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    1 OF 109

    Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature.
    Ann Clin Microbiol Antimicrob 2017 Apr 14;16(1):31. Epub 2017 Apr 14.
    MTA-SZTE "Lendület" Fungal Pathogenicity Mechanisms Research Group, Hungarian Academy of Sciences, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary.
    Background: Scedosporium apiospermum is an emerging opportunistic filamentous fungus, which is notorious for its high levels of antifungal-resistance. It is able to cause localized cutaneous or subcutaneous infections in both immunocompromised and immunocompetent persons, pulmonary infections in patients with predisposing pulmonary diseases and invasive mycoses in immunocompromised patients. Subcutaneous infections caused by this fungus frequently show chronic mycetomatous manifestation. Read More

    Detection of high serum levels of β-D-Glucan in disseminated nocardial infection: a case report.
    BMC Infect Dis 2017 Apr 13;17(1):272. Epub 2017 Apr 13.
    Second Department of Internal Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto-machi, Nagasaki, Japan.
    Background: β-D-glucan (BDG) is a helpful diagnostic marker for many invasive fungal infections, but not for nocardiosis. Here, we reported the first case of nocardial infection with high serum level of BDG.

    Case Presentation: A 73-year-old man was hospitalized because of fever, headache, and appetite loss after 10 months of steroid and immunosuppressive therapy for cryptogenic organizing pneumonia. Read More

    Primary cutaneous nocardiosis caused by Nocardia brasiliensis following a wasp sting.
    Clin Exp Dermatol 2017 Apr 10. Epub 2017 Apr 10.
    Department of Dermatology, West China Hospital, Sichuan University No. 37 of Guo Xue Xiang, Chengdu, Sichuan, China.
    We report a case of an 87-year-old woman who presented with painful erythema of her right forearm 10 days after she had been stung by a wasp on her right hand. The lesion had rapidly deteriorated during the week before presentation, and treatment with antibiotics and glucocorticoids did not improve the condition. After careful evaluation, we performed cultures from the lesion aspiration, and morphological and genetic analysis of bacteria cultures confirmed a bacterial infection with Nocardia brasiliensis. Read More

    Surgery of a nocardia lung abscess presenting as a tension pyopneumothorax.
    Asian Cardiovasc Thorac Ann 2017 Jan 1:218492317705286. Epub 2017 Jan 1.
    Department of Thoracic Surgery, Nishi-Kobe Medical Center, Hyogo, Japan.
    While some cases of nocardial pneumonia develop secondary empyema, tension pyopneumothorax is a very rare and lethal complication. A 74-year-old man who exhibited thrombocytopenia during steroid therapy for autoimmune hepatitis, presented to our department with a nocardial tension pyopneumothorax. He underwent a left lower lobectomy after chest drainage, and was discharged without any complication other than reoperation to remove a postoperative hematoma. Read More

    Nocardiosis in freshwater reared Chinook salmon (Oncorhynchus tshawytscha).
    N Z Vet J 2017 Apr 26:1-5. Epub 2017 Apr 26.
    a Animal Health Laboratory , Ministry for Primary Industries , 66 Ward Street, Upper Hutt , New Zealand.
    Case History: An investigation was conducted to identify the cause of mortalities in freshwater reared Chinook salmon (Oncorhynchus tshawytscha). Mortalities occurred in juvenile salmon, at a salmon rearing facility in the South Island of New Zealand. The affected fish were from a pen inside the facility with no surrounding pens or other year classes affected. Read More

    Severe pneumonia due to Nocardia otitidiscaviarum identified by mass spectroscopy in a cotton farmer: A case report and literature review.
    Medicine (Baltimore) 2017 Mar;96(13):e6526
    aDepartment of Nephrology bDepartment of Respiratory and Critical Care Medicine cDepartment of Laboratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.
    Rationale: Nocardia species are aerobic saprophytic bacilli. Among Nocardia species, Nocardia otitidiscaviarum (N otitidiscaviarum) is rarely reported in pulmonary infection.

