167,366 results match your criteria Nitric Oxide: Biology and Chemistry[Journal]


Effects of Hesperidin on H₂O₂-Treated Chondrocytes and Cartilage in a Rat Osteoarthritis Model.

Med Sci Monit 2018 Dec 17;24:9177-9186. Epub 2018 Dec 17.

Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).

BACKGROUND The purpose of this research was to investigate the effects of hesperidin on hydrogen peroxide (H₂O₂)-induced chondrocytes injury and cartilage degeneration in a rat model of osteoarthritis (OA). MATERIAL AND METHODS Chondrocytes were isolated from rat knee joints and treated with hesperidin alone or combined with H₂O₂. Then, Cell Counting Kit-8 (CCK-8) assay was used to assess cell viability. Read More

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December 2018
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Towards Understanding the Molecular Basis of Nitric Oxide-Regulated Group Behaviors in Pathogenic Bacteria.

J Innate Immun 2018 Dec 17:1-11. Epub 2018 Dec 17.

Pathogenic bacteria have many strategies for causing disease in humans. One such strategy is the ability to live both as single-celled motile organisms or as part of a community of bacteria called a biofilm. Biofilms are frequently adhered to biotic or abiotic surfaces and are extremely antibiotic resistant. Read More

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December 2018

Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by suppressing uric acid.

Biomed Pharmacother 2018 Dec 14;110:869-877. Epub 2018 Dec 14.

HOPE Cardiometabolic Research Team, Department of Physiology, College of Health Sciences, University of Ilorin, Nigeria. Electronic address:

Dipeptidyl peptidase-4 (DPP-4) inhibition has been shown to exert beneficial effects against insulin resistance (IR) and type 2 diabetes. Combined oral contraceptive (COC) treatment is associated with impaired glucose and lipid metabolism but the mechanisms are elusive. We therefore, hypothesized that DPP-4 inhibition ameliorates COC-induced glucose dysregulation and hepatic triglyceride (TG) accumulation through adenosine deaminase (ADA) /xanthine oxidase (XO) /uric acid-dependent pathway. Read More

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December 2018

Exhaled and nasal nitric oxide measurement in the evaluation of chronic cough.

Nitric Oxide 2018 Dec 14. Epub 2018 Dec 14.

Institute of Biomolecular Chemistry, National Research Council, 80078, Pozzuoli, Naples, Italy.

Chronic cough is one of the most common and troublesome nonspecific respiratory symptom for which patients seek a general practitioner and specialist advice. It is conventionally defined as a cough lasting for more than 8 weeks. Exhaled nitric oxide has proven to be a specific biomarker capable to discriminate between differential diagnoses of chronic cough and simultaneously provide information about the response to specific treatment. Read More

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December 2018

Is it possible to combine photodynamic therapy and application of dinitrosyl iron complexes in the wound treatment?

Nitric Oxide 2018 Dec 14. Epub 2018 Dec 14.

Department of Polymers and Composites, N.N.Semenov Institute of Chemical Physics, RAS, 4 Kosygin St., Moscow, 119991, Russia; Institute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya St., Moscow, 119991, Russia; Institute of Photonic Technologies, Research Center "Crystallography and Photonics", RAS, 2 Pionerskaya st., Troitsk, Moscow, 142190, Russia.

We have studied the effect of interactions between dinitrosyl iron complexes with thiol-containing ligands (DNIC-TL) and diglucamine salt of chlorine e6 (photoditazine, PD) on the rate of photosensitized oxidation of a model organic substrate - tryptophan - in the presence and absence of an amphiphilic polymer, Pluronic F127, as well as on the DNIC-TL and PD photostability. Using EPR and UV spectroscopy, we determined the rate constants for photodegradation of mono- and dinuclear DNIC-TL and PD, respectively. The presence of the photosensitizer and Pluronic F127 has been shown to have a negligible effect on the rate of photodestruction of mono- and dinuclear DNIC-TL, taking into account the changing DNIC-TL and PD concentrations in the photoexcitation conditions. Read More

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December 2018
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The Relationship of Exhaled Nitric Oxide with Ethnicity and Gender in Rural Georgia YouthAuthors.

