3,182,591 results match your criteria New Zealand Optics [Journal]


Case-Control Retrospective Study of Child Sexual Abuse History among Psychiatric Consultations in a General Hospital Emergency Room.

Isr Med Assoc J 2019 Feb;21(2):77-81

Department of Consultation and Liaison Psychiatry, Shaare Zedek Medical Center, Jerusalem, Israel.

Background: A history of childhood sexual abuse (CSA) has been linked to a variety of physical and psychiatric illnesses, including ischemic heart disease and post-traumatic stress disorder (PTSD).

Objectives: To determine the prevalence of past CSA and re-traumatization among hospital psychiatric consultations and to determine whether a CSA group in a hospital setting shared characteristics with community samples described in the literature.

Methods: We divided 228 consecutive psychiatric consultations into two groups. Read More

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February 2019

Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post-menopausal women with severe pelvic organ prolapse.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Physiology, University of Toronto, Toronto, ON, Canada.

This study investigates the effect of local oestrogen therapy (LET) on the expression of proteins participating in collagen/elastin biogenesis and immune markers in vaginal tissues of post-menopausal women with severe pelvic organ prolapse (POP). Vaginal biopsies were collected from the anterior vaginal wall of informed and consented 52 post-menopausal women with severe POP undergoing total hysterectomy. Twenty-nine of the 52 women were treated with LET (in the form of vaginal oestrogen cream or tablet), while the remaining 23 untreated patients served as the controls. Read More

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http://dx.doi.org/10.1111/jcmm.14199DOI Listing
February 2019

Iodine status of Indigenous and non-Indigenous young adults in the Top End, before and after mandatory fortification.

Med J Aust 2019 Feb 7;210(3):121-125. Epub 2018 Dec 7.

Food Standards Australia New Zealand, Canberra, ACT.

Objective: To assess the median urine iodine concentration (UIC) of young adults in the Top End of Northern Territory, before and after fortification of bread with iodised salt became mandatory.

Design, Setting: Analysis of cross-sectional data from two longitudinal studies, the Aboriginal Birth Cohort and the non-Indigenous Top End Cohort, pre- (Indigenous participants: 2006-2007; non-Indigenous participants: 2007-2009) and post-fortification (2013-15).

Participants: Indigenous and non-Indigenous Australian young adults (mean age: pre-fortification, 17. Read More

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http://dx.doi.org/10.5694/mja2.12031DOI Listing
February 2019

Exposures to e-cigarettes and their refills: calls to Australian Poisons Information Centres, 2009-2016.

Med J Aust 2019 Feb 12;210(3):126. Epub 2018 Nov 12.

Victorian Poisons Information Centre, Austin Health, Melbourne, VIC.

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http://dx.doi.org/10.5694/mja2.12032DOI Listing
February 2019

Dynamic Piston Function of the Mitral Annulus to Assess Early Left Ventricular Diastolic Filling: A Proof of Concept Study.

Cardiol Ther 2019 Feb 16. Epub 2019 Feb 16.

Cardiovascular Medicine Division, University of Puerto Rico School of Medicine, San Juan, PR, USA.

Introduction: Early left ventricular (LV) filling has been described as an asymmetric toroidal vortex ring of blood entering the LV upon opening of the mitral valve. This phenomenon is in part responsible for cyclical changes in LV volumes during the cardiac cycle and also contributes to the apical and basal longitudinal displacements of the mitral annulus (MA). Although MA early diastolic (e') velocities have been used to assess early LV filling characteristics, accurate distinction between normal aging and pathological diastolic dysfunction (DD) might be challenging at times. Read More

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http://dx.doi.org/10.1007/s40119-019-0130-9DOI Listing
February 2019

Feeding the world: improving photosynthetic efficiency for sustainable crop production.

J Exp Bot 2019 Feb 16. Epub 2019 Feb 16.

School of Biological Sciences, Wivenhoe Park, University of Essex, Colchester, UK.

A number of recent studies have provided strong support demonstrating that improving the photosynthetic processes through genetic engineering can provide an avenue to improve yield potential. The major focus of this review is on improvement of the Calvin-Benson cycle and electron transport. Consideration is also given to how altering regulatory process may provide an additional route to increase photosynthetic efficiency. Read More

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http://dx.doi.org/10.1093/jxb/ery445DOI Listing
February 2019

Breakthroughs and new horizons in reproductive biology of rare and endangered animal species.

