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    1 OF 112

    Role of FNA and Special Stains in Rapid Cytopathological Diagnosis of Pulmonary Nocardiosis.
    Acta Cytol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Chest and Pulmonary Medicine, Dayanand Medical College and Hospital, Ludhiana, India.
    Background: Nocardia, a gram-positive aerobic bacillus of the Actinomycetales family, is a significant opportunistic pathogen in immunocompromised individuals. Clinical and radiological features of pulmonary nocardiosis are nonspecific and can be misdiagnosed as tuberculosis, pneumocystis, staphylococcal or fungal infections, or as malignancy. Aspiration cytology with special stains is a quick and effective approach for accurate diagnosis. Read More

    Nocardia infections in the transplanted host.
    Transpl Infect Dis 2018 Apr 18:e12902. Epub 2018 Apr 18.
    Department of Medicine, Duke University Medical Center, Durham, NC, USA.
    Background: Nocardia are uncommon pathogens that disproportionately afflict the immunocompromised host. Epidemiology and outcome data of Nocardia infections in transplant recipients are limited.

    Methods: We performed a retrospective chart review of all patients at Duke University Hospital with a history of solid organ transplant (SOT) or hematopoietic cell transplant (HCT) and at least one positive culture for Nocardia between 1996-2013. Read More

    A 20-Year Experience with Nocardiosis in Solid Organ Transplant (SOT) Recipients in the Southwestern United States: A Single-Center Study.
    Transpl Infect Dis 2018 Apr 18:e12904. Epub 2018 Apr 18.
    Department of Medicine, Division of Infectious Diseases, The University of Arizona, Tucson, AZ, 85724.
    Background: Nocardiosis is a life-threatening opportunistic infection. Solid organ transplant (SOT) recipients are at higher risk (incidence 0.04% to 3. Read More

    spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid.
    Case Rep Infect Dis 2018 30;2018:1749691. Epub 2018 Jan 30.
    Wright State University Boonshoft School of Medicine, Weber CHE 2nd Floor, 128 Apple St., Dayton, OH 45419, USA.
    We describe a rare infection with spp. ( species identification based on high-performance liquid chromatography analysis) in a 68-year-old renal transplant recipient. He presented with pneumonia complicated by hypoxic respiratory failure. Read More

    Efficacy of recombinant protein vaccines for protection against Nocardia seriolae infection in the largemouth bass Micropterus salmoides.
    Fish Shellfish Immunol 2018 Apr 14. Epub 2018 Apr 14.
    Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, No. 1 Shuefu Road, Neipu, Pingtung 91201, Taiwan, ROC; Research Center for Animal Biologics, National Pingtung University of Science and Technology, No. 1 Shuefu Road, Neipu, Pingtung 91201, Taiwan, ROC. Electronic address:
    A reverse vaccinology-based survey of potent antigens associated with fish nocardiosis was conducted using the largemouth bass, Micropterus salmoides, with an aim to develop subunit vaccines. The antigens selected from the virulent strain Nocardia seriolae 961113 include the gene products of NGL2579 (GAPDH), NGL5701 (MMP), NGL4377 (OCTase), NGL4486 (ABC transporter), NGL3372 (LLE), NGL3388 (GHf10), NGL6627 (Antigen-85), NGL6696 (Esterase), and NGL6936 (CBP). These antigens were heterologously expressed in E. Read More

    Adjuvant effect in aquaculture fish of cell-wall glycolipids isolated from acid-fast bacteria.
    Dev Comp Immunol 2018 Apr 14. Epub 2018 Apr 14.
    The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24 Korimoto, Kagoshima, 890-8580, Japan; Faculty of Fisheries, Kagoshima University, 4-50-20 Shimoarata, Kagoshima, 890-0056, Japan. Electronic address:
    Mycobacteriosis and nocardiosis in cultured fish caused by infections with acid-fast bacteria, are responsible for large economic losses globally. In this study, we suggest a novel adjuvant using glycolipids that activates host immune systems. The immune response to glycolipids stimulation was investigated using ginbuna crucian carp. Read More

    Nocardia choroidal abscess-a Case report with Review of literature.
    Nepal J Ophthalmol 2017 Jul;9(18):187-189
    Introduction: Nocardia is a common cause of corneal infections but is a rare cause of choroidal abscess. We report a rare case of choroidal abscess, secondary to Nocardia and its management.