Ann Allergy Asthma Immunol 2018 Dec 14. Epub 2018 Dec 14.

Department of Population Health Sciences, Augusta University, 1120 15th Street, Augusta, GA 30912.

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December 2018

Exposure to phthalates aggravates pulmonary function and airway inflammation in asthmatic children.

PLoS One 2018 17;13(12):e0208553. Epub 2018 Dec 17.

Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea.

Introduction: Studies on the associations between phthalate exposures and respiratory outcomes are limited. We investigated the association of phthalates exposure with pulmonary function and airway inflammation in asthmatic children.

Methods: Fifty-six children with asthma living in Seoul Metropolitan Area, Korea aged 6-16 years were enrolled. Read More

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December 2018

Investigation of galectin-3 levels in diabetic foot ulcers.

J Wound Care 2018 Dec;27(12):843-848

Professor, Harran University, School of Medicine, Department of Endocrinology, Sanliurfa, Turkey.

Objective:: It has been shown that galectin-3 (Gal-3) promotes angiogenesis and new vessel formation. Serum Gal-3 is a risk factor for vascular complications in type 2 diabetes. The aim of this study is to compare Gal-3 levels with a range of biochemical parameters. Read More

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December 2018

Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans.

Am J Physiol Heart Circ Physiol 2019 Jan 9;316(1):H106-H112. Epub 2018 Nov 9.

Department of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.

Continuous laminar shear stress increases the process of autophagy, activates endothelial nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOS), and generates NO in bovine and human arterial endothelial cells (ECs) compared with static controls. However, the translational relevance of these findings has not been explored. In the current study, primary ECs were collected from the radial artery of 7 men using sterile J-wires before (Pre) and after (Post) 60 min of rhythmic handgrip exercise (HG) performed with the same arm. Read More

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January 2019

Properties of oils from plantain pseudostem biotransformed using crude local enzyme sources: a comparison of poultry feed oil.

Recent Pat Food Nutr Agric 2018 Dec 17. Epub 2018 Dec 17.

Department of Biochemistry, University of Port Harcourt, Choba, Rivers State. Nigeria.

Objectives: Plantain pseudostem (PPS) wastes were biotransformed by applying simultaneous saccharification and fermentation (SSF) using excised snail digestive juice and yeast slurry, and their oil properties compared with oils from commercially sold poultry feeds (PF). Patents suggesting inclusion of certain additives (US20090226558A1), spices (US5741508A), cysteamine (US4711897A), and dextrin (US6326051B1) in animal diets are regarded as expensive, thus, requiring cheaper and readily available sources of growth.

Methods: The analysis of their free radical scavenging potentials was carried by spectrophotometry, while fatty acids, volatile fatty acids, essentials oils, and phytosterols were determined by chromatography. Read More

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December 2018

Nitric oxide is not just blowing in the wind.

Authors:
Louis J Ignarro

Br J Pharmacol 2019 Jan;176(2):131-134

UCLA School of Medicine, Beverly Hills, CA, USA.

Linked Articles: This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley. Read More

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January 2019

Metabonomic study of the protective effect of Fukeqianjin formula on multi-pathogen induced pelvic inflammatory disease in rats.

Chin Med 2018 10;13:61. Epub 2018 Dec 10.

1School of Medicine, Chengdu University, No. 2025, Cheng Luo Road, Chengdu, 610106 Sichuan People's Republic of China.

Background: Fukeqianjin formula has been effectively used in the treatment of pelvic inflammatory disease (PID) and the related complications in clinic. Although there have been some studies about the underlying mechanism that focus on its anti-inflammatory and immunoregulatory activities. But the mechanism is still not fully understood. Read More

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December 2018
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Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in -Infected Macrophages.

Front Immunol 2018 29;9:2792. Epub 2018 Nov 29.

Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.

