Search Our Scientific Publications & Authors

Proc Natl Acad Sci U S A 2020 Jun 18;117(22):11954-11960. Epub 2020 May 18.

Department of Atmospheric and Oceanic Sciences, University of California Los Angeles, CA 90095;

Assessment of the global budget of the greenhouse gas nitrous oxide ([Formula: see text]O) is limited by poor knowledge of the oceanic [Formula: see text]O flux to the atmosphere, of which the magnitude, spatial distribution, and temporal variability remain highly uncertain. Here, we reconstruct climatological [Formula: see text]O emissions from the ocean by training a supervised learning algorithm with over 158,000 [Formula: see text]O measurements from the surface ocean-the largest synthesis to date. The reconstruction captures observed latitudinal gradients and coastal hot spots of [Formula: see text]O flux and reveals a vigorous global seasonal cycle. Read More

Environ Sci Pollut Res Int 2020 Jun 10;27(17):21487-21496. Epub 2020 Apr 10.

Wetland Ecosystem Research Station of Hangzhou Bay, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou, 311400, Zhejiang, China.

Salinity has a significant impact on the sewage treatment efficiency of constructed wetlands (CWs), as well as affecting the greenhouse gas emissions of CWs. A lab-scale CW simulation system was constructed to observe the treatment efficiency and greenhouse gas flux occurring in CWs at different influent salinities (0%, 0.5%, 1. Read More

Environ Sci Pollut Res Int 2020 Jun 28;27(16):19783-19797. Epub 2020 Mar 28.

Faculty of Economics, TNU - University of Economics and Business Administration, Tan Thinh Ward, Thai Nguyen City, Thai Nguyen Province, Vietnam.

Identifying environmental consequences of international trade has a crucial role in constructing and planning strategies of any country, especially in developing countries that are currently witnessing a significant increase in trade openness; however, little efforts are made to investigate the environmental consequences of trade openness. The paper attempts to investigate the dynamic relationship between trade openness and environmental pollutants incorporating potential factors affecting environmental quality in 66 developing economies over the period 1971-2017. This article employs the powerful approach two-step generalized method of moment's estimators with a finite sample correction to obtain more accurate inference. Read More

Korean J Anesthesiol 2020 Mar 25. Epub 2020 Mar 25.

Department of Anaesthesia and OR Administration, King Fahd Medial City, Riyadh, Saudi Arabia.

Background: Some early reports on dexmedetomidine suggest that it impairs cerebral autoregulation and may have deleterious effects; however, concrete evidence is lacking. This study was perfomed to assess its effect on dynamic cerebral autoregulation (dCA) using transcranial Doppler (TCD).

Methods: Thirty American Society of Anesthesiologists physical status I and II patients between 18 and 60 years, undergoing lumbar spine surgery, received either an infusion of dexmedetomidine (Group D) or normal saline (Group C), followed by anesthesia induction with propofol, fentanyl and maintenance with oxygen, nitrous oxide and sevoflurane. Read More

Mol Genet Metab Rep 2020 Jun 17;23:100579. Epub 2020 Mar 17.

Reference Centre for Inborn Errors of Metabolism, Robert-Debré University Hospital, APHP, Paris 75019, France.

Nitrous oxide (NO) is widely used as an anesthetic or an analgesic. NO prolonged and recurrent administration is known to affect vitamin B12 metabolism with subsequent clinical consequences. We report herein the case of a 13-year-old girl with sickle cell disease exhibiting severe neurological and biochemical signs of functional vitamin B12 deficiency due to prolonged and repeated exposure to NO. Read More

Rev Chil Pediatr 2019 Dec;90(6):649-656

Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Madrid, España.

Introduction: We analyze the effectiveness and safety of a specific analgosedation protocol for procedures, and eva luate the satisfaction of the health personnel with each procedure.

Patients And Method: Prospective study of an analgosedation protocol for hospital procedures in children under 18 years of age, with an individualized strategy based on the patient's baseline situation, the type of procedure and the experience of the pediatrician responsible for the sedation. The following variables were recorded: diagnosis motivating the procedure, type of procedure, anthropometric data, allergies, medication, ASA status and baseline disease, fasting time, lung auscultation, temperature, oxygen saturation, res piratory rate, heart rate, blood pressure, sedation location, type of drug, dose, route of administra tion, Ramsay sedation scale, duration of sedation, type and treatment of adverse effects, presence of family members throughout the procedure, and patient satisfaction. Read More

Sci Total Environ 2020 Jun 29;721:137636. Epub 2020 Feb 29.

Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

Biochar application is considered an effective method of reducing nitrous oxide (NO) emissions in soil. However, the mechanism and temporal effect of different doses of biochar on NO emissions is still obscure. Here, we conducted a two-year field experiment to test the effects of different input amounts and frequencies of biochar on soil NO emissions in North China. Read More

Sci Rep 2020 Feb 11;10(1):2354. Epub 2020 Feb 11.

Department of Pediatric Dentistry and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.

Nitrous oxide, the least potent inhalation anesthetic, is widely used for conscious sedation. Recently, it has been reported that the occurrence of anesthetic-induced loss of consciousness decreases the interconnection between brain regions, resulting in brain network changes. However, few studies have investigated these changes in conscious sedation using nitrous oxide. Read More

Anesthesiology 2020 May;132(5):1017-1033

From the Centre for Human Psychopharmacology (A.P., L.K., D.L.) the Centre for Mental Health (W.W.), Swinburne University of Technology, Melbourne, Australia the Faculty of Information Technology, Monash University, Melbourne, Australia (L.K.) the Department of Anaesthesia and Pain Management, St. Vincent's Hospital Melbourne, Melbourne, Australia (J.C., S.M.) the School of Pharmacy, The University of Auckland, New Zealand (S.M.) the Department of Medicine, The University of Melbourne, Parkville, Melbourne, Australia (D.L.).

Background: Investigations of the electrophysiology of gaseous anesthetics xenon and nitrous oxide are limited revealing inconsistent frequency-dependent alterations in spectral power and functional connectivity. Here, the authors describe the effects of sedative, equivalent, stepwise levels of xenon and nitrous oxide administration on oscillatory source power using a crossover design to investigate shared and disparate mechanisms of gaseous xenon and nitrous oxide anesthesia.

Methods: Twenty-one healthy males underwent simultaneous magnetoencephalography and electroencephalography recordings. Read More

Ann Emerg Med 2020 Jun 24;75(6):735-743. Epub 2020 Jan 24.

Emergency Department, The Royal Children's Hospital, Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.

Study Objective: Intranasal fentanyl and inhaled nitrous oxide are increasingly combined to provide procedural sedation and analgesia in the pediatric emergency setting. This regimen is attractive because of its nonparenteral administration, but is associated with a higher incidence of vomiting than nitrous oxide alone. We seek to assess whether prophylactic oral ondansetron use could reduce the incidence of vomiting associated with intranasal fentanyl and nitrous oxide for procedural sedation compared with placebo. Read More

Mymensingh Med J 2020 Jan;29(1):136-141

Dr AKM Habibullah, Consultant, Department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

This study was designed to observe the haemodynamic changes, recovery status and cost effectiveness during anaesthesia in laparoscopic cholecystectomy with medical air in comparison to anaesthesia with nitrous oxide associated with maintain of adequate analgesia and was conducted in the department of Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2017 to June 2017. Nitrous oxide is popularly using as an analgesic in current balanced general anesthesia in addition carrier agent for anesthetic. Intraoperative pain intensity depends on many variables including, type of surgery, surgical stimulation and surgical incision. Read More

Med Gas Res 2019 Oct-Dec;9(4):213-220

Medical Research & Development, Healthcare World Business Line, Air Liquide Santé International, Paris Innovation Campus, Les Loges-en-Josas, France.

When administered in relatively high concentrations the mechanical properties of inhaled gas can become significantly different from air. This fact has implications in mechanical ventilation where adequate respiration and injury to the lungs or respiratory muscles can worsen morbidity and mortality. Here we use an engineering pressure loss model to analyze the administration of medical gas mixtures in newborns. Read More

Fish Shellfish Immunol 2020 Feb 17;97:248-256. Epub 2019 Dec 17.

Department of Aquatic Animals Diseases and Management, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, 13736, Egypt. Electronic address:

The effects of dietary administration of Astragalus membranaceus nanoparticles (ANP) on immune and anti-oxidative responses, growth performance and disease resistance of Oreochromis niloticus were evaluated in the present study. Fish were divided into three groups and received the ANP at rates of 0 (control), 1, and 2%/kg diet for four weeks. After the four-week feeding trial, three fish from each replicate were sampled for immune and anti-oxidative responses evaluation, ten fish from each group were challenged with A. Read More

Medicine (Baltimore) 2019 Dec;98(51):e18188

Department of Burns.