    Case: We report a case of choroidal abscess secondary to Nocardia asteroides species in an immunocompetent young male diagnosed by culture positivity of vitreous biopsy. Read More

    Pulmonary Reinfection by Nocardia in an Immunocompetent Patient with Bronchiectasis.
    Intern Med 2018 Mar 30. Epub 2018 Mar 30.
    Department of Respiratory Medicine, Aichi Cancer Center Aichi Hospital, Japan.
    Pulmonary reinfection by Nocardia has been rarely reported. We describe a case of pulmonary reinfection by Nocardia in an immunocompetent patient. An 82-year-old immunocompetent woman with bronchiectasis presented with exacerbation of cough. Read More

    Bacterial pneumonia in kidney transplant recipients.
    Respir Med 2018 Apr 6;137:89-94. Epub 2018 Mar 6.
    Division of Nephrology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium. Electronic address:
    Bacterial pathogens are the most frequent cause of pneumonia after transplantation. Early after transplantation, recipients are at higher risk for nosocomial infections. The most commonly encountered pathogens during this period are gram-negative bacilli (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa …), but gram-positive coccus such as Staphylococcus aureus or Streptococcus pneumoniae and anaerobic bacteria can also be found. Read More

    Primary Infection Causing a Fluorodeoxyglucose-Avid Right Renal Mass in a Redo Lung Transplant Recipient.
    Case Rep Transplant 2018 7;2018:9752860. Epub 2018 Feb 7.
    Department of Pulmonary Medicine, Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
    Immunosuppression after lung transplantation may increase susceptibility to opportunistic infection and is associated with early and delayed deaths in lung transplant recipients. Factors that may predispose lung transplant recipients to opportunistic bacterial and fungal infections include prolonged corticosteroid use, renal impairment, treatment of acute rejection, and post-transplant diabetes mellitus. We present a unique case of a 63-year-old woman with diabetes mellitus who underwent redo lung transplantation. Read More

    Clinical assessment of a spp. polymerase chain reaction (PCR)-based assay for the diagnosis of nocardiosis.
    J Clin Microbiol 2018 Mar 21. Epub 2018 Mar 21.
    Université Paris Descartes, Sorbonne Paris Cité, AP-HP, Hôpital Necker Enfants Malades, Centre d'Infectiologie Necker-Pasteur and Institut Imagine, France
    Diagnosis of nocardiosis, a severe opportunistic infection, is challenging. We assessed the specificity and sensitivity of a 16S PCR-based assay performed on clinical samples. In this multicenter study (January 2014 - April 2015), patients admitted to three hospitals who had an underlying condition favoring nocardiosis, clinical/radiological signs compatible with nocardiosis and a PCR performed on a clinical sample were included. Read More

    Increased Incidence of Nocardial Infections in an Era of Atovaquone Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplant Recipients.
    Biol Blood Marrow Transplant 2018 Mar 16. Epub 2018 Mar 16.
    David Geffen School of Medicine, University of California, Los Angeles, California; Division of Hematology-Oncology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California.
    Nocardial infections have been rare after allogeneic hematopoietic stem cell transplantation (HSCT). We report 10 recent cases of late-onset nocardiosis (median time of onset of 508 days after transplantation) primarily in patients on high doses of corticosteroids for graft-versus-host disease. All 10 patients had pulmonary infection caused by Nocardia species susceptible to trimethoprim-sulfamethoxazole (TMP-SMX). Read More