Parasite recognition by Toll-like receptors (TLRs) contributes to macrophage activation and subsequent control of infection through the coordinated production of pro-inflammatory and microbicidal effector molecules. The modulation of microRNA (miRNA) expression by infection potentially mediates the post-transcriptional regulation of the expression of genes involved in leishmanicidal activity. Here, the contribution of TLR signaling to the miRNA profile and gene expression was evaluated in -infected murine macrophages. Read More

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November 2018

Proteomic Analysis of Hemocytes During Encapsulation of Sporocysts.

Front Immunol 2018 29;9:2773. Epub 2018 Nov 29.

Department of Pathobiological Sciences, University of Wisconsin, Madison, WI, United States.

Circulating hemocytes of the snail , a major intermediate host for the blood fluke , represent the primary immune effector cells comprising the host's internal defense system. Within hours of miracidial entry into resistant strains, hemocytes infiltrate around developing sporocysts forming multi-layered cellular capsules that results in larval death, typically within 24-48 h post-infection. Using an model of hemocyte-sporocyst encapsulation that recapitulates events, we conducted a comparative proteomic analysis on the responses of hemocytes from inbred strains during the encapsulation of primary sporocysts. Read More

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November 2018

Coupled Carbon, Sulfur, and Nitrogen Cycles Mediated by Microorganisms in the Water Column of a Shallow-Water Hydrothermal Ecosystem.

Front Microbiol 2018 13;9:2718. Epub 2018 Nov 13.

State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China.

Shallow-water hydrothermal vent ecosystems are distinctly different from deep-sea vents, as other than geothermal, sunlight is one of their primary sources of energy, so their resulting microbial communities differ to some extent. Yet compared with deep-sea systems, less is known about the active microbial community in shallow-water ecosystems. Thus, we studied the community compositions, their metabolic pathways, and possible coupling of microbially driven biogeochemical cycles in a shallow-water hydrothermal vent system off Kueishantao Islet, Taiwan, using high-throughput 16S rRNA sequences and metatranscriptome analyses. Read More

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November 2018

Ischemic Preconditioning Preserves Liver Energy Charge and Function on Hepatic Ischemia/Reperfusion Injury in Rats.

Arch Med Res 2018 Dec 13. Epub 2018 Dec 13.

División de Investigación Quirúrgica, Centro de Investigación Biomédica de Occidente, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México; Farmacología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.

Background: Cell energy during ischemia/reperfusion depends on mechanisms including adenosine diphosphate degradation, oxygen species and cytokine liberation, neutrophil infiltration, and endothelial dysfunction. Preconditioning-a brief ischemic episode that confers a state of protection against subsequent ischemia-reperfusion injury-involves NO and adenosine production, reduction in oxygen species liberation, and preservation of microcirculation. During hypoxia, constitutive NO production assures adequate oxygen delivery and reduced energy loss. Read More

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December 2018

Reduced Plasma Kallistatin Is Associated With the Severity of Coronary Artery Disease, and Kallistatin Treatment Attenuates Atherosclerotic Plaque Formation in Mice.

J Am Heart Assoc 2018 Nov;7(21):e009562

2 Department of Biochemistry and Molecular Biology Medical University of South Carolina Charleston SC.

Background Kallistatin exerts beneficial effects on organ injury by inhibiting oxidative stress and inflammation. However, the role of kallistatin in atherosclerosis is largely unknown. Here, we investigated the role and mechanisms of kallistatin in patients with coronary artery disease ( CAD ), atherosclerotic plaques of apoE mice, and endothelial activation. Read More

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November 2018

Elevated levels of serum nitrite and nitrate, NOx, are associated with increased total and cardiovascular mortality in an 8-year follow-up study.

Eur J Clin Invest 2018 Dec 16:e13061. Epub 2018 Dec 16.

National Medical Research Center for Preventive Medicine of the Ministry of Healthcare of Russian Federation, 10 Petroverigsky per., Building 3, Moscow, 101990, Russia.

Background: Nitric oxide (NO) is one of the key regulators of vascular function. Abnormal NO signaling is linked to various cardiovascular diseases. We studied associations between circulating levels of nitric oxide metabolites, nitrite and nitrate (NOx), and total and cardiovascular mortality in a prospective 8-year follow-up cohort study in 1869 patients aged over 55 years. Read More

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December 2018

The effects of a 12-week jump rope exercise program on abdominal adiposity, vasoactive substances, inflammation, and vascular function in adolescent girls with prehypertension.

