3,223,490 results match your criteria New Zealand Optics [Journal]


Detecting Early Pancreatic Cancer: Current Problems and Future Prospects.

Gut Liver 2019 Apr 23. Epub 2019 Apr 23.

Divisions of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18491DOI Listing
April 2019
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Postnatal Development of Mice with Combined Genetic Depletions of Lamin A/C, Emerin and Lamina-associated Polypeptide 1.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine.

Mutations in LMNA encoding lamin A/C and EMD encoding emerin cause cardiomyopathy and muscular dystrophy. Lmna null mice develop these disorders and have a lifespan of 7-8 weeks. Emd null mice show no overt pathology and have normal skeletal muscle but with regeneration defects. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/hmg/ddz082DOI Listing
April 2019
1 Read

National Institutes of Health Pathways to Prevention Workshop: Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

University of South Carolina, Arnold School of Public Health, Columbia, South Carolina (M.L.).

On 30 and 31 October 2018, the National Institutes of Health convened the Pathways to Prevention (P2P) Workshop: Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention to assess the available evidence on long-term (>3 years) use of drug therapies to prevent osteoporotic fractures and identify research gaps and needs for advancing the field. The workshop was cosponsored by the NIH Office of Disease Prevention (ODP), National Institute of Arthritis and Musculoskeletal and Skin Diseases, and National Institute on Aging. A multidisciplinary working group developed the agenda, and an Evidence-based Practice Center prepared an evidence report through a contract with the Agency for Healthcare Research and Quality to facilitate the discussion. Read More

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http://dx.doi.org/10.7326/M19-0961DOI Listing

Maternal Glycemic Control in Type 1 Diabetes and the Risk for Preterm Birth: A Population-Based Cohort Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Karolinska Institutet, Stockholm, Sweden, and Statens Serum Institut, Copenhagen, Denmark (B.P.).

Background: Maternal type 1 diabetes (T1D) has been linked to preterm birth and other adverse pregnancy outcomes. How these risks vary with glycated hemoglobin (or hemoglobin A1c [HbA1c]) levels is unclear.

Objective: To examine preterm birth risk according to periconceptional HbA1c levels in women with T1D. Read More

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http://dx.doi.org/10.7326/M18-1974DOI Listing

Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana (J.W.A., K.M.G.).

Background: Identifying reliable predictors of long-term weight loss (LTWL) could lead to improved weight management.

Objective: To identify some predictors of LTWL.

Design: The DPP (Diabetes Prevention Program) was a randomized controlled trial that compared weight loss with metformin, intensive lifestyle intervention (ILS), or placebo. Read More

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http://dx.doi.org/10.7326/M18-1605DOI Listing

Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

Aging (Albany NY) 2019 Apr;11(7):2045-2070

See ACKNOWLEDGMENTS AND FUNDING.

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. Read More

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http://dx.doi.org/10.18632/aging.101900DOI Listing

Association between child marriage and utilization of maternal health care services in India: Evidence from a nationally representative cross-sectional survey.

Midwifery 2019 Apr 18;75:66-71. Epub 2019 Apr 18.

Department of Geography, University of Gour Banga, Malda 732103, West Bengal, India.

Objective: In an effort to improve utilization of maternal health care services, age at marriage of girls has gain very little attention by the policy maker and programmer. Studies have indicated that child marriage has serious negative consequences on maternal health. Moreover, there is a paucity of research on explaining the links between child marriage and maternal health care utilization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02666138193009
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http://dx.doi.org/10.1016/j.midw.2019.04.007DOI Listing
April 2019
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Carbon black-induced detrimental effect on osteoblasts at low concentrations: Remarkably compromised differentiation without significant cytotoxicity.

Ecotoxicol Environ Saf 2019 Apr 19;178:211-220. Epub 2019 Apr 19.

Beijing Jishuitan Hospital, Peking University Health Science Center, Beijing, 100035, PR China. Electronic address:

Due to similar aerodynamic and micro-nano sized properties between airborne particles and synthetic nanoparticles, a large number of studies have been conducted using carbon-based particles, such as carbon black (CB), carbon nanotubes and graphite, in order to achieve deeper understandings of their adverse effects on human health. It has been reported that particulate matters can aggravate morbidity of patients suffering from bone and joint diseases, e.g. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.029DOI Listing

miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma.

