46,439 results match your criteria Nicotine & Tobacco Research[Journal]


Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation.

PLoS One 2019 25;14(4):e0215853. Epub 2019 Apr 25.

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.

The urinary metabolites (Z)-7-[1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid (8-iso-PGF2α), an F2-isoprostane and biomarker of oxidative damage, and "prostaglandin E2 metabolite" (PGE-M), a biomarker of inflammation, are elevated in cigarette smokers. However, there is little information in the literature on the longitudinal stability of these widely used biomarkers. In a large clinical trial involving 10 institutional sites, smokers were given, free of charge over a period of 20 weeks, Spectrum NRC600/601 research cigarettes containing 15. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215853PLOS

The impact of content, frame and social identity on the effectiveness of smoking cessation messages in urban young adults.

J Prev Interv Community 2019 Apr 25:1-14. Epub 2019 Apr 25.

b Department of Psychology , The City College of New York , New York , USA.

The current study examined the impact of health versus economic content, as well as gain versus loss frame, in smoking cessation intervention messages on intention, motivation, and planning to quit smoking. Gender, race, Socioeconomic Status (SES), nicotine dependence, and smoker identity variables were investigated as moderators of the relationship between message content and outcomes. Self-identified smokers were randomly assigned to read a gain or loss framed message with economic or health content. Read More

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http://dx.doi.org/10.1080/10852352.2019.1603677DOI Listing

Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial-mesenchymal transition and invasion in breast cancer cells.

Cell Death Dis 2019 Apr 24;10(5):343. Epub 2019 Apr 24.

School of Life Science & Medicine, Dalian University of Technology, Panjin, China.

Cigarette smoking has been shown to be a carcinogenic factor in breast cancer. Nicotine (Nic), an active component of tobacco, has been found to induce epithelial-mesenchymal transition (EMT) in breast cancer cells. However, the alterations in protein O-GlcNAcylation in Nic-mediated tumorigenesis and malignization mechanisms are less well studied. Read More

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http://dx.doi.org/10.1038/s41419-019-1577-2DOI Listing

Gender differences among cannabis self-cultivators in Spain.

Adicciones 2019 Mar 28;0(0):1142. Epub 2019 Mar 28.

Unidad de Psicología Forense. Universidade de Santiago de Compostela.

The increase in cannabis use coincides with the proliferation of small-scale cannabis cultivation. These crops facilitate substance availability and increased use. Some investigations have studied the characteristics of small-scale cultivators; however, it is not known whether their profiles differ by gender. Read More

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http://dx.doi.org/10.20882/adicciones.1142DOI Listing

Strategies and Design of Hypnosis Intervention for Tobacco Cessation.

Authors:
Mary Herring

Am J Clin Hypn 2019 Apr;61(4):345-369

a Healing Interventions, PC.

The purpose of this article is to share approaches and program design to assist healthcare professionals trained in hypnosis help tobacco users become tobacco free. Helping tobacco users overcome their tobacco dependency is generally seen as challenging to healthcare professionals. Efforts to stop a tobacco habit have components which are both physical and emotional in nature and which produce periods of discomfort and high relapse rates. Read More

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http://dx.doi.org/10.1080/00029157.2018.1491386DOI Listing
April 2019
1 Read

Endotoxin and [Formula: see text] Contamination in Electronic Cigarette Products Sold in the United States.

Environ Health Perspect 2019 Apr;127(4):47008

1 Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston, Massachusetts, USA.

Background: Cigarette smoke contains microbes and microbial toxins, such as endotoxin and [Formula: see text], that may have adverse respiratory effects. To our knowledge, the potential for contamination of electronic cigarette (EC) products sold in the United States has not been investigated.

Objectives: We aimed to determine whether popular cartridge and e-liquid EC products were contaminated with endotoxin or glucan and to examine differences according to the type and flavor of products. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3469
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http://dx.doi.org/10.1289/EHP3469DOI Listing
April 2019
1 Read

Clinical Effectiveness of Traditional and Complementary Medicine Interventions in Combination with Nicotine Replacement Therapy on Smoking Cessation: A Randomized Controlled Pilot Trial.

J Altern Complement Med 2019 Apr 23. Epub 2019 Apr 23.

4 Department of Preventive Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea.

Smoking is associated with many preventable diseases and deaths. Globally, more than 6 million deaths per year are related to smoking. This study aimed to evaluate the pragmatic effectiveness of traditional and complementary medicine (T&CM) interventions for the smoking cessation treatment and to calculate the incremental cost-effectiveness ratio (ICER) of these interventions. Read More

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http://dx.doi.org/10.1089/acm.2019.0009DOI Listing

Strain-specific Altered Nicotine Metabolism in 3,3'-diindolylmethane (DIM) Exposed Mice.

