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    1 OF 113

    Clinical Course, Outcomes and Complications of Thai Pediatric Pure Type versus Mixed Type Lupus Membranous Nephritis.
    J Med Assoc Thai 2017 Feb;100(2):158-66
    Background: Due to the relative infrequency of lupus membranous nephritis (LMN) compared to other types of lupus nephritis (LN) in pediatric patients, the current literature on pediatric LMN is limited. The knowledge regarding clinical manifestations, outcomes and infectious complications are mainly based on studies in the adult population. Similar to disease expression in SLE, the renal manifestations of LMN are affected by environmental factors and vary among racial and ethnic groups. Read More

    Pulmonary Nocardiosis and Scrub Typhus in an Immunocompromised Host.
    J Glob Infect Dis 2018 Apr-Jun;10(2):108-111
    Department of Microbiology, Apollo Hospitals, Greams Road, Chennai, Tamil Nadu, India.
    Pulmonary infections are not uncommon in patients with an underlying immunocompromised condition. Unusual combination of microorganisms causing concomitant infections among these patients has also been reported. However, certain rare dual occurrences are usually unanticipated as in the case we present here. Read More

    Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy.
    Z Gastroenterol 2018 06 11;56(6):569-572. Epub 2018 Jun 11.
    Jena University Hospital, Dept. Internal Medicine IV.
    Nocardiosis is a rare infection caused by ubiquitous soil-born, acid-resistant, Gram-positive bacteria that can be life-threatening in immunocompromised patients. Originally usually diagnosed in HIV-positive patients, only few cases have been reported in patients on immunosuppressive therapy for inflammatory bowel disease or rheumatologic disorders. We present a case of a 32-year-old man who was treated with infliximab, prednisolone, and azathioprine for severe terminal ileitis. Read More

    High Intraspecific Genetic Diversity of , a Pathogen Responsible for Cutaneous Nocardiosis Found in France: Phylogenetic Relationships by Using and Genes.
    Biomed Res Int 2018 20;2018:7314054. Epub 2018 May 20.
    Research Group on "Bacterial Opportunistic Pathogens and Environment", UMR Ecologie Microbienne, CNRS 5557, INRA 1418, UCBL, Université de Lyon, VetAgro Sup, Faculté de Pharmacie, 8 avenue Rockefeller, Lyon, France.
    This study aims at genetic characterization and phylogenetic relationships of focusing by using housekeeping , and genes. is the species responsible for 80% of cases of actinomycetoma, one form of cutaneous nocardiosis which occurs mainly in tropical regions reaching immunocompetent patients in which the disease can lead to amputation. We analyze 36 indigenous cases of that happened in France. Read More

    Can We Kill Two Birds with This Stone? Anti-Pneumocystis Prophylaxis to Prevent Nocardia Infection in Hematopoietic Stem Cell Transplant Recipients.
    Biol Blood Marrow Transplant 2018 Jun 4. Epub 2018 Jun 4.
    Service de Microbiologie, Unité Mobile de Microbiologie Clinique, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
    We read with interest the recent paper by Molina and coworkers, who studied the relationship between anti-Pneumocystis prophylaxis and Nocardia infections in allogeneic hematopoietic stem cell transplant recipients. The authors concluded that the use of atovaquone may be associated with an increased risk of Nocardia infection after allogeneic hematopoietic stem cell transplantation, as compared with cotrimoxazole. In response, we would like to make three comments. Read More

    Cutaneous nocardiosis by a new pathogenic species: .
    BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.
    Dermatology, Hospital de Braga, Braga, Portugal.
    Nocardiosis is a rare, predominantly opportunistic, suppurative disease caused by bacteria of the order Actinomycetales. There are currently more than 100 species of described, less than half are pathogenic to humans. Cutaneous nocardiosis can be caused by direct inoculation from a contaminated material or by secondary dissemination. Read More

