Search Our Scientific Publications & Authors

Front Pediatr 2019 28;7:107. Epub 2019 Mar 28.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Hershey, PA, United States.

Chronic Granulomatous Disease (CGD) is caused by genetic defects in the phagocyte NADPH oxidase leading to potentially severe infections with catalase positive micro-organisms. With the innate immune system being affected this disease usually presents before the age of 5 years with infections involving the skin, lung, liver or lymphnodes. Infections with specific catalase positive organisms, especially and prompt a workup for CGD in affected patients. Read More

Ann Card Anaesth 2019 Apr-Jun;22(2):221-224

Department of Internal Medicine, Maimonides Medical Center, New York City, USA.

Gordonia is a catalase-positive, aerobic, nocardioform, Gram-positive staining actinomycete that also shows weak acid-fast staining. Several Gordonia species are commonly found in the soil. The bacterium has been isolated from the saliva of domesticated/wild dogs as well. Read More

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):329-331

Department of Infectious Disease and Clinical Microbiology, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Disseminated Nocardia infections occur particularly in immunosuppressed hosts and are most often due to Nocardia farcinica, Nocardia nova, and Nocardia cyriacigeorgica. Here, we report an unusual case of disseminated N. farcinica infection presenting as a paravertebral abscess in a patient with systemic lupus erythematosus. Read More

Australas J Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Infectious Diseases, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Pediatr Transplant 2019 Mar 19:e13392. Epub 2019 Mar 19.

Division of Pediatric Nephrology, Department of Pediatrics, University Florida, Gainesville, Florida.

Nocardia infection after RT is uncommon. The most common modes of exposure are inhalation of dust containing nocardia or contaminated soil/water and surgical instruments. Isolated abdominal nocardiosis following RT has not been reported. Read More

JMM Case Rep 2019 Feb 20;6(2):e005175. Epub 2019 Feb 20.

Departament of Microbiology, University Hospital Marqués de Valdecilla - IDIVAL, Santander, Spain.

Introduction: complex has been associated with infections in both immunocompetent and immunocompromised patients. Infection can be localized or disseminated, affecting skin and soft tissues, the respiratory system, bones and joints, the circulatory system and especially the central nervous system. Ocular infections such as keratitis, scleritis, conjunctivitis, dacryocystitis, orbital cellulitis and endophthalmitis due to spp. Read More

J Dtsch Dermatol Ges 2019 03 18;17(3):327-329. Epub 2019 Mar 18.

Infectious Diseases Research Laboratory, Professor Edgard Santos University Teaching Hospital, Federal University of Bahia, Brazil.

Medicine (Baltimore) 2019 Mar;98(11):e14879

Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC).

Rationale: Nocardia species are not commonly referred as primary infectious entities but rather as opportunistic pathogens. Infectious cases of Nocardia spp. in immunocompetent individuals are rare. Read More

J Fish Dis 2019 May 10;42(5):657-666. Epub 2019 Mar 10.

Shenzhen Research Institute of Guangdong Ocean University, Shenzhen, China.

Nocardia seriolae, a facultative intracellular bacterium, is the main pathogen of fish nocardiosis. Bioinformatic analysis showed that the histone-like DNA-binding protein (HLP) gene of N. seriolae (nshlp) encoded a secreted protein and might target the mitochondria in the host cell. Read More

J Infect Chemother 2019 Mar 7. Epub 2019 Mar 7.

Department of Rheumatology, Iizuka, Japan.

Here, we present a case of disseminated nocardiosis, involving pneumonia, percutaneous abscess, and bacteremia, in a 67-year-old Japanese woman. She had also been treated for rheumatoid arthritis with prednisolone, methotrexate, and tocilizumab (interleukin-6 receptor inhibitor). Based on the 16S rRNA sequence analysis and a blast search, we identified the isolate as Nocardia brasiliensis. Read More

Med Clin (Barc) 2019 Mar 5. Epub 2019 Mar 5.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Virgen Macarena. Departamento de Medicina de la Universidad de Sevilla. Instituto de Biomedicina de Sevilla (IBIS), Sevilla, España.

