5,142 results match your criteria Nippon Yakurigaku Zasshi Folia Pharmacologica Japonica[Journal]


[A new approach to prevent the chemotherapy-induced peripheral neuropathy].

Nihon Yakurigaku Zasshi 2019 ;153(4):200

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http://dx.doi.org/10.1254/fpj.153.200DOI Listing
January 2019

[Microglia subtype and brain functions].

Nihon Yakurigaku Zasshi 2019 ;153(4):199

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http://dx.doi.org/10.1254/fpj.153.199DOI Listing
January 2019

[Pharmacological and clinical effects of letermovir (Prevymis), a novel anti-human cytomegalovirus prophylactic drug].

Nihon Yakurigaku Zasshi 2019 ;153(4):192-198

Clinical Research, Japan Development, MSD K.K.

Letermovir is an anti-human cytomegalovirus (HCMV) drug with a novel mechanism of action. Virological characterization and sequence analysis of resistant viruses indicate that the viral DNA terminase complex is the target of this compound. Unlike currently marketed anti-HCMV drugs, which act via inhibition of the viral DNA polymerase, the terminase inhibitor interferes with viral DNA cleavage and packaging of monomeric genome units into capsids. Read More

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http://dx.doi.org/10.1254/fpj.153.192DOI Listing
January 2019

[In silico prediction models of the induction of drug-metabolizing enzymes for drug discovery].

Nihon Yakurigaku Zasshi 2019 ;153(4):186-191

Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical Co., Ltd.

Drug metabolism in the liver is a major factor affecting pharmacokinetics of drugs, and cytochrome P450s (P450s) are major enzymes responsible for it. Since drug-drug interactions (DDIs) can affect the pharmacokinetics of concomitantly administrated drugs, it may limit the drug therapy such as dose adjustment and contraindications for co-administration and lead to dose adjustment and contraindications for co-administration. DDI is thus one of the risk factors to be reduced in the lead-optimization stage. Read More

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http://dx.doi.org/10.1254/fpj.153.186DOI Listing
January 2019
2 Reads

[The senescence-accelerated mouse as a model for geriatrics and aging biology].

Nihon Yakurigaku Zasshi 2019 ;153(4):179-185

Department of Biological Sciences for Intractable Neurological Diseases, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University.

Rapid expansion of aged population is predicted worldwide. To cope with problems expected from this situation and extend the period of active and healthy life of people as much as possible, it is important to elucidate not only the biological mechanisms of "aging", but also the etiology of various "age-related diseases". To attain this goal, extensive studies using excellent animal models are indispensable. Read More

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http://dx.doi.org/10.1254/fpj.153.179DOI Listing
January 2019
1 Read

[The functional role of endogenous APJ agonists; Apelin and Elabela/Toddler in cardiovascular diseases].

Nihon Yakurigaku Zasshi 2019 ;153(4):172-178

Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine.

Apelin is an endogenous peptide ligand for APJ receptor, which is widely expressed in human body, and exerts various physiological effects such as vasodilation, inotropic effect, water balance, heart development, angiogenesis and energy metabolism. The beneficial effects of Apelin in cardiovascular diseases have been elucidated, and the roles of Apelin in aging-associated diseases are recently implicated. The mechanisms for therapeutic effects of Aplein include an antagonistic action to renin-angiotensin system (RAS) in addition to inotropic and vasodilatory actions. Read More

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http://dx.doi.org/10.1254/fpj.153.172DOI Listing
January 2019
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[Pharmacological approach to cerebral cortical development].

Nihon Yakurigaku Zasshi 2019 ;153(4):167-171

Laboratory of Molecular Life Science, Institute of Biomedical Research and Innovation.

In the developing mammalian cerebral cortex, newly generated neurons migrate toward the pial surface to form a mammalian-specific six-layered cerebral cortex. Genetic studies of human neurological diseases have suggested the involvement of several molecules in cortical neuronal migration. In vivo electroporation is another powerful tool for understanding the molecular mechanisms of neuronal migration. Read More

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http://dx.doi.org/10.1254/fpj.153.167DOI Listing
January 2019

[Analysis of mental states based on peripheral organ activity].