    Nocardia infection over 5 years (2011-2015) in an Italian tertiary care hospital.
    New Microbiol 2018 Apr;41(2):136-140
    Infectious Diseases Section, Diagnostic and Public Health Department, University of Verona, Policlinico "G. B. Rossi", Verona, Italy.
    This study was conducted reviewing clinical records of 14 patients affected by nocardiosis over 5 years in a tertiary care hospital. Nocardia abscessus was responsible for one third of infections, deviating significantly from the results reported by other epidemiological investigations and highlighting the key role of molecular identification tests. Indeed, a precise identification of species is crucial for the determination of antibiotic sensitivity patterns and, consequently, for the choice of antibiotic treatment. Read More

    Endobronchial Ultrasound in Suspected Non-Malignant Mediastinal Lymphadenopathy.
    Pneumologie 2018 May 22. Epub 2018 May 22.
    Department of Respiratory Medicine, Medical School Hannover, Germany.
    Background:  Endobronchial ultrasound (EBUS) bronchoscopy with transbronchial needle aspiration (TBNA) is a well-established tool in mediastinal staging in lung cancer and gains importance in exploration of non-malignant lymphadenopathy. The aim of this study was to evaluate the role of EBUS-TBNA in suspected non-malignant diseases.

    Methods:  A retrospective, single-center, observation analysis of endobronchial ultrasound bronchoscopy procedures was performed in a university medical center between March 2013 and July 2015. Read More

    Disseminated Nocardiosis with retinal abscess in a patient treated for bullous pemphigoid.
    Am J Ophthalmol Case Rep 2018 Jun 24;10:145-147. Epub 2018 Feb 24.
    Kentucky Lions Eye Center, University of Louisville, Louisville, KY, USA, 40202.
    Purpose: To report a case of disseminated Nocardiosis with retinal and intracranial lesions.

    Observations: A 49-year-old woman immunosuppressed because of treatment given for bullous pemphigoid presented with altered mental status and multiple intracranial lesions on imaging. The patient was found to have multiple retinal lesions in both eyes, including a subretinal abscess in the right eye. Read More

    [Cerebral and pulmonary nocardiosis to Nocardia abscessus in an immunocompetent Algerian patient].
    J Mycol Med 2018 May 14. Epub 2018 May 14.
    Laboratoire de parasitologie mycologie médicale, CHU Mustapha d'Alger, place 1(er)-mai, Alger, Algérie.
    Nocardial brain abscess is often occurring in immunocompromised patients. It is uncommon in immunocompetent individuals. Here, the authors describe a case of cerebral and pulmonary nocardiosis mimicking a metastatic tumor in an apparently health 40-year-old Algerian male. Read More

    Idiopathic sterile pyogranuloma in three domestic cats.
    J Small Anim Pract 2018 May 15. Epub 2018 May 15.
    Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
    Pyogranulomatous inflammation has been extensively described in cats, in particular in cases of feline infectious peritonitis and also associated with Mycobacteria, Actinomyces, Nocardia, Rhodococcus and fungal infections. Idiopathic sterile pyogranulomatous dermatitis has also been described. In this case series we describe the clinical presentation, histopathology and outcome of three cases of feline idiopathic sterile steroid-responsive pyogranuloma with different presentation and different locations of the lesion, but with the common feature of having a mass with no superficial skin involvement. Read More

    An Acute Nocardia Infection in a Pediatric Hand.
    J Hand Surg Am 2018 May 11. Epub 2018 May 11.
    Department of Orthopedic Surgery and Rehabilitation, The Children's Hospital, University of Oklahoma Medical Center, Oklahoma City, OK.
    Nocardia species are aerobic gram-positive filamentous organisms that may cause cutaneous or pulmonary disease in humans. Primary cutaneous nocardiosis may manifest as an acute superficial pyogenic infection that can mimic more common organisms such as Staphylococcus or Streptococcus. Acute pyogenic Nocardia infection of the pediatric hand is a rare manifestation of this condition. Read More