Biopharm Drug Dispos 2019 Apr 24. Epub 2019 Apr 24.

Department of Anesthesiology, Duke University School of Medicine, Durham, NC.

Two indole compounds, indole-3-carbinol (I3C) and its acid condensation product, 3,3'-diindolymethane (DIM), have been shown to suppress expression of flavin-containing monooxygenases (FMO) and induce some hepatic cytochrome P450s (CYPs) in rats. In liver microsomes prepared from rats fed I3C or DIM, FMO-mediated nicotine N-oxygenation was decreased, whereas CYP-mediated nicotine metabolism to nicotine iminium and subsequently to cotinine was unchanged. Therefore, we hypothesized that in mice DIM would also suppress nicotine N-oxygenation without affecting CYP-mediated nicotine metabolism. Read More

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http://dx.doi.org/10.1002/bdd.2182DOI Listing

Co-occurrence of functional modules derived from nicotine-degrading gene clusters confers additive effects in Pseudomonas sp. JY-Q.

Appl Microbiol Biotechnol 2019 Apr 23. Epub 2019 Apr 23.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.

Pseudomonas sp. JY-Q was isolated from nicotine-rich environment and could degrade and tolerate high-content nicotine. Its specific genetic architecture comprised duplicated homologous nicotine-degrading clusters for different functional modules on the whole pathway. Read More

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http://dx.doi.org/10.1007/s00253-019-09800-4DOI Listing

Social Media Mentions of Electronic Nicotine Delivery Systems (ENDS) Battery-Related Overheating, Fires, and Explosions: Findings from a Pilot Study.

Int J Environ Res Public Health 2019 Apr 12;16(8). Epub 2019 Apr 12.

Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.

Serious injuries may result from electronic nicotine delivery systems (ENDS) battery malfunctions, including overheating, fires, and explosions (O/F/E). This pilot study assessed the usefulness of social media monitoring as a tool for gathering information surrounding ENDS battery O/F/E, including changes in the volume and nature of social media mentions over time. Brandwatch, a social media monitoring tool, was queried to examine ENDS battery-related O/F/E over a one-month period, annually, from 2013-2017. Read More

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https://www.mdpi.com/1660-4601/16/8/1308
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http://dx.doi.org/10.3390/ijerph16081308DOI Listing
April 2019
1 Read

Trends in Cigar Use in the United States, 2002 to 2016: Diverging Trends by Race/Ethnicity.

Nicotine Tob Res 2019 Apr 23. Epub 2019 Apr 23.

Institute for Implementation Science in Population Health, The City University of New York, New York, NY USA.

Introduction: While there are racial/ethnic differences in cigarette use, little is known about how non-cigarette tobacco use differs among racial/ethnic groups. The current study investigated trends in cigar use from 2002 to 2016, by racial/ethnic group, in nationally representative United States (US) data.

Methods: Data were drawn from the 2002-2016 National Survey on Drug Use and Health (NSDUH) public use data files (total analytic sample n=630,547 including 54,060 past-month cigar users). Read More

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https://academic.oup.com/ntr/advance-article/doi/10.1093/ntr
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http://dx.doi.org/10.1093/ntr/ntz060DOI Listing
April 2019
1 Read

Selecting and identifying gas-phase protonation isomers of nicotineH using combined laser, ion mobility and mass spectrometry techniques.

Faraday Discuss 2019 Apr 23. Epub 2019 Apr 23.

School of Chemistry, University of Wollongong, Wollongong, Australia.

The detection and assignment of protonation isomers, termed protomers, of gas-phase ions remains a challenge in mass spectrometry. With the emergence of ion-mobility techniques combined with tuneable-laser photodissociation spectroscopy, new experimental combinations are possible to now meet this challenge. In this paper, the differences in fragmentation and electronic spectroscopy of singly protonated (S)-nicotine (nicH+) ions are analysed using action spectroscopy in the ultraviolet region and field asymmetric ion mobility spectrometry (FAIMS). Read More

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http://dx.doi.org/10.1039/c8fd00212fDOI Listing

Interest in Quitting E-Cigarettes among Adults in the United States.

Nicotine Tob Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1093/ntr/ntz062DOI Listing

Quitline program utilization and cessation outcomes: A comparison of provider-referred clients by healthcare settings.

Prev Med Rep 2019 Jun 1;14:100863. Epub 2019 Apr 1.

Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Avenue, Drachman Hall, Tucson AZ-85724, United States of America.

