46,026 results match your criteria Nicotine & Tobacco Research[Journal]


"Cold turkey" or pharmacotherapy: Examination of tobacco cessation methods tried among smokers prior to developing head and neck cancer.

Head Neck 2019 Feb 15. Epub 2019 Feb 15.

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

Background: Tobacco cessation methods employed by patients with head and neck cancer (HNSCC) are previously unstudied and have the potential to inform choice of cessation method and necessary abstinence support.

Methods: A total of 130 current smokers with HNSCC were queried regarding prior unsuccessful tobacco cessation techniques, product used (cold turkey, varenicline, and nicotine patch/gum), and maximum time abstained from smoking.

Results: One hundred six smokers retrospectively reported using one of the four main quit methods. Read More

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http://dx.doi.org/10.1002/hed.25708DOI Listing
February 2019

Randomised controlled trial of real-time feedback and brief coaching to reduce indoor smoking.

Tob Control 2019 Feb 15. Epub 2019 Feb 15.

Center for Behavioral Epidemiology and Community Health, Graduate School of Public Health, San Diego State University, San Diego, California, USA.

Background: Previous secondhand smoke (SHS) reduction interventions have provided only feedback on reported smoking behaviour, such as coaching, or presenting results from child cotinine assays or air particle counters.

Design: This SHS reduction trial assigned families at random to brief coaching and continuous real-time feedback (intervention) or measurement-only (control) groups.

Participants: We enrolled 298 families with a resident tobacco smoker and a child under age 14. Read More

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http://dx.doi.org/10.1136/tobaccocontrol-2018-054717DOI Listing
February 2019

[Coffee, Cigarettes, Chewing Gum - Myths and Facts About Preoperative Fasting].

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Feb 15;54(2):142-145. Epub 2019 Feb 15.

Consumption of clear liquids (including coffee and orange juice without pulp) up to 2 hours before the start of anaesthesia is unproblematic. Contrary to the recommendations of the professional societies, the intake of beverages containing milk (up to 50% of the total volume) in small quantities seems to be harmless. Drinks containing alcohol can considerably delay emptying of the stomach. Read More

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http://dx.doi.org/10.1055/s-0043-124943DOI Listing
February 2019

Electronic cigarette and tobacco use in individuals entering methadone or buprenorphine treatment.

Drug Alcohol Depend 2019 Jan 17;197:37-41. Epub 2019 Jan 17.

Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA; APT Foundation, New Haven, CT, USA.

Background: Although smoking is prevalent among populations with opioid use disorder (OUD), few studies have examined electronic cigarette (EC) use in individuals seeking opioid agonist therapy (OAT). The aim of this study was to evaluate the prevalence and correlates of EC use among individuals seeking OAT.

Methods: 782 patients seeking OAT for OUD completed surveys assessing current and past EC use, reasons for use, current and past cigarette smoking, nicotine dependence, psychiatric distress, trauma, and pain. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.12.012DOI Listing
January 2019

Goal-Directed and Habitual Control in Smokers.

Nicotine Tob Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.

Introduction: Harmful behavior such as smoking may reflect a disturbance in the balance of goal-directed and habitual control. Animal models suggest that habitual control develops after prolonged substance use. In this study, we investigated whether smokers (N = 49) differ from controls (N = 46) in the regulation of goal-directed and habitual behavior. Read More

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http://dx.doi.org/10.1093/ntr/ntz001DOI Listing
February 2019

Feasibility and early outcomes of a tailored quitline protocol for smokers with mental health conditions.

Nicotine Tob Res 2019 Feb 15. Epub 2019 Feb 15.

Optum Healthcare Analytics.

Introduction: Adults with mental health conditions (MHCs) smoke at higher rates, are more nicotine dependent, and have more trouble quitting smoking than those without MHCs. About half of smokers who call state-funded quitlines report MHCs, and those with such conditions have cessation rates 8-10% lower than those without MHCs. This paper describes a clinical pilot of a tailored protocol for quitline callers with MHCs. Read More

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http://dx.doi.org/10.1093/ntr/ntz023DOI Listing
February 2019

Non-Pharmacological Treatments for Tobacco Users with Mental Health Symptoms.