    Patient Concerns: We reported a case of N otitidiscaviarum pneumonia in a cotton farmer. Read More

    Successful treatment of pulmonary nocardiosis with fluoroquinolone in bronchial asthma and bronchiectasis.
    Respirol Case Rep 2017 May 26;5(3):e00229. Epub 2017 Mar 26.
    Division of Haematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.
    A 72-year-old Japanese woman was admitted at Saga University Hospital for fever, malaise, and productive cough. Six years ago, she had been diagnosed with bronchial asthma and was treated with inhaled corticosteroids. Chest radiograph and computed tomography on admission showed infiltrates in the right middle lobe, a mass lesion in the left lower lobe, and bronchiectasis in both lower lobes. Read More

    Nocardia brasiliensis Infection Complicating Cryptogenic Organizing Pneumonia.
    Case Rep Pulmonol 2017 28;2017:9567175. Epub 2017 Feb 28.
    Division of Pulmonary, Allergy and Sleep Medicine, Mayo Clinic, Jacksonville, FL, USA.
    Pulmonary nocardiosis is a severe and uncommon opportunistic infection caused by Nocardia species. We present a patient with cryptogenic organizing pneumonia who was receiving long-term immunosuppressive therapy, whose treatment course was complicated by cutaneous and pulmonary nocardiosis. Tissue cultures confirmed Nocardia brasiliensis. Read More

    First case report of pulmonary nocardiosis caused by Nocardia mexicana.
    JMM Case Rep 2016 Aug 30;3(4):e005054. Epub 2016 Aug 30.
    Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuoku, Chiba City, Chiba, 260-8673, Japan.
    Introduction: Nocardia species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, Nocardia species may sometimes cause an infection disease in immunocompetent hosts. Nocardia mexicana infections are the least common and are very rare. Read More

    Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses.
    Int J Infect Dis 2017 Mar 22;59:25-28. Epub 2017 Mar 22.
    Department of Internal Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the Netherlands. Electronic address:
    Despite advances in medical care, mortality due to cerebral Nocardia abscesses remains unacceptably high. The case of a typical immunocompromised patient, who deteriorated clinically despite optimal antimicrobial treatment, is reported here. Adjuvant immunotherapy with interferon-gamma resulted in partial restoration of the immune response and a corresponding clinical and radiographic recovery. Read More

    Outcome and treatment of nocardiosis after solid organ transplantation: new insights from a European study.
    Clin Infect Dis 2017 Feb 4. Epub 2017 Feb 4.
    Division of Infectious Diseases, CUB-Erasme, Université Libre de Bruxelles, Brussels, Belgium.
    Background: Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with one-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days).

    Methods: We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014. Read More

    Endogenous Nocardial Endophthalmitis in an Immunosuppressed Patient: A Serious Warning of an Underlying Life Threatening and Blinding Disorder.
    J Ophthalmic Vis Res 2017 Jan-Mar;12(1):113-116
    Department of Ophthalmology, Army Hospital Research and Referral, Delhi Cantonment, India.
    Purpose: To report a case of bilateral endogenous nocardial endophthalmitis with central nervous system involvement in an immunocompromised individual with an extremely poor outcome.

    Case Report: A 35-year-old man with a history of long-term, prescribed oral steroid use for membranoproliferative glomerulonephritis presented with profound bilateral vision loss. Patient's diagnosis of bilateral endogenous nocardial endophthalmitis was delayed. Read More

    Pulmonary Nocardia beijingensis infection associated with the use of alemtuzumab in a patient with multiple sclerosis.
    Mult Scler 2017 May 1;23(6):872-874. Epub 2017 Feb 1.
    Department of Internal Medicine, UAB School of Medicine, Huntsville, AL, USA.
    Nocardia is a Gram-positive aerobic pathogen that usually affects immunocompromised patients. We report a case of pulmonary infection caused by a rare Nocardia species, Nocardia beijingensis, in a 50-year-old woman who had received alemtuzumab for the treatment of her multiple sclerosis. The invasive pulmonary infection was successfully treated with meropenem. Read More