Mol Ther Nucleic Acids 2019 Mar 13;16:391-406. Epub 2019 Mar 13.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli," 80138 Naples, Italy; IRGS, Biogem, Molecular and Precision Oncology Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy. Electronic address:

miR-125b, ubiquitously expressed and frequently dysregulated in several tumors, has gained special interest in the field of cancer research, displaying either oncogenic or oncosuppressor potential based on tumor type. We have previously demonstrated its tumor-suppressive role in multiple myeloma (MM), but the analysis of molecular mechanisms needs additional investigation. The purpose of this study was to explore the effects of miR-125b and its chemically modified analogs in modulating cell viability and cancer-associated molecular pathways, also focusing on the functional aspects of stress adaptation (autophagy and senescence), as well as programmed cell death (apoptosis). Read More

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http://dx.doi.org/10.1016/j.omtn.2019.02.023DOI Listing

CIDR estrous synchronization in the Arabian Oryx (Oryx leucoryx).

Theriogenology 2019 Apr 15;132:113-117. Epub 2019 Apr 15.

Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University, Saudi Arabia.

In Jordan, the Arabian Oryx (Oryx leucoryx) is considered among the most important wild ungulates. The Arabian Oryx is listed as vulnerable species according to the International Union for Conservation of Nature (IUCN). Based on author's knowledge, estrus synchronization in the Arabian Oryx has never been investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093691X193009
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http://dx.doi.org/10.1016/j.theriogenology.2019.04.017DOI Listing
April 2019
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Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities.

Eur J Med Chem 2019 Apr 16;173:282-293. Epub 2019 Apr 16.

Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address:

Two series of andrographolide derivatives with introduction of amide moiety into ring A by Beckmann rearrangement were synthesized. In series 1, the ring A was converted to caprolactam, and an amide moiety was linked to C-19 of ring A in series 2. Among them, compound 8h exhibited obvious inhibition on HK2 enzyme activity (IC = 9. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234193032
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http://dx.doi.org/10.1016/j.ejmech.2019.04.022DOI Listing
April 2019
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Design, synthesis and biological evaluation of novel neuchromenin analogues as potential antifungal agents.

Eur J Med Chem 2019 Apr 14;173:228-239. Epub 2019 Apr 14.

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi Province, China. Electronic address:

In continuation of our program to discover new potential antifungal agents, thirty-two neuchromenin analogues were synthesized and characterized by the spectroscopic analysis. By using the mycelium growth rate method, the target compounds were evaluated systematically for antifungal activities in vitro against six plant pathogenic fungi, and structure-activity relationships (SAR) were derived. Compounds 6b-c, and 6l showed obvious inhibition activity on each of the fungi at 50 μg/mL. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.029DOI Listing

Mechanical modeling of pimple growth.

J Mech Behav Biomed Mater 2019 Apr 16;95:191-195. Epub 2019 Apr 16.

Advanced Materials for Energy and Environment, Department of Earth and Environmental Engineering, Columbia University, New York, NY, 10027, USA; School of Chemical Engineering, Northwest University, Xi'an, 710069, PR China.

Pimple is one of the most common skin diseases for humans, whose growth cause pain yet the corresponding mechanical analysis is lacking. A finite element model is developed to quantify the deformation field with the expansion of follicle, and then the mechanical stimulus is related to the sensation of pain during the development of pimple. Parametric studies show the dependence of mechanical stimulus and pain level on the pimple-surrounded structures, follicle depth and mechanical properties of the epidermis. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.04.017DOI Listing

Untargeted LC/MS-based metabolic phenotyping (metabonomics/metabolomics): The state of the art.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 8;1117:136-147. Epub 2019 Apr 8.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College, Exhibition Road, South Kensington, London SW7 2AZ, UK. Electronic address:

Liquid chromatography (LC) hyphenated to mass spectrometry is currently the most widely used means of determining metabolic phenotypes via both untargeted and targeted analysis. At present a range of analytical separations, including reversed-phase, hydrophilic interaction and ion-pair LC are employed to maximise metabolome coverage with ultra (high) performance liquid chromatography (UHPLC) increasingly displacing conventional high performance liquid chromatography because of the need for short analysis times and high peak capacity in such applications. However, it is widely recognized that these methodologies do not entirely solve the problems facing researchers trying to perform comprehensive metabolic phenotyping and in addition to these "routine" approaches there are continuing investigations of alternative separation methods including 2-dimensional/multi column approaches. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.009DOI Listing

In-situ creating elastic lattice OO bonds over semicrystalline yellow TiO nanoparticles for significantly enhanced photocatalytic H production.