J Coll Physicians Surg Pak 2019 Mar;29(3):278-280

Department of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Nocardia species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, Nocardia may sometimes causes an infectious disease in immunocompetent hosts. Herein, we report two cases of pulmonary nocardiasis in immunocompetent individuals, whose chest computed tomography (CT) findings mimicked bronchiectasis. Read More

Clin Transplant 2019 Feb 28:e13509. Epub 2019 Feb 28.

Division of Infectious Diseases, Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois.

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of Nocardia infections after solid organ transplantation (SOT). Nocardia infections have increased in the last two decades, likely due to improved detection and identification methods and an expanding immunocompromised population. The risk of developing nocardiosis after transplantation varies with the type of organ transplanted and the immunosuppression regimen used. Read More

Front Immunol 2019 5;10:153. Epub 2019 Feb 5.

Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.

Transcriptome analysis is a powerful tool that enables a deep understanding of complicated physiological pathways, including immune responses. RNA sequencing (RNA-Seq)-based transcriptome analysis and various bioinformatics tools have also been used to study non-model animals, including aquaculture species for which reference genomes are not available. Rapid developments in these techniques have not only accelerated investigations into the process of pathogenic infection and defense strategies in fish, but also used to identify immunity-related genes in fish. Read More

PLoS One 2019 25;14(2):e0211989. Epub 2019 Feb 25.

Research Group on Bacterial Opportunistic Pathogens and Environment, UMR CNRS5557, INRA1418 Écologie Microbienne, Observatoire Français des Nocardioses, Hospices Civils de Lyon, France, Université de Lyon 1, VetAgro Sup, Lyon, France.

Background: Transplant recipients are at risk of pulmonary nocardiosis, a life-threatening opportunistic infection caused by Nocardia species. Given the limitations of conventional diagnostic techniques (i.e. Read More

Trop Med Infect Dis 2019 Feb 12;4(1). Epub 2019 Feb 12.

Department of Medicine, Division of Infectious Diseases, University of Texas Health, San Antonio, TX 78229, USA.

Strongyloidiasis, due to infection with the nematode , affects millions of people in the tropics and subtropics. has a unique auto-infective lifecycle such that it can persist in the human host for decades. In immunosuppressed patients, especially those on corticosteroids, potentially fatal disseminated strongyloidiasis can occur, often with concurrent secondary infections. Read More

Eur J Case Rep Intern Med 2019 3;6(1):000997. Epub 2019 Jan 3.

Unidade Funcional de Medicina 2.1, Hospital de Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Immunosuppressed patients are at greater risk of unusual infections. The authors present the case of a woman with giant-cell arteritis, on oral steroids, who developed cavitating pneumonia due to co-infection with and . Reports of such co-infection are rare in the literature. Read More

Int J Infect Dis 2019 Apr 4;81:97-99. Epub 2019 Feb 4.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

A case of granulomatous hepatitis due to Nocardia is reported here. The case patient was a 63-year-old immunocompetent man who presented with persistent fever, weight loss, and malaise. Radiology suggested an enlarged liver with dense diffuse to multiple tiny micronodular areas of parenchymal involvement, possibly granulomatous. Read More

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan.

We report a case of Nocardia exalbida (N.exalbida)-induced pneumonia in a 70-year old Japanese man with lung cancer and radiation pneumonitis. He initially received doripenem (1. Read More

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):153-155

Department of Pulmonary Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India.

Pulmonary nocardiosis is an uncommon bacterial infection that may lead to severe disease in immunocompromised patients. The disease is rare in immunocompetent patients. Reported cases are few, and the literature is limited because disease recognition is difficult. Read More

Pediatr Pulmonol 2019 Apr 31;54(4):E10-E12. Epub 2019 Jan 31.

Faculty of Medicine, Department of Pediatric Infectious Disease, Gazi University, Ankara, Turkey.

Nocardia spp is a gram-positive aerobic filamentous bacteria that causes pulmonary and systemic infections, especially in patients with immunosuppression or chronic lung diseases. It is rarely reported in children with cystic fibrosis. Macrophage activation syndrome is a life-threatening disease with an excessive inflammatory response usually triggered by infections. Read More

J Infect Public Health 2019 Mar - Apr;12(2):167-170. Epub 2019 Jan 28.

Department of Microbiology, Manipal Academy of Higher Education, Manipal, India.

