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    1 OF 110

    Pulmonary Nocardiosis: A Clinical Analysis of 30 Cases.
    Intern Med 2017 15;56(12):1485-1490. Epub 2017 Jun 15.
    Department of Laboratory Medicine, Chiba Aoba Municipal Hospital, Japan.
    Objective Pulmonary nocardiosis frequently develops as an opportunistic infection in patients with malignant tumor and is treated with steroids. This study was performed to clarify the clinical features of pulmonary nocardiosis in Japan. Methods The patients definitively diagnosed with pulmonary nocardiosis at our hospital between January 1995 and December 2015 were retrospectively investigated. Read More

    Imaging Spectrum of Invasive Fungal and Fungal-like Infections.
    Radiographics 2017 Jun 16:160110. Epub 2017 Jun 16.
    From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Box 8131, St Louis, MO 63110 (H.L.P.O., S.M., V.M.M., S.B.); Department of Radiology, University of Wisconsin, Madison, Wis (M.G.L., P.J.P.); and Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.).
    Invasive fungal and fungal-like infections contribute to substantial morbidity and mortality in immunocompromised individuals. The incidence of these infections is increasing-largely because of rising numbers of immunocompromised patients, including those with neutropenia, human immunodeficiency virus, chronic immunosuppression, indwelling prostheses, burns, and diabetes mellitus, and those taking broad-spectrum antibiotics. Invasive fungal pathogens include primary mycotic organisms such as Histoplasma capsulatum, Coccidioides immitis, Blastomyces dermatitidis, and Paracoccidioides brasiliensis, which are true pathogens and inherently virulent. Read More

    Pulmonary and cutaneous infection caused by Nocardia farcinica in a patient with nephrotic syndrome: A case report.
    Medicine (Baltimore) 2017 Jun;96(24):e7211
    aDepartment of Cardiology bDepartment of Nephrology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, Zhejiang Province, PR China.
    Rationale: Nocardia species is known as conditional pathogenic bacteria. Disseminated infection caused by Nocardia species is rare and occurs primarily in immunosuppressed patients. Signs and symptoms of this infection are frequently nonspecific making early diagnosis and treatment difficult. Read More

    [Brain abscesses caused by Nocardia farcinica in a kidney transplanted man].
    Ugeskr Laeger 2017 Jun;179(23)
    Nocardiosis is primarily an opportunistic infection caused by aerobic Gram-positive bacteria of the genus Nocardia. In this case report we describe a male patient who previously received a kidney transplant and was admitted to hospital with chills, headache and pain in the neck and left eye, tremor and coordination problems. A magnetic resonance scan of the brain showed multiple abscesses, and blood culture was positive for Nocardia farcinica. Read More

    Adjuvant effect of recombinant interleukin-12 in the Nocardiosis formalin-killed vaccine of the amberjack Seriola dumerili.
    Fish Shellfish Immunol 2017 Jun 7;67:263-269. Epub 2017 Jun 7.
    The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890-8580, Japan; Faculty of Fisheries, Kagoshima University, Kagoshima 890-0056, Japan. Electronic address:
    Nocardiosis causes serious economic damage in the fish farming of Japanese yellowtail fish. Nocardia seriolae identified as pathogenic bacterium is an intracellular-pathogen. In general, induction of cell-mediated immunity (CMI) is effective in infection defense against intracellular-pathogen. Read More

    Respiratory infections associated with anti-TNFα agents.
    Med Mal Infect 2017 Jun 8. Epub 2017 Jun 8.
    Service des maladies respiratoires, hôpital Haut-Lévêque, CHU de Bordeaux, 1, avenue Magellan, 33604 Pessac cedex, France.
    Anti-TNFα agents have proved effective in the treatment of various inflammatory, rheumatologic, dermatologic, and gastrointestinal diseases. Severe respiratory tract infections of bacterial or fungal origin have emerged as important complications in patients receiving such treatments. The risk of infection due to anti-TNFα therapy is difficult to assess in these patients who are immunocompromised because of the underlying disease itself and of previous or concomitant immunosuppressive drugs. Read More

