6 results match your criteria Nitric Oxide: Biology and Chemistry[Journal]

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Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria.

Chemistry 2016 06 3;22(24):8158-66. Epub 2016 May 3.

Department of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, Florida, 32610, USA.

A new dimeric macrolide xylopyranoside, cocosolide (1), was isolated from the marine cyanobacterium preliminarily identified as Symploca sp. from Guam. The structure was determined by a combination of NMR spectroscopy, HRMS, X-ray diffraction studies and Mosher's analysis of the base hydrolysis product. Read More

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http://dx.doi.org/10.1002/chem.201600674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224530PMC
June 2016
31 Reads

Sensitization of NO-Releasing Ruthenium Complexes to Visible Light.

Chemistry 2015 Oct 23;21(44):15554-63. Epub 2015 Sep 23.

Abbe Center of Photonics, Friedrich Schiller University Jena (Germany).

We report a combined spectroscopical-theoretical investigation on the photosensitization of transition metal nitrosyl complexes. For this purpose, ruthenium nitrosyl complexes based on tetradentate biscarboxamide ligands were synthesized. A crystal structure analysis of a lithium-based ligand intermediate is described. Read More

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http://dx.doi.org/10.1002/chem.201502091DOI Listing
October 2015
6 Reads

Rhenium(I) polypyridine diamine complexes as intracellular phosphorogenic sensors: synthesis, characterization, emissive behavior, biological properties, and nitric oxide sensing.

Chemistry 2014 Jul 1;20(31):9633-42. Epub 2014 Jul 1.

Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (P.R. China), Fax: (852) 3442-0522.

We report the development of a series of rhenium(I) polypyridine complexes appended with an electron-rich diaminoaromatic moiety as phosphorogenic sensors for nitric oxide (NO). The diamine complexes [Re(N^N)(CO)3 (py-DA)][PF6 ] (py-DA=3-(N-(2-amino-5-methoxyphenyl)aminomethyl)pyridine; N^N=1,10-phenanthroline (phen) (1 a), 3,4,7,8-tetramethyl-1,10-phenanthroline (Me4 -phen) (2 a), 4,7-diphenyl-1,10-phenanthroline (Ph2 -phen) (3 a)) have been synthesized and characterized. In contrast to common rhenium(I) diimines, these diamine complexes were very weakly emissive due to quenching of the triplet metal-to-ligand charge-transfer ((3) MLCT) emission by the diaminoaromatic moiety through photoinduced electron transfer (PET). Read More

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http://dx.doi.org/10.1002/chem.201402502DOI Listing
July 2014
12 Reads

A small-molecule two-photon probe for nitric oxide in living tissues.

Chemistry 2012 Sep 21;18(39):12388-94. Epub 2012 Aug 21.

Division of Energy Systems Research, Ajou University, Suwon, 443-749 Korea.

Two-photon microscopy (TPM) has become an indispensable tool in the study of biology and medicine due to the capability of this method for molecular imaging deep inside intact tissues. For the maximum utilization of TPM, a variety of two-photon (TP) probes for specific applications are needed. In this article, we report a small-molecule TP probe (ANO1) for nitric oxide (NO) that shows a rapid and specific NO response, a 68-fold fluorescence enhancement in response to NO, and a maximum TP-action cross-section of 170 GM (GM: 10(-50) cm(4) photon(-1)) upon reaction with excess NO. Read More

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http://doi.wiley.com/10.1002/chem.201201197
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http://dx.doi.org/10.1002/chem.201201197DOI Listing
September 2012
20 Reads

Oxygen atom transfer from a trans-dioxoruthenium(VI) complex to nitric oxide.

Chemistry 2012 Jan 2;18(1):138-44. Epub 2011 Dec 2.

Department of Biology and Chemistry and Institute of Molecular Functional Materials, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, P.R. China.

In aqueous acidic solutions trans-[Ru(VI)(L)(O)(2)](2+) (L=1,12-dimethyl-3,4:9,10-dibenzo-1,12-diaza-5,8-dioxacyclopentadecane) is rapidly reduced by excess NO to give trans-[Ru(L)(NO)(OH)](2+). When ≤1 mol equiv NO is used, the intermediate Ru(IV) species, trans-[Ru(IV)(L)(O)(OH(2))](2+), can be detected. The reaction of [Ru(VI)(L)(O)(2)](2+) with NO is first order with respect to [Ru(VI)] and [NO], k(2)=(4. Read More

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http://dx.doi.org/10.1002/chem.201102297DOI Listing
January 2012
12 Reads

On the mechanism of action of fullerene derivatives in superoxide dismutation.

Chemistry 2010 Mar;16(10):3207-14

Institut de Química Computacional and Departament de Química, Universitat de Girona, Campus Montilivi, 17071 Girona, Spain.

We have studied the mechanism of the antioxidant activity of C(60) derivatives at the BP86/TZP level with inclusion of solvent effects (DMSO) by using the COSMO approach. The reaction studied here involves degradation of the biologically relevant superoxide radical (O(2)(*-)), which is linked to tissue damage in several human disorders. Several fullerene derivatives have experimentally been shown to be protective in cell culture and animal models of injury, but precisely how these compounds protect biological systems is still unknown. Read More

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http://dx.doi.org/10.1002/chem.200902728DOI Listing
March 2010
7 Reads
2 Citations
5.731 Impact Factor
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