-release azithromycin (azithromycin-SR), respectively. Read More

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April 2017
3 Reads

The Diagnosis of Nongonococcal Urethritis in Men: Can There Be a Universal Standard?

Sex Transm Dis 2017 03;44(3):195-196

From the *Denver STD Prevention Training Center, Denver Public Health Department, Denver Health and Hospital, Denver, CO; †Community and Behavioral Health, Colorado School of Public Health, University of Colorado, Denver; and ‡Public Health Informatics, Denver Public Health, Department Denver Health and Hospital, Denver, CO.

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Neisseria meningitidis ST11 Complex Isolates Associated with Nongonococcal Urethritis, Indiana, USA, 2015-2016.

Emerg Infect Dis 2017 02;23(2):336-339

At a clinic in Indianapolis, Indiana, USA, we observed an increase in Neisseria gonorrhoeae-negative men with suspected gonococcal urethritis who had urethral cultures positive for N. meningitidis. We describe genomes of 2 of these N. Read More

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February 2017
1 Read

Management of Herpetic Urethritis and Female Partners of Men With Nongonococcal Urethritis.

Authors:
H Handsfield

Sex Transm Dis 2017 02;44(2):131-133

From the Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA.

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February 2017

A Case of Rectal Ureaplasma Infection and Implications for Testing in Young Men Who Have Sex with Men: The P18 Cohort Study.

LGBT Health 2017 04 27;4(2):161-163. Epub 2016 Dec 27.

3 Center for Health, Identity, Behavior and Prevention Studies, New York University , New York, New York.

Ureaplasma is a significant cause of nongonococcal urethritis. This is a case of rectal Ureaplasma found on culture in a young man who has sex with men not previously reported in the literature. Nucleic acid amplification tests are now standard of care for sexually transmitted infection testing, but they do not test for Ureaplasma and, therefore, may be missing important infections. Read More

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April 2017
1 Read

Azithromycin 1.5g Over 5 Days Compared to 1g Single Dose in Urethral Mycoplasma genitalium: Impact on Treatment Outcome and Resistance.

Clin Infect Dis 2017 Feb 24;64(3):250-256. Epub 2016 Oct 24.

Central Clinical School, Monash University, and.

Background: We evaluated the impact of extended azithromycin (1.5g over 5 days) on selection of macrolide resistance and microbiological cure in men with Mycoplasma genitalium urethritis during 2013-2015 and compared this to cases treated with azithromycin 1g in 2012-2013.

Methods: Microbiological cure was determined for men with M. Read More

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February 2017
33 Reads

Acute Cystitis Caused by Commensal Neisseria oralis: A Case Report and Review of the Literature.

Infect Disord Drug Targets 2017 ;17(1):64-66

Department of Infectious Diseases, Christchurch Public Hospital, Christchurch. New Zealand.

Background: Neisseria are usually harmless inhabitants of otherwise asymptomatic persons' upper respiratory mucosal surfaces.

Method: It is, therefore, expected that a disturbance in the physiology leads to nongonococcal, non-meningococcal Neisseria becoming pathogenic.

Result: We report the case of a diabetic man who initially presented with nonspecific symptoms and was later found to have cystitis caused by N. Read More

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June 2018
5 Reads

Determinants of Behavior Change Intention Among Heterosexual Thai Males Diagnosed with Sexually Transmitted Diseases.

AIDS Patient Care STDS 2016 11;30(11):512-518

2 Bangrak STIs Cluster, Bureau of AIDS, TB, and STIs, Ministry of Public Health , Sathorn, Bangkok, Thailand .

This study sought to identify factors associated with intention to change sexual practices among heterosexual Thai males diagnosed with sexually transmitted infections (STIs). STI clinic patients (n = 247) reported their sexual behaviors and condom use during the previous 3 months. STI and HIV knowledge, motivation to change sexual practices, and behavioral skills were assessed. Read More

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November 2016
4 Reads

Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis.

Sex Transm Dis 2016 10;43(10):599-602

From the *Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; †Department of Epidemiology, ‡Department of Global Health, University of Washington, Seattle, WA; §Department of Medicine, University of Alabama at Birmingham, Birmingham, AL; ∥Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA; and ¶Department of Medicine, University of Mississippi Medical Center, Jackson, MS.

Background: Three recent prospective studies have suggested that the 1-g dose of azithromycin for Chlamydia trachomatis (Ct) was less effective than expected, reporting a wide range of treatment failure rates (5.8%-22.6%). Read More

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October 2016
4 Reads

Sexually transmitted infections case notification rates in the Kingdom of Saudi Arabia, 2005-2012.