Nihon Yakurigaku Zasshi 2019 ;153(4):161-166

Laboratory for Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo.

Behavioral tests using rodents are widely used for assessing mental states of animals and the effects of pharmacological drugs on psychiatric disorders. However, the results of behavioral tests are sometimes inconsistent due to individual differences. To evaluate animal's mental states based on internal organ activity, we recently developed a new electrophysiological method to simultaneously monitor cortical local field potentials, electrocardiograms, electromyograms, respiratory signals, and vagus nerve spikes in a freely moving rodent. Read More

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http://dx.doi.org/10.1254/fpj.153.161DOI Listing
January 2019

[Neuronal cell death induced by the disruption of endoplasmic reticulum-mediated Ca signaling].

Authors:
Yohei Okubo

Nihon Yakurigaku Zasshi 2019 ;153(4):155-160

Department of Pharmacology, Graduate School of Medicine, The University of Tokyo.

For the function and survival of neurons in the central nervous system, it is indispensable that the intracellular Ca dynamics are properly controlled. The endoplasmic reticulum (ER), a major intracellular Ca store, plays an important role in the control of the intracellular Ca dynamics in neurons through the supply and uptake of Ca. It has been suggested that the disruption of ER Ca signaling is involved in neuronal cell death in various pathological conditions. Read More

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https://www.jstage.jst.go.jp/article/fpj/153/4/153_155/_arti
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http://dx.doi.org/10.1254/fpj.153.155DOI Listing
January 2019
1 Read

[The mechanisms of taxodione-induced apoptosis in BCR-ABL-positive leukemia cells].

Nihon Yakurigaku Zasshi 2019 ;153(4):147-154

Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University.

Chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) are caused by a fusion protein, BCR-ABL, which induces cellular transformation by activating the signaling molecules, STAT5 and Akt. The specific BCR-ABL inhibitors including imatinib, nilotinib, and dasatinib, are clinically utilized in the treatment with CML and ALL patients. Although these BCR-ABL inhibitors are initially successful in the treatment of leukemia, many patients develop drug resistance due to the appearance of the gatekeeper mutation of BCR-ABL, T315I. Read More

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http://dx.doi.org/10.1254/fpj.153.147DOI Listing
January 2019
1 Read

[About the certification system of pharmacology educators].

Authors:
Yuji Ikegaya

Nihon Yakurigaku Zasshi 2019;153(3):99-102

Graduate School of Pharmaceutical Sciences, The University of Tokyo.

In 2019, the Japanese Pharmacological Society launches a certification system of pharmacology educators. Many members of this society are now involved in student education as well as researches in clinical and basic science. We need talented teachers with excellent educational ability so that current and future students can receive high standards of pharmacology education. Read More

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http://dx.doi.org/10.1254/fpj.153.99DOI Listing
January 2019
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[Pharmacological characteristics and clinical study results of ileal bile acid transporter inhibitor elobixibat (GOOFICE tablet 5 mg)].

Nihon Yakurigaku Zasshi 2019;153(3):129-138

Clinical Development Department, EA Pharma Co., Ltd.

Elobixibat is a novel small-molecule that acts as an inhibitor of the ileal bile acid transporter (IBAT), and used for chronic constipation in Japan. Elobixibat selectively inhibited IBAT in vitro, and dose-dependently inhibited the absorption of bile acids in vivo. Also, elobixibat dose-dependently increased wet fecal weight in a rat loperamide-induced constipation model. Read More

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http://dx.doi.org/10.1254/fpj.153.129DOI Listing
January 2019
3 Reads

[Estimation of mechanism-of-action of pharmaceutical compounds based on quantitative systems pharmacology].

Authors:
Ryuta Saito

Nihon Yakurigaku Zasshi 2019;153(3):124-128

Discovery Technology Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation.