Nicotine Tob Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Behavioral and Social Sciences, Center for Alcohol & Addiction Studies, Brown University School of Public Health, Providence RI, USA.

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http://dx.doi.org/10.1093/ntr/ntz024DOI Listing
February 2019

E-cigarettes and smoking cessation in the United States according to frequency of e-cigarette use and quitting duration: analysis of the 2016 and 2017 National Health Interview Surveys.

Nicotine Tob Res 2019 Feb 15. Epub 2019 Feb 15.

Departments of Social and Behavioral Science and Epidemiology, College of Global Public Health, New York University.

Introduction: The study purpose was to examine the association between electronic cigarette (e-cigarette) use and smoking cessation among United States (US) adults. Duration of smoking cessation was taken into consideration since e-cigarette awareness and use were low in the US before 2010.

Methods: Pooled analysis of the 2016 and 2017 National Health Interview Surveys on current (N=9935) and former smokers (N=14754) was performed. Read More

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http://dx.doi.org/10.1093/ntr/ntz025DOI Listing
February 2019

Interaction of nicotinic acetylcholine receptors with dopamine receptors in synaptic plasticity of the mouse insular cortex.

Authors:
Hiroki Toyoda

Synapse 2019 Feb 14. Epub 2019 Feb 14.

Department of Oral Physiology, Osaka University Graduate School of Dentistry, Suita, 565-0871, Japan.

The insular cortex plays essential roles in nicotine addiction. However, much is still unknown about its cellular and synaptic mechanisms responsible for nicotine addiction. We have previously shown that in layer 5 pyramidal neurons of the mouse insular cortex, activation of nicotinic acetylcholine receptors (nAChRs) suppresses synaptic potentiation through enhancing GABAergic synaptic transmission although it enhances both glutamatergic and GABAergic synaptic transmission. Read More

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http://dx.doi.org/10.1002/syn.22094DOI Listing
February 2019

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism.

Transl Psychiatry 2019 Feb 14;9(1):89. Epub 2019 Feb 14.

Department of Neuroscience, Icahn School of Medicine at Mt. Sinai, 1425 Madison Ave, New York, NY, USA.

Alcohol exposure triggers changes in gene expression and biological pathways in human brain. We explored alterations in gene expression in the Pre-Frontal Cortex (PFC) of 65 alcoholics and 73 controls of European descent, and identified 129 genes that showed altered expression (FDR < 0.05) in subjects with alcohol dependence. Read More

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http://dx.doi.org/10.1038/s41398-019-0384-yDOI Listing
February 2019

Clinical evaluation of deep brain stimulation of nucleus accumbens/anterior limb of internal capsule for opioid relapse prevention: protocol of a multicentre, prospective and double-blinded study.

BMJ Open 2019 Feb 13;9(2):e023516. Epub 2019 Feb 13.

National Institute on Drug Dependence, Peking University, Beijing, China.

Introduction: Deep brain stimulation (DBS) is a new potential surgical treatment for opioid dependence. However, the implement of DBS treatment in addicted patients is currently controversial due to the significant associated risks. The aim of this study was mainly to investigate the therapeutic efficacy and safety of bilateral DBS of nucleus accumbens and the anterior limb of the internal capsule (NAc/ALIC-DBS) in patients with refractory opioid dependence (ROD). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023516DOI Listing
February 2019

High Carbon Monoxide Levels from Charcoal Combustion Mask Acute Endothelial Dysfunction Induced by Hookah (Waterpipe) Smoking in Young Adults.

Circulation 2019 Feb 15. Epub 2019 Feb 15.

Cedars-Sinai Smidt Heart Institute, CA.

Background: Hookah smoking is marketed to youth as a harmless alternative to cigarettes. While cigarette smoking acutely impairs endothelial function, the effect of smoking fruit flavored hookah tobacco is unknown. Because charcoal traditionally is used to heat the hookah tobacco in the waterpipe, hookah smoke delivers tobacco toxicants and nicotine plus charcoal combustion products: not only carbon-rich nanoparticles-oxidants that may destroy nitric oxide and impair endothelial function-but also large amounts of carbon monoxide (CO), a putative vasodilator molecule. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037375DOI Listing
February 2019

Differences in Prenatal Tobacco Exposure Patterns among 13 Race/Ethnic Groups in California.