J Infect Dev Ctries 2016 Aug 31;10(8):884-7. Epub 2016 Aug 31.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Introduction: Sexually transmitted infections (STIs) are major public health concerns around the world. This study describes the epidemiology of reported STI cases from 2005 to 2012 in the Kingdom of Saudi Arabia.

Methodology: The annual registry was the main source of data as reported by healthcare providers. Read More

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August 2016
10 Reads

Prevalence of Urogenital Mycoplasmas Among Men with NGU in Upper Silesia, Poland. Preliminary Study.

Pol J Microbiol 2016 ;65(1):93-5

The prevalence of urogenital mycoplasmas in men with NGU in Upper Silesia (Poland) was studied. Mycoplasmas were detected in 36.7% men (Ureaplasma parvum and Mycoplasma genitalium were found in 30% and 16. Read More

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July 2016
6 Reads

Chronic Cervicitis: Presenting Features and Response to Therapy.

J Low Genit Tract Dis 2016 Jul;20(3):e30-3

Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

Objectives: Chronic nongonococcal nonchlamydial cervicitis is a condition of unknown etiology. Data about treatment options are limited. Our goal was to review a single center's experience in managing women with chronic NGNCC. Read More

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July 2016
12 Reads

Multiplex Real-Time PCR Assay with High-Resolution Melting Analysis for Characterization of Antimicrobial Resistance in Neisseria gonorrhoeae.

J Clin Microbiol 2016 08 25;54(8):2074-81. Epub 2016 May 25.

Institute for Infectious Diseases, University of Bern, Bern, Switzerland

Resistance to antibiotics used against Neisseria gonorrhoeae infections is a major public health concern. Antimicrobial resistance (AMR) testing relies on time-consuming culture-based methods. Development of rapid molecular tests for detection of AMR determinants could provide valuable tools for surveillance and epidemiological studies and for informing individual case management. Read More

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August 2016
9 Reads

Mycoplasma genitalium: An Overlooked Sexually Transmitted Pathogen in Women?

Infect Dis Obstet Gynecol 2016 24;2016:4513089. Epub 2016 Apr 24.

Department of Obstetrics and Gynecology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

Mycoplasma genitalium is a facultative anaerobic organism and a recognized cause of nongonococcal urethritis in men. In women, M. genitalium has been associated with cervicitis, endometritis, pelvic inflammatory disease (PID), infertility, susceptibility to human immunodeficiency virus (HIV), and adverse birth outcomes, indicating a consistent relationship with female genital tract pathology. Read More

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October 2016
10 Reads

Sexual Assault and Sexually Transmitted Infections in Adults, Adolescents, and Children.

Clin Infect Dis 2015 Dec;61 Suppl 8:S856-64

Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn.

Survivors of sexual assault are at risk for acquiring sexually transmitted infections (STIs). We conducted literature reviews and invited experts to assist in updating the sexual assault section for the 2015 Centers for Disease Control and Prevention sexually transmitted diseases (STD) treatment guidelines. New recommendations for STI management among adult and adolescent sexual assault survivors include use of nucleic acid amplification tests (NAATs) for detection of Trichomonas vaginalis by vaginal swabs; NAATs for detection of Neisseria gonorrhoeae and Chlamydia trachomatis from pharyngeal and rectal specimens among patients with a history of exposure or suspected extragenital contact after sexual assault; empiric therapy for gonorrhea, chlamydia, and trichomoniasis based on updated treatment regimens; vaccinations for human papillomavirus (HPV) among previously unvaccinated patients aged 9-26 years; and consideration for human immunodeficiency virus (HIV) nonoccupational postexposure prophylaxis using an algorithm to assess the timing and characteristics of the exposure. Read More

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December 2015
5 Reads

Efficacy of Antimicrobial Therapy for Mycoplasma genitalium Infections.

Clin Infect Dis 2015 Dec;61 Suppl 8:S802-17

Division of Infectious Diseases, Louisiana State University, New Orleans.