To accelerate drug discovery and development, improve R&D efficiency and facilitate scientific decision making, quantitative systems pharmacology (QSP) is increasingly being utilized in the pharmaceutical and biotech industry. QSP approach has emerged as a central technology in innovative framework based on "learn and confirm" cycle, which is currently called as model-informed drug discovery and development (MID3). QSP approach is supporting the rational decision in drug discovery and development from exploratory research to late-stage clinical development, and enables selection/validation of novel target molecules, identification of mechanism-of-action of pharmacological/toxicological compounds, prioritization of pharmaceutical candidates, facilitating translational research, optimization of clinical trials, and others. Read More

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http://dx.doi.org/10.1254/fpj.153.124DOI Listing
January 2019

[Current situation of researches on a sensor organelle, primary cilium, to understand the pathogenesis of ciliopathy].

Nihon Yakurigaku Zasshi 2019;153(3):117-123

Department of Molecular Pharmacology, Tohoku University School of Medicine.

Primary cilium is a membrane-protruding immotile sensory organelle. It had been supposed that the cilium was a static organelle for long periods. However, recent studies have uncovered that the cilium is dynamically organized organelle in a cell cycle-dependent manner; it is formed during G/G phase and resorbed when the cells enter cell division cycle. Read More

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http://dx.doi.org/10.1254/fpj.153.117DOI Listing
January 2019

[Pharmacotherapy from the viewpoint of nursing: pharmacology education for nurses as a practitioner of medication].

Nihon Yakurigaku Zasshi 2019;153(3):111-116

Department of Clinical Pharmacology, School of Nursing, Faculty of Medicine, University of Miyazaki.

The installation of nursing colleges/universities has rapidly increased from the late 1990s, there are 263 institutions in Japan as of 2018. Pharmacology and clinical pharmacology education in undergraduate and postgraduate nursing colleges/universities is highly important, in addition, the education of clinical pharmacology in the training courses of Certified Nurse Specialist, Certified Nurse and Nurse designated procedures is positioned as compulsory subject. Whereas, the lack of human resources involved in pharmacology education due to the rapid increase of nursing colleges/universities cannot be denied. Read More

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http://dx.doi.org/10.1254/fpj.153.111DOI Listing
January 2019

[Current situation and problems of pharmacology education in the Faculty of Pharmaceutical Sciences].

Authors:
Toshiaki Kume

Nihon Yakurigaku Zasshi 2019;153(3):107-110

Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama.

About 12 years ago, a 6-year course was started in the Faculty of Pharmacy, and now more than 90% of the students enrolled in the school of Pharmacy belong to the 6-year course. However, as the new educational system progresses, some issues have been pointed out, and it is necessary to proceed with the correction in the future. As the environment surrounding pharmaceutical education changes, it is necessary for the pharmacology education to evolve in accordance with the trend. Read More

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http://dx.doi.org/10.1254/fpj.153.107DOI Listing
January 2019
1 Read

[Historical background of pharmacology education in medical school in Japan].

Authors:
Yoshio Goshima

Nihon Yakurigaku Zasshi 2019;153(3):103-106

Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine.

Medicine is the science and practice of the diagnosis, treatment, and prevention of a various kind of mental and physical disorders. About 150 year ago, Japan was opened to an influx of foreigners and foreign influence that went far beyond anything the Japanese had imagined. Meiji government decided to adopt German medicine in 1869. Read More

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https://www.jstage.jst.go.jp/article/fpj/153/3/153_103/_arti
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http://dx.doi.org/10.1254/fpj.153.103DOI Listing
January 2019
6 Reads

[Drug properties of fosravuconazole L-lysine ethanolate (NAILIN Capsules 100 mg), a new oral azole therapeutic for onychomycosis: an analysis based on non-clinical and clinical trial data].

Nihon Yakurigaku Zasshi 2019;153(2):79-87

Teikyo University Institute of Medical Mycology.

Ravuconazole is a fourth generation azole exerting strong antifungal activity, with low drug-drug interaction and hepatic dysfunction risks. Fosravuconazole l-lysine ethanolate (fosravuconazole; NAILIN Capsules 100 mg) was developed as a ravuconazole prodrug. Ravuconazole exerts strong antifungal activity against various pathogenic fungi including dermatophytes and Candida. Read More

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http://dx.doi.org/10.1254/fpj.153.79DOI Listing
January 2019
2 Reads

[Personalized medicine for oral molecular-targeted anticancer drugs].