    Nodular Lymphangitis (Sporotrichoid Lymphocutaneous Infections). Clues to Differential Diagnosis.
    J Fungi (Basel) 2018 May 9;4(2). Epub 2018 May 9.
    Dermatology Service & Mycology Department, Hospital General de Mexico, "Dr. Eduardo Liceaga", Balmis 148, Colonia Doctores, Ciudad de México 06726, Mexico.
    Nodular lymphangitis, also known as sporotrichoid lymphocutaneous infections, is characterized by suppurative inflammatory nodules along the lymphatic vessels. This manifestation is classic of sporotrichosis, however, other infections such as nocardiosis, atypical mycobacteriosis, leishmaniasis, among others, can also express this clinical pattern. Sporotrichosis, which often occurs in gardeners, remains the most recognized cause of nodular lymphangitis. Read More

    Disseminated nocardiosis caused by Nocardia elegans: a case report and review of the literature.
    Infection 2018 May 8. Epub 2018 May 8.
    Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
    Background: Disseminated nocardiosis is a rare disease mostly occurring in immunocompromised patients.

    Methods: We report a case of disseminated nocardiosis in a diabetic patient with both pulmonary and cutaneous involvement. Nocardia elegans was isolated and identified using the 16s ribosomal RNA gene sequence data. Read More

    Microbiological and clinical data analysis of 32 patients with Nocardia infections in Yantai
    Turk J Med Sci 2018 Apr 30;48(2):366-371. Epub 2018 Apr 30.
    Background/aim: Nocardia is an opportunistic pathogen that mostly affects hosts with immune deficiencies. Recently, the widespread use of immunosuppressive agents and antitumor drugs has led to an increasing number of Nocardia infections being reported. However, it is difficult to confirm this diagnosis owing to the slow growth of the bacterium and its complex resultant clinical manifestations, potentially delaying treatment and increasing mortality. Read More

    Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma.
    PLoS Negl Trop Dis 2018 04 26;12(4):e0006437. Epub 2018 Apr 26.
    Erasmus MC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
    Eumycetoma is a chronic infectious disease characterized by a large subcutaneous mass, often caused by the fungus Madurella mycetomatis. A combination of surgery and prolonged medication is needed to treat this infection with a success rate of only 30%. There is, therefore, an urgent need to find more effective drugs for the treatment of this disease. Read More

    Pathogenic and evolve to resist trimethoprim-sulfamethoxazole by both expected and unexpected pathways.
    Antimicrob Agents Chemother 2018 Apr 23. Epub 2018 Apr 23.
    Department of BioSciences, Rice University, Houston, Texas, USA
    are Gram positive opportunistic pathogens that affect largely immunocompromised patients leading to serious pulmonary or systemic infections. Combination therapy using the folate biosynthesis pathway inhibitors, trimethoprim and sulfamethoxazole (TMP-SMX) is commonly used as an antimicrobial therapy. Not surprisingly, as antibiotic therapies for nocardiosis can extend for many months, resistance to TMP-SMX has emerged. Read More

    Role of FNA and Special Stains in Rapid Cytopathological Diagnosis of Pulmonary Nocardiosis.
    Acta Cytol 2018 18;62(3):178-182. Epub 2018 Apr 18.
    Department of Chest and Pulmonary Medicine, Dayanand Medical College and Hospital, Ludhiana, India.
    Background: Nocardia, a gram-positive aerobic bacillus of the Actinomycetales family, is a significant opportunistic pathogen in immunocompromised individuals. Clinical and radiological features of pulmonary nocardiosis are nonspecific and can be misdiagnosed as tuberculosis, pneumocystis, staphylococcal or fungal infections, or as malignancy. Aspiration cytology with special stains is a quick and effective approach for accurate diagnosis. Read More

    Nocardia infections in the transplanted host.
    Transpl Infect Dis 2018 Apr 18:e12902. Epub 2018 Apr 18.
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
    Background: Nocardia are uncommon pathogens that disproportionately afflict the immunocompromised host. Epidemiology and outcome data of Nocardia infections in transplant recipients are limited.