Int J Environ Res Public Health 2019 Feb 5;16(3). Epub 2019 Feb 5.

Environmental Health Investigations Branch, California Department of Public Health (CDPH), Richmond, CA 94804, USA.

Prenatal tobacco exposure is a significant, preventable cause of childhood morbidity, yet little is known about exposure risks for many race/ethnic subpopulations. We studied active smoking and environmental tobacco smoke (ETS) exposure in a population-based cohort of 13 racially/ethnically diverse pregnant women: white, African American, Hispanic, Native American, including nine Asian/Pacific Islander subgroups: Chinese, Japanese, Korean, Filipino, Cambodian, Vietnamese, Laotian, Samoan, and Asian Indians (N = 3329). Using the major nicotine metabolite, cotinine, as an objective biomarker, we analyzed mid-pregnancy serum from prenatal screening banked in 1999⁻2002 from Southern California in an effort to understand differences in tobacco exposure patterns by race/ethnicity, as well as provide a baseline for future work to assess secular changes and longer-term health outcomes. Read More

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http://dx.doi.org/10.3390/ijerph16030458DOI Listing
February 2019

Orexin facilitates GABAergic IPSCs via postsynaptic OX receptors coupling to the intracellular PKC signalling cascade in the rat cerebral cortex.

Neuropharmacology 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan; Division of Oral and Craniomaxillofacial Research, Dental Research Centre, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan; Molecular Dynamics Imaging Unit, RIKEN Centre for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, 650-0047, Japan. Electronic address:

Orexin has multiple physiological functions including wakefulness, appetite, nicotine intake, and nociception. The cerebral cortex receives abundant orexinergic projections and expresses both orexinergic receptor 1 (OXR) and 2 (OXR). However, little is known about orexinergic regulation of GABA-mediated inhibitory synaptic transmission. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.012DOI Listing
February 2019

What is new in electronic-cigarettes research?

Curr Opin Pediatr 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.

Purpose Of Review: Electronic cigarettes (e-cigarettes) and other vaping devices have seen extraordinary growth in use in the past 10 years, and companies are accelerating their development of new products and marketing efforts. In turn, researchers have increased their efforts to determine how e-cigarettes affect health, how marketing these products impacts adolescents and how the use of e-cigarettes may affect adolescents' use of other tobacco products. Products like Juul were not on the market 2 years ago; thus, frequent updates on the topic are essential. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000741DOI Listing
February 2019

Genome-wide expression analysis reveals six contravened targets of EZH2 associated with breast cancer patient survival.

Sci Rep 2019 Feb 13;9(1):1974. Epub 2019 Feb 13.

Cancer Biology Laboratory, Department of Cancer Biology, Institute of Life Sciences, Bhubaneswar, Odisha, India.

Several pioneering work have established that apart from genetic alterations, epigenetic modifications contribute significantly in tumor progression. Remarkable role of EZH2 in cancer highlights the importance of identifying its targets. Although much emphasis has been placed in recent years in designing drugs and inhibitors targeting EZH2, less effort has been given in exploring its existing targets that will help in understanding the oncogenic role of EZH2 in turn which may provide a more stringent method of targeting EZH2. Read More

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http://www.nature.com/articles/s41598-019-39122-4
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http://dx.doi.org/10.1038/s41598-019-39122-4DOI Listing
February 2019
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Association of smoking and electronic cigarette use with wheezing and related respiratory symptoms in adults: cross-sectional results from the Population Assessment of Tobacco and Health (PATH) study, wave 2.

Tob Control 2019 Feb 13. Epub 2019 Feb 13.

Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.

Background: Wheezing is a symptom of potential respiratory disease and known to be associated with smoking. Electronic cigarette use ('vaping') has increased exponentially in recent years. This study examined the cross-sectional association of vaping with wheezing and related respiratory symptoms and compare this association with smokers and dual users. Read More

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http://dx.doi.org/10.1136/tobaccocontrol-2018-054694DOI Listing
February 2019

Emotion regulation and motives for illicit drug use in opioid-dependent patients.

Cogn Behav Ther 2019 Feb 14:1-7. Epub 2019 Feb 14.

a Department of Psychological and Brain Sciences , Boston University , Boston , MA , USA.

