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    Fulminant Nocardiosis Due to a Multidrug-Resistant Isolate in a 12-Year-Old Immunocompetent Child.
    Pediatrics 2018 Feb;141(2)
    Department of General Pediatrics and Infectious Diseases, AP-HP, Necker-Enfants malades University Hospital, Sorbonne Paris Cité, Paris, France;
    Nocardiosis is a rare cause of infection that usually affects immunocompromised adult patients and might not be recognized by pediatricians. We report a fatal case of disseminated nocardiosis in a previously healthy child initially admitted for an abdominal mass with suspicion of a renal malignant tumor. The patient, originating from Mali without any medical history, displayed abdominal pain with progressive altered general status. Read More

    Extensive Cutaneous Botryomycosis With Subsequent Development of Nocardia-Positive Wound Cultures.
    J Cutan Med Surg 2018 Jan 1:1203475418755762. Epub 2018 Jan 1.
    2 Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
    Botryomycosis is a rare, chronic granulomatous infection caused by a response to bacteria, most commonly Staphylococcus aureus. Cutaneous manifestations, such as subcutaneous nodules, nonhealing ulcers, or sinus tracks, typically occur following inoculation of bacteria after trauma. Drainage from the skin lesions may contain yellow grains resembling those seen in actinomycosis and nocardiosis. Read More

    A Rare Cause of Pyogenic Flexor Tenosynovitis: Nocardia nova.
    J Hand Surg Am 2018 Jan 15. Epub 2018 Jan 15.
    Wellspan Medical Group, York, PA. Electronic address:
    Infection complicates approximately 5% of open trigger digit releases. Both superficial and deep infections may occur. We present a unique case of a cactus farmer who underwent an uneventful thumb trigger finger release and subsequently developed pyogenic flexor tenosynovitis and acute carpal tunnel syndrome resulting from Nocardia nova infection. Read More

    Rare Multidrug-Resistant Pulmonary Nocardiosis in AIDS.
    Cureus 2017 Nov 11;9(11):e1839. Epub 2017 Nov 11.
    Department of Infectious Diseases, Creighton University Medical Center.
    Nocardiosis is an opportunistic infection in patients with depressed cell-mediated immunity. Inhalation is the primary route for exposure via dust particles. Patients with acquired immune deficiency syndrome (AIDS) are at increased risk of disseminated disease. Read More

    Current knowledge of nocardiosis in teleost fish.
    J Fish Dis 2018 Mar 17;41(3):413-419. Epub 2018 Jan 17.
    Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.
    Nocardia sp. is the causative agent of nocardiosis, a lethal granulomatous disease of the skin, muscle, and various inner tissues affecting various teleost and shellfish. Four species of Nocardia have been isolated from diseased fish and shellfish, namely Nocardia asteroides, Nocardia seriolae, Nocardia salmonicida and Nocardia crassostreae. Read More

    Pulmonary nocardiosis in a patient with idiopathic CD4 T-lymphocytopenia.
    Respirol Case Rep 2018 Feb 21;6(2):e00283. Epub 2017 Dec 21.
    Department of PulmonologyOakland University William Beaumont HospitalRoyal OakMichiganUSA.
    Idiopathic CD4 T-lymphocytopenia (ICL) is a rare immunodeficiency characterized by low CD4 T-lymphocyte count, which usually manifests with opportunistic infections. Nocardia as an opportunistic pathogen infecting patients with this condition has rarely been reported. Here, we describe the case of a 46-year-old male who presented with lung mass and respiratory and systemic symptoms and was eventually diagnosed with pulmonary nocardiosis. Read More

    Ventilator-dependent pulmonary nocardiosis in a patient with chronic obstructive pulmonary disease.
    Lung India 2018 Jan-Feb;35(1):58-61
    Department of Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA.
    Nocardiosis is a rare infectious disease entity that mostly affects the lungs, brain, or skin of immunocompromised individuals. Recent reports of pulmonary nocardiosis (PN) in patients with chronic obstructive pulmonary disease (COPD) as the only risk factor suggest a possible association between nocardiosis and COPD. Herein, we present a case of ventilator-dependent PN in a patient with a moderate degree of COPD. Read More