Eur J Appl Physiol 2018 Dec 15. Epub 2018 Dec 15.

Department of Physical Education, Pusan National University, Busan, South Korea.

Introduction: Childhood obesity is strongly associated with cardiovascular disease (CVD) development. It is necessary to combat unfavorable outcomes of obesity at a young age by utilizing effective interventions, such as exercise.

Purpose: We sought to examine the effects of a jump rope exercise program on CVD risk factors, including body composition, vasoactive substances, inflammation, and vascular function in prehypertensive adolescent girls. Read More

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December 2018
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Photoacoustic microscopy of obesity-induced cerebrovascular alterations.

Neuroimage 2018 Dec 13. Epub 2018 Dec 13.

Department of Biomedical Engineering, University of Virginia, Charlottesville, USA. Electronic address:

Cerebral small vessel disease has been linked to cognitive, psychiatric and physical disabilities, especially in the elderly. However, the underlying pathophysiology remains incompletely understood, largely due to the limited accessibility of these small vessels in the live brain. Here, we report an intravital imaging and analysis platform for high-resolution, quantitative and comprehensive characterization of pathological alterations in the mouse cerebral microvasculature. Read More

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December 2018

Anthriscus sylvestris root extract reduces allergic lung inflammation by regulating interferon regulatory factor 4-mediated Th2 cell activation.

J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Korea; Department of Pathology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do, 26339, Korea. Electronic address:

Ethnopharmacological Relevance: Anthriscus sylvestris L. Hoffmann (AS) is a perennial plant that grows in Asia and Eastern Europe. Its dried root is used to treat conditions such as asthma, bronchitis, and cough. Read More

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December 2018
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Astaxanthin ameliorates scopolamine-induced spatial memory via reduced cortical-striato-hippocampal oxidative stress.

Brain Res 2018 Dec 12. Epub 2018 Dec 12.

Department of General and Experimental Psychology, Ludwig-Maximilians-Universität München, Germany. Electronic address:

Alzheimer's disease is characterized by progressive disruption of cholinergic neurotransmission and impaired cognitive functions. In rodents, scopolamine has been used to induce cholinergic dysfunction resulting in cognitive impairments and an increment of oxidative stress in the brain. Here we tested whether oxidative stress can be attenuated via an antioxidant (astaxanthin) to rescue scopolamine-induced spatial memory. Read More

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December 2018
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Microwave-Assisted Digestion Procedures Using Diluted Oxidant Mixture for Elemental Analysis of Crustaceans by MIP OES.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Group of Analytical Spectrometry Applied, Faculty of Chemistry, Federal University of Pará, Belém, Pará, 66075-110, Brazil.

The aim of this study was to evaluate three digestion procedures using a diluted oxidant mixture of nitric acid, hydrogen peroxide, and water for determination of Cu, Fe, K, Mg, Mn, and Zn in shrimp and crab samples from Northern Brazil by microwave-induced plasma optical emission spectrometry. The efficiency of the digestion procedure was evaluated by comparing the residual carbon content, residual acidity, and elemental concentrations obtained in the samples. Digestion procedure 2 (4 mL HNO + 4 mL HO + 4 mL HO) was chosen due the adequate residual carbon content (5. Read More

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December 2018

Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells.

Immunity 2018 Dec 4. Epub 2018 Dec 4.

Center for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

Salmonella enterica (Se) bacteria cause persistent intracellular infections while stimulating a robust interferon-γ-producing CD4 T (Th1) cell response. We addressed this paradox of concomitant infection and immunity by tracking fluorescent Se organisms in mice. Se bacteria persisted in nitric oxide synthase (iNOS)-producing resident and recruited macrophages while inducing genes related to protection from nitric oxide. Read More

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December 2018

Aphrodisiac effect of Hunteria umbellata seed extract: Modulation of nitric oxide level and arginase activity in vivo.

Pathophysiology 2018 Dec 5. Epub 2018 Dec 5.