Nocardia asteroides complex and Nocardia brasiliensis are common etiological agents of disseminated nocardiosis among immunocompromised individuals. Here we reported an uncommon case of disseminated nocardiosis with the involvement of lung, brain, soft tissue & pancreas by a rarely isolated species Nocardia asiatica in a HIV infected individual. Diagnosis was initially misinterpreted as tuberculosis based on the clinical and radiological findings. Read More

Diagn Microbiol Infect Dis 2018 Dec 29. Epub 2018 Dec 29.

Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China. Electronic address:

Nocardia spp. is a pathogen responsible for a variety of clinical infections, ranging from skin and soft tissue infections, to the respiratory tract and central nervous system infections. Its epidemiological characteristics, including species distribution, clinical features, and antimicrobial susceptibility profiles, should be under surveillance for the prevention and treatment of nocardiosis. Read More

Infect Dis Rep 2018 Nov 12;10(3):7804. Epub 2018 Dec 12.

Maluk Timor, Dili, Timor- Leste.

Mycetoma is a neglected tropical disease with an unknown global burden. Although considered endemic to South-east Asia, it has not previously been reported from Timor-Lest. We describe two cases in Timor-Leste, highlighting the challenges surrounding microbiological diagnosis and management shared by many low to middle-income countries. Read More

Int J Infect Dis 2019 Apr 15;81:140-148. Epub 2019 Jan 15.

Centre for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.

Background: Pulmonary nocardiosis (PN) is an uncommon but potentially life-threatening infection. Most of our knowledge on PN is derived from case reports and small case series. Increasing incidence rates of PN have been reported recently. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 01;50(1):53-55

A woman with a past medical history of radiation and chemotherapy for multiple malignancies presented with bilateral, multifocal, elevated chorioretinal lesions associated with vitritis. The differential diagnosis included endogenous endophthalmitis and metastatic disease. Her extensive medical history and ill appearance at presentation in concert with vitritis and subretinal lesions was concerning for endogenous endophthalmitis. Read More

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Pediatric Pulmonology Unit, Department of Pediatrics, Centro Hospitalar São João EPE, Porto, Portugal.

The authors report a case of a lung abscess caused by sp. in a previously healthy adolescent. A 17-year-old young man presented with tonsillitis that did not respond to β-lactamic antibiotic, dyspnoea and thoracic pain. Read More

BMC Vet Res 2019 Jan 3;15(1). Epub 2019 Jan 3.

Department of Microbiology, The University of Hong Kong, Hong Kong, China.

Background: Nocardiosis is often a multi-systemic disease in humans and other mammals. Nocardiosis in birds is uncommon. Laboratory identification of Nocardia to the species level is difficult by traditional phenotypic methods based on biochemical reactions and hydrolysis tests, and is most accurately performed by sequencing multiple gene targets. Read More

Can J Infect Dis Med Microbiol 2018 19;2018:2910198. Epub 2018 Nov 19.

Department of Theoretical and Applied Biology, College of Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

Tuberculosis (TB) is a major cause of human mortality particularly in association with the human immunodeficiency virus (HIV). spp. has emerged as an opportunistic infection especially in HIV patients. Read More

Cutis 2018 Nov;102(5):E13-E15

Department of Dermatology, University of Medicine, Tirana, Albania.

Virus Genes 2019 Apr 17;55(2):257-265. Epub 2018 Dec 17.

Department of Physiology, Anatomy & Microbiology, La Trobe University, Bundoora, VIC, Australia.

We describe here the isolation and characterization of the bacteriophage, NTR1 from activated sludge. This phage is lytic for Nocardia transvalensis, Nocardia brasiliensis and Nocardia farcinica. NTR1 phage has a genome sequence of 65,275 bp in length, and its closest match is to the Skermania piniformis phage SPI1 sharing over 36% of its genome. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13541

Department of Spine Surgery.

Rationale: Nocardial spinal epidural abscess is rare. The diagnosis is often difficult to make and, if delayed, poses a high risk of long-term disability. Nocardial spinal epidural abscess with severe lumbar disc herniation has not previously been reported. Read More

Cureus 2018 Oct 8;10(10):e3427. Epub 2018 Oct 8.

