Search Our Scientific Publications & Authors

BMC Pulm Med 2019 Feb 21;19(1):48. Epub 2019 Feb 21.

Department of Hematology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan.

Background: Pulmonary non-Hodgkin lymphoma (NHL) is rare. The most frequent subtype of pulmonary NHL is low-grade B-cell lymphoma, such as lymphoma of mucosa-associated lymphoma tissue. Extranodal natural killer cell/T-cell lymphoma, nasal type (ENKL) is characterized by predominant extranodal involvement and association with Epstein-Barr virus (EBV). Read More

Lancet Oncol 2019 Feb 15;20(2):202-215. Epub 2019 Jan 15.

LYSA Imaging, Hôpital H Mondor, Creteil, France.

Background: Increased-dose bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) improves progression-free survival in patients with advanced Hodgkin lymphoma compared with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), but is associated with increased risks of haematological toxicity, secondary myelodysplasia or leukaemia, and infertility. We investigated whether PET monitoring during treatment could allow dose de-escalation by switching regimen (BEACOPP to ABVD) in early responders without loss of disease control compared with standard treatment without PET monitoring.

Methods: AHL2011 is a randomised, non-inferiority, phase 3 study done in 90 centres across Belgium and France. Read More

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

Eur Radiol 2019 May 13;29(5):2553-2559. Epub 2018 Dec 13.

Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany.

Objectives: Increasing awareness of potential side effects from gadolinium-based contrast agents has underlined the need for contrast-free magnetic resonance imaging (MRI). Numerous recent articles evaluated the risk of potential brain deposits, with the result that research is putting the focus more on alternative unenhanced imaging techniques. The aim of this study was to determine the need for contrast media for chest MRI in primary staging and follow-up care of lymphoma. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13291

Department of Pathology, Weihai Municipal Hospital, Weihai, Shandong, China.

Rationale: Primary diffuse large B-cell lymphoma of the chest wall is extremely rare. A majority of the pleural lymphomas develop in patients with chronic tuberculous pyothorax. The underlying mechanism might be attributed to the sustained stimulation of chronic inflammation. Read More

Proc Natl Acad Sci U S A 2018 12 19;115(50):12805-12810. Epub 2018 Nov 19.

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

Noncoding RNAs have substantial effects in host-virus interactions. Circular RNAs (circRNAs) are novel single-stranded noncoding RNAs which can decoy other RNAs or RNA-binding proteins to inhibit their functions. The role of circRNAs is largely unknown in the context of Kaposi's sarcoma herpesvirus (KSHV). Read More

Kyobu Geka 2018 11;71(12):1013-1017

Department of General Thoracic Surgery, Fukuoka Higashi Medical Center, Koga, Japan.

Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is associated with pre-existing infections or autoimmune disorders. We report a case of lung cancer initially suspected of MALT lymphoma. The patient was a 73-year-old woman. Read More

Biomedica 2018 09 1;38(3):298-302. Epub 2018 Sep 1.

Departamento de Hemato-Patología, Fundación Valle del Lili, Cali, Colombia.

The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis. Read More

Clin Physiol Funct Imaging 2019 Jan 3;39(1):78-84. Epub 2018 Oct 3.

Department of Clinical Physiology and Nuclear Medicine, Lund University and Skåne University Hospital, Malmö, Sweden.

Background: 18F-FDG-PET/CT has become a standard for assessing treatment response in patients with lymphoma. A subjective interpretation of the scan based on the Deauville 5-point scale has been widely adopted. However, inter-observer variability due to the subjectivity of the interpretation is a limitation. Read More

Transpl Infect Dis 2019 Feb 30;21(1):e13005. Epub 2018 Oct 30.

Division of Pulmonary, Critical Care, and Sleep Medicine, Westchester Medical Center, Valhalla, New York.