Functional Foods and Nutraceutical Research Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, 340001, Nigeria.

Hunteria umbellata has been reported useful in managing the male sexual related disorder, but there is a dearth of information on its possible mechanism of action. Hence, this study was designed to investigate the effect of H. umbellata on some sexual behavior parameters in male rats, in order to ascertain its acclaimed aphrodisiac property. Read More

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December 2018
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Insect heart rhythmicity is modulated by evolutionarily conserved neuropeptides and neurotransmitters.

Curr Opin Insect Sci 2018 Oct 11;29:41-48. Epub 2018 Jun 11.

Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA. Electronic address:

Insects utilize an open circulatory system to transport nutrients, waste, hormones and immune factors throughout the hemocoel. The primary organ that drives hemolymph circulation is the dorsal vessel, which is a muscular tube that traverses the length of the body and is divided into an aorta in the head and thorax, and a heart in the abdomen. The dorsal vessel is myogenic, but its rhythmicity is modulated by neuropeptides and neurotransmitters. Read More

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October 2018

Eicosapentaenoic Acid and Vitamin E Against Doxorubicin Induced Cardiac and Renal Damages: Role of Cytochrome c and iNOS.

Arch Iran Med 2018 Nov 1;21(11):502-508. Epub 2018 Nov 1.

Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, Egypt.

Background: The current study aimed to evaluate the mechanisms involved in protection against doxorubicin-induced cardiac and renal toxicities upon treatment with eicosapentaenoic acid and vitamin E.

Methods: Rats were randomly assigned to 4 groups: normal control, doxorubicin inducted control, eicosapentaenoic acid treated group and a final group pretreated with vitamin E. Lipid peroxidation, reduced glutathione (GSH) and tumor necrosis factor-alpha (TNF-α) contents as well as glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) activities were assessed. Read More

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November 2018

Effect of gemfibrozil on cardiotoxicity induced by doxorubicin in male experimental rats.

Biomed Pharmacother 2019 Jan 6;109:530-535. Epub 2018 Nov 6.

Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Electronic address:

Cardiotoxicity is an adverse effect of the anticancer drug doxorubicin (DOX). Gemfibrozil (GEM) is a lipid-lowering drug with a number of biological properties such as anti-inflammatory and antioxidant activities. Therefore, we decided to investigate the effect of GEM on DOX-induced cardiotoxicity in rats. Read More

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January 2019
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Cardiac and pulmonary toxicity of mesoporous silica nanoparticles is associated with excessive ROS production and redox imbalance in Wistar rats.

Biomed Pharmacother 2019 Jan 3;109:2527-2538. Epub 2018 Dec 3.

Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Egypt.

Mesoporous silica nanoparticles (MSNs) represent one of the most promising drug delivery systems. MSNs have attracted considerable attention in recent years both in industry and biomedicine due to their unique properties. Thus, evaluation of the toxic effects of MSNs is necessary before the biomedical and clinical applications. Read More

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January 2019

Endothelium-dependent and endothelium-independent vasorelaxant effects of tiliacorinine 12'-O-acetate and mechanisms on isolated rat aorta.

Biomed Pharmacother 2019 Jan 26;109:2090-2099. Epub 2018 Nov 26.

Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center for Research and Development of Natural Products for Health, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Tiliacorinine 12'-O-acetate is a modified analog of Tiliacorinine, a major compound in Tiliacora triandra. The present study explored the vasorelaxation property of tiliacorinine 12'-O-acetate and its mechanism in isolated rat aorta using the organ bath technique. Tiliacorinine 12'-O-acetate exhibited concentration-dependent (10-10 M) vasorelaxation in endothelium-intact rings (E = 93. Read More

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January 2019
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2.023 Impact Factor

Protection afforded by methanol extract of Calotropis procera latex in experimental model of colitis is mediated through inhibition of oxidative stress and pro-inflammatory signaling.

Biomed Pharmacother 2019 Jan 15;109:1602-1609. Epub 2018 Nov 15.

Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India.