Authors:
Masatomo Miura

Nihon Yakurigaku Zasshi 2019;153(2):73-78

Department of Pharmacy, Akita University Hospital.

Therapeutic drug monitoring (TDM) is carried out by evaluating drug plasma (or serum) concentrations in response to individual optimal treatments by dose adjustment to improve efficacy or avoid side effects. Many molecular-targeted anticancer drugs show exposure-efficacy and exposure-toxicity relationships. Therefore, plasma concentrations of anticancer drugs can be used as biomarkers. Read More

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http://dx.doi.org/10.1254/fpj.153.73DOI Listing
January 2019
1 Read

[Molecular understanding of hierarchy and lineage of mesenchymal stem cells in vivo].

Nihon Yakurigaku Zasshi 2019;153(2):67-72

Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Mesenchymal stem cell (MSC) is a type of tissue stem cell. In clinical studies, cultured MSCs have shown important therapeutic effects on diseases via the reduction of neurological defects and regulation of immune responses. However, in vivo MSC localization, function, and properties are poorly understood; therefore, the molecular understanding of MSCs hierarchy is less advanced compared to hematopoietic stem cell hierarchy. Read More

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http://dx.doi.org/10.1254/fpj.153.67DOI Listing
January 2019
1 Read

[Dissecting early development of the kidney by single cell transcriptomics].

Nihon Yakurigaku Zasshi 2019;153(2):61-66

Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University.

Each of the billions of the cells in our body exhibits their identity with unique gene expression profile. Recent advances in single cell transcriptomics enable to conduct cell taxonomy identifying new cell types and to re-arrange cells in order of pseudo-time course describing differentiation status of each cell. Even though the cost is still high, the single cell transcriptomics now becomes one of the conventional assays. Read More

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http://dx.doi.org/10.1254/fpj.153.61DOI Listing
January 2019

[Hypoxia epigenetically bestows astrocytic differentiation potential on human pluripotent cell-derived neural stem/precursor cells].

Nihon Yakurigaku Zasshi 2019;153(2):54-60

Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University.

The central nervous system (CNS) is composed of three major cell types, neurons, astrocytes, and oligodendrocytes, which differentiate from common multipotent neural stem/precursor cells (NS/PCs). However, NS/PCs do not have this multipotentiality from the beginning: neurons are generated first and astrocytes are later during CNS development. This developmental progression is observed in vitro by using human (h) NS/PCs derived from pluripotent cells, such as embryonic- and induced pluripotent-stem cells (ES/iPSCs), however, in contrast to rodent's pluripotent cells, they require quite long time to obtain astrocytic differentiation potential. Read More

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http://dx.doi.org/10.1254/fpj.153.54DOI Listing
January 2019
1 Read

[MPMBP, a novel bisphosphonate with an antioxidant side chain, stimulates bone formation through inhibition of NF-κB nuclear translocation].

Nihon Yakurigaku Zasshi 2019;153(1):4-10

Center for Environmental Dentistry, Graduate School of Dentistry, Tohoku University.

Bisphosphonates (BPs) are chemically characterized by a P-C-P bond with two lateral side chains on the carbon atom, and have been widely used as anti-resorptive agents in various metabolic bone diseases. 4-[(methylthio) phenylthio] methanebisphosphonate (MPMBP) is a novel non-nitrogen-containing BP with an antioxidant side chain that possesses anti-inflammatory properties. Since inflammation is known to be a cause of the pathological bone resorption, we investigated the effects of MPMBP on bone metabolism both in vitro and in vivo. Read More

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http://dx.doi.org/10.1254/fpj.153.4DOI Listing
January 2019
1 Read

[Pharmacological profiles and clinical effects of amenamevir tablet as treatments for herpes zoster].

Nihon Yakurigaku Zasshi 2019;153(1):35-43

Medical Affairs Department, Maruho Co., Ltd.

