171,976 results match your criteria Nihon Shinkei Seishin Yakurigaku Zasshi Japanese Journal of Psychopharmacology[Journal]


Efficacy of novel β -adrenoreceptor agonist vibegron on nocturia in patients with overactive bladder: A post-hoc analysis of a randomized, double-blind, placebo-controlled phase 3 study.

Int J Urol 2018 Dec 17. Epub 2018 Dec 17.

Kyorin Pharmaceutical, Tokyo, Japan.

Objectives: To investigate the efficacy of vibegron on nocturia in patients with overactive bladder.

Methods: Among the Japanese overactive bladder patients enrolled in the placebo-controlled, multicenter, randomized, double-blind phase 3 study of vibegron, a total of 669 patients with nocturia (≥1 nocturnal void) were included. Changes from baseline in micturition parameters were compared for vibegron treatment (50 and 100 mg/day) versus placebo. Read More

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December 2018

CUTICULAR DRUSEN: Risk of Geographic Atrophy and Macular Neovascularization.

Retina 2018 Dec 14. Epub 2018 Dec 14.

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York.

Purpose: Cuticular drusen (CD) have been associated with manifestations of age-related macular degeneration such as atrophy and neovascularization in the macula. In this study, eyes with CD were followed and investigated for the estimated 5-year risk of progression to sequelae of age-related macular degeneration such as geographic atrophy (GA) and macular neovascularization (MNV).

Methods: A consecutive series of patients with CD were followed for the development of GA and MNV. Read More

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December 2018
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Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions.

Org Biomol Chem 2018 Dec 17. Epub 2018 Dec 17.

Department of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.

Use of the ku70-deficient strain of Coprinopsis cinerea enabled confirmation within the native context of the central role the sesquiterpene synthase Cop6 plays in lagopodin biosynthesis. Furthermore, yeast in vivo bioconversion and in vitro assays of two cytochrome P450 monooxygenases Cox1 and Cox2 allowed elucidation of the network of oxidation steps that build structural complexity onto the α-cuprenene framework during the biosynthesis of lagopodins. Three new compounds were identified as intermediates formed by the redox enzymes. Read More

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December 2018

A new method for tensioning of a chronic tibial bony avulsion of the posterior cruciate ligament as a posteromedial bundle and augmentation by anterolateral bundle reconstruction in a bicruciate ligament injury: A case report.

Asia Pac J Sports Med Arthrosc Rehabil Technol 2019 Jan 22;15:13-16. Epub 2018 Nov 22.

Department of Sports Medicine, Kameda Medical Center, Chiba, Japan.

Multiple ligament injury is associated with high instability; hence, it is necessary to restore stability through application of a reliable treatment strategy. We report our experiences in handling a case of ruptured anterior cruciate ligament (ACL) complicated by chronic bony avulsion of the posterior cruciate ligament (PCL). Favourable results were obtained as a result of ACR reconstruction following a new method for tensioning of the chronic tibial bony avulsion of PCL as a postero-medial bundle and augmentation by PCL anterolateral bundle reconstruction. Read More

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January 2019

Effect of epicardial fat and metabolic syndrome on reverse atrial remodeling after ablation for atrial fibrillation.

J Arrhythm 2018 Dec 13;34(6):607-616. Epub 2018 Oct 13.

Division of Cardiology Department of Medicine Nihon University School of Medicine Tokyo Japan.

Background: Metabolic syndrome/epicardial adipose tissue (EAT) plays an important role in atrial fibrillation (AF). Although reverse atrial remodeling (RAR) often occurs after AF ablation, the effects of EAT on RAR remain unknown.

Methods: Study subjects were 104 patients in whom transthoracic echocardiography (TTE) was performed before AF ablation and 3, 6, and 12 months afterward. Read More

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December 2018

Recurrence Patterns and Outcomes of Salvage Surgery in Cases of Non-Curative Endoscopic Submucosal Dissection without Additional Radical Surgery for Early Gastric Cancer.