Calotropis procera, a latex producing plant is known to possess medicinal properties including its beneficial effect in gastrointestinal disorders. The anti-inflammatory effect of its latex in various experimental models is noteworthy and in light of this the present study was carried out with an objective to evaluate its efficacy in ulcerative colitis, an inflammatory condition of the colon. Colitis was induced in rats by acetic acid and the rats were divided into four groups where one group served as experimental control and the other groups were treated with two doses of methanol extract of dried latex of C. Read More

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January 2019

Luteolin inhibits IL-1β-induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model.

Biomed Pharmacother 2019 Jan 26;109:1586-1592. Epub 2018 Nov 26.

Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu, China.

Osteoarthritis (OA) is a joint disease characterized by inflammation and cartilage degradation. Accumulating evidence has demonstrated that luteolin, a natural flavonoid, has anti-inflammatory and anticatabolic effects. The present study aimed to assess the protective effect of luteolin on interleukin (IL)-1β-stimulated rat chondrocytes and a monosodium iodoacetate (MIA)-induced model of OA. Read More

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January 2019

Impact of Time to Neonatal Transport on Outcomes of Transient Tachypnea of the Newborn.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan.

Objective:  To assess effects of neonatal transport on transient tachypnea of the newborn (TTN) in outborn term neonates.

Study Design:  This retrospective cohort study included 66 term neonates diagnosed with TTN and transported to the Osaka Women's and Children's Hospital neonatal intensive care unit between January 2003 and March 2018. A multivariate logistic regression analysis identified perinatal and neonatal transport factors associated with adverse short-term outcomes defined as mechanical ventilation >48 hours, continuous positive airway pressure >72 hours, pulmonary hemorrhage, and requirement for inhaled nitric oxide, thoracentesis, or surfactant replacement therapy. Read More

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December 2018
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The protective effect of sophocarpine in osteoarthritis: An in vitro and in vivo study.

Int Immunopharmacol 2018 Dec 11;67:145-151. Epub 2018 Dec 11.

Department of Anesthesiology, The Second Affiliated Hospital of Wen Zhou Medical University, 109, Xueyuanxi Road, 325027 Wenzhou, China. Electronic address:

Background: Osteoarthritis (OA) is a type of degenerative joint disease affecting millions of individuals worldwide. However, there are currently no great inflammatory treatments available for it. Sophocarpine (SPC), one of the key bioactive compounds derived from Sophora flavescens, has shown remarkable anti-inflammatory effects. Read More

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December 2018
2 Reads

The protective effect of zeranol in cerebral ischemia reperfusion via p-CREB overexpression.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt. Electronic address:

Aims: Cerebral ischemia reperfusion (I/R) is a neurovascular disease leading to cerebral damage. It was found that postmenopausal women are liable to more dangerous effects than men at same age in stroke. The objective of this study is to investigate the neuroprotective effect of zeranol against cerebral ischemia reperfusion in ovariectomized rats. Read More

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December 2018

Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR-/- mice.

Nanomedicine 2018 Dec 11. Epub 2018 Dec 11.

Institute of Physiology II, University of Münster, Münster, Germany; Institute of Physiology, University of Lübeck, Lübeck, Germany. Electronic address:

Endothelial dysfunction is recognized as a critical condition in the development of cardiovascular disorders. This multifactorial process involves changes in the biochemical and mechanical properties of endothelial cells leading to disturbed release of vasoprotective mediators. Hypercholesterolemia and increased stiffness of the endothelial cortex are independently shown to result in reduced release of nitric oxide and thus endothelial dysfunction. Read More

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December 2018
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[The application of preoperative pulmonary function and FeNO test in patients with chronic rhinosinusitis].

Authors:
Y Liu A H Yan

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1788-1791

Department of Otorhinolaryngology, the First Hospital of China Medical University, Shenyang, 110001, China.

To explore the application of lung function and exhaled nitric oxide in the evaluation of patients with chronic rhinosinusitis(CRS) with or without polyps who denied bronchial asthma history and planned to undergo endoscopic sinus surgery. Two hundred and thirty-two patients with CRS during April 2016 to April 2018 in our hospital were recruited in this study. All patients accepted lung function and exhaled nitric oxide test before surgery to evaluate whether accompanied with asthma, improvements after standardized drug therapy in patients with asthma. Read More

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December 2018

Novel Calix[4]arene-based Bis-Nitric Oxide Complexes: Synthesis, Physical Properties and Structural Characterization.