Biol Reprod 2019 Feb 17. Epub 2019 Feb 17.

Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield S10 2SF, UK.

Because of higher extinction rates due to human and natural factors, more basic and applied research in reproductive biology is required to preserve wild species and design proper strategies leading to sustainable populations. The objective of the review is to highlight recent, inspiring breakthroughs in wildlife reproduction science that will set directions for future research and lead to more successes in conservation biology. Despite new tools and approaches allowing a better and faster understanding of key mechanisms, we still know little about reproduction in endangered species. Read More

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http://dx.doi.org/10.1093/biolre/ioz031DOI Listing
February 2019

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial.

JAMA 2019 Feb 17. Epub 2019 Feb 17.

Departmento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago.

Importance: Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established.

Objective: To determine if a peripheral perfusion-targeted resuscitation during early septic shock in adults is more effective than a lactate level-targeted resuscitation for reducing mortality. Read More

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http://dx.doi.org/10.1001/jama.2019.0071DOI Listing
February 2019

Patterns of high-risk prescribing and other factors in relation to receipt of a home medicines review: a prospective cohort investigation among adults aged 45 years and over in Australia.

BMJ Open 2019 Feb 15;9(2):e027305. Epub 2019 Feb 15.

Research School of Population Health, Australian National University, Canberra, Sydney, Australia.

Objectives: To quantify the relationship between home medicines review (HMR) receipt in older adults and sociodemographic, medication-related and health factors.

Design: Prospective cohort analysis.

Settings, Participants, Measurements: Questionnaire data from a population-based cohort study of individuals aged ≥45 years, Sydney, Australia were linked with primary healthcare data, medication and hospitalisation data, to ascertain factors associated with HMR receipt during the period July 2009-June 2014. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027305DOI Listing
February 2019

Defining compassion in the digital health age: protocol for a scoping review.

BMJ Open 2019 Feb 15;9(2):e026338. Epub 2019 Feb 15.

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Introduction: The notion of compassion and compassionate care is playing an increasingly important role in health professional education and in the delivery of high-quality healthcare. Digital contexts, however, are not considered in the conceptualisation of compassionate care, nor is there guidance on how compassionate care is to be exercised while using digital health technologies. The widespread diffusion of digital health technologies provides new contexts for compassionate care, with both opportunities for new forms and instantiations of compassion as well as new challenges. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026338DOI Listing
February 2019

VaccHemInf project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients.

BMJ Open 2019 Feb 15;9(2):e026093. Epub 2019 Feb 15.

Département des Maladies Infectieuses et Tropicales, Hospices Civils de Lyon, Lyon, France.

Introduction: Immune reconstitution after haematopoietic stem cell transplantation (HSCT) is a complex and dynamic process, varying from a state of nearly complete immunosuppression to an expected full immune recovery. Specific vaccination guidelines recommend reimmunisation after HSCT but data regarding vaccine efficacy in this unique population are scarce. New immune functional assays could enable prediction of vaccine response in the setting of HSCT. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026093DOI Listing
February 2019

Paramedics' experiences of administering fascia iliaca compartment block to patients in South Wales with suspected hip fracture at the scene of injury: results of focus groups.

BMJ Open 2019 Feb 15;9(2):e026073. Epub 2019 Feb 15.

Medical School, Swansea University, Swansea, UK.

Objectives: To explore paramedics' experience of delivering fascia iliaca compartment block FICB) to patients with suspected hip fracture at the scene of injury.

Design: Focus groups within a randomised controlled trial.

Setting: Paramedics based at ambulance stations in the catchment area of one Emergency Department in South Wales, recruited and trained in a feasibility study about an alternative to routine prehospital pain management for patients with suspected hip fracture. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026073DOI Listing
February 2019

Lung Cancer App (LuCApp) study protocol: a randomised controlled trial to evaluate a mobile supportive care app for patients with metastatic lung cancer.

BMJ Open 2019 Feb 15;9(2):e025483. Epub 2019 Feb 15.

Centre for Research in Health and Social Care Management (CERGAS), SDA Bocconi, Milano, Italy.

Introduction: Mobile health technologies may enhance patient empowerment and data integration along the whole care continuum. However, these interventions pose relatively new regulatory, organisational and technological challenges that limit appropriate evaluation. Lung Cancer App (LuCApp) is a mobile application developed by researchers and clinicians to promote real-time monitoring and management of patients' symptoms. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025483DOI Listing
February 2019

Using specialist screening practitioners (SSPs) to increase uptake of bowel scope (flexible sigmoidoscopy) screening: results of a feasibility single-stage phase II randomised trial.