    Cloning, Expression, Invasion, and Immunological Reactivity of a Mammalian Cell Entry Protein Encoded by the mce1 Operon of Nocardia farcinica.
    Front Microbiol 2017 22;8:281. Epub 2017 Feb 22.
    State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing, China.
    Bacterial mammalian cell entry (Mce) proteins have been implicated in pathogen invasion of mammalian host cells. The aim of this study was to examine the invasion-conferring ability of mce1E operon-encoded proteins, in vivo expression of Mce1E in cells from infected mice and rabbits, and Mce1E immunogenicity. Nocardia farcinica mce1E was cloned into pet30a(+) vectors, expressed in Escherichia coli, and purified. Read More

    Analysis of the complete genome sequence of Nocardia seriolae UTF1, the causative agent of fish nocardiosis: The first reference genome sequence of the fish pathogenic Nocardia species.
    PLoS One 2017 3;12(3):e0173198. Epub 2017 Mar 3.
    Research Center for Bioinformatics and Biosciences, National Research Institute of Fisheries Science, Japan Fisheries Research and Education Agency, Yokohama, Kanagawa, Japan.
    Nocardiosis caused by Nocardia seriolae is one of the major threats in the aquaculture of Seriola species (yellowtail; S. quinqueradiata, amberjack; S. dumerili and kingfish; S. Read More

    Susceptibility profiles of Nocardia spp. to antimicrobial and antituberculotic agents detected by a microplate Alamar Blue assay.
    Sci Rep 2017 Mar 2;7:43660. Epub 2017 Mar 2.
    State Key Laboratory for Infectious Disease Prevention and Control and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing 102206, China.
    Nocardia species are ubiquitous in natural environments and can cause nocardiosis. Trimethoprim-sulfamethoxazole has long been the monotherapy treatment of choice, but resistance to this treatment has recently emerged. In this study, we used microplate Alamar Blue assays to determine the antimicrobial susceptibility patterns of 65 standard Nocardia isolates, including 28 type strains and 20 clinical Nocardia isolates, to 32 antimicrobial agents, including 13 little studied drugs. Read More

    Increasing Nocardia Incidence Associated with Bronchiectasis at a Tertiary Care Center.
    Ann Am Thorac Soc 2017 Mar;14(3):347-354
    2 Division of Infectious Diseases and International Health, Department of Medicine.
    Rationale: Nocardia is a genus of pathogens that most commonly afflict immunocompromised hosts but may be an emerging infection among persons with bronchiectasis.

    Objectives: To examine the epidemiology and clinical presentation of adult patients with Nocardia and bronchiectasis relative to other patient groups.

    Methods: We examined a retrospectively assembled cohort of adults at Duke University Hospital in Durham, North Carolina with at least one positive culture from a bodily fluid or tissue specimen for Nocardia between January 1996 and December 2013. Read More

    Myelosuppression-sparing treatment of central nervous system nocardiosis in a multiple myeloma patient utilizing a tedizolid-based regimen: a case report.
    Int J Antimicrob Agents 2017 Apr 8;49(4):488-492. Epub 2017 Feb 8.
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB 6153B, Cincinnati, OH 45267, USA. Electronic address:
    Central nervous system (CNS) nocardiosis is a recognised opportunistic infection in immunocompromised patients. Treatment involves prolonged institution of antibiotics, making oral agents a convenient and desired option. Unfortunately, devising an effective, well-tolerated antimicrobial for the duration required to treat CNS nocardiosis is challenging owing to treatment intolerance and toxicities. Read More