Chem Asian J 2018 Dec 14. Epub 2018 Dec 14.

Marquette University, Chemistry, 535 N 14th St, 53233, Milwaukee, UNITED STATES.

Calix[4]arene-based molecules have proven to be excellent candidates for nitric oxide (NO) sensors and storage materials due to their unprecedented binding affinity for NO. However, the structure of calix[4]arene is complicated by the presence of four possible conformers: 1,3-alternate, 1,2-alternate, cone and partial cone (paco). While prior studies have established the structure of the complexes of NO with several of these conformers, the 1,2-alternate conformer complex, i. Read More

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December 2018

Characterization of peristaltic motility in the striated muscle portion of the esophagus using a novel in vivo method in rats.

Neurogastroenterol Motil 2018 Dec 14:e13518. Epub 2018 Dec 14.

Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.

Background: Esophageal peristalsis is controlled by the brainstem via vago-vagal reflex. However, the precise regulatory mechanisms in the striated muscle portion are largely unknown. The aim of this study was to characterize peristaltic motility in the portion of the esophagus using a novel in vivo method in rats. Read More

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December 2018
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The milk thistle (Silybum marianum) compound Silibinin stimulates leukopoiesis from mouse embryonic stem cells.

Phytother Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany.

The milk thistle compound Silibinin (i.e., a 1:1 mixture of Silybin A and Silybin B) stimulates vasculogenesis of mouse embryonic stem (ES) cells. Read More

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December 2018

Uranium exposure increases spermatocytes metaphase apoptosis in rats: inhibitory effect of thymoquinone and N-acetylcysteine.

Gen Physiol Biophys 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Physiology, Department of Zoology, Faculty of Sciences, Assiut University, Assiut, Egypt.

Uranyl acetate (UA), a commercial stock from depleted uranium (DU), has a combined effect of chemical toxicity and mild radioactivity. Here, we investigated the potential antioxidant, antiapoptotic and cytoprotective effects of thymoquinone (TQ) and N-acetylcysteine (NAC) against UA-induced testicular damage in rats. UA reduced testicular superoxide dismutase (SOD) activity and nitric oxide (NO) and glutathione (GSH) levels relative to the control group. Read More

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December 2018

Increased IL-1β levels are associated with an imbalance of "oxidant/antioxidant" status during Behçet's disease.

Eur Cytokine Netw 2018 Sep;29(3):95-102

USTHB, "Cytokines and NO Synthases" team, LBCM, FSB, BP 32, El Alia, 16111, Bab ezzouar, Algiers, Algeria.

Behçet's disease is a multisystem disease. It stands at the crossroad between the autoimmunity and auto-inflammatory disorders. In this study, we sought to address a relationship that might exist between interleukin-1β (IL-1β) and the oxidants/antioxidants markers in Behçet's patients. Read More

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September 2018
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Practice Variation, Costs and Outcomes Associated with the Use of Inhaled Nitric Oxide in Pediatric Heart Transplant Recipients.

Pediatr Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Vanderbilt University, 2200 Children's Way, Suite 5230 DOT, Nashville, TN, 37232-9119, USA.

Right ventricular (RV) failure is a potentially fatal complication following heart transplantation (HTx). Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator that is used to decrease pulmonary vascular resistance immediately post-HTx to reduce the risk of RV failure. The aim of this study was to describe utilization patterns, costs, and outcomes associated with post-transplant iNO use in children. Read More

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December 2018
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The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone.

Inflammation 2018 Dec 14. Epub 2018 Dec 14.

Postgraduate Program of Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.

Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could attenuate peripheral inflammatory and oxidative stress potentially triggered ZIP. Read More

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December 2018

Ginsenoside Rf alleviates dysmenorrhea and inflammation through the BDNF-TrkB-CREB pathway in a rat model of endometriosis.

Food Funct 2018 Dec 14. Epub 2018 Dec 14.