Primary effusion lymphoma (PEL) is a rare mature B-cell non-Hodgkin's lymphoma arising in body cavities and presenting with effusions. It has been described predominantly in patients with impaired immunity from the acquired immunodeficiency syndrome and is associated with the Human Herpesvirus-8 (HHV-8). Seldom has PEL been diagnosed in persons negative for the human immunodeficiency virus (HIV), and in such cases it has occurred primarily in the setting of posttransplant immunosuppression. Read More

Vet Clin Pathol 2018 Dec 19;47(4):643-648. Epub 2018 Sep 19.

Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon.

A 9-year-old spayed female Curly Coated Retriever was referred for evaluation of generalized peripheral lymphadenomegaly. The dog was clinically healthy on presentation with no anomalies detected on complete blood count, serum biochemistry, urinalysis, or three-view thoracic radiographs. Fine-needle aspiration (FNA) and cytology of the peripheral lymph nodes were consistent with lymphoma with an intermediate-sized lymphoid population. Read More

Clin Nucl Med 2018 Nov;43(11):857-859

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China.

Primary bone lymphoma without classic nodal lesions or advanced disease may be mistaken for other osseous diseases, especially when involving a single bone site. In this patient, a series of imaging modalities including MRI, bone scan, and F-FDG PET/CT revealed only 1 solitary osseous lytic lesion with abnormal uptake in the third thoracic vertebra, suggesting a primary skeletal malignancy. The subsequent histopathologic examination confirmed the diagnosis of diffuse large B-cell lymphoma. Read More

Pan Afr Med J 2018 24;30:57. Epub 2018 May 24.

Service de Chirurgie Plastique, CHU Mohammed VI, Marrakech, Maroc.

Malignant lymphomas are a group of cancers that arise in the lymphoid tissue, in the lymph nodes or in extranodal sites due to neoplastic lymphocytic cell transformation. Within this group, malignant non-Hodgkin lymphomas are distinctive. We report a case of diffuse advanced and extremely aggressive malignant cutaneous non-Hodgkin lymphoma. Read More

Hematol Oncol 2019 Feb 5;37(1):3-14. Epub 2018 Sep 5.

Institute of Hematology Lorenzo e Ariosto Seràgnoli, University of Bologna, Bologna, Italy.

The introduction of new therapeutic agents in chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL), including the new kinase inhibitor idelalisib, has changed the therapeutic landscape of these diseases. However, the use of idelalisib is associated with a peculiar profile of side effects, which require an optimization of the current approach to prophylaxis and supportive treatment. Moving from the recognition that the abovementioned issue represents an unmet need in CLL and FL, a multidisciplinary panel of experts was convened to produce a consensus document aiming to provide practical recommendations for the management of the side effects during idelalisib therapy for CLL and FL. Read More

Mol Clin Oncol 2018 Sep 16;9(3):264-268. Epub 2018 Jul 16.

Department of Infectious Diseases, Capital Medical University Affiliated Beijing You An Hospital, Beijing 100069, P.R. China.

Primary diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma; however, the involvement of the lung and central nervous system (CNS) in patients with DLBCL is rare. Furthermore, patients with DLBCL rarely exhibit specific clinical symptoms, which may delay definitive diagnosis. The present study reports the case of a 42-year-old man suffering from primary DLBCL with concurrent pulmonary and cerebral involvement. Read More

Pediatr Neurosurg 2018 15;53(5):311-316. Epub 2018 Aug 15.

Department of Neurosurgery, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania, USA.

Primary central nervous system lymphoma (PCNSL) is rare in children with immunocompromise as an important risk factor. A 7-year-old girl with unspecified T-cell immunodeficiency presented with left-sided weakness and was found to have a right-sided frontal lobe mass on imaging. The mass was resected; histopathology and molecular studies evidenced diffuse large B-cell lymphoma. Read More

Case Rep Womens Health 2018 Jul 26;19:e00065. Epub 2018 May 26.

Institute of Laboratory Medicine, University Hospital, LMU, Munich, Germany.