Digestion 2018 Dec 14;99(1):52-58. Epub 2018 Dec 14.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: The outcomes of salvage surgery for recurrence after non-curative endoscopic submucosal dissection (ESD) without additional radical surgery for early gastric cancer (EGC) remain unclear. We determined the recurrence patterns and outcomes of salvage surgery in such cases using data from a multicenter, retrospective study.

Methods: Of 15,785 patients who underwent ESD for EGC at 19 participating institutions between January 2000 and August 2011, 1,969 failed to meet the current curative criteria after ESD. Read More

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December 2018
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Menthol-induced facilitation of cerebrocortical excitatory propagation induced by air puff stimulation of the nasal cavity in the rat: An optical imaging study.

Neurosci Lett 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Molecular Dynamics Imaging Unit, RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

Temperature plays a critical role in the sensation of airflow in the nasal mucosa. Neural activities of the ethmoidal nerve, a trigeminal afferent, responding to airflow are suppressed by warm airflow, whereas cold airflow enhances the ethmoidal nerve activities, which is mimicked by application of menthol, a cold-sensitive TRPM8 receptor agonist. However, it has been an open issue how menthol modulates the spatiotemporal profiles of neural activities of somatosensory cortical neurons. Read More

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December 2018

Long-term safety and efficacy of antimuscarinic add-on therapy in patients with overactive bladder who had a suboptimal response to mirabegron monotherapy: A multicenter, randomized study in Japan (MILAI II study).

Int J Urol 2018 Dec 13. Epub 2018 Dec 13.

Astellas Pharma Inc., Tokyo, Japan.

Objectives: To evaluate the long-term safety (primary objective) and efficacy (secondary objective) of antimuscarinic add-on therapy in patients receiving mirabegron.

Methods: During a 2-week screening period, patients (aged ≥20 years, mirabegron treatment for ≥6 weeks, residual overactive bladder symptoms) received mirabegron 50 mg once daily. These patients were subsequently randomized to 52 weeks' treatment with mirabegron 50 mg/day plus an antimuscarinic (solifenacin 5 mg, propiverine 20 mg, imidafenacin 0. Read More

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December 2018
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Association of circulating microRNA-122 and microRNA-29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Chronic hepatitis (CH) in dogs is common and has the tendency to progress to liver cirrhosis (LC). Circulating microRNAs might have the potential as markers for disease progression.

Objectives: To investigate whether concentration of specific microRNAs in serum correlate with the stage and grade of CH in Labrador Retrievers. Read More

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December 2018
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The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Chuo-ku, Tokyo 103-0002, Japan.

Recent clinical studies have demonstrated the protective effect of xanthine oxidase (XO) inhibitors against chronic kidney diseases, although the underlying molecular mechanisms remain unclear. However, to date, neither clinical nor basic research has been carried out to elucidate the efficacy of XO inhibitor administration for IgA nephropathy. We thus investigated whether febuxostat, an XO inhibitor, exerts a protective effect against the development of IgA nephropathy, using gddY mice as an IgA nephropathy rodent model. Read More

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December 2018
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Multiple Exon Skipping in the Duchenne Muscular Dystrophy Hot Spots: Prospects and Challenges.

J Pers Med 2018 Dec 7;8(4). Epub 2018 Dec 7.

Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G2H7, Canada.

Duchenne muscular dystrophy (DMD), a fatal X-linked recessive disorder, is caused mostly by frame-disrupting, out-of-frame deletions in the () gene. Antisense oligonucleotide-mediated exon skipping is a promising therapy for DMD. Exon skipping aims to convert out-of-frame mRNA to in-frame mRNA and induce the production of internally-deleted dystrophin as seen in the less severe Becker muscular dystrophy. Read More

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December 2018

[Index].

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):Index4

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January 2018

[Table of Contents].

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):Contents4

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January 2018

[Notice].