US Public Health Service guidelines recommend that healthcare providers assess patients for tobacco use and refer tobacco users to cessation services (e.g., quitlines). Read More

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http://dx.doi.org/10.1016/j.pmedr.2019.100863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462770PMC

Self-Reported Use of Tobacco, E-cigarettes, and Marijuana Versus Urinary Biomarkers.

Pediatrics 2019 Apr 22. Epub 2019 Apr 22.

Division of Cancer Prevention and Population Sciences, Department of Health Behavior, Roswell Park Comprehensive Center, Buffalo, New York.

Background: Surveys have been instrumental in describing adolescent use of tobacco, electronic cigarettes (e-cigarettes), and marijuana. However, objective biomarker data are lacking. We compared adolescent self-reported use to urinary biomarkers. Read More

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http://dx.doi.org/10.1542/peds.2018-3531DOI Listing

It is time to investigate integrative approaches to enhance treatment outcomes for depression?

Med Hypotheses 2019 May 22;126:82-94. Epub 2019 Mar 22.

School of Psychology and Exercise Science, Murdoch University, Perth, Western Australia 6150, Australia; Clinical Research Australia, 38 Arnisdale Rd, Duncraig, Western Australia 6023, Australia. Electronic address:

Psychological and pharmacological interventions are the most common treatments for adult depression. While these interventions have robust evidence supporting their efficacy, there remain up to 60 percent of individuals who do not respond to treatment, or only partially respond. Unfortunately, efforts at improving outcome rates from new or modified versions of psychological or pharmacological interventions have been disappointing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877193001
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http://dx.doi.org/10.1016/j.mehy.2019.03.008DOI Listing
May 2019
2 Reads

Impaired learning from punishment of errors in smokers: Differences in dorsolateral prefrontal cortex and sensorimotor cortex blood-oxygen-level dependent responses.

Neuroimage Clin 2019 Apr 8;23:101819. Epub 2019 Apr 8.

School of Psychological Sciences, University of Melbourne, 12th floor Redmond Barry Building, Parkville Campus, Melbourne, VIC 3010, Australia. Electronic address:

Cigarette smokers have shown hypersensitivity to reward and hyposensitivity to punishment, along with impairments in learning from errors. The underlying neural mechanism for this failure to adapt performance following an error, particularly when receiving negative feedback, are unclear. Smokers were hypothesized to have poorer error-learning following monetary punishment, associated with hypoactivation in the insula, dorsal anterior cingulate, and hippocampal cortical regions. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101819DOI Listing

Corrigendum to "Concurrent nicotine and tobacco product use among homeless smokers and associations with cigarette dependence and other factors related to quitting" [Drug Alcohol Depend. 185 (2018) 133-140].

Drug Alcohol Depend 2019 Apr 19;199:68. Epub 2019 Apr 19.

Oklahoma Tobacco Research Center, The University of Oklahoma Health Sciences Center, 655 Research Parkway, Suite 400, Oklahoma City, OK, 73104, United States.

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http://dx.doi.org/10.1016/j.drugalcdep.2019.04.002DOI Listing
April 2019
1 Read

Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine.

Neuropharmacology 2019 Apr 19. Epub 2019 Apr 19.

Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA. Electronic address:

Substance use disorders (SUD) are serious public health problems worldwide. Although significant progress has been made in understanding the neurobiology of drug reward and the transition to addiction, effective pharmacotherapies for SUD remain limited and a majority of drug users relapse even after a period of treatment. The United States Food and Drug Administration (FDA) has approved several medications for opioid, nicotine, and alcohol use disorders, whereas none are approved for the treatment of cocaine or other psychostimulant use disorders. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.015DOI Listing
April 2019
7 Reads

Pharmacological Treatment of Youth Substance Use Disorders.

J Child Adolesc Psychopharmacol 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.

While the majority of youth who experiment with alcohol and drugs do not develop problematic levels of use, 5% of adolescents and 15% of young adults meet criteria for a substance use disorder (SUD). Pharmacotherapy, in combination with behavioral interventions, has the potential to increase the likelihood of successful treatment for youth struggling with SUD; however, the literature in this area is limited. To date, there are no Food and Drug Administration (FDA)-approved medications for adolescent SUD, other than buprenorphine, which has been approved down to 16 years of age for opioid use disorder. Read More

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http://dx.doi.org/10.1089/cap.2019.0009DOI Listing

Nicotine Effects on White Matter Microstructure in Young Adults.

Arch Clin Neuropsychol 2019 Jan 7. Epub 2019 Jan 7.

University of Wisconsin-Milwaukee, Department of Psychology, Milwaukee, WI, USA.