Herpes zoster is a viral infectious disease caused by reactivation of varicella zoster virus (VZV) in a latently infected ganglion, and is characterized by blistering and pain developing in a zonal region innervated from the ganglion. Amenamevir is an antiherpes agent that does not have a nucleic acid-like structure, and exerts antiviral action by inhibiting the enzymatic activity of a virus-derived helicase-primase complex, which is considered essential for viral DNA replication. Amenamevir is mainly metabolized by CYP3A, and excreted into feces. Read More

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http://dx.doi.org/10.1254/fpj.153.35DOI Listing
January 2019
1 Read

[Translational behavioral research using common marmosets in the psychiatric field].

Nihon Yakurigaku Zasshi 2019;153(1):28-34

Higher Brain Function Research, Drug Research Division, Sumitomo Dainippon Pharma Co., Ltd.

The drug discovery activities for novel compounds with the superior efficacies to current drugs have been largely unsuccessful in the psychiatric field. One of the main reasons is the lack of appropriate behavioral assays and animal models for psychiatric disorders. Since the prefrontal cortex has great roles in their pathophysiology, non-human primate common marmosets with the well-developed prefrontal cortex would be useful as experimental animals in the future translational research. Read More

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http://dx.doi.org/10.1254/fpj.153.28DOI Listing
January 2019
3 Reads

[Current situation and future issues of antiresorptive agent-related osteonecrosis of the jaw].

Nihon Yakurigaku Zasshi 2019;153(1):22-27

Department of Dentistry and Oral Surgery, Hyogo College of Medicine.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ), which is characterized by refractory bone exposure, has recently emerged as a serious side effect of bisphosphonate (BP) treatment. BRONJ was first thought to be due to administration of high doses of intravenous BP to treat metastatic bone lesions or multiple myeloma. However, more recent studies have indicated that BRONJ also frequently occurs in patients receiving low doses of BP for the treatment of osteoporosis. Read More

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http://dx.doi.org/10.1254/fpj.153.22DOI Listing
January 2019
1 Read

[Anabolic action of teriparatide to osteoporotic patients].

Nihon Yakurigaku Zasshi 2019;153(1):16-21

Developmental Biology of Hard Tissue, Faculty of Dental Medicine, Hokkaido University.

Intermittent administration of human parathyroid hormone (PTH) [1-34], or teriparatide, has been used for osteoporotic treatment, which is available for daily and weekly administration for the osteoporotic patients in Japan, increasing bone mass and reduce bone fracture risk. In general, continuous PTH infusion shows catabolic effects in bone, while the intermittent administration of PTH results in anabolic action in osteoporotic patients. Intermittent PTH administration promotes preosteoblastic proliferation, as well as stimulates osteoblastic bone formation dependent on cell coupling with osteoclasts. Read More

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http://dx.doi.org/10.1254/fpj.153.16DOI Listing
January 2019

[The mechanism of anti-RANKL antibody in the treatment of metabolic bone diseases including osteoporosis - possible applications of anti-RANKL antibody to the treatment of cancer patients].

Authors:
Hisataka Yasuda

Nihon Yakurigaku Zasshi 2019;153(1):11-15

Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd.

Discovery of RANKL (receptor activator of NF-κB ligand) gave a great impact on identification of the mechanisms regulating osteoclast differentiation and function, establishment of research field bridging bone and mineral research and immunology (osteoimmunology), and development of a fully human anti-RANKL monoclonal neutralizing antibody (denosumab). Denosumab has been clinically available for treatment of osteoporosis and cancer-induced bone diseases in the US, Europe and many countries including Japan. Denosumab is a so-called blockbuster of which sales amount was 3. Read More

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http://dx.doi.org/10.1254/fpj.153.11DOI Listing
January 2019
1 Read

[The 139th Regional Meeting (Kanto Area)].

Authors:

Nihon Yakurigaku Zasshi 2019;153(Supplement):S56-S88

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http://dx.doi.org/10.1254/fpj.153.S56DOI Listing
January 2019

[The 69th Regional Meeting (Kita Area)].