    Isolation, biochemical and molecular identification of Nocardia species among TB suspects in northeastern, Tanzania; a forgotten or neglected threat?
    BMC Infect Dis 2017 Jun 8;17(1):407. Epub 2017 Jun 8.
    Department of Medical Microbiology and Epidemiology of Infectious Diseases, Faculty of Medicine, University of Leipzig, Liebig Str. 21, 04103, Leipzig, Germany.
    Background: Pulmonary nocardiosis mimic pulmonary tuberculosis in most clinical and radiological manifestations. In Tanzania, where tuberculosis is one of the major public health threat clinical impact of nocardiosis as the cause of the human disease remains unknown. The objective of the present study was to isolate and identify Nocardia isolates recovered from TB suspects in Northeastern, Tanzania by using biochemical and molecular methods. Read More

    Nocardia infection following intraocular surgery: Report of seven cases from a tertiary eye hospital.
    Indian J Ophthalmol 2017 May;65(5):371-375
    Department of Cornea and Anterior Segment, Dr. Shroff's Charity Eye Hospital, New Delhi, India.
    Purpose: To study the outcome of ocular nocardiosis following intraocular surgery.

    Materials And Methods: A retrospective review of medical records of all postoperative cases of culture proven Nocardia infection over a period of 3 years, from October 2010 to September 2013, was performed. Microbiological analysis was performed for all cases and included smears and cultures. Read More

    Practical Management of Deep Cutaneous Fungal Infections.
    Med Mycol J 2017 ;58(2):E71-E77
    Department of Dermatology, Kitasato University Kitasato Institute Hospital.
    Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining. Read More

    Cutaneous nocardiosis manifesting as a frontal mass in a patient with giant cell arteritis.
    Clujul Med 2017 25;90(2):231-234. Epub 2017 Apr 25.
    Rheumatology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
    We report the case of a subcutaneous abscess due to Nocardia spp. mimicking a spontaneous hematoma or an aneurysm of the temporal artery branch, in a giant cell arteritis patient treated with methylprednisolone and azathioprine. Ultrasonography, incision and drainage with cultures helped in the diagnosis. Read More

    Approach to skin and soft tissue infections in non-HIV immunocompromised hosts.
    Curr Opin Infect Dis 2017 May 24. Epub 2017 May 24.
    Section of Infectious Diseases and HIV Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
    Purpose Of Review: Skin and soft tissue infections are frequent contributors to morbidity and mortality in the immunocompromised host. This article reviews the changing epidemiology and clinical manifestations of the most common cutaneous pathogens in non-HIV immunocompromised hosts, including patients with solid organ transplants, stem cell transplants, solid tumors, hematologic malignancies, and receiving chronic immunosuppressive therapy for inflammatory disorders.

    Recent Findings: Defects in the innate or adaptive immune response can predispose the immunocompromised host to certain cutaneous infections in a predictive fashion. Read More

    Disseminated Nocardia Farcinica Pneumonia with Left Adrenal Gland Abscess.
    Cureus 2017 Apr 12;9(4):e1160. Epub 2017 Apr 12.
    Internal Medicine, University of Tennessee Health Science Center Memphis.
    Adrenal masses pose a diagnostic challenge. The differential diagnosis includes functional adrenal tumors, incidentally found adrenal masses, metastases from an unknown primary cancer, and abscesses. Infrequently, adrenal gland abscesses have been reported in disseminated nocardiosis affecting immunocompetent and immunocompromised patients. Read More

    Disseminated cutaneous nocardiosis with ocular involvement.
    J Eur Acad Dermatol Venereol 2017 May 13. Epub 2017 May 13.
    Department of Dermatology, National Defense Medical College, Tokorozawa, Japan.
    A 45-year-old Japanese woman presented with a five-day history of multiple papular eruptions and a fever >38°C. For the past 10 years, she had been treated with oral prednisolone (10 mg/day) and cyclosporine (100 mg/day) to treat mixed connective tissue disease and autoimmune hepatitis. On physical examination, multiple papules and pustules were observed on her face, trunk, and extremities. Read More

    Infections in Hematopoietic Cell Transplant Recipients: Results From the Organ Transplant Infection Project, a Multicenter, Prospective, Cohort Study.
    Open Forum Infect Dis 2017 22;4(2):ofx050. Epub 2017 Mar 22.
    University of Alabama at Birmingham.
    Background: Infection is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Our object was to better define the epidemiology and outcomes of infections after HCT.