Objective: Nicotine use is widely prevalent among youth, and is associated with white matter microstructural changes as measured by diffusion tensor imaging (DTI). In adults, nicotine use is generally associated with lower fractional anisotropy (FA), but in adolescents/young adults (≤30 years), microstructure appears healthier, indicated by higher FA. This cross-sectional study examined associations between nicotine use and white matter microstructure using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in young adults. Read More

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https://academic.oup.com/acn/advance-article/doi/10.1093/arc
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http://dx.doi.org/10.1093/arclin/acy101DOI Listing
January 2019
1 Read

Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats.

Anesthesiology 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.

What We Already Know About This Topic: Opioid-induced respiratory depression results in part from direct activation of μ-opioid receptors expressed in the inspiratory rhythm generator located in the ventrolateral medulla, the preBötzinger ComplexRespiratory neurons within the medulla also express nicotinic acetylcholine receptors, which are made up of five subunits, arranged symmetrically around a central poreActivation of the nicotinic acetylcholine receptor α4, α7, and β2 subunits increases respiratory rhythm, whereas activation of the nicotinic acetylcholine receptor α4β2 or α7 subunits induces analgesia in multiple forms of pain WHAT THIS ARTICLE TELLS US THAT IS NEW: The nonselective nicotinic acetylcholine receptor agonist nicotine and the α4β2 nicotinic acetylcholine receptor agonist A85380, but not the α7 nicotinic acetylcholine receptor agonist PNU282987, reversed respiratory depression induced by activation of μ-opioid receptors in rats both in vitro and in vivoCoadministration of A85380 with fentanyl not only markedly reduced respiratory depression and apneas but also enhanced the fentanyl-induced analgesia BACKGROUND:: Opioid analgesics are widely used for treatment of acute, postoperative, and chronic pain. However, activation of opioid receptors can result in severe respiratory depression. There is an unmet clinical need to develop a pharmacologic therapy to counter opioid-induced respiratory depression without interfering with analgesia. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002676DOI Listing

RNA profile of control and nicotine treated Murine Leydig single cell represented in TPM data.

Data Brief 2019 Jun 27;24:103825. Epub 2019 Mar 27.

School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, PR China.

Data provided in this article is RNA profile represented in RPKM and RPKM based TPM value for the research article titled Nicotine inhibits Murine Leydig cell differentiation and maturation via regulating Hedgehog signal pathway Jiajie et al., 2019. Nicotine treatment changes the RNA profile of Murine Leydig cells. Read More

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http://dx.doi.org/10.1016/j.dib.2019.103825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454091PMC

Prospective study of dual use of e-cigarettes and other tobacco products among school-going youth in rural Appalachian Tennessee.

Ann Thorac Med 2019 Apr-Jun;14(2):127-133

Department of Community and Behavioral Health, East Tennessee State University, Johnson City, TN, USA.

Introduction: E-cigarettes have emerged as the most commonly used tobacco or nicotine products among youth in the United States (US), and usage with other products (dual use) is not well understood. This study assessed dual use and identified associated factors of usage in school-going youth in the high tobacco burdened region of rural Appalachian Tennessee.

Methods: Two waves of data for the same cohort of students were collected in 2014 (Wave 1) and 2016 (Wave 2). Read More

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http://www.thoracicmedicine.org/text.asp?2019/14/2/127/25551
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http://dx.doi.org/10.4103/atm.ATM_217_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467020PMC
April 2019
1 Read

Experiences of women with cervical dysplasia and associated diagnoses using electronic cigarettes for smoking substitution.

Health Expect 2019 Apr 21. Epub 2019 Apr 21.

Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

Introduction: The aim of this qualitative study was to describe the motivation and experiences of women with cervical dysplasia and associated diagnoses who used electronic cigarettes (ECs) to reduce the number of cigarettes they smoked.

Methods: Qualitative interviews were conducted with 26 women aged 18-65 years with cervical dysplasia and associated diagnoses who smoked at least three cigarettes daily for the past year or more and who enrolled in an intervention designed to substitute regular cigarettes with ECs. At the 12-week follow-up, patients were contacted by telephone. Read More

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http://dx.doi.org/10.1111/hex.12897DOI Listing

Telemedicine-delivered treatment interventions for substance use disorders: A systematic review.

J Subst Abuse Treat 2019 Mar 21;101:38-49. Epub 2019 Mar 21.

University of California, San Diego, School of Medicine, Department of Family Medicine and Public Health, 9500 Gilman Drive #0725, La Jolla, CA 92093-0725, United States of America.