Refining the mechanisms behind illicit drug use is an important factor for improving the quality of clinical care. Research in alcohol, marijuana, and nicotine use disorders have linked coping motives (e.g. Read More

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http://dx.doi.org/10.1080/16506073.2019.1579256DOI Listing
February 2019

First Report of Arabis mosaic virus on Grapevine in Spain.

Plant Dis 2010 May;94(5):635

NEIKER-Basque Institute for Agricultural Research and Development, E-01080 Vitoria/Gasteiz, Spain. Research funded by projects RTA2008-00064 and RTA2008-00078-C03 from INIA.

Arabis mosaic virus (ArMV; genus Nepovirus, family Comoviridae) is one of several nepoviruses responsible for infectious degeneration disease of grapevines in Europe (3). The first occurrence in Spain, in the summer of 2007, was found in Val de Salnés, Rias Baixas appellation, Galice on 25-year-old vines of the Albariño variety grafted onto an unidentified rootstock and showing leaf yellowing. The second finding was in the spring of 2008 in Barriobusto, Rioja appellation, Basque Country on 30-year-old vines of Tempranillo variety grafted onto 41B rootstock. Read More

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http://dx.doi.org/10.1094/PDIS-94-5-0635ADOI Listing

Smoking among Immigrant Groups in the United States: Prevalence, Education Gradients, and Male-to-Female Ratios.

Nicotine Tob Res 2019 Feb 13. Epub 2019 Feb 13.

Institut National de la Statistique et des Etudes Economiques (Insee), Montrouge, France.

Introduction: Immigrants in the United States are less likely to smoke than those born in the U.S, but studies have not fully described the diversity of their smoking patterns. We investigate smoking by world region of birth and duration of residence in the United States, with a comprehensive approach covering current prevalence levels, education gradients, and male-to-female ratios. Read More

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http://dx.doi.org/10.1093/ntr/ntz022DOI Listing
February 2019

Prevalence of smoking and knowledge about the smoking hazards among 170,000 Chinese adults: a nationally representative survey in 2013-2014.

Nicotine Tob Res 2019 Feb 13. Epub 2019 Feb 13.

National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Introduction: Periodic population surveys of smoking behaviour can inform development of effective tobacco control strategies. We investigated smoking patterns, cessation and knowledge about smoking hazards in China.

Methods: A nationally representative cross-sectional survey recruited 176,318 people aged ≥18 years across 31 provinces of China in 2013-14, using multi-stage stratified cluster sampling methods. Read More

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http://dx.doi.org/10.1093/ntr/ntz020DOI Listing
February 2019

The price of Natural American Spirit relative to other cigarette brands.

Nicotine Tob Res 2019 Feb 13. Epub 2019 Feb 13.

Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine.

Introduction: American Spirit cigarettes feature American Indian/Alaska Native (AI/AN) imagery in the branding, are marketed as environmentally friendly, without additives, and four varieties contain organic tobacco. This study is the first to examine retail price of American Spirit relative to other cigarette brands and to assess how its price varies by neighborhood demography.

Methods: In a random sample of licensed tobacco retailers (n=1277), trained data collectors recorded availability and price of American Spirit, Pall Mall, Newport, Marlboro and the cheapest cigarettes regardless of brand. Read More

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http://dx.doi.org/10.1093/ntr/ntz018DOI Listing
February 2019

Characterization of Volatile Organic Compound (VOC) metabolites in Cigarette smokers, Electronic Nicotine Device Users, Dual Users and Non- users of tobacco.

Nicotine Tob Res 2019 Feb 13. Epub 2019 Feb 13.

University of Louisville School of Medicine. Louisville, KY.

Introduction: Limited research exists about the possible cardiovascular effects of electronic nicotine delivery devices (ENDS). We therefore sought to compare exposure to known or potentially cardio-toxic volatile organic compounds (VOCs) in ENDS users, smokers, and dual users.