    Methods: We performed a retrospective chart review of all patients at Duke University Hospital with a history of solid organ transplant (SOT) or hematopoietic cell transplant (HCT) and at least one positive culture for Nocardia between 1996 and 2013. Read More

    A 20-year experience with nocardiosis in solid organ transplant (SOT) recipients in the Southwestern United States: A single-center study.
    Transpl Infect Dis 2018 Apr 18:e12904. Epub 2018 Apr 18.
    Division of Infectious Diseases, Department of Medicine, The University of Arizona, Tucson, AZ, USA.
    Background: Nocardiosis is a life-threatening opportunistic infection. Solid organ transplant (SOT) recipients are at higher risk (incidence 0.04%-3. Read More

    spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid.
    Case Rep Infect Dis 2018 30;2018:1749691. Epub 2018 Jan 30.
    Wright State University Boonshoft School of Medicine, Weber CHE 2nd Floor, 128 Apple St., Dayton, OH 45419, USA.
    We describe a rare infection with spp. ( species identification based on high-performance liquid chromatography analysis) in a 68-year-old renal transplant recipient. He presented with pneumonia complicated by hypoxic respiratory failure. Read More

    Efficacy of recombinant protein vaccines for protection against Nocardia seriolae infection in the largemouth bass Micropterus salmoides.
    Fish Shellfish Immunol 2018 Jul 14;78:35-41. Epub 2018 Apr 14.
    Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, No. 1 Shuefu Road, Neipu, Pingtung 91201, Taiwan, ROC; Research Center for Animal Biologics, National Pingtung University of Science and Technology, No. 1 Shuefu Road, Neipu, Pingtung 91201, Taiwan, ROC. Electronic address:
    A reverse vaccinology-based survey of potent antigens associated with fish nocardiosis was conducted using the largemouth bass, Micropterus salmoides, with an aim to develop subunit vaccines. The antigens selected from the virulent strain Nocardia seriolae 961113 include the gene products of NGL2579 (GAPDH), NGL5701 (MMP), NGL4377 (OCTase), NGL4486 (ABC transporter), NGL3372 (LLE), NGL3388 (GHf10), NGL6627 (Antigen-85), NGL6696 (Esterase), and NGL6936 (CBP). These antigens were heterologously expressed in E. Read More

    Adjuvant effect in aquaculture fish of cell-wall glycolipids isolated from acid-fast bacteria.
    Dev Comp Immunol 2018 Aug 14;85:142-149. Epub 2018 Apr 14.
    The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24 Korimoto, Kagoshima, 890-8580, Japan; Faculty of Fisheries, Kagoshima University, 4-50-20 Shimoarata, Kagoshima, 890-0056, Japan. Electronic address:
    Mycobacteriosis and nocardiosis in cultured fish caused by infections with acid-fast bacteria, are responsible for large economic losses globally. In this study, we suggest a novel adjuvant using glycolipids that activates host immune systems. The immune response to glycolipids stimulation was investigated using ginbuna crucian carp. Read More

    Mycetomas: an epidemiological, etiological, clinical, laboratory and therapeutic review.
    An Bras Dermatol 2018 Jan-Feb;93(1):8-18
    Dermatologic Surgery Clinic and Vitiligo Clinic of the Regional Hospital of Asa Norte (HRAN) - Brasília (FD), Brazil.
    Mycetoma is a chronic suppurative disease of the skin and subcutaneous tissue, characterized by a symptomatic triad: tumor, fistulas and grains. It can be caused by fungi (eumycetoma) and bacteria (actinomycetoma), with similar clinical features. Diagnosis is based on the clinical presentation and identification of the etiological agents in the tissue, by mycological/bacteriological, histopathological and immunohistochemical tests. Read More

    Nocardia choroidal abscess-a Case report with Review of literature.
    Nepal J Ophthalmol 2017 Jul;9(18):187-189
    Introduction: Nocardia is a common cause of corneal infections but is a rare cause of choroidal abscess. We report a rare case of choroidal abscess, secondary to Nocardia and its management.