We report the initial diagnosis in a 28-year-old nulliparous woman of a primary mediastinal B-cell lymphoma in late pregnancy. For several weeks the patient had had symptoms of mediastinal obstruction, such as dyspnea, cough, swelling of the face and upper limbs. However, these symptoms had been misattributed to the pregnancy and a common cold. Read More

J Clin Exp Hematop 2018 Sep 8;58(3):141-147. Epub 2018 Aug 8.

An 80-year-old man presented with the accumulation of pleural fluid in the right thoracic cavity. Serum electrophoresis revealed an M-component and immunofixation confirmed IgM/λ. The level of IgM was 1,526 mg/dL. Read More

J Emerg Med 2018 09 23;55(3):399-401. Epub 2018 Jul 23.

Department of Emergency Medicine, University of California, San Diego, California.

Background: Pancoast syndrome is an uncommon complication of apical lung tumors. Symptoms include pain, brachial plexopathy, and Horner's syndrome, and are the result of extrinsic compression of tissues within the thoracic inlet. Lymphoma is a very rare etiology. Read More

Rev Neurol 2018 08;67(4):155-156

Complejo Asistencial de Segovia, Segovia, Espana.

Emerg Med Clin North Am 2018 Aug 12;36(3):577-584. Epub 2018 Jun 12.

Emergency Medicine Residency, Norman Regional Health Systems, GME Office, 901 North Porter, Norman, OK 73071, USA.

Superior vena cava syndrome occurs from obstruction of the superior vena cava. The most common cause is malignancy. Small cell lung cancer and non-Hodgkin lymphoma are the most frequent culprits. Read More

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):383-388

Department of Pathology, Military Hospital, Jalandhar, Punjab, India.

Tuberculosis (TB) and Non-Hodgkins lymphoma (NHL) share similar clinical and radiological features, which make diagnosis a challenge. It is often difficult to rule out a diagnosis of extrapulmonary and/or disseminated TB because of its paucibacillary nature and difficulty in accessing the involved organs. In countries with high prevalence of TB like ours, empirical antitubercular treatment (ATT) is started, and the patient is followed up closely for response. Read More

Thorac Cardiovasc Surg Rep 2018 Jan 28;7(1):e18-e20. Epub 2018 Jun 28.

Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

 Pacemaker infections rates are high compared with the incidence of primary malignant cardiac tumors. However, they can look alike in diagnostics and patient presentation.  We hereby report a rare case of a suspected pacemaker endocarditis which in fact turned out to be a primary cardiac B cell lymphoma. Read More

Clin Nucl Med 2018 Aug;43(8):e259-e264

From the Departments of Hematology-Oncology.

Purpose: Primary central nervous system lymphoma (PCNSL) has a poor prognosis. There has been limited study evaluating the role of interim PET/CT in PCNSL. This prospective study investigated the interim response using sequential brain PET/CT with C-methionine (C-MET) to provide prognostic information during the treatment of PCNSL. Read More

Rofo 2018 07 6;190(7):638-640. Epub 2018 Jun 6.

Institute for Diagnostic and Interventional Radiology, University Hospital Cologne, Germany.

Ulster Med J 2018 May 30;87(2):134-135. Epub 2018 May 30.

Consultant, Department of Haematology Belfast City Hospital.

BMC Cardiovasc Disord 2018 05 31;18(1):107. Epub 2018 May 31.

Department of System Biology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: The main etiology of constrictive pericarditis (CP) has changed from tuberculosis to therapeutic mediastinal radiation and cardiac surgery. Occult constrictive pericardial disease (OCPD) is a covert disease in which CP is manifested in a condition of volume overload.

Case Presentation: A 60-year-old patient with a history of thoracic radiation therapy for non-Hodgkin's lymphoma (40 years earlier) was transferred to our hospital for treatment of repeated congestive heart failure. Read More

Respir Investig 2018 May 12;56(3):258-262. Epub 2018 Feb 12.