    Relationship between the duration of trimethoprim/sulfamethoxazole treatment and the clinical outcome of pulmonary nocardiosis.
    Respir Investig 2018 Mar 22;56(2):166-172. Epub 2018 Feb 22.
    Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Saga Prefecture 849-8501, Japan. Electronic address:
    Background: Despite treatment, pulmonary nocardiosis, which is a rare opportunistic disease caused by Nocardia species, has poor clinical outcomes including recurrence and death. Currently, the treatment regimen and duration for pulmonary nocardiosis are not fully understood. The present study aimed to clarify the factors related to the clinical outcome of pulmonary nocardiosis. Read More

    Pulmonary Nocardiosis: Unusual Presentation in Intensive Care Unit.
    Indian J Crit Care Med 2018 Feb;22(2):125-127
    Department of Critical Care Medicine, Regency Hospital, Kanpur, Uttar Pradesh, India.
    Pulmonary nocardiosis is a rare disease, which mainly affects immunocompromised hosts such as uncontrolled diabetics; HIV patients; and patients on immunosuppressive therapies such as anticancer drugs, systemic steroids, and transplant recipients. The diagnosis is often missed and delayed, resulting in inappropriate treatment and thus higher mortality. We are reporting a case of pulmonary nocardiosis with acute presentation in an immune-competent host, who presented with community-acquired pneumonia to the Intensive Care Unit. Read More

    Rare case of osteomyelitis of tibial shaft caused by Nocardia cyriacigeorgica.
    Folia Microbiol (Praha) 2018 Mar 5. Epub 2018 Mar 5.
    Department of Orthopaedics, First Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Úvalu 84, 150 06, Prague 5, Czech Republic.
    Nocardiosis is a rare infection caused by the aerobic actinomycete of the Nocardia genus. In most cases, nocardiosis manifests as a lung infection or a bone lesion. Due to the nonspecific and mild clinical manifestations of nocardiosis, the establishment of definite diagnosis can be difficult. Read More

    Comment on a Primary Cutaneous of the Hand.
    Open Access Maced J Med Sci 2018 Jan 3;6(1):226-227. Epub 2018 Jan 3.
    Department of Micrology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    . are gram-positive, partially acid-fast bacteria which are lives in environmental sources and cause of various infection that called nocardiosis in animals and humans. Identification of this group of bacteria was important due to accurate diagnosis, patient management and prevention of antibiotic resistant among of bacteria. Read More

    Fulminant Nocardiosis Due to a Multidrug-Resistant Isolate in a 12-Year-Old Immunocompetent Child.
    Pediatrics 2018 Feb;141(2)
    Department of General Pediatrics and Infectious Diseases, AP-HP, Necker-Enfants malades University Hospital, Sorbonne Paris Cité, Paris, France;
    Nocardiosis is a rare cause of infection that usually affects immunocompromised adult patients and might not be recognized by pediatricians. We report a fatal case of disseminated nocardiosis in a previously healthy child initially admitted for an abdominal mass with suspicion of a renal malignant tumor. The patient, originating from Mali without any medical history, displayed abdominal pain with progressive altered general status. Read More

    Extensive Cutaneous Botryomycosis With Subsequent Development of Nocardia-Positive Wound Cultures.
    J Cutan Med Surg 2018 Jan 1:1203475418755762. Epub 2018 Jan 1.
    2 Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
    Botryomycosis is a rare, chronic granulomatous infection caused by a response to bacteria, most commonly Staphylococcus aureus. Cutaneous manifestations, such as subcutaneous nodules, nonhealing ulcers, or sinus tracks, typically occur following inoculation of bacteria after trauma. Drainage from the skin lesions may contain yellow grains resembling those seen in actinomycosis and nocardiosis. Read More

