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Int J Radiat Biol 2022 Jun 27:1-21. Epub 2022 Jun 27.

Oak Ridge National Laboratory, Oak Ridge, TN, USA.

Background: There are few occupational studies of women exposed to ionizing radiation. During World War II, the Tennessee Eastman Corporation (TEC) operated an electromagnetic field separation facility of 1152 calutrons to obtain enriched uranium (U) used for the Hiroshima atomic bomb. Thousands of women were involved in these operations. Read More

Hum Cell 2022 Jul 8;35(4):1234-1247. Epub 2022 Jun 8.

Department of Thoracic Surgery, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Diffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL) globally, featuring heterogeneous clinical phenotypes and altered molecular manifestations. The long non-coding ribose nucleic acids (lncRNAs) play crucial roles in the diagnosis, treatment, and prognosis of DLBCL, requiring the exploration of complex functions and mechanisms. In this study, the expression of lncRNA TRIM52-AS1 in DLBCL tissues from the Cancer Genome Atlas (TCGA) database was initially analyzed and correlated to the data from collected clinical samples. Read More

Front Cell Infect Microbiol 2022 17;12:850509. Epub 2022 May 17.

Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL, United States.

Cutaneous T cell lymphoma (CTCL), a non-Hodgkin lymphoma, is thought to arise from mature tissue-resident memory T cells. The most common subtypes include Mycosis Fungoides and Sezary Syndrome. The role of skin microbiota remains unclear in the symptom manifestation of MF. Read More

Leuk Res Rep 2022 27;17:100318. Epub 2022 Apr 27.

Department of Hematology, General Hospital of Athens 'G Gennimatas', Athens, Greece.

We report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium wall. Read More

BMC Pulm Med 2022 Apr 28;22(1):165. Epub 2022 Apr 28.

Manchester Cancer Research Centre, Wilmslow Road, Manchester, M20 4QL, UK.

Background: Many Hodgkin lymphoma (HL) survivors are at increased risk of subsequent malignant neoplasms (SMN), including lung cancer, due to previous treatment for HL. Lung cancer screening (LCS) detects early-stage lung cancers in ever smokers but HL survivors without a heavy smoking history are ineligible for screening. There is a rationale to develop a targeted LCS. Read More

PLoS One 2022 28;17(4):e0267572. Epub 2022 Apr 28.

Department of Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background And Aims: Immune checkpoint inhibitors (ICIs) are used to treat several cancers, but they sometimes induce immune-related adverse events (irAEs). Patients with irAEs often have improved antitumor responses, but discontinuation of ICIs after irAEs is considered necessary. Resuming the use of ICIs after irAEs is preferable, but few studies have investigated the safety of ICI resumption after irAEs. Read More

Diagnostics (Basel) 2022 Apr 2;12(4). Epub 2022 Apr 2.

Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

This study aimed to build machine learning prediction models for predicting pathological subtypes of prevascular mediastinal tumors (PMTs). The candidate predictors were clinical variables and dynamic contrast-enhanced MRI (DCE-MRI)-derived perfusion parameters. The clinical data and preoperative DCE-MRI images of 62 PMT patients, including 17 patients with lymphoma, 31 with thymoma, and 14 with thymic carcinoma, were retrospectively analyzed. Read More

Cell Death Dis 2022 Apr 18;13(4):359. Epub 2022 Apr 18.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Nonalcoholic fatty liver disease (NAFLD) is an ubiquitous disease that exists across a wide spectrum ranging from steatosis, steatohepatitis, advanced fibrosis, and liver cirrhosis. Hallmarks of NAFLD are lipid accumulation, insulin resistance, and chronic low-grade inflammation. However, there currently are no medications approved for NAFLD. Read More

J Pediatr Hematol Oncol 2022 05 16;44(4):186-190. Epub 2022 Mar 16.

Department of Pediatrics, Kalawati Saran Children's Hospital.

The median age of presentation for Hodgkin lymphoma (HL) is lower in developing countries with a higher proportion under 5 years of age possibly attributable to the high prevalence of Epstein-Barr virus-driven disease. It is unclear whether the clinical presentation and outcomes of this cohort are different with concern regarding late effects being most pronounced in this age group. We report the outcome of children under 5 years of age enrolled in the InPOG-HL-15-01, the first multicentric collaborative study for newly diagnosed children and adolescents with HL from India. Read More

Int J Cancer 2022 06 3;150(11):1779-1791. Epub 2022 Feb 3.

Department of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Cancer is a significant cause of morbidity and mortality after solid organ transplantation (SOT) and related to lifelong immunosuppression. This retrospective registry study assessed for the first time in Finland population-based cancer risk and cancer mortality after all SOTs (lung and childhood transplantations included) as standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs). Data from transplant registries were linked with the data of Finnish Cancer Registry and Statistics Finland. Read More

Cureus 2022 Jan 4;14(1):e20924. Epub 2022 Jan 4.

Internal Medicine, Thoracic Diseases General Hospital Sotiria, Athens, GRC.