Department of Respirology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan. Electronic address:

Cases of extracorporeal membrane oxygenation (ECMO) bridged lung transplantation (LTx) are rare in Japan because an allocation system to prioritize patients based on urgency remains to be established. For critically ill patients who cannot wait for a brain-dead donor LTx, ECMO bridge to living-donor LTx may be the only practical option. A 21-year-old woman with pleuroparenchymal fibroelastosis after hematopoietic stem cell transplantation was admitted to our hospital with rapidly progressive respiratory failure. Read More

Mol Clin Oncol 2018 Jun 2;8(6):729-732. Epub 2018 Apr 2.

The Central Laboratory, The First Hospital of Jiaxing, Jiaxing, Zhejiang 314001, P.R. China.

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). DLBCL presents with pleural involvement at an advanced stage; however, primary pleural lymphomas without any other site of involvement are rare, and the possibility of misdiagnosis is high, particularly in developing countries, where tuberculosis or other severe pulmonary infections remain a major health concern. Furthermore, lymphoma and tuberculosis share a number of common clinical characteristics, such as fever, night sweats, feeling of satiety after a small meal, fatigue and unexplained weight loss, among others. Read More

Vet Radiol Ultrasound 2018 Sep 3;59(5):507-515. Epub 2018 May 3.

The Departments of Clinical Sciences and Population Medicine & Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853.

Acute myeloid leukemia is an uncommon hematopoietic neoplasm of dogs that should be differentiated from lymphoid neoplasms, such as lymphoma, because of different treatment protocols and a worse prognosis. Thoracic radiography is performed frequently in dogs with suspected hematopoietic neoplasia, and detecting a mediastinal mass often prioritizes lymphoma as the most likely diagnosis. However, we have observed a mediastinal mass in several dogs with acute myeloid leukemia and hypothesized that (1) the frequency of a mediastinal mass was higher and (2) the size of the mass was larger in dogs with acute myeloid leukemia compared to dogs with lymphoid neoplasms. Read More

World Neurosurg 2018 Oct 26;118:86-87. Epub 2018 Apr 26.

Department of Neurosurgery, Van Yuzuncu Yıl University, Dursun Odabası Faculty of Medicine, Van, Turkey.

A 55-year-old male who complained of frequent back pain accompanied by increasing weakness in the lower extremities was admitted to our hospital's Neurosurgery Department. No additional disease was in his history. Magnetic resonance imaging of the thoracic area, anterior epidural space, and paravertebral area revealed an approximately 55 × 9 mm lymphoma pressuring the spinal cord from the anterior. Read More

World Neurosurg 2018 Jul 17;115:157-158. Epub 2018 Apr 17.

Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

A 71-year-old man presented with neck and upper back pain to the emergency department. Magnetic resonance imaging of the thoracic demonstrated a T2 vertebral lesion with epidural spinal cord compression. Considering the degree of severe spinal cord compression and the absence of a pathologic diagnosis, an urgent separation surgery was planned. Read More

Nucl Med Commun 2018 Jun;39(6):572-578

Departments of Radiology, Nuclear Medicine and Molecular Imaging, Medical Imaging Center.

Purpose: This study aims to investigate whether clinical, laboratory, and fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT findings can discriminate between mediastinal Hodgkin's lymphoma and primary mediastinal B-cell lymphoma (PMBCL).

Patients And Methods: This retrospective study included 56 patients (42 with mediastinal Hodgkin's lymphoma and 14 with PBMCL). Differences in clinical, laboratory, and F-FDG PET/CT metrics were assessed between Hodgkin's lymphoma and PMBCL. Read More

Cureus 2018 Feb 6;10(2):e2162. Epub 2018 Feb 6.

Department of Hematology and Oncology, Staten Island University Hospital.

Primary bronchus-associated lymphoid tissue (BALT) lymphoma comprises 5% of non-Hodgkin's lymphoma (NHL) and usually has an indolent course. Synchronous primary lung cancers with BALT lymphoma are seldom seen in patients with adenocarcinoma of the lung. Synchronous squamous cell carcinoma (SCC) and BALT lymphoma is an extremely rare occurrence. Read More

Cancer Immunol Immunother 2018 06 19;67(6):935-947. Epub 2018 Mar 19.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Partner site Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.