Methods: 371 individuals from the Cardiovascular Injury due to Tobacco Use study, a cross-sectional study of healthy participants aged 21-45 years were categorized as non-users of tobacco (n=87), sole ENDS users (n=17), cigarette smokers (n=237) and dual users (n=30) based on 30-day self-reported tobacco product use patterns. Read More

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http://dx.doi.org/10.1093/ntr/ntz021DOI Listing
February 2019

Therapeutic challenges for concurrent ethanol and nicotine consumption: naltrexone and varenicline fail to alter simultaneous ethanol and nicotine intake by female alcohol-preferring (P) rats.

Psychopharmacology (Berl) 2019 Feb 13. Epub 2019 Feb 13.

Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Neuroscience Research Building, 320 W. 15th Street, Suite 300B, Indianapolis, IN, 46202-2266, USA.

Rationale And Objectives: Simultaneous alcohol and nicotine consumption occurs in the majority of individuals with alcohol use disorder (AUD) and nicotine dependence. Varenicline (Var) is used to assist in the cessation of nicotine use, while naltrexone (Nal) is the standard treatment for AUD. Despite evidence that ethanol (EtOH) and nicotine (NIC) co-use produces unique neuroadaptations, preclinical research has focused on the effects of pharmacotherapeutics on a single reinforcer. Read More

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http://dx.doi.org/10.1007/s00213-019-5174-yDOI Listing
February 2019

Relapse prevention interventions for smoking cessation.

Cochrane Database Syst Rev 2019 Feb 13;2:CD003999. Epub 2019 Feb 13.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: A number of treatments can help smokers make a successful quit attempt, but many initially successful quitters relapse over time. Several interventions have been proposed to help prevent relapse.

Objectives: To assess whether specific interventions for relapse prevention reduce the proportion of recent quitters who return to smoking. Read More

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http://doi.wiley.com/10.1002/14651858.CD003999.pub5
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http://dx.doi.org/10.1002/14651858.CD003999.pub5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372978PMC
February 2019
1 Read

E-cigarettes Best Other Cessation Tools.

Authors:

Cancer Discov 2019 Feb 12. Epub 2019 Feb 12.

Electronic cigarettes (e-cigarettes) may be an effective tool for smoking cessation. In a randomized trial, researchers found that 18% of those assigned to use e-cigarettes were smoke-free after a year, compared with 9.9% of those assigned to nicotine replacement therapies such as patches and gum. Read More

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http://dx.doi.org/10.1158/2159-8290.CD-NB2019-018DOI Listing
February 2019

Nicotine and Its Action upon the Teeth.

Authors:
David Hepburn

Am J Dent Sci 1883 Jul;17(3):122-126

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043222PMC

How much is too much? Estimating effective price-hikes to affect smoking behavior in Vietnam.

Nicotine Tob Res 2019 Feb 9. Epub 2019 Feb 9.

Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.

Methods: A cross-sectional survey was conducted with 822 male current smokers in Da Nang, Vietnam. A structured questionnaire was adapted from the International Tobacco Control (ITC) project survey. Bayesian quantile regression was applied to predict factors associated with expected cigarette price. Read More

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http://dx.doi.org/10.1093/ntr/ntz017DOI Listing
February 2019

Impact of menthol on oral nicotine consumption in female and male Sprague Dawley rats.

Nicotine Tob Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacology, Faculty of Medicine, Uludag University, Bursa, Turkey.

Introduction: One of the most preferable flavors in oral nicotine delivery systems is menthol which masks the harshness of tobacco. However, possible interactions between oral menthol and nicotine on intake and preference remain unclear. Therefore, we aimed to determine the impact of menthol on oral nicotine consumption. Read More

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http://dx.doi.org/10.1093/ntr/ntz019DOI Listing
February 2019
1 Read

Estrogen reverses nicotine-induced inflammation in chondrocytes via reducing the degradation of ECM.

Int J Rheum Dis 2019 Feb 11. Epub 2019 Feb 11.

Laboratory Animal Center of Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai, China.

Problem: Osteoarthritis (OA) is a chronic disease with a very high incidence and the pathology of which is quite complex. Epidemiological investigation showed that OA may be related to smoking and estrogen levels, but there are few studies focused on the cross-effect of these two factors. This research aims to investigate the molecular mechanism of nicotine and estrogen effects on chondrocytes to study the effect of smoking on the incidence of osteoarthritis in women. Read More

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http://dx.doi.org/10.1111/1756-185X.13476DOI Listing
February 2019
2 Reads

Addiction and Dopamine: Sex Differences and Insights from Studies of Smoking.

