Interdependent and separable functions of MRN-C complex members couple formation and repair of meiotic DSBs.
Proc Natl Acad Sci U S A 2018 Apr 23. Epub 2018 Apr 23.
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305;
Faithful inheritance of genetic information through sexual reproduction relies on the formation of crossovers between homologous chromosomes during meiosis, which, in turn, relies on the formation and repair of numerous double-strand breaks (DSBs). As DSBs pose a potential threat to the genome, mechanisms that ensure timely and error-free DSB repair are crucial for successful meiosis. Here, we identify NBS-1, the ortholog of the NBS1 (mutated in Nijmegen Breakage Syndrome) subunit of the conserved MRE11-RAD50-NBS1/Xrs2 (MRN) complex, as a key mediator of DSB repair via homologous recombination (HR) during meiosis. Read More