BMJ Open 2019 Feb 15;9(2):e023801. Epub 2019 Feb 15.

Research Department of Behavioural Science and Health, University College London, London, UK.

Objective: To determine the feasibility of specialist screening practitioners (SSPs) offering patient navigation (PN) to facilitate uptake of bowel scope screening (BSS) among patients who do not confirm or attend their appointment.

Design: A single-stage phase II trial.

Setting: South Tyneside District Hospital, Tyne and Wear, England, UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023801DOI Listing
February 2019

Does One Health require a novel ethical framework?

J Med Ethics 2019 Feb 16. Epub 2019 Feb 16.

Australian Centre for Health Engagement, Evidence and Values, University of Wollongong, Wollongong, New South Wales, Australia.

Emerging infectious diseases (EIDs) remain a significant and dynamic threat to the health of individuals and the well-being of communities across the globe. Over the last decade, in response to these threats, increasing scientific consensus has mobilised in support of a One Health (OH) approach so that OH is now widely regarded as the most effective way of addressing EID outbreaks and risks. Given the scientific focus on OH, there is growing interest in the philosophical and ethical dimensions of this approach, and a nascent OH literature is developing in the humanities. Read More

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http://dx.doi.org/10.1136/medethics-2018-105043DOI Listing
February 2019

Spinal epidural lipomatosis following bilateral spinal decompression surgery.

BMJ Case Rep 2019 Feb 15;12(2). Epub 2019 Feb 15.

North Bristol NHS Trust, Bristol, UK.

A 73-year-old man underwent bilateral spinal decompression of L4/5 for severe spinal canal stenosis, requiring minimal analgesia and providing immediate relief. Two days post-operatively, he presented with new onset bilateral leg pain and difficulty mobilising. MRI demonstrated spinal epidural lipomatosis (SEL), which was not present pre-operatively, at L5/S1. Read More

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http://dx.doi.org/10.1136/bcr-2018-226985DOI Listing
February 2019

Categorising characteristics of counterfeit Marlboro cigarettes: a systematic review of tobacco industry documents.

Tob Control 2019 Feb 16. Epub 2019 Feb 16.

Center for Tobacco Studies, Rutgers School of Public Health, New Brunswick, New Jersey, USA.

Background: There is scant research on methods used to identify counterfeit Marlboro cigarettes.

Methods: Systematic analysis of internal tobacco industry documents characteristics of counterfeit Marlboro cigarettes.

Results: In the industry documents we identified as relevant, there were 42 characteristics of counterfeit Marlboro cigarettes. Read More

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http://dx.doi.org/10.1136/tobaccocontrol-2018-054743DOI Listing
February 2019

Twelve-month analgesia and rescue, by cooled radiofrequency ablation treatment of osteoarthritic knee pain: results from a prospective, multicenter, randomized, cross-over trial.

Reg Anesth Pain Med 2019 Feb 16. Epub 2019 Feb 16.

Center for Clinical Research, Winston Salem, North Carolina, USA

Background And Objectives: As a follow-up to the 6-month report,12 this study investigated the analgesic effect of cooled radiofrequency ablation (CRFA) in patients with knee osteoarthritis (OA) 12 months postintervention and its ability to provide pain relief in patients who experienced unsatisfactory effects of intra-articular steroid injection (IAS).

Methods: Seventy-eight per cent (52/67) of patients originally treated with CRFA were evaluated at 12 months, while at 6 months post-IAS, 82% (58/71) of those patients crossed over to CRFA and assessed 6 months later.

Results: At 12 months, 65% of the original CRFA group had pain reduction ≥50%, and the mean overall drop was 4. Read More

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http://dx.doi.org/10.1136/rapm-2018-100051DOI Listing
February 2019

Metal-based biologically active compounds: Synthesis, spectral and antioxidant studies of transition metal complexes with hydrazone derivatives.

Pak J Pharm Sci 2019 Jan;32(1):103-108

Department of Chemistry, University of Karachi, Karachi, Pakistan.