    A Rare Cause of Pyogenic Flexor Tenosynovitis: Nocardia nova.
    J Hand Surg Am 2018 Jan 15. Epub 2018 Jan 15.
    Wellspan Medical Group, York, PA. Electronic address:
    Infection complicates approximately 5% of open trigger digit releases. Both superficial and deep infections may occur. We present a unique case of a cactus farmer who underwent an uneventful thumb trigger finger release and subsequently developed pyogenic flexor tenosynovitis and acute carpal tunnel syndrome resulting from Nocardia nova infection. Read More

    Rare Multidrug-Resistant Pulmonary Nocardiosis in AIDS.
    Cureus 2017 Nov 11;9(11):e1839. Epub 2017 Nov 11.
    Department of Infectious Diseases, Creighton University Medical Center.
    Nocardiosis is an opportunistic infection in patients with depressed cell-mediated immunity. Inhalation is the primary route for exposure via dust particles. Patients with acquired immune deficiency syndrome (AIDS) are at increased risk of disseminated disease. Read More

    Current knowledge of nocardiosis in teleost fish.
    J Fish Dis 2018 Mar 17;41(3):413-419. Epub 2018 Jan 17.
    Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.
    Nocardia sp. is the causative agent of nocardiosis, a lethal granulomatous disease of the skin, muscle, and various inner tissues affecting various teleost and shellfish. Four species of Nocardia have been isolated from diseased fish and shellfish, namely Nocardia asteroides, Nocardia seriolae, Nocardia salmonicida and Nocardia crassostreae. Read More

    Pulmonary nocardiosis in a patient with idiopathic CD4 T-lymphocytopenia.
    Respirol Case Rep 2018 Feb 21;6(2):e00283. Epub 2017 Dec 21.
    Department of PulmonologyOakland University William Beaumont HospitalRoyal OakMichiganUSA.
    Idiopathic CD4 T-lymphocytopenia (ICL) is a rare immunodeficiency characterized by low CD4 T-lymphocyte count, which usually manifests with opportunistic infections. Nocardia as an opportunistic pathogen infecting patients with this condition has rarely been reported. Here, we describe the case of a 46-year-old male who presented with lung mass and respiratory and systemic symptoms and was eventually diagnosed with pulmonary nocardiosis. Read More

    Ventilator-dependent pulmonary nocardiosis in a patient with chronic obstructive pulmonary disease.
    Lung India 2018 Jan-Feb;35(1):58-61
    Department of Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA.
    Nocardiosis is a rare infectious disease entity that mostly affects the lungs, brain, or skin of immunocompromised individuals. Recent reports of pulmonary nocardiosis (PN) in patients with chronic obstructive pulmonary disease (COPD) as the only risk factor suggest a possible association between nocardiosis and COPD. Herein, we present a case of ventilator-dependent PN in a patient with a moderate degree of COPD. Read More

    Skin Infections due to Bacteria in Solid Organ Transplant Recipients: A Review.
    Dermatology 2017 10;233(5):358-365. Epub 2018 Jan 10.
    Department of Dermatology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
    Though there is an abundance of information on cutaneous malignancies in transplant recipients, cutaneous infections in solid organ transplant recipients (SOTRs) are underrepresented in the dermatological literature. Our paper provides a comprehensive review of bacterial cutaneous infections within the solid organ transplant population. Cutaneous bacterial infections may lead to significant morbidity and even mortality in this immunosuppressed population. Read More

    Chronic Nocardia cyriacigeorgica Periprosthetic Knee Infection Successfully Treated with a Two-Stage Revision: A Case Report.
    JBJS Case Connect 2017 Oct-Dec;7(4):e74
    Department of Orthopaedic Surgery (M.M.H., J.R.M., I.J.D., and J.A.B.) and Division of Infectious Disease and International Health, Department of Medicine (C.C.M.), University of Virginia, Charlottesville, Virginia.
    Case: We report the successful treatment of a Nocardia cyriacigeorgica periprosthetic joint infection (PJI) that occurred at the site of a total knee arthroplasty. To our knowledge, this organism has not previously been reported in the literature as a cause of PJI. Given the need for a prolonged duration of treatment for this organism (a minimum of 6 to 12 months), modifications to the standard 2-stage revision were made in consultation with infectious-disease specialists. Read More