    Methods: This was a prospective, multicenter cohort study of HCT recipients and conducted from 2006 to 2011. Read More

    Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids.
    Infect Immun 2017 Jul 20;85(7). Epub 2017 Jun 20.
    Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
    Nontoxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans cause invasive disease in humans and animals. Host sensing of corynebacteria is largely uncharacterized, albeit the recognition of lipoglycans by Toll-like receptor 2 (TLR2) appears to be important for macrophage activation by corynebacteria. The members of the order Corynebacterineae (e. Read More

    Culture-Proven Thorn-Associated Infections in Arizona: 10-Year Experience at Mayo Clinic.
    Open Forum Infect Dis 2017 10;4(1):ofx017. Epub 2017 Feb 10.
    Division of Infectious Diseases.
    Background: Thorn injuries are common in the desert Southwest; however, the frequency and microbiology of thorn-associated infections have not been systematically described. Most information comes from case reports describing infections from atypical or environmental microorganisms. Our aim was to summarize the spectrum of thorn-associated infections. Read More

    Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature.
    Ann Clin Microbiol Antimicrob 2017 Apr 14;16(1):31. Epub 2017 Apr 14.
    MTA-SZTE "Lendület" Fungal Pathogenicity Mechanisms Research Group, Hungarian Academy of Sciences, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary.
    Background: Scedosporium apiospermum is an emerging opportunistic filamentous fungus, which is notorious for its high levels of antifungal-resistance. It is able to cause localized cutaneous or subcutaneous infections in both immunocompromised and immunocompetent persons, pulmonary infections in patients with predisposing pulmonary diseases and invasive mycoses in immunocompromised patients. Subcutaneous infections caused by this fungus frequently show chronic mycetomatous manifestation. Read More

    Detection of high serum levels of β-D-Glucan in disseminated nocardial infection: a case report.
    BMC Infect Dis 2017 Apr 13;17(1):272. Epub 2017 Apr 13.
    Second Department of Internal Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto-machi, Nagasaki, Japan.
    Background: β-D-glucan (BDG) is a helpful diagnostic marker for many invasive fungal infections, but not for nocardiosis. Here, we reported the first case of nocardial infection with high serum level of BDG.

    Case Presentation: A 73-year-old man was hospitalized because of fever, headache, and appetite loss after 10 months of steroid and immunosuppressive therapy for cryptogenic organizing pneumonia. Read More

    Primary cutaneous nocardiosis caused by Nocardia brasiliensis following a wasp sting.
    Clin Exp Dermatol 2017 Apr 10. Epub 2017 Apr 10.
    Department of Dermatology, West China Hospital, Sichuan University No. 37 of Guo Xue Xiang, Chengdu, Sichuan, China.
    We report a case of an 87-year-old woman who presented with painful erythema of her right forearm 10 days after she had been stung by a wasp on her right hand. The lesion had rapidly deteriorated during the week before presentation, and treatment with antibiotics and glucocorticoids did not improve the condition. After careful evaluation, we performed cultures from the lesion aspiration, and morphological and genetic analysis of bacteria cultures confirmed a bacterial infection with Nocardia brasiliensis. Read More

    Surgery of a nocardia lung abscess presenting as a tension pyopneumothorax.
    Asian Cardiovasc Thorac Ann 2017 May 7;25(4):315-317. Epub 2017 Apr 7.
    Department of Thoracic Surgery, Nishi-Kobe Medical Center, Hyogo, Japan.
    While some cases of nocardial pneumonia develop secondary empyema, tension pyopneumothorax is a very rare and lethal complication. A 74-year-old man who exhibited thrombocytopenia during steroid therapy for autoimmune hepatitis, presented to our department with a nocardial tension pyopneumothorax. He underwent a left lower lobectomy after chest drainage, and was discharged without any complication other than reoperation to remove a postoperative hematoma. Read More