J Hazard Mater 2019 Apr 12;374:287-295. Epub 2019 Apr 12.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, P. R. China. Electronic address:

Atomic defects (e.g., Ti, oxygen vacancies) have been intenstively investigated for modifying TiO in order to reach visible light active photocatalytic H production. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.04.035DOI Listing

"Closed-Incision Negative-Pressure Therapy Efficacy in Abdominal Wall Reconstruction in High-Risk Patients: A Meta-Analysis".

J Surg Res 2019 Apr 19;241:63-71. Epub 2019 Apr 19.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Obesity is a known risk factor for surgical complications. Closed-incision negative-pressure therapy (ciNPT) has been used anecdotally in high-risk patients to prevent wound complications and infection. This meta-analysis aims to evaluate the efficacy of ciNPT in reducing the incidence of wound complications and infection in abdominal wall reconstruction. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.033DOI Listing

Inconsistency in Opioid Prescribing Practices After Pediatric Ambulatory Hernia Surgery.

J Surg Res 2019 Apr 19;241:57-62. Epub 2019 Apr 19.

Cohen Children's Medical Center, Northwell Health System, Division of Pediatric Surgery, New York, New York; Zucker School of Medicine at Hofstra/Northwell Health System, Department of Surgery, Manhasset, New York.

Introduction: Nonmedical opioid use is a major public health problem. There is little standardization in opioid-prescribing practices for pediatric ambulatory surgery, which can result in patients being prescribed large quantities of opioids. We have evaluated the variability in postoperative pain medication given to pediatric patients following routine ambulatory pediatric surgical procedures. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.043DOI Listing

A selectivity study of benzenesulfonamide derivatives on human carbonic anhydrase II/IX by 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation.

Comput Biol Chem 2019 Apr 4;80:234-243. Epub 2019 Apr 4.

School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China; Chongqing Key Laboratory of Targeted Drug Screening and Activity Evaluation, Chongqing, 400054, China; Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing, 400054, China. Electronic address:

Nowadays, different approaches have been pursued with the intent to develop sulfonamide-like carbonic anhydrase inhibitors that possess better selectivity profiles toward the different human isoforms of the enzyme. Here, we used conventional 3D-QSAR methods, including comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA), and Topomer CoMFA, to construct three-dimensional quantitative structure-activity relationship (3D-QSAR) models for benzenesulfonamide derivatives as human carbonic anhydrase (hCA) II/IX inhibitors. The theoretical models had good reliability (R>0. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.03.005DOI Listing

Play for Success: An intervention to boost object exploration in infants from low-income households.

Infant Behav Dev 2019 Apr 19;55:112-122. Epub 2019 Apr 19.

Whitman College, United States. Electronic address:

Infants from low-income households typically spend less time exploring objects and use less mature strategies when they do explore compared to their higher-income peers (e.g., Clearfield et al. Read More

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http://dx.doi.org/10.1016/j.infbeh.2019.03.001DOI Listing

Differential associations of locus of control with anxiety, depression and life-events: A five-wave, nine-year study to test stability and change.

J Affect Disord 2019 Apr 11;253:26-34. Epub 2019 Apr 11.

University of Groningen, University Medical Center Groningen (UMCG), Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotional regulation (ICPE), Groningen, the Netherlands.

Background: The locus of control (LOC) construct has been associated with onset, course, and severity of anxiety and depression. We investigated the stability of LOC, the bidirectional relationships between LOC and symptom severity of anxiety and depression over nine years, and the influence of intermediate positive and negative life-events on these associations.

Methods: Data came from five assessment waves over nine years of 2052 subjects with an anxiety or depressive disorder or healthy controls. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.005DOI Listing

Inhibitory effects of sildenafil and tadalafil on inflammation, oxidative stress and nitrosative stress in animal model of bronchial asthma.

Pharmacol Rep 2019 Feb 15;71(3):517-521. Epub 2019 Feb 15.

Vallabhbhai Patel Chest Institute, New Delhi, India.

Background: Cyclic neucleotides are involved in many cellular functions including smooth muscle relaxation, inflammation, and signal transduction. Sildenafil and tadalafil are phosphodiesterase-5 (PDE-5) inhibitors which prevent the degradation of cyclic neucleotide i.e. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.008DOI Listing
February 2019

Urban and agriculturally influenced water contribute differently to the spread of antibiotic resistance genes in a mega-city river network.