    Diffuse Nocardial Spinal Subdural Empyema: Diagnostic Dilemma and Treatment Options.
    Cureus 2017 Oct 24;9(10):e1795. Epub 2017 Oct 24.
    Department of Neurosurgery, University of Louisville School of Medicine.
    Nocardiosis of the central nervous system and spine, in particular, is a rare infection with significant morbidity and mortality. Treatment is usually with antibiotics and surgical drainage or biopsy. The authors report a case of a 49-year-old man who presented with chronic lower back pain and paraplegia. Read More

    CT findings of pulmonary nocardiosis: a report of 9 cases.
    J Thorac Dis 2017 Nov;9(11):4785-4790
    Department of Respiratory and Critical Medicine, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen 518020, China.
    Background: Pulmonary nocardiosis often occurs among immunocompromised patients, especially in those with impaired cell immunity related to AIDS and transplant. As the number of patients receiving transplant, the occurrence of pulmonary nocardiosis may also increase. Radiologic characteristics of this entity have not been well documented. Read More

    Disseminated Nocardiosis Associated with Treatment with Infliximab in a Patient with Ulcerative Colitis.
    Am J Case Rep 2017 Dec 21;18:1365-1369. Epub 2017 Dec 21.
    Department of Internal Medicine, Texas Tech University Health Sciences Center at The Permian Basin, Odessa, TX, USA.
    BACKGROUND Opportunistic infections may occur when patients with inflammatory bowel disease (IBD) are treated with tumor necrosis factor (TNF)-alpha inhibitors. With the increasing use of new immunosuppressant drugs, the incidence of opportunistic or atypical infections is also increasing, including with Nocardia spp. A high level of awareness of atypical infections is warranted in immunosuppressed patients. Read More

    Case 249: Intramuscular Mycetoma.
    Radiology 2018 01;286(1):353-359
    From the Departments of Radiodiagnosis (Z.N., N.M.), Plastic Surgery (A.B.), and Microbiology (R.S.K.M.), Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow, Uttar Pradesh, India 226014.
    History A 21-year-old man presented with swelling of the medial aspect of the left thigh of 1-month duration. There was no history of fever or penetrating injury in the left thigh. The patient had undergone renal transplantation 7 years earlier and had been taking immunosuppressants since transplantation. Read More

    An overview of resistance profiles ESKAPE pathogens from 2010-2015 in a tertiary respiratory center in Romania.
    Rom J Morphol Embryol 2017 ;58(3):909-922
    "Marius Nasta" Institute for Pulmonary Medicine, Bucharest, Romania;
    Lower respiratory tract infections (LRTIs) is an umbrella term that covers a wide spectrum of diseases, comprising mild and severe, acute and chronic conditions. A wide spectrum of pathogens can be implicated, from viruses to pyogenic and atypical bacteria. A special place should be reserved for slow growing bacteria (Mycobacteria spp. Read More

    A case of empyema and septic arthritis due to .
    Clin Case Rep 2017 Dec 24;5(12):1976-1979. Epub 2017 Oct 24.
    Department of Respiratory MedicineSaitama Cardiovascular and Respiratory CenterSaitamaJapan.
    Septic arthritis due to sp. should be suspected when a patient with risk factors such as pneumoconiosis or diabetes mellitus develops joint symptoms, especially if the patient has had nocardiosis in other sites. Read More

    Syndrome of Inappropriate Antidiuretic Hormone Secretion Complicating Systemic Nocardiosis in a Renal Transplant Recipient: A Case Report.
    Transplant Proc 2017 Dec;49(10):2368-2371
    Nephrology Department and Renal Transplantation Unit, Laiko Hospital, National and Kapodistrian University of Athens, Greece.
    Background: Infection by Nocardia species is an uncommon cause of severe clinical syndromes, particularly in immunocompromised patients, and solid-organ transplantation is the most common underlying condition. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) has been described thus far in lung and stem cell transplants with systemic nocardiosis.