    Skin Infections due to Bacteria in Solid Organ Transplant Recipients: A Review.
    Dermatology 2018 Jan 10. Epub 2018 Jan 10.
    Department of Dermatology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
    Though there is an abundance of information on cutaneous malignancies in transplant recipients, cutaneous infections in solid organ transplant recipients (SOTRs) are underrepresented in the dermatological literature. Our paper provides a comprehensive review of bacterial cutaneous infections within the solid organ transplant population. Cutaneous bacterial infections may lead to significant morbidity and even mortality in this immunosuppressed population. Read More

    Chronic Nocardia cyriacigeorgica Periprosthetic Knee Infection Successfully Treated with a Two-Stage Revision: A Case Report.
    JBJS Case Connect 2017 Oct-Dec;7(4):e74
    Department of Orthopaedic Surgery (M.M.H., J.R.M., I.J.D., and J.A.B.) and Division of Infectious Disease and International Health, Department of Medicine (C.C.M.), University of Virginia, Charlottesville, Virginia.
    Case: We report the successful treatment of a Nocardia cyriacigeorgica periprosthetic joint infection (PJI) that occurred at the site of a total knee arthroplasty. To our knowledge, this organism has not previously been reported in the literature as a cause of PJI. Given the need for a prolonged duration of treatment for this organism (a minimum of 6 to 12 months), modifications to the standard 2-stage revision were made in consultation with infectious-disease specialists. Read More

    Diffuse Nocardial Spinal Subdural Empyema: Diagnostic Dilemma and Treatment Options.
    Cureus 2017 Oct 24;9(10):e1795. Epub 2017 Oct 24.
    Department of Neurosurgery, University of Louisville School of Medicine.
    Nocardiosis of the central nervous system and spine, in particular, is a rare infection with significant morbidity and mortality. Treatment is usually with antibiotics and surgical drainage or biopsy. The authors report a case of a 49-year-old man who presented with chronic lower back pain and paraplegia. Read More

    CT findings of pulmonary nocardiosis: a report of 9 cases.
    J Thorac Dis 2017 Nov;9(11):4785-4790
    Department of Respiratory and Critical Medicine, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen 518020, China.
    Background: Pulmonary nocardiosis often occurs among immunocompromised patients, especially in those with impaired cell immunity related to AIDS and transplant. As the number of patients receiving transplant, the occurrence of pulmonary nocardiosis may also increase. Radiologic characteristics of this entity have not been well documented. Read More

    Disseminated Nocardiosis Associated with Treatment with Infliximab in a Patient with Ulcerative Colitis.
    Am J Case Rep 2017 Dec 21;18:1365-1369. Epub 2017 Dec 21.
    Department of Internal Medicine, Texas Tech University Health Sciences Center at The Permian Basin, Odessa, TX, USA.
    BACKGROUND Opportunistic infections may occur when patients with inflammatory bowel disease (IBD) are treated with tumor necrosis factor (TNF)-alpha inhibitors. With the increasing use of new immunosuppressant drugs, the incidence of opportunistic or atypical infections is also increasing, including with Nocardia spp. A high level of awareness of atypical infections is warranted in immunosuppressed patients. Read More

    Case 249: Intramuscular Mycetoma.
    Radiology 2018 Jan;286(1):353-359
    From the Departments of Radiodiagnosis (Z.N., N.M.), Plastic Surgery (A.B.), and Microbiology (R.S.K.M.), Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow, Uttar Pradesh, India 226014.
    History A 21-year-old man presented with swelling of the medial aspect of the left thigh of 1-month duration. There was no history of fever or penetrating injury in the left thigh. The patient had undergone renal transplantation 7 years earlier and had been taking immunosuppressants since transplantation. Read More

