Pain 2021 Dec 20. Epub 2021 Dec 20.
Inserm U987, APHP, CHU Ambroise Paré, UVSQ, Paris-Saclay, Boulogne-Billancourt, France CETD, CHU Cochin, APHP, Paris-Descartes University, Inserm U987, Paris, France Air Liquide Santé International, Les Loges en Josas, France Department of Neurology, University of Würzburg, Würzburg, Germany.
Abstract: Experimental studies have suggested that nitrous oxide-induced analgesia depends on interactions with opioids. On the basis of these results, we hypothesized that the effects of inhaled nitrous oxide/oxygen (N2O/O2) 50%-50% equimolar mixture (EMONO) on patients with neuropathic pain would be higher in those receiving concomitant opioids. To test this hypothesis, we did exploratory post hoc analyses of our recently published ProtoTOP study to compare the effects of EMONO and placebo in patients with or without concomitant opioid treatment. Read More