Mycoplasma genitalium has been causally linked with nongonococcal urethritis in men and cervicitis, pelvic inflammatory disease, preterm birth, spontaneous abortion, and infertility in women, yet treatment has proven challenging. To inform treatment recommendations, we reviewed English-language studies describing antimicrobial susceptibility, resistance-associated mutations, and clinical efficacy of antibiotic therapy, identified via a systematic search of PubMed supplemented by expert referral. Minimum inhibitory concentrations (MICs) from some contemporary isolates exhibited high-level susceptibility to most macrolides and quinolones, and moderate susceptibility to most tetracyclines, whereas other contemporary isolates had high MICs to the same antibiotics. Read More

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December 2015
11 Reads

Pattern of sexually transmitted infections in a Muslim majority region of North India.

Indian J Sex Transm Dis AIDS 2015 Jan-Jun;36(1):30-4

Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College, University of Kashmir, Srinagar, Jammu and Kashmir, India.

Background: Changing trends of sexually transmitted infections (STI) and HIV/AIDS has been noted in the literature over years, depending to some extent on the geographical and cultural factors of the region. In Kashmir Valley also, the pattern of STI may be different from the rest of the country.

Aims Of The Study: The aim was to present the experience with patterns of STI in Kashmir. Read More

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September 2015
13 Reads

The Efficacy of Azithromycin for the Treatment of Genital Mycoplasma genitalium: A Systematic Review and Meta-analysis.

Clin Infect Dis 2015 Nov 3;61(9):1389-99. Epub 2015 Aug 3.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton.

Background: Mycoplasma genitalium (MG) is associated with nongonococcal urethritis in men and cervicitis in women. Current guidelines recommend treatment with 1 gram of azithromycin; however, treatment failure has increasingly been reported. This meta-analysis estimates treatment efficacy following treatment with 1 gram of azithromycin. Read More

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November 2015
13 Reads

Complete Genome Sequence of Mycoplasma hominis Strain Sprott (ATCC 33131), Isolated from a Patient with Nongonococcal Urethritis.

Genome Announc 2015 Jul 9;3(4). Epub 2015 Jul 9.

Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.

Presented here is the complete and annotated genome sequence of Mycoplasma hominis Sprott (ATCC 33131). The chromosome comprises 695,214 bp, which is approximately 30 kb larger than the syntenic genome of M. hominis PG21(T). Read More

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Loop-mediated isothermal amplification (LAMP) for the rapid detection of Mycoplasma genitalium.

Diagn Microbiol Infect Dis 2015 Sep 27;83(1):13-7. Epub 2015 May 27.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom. Electronic address:

Mycoplasma genitalium is a sexually transmissible, pathogenic bacterium and a significant cause of nongonococcal urethritis in both men and women. Due to the difficulty of the culture of M. genitalium from clinical samples, the laboratory diagnosis of M. Read More

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September 2015
2 Reads

Detection of Mycoplasma genitalium from male primary urine specimens: an epidemiologic dichotomy with Trichomonas vaginalis.

Diagn Microbiol Infect Dis 2015 Jul 25;82(3):194-8. Epub 2015 Mar 25.

Wheaton Franciscan Laboratory, Milwaukee, WI, USA, 53215.

A total of 2750 male urines subjected to a transcription-mediated amplification (TMA)-based Mycoplasma genitalium assay yielded 188 positive results (6.84%). This rate was similar to Chlamydia trachomatis (6. Read More

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July 2015
15 Reads

Molecular Assay for Detection of Genetic Markers Associated with Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae.

J Clin Microbiol 2015 Jul 15;53(7):2042-8. Epub 2015 Apr 15.

Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

The incidence of antimicrobial-resistant Neisseria gonorrhoeae continues to rise in Canada; however, antimicrobial resistance data are lacking for approximately 70% of gonorrhea infections that are diagnosed directly from clinical specimens by nucleic acid amplification tests (NAATs). We developed a molecular assay for surveillance use to detect mutations in genes associated with decreased susceptibility to cephalosporins that can be applied to both culture isolates and clinical samples. Real-time PCR assays were developed to detect single nucleotide polymorphisms (SNPs) in ponA, mtrR, penA, porB, and one N. Read More

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July 2015
3 Reads

In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.

Antimicrob Agents Chemother 2015 Apr 2;59(4):2358-64. Epub 2015 Feb 2.

Department of Developmental Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi City, Osaka, Japan

Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited. Read More

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April 2015
7 Reads

Are Ureaplasma spp. a cause of nongonococcal urethritis? A systematic review and meta-analysis.

PLoS One 2014 2;9(12):e113771. Epub 2014 Dec 2.

Division of Clinical Microbiology, School of Laboratory Medicine, Tianjin Medical University, Tianjin, China.