Infectious Disease, Joan C. Edwards School of Medicine - Marshall University, Huntington, USA.

Disseminated Nocardia infections are a rare occurrence that typically occur in immunocompromised hosts. Chronic lymphocytic leukemia (CLL) is a hematologic malignancy which makes patients susceptible to infections through various mechanisms. The treatments for CLL also target immunologic pathways which can contribute to infections. Read More

PLoS Negl Trop Dis 2018 12 10;12(12):e0007019. Epub 2018 Dec 10.

The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

Mycetoma is a neglected tropical disease endemic in tropical and subtropical countries, particularly Sudan. The disease is characterised by the triad of painless subcutaneous mass, multiple sinuses and discharge that contain grains. It is a chronic, debilitating disease most commonly affecting the feet or hands and leads to substantial morbidity, loss of function and even amputation. Read More

Ann Saudi Med 2018 Nov-Dec;38(6):450

Dr. Nishant Nayyar, Department of Radiodiagnosis,, Indira Gandhi Medical College, Shimla, Himachal Pradesh 171001, India, T: 09418026199, nishant23rpgmc@ gmail.com, ORCID: http://orcid. org/0000-0003-2227-9105.

Respirol Case Rep 2019 Feb 28;7(2):e00392. Epub 2018 Nov 28.

Department of Respiratory Medicine National Center for Global Health and Medicine Tokyo Japan.

Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma. A 35-year-old woman with uncontrolled severe asthma despite maximal pharmacological treatment underwent BT and started coughing after the first procedure. One month later, during the second BT procedure, there were white ulcerous lesions on the right B9 bronchus. Read More

Pathology 2018 Dec 25;50(7):753-757. Epub 2018 Oct 25.

SA Pathology, Department of Microbiology and Infectious Diseases, Adelaide, SA, Australia.

Mass spectrometry plays a significant role in the routine identification of micro-organisms and provides the ability to incorporate newly found pathogens into the database in a cost-effective fashion. This work aims to highlight the role of mass spectrometry through improved identification of Nocardia species in a diagnostic clinical microbiology laboratory. Prior to this study we constructed a custom in-house matrix-assisted laser desorption ionisation-time of flight (MALDI-TOF) library for Nocardia isolates consisting of isolates identified to the species level. Read More

Arch Argent Pediatr 2018 Dec;116(6):e744-e748

Servicio de Infectología, Hospital de Niños Sor María Ludovica.

Chronic granulomatous disease is an uncommon primary immunodeficiency due to a defect of the killing activity of phagocytes, caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system. The incidence is 1 in 250 000 live births. It can occur from infancy to adulthood, usually in children under 2 years. Read More

JMM Case Rep 2018 Sep 10;5(9):e005133. Epub 2018 Jan 10.

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: are Gram-positive partially acid-fast bacilli capable of inducing a wide range of infections in patients with immunodeficiency, AIDS, cancer, lupus erythematous and diabetes. was first isolated in 2001 from a patient with chronic bronchitis. Since then, there have been reports on the clinical significance of this organism in patients with bronchitis, brain abscess and lung diseases. Read More

Transpl Infect Dis 2019 Feb 27;21(1):e13025. Epub 2018 Nov 27.

Institute of Human Virology and Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland.

Nocardia species represent a well-recognized yet uncommon cause of opportunistic infections in humans. It most frequently presents as a pulmonary infection with or without central nervous system involvement. It is a very rare cause of spinal abscesses, with only 26 cases reported in the literature. Read More

Medicine (Baltimore) 2018 Oct;97(43):e13023

Rationale: Nocardia species is known as conditional pathogenic bacteria. Among Nocardia species, pulmonary infection caused by Nocardia cyriacigeorgica associated with Aspergillus fumigatus complex lung disease is rarely reported.

Patient Concerns: A 55-year-old female with a history of productive cough with recurrent expectoration for 20 years presented with increasing cough for 12 months. Read More

Med Mal Infect 2018 Dec 28;48(8):516-525. Epub 2018 Jun 28.

Service de médecine interne, centre hospitalier d'Agen-Nérac, route de Villeneuve, 47923 Agen cedex 9, France. Electronic address:

Objectives: To describe the epidemiological, clinical, microbiological, and therapeutic characteristics of Nocardiosis patients treated in a general hospital.