    An overview of resistance profiles ESKAPE pathogens from 2010-2015 in a tertiary respiratory center in Romania.
    Rom J Morphol Embryol 2017 ;58(3):909-922
    "Marius Nasta" Institute for Pulmonary Medicine, Bucharest, Romania;
    Lower respiratory tract infections (LRTIs) is an umbrella term that covers a wide spectrum of diseases, comprising mild and severe, acute and chronic conditions. A wide spectrum of pathogens can be implicated, from viruses to pyogenic and atypical bacteria. A special place should be reserved for slow growing bacteria (Mycobacteria spp. Read More

    A case of empyema and septic arthritis due to.
    Clin Case Rep 2017 Dec 24;5(12):1976-1979. Epub 2017 Oct 24.
    Department of Respiratory MedicineSaitama Cardiovascular and Respiratory CenterSaitamaJapan.
    Septic arthritis due tosp. should be suspected when a patient with risk factors such as pneumoconiosis or diabetes mellitus develops joint symptoms, especially if the patient has had nocardiosis in other sites. Read More

    Syndrome of Inappropriate Antidiuretic Hormone Secretion Complicating Systemic Nocardiosis in a Renal Transplant Recipient: A Case Report.
    Transplant Proc 2017 Dec;49(10):2368-2371
    Nephrology Department and Renal Transplantation Unit, Laiko Hospital, National and Kapodistrian University of Athens, Greece.
    Background: Infection by Nocardia species is an uncommon cause of severe clinical syndromes, particularly in immunocompromised patients, and solid-organ transplantation is the most common underlying condition. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) has been described thus far in lung and stem cell transplants with systemic nocardiosis.

    Case Report: We report the first case of SIADH in a female elderly renal transplant recipient diagnosed with systemic nocardiosis 2 years after transplantation. Read More

    Dermatological Complications After Solid Organ Transplantation.
    Clin Rev Allergy Immunol 2018 Feb;54(1):185-212
    Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
    Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e. Read More

    In vitro activity of some essential oils alone and in combination against the fish pathogen Nocardia seriolae.
    Pol J Vet Sci 2017 Sep;20(3):559-566
    889-2192.
    Microplate resazurin assay was applied to investigate the in vitro activity of four essential oils (EOs); cinnamon (Cinnamomum zeylanicum), thyme (Thymus vulgaris), lemongrass (Cymbopogon flexuosus) and tea tree (Melaleuca alternifolia) oils against 80 clinical isolates of the fish pathogen Nocardia seriolae. The checkerboard test was then used to determine the possible synergistic effect of EOs combination against reference type strains of fish nocardiosis. All tested EOs had antibacterial activity against N. Read More

    Disseminated nocardiosis complicated by multiple brain abscesses and pleural empyema in a young diabetic man: a case report.
    Pathologica 2017 Sep;109(3):140-142
    Unit of Thoracic Surgery, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
    Nocardiosis is a life-threatening infection usually affecting immunocompromised patients. Very rarely it presented with intracranial abscesses and pleuro-parenchymal infections. We herein report a very challenging case of a 34-year-old obese and diabetic man affected by disseminated nocardiosis with multiple brain abscesses and pleural empyema. Read More

    Nocardiosis from 1888 to 2017.
    Microb Pathog 2018 Jan 13;114:369-384. Epub 2017 Nov 13.
    Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:
    The genus Nocardia is an aerobic bacterium, Gram-positive and catalase positive that is in Nocardiaceae family. This bacterium first described by Edmond Nocard in 1888 and is not in human commensal bacteria. To date, nocardiosis incidence is increasing due to increase population growth rate, increase in patients with immune disorder diseases and immunocompromised patients. Read More