    Case: We report a case of choroidal abscess secondary to Nocardia asteroides species in an immunocompetent young male diagnosed by culture positivity of vitreous biopsy. Read More

    Pulmonary Reinfection by Nocardia in an Immunocompetent Patient with Bronchiectasis.
    Intern Med 2018 Mar 30. Epub 2018 Mar 30.
    Department of Respiratory Medicine, Aichi Cancer Center Aichi Hospital, Japan.
    Pulmonary reinfection by Nocardia has been rarely reported. We describe a case of pulmonary reinfection by Nocardia in an immunocompetent patient. An 82-year-old immunocompetent woman with bronchiectasis presented with exacerbation of cough. Read More

    Bacterial pneumonia in kidney transplant recipients.
    Respir Med 2018 Apr 6;137:89-94. Epub 2018 Mar 6.
    Division of Nephrology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium. Electronic address:
    Bacterial pathogens are the most frequent cause of pneumonia after transplantation. Early after transplantation, recipients are at higher risk for nosocomial infections. The most commonly encountered pathogens during this period are gram-negative bacilli (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa …), but gram-positive coccus such as Staphylococcus aureus or Streptococcus pneumoniae and anaerobic bacteria can also be found. Read More

    Primary Infection Causing a Fluorodeoxyglucose-Avid Right Renal Mass in a Redo Lung Transplant Recipient.
    Case Rep Transplant 2018 7;2018:9752860. Epub 2018 Feb 7.
    Department of Pulmonary Medicine, Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
    Immunosuppression after lung transplantation may increase susceptibility to opportunistic infection and is associated with early and delayed deaths in lung transplant recipients. Factors that may predispose lung transplant recipients to opportunistic bacterial and fungal infections include prolonged corticosteroid use, renal impairment, treatment of acute rejection, and post-transplant diabetes mellitus. We present a unique case of a 63-year-old woman with diabetes mellitus who underwent redo lung transplantation. Read More

    Clinical Assessment of a Nocardia PCR-Based Assay for Diagnosis of Nocardiosis.
    J Clin Microbiol 2018 Jun 25;56(6). Epub 2018 May 25.
    Université Paris Descartes, Sorbonne Paris Cité, AP-HP, Hôpital Necker Enfants Malades, Centre d'Infectiologie Necker-Pasteur and Institut Imagine, Paris, France
    The diagnosis of nocardiosis, a severe opportunistic infection, is challenging. We assessed the specificity and sensitivity of a 16S rRNA PCR-based assay performed on clinical samples. In this multicenter study (January 2014 to April 2015), patients who were admitted to three hospitals and had an underlying condition favoring nocardiosis, clinical and radiological signs consistent with nocardiosis, and a PCR assay result for a clinical sample were included. Read More

    Increased Incidence of Nocardial Infections in an Era of Atovaquone Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplant Recipients.
    Biol Blood Marrow Transplant 2018 Mar 16. Epub 2018 Mar 16.
    David Geffen School of Medicine, University of California, Los Angeles, California; Division of Hematology-Oncology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California.
    Nocardial infections have been rare after allogeneic hematopoietic stem cell transplantation (HSCT). We report 10 recent cases of late-onset nocardiosis (median time of onset of 508 days after transplantation) primarily in patients on high doses of corticosteroids for graft-versus-host disease. All 10 patients had pulmonary infection caused by Nocardia species susceptible to trimethoprim-sulfamethoxazole (TMP-SMX). Read More

    Relationship between the duration of trimethoprim/sulfamethoxazole treatment and the clinical outcome of pulmonary nocardiosis.
    Respir Investig 2018 Mar 22;56(2):166-172. Epub 2018 Feb 22.
    Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Saga Prefecture 849-8501, Japan. Electronic address:
    Background: Despite treatment, pulmonary nocardiosis, which is a rare opportunistic disease caused by Nocardia species, has poor clinical outcomes including recurrence and death. Currently, the treatment regimen and duration for pulmonary nocardiosis are not fully understood. The present study aimed to clarify the factors related to the clinical outcome of pulmonary nocardiosis. Read More