New series of Co+2, Ni+2, Cu+2 and Zn+2 complexes have been synthesized using a bio-active hydrazone compound 4-hydroxybenzaldehyde-N-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene), abbreviated as [HL]. Complexes were characterized using elemental analysis, FT-IR, UV-visible spectroscopy conductivity and magnetic susceptibility measurements. Results showed that the bi-dentate [HL] coordinated in a square planner manner with Cu while for the rest of the M ions, it coordinated in a octahedral fashion. Read More

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January 2019

Synthesis of some new N-(alkyl/aralkyl)-N-(2,3-dihydro-1,4-benzodioxan-6-yl)-4-chlorobenzenesulfonamides as possible therapeutic agents for Alzheimer's disease and Type-2 Diabetes.

Pak J Pharm Sci 2019 Jan;32(1):61-68

Department of Soil Sciences, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

In the current research work, a series of new N-(alkyl/aralkyl)-N-(2,3-dihydro-1,4-benzodioxan-6-yl)-4-chlorobenzenesulfonamides has been synthesized by reacting 1,4-benzozzdioxan-6-amine (1) with 4-chlorobenzenesulfonyl chloride (2) to yield N-(2,3-dihydro-1,4-benzodioxan-6-yl)-4-chlorobenzenesulfonamide (3) which was further reacted with different alkyl/aralkyl halides (4a-n) to afford the target compounds (5a-n). Structures of the synthesized compounds were confirmed by IR, 1H-NMR, EI-MS spectral techniques and CHN analysis data. The results of enzyme inhibition showed that the molecules, N-2-phenethyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-chlorobenzenesulfonamide (5j) and N-(1-butyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-chlorobenzenesulfonamide (5d), exhibited moderate inhibitory potential against acetylcholinesterase with IC50 values 26. Read More

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January 2019

Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents.

Pak J Pharm Sci 2019 Jan;32(1):15-19

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

This research based on the anti-inflammatory and antiplatelet aggregation properties of some new thiazolyl hydrazone derivatives of 1-indanone. In this regard a thiosemicabazone and twelve thiazolyl derivatives of 1-indanone have been synthesized. Out of these synthetic compounds seven derivatives 1-3, 6, 11-13 exhibited varying degree of anti-inflammatory action with IC esteems going from 5. Read More

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January 2019

Total flavone of Abelmoschl manihot L. medic exhibits protective effect against hind-limb ischemia in rat model.

Pak J Pharm Sci 2019 Jan;32(1):1-5

Department of Cardiovascular Medicine, Jiangsu Province Hospital of Traditional Chinese Medicine, The No.1 Clinical Medical College of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China.

Total flavones of Abelmoschus manihot L. Medic (TFA) is the major active component isolated from Chinese herb Abelmoschus manihot L. Medic. Read More

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January 2019

Synthetic cannabinoid use among college students.

Addict Behav 2019 Feb 11;93:219-224. Epub 2019 Feb 11.

Psychiatry Residency Program, Louisiana State University Health Sciences Center, Baton Rouge, LA, United States; Louisiana State University, Department of Psychology, Baton Rouge, LA, United States.

Background And Objectives: Synthetic cannabinoid use is associated with severe problems, including psychosis, kidney failure, and death. Given that young adults are especially vulnerable to using synthetic cannabinoids, the current study sought to identify factors and consequences related to use within this population.

Methods: 1140 undergraduates completed an online survey of synthetic cannabinoid use, consequences, and related constructs. Read More

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http://dx.doi.org/10.1016/j.addbeh.2019.02.009DOI Listing
February 2019

Alpha-cyclodextrin inhibits cholesterol crystal-induced complement-mediated inflammation: A potential new compound for treatment of atherosclerosis.

Atherosclerosis 2019 Feb 3;283:35-42. Epub 2019 Feb 3.

Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Faculty of Health and Medical Sciences, Rigshospitalet, University of Copenhagen, Denmark. Electronic address:

Background And Aims: Cholesterol crystal (CC)-induced inflammation is a critical step in the development of atherosclerosis. CCs activate the complement system and induce an inflammatory response resulting in phagocytosis of the CCs, production of reactive oxygen species (ROS) and release of cytokines. The cyclodextrin 2-hydroxypropyl-β-cyclodextrin has been found to reduce CC-induced complement activation and induce regression of established atherosclerotic plaques in a mouse model of atherosclerosis, thus inhibition of complement with cyclodextrins is a potential new strategy for treatment of inflammation during atherosclerosis. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.034DOI Listing
February 2019

Macroporous hydrogels derived from aqueous dynamic phase separation.