With increased negative impacts from opioid and other substance use disorders in the US, it is important for treatments to not only be effective, but also accessible to patients. Treatment delivery via telemedicine, specifically, the use of videoconferencing, which allows real time communication between a patient and a clinician at a distant site, has been shown to be an effective approach for increasing reach and access to treatments for mental health disorders and other chronic illnesses. This systematic review identified and summarized studies examining the effectiveness of telemedicine interventions to deliver treatment for patients with substance use disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07405472183042
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http://dx.doi.org/10.1016/j.jsat.2019.03.007DOI Listing
March 2019
1 Read

Nicotine inhibits rapamycin-induced pain through activating mTORC1/S6K/IRS-1-related feedback inhibition loop.

Brain Res Bull 2019 Apr 18;149:75-85. Epub 2019 Apr 18.

State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Pharmacy, School of Stomatology, Fourth Military Medical University, Xi'an, China. Electronic address:

Mammalian target of rapamycin complex 1 (mTORC1) inhibitors increase the incidence of pain in patients, and this finding has been replicated in animal models. However, reports on possible analgesics for this condition are scant. Accumulating evidence finds that nicotinic acetylcholine receptors (nAChRs) are involved in mediating pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230193020
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.016DOI Listing
April 2019
1 Read

Acupuncture reduces nicotine-induced norepinephrine release in the hypothalamus via the solitary NMDA receptor/NOS pathway.

Neurosci Lett 2019 Apr 17;705:33-38. Epub 2019 Apr 17.

Department of Psychopharmacology, Qiqihar Medical University, Qiqihar, 161006, China; MRC-GHF, College of Korean Medicine, Daegu Haany University, Gyeongsan, 38610, Republic of Korea. Electronic address:

Noradrenergic projections from the nucleus tractus solitarius (NTS) to the hypothalamic paraventricular nucleus (PVN) are involved in nicotine (Nic) dependence. Nic induces hypothalamic norepinephrine (NE) release through N-methyl-d-aspartate receptors (NMDARs) and nitric oxide in the NTS. However, acupuncture attenuates Nic withdrawal-induced anxiety. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193027
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http://dx.doi.org/10.1016/j.neulet.2019.04.036DOI Listing
April 2019
1 Read

Implementing and enforcing a smoke-free policy and by-law on hospital grounds at Central Coast Local Health District.

Health Promot J Austr 2019 Apr 19. Epub 2019 Apr 19.

Central Coast Local Health District, Health Promotion Service, Gosford, NSW, 2250, Australia.

Issue Addressed: Smoking by patients, staff and visitors on the grounds of Central Coast Local Health District (CCLHD).

Methods: NSW Health introduced a smoke-free buildings and vehicles policy in 1988. A smoke-free grounds policy was implemented in 1999, and a smoke-free by-law adopted by CCLHD in 2013, making smoking on CCLHD grounds an offence. Read More

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http://dx.doi.org/10.1002/hpja.255DOI Listing

Uptake of adenine by purine permeases of Coffea canephora.

Biosci Biotechnol Biochem 2019 Apr 18:1-6. Epub 2019 Apr 18.

a Research Institute for Sustainable Humanosphere, Kyoto University , Uji , Japan.

Purine permeases (PUPs) mediate the proton-coupled uptake of nucleotide bases and their derivatives into cytosol. PUPs facilitate uptake of adenine, cytokinins and nicotine. Caffeine, a purine alkaloid derived from xanthosine, occurs in only a few eudicot species, including coffee, cacao, and tea. Read More

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http://dx.doi.org/10.1080/09168451.2019.1606698DOI Listing

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.

Cochrane Database Syst Rev 2019 Apr 18;4:CD013308. Epub 2019 Apr 18.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, Oxfordshire, UK, OX2 6GG.

Background: Nicotine replacement therapy (NRT) aims to replace nicotine from cigarettes to ease the transition from cigarette smoking to abstinence. It works by reducing the intensity of craving and withdrawal symptoms. Although there is clear evidence that NRT used after smoking cessation is effective, it is unclear whether higher doses, longer durations of treatment, or using NRT before cessation add to its effectiveness. Read More

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http://dx.doi.org/10.1002/14651858.CD013308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470854PMC
April 2019
1 Read

Impacts of Nicotine and Flavoring on the Sensory Perception of E-Cigarette Aerosol.

Nicotine Tob Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Food Science and Technology, Oregon State University Corvallis, OR, USA.

Introduction: To examine the interaction between an added flavoring (cherry) and nicotine on the perception of electronic cigarette (e-cigarette) aerosol and how this impacts the appeal of flavored e-liquids.