    The Complexities of Nocardia Taxonomy and Identification.
    J Clin Microbiol 2018 Jan 26;56(1). Epub 2017 Dec 26.
    Microbiology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
    species are a complex group of organisms considered to belong to the aerobic actinomycetes. Of the validly described species, many have been implicated as the cause of serious human infections, especially in immunocompromised patients. The genus has a complicated taxonomic history; this is especially true for, the type species of the genus and previously the most frequently reported nocardial taxon from human specimens. Read More

    Successful Treatment of Disseminated Nocardiosis Caused by Nocardia veterana in a Dog.
    J Vet Intern Med 2018 Jan 4;32(1):418-422. Epub 2017 Nov 4.
    Department of Medicine & Epidemiology, University of California-Davis, Davis, CA.
    A 5-year-old male castrated Lhasa Apso cross was evaluated for a 1-month history of inappetence, lethargy, gagging, and progressive right thoracic limb lameness. Synovial fluid analysis revealed nonseptic suppurative inflammation, and a diagnosis of immune-mediated polyarthritis (IMPA) was made. After 3 months of treatment with prednisone and later cyclosporine, the dog developed multiple firm cutaneous and subcutaneous masses and a focal mass within the jejunum. Read More

    Transparent Tiger barb Puntius tetrazona, a fish model for in vivo analysis of nocardial infection.
    Vet Microbiol 2017 Nov 5;211:67-73. Epub 2017 Oct 5.
    Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fishery Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, Guangdong, 510380, China. Electronic address:
    Nocardiosis afflicts multiple species of cultured fish, resulting in substantial economic losses to the aquaculture industry, however, lack of detailed knowledge on disease pathogenesis has hampered the development of effective prevention and control strategies. In this study, we injected a green fluorescent protein (GFP)-labeled Nocardia seriolae strain into a transparent mutant strain of Tiger barb (Puntius tetrazona) to monitor tissue pathogen accumulation and tissue damage in vivo, and to clarify the relationship between pathogenic processes and overt symptoms. GFP-labeled bacteria were phagocytized by leukocytes and could proliferate within these cells, which in turn led to leukocyte aggregation, leukocyte death, and granuloma formation. Read More

    Granulomatous Thyroiditis: A Case Report and Literature Review.
    Ann Clin Lab Sci 2017 Sep;47(5):620-624
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
    Background: Granulomatous disease in the thyroid gland has been linked to viral, bacterial and autoimmune etiologies. The most common granulomatous disease of the thyroid is subacute granulomatous thyroiditis, which is presumed to have a viral or post-viral inflammatory cause. Bacterial etiologies include tuberculosis, actinomycosis, and nocardiosis, but are extremely rare. Read More

    Nocardia beijingensis pericarditis presenting with cardiac tamponade: A case report.
    Int J STD AIDS 2017 Jan 1:956462417736986. Epub 2017 Jan 1.
    1 Internal Medicine Department, Faculty of Medicine, 26682 Chiang Mai University , Chiang Mai, Thailand.
    We report the first case of Nocardia beijingensis pericarditis in a 32-year-old HIV-infected patient. He presented with cardiac tamponade after failing to respond to treatment for smear-negative pulmonary and pericardial tuberculosis (TB). The pericardial fluid was examined several times before it eventually revealed filamentous branching organisms in Gram and modified acid-fast bacilli stain. Read More

    Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
    Immunity 2017 Oct;47(4):710-722.e6
    Institute of Immunology and Infection Research, University of Edinburgh, EH9 3FL Edinburgh, UK. Electronic address:
    Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resistance in a T cell receptor (TCR)-independent manner. Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR. This shared signaling complex allowed IL-33 to induce the EGFR-mediated activation of the MAP-kinase signaling pathway and consequently the expression of IL-13. Read More