Curr Opin Behav Sci 2018 Oct 27;23:150-159. Epub 2018 Jul 27.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA, 90024.

Mesolimbic dopaminergic function influences addiction through effects on reinforcement learning, decision-making, and impulsivity. This review covers sex differences in dopaminergic neurochemistry, their hormonal and genetic determinants, and how differences in dopaminergic tone interact with sex and/or ovarian hormone status to affect cognitive functions. Findings from research on cigarette smoking reveal sex differences in striatal and midbrain dopamine D2-type receptor availability and striatal dopamine release that suggest mechanisms of nicotine dependence, and stronger subjective responses to nicotine and efficacy of nicotine replacement therapies in male smokers than in their female counterparts. Read More

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http://dx.doi.org/10.1016/j.cobeha.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368096PMC
October 2018

Electronic cigarette among health science students in Saudi Arabia.

Ann Thorac Med 2019 Jan-Mar;14(1):56-62

Department of Medicine, University of Jeddah, Jeddah, Saudi Arabia.

Background: Electronic cigarette (E-cigarette) is an electronic nicotine delivery device that has been advocated as a safe alternative for cigarette smokers. Since the introduction of E-cigarette internationally and in the Kingdom of Saudi Arabia (KSA), it gained popularity, particularly among the youth and young adults. Moreover, many nonsmoker (nicotine-naïve) youth started to use E-cigarette as a new social habit. Read More

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http://dx.doi.org/10.4103/atm.ATM_76_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341860PMC
February 2019

A study on the prevalence and correlates of nicotine dependence among adolescents of Burdwan Town, West Bengal.

Indian J Psychiatry 2019 Jan-Feb;61(1):89-93

Department of Pediatrics, Burdwan Medical College, Burdwan, West Bengal, India.

Context: Tobacco will cause one billion deaths in the 21 century. The use of tobacco causes dependence both psychological and physical.

Aims: To find out the level of nicotine dependence and it correlates among adolescents. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_112_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341911PMC
February 2019

Characteristics and toxicant emissions of JUUL electronic cigarettes.

Tob Control 2019 Feb 11. Epub 2019 Feb 11.

Department of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.

Introduction: JUUL is an electronic cigarette (ECIG) with a compact form factor. It is prefilled with a liquid that is advertised to contain a high concentration of nicotine salt. JUUL commands 50% of the US ECIG market share, and its wide popularity with underage users has triggered unprecedented actions by the US FDA. Read More

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http://tobaccocontrol.bmj.com/lookup/doi/10.1136/tobaccocont
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http://dx.doi.org/10.1136/tobaccocontrol-2018-054616DOI Listing
February 2019
6 Reads

Smoking related outcomes before and after implementation of tobacco-free grounds in residential substance use disorder treatment programs.

Drug Alcohol Depend 2019 Feb 5;197:8-14. Epub 2019 Feb 5.

Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, CA, USA; Department of Psychiatry and Weill Institute for Neuroscience, University of California San Francisco, CA, USA.

Background: This study examined the impact of a tobacco-free grounds (TFG) policy and the California $2.00/pack tobacco tax increase on tobacco use among individuals in residential substance use disorder (SUD) treatment.

Methods: We conducted three cross-sectional surveys of clients enrolled in three residential SUD treatment programs. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.001DOI Listing
February 2019
1 Read

Very-low-nicotine-content cigarettes and dependence among non-daily smokers.

Drug Alcohol Depend 2019 Jan 31;197:1-7. Epub 2019 Jan 31.

University of Pittsburgh, Department of Biostatistics, Pittsburgh, PA, USA.

Background: The US Food and Drug Administration is considering reductions in the nicotine content of cigarettes to reduce smoking and tobacco dependence. A randomized study showed that even non-daily, intermittent smokers (ITS) reduced their cigarette consumption when switched to very-low-nicotine-content cigarettes (VLNCCs). This paper assesses whether switching ITS to VLNCCs results in decreased dependence and whether subsequent cigarette consumption is mediated by decreased dependence. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.12.021DOI Listing
January 2019

Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.