Methods: 19 subjects (13 male, 6 female) vaped 6 commercially available e-liquids with varying contents of nicotine (0, 6, 12 mg/mL) and cherry flavor (4.7 or 9. Read More

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https://academic.oup.com/ntr/advance-article/doi/10.1093/ntr
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http://dx.doi.org/10.1093/ntr/ntz058DOI Listing
April 2019
1 Read

Spectral interval combination optimization (ICO) on rapid quality assessment of plant: a validation study.

J Food Sci Technol 2019 Apr 14;56(4):2158-2166. Epub 2019 Mar 14.

3College of Science, China Agricultural University, Beijing, 100193 People's Republic of China.

A novel spectral variable selection method, named as interval combination optimization (ICO), was proposed in the previous study of us. In the present study, ICO coupled with near infrared (NIR) spectroscopy was applied to the rapid determination of four primary constituents including total sugar, reducing sugar, total nitrogen and nicotine in plant. Partial least squares regressions was performed after ICO algorithm. Read More

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http://dx.doi.org/10.1007/s13197-019-03697-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443740PMC

[Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):197-205

Institute of Systems Biomedicine, State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Science, Beijing 100191, China.

Objective: To investigate functions of proteins and signaling pathways involved in epileptogenesis during the chronic stage of temporal lobe epilepsy in mouse models.

Methods: Kainic acid-induced temporal lobe epilepsy models were conducted, when reaching stage 4 using racine scale, the mice of experimental group were supposed to be successfully established. Pentobarbital sodium was injected to stop epileptic seizure in case of death. Read More

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April 2019
3 Reads

Modulation of 'Protective' Nicotine Perception and Use Profile by Flavorants: Preliminary Findings in E-Cigarettes.

Nicotine Tob Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT.

Introduction: Characterizing flavors are widely available in e-cigarettes and motivate initiation and continued use. Flavors may enhance appeal and facilitate development of addiction to tobacco products through modulation of tobacco products' reinforcing or aversive actions. Palatable flavors (e. Read More

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http://dx.doi.org/10.1093/ntr/ntz057DOI Listing
April 2019
1 Read

Emotional Impact and Perceived Effectiveness of Text-Only versus Graphic Health Warning Tobacco Labels on Adolescents.

Span J Psychol 2019 Apr 17;22:E17. Epub 2019 Apr 17.

ISCTE-Instituto Universitário de Lisboa (Portugal).

The study of smoking in adolescence is of major importance as nicotine dependence often begins in younger groups. Tobacco health warnings have been introduced to inform people of the negative consequences of smoking. This study assessed the emotions and perceived effectiveness of two formats of tobacco warnings on adolescents: Text-only versus graphic warning labels. Read More

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http://dx.doi.org/10.1017/sjp.2019.20DOI Listing

Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley rats.

Psychopharmacology (Berl) 2019 Apr 16. Epub 2019 Apr 16.

Department of Psychology and Collaborative, University of Guelph, Guelph, Ontario, N1H 2GW, Canada.

Rationale: Oleoyl glycine (OlGly), a recently discovered fatty acid amide that is structurally similar to N- acylethanolamines, which include the endocannabinoid, anandamide (AEA), as well as endogenous peroxisome proliferator-activated receptor alpha (PPARα) agonists oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), has been shown to interfere with nicotine reward and dependence in mice.

Objectives And Methods: Behavioral and molecular techniques were used to investigate the ability of OlGly to interfere with the affective properties of morphine and morphine withdrawal (MWD) in male Sprague-Dawley rats.

Results: Synthetic OlGly (1-30 mg/kg, intraperitoneal [ip]) produced neither a place preference nor aversion on its own; however, at doses of 1 and 5 mg/kg, ip, it blocked the aversive effects of MWD in a place aversion paradigm. Read More

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http://dx.doi.org/10.1007/s00213-019-05237-9DOI Listing
April 2019
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Intrinsic insular-frontal networks predict future nicotine dependence severity.

J Neurosci 2019 Apr 16. Epub 2019 Apr 16.

Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD, 21224

Although 60% of the US population have tried smoking cigarettes, only 16% smoke regularly. Identifying this susceptible subset of the population before the onset of nicotine dependence may encourage targeted early interventions to prevent regular smoking and/or minimize severity. While prospective neuroimaging in human populations can be challenging, preclinical neuroimaging models prior to chronic nicotine administration can help develop translational biomarkers of disease risk. Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0140-1
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http://dx.doi.org/10.1523/JNEUROSCI.0140-19.2019DOI Listing
April 2019
2 Reads

What Factors Influence Non-Adherence to the Smoking Cessation Program?

Turk Thorac J 2019 Apr 1. Epub 2019 Apr 1.