    Virulence test using nematodes to prescreenspecies capable of inducing neurodegeneration and behavioral disorders.
    PeerJ 2017 10;5:e3823. Epub 2017 Oct 10.
    UMR CNRS5557, INRA1418 Ecologie Microbienne, Université Lyon 1, VetAgro Sup, Université Claude Bernard (Lyon I), Lyon, France.
    Background: Parkinson's disease (PD) is a disorder characterized by dopaminergic neuron programmed cell death. The etiology of PD remains uncertain-some cases are due to selected genes associated with familial heredity, others are due to environmental exposure to toxic components, but over 90% of cases have a sporadic origin.are Actinobacteria that can cause human diseases like nocardiosis. Read More

    Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis.
    Case Rep Dermatol 2017 May-Aug;9(2):119-129. Epub 2017 Aug 17.
    Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially byIt appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis. Read More

    Mycobacterium grossiae sp. nov., a rapidly growing, scotochromogenic species isolated from human clinical respiratory and blood culture specimens.
    Int J Syst Evol Microbiol 2017 Nov 6;67(11):4345-4351. Epub 2017 Oct 6.
    1​Department of Laboratory Medicine, Yale School of Medicine/Yale-New Haven Hospital, New Haven, CT, USA.
    A previously undescribed, rapidly growing, scotochromogenic species of the genus Mycobacterium (represented by strains PB739and GK) was isolated from two clinical sources - the sputum of a 76-year-old patient with severe chronic obstructive pulmonary disease, history of tuberculosis exposure and Mycobacterium avium complex isolated years prior; and the blood of a 15-year-old male with B-cell acute lymphoblastic leukaemia status post bone marrow transplant. The isolates grew as dark orange colonies at 25-37 °C after 5 days, sharing features in common with other closely related species. Analysis of the complete 16S rRNA gene sequence (1492 bp) of strain PB739demonstrated that the isolate shared 98. Read More

    Unfolding of a Clinically Suspected Case of Pulmonary Tuberculosis.
    J Clin Diagn Res 2017 Aug 1;11(8):DD01-DD03. Epub 2017 Aug 1.
    Senior Consultant Microbiologist, Nirmal Laboratories, Puducherry, India.
    Pulmonary nocardiosis caused by Nocardia mimics pulmonary tuberculosis in many aspects. Here, we report a case of suspected pulmonary tuberculosis turning into pulmonary nocardiosis following microbiological evaluation. Sputum sample of the patient grew Nocardia otitidiscaviarum. Read More

    Clinical manifestations of nocardiosis: Study of risk factors and outcomes in a tertiary care hospital.
    J Lab Physicians 2017 Oct-Dec;9(4):288-295
    Department of Microbiology, Medanta-The Medicity, Sector-38, Gurgaon, Haryana, India.
    Purpose: The aim of this study is to evaluate the predisposing risk factors, clinical presentations, laboratory parameters, and treatments taken and outcomes in patients of nocardiosis in the span of 5 years in a tertiary care hospital.

    Materials And Methods: The patients whose specimens showedlike organism in Gram-staining, Kinyoun staining and characteristic colonies in culture were included in the retrospective analysis study. Retrospective analysis of associated risk factors, clinical presentations, and radiological findings was performed. Read More

    The value of molecular techniques to diagnose Ureaplasma urealyticum and Nocardia farcinica pleuropneumonia in a patient with diffuse large B-cell lymphoma.
    Int J Infect Dis 2017 Nov 22;64:93-95. Epub 2017 Sep 22.
    Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Centre-Cochin, Fédération d'Infectiologie, Paris, France; INSERM 1181 Biostatistics, Biomathematics, Pharmacoepidemiology, and Infectious Diseases (B2PHI), Paris, France.
    An unusual case of pleural empyema related to Nocardia farcinica and Ureaplasma urealyticum, occurring after autologous haematopoietic stem cell transplantation in a 30-year-old patient with lymphoma, is reported. This case illustrates the role of repeated and comprehensive microbiological investigations and the contribution of molecular techniques in reaching the aetiological diagnosis. Read More