    Meningitis and Ventriculitis due to Nocardia araoensis Infection.
    Intern Med 2017 1;56(7):853-859. Epub 2017 Apr 1.
    Division of Neurology, Minamata City Hospital, Japan.
    A 73-year-old man was admitted to our hospital with disturbance of consciousness, fever and headache. Cerebrospinal fluid (CSF) analysis revealed pleocytosis with neutrophil predominance, increased protein and low glucose. CSF and blood cultures yielded negative results. Read More

    Nocardiosis in freshwater reared Chinook salmon (Oncorhynchus tshawytscha).
    N Z Vet J 2017 Jul 26;65(4):214-218. Epub 2017 Apr 26.
    a Animal Health Laboratory , Ministry for Primary Industries , 66 Ward Street, Upper Hutt , New Zealand.
    Case History: An investigation was conducted to identify the cause of mortalities in freshwater reared Chinook salmon (Oncorhynchus tshawytscha). Mortalities occurred in juvenile salmon, at a salmon rearing facility in the South Island of New Zealand. The affected fish were from a pen inside the facility with no surrounding pens or other year classes affected. Read More

    Severe pneumonia due to Nocardia otitidiscaviarum identified by mass spectroscopy in a cotton farmer: A case report and literature review.
    Medicine (Baltimore) 2017 Mar;96(13):e6526
    aDepartment of Nephrology bDepartment of Respiratory and Critical Care Medicine cDepartment of Laboratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.
    Rationale: Nocardia species are aerobic saprophytic bacilli. Among Nocardia species, Nocardia otitidiscaviarum (N otitidiscaviarum) is rarely reported in pulmonary infection.

    Patient Concerns: We reported a case of N otitidiscaviarum pneumonia in a cotton farmer. Read More

    Successful treatment of pulmonary nocardiosis with fluoroquinolone in bronchial asthma and bronchiectasis.
    Respirol Case Rep 2017 May 26;5(3):e00229. Epub 2017 Mar 26.
    Division of Haematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.
    A 72-year-old Japanese woman was admitted at Saga University Hospital for fever, malaise, and productive cough. Six years ago, she had been diagnosed with bronchial asthma and was treated with inhaled corticosteroids. Chest radiograph and computed tomography on admission showed infiltrates in the right middle lobe, a mass lesion in the left lower lobe, and bronchiectasis in both lower lobes. Read More

    Nocardia brasiliensis Infection Complicating Cryptogenic Organizing Pneumonia.
    Case Rep Pulmonol 2017 28;2017:9567175. Epub 2017 Feb 28.
    Division of Pulmonary, Allergy and Sleep Medicine, Mayo Clinic, Jacksonville, FL, USA.
    Pulmonary nocardiosis is a severe and uncommon opportunistic infection caused by Nocardia species. We present a patient with cryptogenic organizing pneumonia who was receiving long-term immunosuppressive therapy, whose treatment course was complicated by cutaneous and pulmonary nocardiosis. Tissue cultures confirmed Nocardia brasiliensis. Read More

    First case report of pulmonary nocardiosis caused by Nocardia mexicana.
    JMM Case Rep 2016 Aug 30;3(4):e005054. Epub 2016 Aug 30.
    Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuoku, Chiba City, Chiba, 260-8673, Japan.
    Introduction: Nocardia species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, Nocardia species may sometimes cause an infection disease in immunocompetent hosts. Nocardia mexicana infections are the least common and are very rare. Read More

    Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses.
    Int J Infect Dis 2017 Jun 22;59:25-28. Epub 2017 Mar 22.
    Department of Internal Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the Netherlands. Electronic address:
    Despite advances in medical care, mortality due to cerebral Nocardia abscesses remains unacceptably high. The case of a typical immunocompromised patient, who deteriorated clinically despite optimal antimicrobial treatment, is reported here. Adjuvant immunotherapy with interferon-gamma resulted in partial restoration of the immune response and a corresponding clinical and radiographic recovery. Read More

    Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study.
    Clin Infect Dis 2017 May;64(10):1396-1405
    Division of Infectious Diseases, CUB-Erasme, Université Libre de Bruxelles, Belgium.
    Background: Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with 1-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days).