Water Res 2019 Apr 12;158:11-21. Epub 2019 Apr 12.

Key Laboratory for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Science, East China Normal University, Shanghai, 200241, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China; Joint Research Institute for New Energy and the Environment, East China Normal University and Colorado State University, Shanghai, 200062, China. Electronic address:

The widespread of water borne antibiotic resistance genes (ARGs) represents a growing threat to the health of millions of people. Our study detected the relative abundances of 10 ARG subtypes in the Shanghai river network, where the major ARG components were strB, sul1, and ermB. These ARGs were significantly enriched by the combined sewage, tail water from urban wastewater treatment plant and runoff from agricultural areas, which reached the Suzhou (SZ), Dianpu (DP), and Huangpu (HP) River, respectively (one-way ANOVA, P < 0. Read More

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http://dx.doi.org/10.1016/j.watres.2019.03.010DOI Listing

In vitro susceptibility of Plasmodium falciparum isolates from the China-Myanmar border area to artemisinins and correlation with K13 mutations.

Int J Parasitol Drugs Drug Resist 2019 Apr 10;10:20-27. Epub 2019 Apr 10.

Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, Yunnan Province, 650500, China. Electronic address:

Mutations in the Kelch domain of the K13 gene (PF3D7_1343700) were previously associated with artemisinin resistance in Plasmodium falciparum. This study followed the dynamics of the K13 polymorphisms in P. falciparum parasites from the China-Myanmar border area obtained in 2007-2016, and their in vitro sensitivities to artesunate (AS) and dihydroartemisinin (DHA). Read More

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http://dx.doi.org/10.1016/j.ijpddr.2019.04.002DOI Listing

CRAC channels and disease - From human CRAC channelopathies and animal models to novel drugs.

Authors:
Stefan Feske

Cell Calcium 2019 Mar 11;80:112-116. Epub 2019 Mar 11.

Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA. Electronic address:

Ca release-activated Ca (CRAC) channels are intimately linked with health and disease. The gene encoding the CRAC channel, ORAI1, was discovered in part by genetic analysis of patients with abolished CRAC channel function. And patients with autosomal recessive loss-of-function (LOF) mutations in ORAI1 and its activator stromal interaction molecule 1 (STIM1) that abolish CRAC channel function and store-operated Ca entry (SOCE) define essential functions of CRAC channels in health and disease. Read More

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http://dx.doi.org/10.1016/j.ceca.2019.03.004DOI Listing

The value of manure - Manure as co-product in life cycle assessment.

J Environ Manage 2019 Apr 19;241:293-304. Epub 2019 Apr 19.

Innovation Center for U.S. Dairy, USA.

Livestock production is important for food security, nutrition, and landscape maintenance, but it is associated with several environmental impacts. To assess the risk and benefits arising from livestock production, transparent and robust indicators are required, such as those offered by life cycle assessment. A central question in such approaches is how environmental burden is allocated to livestock products and to manure that is re-used for agricultural production. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.03.059DOI Listing

The effect of frontoparietal paired associative stimulation on decision-making and working memory.

Cortex 2019 Mar 28;117:266-276. Epub 2019 Mar 28.

Department of Psychiatry, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.

Previous single-site neurostimulation experiments have unsuccessfully attempted to shift decision-making away from habitual control, a fast, inflexible cognitive strategy, towards goal-directed control, a flexible, though computationally expensive strategy. We employed a dual-target neurostimulation approach in 30 healthy participants, using cortico-cortical paired associative stimulation (ccPAS) to target two key nodes: lateral prefrontal cortex (LPFC) and intraparietal sulcus (IPS), to test whether decision-making can be artificially shifted from habitual toward goal-directed control. Participants received three active stimulations, delivered at least six days apart (each involving 100 paired pulses over the IPS and LPFC, varying the interstimulus interval): two interventional, time-relevant ccPAS (10 msec interval) and one control, non-time-relevant ccPAS (100 msec interval). Read More

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http://dx.doi.org/10.1016/j.cortex.2019.03.015DOI Listing

Lung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 515.33 TERT-CLPTM1L Region.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03756, USA. Electronic address:

Introduction: Inherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
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http://dx.doi.org/10.1016/j.jtho.2019.04.008DOI Listing
April 2019
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Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection.

Microbes Infect 2019 Apr 19. Epub 2019 Apr 19.

Illawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, New South Wales, Australia. Electronic address:

Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA mice compared to AlbPLG1 mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12864579193005
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http://dx.doi.org/10.1016/j.micinf.2019.04.004DOI Listing
April 2019
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Stathmin regulates the proliferation and odontoblastic/ osteogenic differentiation of human dental pulp stem cells through Wnt/β-catenin signaling pathway.

J Proteomics 2019 Apr 19. Epub 2019 Apr 19.

Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China; College of Stomatology, Southern Medical University, Guangzhou, PR China. Electronic address:

Osteogenic/ odontoblastic differentiation of human dental pulp stem cells (hDPSCs) is a key factor in tooth and pulp regeneration, but its mechanism still remains unknown. The purpose of this research is to look into the mechanism by which Stathmin affects the proliferation and odontoblastic/ osteogenic differentiation of hDPSCs, and whether the Wnt/β- catenin is related to this regulation. First, the Stathmin expression was inhibited by lentiviral vector, after that the transcriptome sequencing technology was used to screen the differentially expressed genes, Wnt5a which related to the regulation of Wnt/β-catenin was regulated. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.04.014DOI Listing

[Laparoscopic lateral approach for hysterectomy: a new technique for voluminous uterus (with a video)].

Gynecol Obstet Fertil Senol 2019 Apr 19. Epub 2019 Apr 19.

Centre Hospitalier Simone Veil, 14 rue de Saint Prix, 95600 Eaubonne, France.

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http://dx.doi.org/10.1016/j.gofs.2019.04.013DOI Listing

Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Boston Children's Hospital, Boston, MA. Electronic address:

Background & Aims: Fecal microbiota transplantation (FMT) is commonly used to treat Clostridium difficile infection (CDI). CDI is an increasing cause of diarrheal illness in pediatric patients, but the effects of FMT have not been well studied in children. We performed a multi-center retrospective cohort study of pediatric and young adult patients to evaluate the efficacy, safety, and factors associated with a successful FMT for the treatment of CDI. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.037DOI Listing

Should We Divide Crohn's Disease Into Ileum-dominant and Isolated Colonic Diseases?

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

University of California San Diego, La Jolla CA.

Crohn's disease (CD) is an inflammatory bowel disease, which can involve any region of the gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it predominately involves the ileum with or without colonic involvement. Isolated colonic CD was first described in 1960 and since then the phenotypic classification of CD has evolved to stratify patients into isolated ileal, ileocolonic, or isolated colonic involvement. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.040DOI Listing
April 2019
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Surgical Treatment of Lipomatosis of Nerve: A Systematic Review.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurologic Surgery, University of Utah, Salt Lake City, Utah 84132.

Background: Lipomatosis of nerve (LN) is one part of spectrum of adipose lesions of nerve. Nerve-territory overgrowth is present in approximately 62% of cases. Given the wide variability in published reports, there is substantial need to understand the results of surgical treatment and outcomes in this disorder. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193110
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http://dx.doi.org/10.1016/j.wneu.2019.04.110DOI Listing
April 2019
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Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress.

Prostaglandins Other Lipid Mediat 2019 Apr 19. Epub 2019 Apr 19.

Institute for Food Toxicology, University of Veterinary Medicine Hannover, Hannover, Germany; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany. Electronic address:

In mammals, epoxy-polyunsaturated fatty acids (epoxy-PUFA) are enzymatically formed from naturally occurring all-cis PUFA by cytochrome P450 monooxygenases leading to the generation of cis-epoxy-PUFA (mixture of R,S- and S,R-enantiomers). In addition, also non-enzymatic chemical peroxidation gives rise to epoxy-PUFA leading to both, cis- and trans-epoxy-PUFA (mixture of R,R- and S,S-enantiomers). Here, we investigated for the first time trans-epoxy-PUFA and the trans/cis-epoxy-PUFA ratio as potential new biomarker of lipid peroxidation. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.04.004DOI Listing

Two paternal mosaicism of mutation in ELANE causing severe congenital neutropenia exhibit normal neutrophil morphology and ROS production.

Clin Immunol 2019 Apr 19. Epub 2019 Apr 19.

Chong Qing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Division of Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Electronic address:

Severe congenital neutropenia caused by ELANE gene mutation is a rare disease. To date, only four families were reported with mosaicism. Here we examined the morphology and function of granulocytes isolated from two patients and their mosaic fathers. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.008DOI Listing

Metabolic and epigenetic reprogramming in the arsenic-induced cancer stem cells.