The first therapeutic proteasome inhibitor bortezomib has clinical efficacy in mantle cell lymphoma (MCL) which resulted in its incorporation in treatment algorithms for this disease. Impairment of proteasomal function by bortezomib is mediated via inhibition of the 20S core particle. However, proteasome function can also be modified by targeting upstream components of the ubiquitin-proteasome system. Read More

BMC Cancer 2018 03 12;18(1):281. Epub 2018 Mar 12.

The First Affiliated Hospital of Wenzhou Medical University & Key Laboratory of Heart and Lung, Zhejiang, 325035, China.

Background: The primary pulmonary lymphoma (PPL), with a low incidence, was highly misdiagnosed in clinic. The present study analyzes the clinical features, laboratory and imaging data, pathologic characteristics, and summarizes misdiagnosis reasons of PPL cases, aims to provide a better understanding and increase the accuracy of early diagnosis and minimize the misdiagnosis of PPL.

Methods: The clinical data of 19 cases were collected from the first affiliated hospital of Wenzhou medical university (PRC) from April 2010 to May 2016. Read More

Vasc Endovascular Surg 2018 Jul 11;52(5):367-370. Epub 2018 Mar 11.

5 Faculty of Medicine, Department of Medicine, Charles University and University Hospital, Hradec Kralove, Czech Republic.

An aggressive periaortic lymphoma could very rarely invade the aortic wall. We present a unique case of a patient with symptomatic thoracic aneurysm and imminent rupture due to the periaortic lymphoma, in which endovascular treatment using stent graft was applied. After stabilization of the aorta and histological confirmation of aggressive B-cell lymphoma by computed tomography-guided biopsy, the antilymphoma therapy was initiated. Read More

Niger J Clin Pract 2018 Mar;21(3):392-394

Department of Thoracic Surgery, School of Medicine, Second Affliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, China.

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymph tissue (MALT lymphoma) is a rare subtype of marginal zone B-cell lymphoma. Most primary MALT lymphoma occurs in the stomach, while lung is an uncommon site of MALT lymphoma. We herein report a case of MALT lymphoma in a 44-year-old female who underwent a pulmonary lobectomy and received rituximab plus CHOP chemotherapy regimen. Read More

Medicine (Baltimore) 2018 Mar;97(10):e0080

Department of Gastroenterology.

Rationale: Primary central nervous system lymphoma (PCNSL) with initial manifestations of constipation and intestinal obstruction (IO) is rare.

Patient Concerns: A 50-year-old Chinese male patient was admitted to the gastroenterology department due to constipation and abdominal distention for 8 days. He had experienced intermittent back pain for 3 years prior to admission. Read More

Aust Vet J 2018 Mar;96(3):83-85

Willows Veterinary Centre and Referral Service, Highlands Road, Solihull B90 4NH, UK.

Case Report: A 6-year-old neutered male British Shorthair cat presented with two rapidly growing subcutaneous masses, one over each thoracic wall. High-grade, non-Hodgkin's lymphoma was confirmed following histopathology, immunohistochemistry and PCR analysis for antigen receptor re-arrangements. Following biopsy there was rapid regression of the remaining neoplastic tissue with no medical treatment. Read More

Zhongguo Gu Shang 2017 Dec;30(12):1141-1146

Huzhou Central Hospital MRI Room, Huzhou 313000, Zhejiang, China;

Objective: To investigate CT and MRI characteristics of primary spinal large B cell lymphoma.

Methods: CT and MRI data of 23 patients with primary spinal large B cell lymphoma confirmed by histopathology were retrospectively analyzed from March 2011 to August 2015. Among them, including 14 males and 9 females aged from 28 to 70 years old with an average of 53. Read More

Medicine (Baltimore) 2018 Feb;97(7):e9992

Bone Marrow Transplantation Center.

Rationale: Cytokine release syndrome (CRS) is a common and potentially fatal complication of CAR-T cell therapy. However, compartment CRS is relatively rare in hematological malignancies, as well as in solid tumors. The pathogenesis and prognosis of compartment CRS are unclear and there is no standardized treatment yet. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Feb;26(1):159-165

Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China. E-mail:

Objective: To investigate the significance of H3K27me3 and its methyltransferase EZH2 in predicting the short-term and long-term outcome of newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL).