    Pulmonary Nocardiosis: Unusual Presentation in Intensive Care Unit.
    Indian J Crit Care Med 2018 Feb;22(2):125-127
    Department of Critical Care Medicine, Regency Hospital, Kanpur, Uttar Pradesh, India.
    Pulmonary nocardiosis is a rare disease, which mainly affects immunocompromised hosts such as uncontrolled diabetics; HIV patients; and patients on immunosuppressive therapies such as anticancer drugs, systemic steroids, and transplant recipients. The diagnosis is often missed and delayed, resulting in inappropriate treatment and thus higher mortality. We are reporting a case of pulmonary nocardiosis with acute presentation in an immune-competent host, who presented with community-acquired pneumonia to the Intensive Care Unit. Read More

    Rare case of osteomyelitis of tibial shaft caused by Nocardia cyriacigeorgica.
    Folia Microbiol (Praha) 2018 Jul 5;63(4):525-532. Epub 2018 Mar 5.
    Department of Orthopaedics, First Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Úvalu 84, 150 06, Prague 5, Czech Republic.
    Nocardiosis is a rare infection caused by the aerobic actinomycete of the Nocardia genus. In most cases, nocardiosis manifests as a lung infection or a bone lesion. Due to the nonspecific and mild clinical manifestations of nocardiosis, the establishment of definite diagnosis can be difficult. Read More

    Comment on a Primary Cutaneous of the Hand.
    Open Access Maced J Med Sci 2018 Jan 3;6(1):226-227. Epub 2018 Jan 3.
    Department of Micrology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    . are gram-positive, partially acid-fast bacteria which are lives in environmental sources and cause of various infection that called nocardiosis in animals and humans. Identification of this group of bacteria was important due to accurate diagnosis, patient management and prevention of antibiotic resistant among of bacteria. Read More

    Fulminant Nocardiosis Due to a Multidrug-Resistant Isolate in a 12-Year-Old Immunocompetent Child.
    Pediatrics 2018 Feb;141(2)
    Department of General Pediatrics and Infectious Diseases, AP-HP, Necker-Enfants malades University Hospital, Sorbonne Paris Cité, Paris, France;
    Nocardiosis is a rare cause of infection that usually affects immunocompromised adult patients and might not be recognized by pediatricians. We report a fatal case of disseminated nocardiosis in a previously healthy child initially admitted for an abdominal mass with suspicion of a renal malignant tumor. The patient, originating from Mali without any medical history, displayed abdominal pain with progressive altered general status. Read More

    Extensive Cutaneous Botryomycosis With Subsequent Development of Nocardia-Positive Wound Cultures.
    J Cutan Med Surg 2018 May/Jun;22(3):344-346. Epub 2018 Jan 24.
    2 Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
    Botryomycosis is a rare, chronic granulomatous infection caused by a response to bacteria, most commonly Staphylococcus aureus. Cutaneous manifestations, such as subcutaneous nodules, nonhealing ulcers, or sinus tracks, typically occur following inoculation of bacteria after trauma. Drainage from the skin lesions may contain yellow grains resembling those seen in actinomycosis and nocardiosis. Read More

    A Rare Cause of Pyogenic Flexor Tenosynovitis: Nocardia nova.
    J Hand Surg Am 2018 Jan 15. Epub 2018 Jan 15.
    Wellspan Medical Group, York, PA. Electronic address:
    Infection complicates approximately 5% of open trigger digit releases. Both superficial and deep infections may occur. We present a unique case of a cactus farmer who underwent an uneventful thumb trigger finger release and subsequently developed pyogenic flexor tenosynovitis and acute carpal tunnel syndrome resulting from Nocardia nova infection. Read More

    Rare Multidrug-Resistant Pulmonary Nocardiosis in AIDS.
    Cureus 2017 Nov 11;9(11):e1839. Epub 2017 Nov 11.
    Department of Infectious Diseases, Creighton University Medical Center.
    Nocardiosis is an opportunistic infection in patients with depressed cell-mediated immunity. Inhalation is the primary route for exposure via dust particles. Patients with acquired immune deficiency syndrome (AIDS) are at increased risk of disseminated disease. Read More