Semin Cancer Biol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, 48201, USA. Electronic address:

At present, the belief that genetic mutations control every aspect of tumorigenesis is still very popular. Even for the highly debated "bad luck" theory of cancers, it ascertained that random mutation of genes during the self-renewal of somatic stem cells is responsible for cancer initiation. Logically, most of the new therapeutic strategies so far, from molecular targeting to precision medicine or personalized medicine, are genome-obsessed and focused on identifying and targeting these mutated genes. Read More

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http://dx.doi.org/10.1016/j.semcancer.2019.04.003DOI Listing

A Learning Loop Model of Collaborative Decision Making in Chronic Illness.

Acad Pediatr 2019 Apr 19. Epub 2019 Apr 19.

Center for Community Health Integration, Department of Family Medicine & Community Health, Department of Population & Quantitative Health Sciences, Department of Sociology, Case Western Reserve University, Cleveland, Ohio 44106. Electronic address:

Shared decision-making is a core attribute of quality healthcare that has proved challenging to implement and assess in pediatric practice. Current models of shared decision-making are limited, including their capacity: to incorporate multiple stakeholders; to integrate downstream effects of subacute or minor decisions; and to account for the context(s) in which such decisions are being made and enacted. Based on a review of literature from organizational psychology, cognitive sciences, business, and medicine, we propose an iterative decision-making model of care planning, and identify targets at several levels of influence warranting measurement in future studies. Read More

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http://dx.doi.org/10.1016/j.acap.2019.04.006DOI Listing

Origin and evolution of core components responsible for monitoring light environment changes during plant terrestrialization.

Mol Plant 2019 Apr 19. Epub 2019 Apr 19.

School of Advanced Agriculture Sciences and School of Life Sciences, State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing 100871, China. Electronic address:

Light serves as the source of energy as well as information signals for photosynthetic plants. During evolution, plants have acquired the ability to monitor environmental light radiation and adjust their developmental patterns to optimally utilize light energy for photosynthesis. The mechanisms of light perception and signal transduction have been comprehensively studied in the past decades, mostly in a few model plants, including Arabidopsis thaliana. Read More

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http://dx.doi.org/10.1016/j.molp.2019.04.006DOI Listing

A Pilot Metabolomics Study of Tuberculosis Immune Reconstitution Inflammatory Syndrome.

Int J Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

Mycobacterial Research Laboratories, Colorado State University, Fort Collins, CO, USA; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. Electronic address:

Background: Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS.

Methods: Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.015DOI Listing

Multicenter analysis of endovascular aortic arch in situ stent graft fenestrations for aortic arch pathologies.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Vascular and Endovascular Surgery, University Hospital Regensburg, Germany.

Objective: In situ fenestration of aortic stent grafts for treatment of aortic arch aneurysms is a new option for endovascular aortic arch repair. So far, only few reports have shown perioperative and short term results of in situ fenestrations for aortic arch diseases. We present the multicenter experience with the (aortic archin situfenestration) technique documented in the AARCHIF registry for treatment of aortic arch aneurysms or localized type A aortic dissections and analyzed perioperative outcome and midterm follow up. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.02.005DOI Listing

Perioperative and follow-up results of Carotid Artery Stenting and Carotid Endarterectomy in Patients with carotid near-occlusion.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Institute of Vascular Surgery, Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: Comparing perioperative and follow-up results of Carotid Artery Stenting (CAS) and Carotid Endarterectomy (CEA) in Patients with carotid near-occlusion (NO).

Methods: A retrospective analysis was conducted from January 2012 to June 2017 on consecutive NO patients in our center. Perioperative complications, recurrence rate of ischemic stroke, restenosis rate and mortality in follow-up were compared between CAS group and CEA group. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.01.019DOI Listing

Hybrid Repair of an Intrathoracic Bi-Lobed Subclavian Artery Aneurysm.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Vascular Surgery, Englewood Hospital, Englewood New Jersey, USA.