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):Announce4

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January 2018

[Information].

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):734-760

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January 2018

[Proceedings of Regional Meeting of the Japan Geriatrics Society].

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):698-733

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January 2018

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):696-697

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January 2018

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):695

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):694

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January 2018

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):691-693

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January 2018

[The theory of theatrical care performance for dementia patients].

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):686-690

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January 2018

[An elderly case of squamous cell lung cancer treated continuously with pembrolizumab without any decline in the life function].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):679-685

Department of Respiratory Medicine, Tokyo Metropolitan Geriatric Hospital.

Background: Whether or not immune checkpoint inhibitors are safe and effective for the elderly remains unclear, even though these drugs were approved two years ago for the treatment of advanced non-small cell lung cancer in Japan. Older cancer patients are vulnerable to chemotherapy, so their life function should be closely monitored before starting, continuing, or discontinuing cancer treatment.

Case: An 85-year-old man showed a wedge-shaped shadow in the apical portion of the left lung on chest computed tomography. Read More

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January 2018

[A case of late-onset paraphrenia in a very elderly patient receiving home medical care].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):675-678

Graduate School of Comprehensive Human Science, Faculty of Health and Sports Sciences, University of Tsukuba.

A 94 year old woman with a late-onset paraphrenia was referred to our clinic from a community care center. The patient showed symptoms of paranoia and auditory hallucination. The patient was in conflict with her neighbors regarding noise-related problems and was experiencing loss of appetite. Read More

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January 2018

[Diagnostic significance of computed tomography findings of foreign body in esophagus].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):668-674

Department of Internal Medicine II, Shimane University, Faculty of Medicine.

An 84-year-old male with dysphagia was referred to our hospital. Chest computed tomography (CT) showed a rectangular structure along with artificial air in the cervical esophagus. Endoscopy revealed a 'shogi' game piece in the same region shown in CT findings, which was recovered during the endoscopic procedure. Read More

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January 2018

[Medical team's struggle with financial abuse in the corresponding -Limitation of the adult guardianship system: A case report].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):663-667

Department of Internal Medicine, Nagoya City Kousei-in.

Upon diagnosis of dementia, a 93-year-old woman was unable to manage her finances. Her nephew illegally spent her money, which was considered as financial abuse.The public office forcibly admitted her to our hospital as a legal measure. Read More

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January 2018

[The evaluation of stored feces in elderly patients by ultrasonography: Three case studies].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):657-662

Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo.

Providing defecation care can be challenging because bowel movements cannot be directly observed in home-care settings, and the objective evaluation of constipation symptoms is difficult, particularly for elderly patients with cognitive impairment. We evaluated the use of rectal ultrasonography (US) to assess the properties and volume of feces in three cases with different fecal properties. Case 1: In a 94-year-old man with normal feces (Bristol stool score: BS type 4), rectal US revealed a crescent-shaped high-echo area without acoustic shadow that was present until the next defecation. Read More

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January 2018

[Association between life space and health literacy in community-dwelling older adults].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):650-656

Department of Community Health Sciences, Kobe University, Graduate School of Health Sciences.

Aim: To examine the association between health literacy (HL) and life space in community-dwelling older adults.

Methods: In this cross-sectional study, we analyzed 210 community-dwelling older adults (mean age: 74.6 years, women: 63. Read More

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January 2018

[The relationship between death from renal insufficiency and diuretic therapy among older adults at two nursing homes catering atomic bomb survivors].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):640-649

Department of Internal Medicine, Ohtagawa Hospital.

Aim: In Geriatrics Gerontology International we previously reported the efficacy of reducing diuretics to prevent falls and fractures in older adults. We have since noticed another important problem, regarding the diuretic therapy for older adults with decreased muscle and water volumes. We performed a study on renal insufficiency and diuretic therapy in an attempt to confirm the need for case control study between standard diuretic therapy administered, according to guidelines and "NY-mode" diuretic therapy, which involves the administration of the mineral-corticoid receptor inhibitor spironolactone at 12. Read More

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January 2018

[Recombinant tissue plasminogen activator therapy for acute ischemic stroke in older patients].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):632-639

Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center.