    Case Report: We report the first case of SIADH in a female elderly renal transplant recipient diagnosed with systemic nocardiosis 2 years after transplantation. Read More

    Dermatological Complications After Solid Organ Transplantation.
    Clin Rev Allergy Immunol 2018 Feb;54(1):185-212
    Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
    Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e. Read More

    In vitro activity of some essential oils alone and in combination against the fish pathogen Nocardia seriolae.
    Pol J Vet Sci 2017 Sep;20(3):559-566
    Microplate resazurin assay was applied to investigate the in vitro activity of four essential oils (EOs); cinnamon (Cinnamomum zeylanicum), thyme (Thymus vulgaris), lemongrass (Cymbopogon flexuosus) and tea tree (Melaleuca alternifolia) oils against 80 clinical isolates of the fish pathogen Nocardia seriolae. The checkerboard test was then used to determine the possible synergistic effect of EOs combination against reference type strains of fish nocardiosis. All tested EOs had antibacterial activity against N. Read More

    Disseminated nocardiosis complicated by multiple brain abscesses and pleural empyema in a young diabetic man: a case report.
    Pathologica 2017 Sep;109(3):140-142
    Unit of Thoracic Surgery, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
    Nocardiosis is a life-threatening infection usually affecting immunocompromised patients. Very rarely it presented with intracranial abscesses and pleuro-parenchymal infections. We herein report a very challenging case of a 34-year-old obese and diabetic man affected by disseminated nocardiosis with multiple brain abscesses and pleural empyema. Read More

    Nocardiosis from 1888 to 2017.
    Microb Pathog 2018 Jan 13;114:369-384. Epub 2017 Nov 13.
    Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:
    The genus Nocardia is an aerobic bacterium, Gram-positive and catalase positive that is in Nocardiaceae family. This bacterium first described by Edmond Nocard in 1888 and is not in human commensal bacteria. To date, nocardiosis incidence is increasing due to increase population growth rate, increase in patients with immune disorder diseases and immunocompromised patients. Read More

    The Complexities of Nocardia Taxonomy and Identification.
    J Clin Microbiol 2018 Jan 26;56(1). Epub 2017 Dec 26.
    Microbiology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
    species are a complex group of organisms considered to belong to the aerobic actinomycetes. Of the validly described species, many have been implicated as the cause of serious human infections, especially in immunocompromised patients. The genus has a complicated taxonomic history; this is especially true for , the type species of the genus and previously the most frequently reported nocardial taxon from human specimens. Read More

    Successful Treatment of Disseminated Nocardiosis Caused by Nocardia veterana in a Dog.
    J Vet Intern Med 2018 Jan 4;32(1):418-422. Epub 2017 Nov 4.
    Department of Medicine & Epidemiology, University of California-Davis, Davis, CA.
    A 5-year-old male castrated Lhasa Apso cross was evaluated for a 1-month history of inappetence, lethargy, gagging, and progressive right thoracic limb lameness. Synovial fluid analysis revealed nonseptic suppurative inflammation, and a diagnosis of immune-mediated polyarthritis (IMPA) was made. After 3 months of treatment with prednisone and later cyclosporine, the dog developed multiple firm cutaneous and subcutaneous masses and a focal mass within the jejunum. Read More

    Transparent Tiger barb Puntius tetrazona, a fish model for in vivo analysis of nocardial infection.
    Vet Microbiol 2017 Nov 5;211:67-73. Epub 2017 Oct 5.
    Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fishery Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, Guangdong, 510380, China. Electronic address:
    Nocardiosis afflicts multiple species of cultured fish, resulting in substantial economic losses to the aquaculture industry, however, lack of detailed knowledge on disease pathogenesis has hampered the development of effective prevention and control strategies. In this study, we injected a green fluorescent protein (GFP)-labeled Nocardia seriolae strain into a transparent mutant strain of Tiger barb (Puntius tetrazona) to monitor tissue pathogen accumulation and tissue damage in vivo, and to clarify the relationship between pathogenic processes and overt symptoms. GFP-labeled bacteria were phagocytized by leukocytes and could proliferate within these cells, which in turn led to leukocyte aggregation, leukocyte death, and granuloma formation. Read More