Background: Nongonococcal urethritis (NGU) is the most common male reproductive tract syndrome. Ureaplasmas spp. including U. Read More

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July 2015
6 Reads

Prevalence of Trichomonas vaginalis by PCR in men attending a primary care urology clinic in South Korea.

Korean J Parasitol 2014 Oct 22;52(5):551-5. Epub 2014 Oct 22.

Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine, Daegu 700-422, Korea.

Trichomonas vaginalis, a causative agent of trichomoniasis, may trigger symptomatic or asymptomatic nongonococcal urethritis and chronic prostatitis in men. Despite the availability of highly sensitive diagnostic tests, such as nucleic acid amplification tests, including PCR, few prospective studies present data on male T. vaginalis infection in South Korea. Read More

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October 2014
3 Reads

Characteristics of acute nongonococcal urethritis in men differ by sexual preference.

J Clin Microbiol 2014 Aug 4;52(8):2971-6. Epub 2014 Jun 4.

Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia Central Clinical School, Monash University, Clayton, Victoria, Australia

Nongonococcal urethritis (NGU) is a common clinical syndrome, but no etiological agent is identified in a significant proportion of cases. Whether the spectrum of pathogens differs between heterosexual men (MSW) and men who have sex with men (MSM) is largely unstudied but of considerable clinical relevance. A retrospective review was done using the electronic medical record database of Melbourne Sexual Health Centre, Australia. Read More

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August 2014
3 Reads

Azithromycin.

Profiles Drug Subst Excip Relat Methodol 2014 ;39:1-40

Research Center, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Azithromycin is an azalide, a subclass of macrolide antibiotics. It is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making the lactone ring 15-membered. It prevents bacteria from growing by interfering with their protein synthesis. Read More

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September 2014
4 Reads
2 Citations

Mycoplasma genitalium testing pattern and macrolide resistance: a Danish nationwide retrospective survey.

Clin Infect Dis 2014 Jul 11;59(1):24-30. Epub 2014 Apr 11.

Microbiology and Infection Control, Sexually Transmitted Infections, Research and Development, Statens Serum Institut, Copenhagen, Denmark.

Background: Mycoplasma genitalium is a common cause of nongonococcal urethritis (NGU) and cervicitis. The aim of the study was to analyze the M. genitalium testing pattern and distribution of positive results according to sex and age in a 5-year period where all diagnostic M. Read More

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July 2014
1 Read

Associated factors with and genotypes of Chlamydia trachomatis infection among clients seeking voluntary counseling and testing for HIV infection in Taiwan.

J Microbiol Immunol Infect 2014 Dec 31;47(6):526-32. Epub 2013 Dec 31.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan. Electronic address:

Background/purpose: This study aimed to investigate the factors associated with Chlamydia trachomatis infection and the genotype distribution of the strains among the clients seeking voluntary counseling and testing (VCT) for human immunodeficiency virus (HIV) in Taiwan.

Methods: The VCT clients completed an anonymous self-administered questionnaire interview to inquire into the risks for sexually transmitted diseases, followed by providing a 10-mL first-catch urine specimen to detect C. trachomatis with the use of polymerase-chain-reaction assays. Read More

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December 2014
3 Reads

Clinical Efficacy of a Single Two Gram Dose of Azithromycin Extended Release for Male Patients with Urethritis.

Antibiotics (Basel) 2014 Apr 2;3(2):109-20. Epub 2014 Apr 2.

Department of Urology, Fuji City General Hospital, 50 Takashima-Cho, Fuji, Shizuoka 4178567, Japan.

To clarify the clinical efficacy of a single oral 2 g dose of azithromycin extended-release for heterosexual male patients with urethritis, and the current antimicrobial sensitivity of Neisseria gonorrhoeae to azithromycin, a prospective clinical trial was conducted from 2011-2013. In patients with gonococcal urethritis, the eradication rate was 90.9% (30 of 33). Read More

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April 2014
14 Reads

Time to manage Mycoplasma genitalium as an STI: but not with azithromycin 1 g!

Curr Opin Infect Dis 2014 Feb;27(1):68-74

aSchool of Social and Community Medicine, University of Bristol, UK bBristol Sexual Health Centre, University Hospitals Bristol NHS Foundation Trust, Tower Hill, Bristol cAquarius Population Health, London, UK.