Department of Obstetrics and Gynecology, Shandong University QiLu Hospital, 104 culture west Road, Jinan 250012, Shandong, China.

To investigate the effects and the underlying mechanisms of ginsenoside Rf in a surgically induced rat endometriosis model, endometriosis was constructed through homologous transplantation and the Wistar rats were further randomly classified into the sham group, the estradiol valerate (E2V) control group, the endometriosis group, and the ginsenoside Rf groups (1.0, 2.0 and 4. Read More

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December 2018

Neptunium(iv)-hydroxamate complexes: their speciation, and kinetics and mechanism of hydrolysis.

Dalton Trans 2018 Dec 14. Epub 2018 Dec 14.

National Nuclear Laboratory, Central Laboratory, Sellafield, Cumbria CA20 1PG, UK.

Simple hydroxamic acids such as acteohydroxamic acid (AHA) have been identified as suitable reagents for the control of Pu and Np in advanced separation processes for nuclear fuel reprocessing such as the Advanced PUREX or UREX based recycle processes, due to their ability to strip the tetravalent form of Pu and Np from tri-butyl phosphate into nitric acid. However, both free and metal bound hydroxamates are known to undergo acid catalysed hydrolysis at low pH, the kinetics of which must be characterised before implementation of PUREX/UREX based reprocessing flowsheets. In support of this implementation, a comprehensive thermodynamic and kinetic model that describes both the complex speciation and hydrolysis of AHA in the presence of Np(iv) has been developed. Read More

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December 2018

Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells.

Biomed Rep 2018 Dec 18;9(6):511-516. Epub 2018 Oct 18.

Department of Physiology and Biochemistry, Princess Basma Teaching Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid 21110, Jordan.

Previous studies have shown that progesterone could inhibit muscle contraction in various sites of the gastrointestinal tract. The underlying mechanisms responsible for these inhibitory effects of progesterone are not fully known. The aim of the current study was to investigate the effect of progesterone on the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway and muscle contraction in the stomach. Read More

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December 2018

Effects of aspirin combined with cilostazol on thromboangiitis obliterans in diabetic patients.

Exp Ther Med 2018 Dec 8;16(6):5041-5046. Epub 2018 Oct 8.

Department of Blood Transfusion, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

The present study explored the effects of aspirin combined with cilostazolin in the treatment of diabetic patients with thromboangiitis obliterans and the effects on the related inflammatory factors. A total of 90 diabetic patients with thromboangiitis obliterans admitted to Weifang People's Hospital from August 2015 to June 2017 were selected and divided into the control group (n=45) and the combination group (n=45). Patients in the control group were given aspirin, and those in the combination group were given aspirin combined with cilostazol. Read More

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December 2018

Associating HOand NO-related changes in the proteome of Mycobacterium smegmatis with enhanced survival in macrophage.

Emerg Microbes Infect 2018 Dec 13;7(1):212. Epub 2018 Dec 13.

Division of Chemical & System Biology, Department of Integrative Biomedical Science, University of Cape Town, Cape Town, South Africa.

Mycobacterium manages to evade the host cell immune system, partially owing to its ability to survive redox stress after macrophage engulfment. Exposure to redox stress has been linked to later replication, persistence, and latent infection. In this work, mass spectrometry was used to elucidate the cell-wide changes that occur in response to sublethal doses of hydrogen peroxide and nitric oxide over time, with Mycobacterium smegmatis being used as a model organism. Read More

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December 2018
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Risk stratification and medical therapy of pulmonary arterial hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Cardiovascular Medicine, The University of Michigan, Ann Arbor, MI, USA.

Pulmonary arterial hypertension (PAH) remains a severe clinical condition despite the availability over the past 15 years of multiple drugs interfering with the endothelin, nitric oxide and prostacyclin pathways. The recent progress observed in medical therapy of PAH is not, therefore, related to the discovery of new pathways, but to the development of new strategies for combination therapy and on escalation of treatments based on systematic assessment of clinical response. The current treatment strategy is based on the severity of the newly diagnosed PAH patient as assessed by a multiparametric risk stratification approach. Read More

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December 2018
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