    [Pulmonary co-infection due to Nocardia cyriacigeorgica and Aspergillus fumigatus].
    Rev Esp Quimioter 2017 Apr 8;30(2):123-126. Epub 2017 Feb 8.
    Rocío Trastoy, Servicio de Microbiología y Parasitología. Complejo Hospitalario Universitario de Santiago de Compostela. Travesía de Choupana, s/n, 15706 Santiago de Compostela, A Coruña, Spain.
    Objective: Pulmonary nocardiosis is an uncommon pulmonary infection caused by aerobic gram-positive bacteria of the genus Nocardia. Nocardia sp. are environmental organisms spread worldwide. Read More

    Tuberculosis 'The Great Imitator': A usual disease with unusual presentations.
    Indian J Tuberc 2017 Jan 4;64(1):54-59. Epub 2016 Jul 4.
    Lecturer, Dept. of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
    Background: A number of infectious diseases have been referred to by the phrase 'The Great Imitator', of which the oldest is syphilis; others include Lyme disease, nocardiosis, etc. Tuberculosis has been described as the second great imitator as it can imitate various other disease processes. An awareness of the atypical clinical manifestations of tuberculosis is important, especially in regions where tuberculosis continues to be a major public health problem, such as India. Read More

    Disseminated Nocardiosis in renal transplant recipient under therapy for pulmonary tuberculosis: a case report.
    BMC Res Notes 2017 Feb 3;10(1):83. Epub 2017 Feb 3.
    Department of Microbiology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
    Background: Nocardiosis is an opportunistic infection in a patient with underlying immune suppression and organ transplant. Clinical syndromes are varied and ranges from pulmonary, disseminated, cutaneous along with central nervous system involvement.

    Case Presentation: Herein, we report a rare case of disseminated pulmonary nocardiosis with cerebral manifestation in a 66 year-old-Nepali farmer; with a history of renal transplantation and undergoing therapy for pulmonary tuberculosis. Read More

    Nocardia liver abscess post liver transplantation-A rare presentation.
    Transpl Infect Dis 2017 Apr 6;19(2). Epub 2017 Mar 6.
    Department of Liver Disease and Transplantation, Global Health City, Chennai, India.
    Nocardiosis is usually a disseminated disease seen in immunocompromised individuals. We herein present a rare case of isolated Nocardia liver abscess post liver transplantation. The patient responded well to treatment and is on long-term antibiotics for Nocardia infection. Read More

    A case of central nervous system nocardiosis in a patient with lupus treated with belimumab.
    Eur J Rheumatol 2016 Dec 1;3(4):188-190. Epub 2016 Dec 1.
    Department of Rheumatology, Medstar Washington Hospital Center, Washington, USA; Department of Clinical Medicine, Georgetown University Medical, Center, Washington, USA.
    Belimumab was approved by the United States Food and Drug Administration in March 2011 as the first biological agent for treating active systemic lupus erythematosus (SLE). To the best of our knowledge, this is the first case report regarding a patient with SLE treated with belimumab who was diagnosed with central nervous system nocardiosis. Read More

    First case of Nocardia amamiensis pulmonary infection in Mexico.
    New Microbes New Infect 2017 Mar 9;16:1-2. Epub 2016 Dec 9.
    Department of Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
    We report a case of Nocardia amamiensis pulmonary infection in a 43-year-old immunocompromised woman. The patient was treated with imipenem/cilastatin and trimethoprim/sulfamethoxazole and had a favourable outcome. It is important that laboratories perform species identification to understand the epidemiology and susceptibility patterns of the different Nocardia spp. Read More

    Pulmonary nocardiosis caused by Nocardia otitidiscaviarum in an adult asthmatic female patient: The presence of acid-fast branching filaments is always significant.
    S Afr Med J 2016 Dec 21;107(1):43-45. Epub 2016 Dec 21.
    Department of Preventive Medicine, Faculty of Veterinary Medicine, University of Khartoum, Sudan.
    We report a case of pulmonary nocardiosis in a 41-year-old asthma patient. Chest radiographs showed bilateral air space and consolidations.Acid-fast branching filaments were demonstrated in sputum, and the grown organism was identified phenotypically and confirmed using16S rDNA sequencing (accession no. Read More