Aim: We compared the effects of 50% N2O and N2O titration in burn management to alleviate pain and anxiety associated with burn dressing.

Methods: In this single-blind prospective randomized controlled trial, 70 stable adult burn patients were randomized to 2 groups during May 2015 to January 2016. The experimental group was titrated with N2O ranging from 30% to the ideal sedation concentration before dressing change until the end. Read More

Environ Sci Pollut Res Int 2020 Jan 9;27(1):1118-1130. Epub 2019 Dec 9.

Key Laboratory of State Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed, College of Forestry, Jiangxi Agricultural University, Nanchang, 330045, China.

Coastal wetlands are crucial to global climate change due to their roles in modulating atmospheric concentrations of greenhouse gases (GHGs) (CO, CH, NO). Under a warming climate, we investigated spatial and temporal variations of GHGs emissions over the coastal wetlands in southeastern China during 2012-2014. Five dominant land cover types in coastal wetlands have been considered, including the bare mud flat (BF), the Spartina alterniflora flats (SAF), the Suaeda glauca flats (SGF), the Phragmites australis flat (PAF), and the Scripus triqueter flat (STF). Read More

Sci Total Environ 2020 Apr 3;711:134996. Epub 2019 Nov 3.

School of Public Administration, Zhejiang University of Finance and Economics, Hang Zhou 310018, China.

Three types of greenhouse gases (GHGs), namely carbon dioxide, methane and nitrous oxide emitted from reservoirs have an important but often ignored impact on the climate change. Based on the literature, this paper presents a comprehensive assessment of the long-term impact of GHGs generated by hydropower reservoirs, the systems for monitoring and assessing reservoir GHGs, the mechanism for their generation and key factors involved. Using limnology theory as a basis, the biogeochemical cycle of carbon in the environment is understood to be the main mechanism for generating reservoir based GHG emissions. Read More

Medicina (Kaunas) 2019 Dec 7;55(12). Epub 2019 Dec 7.

Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, Policlinico G. Martino, Via Consolare Valeria, 98100 Me, Italy.

Invasive dental procedures can be performed only with local anesthesia; in some cases, it may be useful to combine the administration of drugs to obtain anxiolysis with local anesthesia. Sedation required level should be individually adjusted to achieve a proper balance between the needs of the patient, the operator, and the safety of the procedure. Surgical time is an important factor for post-operative phases, and this could be greatly increased by whether the patient interrupts the surgeon or if it is not collaborative. Read More

J Clin Psychopharmacol 2020 Jan/Feb;40(1):80-83

From the Department of Addiction Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital.

Background: Nitrous oxide (N2O), a commonly used anesthetic agent in dentistry, has emerged as a global public health threat in young population. Although N2O-related neurological sequelae such as spinal cord degeneration and sensorimotor peripheral neuropathy are well known, psychiatric manifestations of heavy N2O use remain unclear. Here, we presented 7 treatment-seeking patients with severe N2O use disorder to delineate the psychiatric profiles of N2O users in Asia. Read More

J Conserv Dent 2019 Jul-Aug;22(4):356-361

Department of Conservative Dentistry and Endodontics, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.

Context: Anxiety and fear of pain are the two major deterrents for which patients avoid dental treatment. Local anesthetic, which forms the foundation for the delivery of pain-free endodontic treatment, does not serve the purpose in anxious patients and requires augmentation with other pharmacological agents.

Aims: The aim of this study is to observe the effectiveness of nitrous oxide in alleviating patient anxiety and pain during endodontic treatment of a vital tooth. Read More

BMJ Case Rep 2019 Nov 25;12(11). Epub 2019 Nov 25.

Internal Medicine, Haaglanden Medisch Centrum, The Hague, South-Holland, The Netherlands.

A 26-year-old man presented at the emergency department with confusion and decreased consciousness after several days of vomiting. In the preceding 6 months, he had used a 2-litre tank of nitrous oxide (NO) weekly. His metabolic encephalopathy was caused by hyperammonaemia which probably resulted from interference of NO-induced vitamin B deficiency with ammonia degradation. Read More

J Pak Med Assoc 2019 Nov;69(11):1596-1600

Department of Anesthesia, Aga Khan University, Karachi, Pakistan.

Objective: To compare the safety of laryngeal mask airway removal using two different deep anaesthesia techniques in paediatric patients.