Aim: As the number of aged stroke patients increases in Japan, the proportion of older patients who receive recombinant tissue plasminogen activator (rt-PA, 0.6 mg/kg) is also rising. However, the Japanese stroke guideline indicates that rt-PA therapy must be administered very carefully in older patients (i. Read More

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January 2018

[The isometric knee extension strength threshold for maintaining walking speed and step length in older male inpatients].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):624-631

Department of Rehabilitation Medicine, St Marianna University School of Medicine Yokohama City Seibu Hospital.

Aim: To clarify the minimum knee extension muscle strength needed to maintain walking speed and step length in older male inpatients.

Method: The participants were 786 male inpatients of ≥65 years of age without cerebrovascular disorder, orthopedic disease, malignancy, or dementia. We investigated the participants' isometric knee extension muscle force (kgf/kg), maximum walking speed (m/s) and step length, based on their medical records. Read More

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January 2018

[The associations between readmission within 30 days and the medical institute factors among older patients receiving home medical care].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):612-623

Tokyo Metropolitan Institute of Gerontology.

Aim: To improve preventive strategies for readmission within 30 days after discharge among older patients receiving home medical care services, we examined the associations between readmission within 30 days and the medical institute factors among patients over 75 years of age.

Methods: All patients over 75 years of age receiving home medical care services and who had been admitted to hospital or clinic and discharged between September 2013 and July 2014 in Tokyo, Japan, were participants of this study (n=7,213). The primary outcome was readmission within 30 days after discharge. Read More

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January 2018

[The association of limited health literacy and risk of arterial stiffness in community-dwelling older adults].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):605-611

Department of Liberal arts and Sciences, Toyama Prefectural University.

Aim: This study aimed to investigate the effects of limited health literacy on arterial stiffness measured by the cardio-ankle vascular index (CAVI) in community-dwelling older adults.

Methods: A total of 288 older adults (mean age, 72.4 years, men, n = 99) participated. Read More

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January 2018

[Evaluation of supplemental and oral deglutition foods in bedridden elderly patients receiving parenteral nutrition].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):594-604

Department of Physical Medicine and Rehabilitation, Yokohama City University Medical Faculty.

Background And Aim: We examined oral dyskinesia (OD), wearing artificial tooth, food test findings and conducted a video - fluoroscopic swallowing study (VFSS) in bedridden elderly patients before they were received parenteral nutrition once daily. However, the validity and properties of these deglutition foods have not been evaluated. Therefore, in this study, we clarified four deglutition foods as four aspects. Read More

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January 2018

[Descriptive epidemiology of accelerometer-measured moderate to vigorous physical activity in Japanese older adults].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):584-593

Department of Preventive Medicine and Public Health, Tokyo Medical University.

Aim: Most physical activity (PA) guidelines for health promotion recommend moderate to vigorous PA (MVPA) lasting at least 10 minutes (long-bout MVPA). However, recent studies have shown the beneficial effects of short-bout MVPA (intermittent and lasting <10 minutes). Therefore, we aimed to clarify the detailed patterns of MVPA of community-dwelling older adults using accelerometers. Read More

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January 2018

[Review: biomedical aspect of supercentenarians].

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):578-583

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January 2018

[Brain pathology of centenarians and supercentenarians].

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):562-569

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January 2018

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Nihon Ronen Igakkai Zasshi 2018 ;55(4):553

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January 2018

[Global trends in the prevalence of dementia].

Authors:

Nihon Ronen Igakkai Zasshi 2018 ;55(4):547-552

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January 2018

[Target blood pressure level in older patients with hypertension].