    Systemic nocardiosis in a dog caused by Nocardia cyriacigeorgica.
    BMC Vet Res 2017 Jan 21;13(1):30. Epub 2017 Jan 21.
    Department of Pathology, School of Veterinary Medicine, Firat University, 23 200, Elazig, Turkey.
    Background: Systemic nocardiosis due to Nocardia cyriacigeorgica has not been reported in dogs.

    Case Presentation: Light and electron microscopy, microbiological culture and molecular identification (PCR) were used to diagnose systemic nocardiosis caused by Nocardia cyriacigeorgica in a 3-month-old husky dog. The postmortem changes included multifocal to coalescing, sharply circumscribed pyogranulomatous inflammation and abscess formation in lungs, liver, myocardium, spleen, kidneys, brain, and hilar lymph nodes. Read More

    Nocardiosis in ectopic ACTH syndrome: A case report and review of 11 cases from the literature.
    Exp Ther Med 2016 Dec 27;12(6):3626-3632. Epub 2016 Oct 27.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China; The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.
    Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) associated with nocardiosis is rare, and little information is available regarding its clinical characteristics. In this study, the case of a 35-year-old male patient who showed significant cushingoid features and had a cough with yellow phlegm for 1 month is described. Pulmonary computed tomography (CT) scanning and (18)F-fluorodeoxyglucose positron emission tomography combined with CT identified two different lesions in the mediastinum and pulmonary region, respectively. Read More

    Molecular analysis and species diversity of Nocardia in the hospital environment in a developing country, a potential health hazard.
    J Med Microbiol 2017 Mar 23;66(3):334-341. Epub 2017 Mar 23.
    2​Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Purpose: Despite hundreds of reports on the isolation of Nocardia from clinical samples, the presence and diversity of Nocardia species that are capable of survival in a harsh and adverse condition, such as a hospital environment, have not been comprehensively studied. The aim of this study was to assess Nocardia species diversity in a hospital environment to provide a better insight into their potential threat as a reservoir for the development of nosocomial infections.

    Methodology: A total of 90 samples of hospital water, dust and soil, collected from 30 hospitals, were analysed for the presence of Nocardia using standard protocols for isolation and characterization of the isolates. Read More

    Nocardiosis in the south of France over a 10-years period, 2004-2014.
    Int J Infect Dis 2017 Apr 11;57:13-20. Epub 2017 Jan 11.
    Department of Nephrology, AP-HM, Aix-Marseille University, Hôpital de la Conception, 147,boulevard Baille, 13385 Marseille cedex 5, France. Electronic address:
    Background: Nocardiosis is a rare disease with polymorphic presentations. The epidemiology and clinical presentation could change with the increasing number of immunocompromised patients.

    Methods: The medical records and microbiological data of patients affected by nocardiosis and treated at the university hospitals of Marseille between 2004 and 2014 were analyzed retrospectively. Read More

    Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.
    Clin Infect Dis 2017 Apr;64(7):902-911
    Duke Program for Infection Prevention and Healthcare Epidemiology, Duke University Hospital, Durham, North Carolina.
    Background: Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital.