Authors:

Nihon Yakurigaku Zasshi 2019;153(Supplement):S1-S55

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http://dx.doi.org/10.1254/fpj.153.S1DOI Listing
January 2019

[Pharmacological profile and clinical findings of palbociclib (IBRANCE capsule 25 mg/125 mg)].

Nihon Yakurigaku Zasshi 2018;152(6):306-318

Medical Affairs Oncology, Pfizer Japan Inc.

Palbociclib is the world's first cyclin dependent kinase (CDK) 4 and 6 inhibitor. It's believed that palbociclib stops the cell cycle progression by inhibiting the activity of the complex consisting of CDK 4/6 and cyclin D, and suppresses tumor growth. In preclinical study using nonclinical model, it was confirmed that most of the cell lines sensitive to palbociclib are estrogen receptor (ER) positive. Read More

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http://dx.doi.org/10.1254/fpj.152.306DOI Listing
January 2018
2 Reads

[Dysfunction of Na/Ca exchangers is associated with cognitive decline in Alzheimer's disease].

Nihon Yakurigaku Zasshi 2018;152(6):299-305

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University.

Na/Ca exchanger (NCX) is mainly expressed in the plasma membrane and mediates electrogenical exchange of one Ca for three Na, depending on the electrochemical gradients across the plasma membrane. NCX has three different isoforms (NCX1, NCX2, NCX3) encoded by distinct genes in mammals. Here, we report that NCX2 and NCX3 protein levels are relatively reduced in hippocampal CA1 of Alzheimer's disease model mice. Read More

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http://dx.doi.org/10.1254/fpj.152.299DOI Listing
January 2018
10 Reads

[Homeostatic regulation of basal ganglia circuit for flexible behavior].

Authors:
Takatoshi Hikida

Nihon Yakurigaku Zasshi 2018;152(6):295-298

Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University.

Behavioral inflexibility has been reported in various psychiatric disorders including drug addiction and schizophrenia. Considerable evidence has demonstrated a critical role for the basal ganglia in the flexibility of behavioral strategies. These processes are guided by the activity of two discrete neuron types, dopamine D1- or D2-receptor expressing medium spiny neurons (D1-/D2-MSNs) in the basal ganglia circuit. Read More

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https://www.jstage.jst.go.jp/article/fpj/152/6/152_295/_arti
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http://dx.doi.org/10.1254/fpj.152.295DOI Listing
January 2018
14 Reads

[Consideration for future in vitro BBB models - technical development to investigate the drug delivery to the CNS].

Authors:
Kaoru Sato

Nihon Yakurigaku Zasshi 2018;152(6):287-294

National Institute of Health Sciences.

Blood vessels in the central nervous system (CNS) limit the material exchange between blood and parenchyma by blood brain barrier (BBB). At present, no appropriate in vitro BBB models are available for the investigation whether or not the candidate compounds for new drugs could be delivered to the CNS. This causes huge difficulties of the development of CNS drugs and prediction of CNS adverse effects. Read More

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http://dx.doi.org/10.1254/fpj.152.287DOI Listing
January 2018

[DEPDC5, a new key to understand various epilepsies].

Authors:
Saeko Ishida

Nihon Yakurigaku Zasshi 2018;152(6):281-285

Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU).

Epilepsy is one of the most frequent neurological disorders characterized by spontaneous and recurrent seizures. Most seizures last for the lifetime and the patients require long term therapies. However, about 30% of the patients are refractory to antiepileptic drugs. Read More

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http://dx.doi.org/10.1254/fpj.152.281DOI Listing
January 2018
1 Read

[Function of synaptic vesicle protein 2A (SV2A) as a novel therapeutic target for epilepsy].

Nihon Yakurigaku Zasshi 2018;152(6):275-280

Department of Pharmacology, Osaka University of Pharmaceutical Sciences.