Neuropharmacology 2019 Feb 8;149:66-82. Epub 2019 Feb 8.

Institute for Behavioral Genetics, University of Colorado, Boulder, United States.

Maternal smoking during pregnancy, a form of developmental nicotine exposure (DNE), is associated with increased nicotine use and neurodevelopmental disorders such as ADHD in children. Here, we characterize the behavioral, rhythmometric, neuropharmacological, and epigenetic consequences of DNE in the F1 (first) and F2 (second) generation adolescent offspring of mice exposed to nicotine prior to and throughout breeding. We assessed the effects of passive oral methylphenidate (MPH) administration and voluntary nicotine consumption on home cage activity rhythms and activity and risk-taking behaviors in the open field. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.006DOI Listing
February 2019

Rapid and sensitive detection of NADPH via mBFP-mediated enhancement of its fluorescence.

PLoS One 2019 11;14(2):e0212061. Epub 2019 Feb 11.

Department of Biological Sciences and Research Center of Ecomimetics, Chonnam National University, Gwangju, Republic of Korea.

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) functions as a reducing agent involved in many biosynthetic and antioxidant reactions in cells. Therefore, a lots of detection or assaying method of this cofactor are developed and used broadly in various research and application fields. These detection or assay tools, however, have often some problems, such as the low sensitivity, susceptibility to environmental interference and time-consuming pretreatment steps, remaining hurdle to successful quantification of NADPH or its derivatives accurately and immediately. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212061PLOS
February 2019

A Novel Smoking Cessation Smartphone App Integrated With a Mobile Carbon Monoxide Checker for Smoking Cessation Treatment: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc 2019 Feb 11;8(2):e12252. Epub 2019 Feb 11.

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Background: Smoking cessation treatment programs have been widely available for patients with nicotine dependence. Despite intensive programs, the continuous abstinence rate (CAR) from weeks 9-12 is still about 50%. Recently, a smartphone app emerged as a novel tool for therapeutic interventions, including nicotine dependence. Read More

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http://dx.doi.org/10.2196/12252DOI Listing
February 2019
1 Read

Comparison of the content of tobacco alkaloids and tobacco-specific nitrosamines in 'heat-not-burn' tobacco products before and after aerosol generation.

Inhal Toxicol 2019 Feb 11:1-7. Epub 2019 Feb 11.

a Department of Industrial Plant Science & Technology , Chungbuk National University , Cheongju , Chungbuk , Republic of Korea.

Standardized methods for collecting smoke and for measuring smoke components in heat not burn tobacco product (HTP) are yet to be established, and there is a lack of consensus as to whether the content of HTP cigarettes can be assayed in the same manner as for conventional cigarettes. Since HTPcigarettes do not generate ash when smoked, we compared the levels of tobacco alkaloids (TAs) and tobacco-specific nitrosamines (TSNAs) of HTP cigarettes before and after aerosol generation. HTP cigarettes were smoked according to two international standardization methods. Read More

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http://dx.doi.org/10.1080/08958378.2019.1572840DOI Listing
February 2019

Demonstration of critical role of GRIN3A in nicotine dependence through both genetic association and molecular functional studies.

Addict Biol 2019 Feb 11. Epub 2019 Feb 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, China.

Nicotine dependence (ND) is a chronic disease with catastrophic effects on individual and public health. The glutamate receptor subunit gene, ionotropic N-methyl-d-aspartate 3A (GRIN3A), encodes a crucial subunit of N-methyl-d-aspartate receptors (NMDARs), which play an essential role in synaptic plasticity in the brain. Although various variants of GRIN3A have been associated with ND in European-American and African-American samples, no study has been reported for the association between GRIN3A and ND in Chinese Han population. Read More

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http://dx.doi.org/10.1111/adb.12718DOI Listing
February 2019

Nicotine induces cell survival and chemoresistance by stimulating Mcl-1 phosphorylation and its interaction with Bak in lung cancer.

J Cell Physiol 2019 Feb 11. Epub 2019 Feb 11.

Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Nicotine is a major carcinogen in cigarettes, which can enhance cell proliferation and metastasis and increase the chemoresistance of cancer cells. Our previous data found that nicotine promotes cell survival in lung cancer by affecting the expression of antiapoptotic protein Mcl-1, suggesting that the Mcl-1 may be a therapeutic target for patients with lung cancer. In this study, we found that the effects of drug resistance on nicotine-induced lung cancer cell lines were shown to influence the phosphorylation of Mcl-1. Read More

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http://dx.doi.org/10.1002/jcp.28251DOI Listing
February 2019

Feeling Hopeful Motivates Change: Emotional Responses to Messages Communicating Comparative Risk of Electronic Cigarettes and Combusted Cigarettes.

Health Educ Behav 2019 Feb 10:1090198118825236. Epub 2019 Feb 10.

1 Georgia State University, Atlanta, GA, USA.

Background: Emotions are important in smoking-related communications, but the role of discrete positive and negative emotions in comparative risk messages about combusted and electronic cigarettes (e-cigarettes) is unclear.

Method: In an online experiment, 1,202 U.S. Read More

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http://dx.doi.org/10.1177/1090198118825236DOI Listing
February 2019

Barriers and facilitators to switching from smoking to vaping: Advice from vapers.

Drug Alcohol Rev 2019 Feb 10. Epub 2019 Feb 10.

Faculty of Medicine, School of Public Health, The University of Queensland, Brisbane, Australia.

Introduction And Aims: Information available to consumers about nicotine vaping products varies according to the regulatory environment. A common information source in Australia, where nicotine vaping products are highly regulated, is advice from vapers. The aim of this study was to report on what advice current vapers would give to someone new to vaping. Read More

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http://dx.doi.org/10.1111/dar.12907DOI Listing
February 2019

Epigenetic down-regulation of BK channel by miR-181a contributes to the fetal and neonatal nicotine-mediated exaggerated coronary vascular tone in adult life.

Int J Cardiol 2019 Jan 31. Epub 2019 Jan 31.

Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address:

Background: Fetal origin of adult cardiovascular disease is one of the most pressing public concerns and economic problem in modern life. Maternal cigarette smoking/nicotine abuse increases the risk of cardiovascular disease in offspring. However, the underlying mechanisms and theranostics remain unclear. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.099DOI Listing
January 2019

Re: Disregarding the impact of nicotine on the developing brain when evaluating costs and benefits of noncombustible nicotine products.

Prev Med 2019 Mar;120:158-159

Department of Social and Behavioral Sciences, NYU College of Global Public Health, New York University, New York, NY, United States of America.

This Letter to the Editor is in response to a letter from Ms. Flannery, titled, "Disregarding the impact of nicotine on the developing brain when evaluating costs and benefits of noncombustible nicotine products". In our response, we address some concerns raised by Ms. Read More

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http://dx.doi.org/10.1016/j.ypmed.2018.12.027DOI Listing

Disregarding the impact of nicotine on the developing brain when evaluating costs and benefits of noncombustible nicotine products.

Prev Med 2019 Mar;120:157

Department of Psychology, Florida International University, 11200 S.W. 8th Street, Miami, FL 33199, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ypmed.2018.11.023DOI Listing

Genetic variants as risk factors for cigarette smoking at an early age and relapse to smoking cessation treatment: A pilot study.

Gene 2019 Feb 6;694:93-96. Epub 2019 Feb 6.

HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico. Electronic address:

Objectives: Tobacco smoking is a complex and multifactorial disease involving both environmental and genetic factors. In the Mexican mestizo population, single-nucleotide polymorphisms (SNPs) associated with cigarette smoking and a greater degree of nicotine addiction have been identified; however, no possible roles have been explored in regard to the age of onset of smoking or in the success of quitting.

Methods: In this study, 151 Mexican mestizo, who smoke cigarettes, were included. Read More

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http://dx.doi.org/10.1016/j.gene.2019.01.036DOI Listing
February 2019
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Discriminative stimulus effects of mecamylamine and nicotine in rhesus monkeys: Central and peripheral mechanisms.

Pharmacol Biochem Behav 2019 Feb 6;179:27-33. Epub 2019 Feb 6.

Department of Pharmacodynamics, The University of Florida, Gainesville, FL, USA. Electronic address:

Mecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacological mechanisms underlying the interoceptive effects (i.e. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.002DOI Listing
February 2019