    Methods: Case patients had recent hospital exposure and laboratory-confirmed colonization or infection with M. Read More

    First reported case of disseminated Nocardia kroppenstedtii sp nov. infection presenting with brain abscess and endocarditis in an immunocompromised patient with mantle cell lymphoma: challenges in diagnosis and treatment.
    BMJ Case Rep 2017 Jan 6;2017. Epub 2017 Jan 6.
    Department of Internal Medicine, University of Arizona, Tucson, Arizona, USA.
    A 72-year-old man with a history of blastoid variant stage IV relapsed refractory mantle cell lymphoma presented with new central nervous system (CNS) symptoms. Brain imaging was positive for rim-enhancing lesions along with a mitral valve mass on the echocardiogram. It was a challenge to establish the exact aetiology of these lesions in this patient. Read More

    Fatal cases of disseminated nocardiosis: challenges to physicians and clinical microbiologists - Case report.
    Acta Microbiol Immunol Hung 2016 Dec;63(4):405-410
    3 Institute of Clinical Microbiology, University of Szeged , Szeged, Hungary.
    Despite the development in the identification of Nocardia spp., common challenges exist in the laboratory diagnosis and management of nocardiosis. We report two cases of disseminated nocardiosis in a patient with hematologic disorder and in a patient with systemic lupus erythematosus, where the cooperation between various specialists was essential to set up the adequate diagnosis of disseminated nocardiosis. Read More

    Epidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain.
    J Antimicrob Chemother 2017 Mar;72(3):754-761
    Objectives: The aims of this study were to explore the clinical distribution, by species, of the genus Nocardia and to assess the antimicrobial susceptibilities of the 10 most prevalent species identified in Spain.

    Methods: Over a 10 year period (2005-14), 1119 Nocardia strains were molecularly identified and subjected to the Etest. The distribution and resistance trends over the sub-periods 2005-09 and 2010-14 were also examined. Read More

    Nocardiosis in the Tropical Northern Territory of Australia, 1997-2014.
    Open Forum Infect Dis 2016 Oct 8;3(4):ofw208. Epub 2016 Dec 8.
    Department of Infectious Diseases and; Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.
    Background: Nocardia is an opportunistic pathogen that can cause life-threatening disease. We aimed to characterize the epidemiological, microbiological, and clinical features of nocardiosis in the tropical north of Australia.

    Methods: We conducted a retrospective cohort study of nocardiosis diagnosed between 1997 and 2014. Read More

    Successful Short-Term Intravenous Treatment of Disseminated Nocardia farcinica Infection with Severe Hyponatremia After Kidney Transplantation: A Case Report.
    Transplant Proc 2016 Nov;48(9):3115-3119
    Division of Nephrology, Medizinische Klinik I, University of Würzburg, Würzburg, Germany.
    Background: Nocardia is a genus of gram-positive Actinomycetes that are ubiquitous in decaying organic material, soil, and water. Some Nocardia species can infect humans, mainly by airborne transmission. Several reports describe disseminated infections, which are rare and mostly affect strongly immunocompromised patients because intact T-cell-mediated immunity is the major protective mechanism. Read More

    Fusarium species causing eumycetoma: Report of two cases and comprehensive review of the literature.
    Mycoses 2017 Mar 7;60(3):204-212. Epub 2016 Dec 7.
    Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
    Recently, mycetoma was added to the World Health Organization's list of neglected tropical disease priorities. Fusarium as a genus has been reported to cause eumycetoma, but little is known about the species involved in this infection and their identification. In this study, molecular tools were applied to identify Fusarium agents from human eumycetoma cases. Read More

    Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease.
    J Clin Microbiol 2017 Feb 7;55(2):574-584. Epub 2016 Dec 7.
    The Mycobacteria/Nocardia Research Laboratory, Department of Microbiology, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
    Bedaquiline (BDQ), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections that no longer respond to conventional drugs. While investigating the off-label use of BDQ as salvage therapy, seven of 13 patients with Mycobacterium intracellulare lung disease had an initial microbiological response and then relapsed. Whole-genome comparison of pretreatment and relapse isolates of M. Read More