Biomaterials 2019 Feb 2;200:56-65. Epub 2019 Feb 2.

Tissue Engineering and Biofabrication Laboratory, Department of Health Sciences and Technology, ETH Zürich, Otto-Stern-Weg 7, 8093, Zürich, Switzerland. Electronic address:

A method to generate injectable macroporous hydrogels based on partitioning of polyethylene glycol (PEG) and high viscous polysaccharides is presented. Step growth polymerization of PEG was used to initiate a phase separation and the formation of a connected macroporous network with tunable dimensions. The possibilities and physical properties of this new category of materials were examined, and then applied to address some challenges in neural engineering. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.047DOI Listing
February 2019

Effects of illness duration on cognitive performances in bipolar depression are mediated by white matter microstructure.

J Affect Disord 2019 Feb 8;249:175-182. Epub 2019 Feb 8.

University Vita-Salute San Raffaele, Milano, Italy.

Background: Cognitive deficits are a core feature of bipolar disorder (BD), and persist during the euthymic phase. White matter (WM) microstructural abnormalities are widely considered a structural marker of BD. Features of illness chronicity, such as illness duration and number of mood episodes, have been associated with worsening of both clinical profile and brain structural alterations. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.015DOI Listing
February 2019

Importance of sperm density in assessing the toxicity of metals to the fertilization of broadcast spawners.

Ecotoxicol Environ Saf 2019 Feb 14;172:547-555. Epub 2019 Feb 14.

Faculty of Engineering Sciences, University College London, GPO Box 2471, Adelaide SA 5001, Australia.

Many marine invertebrates reproduce through broadcast spawning, where sperm and eggs are released into the water column and are vulnerable to toxicants present in the environment. The potential impacts of toxicants on spawning success are often assessed through laboratory-based fertilization tests. In most cases, these tests assess toxicant impacts at a single, pre-defined sperm density, based on a sperm:egg ratio that ensures high fertilization success (≥70-80%) in a filtered seawater control. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.053DOI Listing
February 2019

Transdermal buprenorphine patch: Potential for role in management of opioid dependence.

Asian J Psychiatr 2019 Feb 10;40:88-91. Epub 2019 Feb 10.

All India Institute for Medical Sciences, New Delhi, 110029, India.

Despite proven clinical utility, use of sublinugual buprenorphine is fraught with issues of potential diversion among patients with opioid dependence. Transdermal buprenorphine patches provide an alternative delivery model that can be utilized to reduce such diversion. This narrative review discusses the transdermal buprenorphine formulations, and its pharmacology, drug interaction and tolerability profile. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.002DOI Listing
February 2019

Abating N in Nordic agriculture - Policy, measures and way forward.

J Environ Manage 2019 Feb 14;236:674-686. Epub 2019 Feb 14.

Natural Resources Institute Finland (Luke), Tietotie 4, FI-31600, Jokioinen, Finland.

During the past twenty years, the Nordic countries (Denmark, Sweden, Finland and Norway) have introduced a range of measures to reduce losses of nitrogen (N) to air and to aquatic environment by leaching and runoff. However, the agricultural sector is still an important N source to the environment, and projections indicate relatively small emission reductions in the coming years. The four Nordic countries have different priorities and strategies regarding agricultural N flows and mitigation measures, and therefore they are facing different challenges and barriers. Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.11.143DOI Listing
February 2019

An examination of attributes and barriers to adopt biomass and solar technology. A cross-cultural approach.

J Environ Manage 2019 Feb 14;236:639-648. Epub 2019 Feb 14.

Department Marketing and Market Research. Faculty of Business and Economics. University of Granada, Spain. Electronic address:

This research is primarily aimed at analyzing the most favorable and unfavorable characteristics considered by consumers contemplating the adoption of biomass and solar energy technologies. The pro-environmental behavior, the level of anthropocentrism and ecocentrism in three different cultures are also analyzed using the New Ecological Paradigm scale. Based on a sample of 489 respondents collected by questionnaire, it finds the predominant view in the three cultures is ecocentrism. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.02.022DOI Listing
February 2019

Structural brain network measures are superior to vascular burden scores in predicting early cognitive impairment in post stroke patients with small vessel disease.

Neuroimage Clin 2019 Feb 5;22:101712. Epub 2019 Feb 5.

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.

Objectives: In this cross-sectional study, we aimed to explore the mechanisms of early cognitive impairment in a post stroke non-dementia cerebral small vessel disease (SVD) cohort by comparing the SVD score with the structural brain network measures.