    Update on the Management of Infectious Keratitis.
    Ophthalmology 2017 Nov 21;124(11):1678-1689. Epub 2017 Sep 21.
    Francis I. Proctor Foundation, University of California, San Francisco, California; Department of Ophthalmology, University of California, San Francisco, California. Electronic address:
    Infectious keratitis is a major global cause of visual impairment and blindness, often affecting marginalized populations. Proper diagnosis of the causative organism is critical, and although culture remains the prevailing diagnostic tool, newer techniques such as in vivo confocal microscopy are helpful for diagnosing fungus and Acanthamoeba. Next-generation sequencing holds the potential for early and accurate diagnosis even for organisms that are difficult to culture by conventional methods. Read More

    SUBTENON AMIKACIN INJECTION FOR THE TREATMENT OF NOCARDIA ASTEROIDES ORBITAL CELLULITIS IN A PATIENT WITH A HISTORY OF SCLERAL BUCKLING.
    Retin Cases Brief Rep 2017 Fall;11(4):332-334
    *Department of Ophthalmology, Dicle University of Medicine, Diyarbakir, Turkey; and†Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.
    Purpose: To evaluate the use of subtenon amikacin injection for the treatment of Nocardia asteroides orbital cellulitis in a patient with a history of scleral buckle surgery.

    Methods: Case report.

    Results: A 79-year-old diabetic woman presented with an 8-month history of diplopia, discharge, and swelling around her left eye. Read More

    Second report of ainfection in the United States: nodular scleritis with in vitro imipenem resistance.
    Digit J Ophthalmol 2016 10;22(3):62-66. Epub 2016 Aug 10.
    Department of Ophthalmology, University of Florida, Gainesville.
    We describe the case of a 52-year-old woman with scleritis caused by an imipenem-resistant strain of. The patient presented with pain, redness, and nodules on the sclera of 8 weeks' duration. A Gram stain from a nodule on the superonasal aspect of the globe was initially negative. Read More

    Susceptibility Testing of Tedizolid against Isolates of Nocardia.
    Antimicrob Agents Chemother 2017 Dec 22;61(12). Epub 2017 Nov 22.
    The University of Texas Health Science Center at Tyler, Department of Microbiology, Tyler, Texas, USA.
    There is a paucity of efficacious antimicrobials (especially oral) against clinically relevant species ofTo date, all species ofhave been susceptible to linezolid, the first commercially available oxazolidinone. Tedizolid is a new oxazolidinone with previously reported improvedand(intracellular) potency against multidrug-resistant strains ofsp. andUsing the current Clinical and Laboratory Standards Institute-recommended broth microdilution method, 101 isolates ofspp. Read More

    Nocardia infections in solid organ and hematopoietic stem cell transplant recipients.
    Curr Opin Infect Dis 2017 Dec;30(6):545-551
    aDepartment of Infectious Diseases, CUB-Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium bUnité Mobile de Microbiologie Clinique, Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou cUniversité Paris Descartes dCentre d'Infectiologie Necker-Pasteur, Institut Imagine, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
    Purpose Of Review: Nocardia spp. is a gram-positive bacteria that may cause infections in humans. Nocardiosis has been described since the early years of transplantation. Read More

    [Pulmonary nocardiosis with cerebral abscesses mimicking metastatic lung cancer: Three cases and a review of literature].
    Rev Mal Respir 2017 Nov 15;34(9):1016-1021. Epub 2017 Sep 15.
    Service de pneumologie, hôpital Pontchaillou, 35033 Rennes, France; Université de Rennes 1, 35000 Rennes, France.
    Nocardiosis is an infectious disease with wide range of clinical features, which can eventually lead to death. The agent responsible belongs to the genus Nocardia that includes about fifty different species. Nocardiosis occurs mainly in immunocompromised hosts. Read More

    Subcellular localization and function study of a secreted phospholipase C from Nocardia seriolae.
    FEMS Microbiol Lett 2017 Sep;364(17)
    College of Fisheries, Guangdong Ocean University, Zhanjiang 524088, PR China.
    Fish nocardiosis is a chronic systemic granulomatous disease, and Nocardia seriolae is the main pathogen that causes it. The pathogenesis and virulence factors of N. seriolae are not fully understood. Read More