    First Case of Actinomycetoma in France Due to a Novel Nocardia Species, Nocardia boironii sp. nov.
    mSphere 2016 Nov-Dec;1(6). Epub 2016 Nov 23.
    Research Group on Bacterial Opportunistic Pathogens and Environment, UMR 5557, Ecologie Microbienne, French Observatory of Nocardiosis, Université de Lyon, Université de Lyon, CNRS, VetAgro Sup, Lyon, France.
    Bacterial mycetoma is a neglected disease mainly observed in tropical area countries and typically associated with rural conditions, making its presence in developed countries of temperate climate areas rare. However, we report the first case of an autochthonous mycetoma case in continental France that originated from a new Nocardia species. A Gram-positive filamentous bacterium (OFN 14. Read More

    An Unusual Presentation of Nocardiosis in an Allogeneic Transplant Recipient.
    Cureus 2016 Oct 17;8(10):e834. Epub 2016 Oct 17.
    Medicine, Staten Island University Hospital.
    Nocardiosis is a rare cause of opportunistic infection post hematopoietic stem cell transplant (HSCT) occurring in about 0.3% of patients. The risk factors include delayed immune reconstitution, prolonged neutropenia, and graft-versus-host disease. Read More

    Identification of Species of Nontuberculous Mycobacteria Clinical Isolates from 8 Provinces of China.
    Biomed Res Int 2016 2;2016:2153910. Epub 2016 Nov 2.
    State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Pathogenic Biology Institute, University of South China, Hengyang, Hunan 421001, China.
    Pulmonary diseases caused by nontuberculous mycobacteria (NTM) are increasing in incidence and prevalence worldwide. In this study, we identified NTM species of the clinical isolates from 8 provinces in China, in order to preliminarily provide some basic scientific data in the different species and distribution of NTM related to pulmonary disease in China. A total of 523 clinical isolates from patients with tuberculosis (TB) diagnosed clinically from 2005 to 2012 were identified to the species using conventional and molecular methods, including multilocus PCR, rpoB and hsp65 PCR-PRA, hsp65, rpoB, and 16S-23S internal transcribed spacer region sequencing. Read More

    Disseminated nocardiosis caused by Nocardia otitidiscaviarum in an immunocompetent host: A case report and literature review.
    Exp Ther Med 2016 Nov 28;12(5):3339-3346. Epub 2016 Sep 28.
    Department of Respiratory and Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.
    The aim of the present study was to summarize the clinical characteristics of nocardiosis caused by Nocardia otitidiscaviarum in order to improve the knowledge of nocardiosis. A case of dissemination nocardiosis caused by N. otitidiscaviarum in an immunocompetent host is reported and the associated literature reviewed. Read More

    A 58-Year-Old Female with Progressive Cough and Right Shoulder Pain.
    Can J Infect Dis Med Microbiol 2016 31;2016:3049298. Epub 2016 Oct 31.
    Section of Infectious Diseases, Department of Internal Medicine, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
    Cavitary pneumonia in immunocompromised patients is a challenging entity. Establishing accurate diagnosis and starting effective antibiotics are essential steps towards improving outcome. A 58-year-old stem cell transplant patient was admitted to the hospital with necrotizing pneumonia caused by nocardia. Read More

    In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex.
    Antimicrob Agents Chemother 2017 Feb 24;61(2). Epub 2017 Jan 24.
    Mycobacteria/Nocardia Research Laboratory, Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
    We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of ≤0.008 μg/ml, and 102/103 isolates had MICs of ≤0. Read More

    Adolescent with recurrent tuberculosis: Can it be chronic granulomatous disease?
    Indian J Tuberc 2016 Jul 4;63(3):207-209. Epub 2016 Jun 4.
    Pediatric TB Clinic, B.J. Wadia Hospital for Children, Mumbai, India. Electronic address:
    Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder with recurrent bacterial and fungal infections like Staphylococcus aureus, Nocardia spp, Serratia marcescens, Burkholderia cepacia, Salmonella spp. and Aspergillus species. We present a 13-year-old male child who had 3 episodes of tuberculosis (TB) at 5 years, 8 years and 13 years of age, respectively, with no other intercurrent infections and who was diagnosed as CGD at the age of 13 years. Read More

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