Superior vena cava syndrome (SVCS) is a clinical entity characterized by signs and symptoms arising from the obstruction or occlusion of the thin-walled superior vena cava (SVC) and can result in significant morbidity and mortality. Despite the rise of benign cases of SVCS, as a thrombotic complication of intravascular devices, it is most commonly seen secondary to malignancy as a consequence of thrombosis, direct invasion of tumor cells inside the vessel, or external compression. SVCS can be the initial presentation of a previously undiagnosed tumor in up to 60% of cases. Read More

BMC Pulm Med 2022 Jan 8;22(1). Epub 2022 Jan 8.

UOC Pneumologia Interventistica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Background: The management of non-small cell lung cancer (NSCLC) has become increasingly complex due to the evolution of personalized medicine approaches. Such approaches are characterized by the necessity of adequate tumor samples; hence, improved biopsy techniques are needed. Transbronchial lung cryobiopsy is a novel endoscopic procedure designed to collect peripheral pulmonary tissue, and it is currently employed in interstitial lung diseases. Read More

J Clin Oncol 2022 04 6;40(10):1091-1101. Epub 2022 Jan 6.

Department of Hematology, University Hospital F. Mitterrand and Inserm UMR 1231, Dijon, France.

Purpose: The AHL2011 study (ClinicalTrials.gov identifier: NCT01358747) demonstrated that a positron emission tomography (PET)-driven de-escalation strategy after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) provides similar progression-free survival (PFS) and overall survival (OS) and reduces early toxicity compared with a nonmonitored standard treatment. Here, we report, with a prolonged follow-up, the final study results. Read More

J Korean Med Sci 2022 Jan 3;37(1):e2. Epub 2022 Jan 3.

Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.

Background: In diffuse large B-cell lymphoma (DLBCL), bone marrow involvement (BMI) has an important clinical implication as a component of staging and International Prognostic Index. This study aimed to determine whether molecular analysis of immunoglobulin heavy chain (IgH) genes and positron emission tomography-computed tomography (PET/CT) could overcome the limitation of defining morphologic BMI by trephination biopsy and could increase the diagnostic accuracy or prognostic prediction.

Methods: A total of 94 de novo patients with DLBCL underwent PET/CT, polymerase chain reaction (PCR) test for detection of IgH gene rearrangement, and unilateral bone marrow (BM) trephination at diagnosis. Read More

BMJ Case Rep 2021 Dec 31;14(12). Epub 2021 Dec 31.

Gastroenterology Department, Centro Hospitalar e Universitário Coimbra, Coimbra, Portugal.

An 18-year-old woman presented with progressive oesophageal dysphagia, weight loss and night sweats over a 6-month period. Oesophagogastroduodenoscopy revealed a diffuse luminal narrowing with normal mucosa, whose biopsies were inconclusive. A cervical and thoracic CT scan showed a thickening of the upper oesophagus, densification of the mediastinal fat, several adenopathies and a 4. Read More

BMJ Case Rep 2021 Dec 30;14(12). Epub 2021 Dec 30.

Department of Clinical Hematology and Medical Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Burkitt lymphoma (BL) develops at an increased frequency in patients with HIV irrespective of the CD4 count. Lymph nodes and gastrointestinal tract are common sites of involvement by BL; however, primary chest wall BL is rare. A 52-year-old man on highly active antiretroviral therapy (HAART) for HIV with a CD4 count of 0. Read More

Rinsho Ketsueki 2021 ;62(11):1631-1634

Department of Hematology, Oita Prefectural Hospital.

Two cases of human herpesvirus 8 (HHV8)-negative effusion-based lymphoma (EBL) involving unilateral pleural effusion that regressed only after drainage are reported. Cases 1 and 2 were 91- and 81-year-old men with right and left pleural effusion, respectively. No chemotherapy was administered to either patient because of their advanced age and the presence of cardiac comorbidities. Read More

Rinsho Ketsueki 2021 ;62(11):1623-1627

Department of Hematology and Oncology, the University of Tokyo.

Chylothorax is an intrathoracic leakage of chyle due to thoracic duct damage. Malignant lymphoma is the most common nontraumatic cause of chylothorax. In March 2019, a 74-year-old woman presented to our department with bilateral pleural effusion and mesenteric/retroperitoneal masses. Read More

Blood Adv 2022 02;6(3):891-901

Department of Thoracic and Cardiovascular Surgery.

Epstein-Barr virus-positive (EBV-positive) B-cell lymphomas are common in immunocompromised patients and remain an unmet medical need. Here we report that MDM2 inhibitors (MDM2is) navtemadlin and idasanutlin have potent in vivo activity in EBV-positive B-cell lymphoma established in immunocompromised mice. Tumor regression was observed in all 5 EBV-positive xenograft-associated B-cell lymphomas treated with navtemadlin or idasanutlin. Read More

J Clin Exp Hematop 2022 Mar 26;62(1):35-40. Epub 2021 Nov 26.

Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan.

Marginal zone lymphoma (MZL) arising from the anterior mediastinum is rare. In the majority of reported cases, the tumor was incidentally discovered, reflecting its indolent clinical features. We present a 38-year-old woman who had no medical history, and presented with a bulky anterior mediastinal tumor complicated by life-threatening compression of the vasculature and bronchi. Read More

Asian J Surg 2022 Jan 23;45(1):506-507. Epub 2021 Nov 23.