Methods: The Randomized Control Trial was conducted at Aga Khan University Hospital, Karachi, from April 2012 to November 2013, and comprised patients aged 2-10 years scheduled for infraumbilical surgeries. Anaesthesia was induced with sevoflurane and later it was maintained by is oflurane, oxygen and nitrous oxide. Read More

Diagn Interv Imaging 2019 Dec 6;100(12):753-762. Epub 2019 Nov 6.

Saint Antoine Hospital, Sorbonne université, AP-HP, 75011 Paris, France.

The aims of this review were to describe the rationale and the techniques of sedation in interventional radiology, and to compile the safety and efficacy results available so far in the literature. A systematic MEDLINE/PubMed literature search was performed. Preliminary results from several studies demonstrated the feasibility, the efficacy and the safety of using sedative techniques in interventional radiology. Read More

J Pediatr Orthop B 2020 Mar;29(2):117-125

Pediatric Orthopedic Surgery Department, Regina Margherita Children's Hospital, Torino, Italy.

The management of Gartland type II supracondylar fractures remains controversial. This study aimed to evaluate the clinical, functional, and radiographic outcomes of Gartland type II supracondylar fractures treated by immediate closed reduction and casting in the emergency department using equimolar nitrous oxide as conscious sedation. All patients were treated non-operatively using equimolar nitrous oxide as conscious sedation during closed reduction and cast immobilization. Read More

Med J Aust 2019 11 17;211(9):429-429.e1. Epub 2019 Oct 17.

Health Protection NSW, NSW Health, Sydney, NSW.

Lakartidningen 2019 Oct 10;116. Epub 2019 Oct 10.

Helsingborgs lasarett - Anestesi och Intensivvård Helsingborg, Sweden Helsingborgs lasarett - Helsingborg, Sweden.

This study estimated the climate footprint of halogenated inhalation anesthetics in Sweden and estimated effects of a decreased use of these compounds. We collected data on sales of desflurane, sevoflurane and isoflurane in Sweden during 2017 and calculated the mass of CO2 equivalents (CO2e) using Global Warming Potential data over 100 years for the compounds. Inhalation anesthetics contributed by 5000 tons of CO2e which corresponds to 0. Read More

A A Pract 2019 Nov;13(10):379-381

From the Department of Anesthesiology, Aichi Children's Health and Medical Center, Aichi, Japan.

Pulmonary hypertension in children is commonly caused by underlying cardiac and pulmonary disease. Within the past 10 years, scurvy has been identified as a cause for pulmonary hypertension. We describe the case of a 3-year-old autistic boy with undiagnosed scurvy who was scheduled for cardiac catheterization. Read More

Vet Anaesth Analg 2019 Nov 23;46(6):807-814. Epub 2019 Aug 23.

Toronto Zoo, Scarborough, ON, Canada.

Objective: To evaluate the effects of midazolam and nitrous oxide (NO) on the minimum anesthetic concentration of isoflurane (MAC) in ball pythons.

Study Design: Prospective, crossover, randomized, semi-blinded study.

Animals: A total of nine healthy adult female ball pythons (Python regius) weighing 2. Read More

Environ Geochem Health 2020 Mar 28;42(3):915-931. Epub 2019 Sep 28.

College of Economics and Management, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, People's Republic of China.

Accurate forecasting is required to measure future national energy performance levels in order to establish clear policies for both monitoring and reducing Nitrous Oxide and other harmful emissions. Using the well-established and accepted measures, we predict the Nitrous Oxide emissions for the year 2030 based on actual data from the years 2000 to 2016 for six countries responsible for 61% of global emissions (China, Indonesia, India, Japan, Russia and the USA). Three advanced mathematical grey predictions models were employed, namely the Even Grey Model (1, 1), the Discrete Grey Model (1, 1) and the Non-homogeneous Discrete Grey Model, which is capable of working with poor or limited data. Read More

Tidsskr Nor Laegeforen 2019 Sep 9;139(12). Epub 2019 Sep 9.

Background: In July 2013, the Department of Paediatric and Adolescent Medicine at Østfold Hospital Trust introduced nitrous oxide as an option for procedural sedation of children and adolescents.

Material And Method: During the period 13 July 2013-25 August 2017, 311 procedures were performed with nitrous oxide in 238 patients aged 4-17 years. Age, sex, type and duration of procedure, any supplementary medications, complications and whether the procedure would previously have required general anaesthesia, were recorded in a form. Read More

Mol Neurobiol 2020 Jan 6;57(1):208-216. Epub 2019 Sep 6.

Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Mail Stop 8130, 12801 E. 17th Avenue, Rm L18-4100, Aurora, CO, 80045, USA.

A large number of preclinical studies have established that general anesthetics (GAs) may cause neurodevelopmental toxicity in rodents and nonhuman primates, which is followed by long-term cognitive deficits. The subiculum, the main output structure of hippocampal formation, is one of the brain regions most sensitive to exposure to GAs at the peak of synaptogenesis (i.e. Read More

Anesthesiology 2019 11;131(5):1063-1076

From the Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota (K.J.S.) Department of Anesthesiology, ThedaCare Regional Medical Center, Appleton, Wisconsin (B.M.M.) Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin (B.J.I., N.H., J.K.) Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, Pennsylvania (E.B.R.) Department of Preventive Medicine Biostatistics Faculty, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (A.-C.A.) the Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin (K.J.H.).

Background: Nitrous oxide can induce neurotoxicity. The authors hypothesized that exposure to nitrous oxide impairs axonal regeneration and functional recovery after central nervous system injury.

Methods: The consequences of single and serial in vivo nitrous oxide exposures on axon regeneration in four experimental male rat models of nervous system injury were measured: in vitro axon regeneration in cell culture after in vivo nitrous oxide administration, in vivo axon regeneration after sharp spinal cord injury, in vivo axon regeneration after sharp optic nerve injury, and in vivo functional recovery after blunt contusion spinal cord injury. Read More

Orthop Traumatol Surg Res 2019 10 22;105(6):1199-1204. Epub 2019 Aug 22.

Service de Chirurgie Pédiatrique, Hôpital Sud, Rennes University Hospital, 16 Boulevard de Bulgarie, 35200 Rennes, France. Electronic address:

Background: Upper limb injuries are common in children. When required, closed fracture reduction can be performed in the emergency department without general anaesthesia but causes pain. The primary objective of this study was to assess an oral analgesia protocol for fracture reduction without general anaesthesia. Read More

Anesthesiology 2019 Sep;131(3):533

J Craniofac Surg 2019 Nov-Dec;30(8):2549-2550

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology.

Objective: The aim of this study was to evaluate the efficiency of inhaled nitrous oxide (N2O) for manual reduction of acute nontraumatic temporomandibular joint (TMJ) dislocation in the supine position technique.

Methods: This clinical trial included a total of 51 patients presenting with acute nontraumatic TMJ dislocation. The patients were grouped randomly. Read More

J Anesth Hist 2019 04 29;5(2):36-43. Epub 2018 Aug 29.

Treadwell Library, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114.

Chemist and inventor Silas R. Divine (1838-1912) sold ammonium nitrate and other anesthesia supplies in New York City. He offered a carbon dioxide absorber for the purpose of rebreathing nitrous oxide. Read More

Emerg Med J 2019 Aug;36(8):506-508

Salford Royal NHS Foundation Trust, Salford, UK.

A short-cut review of the literature was carried out to establish whether inhaled methoxyflurane (Penthrox) is comparable or superior with a standard inhalational analgesia for the management of acute pain. Only two papers were identified as suitable for inclusion using the reported search strategy. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of the best papers are tabulated. Read More

Asian Spine J 2019 Dec 30;13(6):967-975. Epub 2019 Jul 30.

Department of Orthopaedics, Pt. Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India.

Study Design: Prospective, randomized, double blind, placebo-controlled study.

Purpose: To compare clonidine and pregabalin with placebo for the attenuation of postoperative pain after thoracolumbar spinal surgery and instrumentation.

Overview Of Literature: Spine surgery is associated with moderate to severe postoperative pain that needs to be controlled to improve patient's outcome. Read More

Trials 2019 Jul 4;20(1):399. Epub 2019 Jul 4.

Department of Pharmacology, Ningxia Medical University, 1160 Sheng Li Street, Yinchuan, 750004, China.

Background: The morbidity of knee arthritis is increasing among aged people and total knee arthroplasty has been its mainstream treatment to date. Postoperative rehabilitation is an important part of the procedure. However, the intense pain during the functional exercise involved has always been a challenge for both patients and health care professionals. Read More

Acad Emerg Med 2019 09 1;26(9):1102-1105. Epub 2019 Aug 1.