Intrathoracic subclavian artery aneurysms are extremely rare, <1% of all aneurysms. The formation of these aneurysms is often multifactorial, with the most common contributing factor being atherosclerosis. This case report describes a right subclavian artery aneurysm that required a surgical hybrid approach. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.12.106DOI Listing

Review:Using the Idea, Development, Exploration, Assessment, Long-term study Framework for Devices (IDEAL-D) to better understand the evolution of evidence surrounding fenestrated abdominal aortic endovascular grafts.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Section of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire. Electronic address:

The use of fenestrated endovascular devices for repair of complex aortic aneurysms has increased to nearly 5,000 implantations annually in Medicare patients in the United States in recent years. Given that nearly all aspects of treatment for minimally invasive aortic intervention rely on medical devices to better care for patients with vascular disease, a clear understanding how new and innovative technology evolves over the life cycle of a medical device is an essential skill set for cardiovascular physicians. Despite the need for this understanding, there is no standard framework upon which cardiovascular physicians, regulators, and patients can rely to better understand the evolution of evidence from product inception through adoption and long-term effectiveness evaluation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08905096193023
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http://dx.doi.org/10.1016/j.avsg.2019.02.010DOI Listing
April 2019
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Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: A redox signaling perspective.

Nitric Oxide 2019 Apr 19. Epub 2019 Apr 19.

New York University School of Medicine, New York, NY, USA.

Cancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammatory tumor microenvironment play an essential role in directly influencing intercellular and intracellular signaling. These reactive species originating in the cancer cell or its microenvironment, mediate the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET). Read More

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http://dx.doi.org/10.1016/j.niox.2019.04.009DOI Listing

The effect of Xiang-Sha-Liu-Jun-Zi tang (XSLJZT) on irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial.

J Ethnopharmacol 2019 Apr 19:111889. Epub 2019 Apr 19.

Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan; Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 40402, Taiwan; Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan. Electronic address:

Background: Irritable bowel syndrome (IBS) is characterized by chronic, recurrent abdominal pain or abdominal discomfort and changes in defecation habits. Xiang-Sha-Liu-Jun-Zi tang (XSLJZT) is a traditional Chinese medical formula that can modulate gastrointestinal disturbance.

Purpose: To investigate the therapeutic effect of XSLJZT on IBS. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111889DOI Listing

The Quality Chasm Between Administrative Coding and Accurate Phenotyping of Heart Failure.

J Card Fail 2019 Apr 19. Epub 2019 Apr 19.

Section of Cardiovascular Medicine, New Haven, CT; Center for Outcomes Research and Evaluation (CORE) at Yale University School of Medicine, New Haven, CT. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2019.04.010DOI Listing

Large Urban Center Improves Out-of-Hospital Cardiac Arrest Survival.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Emergency Medicine, University of Illinois at Chicago. Electronic address:

Background: Large cities pose unique challenges that limit the effectiveness of system improvement interventions. Successful implementation of integrated cardiac resuscitation systems of care can serve as a model for other urban centers.

Methods: This was a retrospective analysis of prospectively collected data of adult cases of non-traumatic cardiac arrest who received treatment by Chicago Fire Department EMS from September 1, 2013 through December 31, 2016. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.019DOI Listing

The first complete mitochondrial genome of a cyclophorid land snail, with implications for architaenioglossan relationships (Mollusca, Caenogastropoda, Cyclophoroidea).

Int J Biol Macromol 2019 Apr 19. Epub 2019 Apr 19.

School of Life Sciences, Nanchang University, Nanchang 330031, China. Electronic address:

Herein, we described the complete mitochondrial genome ('mitogenome') of the Chinese land snail Cyclophorus martensianus, which is the first published mitogenome for the caenogastropod family Cyclophoridae. This mitogenome is 15,308 bp long consisting of 37 genes: 13 protein-coding genes (PCG's), 22 tRNA genes and two rRNA genes. The A + T content (69. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.138DOI Listing

Untargeted LC-MS-based metabonomics revealed that aristolochic acid I induces testicular toxicity by inhibiting amino acids metabolism, glucose metabolism, β-oxidation of fatty acids and the TCA cycle in male mice.

Toxicol Appl Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Chinese Academy of Inspection and Quarantine, Institute of Chemicals Safety, Beijing, China. Electronic address:

As the main toxic component of aristolochic acid, aristolochic acid I (AAI) is primarily found in Aristolochiaceae plants such as Aristolochia, Aristolochia fangchi and Caulis aristolochiae manshuriensis. AAI has been proven to be carcinogenic, mutagenic and nephrotoxic. Although the role of AAI in testicular toxicity has been reported, its mechanism of action is unknown. Read More

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http://dx.doi.org/10.1016/j.taap.2019.04.014DOI Listing
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