Quantitative magnetic resonance imaging of brain atrophy in a mouse model of Niemann-Pick type C disease.
- John W Totenhagen,
- Adam Bernstein,
- Eriko S Yoshimaru,
- Robert P Erickson,
- Theodore P Trouard
PLoS One 2017 24;12(5):e0178179. Epub 2017 May 24.
Biomedical Engineering Program, University of Arizona, Tucson, Arizona, United States of America.
In vivo magnetic resonance imaging (MRI) was used to investigate regional and global brain atrophy in the neurodegenerative Niemann Pick Type C1 (NPC1) disease mouse model. Imaging experiments were conducted with the most commonly studied mouse model of NPC1 disease at early and late disease states. High-resolution in vivo images were acquired at early and late stages of the disease and analyzed with atlas-based registration to obtain measurements of twenty brain region volumes. Read More