Department of Pediatrics, Division of Emergency Medicine, Emory University School of Medicine, Atlanta, GA.

Background: Nitrous oxide (N O) is an inhalational medication that has anxiolytic, amnestic, potent venodilatory and mild-to-moderate analgesic properties commonly used in the emergency department (ED) setting. N O has a rapid onset of action (<5 minutes) and recovery (<5 minutes) and can be quickly titrated to effect without the need for IV access. It has few side effects, does not require renal or hepatic metabolism for excretion and has no reports of allergic reaction. Read More

Ugeskr Laeger 2019 May;181(20)

This is a case report about two young men with extensive recreational use of nitrous oxide (N2O) in bulbs. Vitamin B12 deficiency was found in the first patient as well as signs of myelopathy on magnetic resonance imaging, and the second patient had acute liver injury. Physical examinations showed severe pathology with loss of motor function and affected sensory function in both patients. Read More

Anesth Analg 2020 03;130(3):730-739

Department of Otorhinolaryngology, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Prophylactic analgesic administration reduces pain behavior after pediatric bilateral myringotomy and pressure equalization tube placement (BMT). We hypothesized that postoperative pain in children treated with intraoperative ketorolac would, among several exposures of interest, be strongly associated with ear condition.

Methods: We conducted a retrospective cohort study of healthy children (9 months to 7 years) who underwent BMT at the Children's Hospital of Philadelphia or its ambulatory surgery centers from 2013 to 2016. Read More

Curr Opin Anaesthesiol 2019 Jun;32(3):285-290

Department of Anesthesia and Surgical Critical Care.

Purpose Of Review: The objective of this review is to analyze and summarize the current anesthetic methods used to alleviate pain and discomfort during transvaginal oocyte retrieval procedures (TORP), to try to reach practical recommendations, based on the evidence, which will translate into daily practice, the knowledge on the anesthetic management of patients scheduled for TORP.

Recent Findings: There is no strong evidence to recommend the avoidance of any technique or drug for TORP, including nitrous oxide or halogenated agents. Women should be offered any available technique. Read More

Anesth Essays Res 2019 Jan-Mar;13(1):44-49

Department of Anaesthesiology and Critical Care, JIPMER, Puducherry, India.

Background: The use of air oxygen mixture with isoflurane has become more common in the place of nitrous oxide, especially in laparoscopic and abdominal surgeries. With a varied mixture of gases and isoflurane used in general anesthesia, the exact dosing requirement and time duration of action have not been precisely studied with vecuronium when given as a bolus, as is given routinely.

Purpose: This study was undertaken to evaluate and compare the neuromuscular effect of vecuronium during anesthesia with oxygen, nitrous oxide and isoflurane versus oxygen, air and isoflurane. Read More

Pediatr Blood Cancer 2019 08 22;66(8):e27758. Epub 2019 Apr 22.

Department of Pediatric Hematology and Oncology, University Hospital of Caen, Caen, France.

Anesthesiology 2019 06;130(6):981-994

From the Department of Anesthesiology (N.L., N.A., C.K., Z.Z.) Department of Neurology (H.P.G.), University of Virginia Health System, Charlottesville, Virginia School of Medicine (R.S.) Department of Pharmacology and Neuroscience Graduate Program (K.A.S.) Department of Pharmacology (M.P.B.), University of Virginia, Charlottesville, Virginia.

Background: Previous studies suggest that rapid eye movement sleep rebound and disruption of rapid eye movement sleep architecture occur during the first 24 h after general anesthesia with volatile anesthetics in adult rats. However, it is unknown whether rapid eye movement sleep alterations persist beyond the anesthetic recovery phase in neonatal rats. This study tested the hypothesis that rapid eye movement sleep disturbances would be present in adolescent rats treated with anesthesia on postnatal day 7. Read More

Ann Emerg Med 2019 08 27;74(2):241-250. Epub 2019 Mar 27.

British Columbia Emergency Health Services, Vancouver, British Columbia, Canada.

Study Objective: We compare intranasal ketamine with intranasal placebo in providing pain reduction at 30 minutes when added to usual paramedic care with nitrous oxide.

Methods: This was a randomized double-blind study of out-of-hospital patients with acute pain who reported a verbal numeric rating scale (VNRS) pain score greater than or equal to 5. Exclusion criteria were younger than 18 years, known ketamine intolerance, nontraumatic chest pain, altered mental status, pregnancy, and nasal occlusion. Read More