    Methods: We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014. Read More

    Endogenous Nocardial Endophthalmitis in an Immunosuppressed Patient: A Serious Warning of an Underlying Life Threatening and Blinding Disorder.
    J Ophthalmic Vis Res 2017 Jan-Mar;12(1):113-116
    Department of Ophthalmology, Army Hospital Research and Referral, Delhi Cantonment, India.
    Purpose: To report a case of bilateral endogenous nocardial endophthalmitis with central nervous system involvement in an immunocompromised individual with an extremely poor outcome.

    Case Report: A 35-year-old man with a history of long-term, prescribed oral steroid use for membranoproliferative glomerulonephritis presented with profound bilateral vision loss. Patient's diagnosis of bilateral endogenous nocardial endophthalmitis was delayed. Read More

    Pulmonary Nocardia beijingensis infection associated with the use of alemtuzumab in a patient with multiple sclerosis.
    Mult Scler 2017 May 1;23(6):872-874. Epub 2017 Feb 1.
    Department of Internal Medicine, UAB School of Medicine, Huntsville, AL, USA.
    Nocardia is a Gram-positive aerobic pathogen that usually affects immunocompromised patients. We report a case of pulmonary infection caused by a rare Nocardia species, Nocardia beijingensis, in a 50-year-old woman who had received alemtuzumab for the treatment of her multiple sclerosis. The invasive pulmonary infection was successfully treated with meropenem. Read More

    Cloning, Expression, Invasion, and Immunological Reactivity of a Mammalian Cell Entry Protein Encoded by the mce1 Operon of Nocardia farcinica.
    Front Microbiol 2017 22;8:281. Epub 2017 Feb 22.
    State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing, China.
    Bacterial mammalian cell entry (Mce) proteins have been implicated in pathogen invasion of mammalian host cells. The aim of this study was to examine the invasion-conferring ability of mce1E operon-encoded proteins, in vivo expression of Mce1E in cells from infected mice and rabbits, and Mce1E immunogenicity. Nocardia farcinica mce1E was cloned into pet30a(+) vectors, expressed in Escherichia coli, and purified. Read More

    Analysis of the complete genome sequence of Nocardia seriolae UTF1, the causative agent of fish nocardiosis: The first reference genome sequence of the fish pathogenic Nocardia species.
    PLoS One 2017 3;12(3):e0173198. Epub 2017 Mar 3.
    Research Center for Bioinformatics and Biosciences, National Research Institute of Fisheries Science, Japan Fisheries Research and Education Agency, Yokohama, Kanagawa, Japan.
    Nocardiosis caused by Nocardia seriolae is one of the major threats in the aquaculture of Seriola species (yellowtail; S. quinqueradiata, amberjack; S. dumerili and kingfish; S. Read More

    Susceptibility profiles of Nocardia spp. to antimicrobial and antituberculotic agents detected by a microplate Alamar Blue assay.
    Sci Rep 2017 Mar 2;7:43660. Epub 2017 Mar 2.
    State Key Laboratory for Infectious Disease Prevention and Control and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing 102206, China.
    Nocardia species are ubiquitous in natural environments and can cause nocardiosis. Trimethoprim-sulfamethoxazole has long been the monotherapy treatment of choice, but resistance to this treatment has recently emerged. In this study, we used microplate Alamar Blue assays to determine the antimicrobial susceptibility patterns of 65 standard Nocardia isolates, including 28 type strains and 20 clinical Nocardia isolates, to 32 antimicrobial agents, including 13 little studied drugs. Read More

    Increasing Nocardia Incidence Associated with Bronchiectasis at a Tertiary Care Center.
    Ann Am Thorac Soc 2017 Mar;14(3):347-354
    2 Division of Infectious Diseases and International Health, Department of Medicine.
    Rationale: Nocardia is a genus of pathogens that most commonly afflict immunocompromised hosts but may be an emerging infection among persons with bronchiectasis.