Clinic of Pulmonary Diseases, Health Sciences University, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey.

Objectives: To improve our knowledge and understand how to deal with non-adherence to the support programs and to determine the rate and possible factors related to non-adherence in subjects who attended our smoking cessation clinic.

Materials And Methods: This was a case-control study that included 550 subjects who applied to our smoking cessation clinic between June 1, 2011 and December 31, 2011. After a 1-year follow-up period, subjects were divided into two groups: adherent (controls) and non-adherent (cases). Read More

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http://turkthoracj.org/eng/makale/1102/154/Full-Text
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http://dx.doi.org/10.5152/TurkThoracJ.2018.18040DOI Listing
April 2019
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Unprecedented Ultralow Detection Limit of Amines using a Thiadiazole-Functionalized Zr(IV)-Based Metal-Organic Framework.

J Am Chem Soc 2019 Apr 24. Epub 2019 Apr 24.

A luminescent Zr(IV)-based metal-organic framework (MOF), with the underlying fcu topology, encompassing a π-conjugated organic ligand with a thiadiazole functionality, exhibits an unprecedented low detection limit of 66 nM for amines in aqueous solution. Markedly, this ultralow detection is driven by hydrogen-bonding interactions between the linker and the hosted amines. This observation is supported by density functional theory (DFT) calculations, which clearly corroborate the suppression of the twisting motion of thiadiazole core in the presence of amine, reducing significantly the nonradiative recombination pathways and subsequently enhancing the emission intensity. Read More

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http://dx.doi.org/10.1021/jacs.9b01839DOI Listing

Exposure to Potentially Harmful E-Cigarette Emissions via Vape Tricks: Protocol for a Mixed-Methods Study.

JMIR Res Protoc 2019 Apr 15;8(4):e12304. Epub 2019 Apr 15.

Center for Health Policy Science and Tobacco Research, RTI International, Research Triangle Park, NC, United States.

Background: The number of adolescents and adults using e-cigarettes, referred to as vaping, has dramatically increased. E-cigarettes can be used to perform vape tricks by inhaling and exhaling the e-cigarette aerosol in patterns to create visual effects or large clouds. To create these effects, the puffing patterns associated with vape tricks may be different than standard ad-lib e-cigarette usage. Read More

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http://dx.doi.org/10.2196/12304DOI Listing

Types of cannabis and tobacco/nicotine co-use and associated outcomes in young adulthood.

Psychol Addict Behav 2019 Apr 15. Epub 2019 Apr 15.

RAND Corporation.

Cannabis and tobacco/nicotine use are highly comorbid. Given expanding access to cannabis through legalization for recreational use, it is important to understand how patterns of cannabis and tobacco/nicotine co-use are associated with young adult outcomes. A predominantly California-based sample of 2,429 young adults (mean age = 20. Read More

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http://doi.apa.org/getdoi.cfm?doi=10.1037/adb0000464
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http://dx.doi.org/10.1037/adb0000464DOI Listing
April 2019
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Nicotinic Agonist Inhibits Cardiomyocyte Apoptosis in CVB3-Induced Myocarditis via 34-nAChR/PI3K/Akt-Dependent Survivin Upregulation.

Oxid Med Cell Longev 2019 7;2019:9496419. Epub 2019 Mar 7.

Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Institute of Cardiovascular Development and Translational Medicine, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

Background: Cardiomyocyte apoptosis is critical for the development of coxsackievirus B3- (CVB3-) induced myocarditis, which is a common cardiac disease that may result in heart failure or even sudden death. Previous studies have associated CVB3-induced apoptosis with the downregulation of antiapoptotic proteins. Here, attempts were made to examine whether nicotinic acetylcholine receptors (nAChRs), especially 34-nAChRs, were a novel therapeutic antiapoptotic target via the activation of survivin, a strong antiapoptotic protein, in viral myocarditis (VMC). Read More

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https://www.hindawi.com/journals/omcl/2019/9496419/
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http://dx.doi.org/10.1155/2019/9496419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431489PMC
March 2019
2 Reads

Motivational Benefits of Social Support and Behavioural Interventions for Smoking Cessation.

J Smok Cessat 2018 Dec 21;13(4):216-226. Epub 2018 Jan 21.

Department of Internal Medicine, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd., Orlando, FL 32827; 1(407) 266-7149.