Purpose Of Review: Mycoplasma genitalium is a sexually transmitted infection that causes significant morbidity in men and women and is a co-factor in HIV transmission. However, commercial diagnostic tests are not generally available for M. genitalium and sub-optimal treatment is often given. Read More

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February 2014
2 Reads

High prevalence of antibiotic-resistant Mycoplasma genitalium in nongonococcal urethritis: the need for routine testing and the inadequacy of current treatment options.

Clin Infect Dis 2014 Mar 26;58(5):631-7. Epub 2013 Nov 26.

Centre for Infection and Immunity, St George's University of London.

Background:  Empirical antibiotic therapy for nongonococcal urethritis (NGU) and cervicitis is aimed at Chlamydia trachomatis, but Mycoplasma genitalium, which also commonly causes undiagnosed NGU, necessitates treatment with macrolides or fluoroquinolones rather than doxycycline, the preferred chlamydia treatment. Prevalence of M. genitalium and associated genotypic markers of macrolide and fluoroquinolone resistance among men symptomatic of urethritis were investigated. Read More

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March 2014
16 Reads

Corynebacterium propinquum associated with acute, nongonococcal urethritis.

Sex Transm Dis 2013 Oct;40(10):829-31

From the *Department of Medical Microbiology, Charing Cross Hospital, Imperial College Healthcare National Health Service Trust, London, UK; †Department of Infectious Diseases and Immunity, Imperial College, London, UK; and ‡Department of Medical Microbiology, Marie-Curie Medical Institute, Tehran, Iran.

Corynebacterium propinquum is usually considered part of the normal human oropharyngeal flora and is rarely responsible for clinical infection. We report here what seems to be the first case of acute purulent urethral discharge in a young Iranian man with urethritis acquired after orogenital contact. Attention should be devoted to less common nondiphtheriae Corynebacterium species for differential diagnosis. Read More

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October 2013
4 Reads

Bacterial vaginosis-associated bacteria in men: association of Leptotrichia/Sneathia spp. with nongonococcal urethritis.

Sex Transm Dis 2013 Dec;40(12):944-9

From the *Department of Epidemiology, University of Washington, Seattle WA; †The Fred Hutchinson Cancer Research Center, Seattle, WA; ‡Children's National Medical Center, Washington, DC; and §Department of Medicine, University of Washington, Seattle, WA.

Background: Approximately 45% of nongonococcal urethritis cases have no identified etiology. Novel bacteria recently associated with bacterial vaginosis (BV) in women may be involved. We evaluated the association of idiopathic nongonococcal urethritis and 5 newly described BV-associated bacteria (BVAB). Read More

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December 2013
2 Reads

Characteristics of Sexually Transmitted Infections among High-Risk HIV-Positive Patients Attending an Urban Clinic in Uganda.

J Int Assoc Provid AIDS Care 2016 Jan-Feb;15(1):36-41. Epub 2013 Oct 21.

Research Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: Sexually transmitted infections (STIs) significantly increase HIV transmission. Sexually transmitted infections may be asymptomatic and therefore remain undiagnosed in HIV-positive persons. Routine screening and treatment of STIs in HIV-positive high-risk populations in sub-Saharan Africa have not been described previously. Read More

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April 2016
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Toward enhancing sexually transmitted infection clinic efficiency in an era of molecular diagnostics: the role of physical examination and risk stratification in men.

Sex Transm Dis 2013 Nov;40(11):886-93

From the Johns Hopkins University School of Medicine, Baltimore, MD.

Background: In an era of constrained resources, new molecular techniques may make it possible to detect common sexually transmitted infections (STIs) without physical examination in selected groups of men. Our objectives were to define the contribution of the physical examination in detecting clinically meaningful diagnoses that may not be identified by current laboratory methods and to identify characteristics that can stratify men into the appropriate risk category.

Methods: A retrospective study from a database of all male visits to 2 urban STI clinics in Baltimore between 1990 and 2001 was conducted. Read More

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November 2013

Reactive arthritis associated with Mycoplasma genitalium urethritis.

Diagn Microbiol Infect Dis 2013 Nov 10;77(3):278-9. Epub 2013 Sep 10.

Centre Hospitalier Universitaire de Bordeaux, Laboratoire de Bactériologie, 33076 Bordeaux, France.

Mycoplasma genitalium is an important cause of sexually transmitted infections that is gaining recognition and is an independent cause of acute and chronic nongonococcal urethritis in men. M. genitalium has been implicated as a possible causative factor in reactive arthritis. Read More

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November 2013
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