    Objectives: To examine the epidemiology and clinical presentation of adult patients with Nocardia and bronchiectasis relative to other patient groups.

    Methods: We examined a retrospectively assembled cohort of adults at Duke University Hospital in Durham, North Carolina with at least one positive culture from a bodily fluid or tissue specimen for Nocardia between January 1996 and December 2013. Read More

    Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil.
    PLoS Negl Trop Dis 2017 Feb 13;11(2):e0005301. Epub 2017 Feb 13.
    National Institute of Infectious Diseases, Oswaldo Cruz Foundation - Rio de Janeiro - Brazil.
    Mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. The purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil, between 1991 and 2014. Twenty-one cases of mycetoma were included in the study. Read More

    Myelosuppression-sparing treatment of central nervous system nocardiosis in a multiple myeloma patient utilizing a tedizolid-based regimen: a case report.
    Int J Antimicrob Agents 2017 Apr 8;49(4):488-492. Epub 2017 Feb 8.
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB 6153B, Cincinnati, OH 45267, USA. Electronic address:
    Central nervous system (CNS) nocardiosis is a recognised opportunistic infection in immunocompromised patients. Treatment involves prolonged institution of antibiotics, making oral agents a convenient and desired option. Unfortunately, devising an effective, well-tolerated antimicrobial for the duration required to treat CNS nocardiosis is challenging owing to treatment intolerance and toxicities. Read More

    [Pulmonary co-infection due to Nocardia cyriacigeorgica and Aspergillus fumigatus].
    Rev Esp Quimioter 2017 Apr 8;30(2):123-126. Epub 2017 Feb 8.
    Rocío Trastoy, Servicio de Microbiología y Parasitología. Complejo Hospitalario Universitario de Santiago de Compostela. Travesía de Choupana, s/n, 15706 Santiago de Compostela, A Coruña, Spain.
    Objective: Pulmonary nocardiosis is an uncommon pulmonary infection caused by aerobic gram-positive bacteria of the genus Nocardia. Nocardia sp. are environmental organisms spread worldwide. Read More

    Tuberculosis 'The Great Imitator': A usual disease with unusual presentations.
    Indian J Tuberc 2017 Jan 4;64(1):54-59. Epub 2016 Jul 4.
    Lecturer, Dept. of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
    Background: A number of infectious diseases have been referred to by the phrase 'The Great Imitator', of which the oldest is syphilis; others include Lyme disease, nocardiosis, etc. Tuberculosis has been described as the second great imitator as it can imitate various other disease processes. An awareness of the atypical clinical manifestations of tuberculosis is important, especially in regions where tuberculosis continues to be a major public health problem, such as India. Read More

    Disseminated Nocardiosis in renal transplant recipient under therapy for pulmonary tuberculosis: a case report.
    BMC Res Notes 2017 Feb 3;10(1):83. Epub 2017 Feb 3.
    Department of Microbiology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
    Background: Nocardiosis is an opportunistic infection in a patient with underlying immune suppression and organ transplant. Clinical syndromes are varied and ranges from pulmonary, disseminated, cutaneous along with central nervous system involvement.

    Case Presentation: Herein, we report a rare case of disseminated pulmonary nocardiosis with cerebral manifestation in a 66 year-old-Nepali farmer; with a history of renal transplantation and undergoing therapy for pulmonary tuberculosis. Read More

    Nocardia liver abscess post liver transplantation-A rare presentation.
    Transpl Infect Dis 2017 Apr 6;19(2). Epub 2017 Mar 6.
    Department of Liver Disease and Transplantation, Global Health City, Chennai, India.
    Nocardiosis is usually a disseminated disease seen in immunocompromised individuals. We herein present a rare case of isolated Nocardia liver abscess post liver transplantation. The patient responded well to treatment and is on long-term antibiotics for Nocardia infection. Read More