Method: 127 SVD patients were recruited consecutively from a stroke clinic, comprising 76 individuals with mild cognitive impairment (MCI) and 51 with no cognitive impairment (NCI). Detailed neuropsychological assessments and multimodal MRI were performed. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101712DOI Listing
February 2019

Safety and Feasibility of Robotic Distal Gastrectomy for Stage IA Gastric Cancer: A Phase II Trial.

J Surg Res 2019 Feb 14;238:224-231. Epub 2019 Feb 14.

Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan; Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan.

Background: Conventional laparoscopic and open distal gastrectomy procedures have inherent limitations such as restricted movement of straight forceps and tremor of the tip of the devices that can potentially be overcome using robotic distal gastrectomy (RDG). This single-institutional phase II trial aimed to evaluate the safety and feasibility of RDG with lymph node dissection for clinical stage IA gastric cancer.

Methods: The study included patients with clinical stage IA gastric cancer in the lower two-thirds of the stomach considered to be curatively resected via distal gastrectomy. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.049DOI Listing
February 2019

PEO-b-PCL grafted niosomes: The cooperativilty of amphiphilic components and their properties in vitro and in vivo.

Colloids Surf B Biointerfaces 2019 Jan 22;177:338-345. Epub 2019 Jan 22.

Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.

Niosomes belong to drug delivery systems and consist mainly of non-ionic surfactants and cholesterol. In this study, we designed and developed systems composed of non-ionic surfactants i.e. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.036DOI Listing
January 2019

Effect of γ-oryzanol on testicular degeneration induced by scrotal insulation in rams.

Theriogenology 2019 Feb 7;128:167-175. Epub 2019 Feb 7.

Laboratório de Biotecnologia da Reprodução (Biotech), Campus Uruguaiana, Universidade Federal do Pampa, CEP 97500-970, Uruguaiana, RS, Brazil. Electronic address:

The present study assessed the effects of daily supplementation with 33 mg/metabolic weight (MW) of γ-oryzanol on testicular degeneration induced by scrotal insulation in rams. Eight animals were divided into two groups: Control (subjected to scrotal insulation without treatment) and Gamma (subjected to scrotal insulation and γ-oryzanol treatment). The rams were subjected to scrotal insulation by covering the scrotum with a thermal bag for 72 h. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.041DOI Listing
February 2019

Major seminal plasma proteome of rabbits and associations with sperm quality.

Theriogenology 2019 Feb 7;128:156-166. Epub 2019 Feb 7.

Department of Animal Science, Federal University of Ceará, Fortaleza, CE, Brazil. Electronic address:

The present study was conducted to describe the major seminal plasma proteome of rabbits and potential associations between seminal proteins and semen criteria. Semen samples were collected from 18 New Zealand adult rabbits, and seminal plasma proteins were analyzed by 2-D SDS-PAGE and tandem mass spectrometry. Sperm motility, vigor, concentration, morphology and membrane sperm viability were evaluated. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.013DOI Listing
February 2019

"LA Plus"- a laryngeal mask airway with an in-built endotracheal tube.

J Clin Anesth 2019 Feb 14;56:126-127. Epub 2019 Feb 14.

Department of Anesthesiology, Albany Medical Center, 43, New Scotland Avenue, Albany, NY 12208, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2019.01.048DOI Listing
February 2019

ACCELERATE and European Medicine Agency Paediatric Strategy Forum for medicinal product development for mature B-cell malignancies in children.

Eur J Cancer 2019 Feb 14;110:74-85. Epub 2019 Feb 14.

Department of Clinical Research, Gustave Roussy, Paris-Sud University, Paris, France.

Paediatric Strategy Forums have been created by the multistakeholder organisation, ACCELERATE, and the European Medicines Agency to facilitate dialogue between all relevant stakeholders and suggest strategies in critical areas of paediatric oncology drug development. As there are many medicines being developed for B-cell malignancies in adults but comparatively few in children with these malignancies, a Paediatric Strategy Forum was held to discuss the best approach to develop these products for children. It was concluded that as current frontline therapy is highly successful, despite associated acute toxicity, de-escalation of this or substitution of presently used drugs with new medicines can only be undertaken when there is an effective salvage regimen, which is currently not available. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.013DOI Listing
February 2019

Prostatic ductal adenocarcinoma with cribriform architecture has worse prognostic features than non-cribriform-type.