    Granulomatous Thyroiditis: A Case Report and Literature Review.
    Ann Clin Lab Sci 2017 Sep;47(5):620-624
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
    Background: Granulomatous disease in the thyroid gland has been linked to viral, bacterial and autoimmune etiologies. The most common granulomatous disease of the thyroid is subacute granulomatous thyroiditis, which is presumed to have a viral or post-viral inflammatory cause. Bacterial etiologies include tuberculosis, actinomycosis, and nocardiosis, but are extremely rare. Read More

    Nocardia beijingensis pericarditis presenting with cardiac tamponade: A case report.
    Int J STD AIDS 2018 Apr 23;29(5):515-519. Epub 2017 Oct 23.
    1 Internal Medicine Department, Faculty of Medicine, 26682 Chiang Mai University , Chiang Mai, Thailand.
    We report the first case of Nocardia beijingensis pericarditis in a 32-year-old HIV-infected patient. He presented with cardiac tamponade after failing to respond to treatment for smear-negative pulmonary and pericardial tuberculosis (TB). The pericardial fluid was examined several times before it eventually revealed filamentous branching organisms in Gram and modified acid-fast bacilli stain. Read More

    Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
    Immunity 2017 10;47(4):710-722.e6
    Institute of Immunology and Infection Research, University of Edinburgh, EH9 3FL Edinburgh, UK. Electronic address:
    Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resistance in a T cell receptor (TCR)-independent manner. Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR. This shared signaling complex allowed IL-33 to induce the EGFR-mediated activation of the MAP-kinase signaling pathway and consequently the expression of IL-13. Read More

    Virulence test using nematodes to prescreen species capable of inducing neurodegeneration and behavioral disorders.
    PeerJ 2017 10;5:e3823. Epub 2017 Oct 10.
    UMR CNRS5557, INRA1418 Ecologie Microbienne, Université Lyon 1, VetAgro Sup, Université Claude Bernard (Lyon I), Lyon, France.
    Background: Parkinson's disease (PD) is a disorder characterized by dopaminergic neuron programmed cell death. The etiology of PD remains uncertain-some cases are due to selected genes associated with familial heredity, others are due to environmental exposure to toxic components, but over 90% of cases have a sporadic origin. are Actinobacteria that can cause human diseases like nocardiosis. Read More

    Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis.
    Case Rep Dermatol 2017 May-Aug;9(2):119-129. Epub 2017 Aug 17.
    Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis. Read More

    Mycobacterium grossiae sp. nov., a rapidly growing, scotochromogenic species isolated from human clinical respiratory and blood culture specimens.
    Int J Syst Evol Microbiol 2017 Nov 6;67(11):4345-4351. Epub 2017 Oct 6.
    1​Department of Laboratory Medicine, Yale School of Medicine/Yale-New Haven Hospital, New Haven, CT, USA.
    A previously undescribed, rapidly growing, scotochromogenic species of the genus Mycobacterium (represented by strains PB739 and GK) was isolated from two clinical sources - the sputum of a 76-year-old patient with severe chronic obstructive pulmonary disease, history of tuberculosis exposure and Mycobacterium avium complex isolated years prior; and the blood of a 15-year-old male with B-cell acute lymphoblastic leukaemia status post bone marrow transplant. The isolates grew as dark orange colonies at 25-37 °C after 5 days, sharing features in common with other closely related species. Analysis of the complete 16S rRNA gene sequence (1492 bp) of strain PB739 demonstrated that the isolate shared 98. Read More

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