    Current knowledge of nocardiosis in teleost fish.
    J Fish Dis 2018 Mar 17;41(3):413-419. Epub 2018 Jan 17.
    Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.
    Nocardia sp. is the causative agent of nocardiosis, a lethal granulomatous disease of the skin, muscle, and various inner tissues affecting various teleost and shellfish. Four species of Nocardia have been isolated from diseased fish and shellfish, namely Nocardia asteroides, Nocardia seriolae, Nocardia salmonicida and Nocardia crassostreae. Read More

    Pulmonary nocardiosis in a patient with idiopathic CD4 T-lymphocytopenia.
    Respirol Case Rep 2018 02 21;6(2):e00283. Epub 2017 Dec 21.
    Department of Pulmonology Oakland University William Beaumont Hospital Royal Oak Michigan USA.
    Idiopathic CD4 T-lymphocytopenia (ICL) is a rare immunodeficiency characterized by low CD4 T-lymphocyte count, which usually manifests with opportunistic infections. Nocardia as an opportunistic pathogen infecting patients with this condition has rarely been reported. Here, we describe the case of a 46-year-old male who presented with lung mass and respiratory and systemic symptoms and was eventually diagnosed with pulmonary nocardiosis. Read More

    Ventilator-dependent pulmonary nocardiosis in a patient with chronic obstructive pulmonary disease.
    Lung India 2018 Jan-Feb;35(1):58-61
    Department of Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA.
    Nocardiosis is a rare infectious disease entity that mostly affects the lungs, brain, or skin of immunocompromised individuals. Recent reports of pulmonary nocardiosis (PN) in patients with chronic obstructive pulmonary disease (COPD) as the only risk factor suggest a possible association between nocardiosis and COPD. Herein, we present a case of ventilator-dependent PN in a patient with a moderate degree of COPD. Read More

    Skin Infections due to Bacteria in Solid Organ Transplant Recipients: A Review.
    Dermatology 2017 10;233(5):358-365. Epub 2018 Jan 10.
    Department of Dermatology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
    Though there is an abundance of information on cutaneous malignancies in transplant recipients, cutaneous infections in solid organ transplant recipients (SOTRs) are underrepresented in the dermatological literature. Our paper provides a comprehensive review of bacterial cutaneous infections within the solid organ transplant population. Cutaneous bacterial infections may lead to significant morbidity and even mortality in this immunosuppressed population. Read More

    Chronic Nocardia cyriacigeorgica Periprosthetic Knee Infection Successfully Treated with a Two-Stage Revision: A Case Report.
    JBJS Case Connect 2017 Oct-Dec;7(4):e74
    Department of Orthopaedic Surgery (M.M.H., J.R.M., I.J.D., and J.A.B.) and Division of Infectious Disease and International Health, Department of Medicine (C.C.M.), University of Virginia, Charlottesville, Virginia.
    Case: We report the successful treatment of a Nocardia cyriacigeorgica periprosthetic joint infection (PJI) that occurred at the site of a total knee arthroplasty. To our knowledge, this organism has not previously been reported in the literature as a cause of PJI. Given the need for a prolonged duration of treatment for this organism (a minimum of 6 to 12 months), modifications to the standard 2-stage revision were made in consultation with infectious-disease specialists. Read More

    Diffuse Nocardial Spinal Subdural Empyema: Diagnostic Dilemma and Treatment Options.
    Cureus 2017 Oct 24;9(10):e1795. Epub 2017 Oct 24.
    Department of Neurosurgery, University of Louisville School of Medicine.
    Nocardiosis of the central nervous system and spine, in particular, is a rare infection with significant morbidity and mortality. Treatment is usually with antibiotics and surgical drainage or biopsy. The authors report a case of a 49-year-old man who presented with chronic lower back pain and paraplegia. Read More

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