Epilepsy is a chronic neurologic disease characterized by recurrent seizures, affecting nearly 1% of the population. Synaptic vesicle protein 2A (SV2A) is a membrane protein specifically expressed in synaptic vesicles and is now implicated in the pathogenesis of epileptic disorders. This is because 1) Sv2a-knockout mice exhibit severe seizures, 2) SV2A serves as a specific binding site for certain antiepileptics (e. Read More

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https://www.jstage.jst.go.jp/article/fpj/152/6/152_275/_arti
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http://dx.doi.org/10.1254/fpj.152.275DOI Listing
January 2018
2 Reads

[Epileptogenesis mediated by glial cells].

Nihon Yakurigaku Zasshi 2018;152(6):268-274

Department of Pediatrics, Interdisciplinary Graduate School of Medicine, University of Yamanashi.

Epilepsy is one of the most common diseases of the central nervous system. Many epilepsies are controllable because of the existence of different antiepileptic drugs with multiple mechanisms of action. However, about 30% of epilepsy is so-called refractory epilepsy in which existing drugs do not show enough therapeutic effects. Read More

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http://dx.doi.org/10.1254/fpj.152.268DOI Listing
January 2018

[Regulation of adventitial fibroblast functions in pulmonary hypertension].

Authors:
Muneyoshi Okada

Nihon Yakurigaku Zasshi 2018 ;152(5):258

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http://dx.doi.org/10.1254/fpj.152.258DOI Listing
January 2018

[Current situation of diagnosis for food allergy].

Nihon Yakurigaku Zasshi 2018 ;152(5):256-257

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http://dx.doi.org/10.1254/fpj.152.256DOI Listing
January 2018
1 Read

[Pharmacological profile and clinical efficacy of transdermal patch containing emedastine difumarate (ALLESAGA TAPE)].

Nihon Yakurigaku Zasshi 2018 ;152(5):246-255

Research and Development Division, Hisamitsu Pharmaceutical Co., Inc.

ALLESAGA TAPE is the first transdermal drug delivery system of emedastine difumarate, as a second-generation antihistamine, for allergic rhinitis. It has been suggested that the efficacy of emedastine difumarate in allergic rhinitis is mediated through a combination of chemical mediator release inhibitory effects and eosinophil chemotaxis inhibitory effects, in addition to a strong anti-histaminic effect. In the pharmacological evaluation on histamine-induced vascular hyperpermeability in rats, ALLESAGA TAPE showed an anti-histaminic effect in a dose-dependent manner and exhibited a long-lasting anti-histaminic effect until 24 hours after administration. Read More

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https://www.jstage.jst.go.jp/article/fpj/152/5/152_246/_arti
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http://dx.doi.org/10.1254/fpj.152.246DOI Listing
January 2018
14 Reads

[Establishment of a novel evaluation system for dopaminergic axonal outgrowth and its regulatory factor].

Authors:
Yasuhiko Izumi

Nihon Yakurigaku Zasshi 2018 ;152(5):240-245

Laboratory of Pharmacology, Kobe Pharmaceutical University.

The nigrostriatal dopaminergic pathway is implicated with Parkinson's disease. Elucidation of this projection mechanism is not only important for considering developmental brain formation, but also contributes to the development of a therapy for regenerating the lost neural circuit. Although several axon guidance cues have been reported to induce dopaminergic axons from the substantia nigra to the striatum, the mechanisms by which the dopaminergic axons extend in the striatum remain unclear. Read More

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https://www.jstage.jst.go.jp/article/fpj/152/5/152_240/_arti
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http://dx.doi.org/10.1254/fpj.152.240DOI Listing
January 2018
12 Reads

[Pathophysiological functions of gas mediators in neurodegeneration].

Authors:
Yoshinori Mikami

Nihon Yakurigaku Zasshi 2018 ;152(5):233-239

Department of Physiology, Faculty of Medicine, Toho University.

Since the discovery of nitric oxide (NO) as gaseous signaling molecule, two other gaseous mediators, carbon monoxide (CO) and hydrogen sulfide (HS) have been found to be also involved in many physiological and pathophysiological functions. This review will briefly summarize our recent progress in the pathophysiology of NO and HS. In the photoreceptor cells, the level of intracellular Ca is kept relatively low by HS. Read More

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https://www.jstage.jst.go.jp/article/fpj/152/5/152_233/_arti
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http://dx.doi.org/10.1254/fpj.152.233DOI Listing
January 2018
17 Reads

[Physiological roles of redox signals in relation to synaptic plasticity and brain functions].