Authors:

Nihon Ronen Igakkai Zasshi 2018 ;55(4):539-546

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January 2018

Authors:

Nihon Ronen Igakkai Zasshi 2018 ;55(4):464-538

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January 2018

Authors:

Nihon Ronen Igakkai Zasshi 2018 ;55(4):463

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January 2018

Authors:

Nihon Ronen Igakkai Zasshi 2018 ;55(4):461-462

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January 2018

A case of incomplete Kawasaki disease with extremely high serum ferritin and interleukin-18 levels.

BMC Pediatr 2018 Dec 12;18(1):386. Epub 2018 Dec 12.

Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi, Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan.

Background: The clinical features and laboratory parameters of patients with Kawasaki disease (KD) and systemic juvenile idiopathic arthritis (sJIA) occasionally overlap. Therefore, serum levels of cytokine and ferritin are used as markers to distinguish between KD and sJIA. KD patients have a high level of interleukin (IL)-6, low level of IL-18, and no elevation of the level of serum ferritin. Read More

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December 2018

A novel, flexible and automated manufacturing facility for cell-based health care products: Tissue Factory.

Regen Ther 2018 Dec 19;9:89-99. Epub 2018 Sep 19.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Introduction: Current production facilities for Cell-Based Health care Products (CBHPs), also referred as Advanced-Therapy Medicinal Products or Regenerative Medicine Products, are still dependent on manual work performed by skilled workers. A more robust, safer and efficient manufacturing system will be necessary to meet the expected expansion of this industrial field in the future. Thus, the 'flexible Modular Platform (fMP)' was newly designed to be a true "factory" utilizing the state-of-the-art technology to replace conventional "laboratory-like" manufacturing methods. Read More

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December 2018

Application of Lactoferrin and 1-Antitrypsin in Gingival Retention Fluid to Diagnosis of Periodontal Disease.

Dis Markers 2018 7;2018:4308291. Epub 2018 Nov 7.

Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan.

Objectives: Periodontal disease is prevalent and has an inflammation associated with not only oral but also systemic pathologies. The diagnosis by biomarkers is required for clinical practice on periodontal disease. The lactoferrin and 1-antitrypsin were both inflammation-related molecules. Read More

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November 2018

Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days.

Environ Health Prev Med 2018 Dec 6;23(1):61. Epub 2018 Dec 6.

Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine, Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.

Background: To develop human space exploration, it is necessary to study the effects of an isolated and confined environment, as well as a microgravity environment, on cerebral circulation. However, no studies on cerebral circulation in an isolated and confined environment have been reported. Therefore, we investigated the effects of a 14-day period of confinement in an isolated environment on dynamic cerebral autoregulation. Read More

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December 2018

APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment?

Hepatol Int 2018 Dec 11. Epub 2018 Dec 11.

Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi, Kofu-shi, Yamanashi, 400-8506, Japan.

Chronic hepatitis C virus (HCV) infection is common among patients with chronic kidney disease (CKD) and those on hemodialysis due to nosocomial infections and past blood transfusions. While a majority of HCV-infected patients with end-stage renal disease are asymptomatic, some may ultimately experience decompensated liver diseases and hepatocellular carcinoma. Administration of a combination of elbasvir/grazoprevir for 12 weeks leads to high sustained virologic response (SVR) rates in patients with HCV genotypes (GTs) 1a, 1b or 4 and stage 4 or 5 CKD. Read More

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December 2018

Evaluation of age-related differences in anterior cruciate ligament size.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: The purpose of this study was to reveal the relation between age and the morphological characteristics of the anterior cruciate ligament (ACL) using magnetic resonance imaging (MRI).

Methods: Thirty-seven young subjects who were diagnosed with a meniscus injury without ACL tear using MRI (15 male and 22 female, median age 26, range 15-49), and 33 elderly subjects for whom knee MRI was performed before uni-compartmental knee arthroplasty (11 male and 22 female, median age 77, range 60-83), were included in this study. In the elderly group, healthy ACL gross morphology was confirmed macroscopically during surgery. Read More

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December 2018