Ann Diagn Pathol 2019 Feb 10;39:59-62. Epub 2019 Feb 10.

Department of Pathology and Laboratory Medicine, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

Prostatic ductal adenocarcinoma (PDA) is a rare histologic subtype of prostate cancer characterized by large glands lined with tall columnar pseudostratified epithelium. PDA has several architectural patterns, with papillary and cribriform being the most common. The cribriform pattern of acinar carcinoma has shown to be associated with a worse prognosis in terms of disease progression and disease-specific mortality. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.007DOI Listing
February 2019

Similarity is as similarity does? A critical inquiry into the effect of thematic association on similarity.

Cognition 2019 Feb 14;186:115-138. Epub 2019 Feb 14.

Binghamton University (SUNY), United States.

Leading theories of psychological similarity are based on the degree of match in semantic content between compared cases (i.e., shared features, low dimensional distance, alignable relations). Read More

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http://dx.doi.org/10.1016/j.cognition.2019.01.016DOI Listing
February 2019

Synthesis, crystal structure and biological evaluation of new phosphoramide derivatives as urease inhibitors using docking, QSAR and kinetic studies.

Bioorg Chem 2019 Feb 8;86:482-493. Epub 2019 Feb 8.

Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran.

In an attempt to achieve a new class of phosphoramide inhibitors with high potency and resistance to the hydrolysis process against urease enzyme, we synthesized a series of bisphosphoramide derivatives (01-43) and characterized them by various spectroscopic techniques. The crystal structures of compounds 22 and 26 were investigated using X-ray crystallography. The inhibitory activities of the compounds were evaluated against the jack bean urease and were compared to monophosphoramide derivatives and other known standard inhibitors. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.01.064DOI Listing
February 2019

Development of sugarcane resource for efficient fermentation of exopolysaccharide by using a novel strain of Kosakonia cowanii LT-1.

Bioresour Technol 2019 Feb 11;280:247-254. Epub 2019 Feb 11.

WuXi AppTec (Suzhou) Testing Technology Co. Ltd, 1336 Wuzhong Avenue, Suzhou 215104, China.

This work focuses on the development of non-food fermentation for the cost-effective biosynthesis of exopolysaccharide (EPS) by using a new strain of Kosakonia cowanii LT-1. This novel strain more efficiently utilizes sucrose for EPS production than other glycosyl donors. Comparative transcriptomic analysis is used to understand EPS synthesis promotion and the effects of sucrose on EPS biosynthesis. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.053DOI Listing
February 2019

The peculiar aging of human liver: A geroscience perspective within transplant context.

Ageing Res Rev 2019 Feb 14. Epub 2019 Feb 14.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; CIG-Interdepartmental Center "Galvani", University of Bologna, Bologna, Italy; CSR-Centro di Studio per la Ricerca dell'Invecchiamento, University of Bologna, Bologna, Italy.

An appraisal of recent data highlighting aspects inspired by the new Geroscience perspective are here discussed. The main findings are summarized as follows: i) liver has to be considered an immunological organ, and new studies suggest a role for the recently described cells named telocytes; ii) the liver-gut axis represents a crucial connection with environment and life style habits and may influence liver diseases onset; iii) the physiological aging of liver shows relatively modest alterations. Nevertheless, several molecular changes appear to be relevant: a) an increase of microRNA-31-5p; -141-3p; -200c-3p expressions after 60 years of age; b) a remodeling of genome-wide DNA methylation profile evident until 60 years of age and then plateauing; c) changes in transcriptome including the metabolic zones of hepatocyte lobules; d) liver undergoes an accelerated aging in presence of chronic inflammation/liver diseases in a sort of continuum, largely as a consequence of unhealthy life styles and exposure to environmental noxious agents. Read More

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http://dx.doi.org/10.1016/j.arr.2019.02.002DOI Listing
February 2019

Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.

Eur J Med Chem 2019 Feb 7;167:226-244. Epub 2019 Feb 7.

Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India; Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India. Electronic address:

A series of new pyranocarbazole derivatives were synthesized via semi-synthetic modification of koenimbine (1a) and koenidine (1b) isolated from the leaves of Murraya koenigii. Among all, compound 3bg displayed significant anti-cancer activity against MDA-MB-231, DU145 and PC3 cell lines with the IC values of 3.8, 7. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.003DOI Listing
February 2019

2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors.

Eur J Med Chem 2019 Feb 10;167:200-210. Epub 2019 Feb 10.

Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy. Electronic address:

A class of 36 new 2-(6-phenylimidazo[2,-1-b][1,3,4]thiadiazol-2-yl)-1H-indoles was efficiently synthesized and evaluated for their anti-biofilm properties against the Gram-positive bacterial reference strains Staphylococcus aureus ATCC 25923, S. aureus ATCC 6538 and Staphylococcus epidermidis ATCC 12228, and the Gram-negative strains Pseudomonas aeruginosa ATCC 15442 and Escherichia coli ATCC 25922. Many of these new compounds, were able to inhibit biofilm formation of the tested staphylococcal strains showing BIC lower than 10 μg/ml. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.007DOI Listing
February 2019
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Rickets severity predicts clinical outcomes in children with X-linked hypophosphatemia: Utility of the radiographic Rickets Severity Score.

Bone 2019 Feb 14. Epub 2019 Feb 14.

Yale University School of Medicine, New Haven, CT, USA.

The Rickets Severity Score (RSS) was used to evaluate X-linked hypophosphatemic rickets (XLH), a genetic disorder mediated by increased circulating FGF23. The reliability of the RSS was assessed using data from a randomized, phase 2 clinical trial that evaluated the effects of burosumab, a fully human anti-FGF23 monoclonal antibody, in 52 children with XLH ages 5 to 12 years. Bilateral knee and wrist radiographs were obtained at baseline, week 40, and week 64. Read More

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http://dx.doi.org/10.1016/j.bone.2019.02.010DOI Listing
February 2019

Prediction and identification of discrete-time dynamic nonlinear systems based on adaptive echo state network.

Neural Netw 2019 Feb 1;113:11-19. Epub 2019 Feb 1.

College of Information Science and Engineering, Northeastern University, Shenyang, 110819, China.

In this paper, a new prediction and identification method based on adaptive echo state network (AESN) is proposed to identify a class of discrete-time dynamic nonlinear systems (DDNS). Firstly, according to the characteristics of input signals, the reservoir state update equation of AESN can be adaptively adjusted. In order to guarantee the echo state property of AESN, a sufficient condition for echo state property is given. Read More

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http://dx.doi.org/10.1016/j.neunet.2019.01.003DOI Listing
February 2019

Fixed-time synchronization of quaternion-valued memristive neural networks with time delays.

Authors:
Ruoyu Wei Jinde Cao

Neural Netw 2019 Feb 1;113:1-10. Epub 2019 Feb 1.

School of Mathematics, and Research Center for Complex Systems and Network Sciences, Southeast University, Nanjing 210996, Jiangsu, China. Electronic address:

In this paper, a new type of neural networks, quaternion-valued memristive neural networks (QVMNNs) is formulated. On the basis of the differential inclusion principle and the Lyapunov functional method, fixed-time synchronization problem is considered in the form of drive-response system for this type of neural networks. A novel fixed-time controller is designed to achieve the control goal. Read More

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http://dx.doi.org/10.1016/j.neunet.2019.01.014DOI Listing
February 2019

Potential effects of suspended TiO nanoparticles on activated sludge floc properties in membrane bioreactors.

Chemosphere 2019 Feb 11;223:148-156. Epub 2019 Feb 11.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, 200092, China. Electronic address:

With the rapid development and application of consumer products containing nanoparticles (NPs), especially titanium dioxide (TiO) NPs, the potential effects of suspended NPs on wastewater treatment has been a concern over the recent years. This study investigated the potential effects of suspended TiO NPs on activated sludge flocculation properties in a membrane bioreactor (MBR). Results showed that suspended TiO NPs inhibited the viability of activated sludge flocs, and led to bacterial protein secretion for bacterial protection, causing an overall protein increase of soluble microbial products. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.042DOI Listing
February 2019

Managing risks and future options from new lakes in the deglaciating Andes of Peru: The example of the Vilcanota-Urubamba basin.

Sci Total Environ 2019 Feb 6;665:465-483. Epub 2019 Feb 6.

Department of Geography, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland.

Rapidly growing lakes in deglaciating mountain regions represent both: emerging risks and options for human livelihoods. In the Andes of Peru, seasonal water scarcity and Glacial Lake Outburst Floods (GLOF) pose a serious threat for highly exposed and vulnerable people. In addition, water demand is growing due to increasing irrigated agriculture, population and hydropower production. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.070DOI Listing
February 2019
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