Patients And Methods: Monocentric retrospective analysis of patients presenting with Nocardia-positive biological sample from January 1, 1998 to May 1, 2017.

Results: We identified nine cases of Nocardia infections. Read More

J Glob Antimicrob Resist 2018 Dec 6;15:219-221. Epub 2018 Jul 6.

Aga Khan University Hospital, Karachi, Pakistan.

Objectives: Nocardiosis is an opportunistic infection that can present as cutaneous, pulmonary and/or disseminated disease depending on the host immunity. Treatment choices include trimethoprim/sulfamethoxazole (co-trimoxazole; SXT) and imipenem along with some other antibiotics. The Clinical and Laboratory Standards Institute (CLSI) recommends the broth microdilution (BMD) method to determine antimicrobial susceptibility, however there is a lack of susceptibility data using this method in Pakistan. Read More

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1207-1210

5th Department of Medicine, Division of Infectious Diseases, Evangelismos Hospital, Athens, Greece.

Cutaneous nocardiosis is an infrequent infection which has been increasingly reported in immunocompromised patients. Although trimethoprim-sulfamethoxazole is considered to be the agent of choice for treatment of nocardiosis, newer antimicrobials such as tigecycline have been proven to be effective in vitro, as well. We report the first case of primary cutaneous nocardiosis in a renal transplant recipient having corresponded well to treatment with tigecycline. Read More

Pan Afr Med J 2018;30:131. Epub 2018 Jun 14.

Military Hospital of Instruction Mohammed V, Department of Dermatology, Rabat, Morocco.

Dermatol Ther 2019 01 19;32(1):e12775. Epub 2018 Nov 19.

Department of Dermatology and Laboratory Medicine, Gachon University Gil Medical Center, Incheon, South Korea.

Nocardiosis is a rare localized or systemic suppurative disease caused by the actinomycete Nocardia species. The respiratory tract is the most common site of infection, but primary cutaneous nocardiosis can also be induced by direct inoculation. Nocardiosis is usually reported in immunocompromised patients, such as those with human immunodeficiency virus (HIV) infection, chronic obstructive pulmonary disease, autoimmune diseases, cancer, or in those who have had organ transplantation or corticosteroid administration. Read More

Clin Lab 2018 Oct;64(10):1769-1772

Background: We report a case of a primary cutaneous nocardiosis by autochthonous Nocardia brasiliensis in a Spanish immunocompetent 9-year-old boy.

Methods: N. brasiliensis caused cellulitis showing the patient recovery after drainage and treatment with trimethoprim-sulfamethoxazole. Read More

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Department of Internal Medicine, Oregon Health and Science University, Portland, Oregon, USA.

Nocardiosis is caused by various species of and typically occurs as an opportunistic infection. It frequently disseminates, most often involving the lungs, subcutaneous tissues and central nervous system. It has rarely been reported to affect native heart valves. Read More

Microb Pathog 2019 Jan 11;126:138-148. Epub 2018 Oct 11.

Medical Microbiology and Marine Pharmacology Laboratory, Department of Marine Science, Bharathidasan University, Tiruchirappalli-24, Tamilnadu, India. Electronic address:

The present study was designed to identify the potential bioactive compound from endophytic actinomycetes (EA) Nocardiopsis sp. GRG 2 (KT 235641) against selected extended spectrum beta lactamase (ESBL) producing Pseudomonas aeruginosa (P. aeruginosa) and Klebsiella pneumoniae (K. Read More

BMC Clin Pathol 2018 1;18. Epub 2018 Oct 1.

3Department of Nephrology and Renal Transplantation Medicine, Grande International Hospital, Kathmandu, Nepal.

Background: The cutaneous nocardiosis remains a diagnostic challenge: similar clinical presentations as of cutaneous diseases with different etiology-and the inherent difficulty in cultivating the pathogen.

Case Presentation: Herein, we describe a case of primary cutaneous nocardiosis in a renal transplant recipient; treated with anti-tubercular drugs due to misdiagnosis of cutaneous tuberculosis. On clinical examinations, a few red erythematous papules with erosions and crusting seen, over prior surgery scar of renal transplant. Read More