Methods: The paraffin wax speciments of 102 DLBCL patients in Fujian Medical University Cancer Hospital were collected. The expression of H3K27me3, EZH2 and BCL-2 protein were detected using tissue array made by tissue microarray(TMA) technique and immunohistochemistry method. Read More

Histopathology 2018 06 25;72(7):1228-1230. Epub 2018 Mar 25.

Department of Pathology, Ghent University Hospital, Ghent, Belgium.

BMJ Case Rep 2018 Jan 23;2018. Epub 2018 Jan 23.

Infectious diseases, NHS Grampian, Aberdeen, UK.

A 68-year-old man presented with a 4-day history of worsening knee and arm pain. On examination, there was erythema and swelling of the left knee and both wrists. Joint aspiration grew Blood tests showed an unusually high total protein level (100 g/L) and an IgM kappa paraprotein band of 45 g/L on protein electrophoresis. Read More

Ecancermedicalscience 2017 12;11:789. Epub 2017 Dec 12.

Universidad Cooperativa de Colombia, Facultad de Medicina, Departamento de Investigación -GRIVI, Villavicencio, Colombia.

This report is of a 68-year-old male patient with a three-year history of severe, progressive, low urinary tract symptoms (LUTS) with a score of 20 points on the International Symptom Scale. The patient received alpha-1-blocker therapy without adequate response. Transurethral resection of the prostate was performed, and the anatomopathological report indicated the presence of a haematolymphoid small-cell neoplasia and glandulostromal prostatic hyperplasia. Read More

Case Rep Oncol Med 2017 10;2017:5640186. Epub 2017 Nov 10.

Department of Pneumology, Lungenklinik Heckeshorn, HELIOS Klinikum Emil von Behring, Berlin, Germany.

We present a 74-year-old male with nonspecific interstitial pneumonia (NSIP) during treatment with ibrutinib for mantle cell lymphoma. Previously, the patient had received six cycles of bendamustine and rituximab and six cycles of R-CHOP, followed by rituximab maintenance therapy. Respiratory tract complications of ibrutinib other than infectious pneumonia have not been mentioned in larger trials, but individual case reports hinted to a possible association with the development of pneumonitis. Read More

Gen Thorac Cardiovasc Surg 2018 Jul 19;66(7):435-438. Epub 2017 Dec 19.

Division of Thoracic Surgery, Department of Surgery, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa, 259-1193, Japan.

We reported a surgical case of methotrexate-associated lymphomatoid granuloma. A 69-year-old female had been treated with methotrexate for rheumatoid arthritis for 35 months. The patient underwent partial resection of the right upper pulmonary lobe for lung cancer when she was 67 years old. Read More

Acta Dermatovenerol Croat 2017 Oct;25(3):248-250

Prof. Romana Čeović, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology School of Medicine, University of Zagreb, 10000 Zagreb, Šalata 4, Croatia;

Dear Editor, the association between lymphomas and autoimmune manifestations, as well as the prevalence of the cases of coexistent lymphomas and autoimmune conditions, has not been completely established (1-3). Since cutaneous T-cell lymphoma (CTCL) cases are rare, any hypothesis can only be based on case reports or small case series. We present the case of a male patient with folliculotropic mycosis fungoides (FMF) and synchronous autoimmune hepatitis (AIH) with extremely high levels of cancer antigen 19-9 (CA 19-9). Read More

Ann Thorac Surg 2018 Jan;105(1):e19-e20

Department of Cardiovascular Surgery, Kurashiki Central Hospital, Okayama, Japan.

We describe the case of a 69-year-old man with a thoracic pseudoaneurysm caused by a diffuse large B-cell lymphoma. He had a large mass inside the aortic arch. Five weeks later, an asymptomatic aneurysm protruding from the minor curvature of the distal aortic arch was observed. Read More