Department of Thoracic Surgery, West China Hospital, Sichuan University, PR China; Chest Oncology Institute, West China Hospital, Sichuan University, PR China; Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, PR China. Electronic address:

Rinsho Shinkeigaku 2021 Dec 18;61(12):856-861. Epub 2021 Nov 18.

Department of Neurology, Ichinomiya-Nishi Hospital.

An 82-year-old man presented with subacute bilateral lower limb paralysis, deep sensory disturbance, and vesico-rectal disturbance. MRI of the spinal cord revealed a large gray matter-dominant lesion extending from the medulla oblongata to the lower thoracic spinal cord. The patient was treated with steroid-pulse therapy for myelitis, but without symptomatic improvement. Read More

BMJ Case Rep 2021 Nov 11;14(11). Epub 2021 Nov 11.

Department of Respiratory Medicine, Konan Medical Center, Kobe, Hyogo, Japan.

Int J Radiat Oncol Biol Phys 2022 03 9;112(4):913-925. Epub 2021 Nov 9.

Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Oxford Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Purpose: In some patients with Hodgkin lymphoma (HL), proton beam therapy (PBT) may reduce the risk of radiation-related cardiovascular disease (CVD) and second cancers (SC) compared with photon radiation therapy (RT). Our aim was to identify patients who benefit the most from PBT in terms of predicted 30-year absolute mortality risks (AMR) from CVD and SC, taking into account individual background, chemotherapy, radiation, and smoking-related risks.

Methods And Materials: Eighty patients with supradiaphragmatic HL treated with PBT between 2015 and 2019 were replanned using optimal photon RT. Read More

Radiology 2022 02 9;302(2):438-445. Epub 2021 Nov 9.

From the Department of Radiology (D.A.S., E.K., S.H.T., N.H.R.) and Department of Medicine, Division of Hematology and Oncology (P.C.), University Hospitals Cleveland Medical Center/Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106; and Blood and Marrow Transplant Program, The Ohio State University, Columbus, Ohio (M.d.L.).

Background Chimeric antigen receptor (CAR) T-cell immunotherapy is increasingly used for refractory lymphoma but may lead to cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Imaging may assist in clinical management. Associations between CRS or ICANS grade and imaging findings remain not fully established. Read More

Front Cell Dev Biol 2021 3;9:661272. Epub 2021 Aug 3.

Sorbonne University, INSERM, Research Unit on Cardiovascular and Metabolic Disease UMR ICAN, Department of Endocrine Biochemistry and Oncology, AP-HP, Hôpital Pitié Salpêtrière, Paris, France.

Cell-free DNA (cfDNA) analysis is a minimally invasive method that can be used to detect genomic abnormalities by directly testing a blood sample. This method is particularly useful for immunosuppressed patients, who are at high risk of complications from tissue biopsy. The cfDNA tumor fraction (TF) varies greatly across cancer type and between patients. Read More

JACC CardioOncol 2021 Sep 21;3(3):343-359. Epub 2021 Sep 21.

Cardio-Oncology Center of Excellence, Washington University, St. Louis, Missouri, USA.

Radiation therapy is an important component of cancer therapy for many malignancies. With improvements in cardiac-sparing techniques, radiation-induced cardiac dysfunction has decreased but remains a continued concern. In this review, we provide an overview of the evolution of radiotherapy techniques in thoracic cancers and associated reductions in cardiac risk. Read More

Clin Nucl Med 2022 Mar;47(3):e262-e264

Abstract: An 82-year-old man with a background of non-Hodgkin lymphoma in remission, resected left lower lobe adenocarcinoma (stage IA), and resected cutaneous melanoma of the left forearm more than 5 years prior presented with cerebral metastatic disease. Excision biopsy confirmed adenocarcinoma of lung origin. Further evaluation with 18F-FDG PET/CT demonstrated FDG-avid disease in the right thorax, axilla, and lower neck and isolated cutaneous uptake in the right forearm. Read More

Rev Esp Enferm Dig 2022 05;114(5):289-290

Gastroenterology, Hospital de São João, Portugal.

An 83-year-old female with history of silicosis was referred for upper endoscopy due to duodenal wall thickness detected in thoracic computer tomography (CT). Upper endoscopy revealed multiple small (1 to 5 mm), whitish polypoid lesions, involving a discrete portion of the descending part of the duodenum with 3 cm extension. Read More

Clin J Gastroenterol 2021 Dec 28;14(6):1632-1636. Epub 2021 Aug 28.

Department of Gastroenterology, General Hospital of Nikea-Piraeus 'Agios Panteleimon', Athens, Greece.

Hyperplastic polyps consist a very frequent finding in colonoscopy having a very low potential to malignancy. According to the international guidelines, it is recommended that all polyps should be resected except for diminutive (≤ 5 mm) rectal and rectosigmoid polyps which are predicted with confidence to be hyperplastic. Therefore, in departments where optical diagnosis can be ensured, a "resect and discard" strategy may be implemented for diminutive polyps. Read More