Authors:
Sho Kakizawa

Nihon Yakurigaku Zasshi 2018 ;152(5):227-232

Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University.

In our classical knowledge, redox molecules, including reactive oxygen species (ROS), nitric oxide (NO) and hydrogen sulfide, are considered to be generated as byproducts of aerobic metabolism and act as harmful oxidants of macromolecules, such as proteins and lipids. On the other hands, recently, expressions of enzymes producing redox molecules are identified and reported to be expressed in wide range of tissues, including brain. Moreover, activities of some of these enzymes are revealed to be regulated by physiological signals (e. Read More

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http://dx.doi.org/10.1254/fpj.152.227DOI Listing
January 2018

[Development and application of a novel thiol labeling reagent for protein thiol analysis].

Authors:
Yuki Tatenaka

Nihon Yakurigaku Zasshi 2018 ;152(5):223-226

Dojindo Laboratories.

Modification of protein thiol is one of the most important post-translational modifications and it occurs depending on the redox state in cells. Protein S-nitrosylation is NO (nitric oxide)-dependent modification of protein thiols and is crucial for regulation of cellular functions such as transcription, protein expression, and signal transduction. Maleimide reagents are generally used to assess the redox status of the thiols in a protein of interest. Read More

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http://dx.doi.org/10.1254/fpj.152.223DOI Listing
January 2018

[Production of HS, HS, and persulfide species (CysSSH and GSSH) by 3-mercaptopyruvate sulfurtransferase].

Authors:
Norihiro Shibuya

Nihon Yakurigaku Zasshi 2018 ;152(5):216-222

National Institute of Neuroscience, National Center of Neurology and Psychiatry.

Accumulating evidence shows that hydrogen sulfide (HS) has physiological roles in various tissues and organs, including the regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney, and brain from ischemic insult. HS is produced from l-cysteine by pyridoxal 5'-phosphate (PLP)-dependent enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). 3-Mercaptopyruvate sulfurtransferase (3MST) is the third HS-producing enzyme, and its substrate 3-mercaptopyruvate (3MP) is provided from l-cysteine and α-ketoglutarate (α-KG) by a PLP-dependent cysteine aminotransferase (CAT). Read More

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https://www.jstage.jst.go.jp/article/fpj/152/5/152_216/_arti
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http://dx.doi.org/10.1254/fpj.152.216DOI Listing
January 2018
11 Reads

[Anti-inflammatory action of the transcription factor Nrf2].

Authors:
Yasuhiko Izumi

Nihon Yakurigaku Zasshi 2018 ;152(4):209

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http://dx.doi.org/10.1254/fpj.152.209DOI Listing
January 2018

[Extracellular matrix biomarkers for cardiac diseases].

Authors:
Muneyoshi Okada

Nihon Yakurigaku Zasshi 2018 ;152(4):208

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http://dx.doi.org/10.1254/fpj.152.208DOI Listing
January 2018

[Current progress of research and use of microminipigs in drug development].

Nihon Yakurigaku Zasshi 2018 ;152(4):202-207

Swine and Poultry Department, Shizuoka Prefectural Research Institute of Animal Industry, Swine and Poultry Research Center.

The use of minipigs has been increasing in the areas of pharmacology researches and drug development. The microminipig developed by Fuji Micra Inc. (Shizuoka, Japan) inherits characteristics of other pig strains showing several similarities to humans in anatomy, physiology, omnivorousness and diurnal, but at the same time has several advantages over other pig strains because of its small size which allows easy keeping, handling and dosing, and saving of test substances. Read More

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https://www.jstage.jst.go.jp/article/fpj/152/4/152_202/_arti
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http://dx.doi.org/10.1254/fpj.152.202DOI Listing
January 2018
1 Read