This study examined the role of social support and behavioral interventions used during the last unsuccessful quit attempt for smokers' intentions to quit smoking within the next 6 months, and identified smokers' attributes associated with use of social support and behavioral interventions. The analytic sample included 7,195 adult daily smokers who responded to the 2010-2011 Tobacco Use Supplement to the Current Population Survey, conducted in the US, and indicated having a serious quit attempt in the past 12 months. Smokers who relied on social support from friends and family had higher odds of intending to quit than those who did not (OR= 1. Read More

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http://dx.doi.org/10.1017/jsc.2017.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459678PMC
December 2018

Cigarette smoke reduces short chain fatty acid production by a Porphyromonas gingivalis clinical isolate.

J Periodontal Res 2019 Apr 14. Epub 2019 Apr 14.

Departments of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky.

Objectives: We hypothesized that short chain fatty acid (SCFA) production by oral pathogens is suppressed by exposure to cigarette smoke extract (CSE).

Background: Tobacco smoking is a major risk factor for plaque-induced periodontal diseases. Despite increased disease susceptibility, overt oral inflammation is suppressed in smokers, presenting a diagnostic conundrum. Read More

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http://dx.doi.org/10.1111/jre.12660DOI Listing
April 2019
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Sex Differences in the Reward-Enhancing Effects of Nicotine on Ethanol Reinforcement: A Reinforcer Demand Analysis.

Nicotine Tob Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychology, University of Nebraska - Lincoln.

Background: Alcohol is often consumed with tobacco, and dependence to alcohol and tobacco are highly comorbid. Additionally, there are differences in the prevalence of nicotine- and alcohol-abuse between the sexes. Nicotine produces enhancing effects on the value of other reinforcers, which may extend to alcohol. Read More

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http://dx.doi.org/10.1093/ntr/ntz056DOI Listing

Clinical Efficacy of Telemedicine Compared with Face-to-face Clinic Visit on Smoking Cessation: A Multi-center, Open-label, Randomized Controlled, Non-inferiority Trial.

J Med Internet Res 2019 Apr 11. Epub 2019 Apr 11.

CureApp Institute, 4136-1 Yokozawa Nagakura, Karuizawa, JP.

Background: Tobacco is a major public health concern. A 12-week standard smoking cessation program is available in Japan; however, its required face-to-face clinic visits has been one of the key obstacles to completing the program, leading to a low smoking cessation success rate. Telemedicine using an internet-based video counseling instead of regular clinic visits could address the obstacles. Read More

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http://dx.doi.org/10.2196/13520DOI Listing

The rate of postoperative pancreatic fistula after distal pancreatectomy is independent of the pancreatic stump closure technique - A retrospective analysis of 284 cases.

Asian J Surg 2019 Apr 11. Epub 2019 Apr 11.

Medical Center - University of Freiburg, Center for Surgery, Department of General and Visceral Surgery, Germany.

Background: Many techniques have been developed to prevent postoperative pancreatic fistula (POPF) after distal pancreatectomy, but POPF rates remain high. The aim of our study was to analyze POPF occurrence after closure of the pancreatic remnant by different operative techniques.

Methods: Between 2006 and 2017, 284 patients underwent distal pancreatectomy in our institution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10159584193003
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http://dx.doi.org/10.1016/j.asjsur.2019.03.009DOI Listing
April 2019
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To smoke or not to smoke: Does delay discounting affect the proximal choice to smoke?

Subst Use Misuse 2019 Apr 13:1-10. Epub 2019 Apr 13.

a Roswell Park Comprehensive Cancer Center, Elm & Carlton , Buffalo , New York , USA.

Background: Delay discounting rate shows robust predictive validity for tobacco use behaviors and is a new therapeutic target in the treatment of tobacco use. Identifying factors that influence relations between delay discounting and the choice to smoke cigarettes is key to the development of effective interventions that target delay discounting to reduce cigarette consumption.

Objective: To examine relations between delay discounting, motivational factors, self-efficacy, nicotine dependence level, and the proximal choice to smoke in the context of other commonly rewarding activity choices. Read More

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https://www.tandfonline.com/doi/full/10.1080/10826084.2018.1
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http://dx.doi.org/10.1080/10826084.2018.1528463DOI Listing
April 2019
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Effects of stimulant drug use on the dopaminergic system: A systematic review and meta-analysis of in vivo neuroimaging studies.

Eur Psychiatry 2019 Apr 11;59:15-24. Epub 2019 Apr 11.

Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany. Electronic address:

Background: Stimulant drugs can cause persistent changes in the brain. Imaging studies show that these changes are most apparent in dopamine transporter (DAT) or receptor availability within the striatum.

Methods: This work focuses on influences of stimulant use on dopaminergic function assessed using nuclear-medicine imaging (PET/SPECT). Read More

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http://dx.doi.org/10.1016/j.eurpsy.2019.03.003DOI Listing
April 2019
1 Read