    A case of central nervous system nocardiosis in a patient with lupus treated with belimumab.
    Eur J Rheumatol 2016 Dec 1;3(4):188-190. Epub 2016 Dec 1.
    Department of Rheumatology, Medstar Washington Hospital Center, Washington, USA; Department of Clinical Medicine, Georgetown University Medical, Center, Washington, USA.
    Belimumab was approved by the United States Food and Drug Administration in March 2011 as the first biological agent for treating active systemic lupus erythematosus (SLE). To the best of our knowledge, this is the first case report regarding a patient with SLE treated with belimumab who was diagnosed with central nervous system nocardiosis. Read More

    First case of Nocardia amamiensis pulmonary infection in Mexico.
    New Microbes New Infect 2017 Mar 9;16:1-2. Epub 2016 Dec 9.
    Department of Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
    We report a case of Nocardia amamiensis pulmonary infection in a 43-year-old immunocompromised woman. The patient was treated with imipenem/cilastatin and trimethoprim/sulfamethoxazole and had a favourable outcome. It is important that laboratories perform species identification to understand the epidemiology and susceptibility patterns of the different Nocardia spp. Read More

    Pulmonary nocardiosis caused by Nocardia otitidiscaviarum in an adult asthmatic female patient: The presence of acid-fast branching filaments is always significant.
    S Afr Med J 2016 Dec 21;107(1):43-45. Epub 2016 Dec 21.
    Department of Preventive Medicine, Faculty of Veterinary Medicine, University of Khartoum, Sudan.
    We report a case of pulmonary nocardiosis in a 41-year-old asthma patient. Chest radiographs showed bilateral air space and consolidations.Acid-fast branching filaments were demonstrated in sputum, and the grown organism was identified phenotypically and confirmed using16S rDNA sequencing (accession no. Read More

    Systemic nocardiosis in a dog caused by Nocardia cyriacigeorgica.
    BMC Vet Res 2017 Jan 21;13(1):30. Epub 2017 Jan 21.
    Department of Pathology, School of Veterinary Medicine, Firat University, 23 200, Elazig, Turkey.
    Background: Systemic nocardiosis due to Nocardia cyriacigeorgica has not been reported in dogs.

    Case Presentation: Light and electron microscopy, microbiological culture and molecular identification (PCR) were used to diagnose systemic nocardiosis caused by Nocardia cyriacigeorgica in a 3-month-old husky dog. The postmortem changes included multifocal to coalescing, sharply circumscribed pyogranulomatous inflammation and abscess formation in lungs, liver, myocardium, spleen, kidneys, brain, and hilar lymph nodes. Read More

    Nocardiosis in ectopic ACTH syndrome: A case report and review of 11 cases from the literature.
    Exp Ther Med 2016 Dec 27;12(6):3626-3632. Epub 2016 Oct 27.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China; The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.
    Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) associated with nocardiosis is rare, and little information is available regarding its clinical characteristics. In this study, the case of a 35-year-old male patient who showed significant cushingoid features and had a cough with yellow phlegm for 1 month is described. Pulmonary computed tomography (CT) scanning and (18)F-fluorodeoxyglucose positron emission tomography combined with CT identified two different lesions in the mediastinum and pulmonary region, respectively. Read More

    Molecular analysis and species diversity of Nocardia in the hospital environment in a developing country, a potential health hazard.
    J Med Microbiol 2017 Mar 23;66(3):334-341. Epub 2017 Mar 23.
    2​Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Purpose: Despite hundreds of reports on the isolation of Nocardia from clinical samples, the presence and diversity of Nocardia species that are capable of survival in a harsh and adverse condition, such as a hospital environment, have not been comprehensively studied. The aim of this study was to assess Nocardia species diversity in a hospital environment to provide a better insight into their potential threat as a reservoir for the development of nosocomial infections.

    Methodology: A total of 90 samples of hospital water, dust and soil, collected from 30 hospitals, were analysed for the presence of Nocardia using standard protocols for isolation and characterization of the isolates. Read More

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