    [Pulmonary nocardiosis in immunocompetent patients: about 2 cases].
    Pan Afr Med J 2017 29;27:149. Epub 2017 Jun 29.
    Service de Pneumo-Phtisiologie, Hôpital Moulay Youssef, Rabat, Maroc.
    Nocardiosis is a rare but severe infection caused by bacteria of the genus nocardia, which belong to the order actinomycetales. If they can affect immunocompetent adult, nocardioses are pathologies affecting the individuals with weakened immune system. Pulmonary involvement is the most common manifestation, its correct management is based on diagnosis, which is often delayed due to non-specific symptoms and inconclusive specimens. Read More

    The cytopathology of Actinomyces, Nocardia, and their mimickers.
    Diagn Cytopathol 2017 Dec 9;45(12):1105-1115. Epub 2017 Sep 9.
    Department of Pathology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio, 44106.
    Nocardia species and Actinomyces species are 2 of the most commonly diagnosed filamentous bacteria in routine cytopathology practice. These genera share many overlapping cytomorphologic features, including their thin, beaded, branching, Gram-positive, GMS-positive filamentous structures that fragment at their peripheries into bacillary- and coccoid-appearing forms. Features that help distinguish between these 2 microorganisms include the width of their filamentous structures, the angles at which they branch, and their ability or lack thereof to retain a modified acid-fast stain. Read More

    Identification and antimicrobial susceptibility of clinical Nocardia species in a tertiary hospital in China.
    J Glob Antimicrob Resist 2017 Dec 1;11:183-187. Epub 2017 Sep 1.
    Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address:
    Objectives: There is a lack of information on the activities of antimicrobial agents against Nocardia clinical isolates of specific species in China. The aim of this study was to determine the antibiotic susceptibility of 28 clinical isolates of Nocardia spp. isolated from Beijing Chao-Yang Hospital (Beijing, China). Read More

    Non-Coding RNAs are Differentially Expressed byand in Experimental Actinomycetoma.
    Open Microbiol J 2017 30;11:112-125. Epub 2017 Jun 30.
    Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México.
    Introduction: spp. are common soil-inhabiting bacteria that frequently infect humans through traumatic injuries or inhalation routes and cause infections, such as actinomycetoma and nocardiosis, respectively.is the main aetiological agent of actinomycetoma in various countries. Read More

    Mycetoma laboratory diagnosis: Review article.
    PLoS Negl Trop Dis 2017 Aug 24;11(8):e0005638. Epub 2017 Aug 24.
    The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.
    Mycetoma is a unique neglected tropical disease caused by a substantial number of microorganisms of fungal or bacterial origins. Identification of the causative organism and the disease extension are the first steps in the management of the affected patients and predicting disease treatment outcome and prognosis. Different laboratory-based diagnostic tools and techniques were developed over the years to determine and identify the causative agents. Read More

    A Novel Case of Pulmonary Nocardiosis with Secondary Hemophagocytic Lymphohistiocytosis.
    Chin Med J (Engl) 2017 Sep;130(17):2128-2129
    Center for Respiratory Diseases, China-Japan Friendship Hospital; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Clinical Research Center for Respiratory Diseases, Beijing 100029, China.

    Therapeutic Femtosecond Laser-Assisted Lamellar Keratectomy for Multidrug-Resistant Nocardia Keratitis.
    Cornea 2017 Nov;36(11):1429-1431
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL.
    Purpose: To describe the novel use of femtosecond laser technology for therapeutic resection of infectious foci in a case of multidrug-resistant Nocardia asteroides keratitis.

    Methods: A 30-year-old man presented with a corneal infiltrate. Cultures were taken, and fortified vancomycin and tobramycin were initiated. Read More

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