178 results match your criteria Nevus Comedonicus


Giant nevus comedonicus of the entire lower left limb protecting from the associated bullous pemphigoid: A hypothetical role of NEK9 mutation?

J Dermatol 2021 May 17. Epub 2021 May 17.

Section of Dermatology, DiSSal, San Martino Polyclinic Hospital IRCCS, University of Genova, Genova, Italy.

We present the case of a 92-year-old woman, with bullous pemphigoid (BP) and a concomitant nevus comedonicus (NC) presenting as an asymptomatic, linear lesion of the entire lower left limb, formed by multiple comedones. Dermoscopy of the NC and histopathology confirmed the clinical and dermoscopic suspect of giant congenital nevus comedonicus. The two entities presented no overlap. Read More

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Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series.

J Am Acad Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Faculty of Medicine, Institute of Human Genetics, Medical Center - University of Freiburg, Freiburg, Germany. Electronic address:

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Nevus comedonicus syndrome: A systematic review of the literature.

Authors:
Daniele Torchia

Pediatr Dermatol 2021 Mar 22;38(2):359-363. Epub 2021 Jan 22.

Department of Dermatology, James Paget University Hospital, Great Yarmouth, UK.

Nevus comedonicus (NC) syndrome is a condition first identified in 1978. The cause of NC syndrome has been recently proven to be a gain-of-function, mosaic postzygotic mutation of the NEK9 gene. A systematic review of the literature retrieved 43 well-established cases of NC syndrome reported so far. Read More

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Dermoscopy of late-onset nevus comedonicus.

An Bras Dermatol 2020 Nov - Dec;95(6):773-775. Epub 2020 Sep 14.

Dermatology Unit, Galliera Hospital, Genova, Italy; Surgical Pathology, Galliera Hospital, Genova, Italy.

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Bilateral nevus comedonicus of the eyelids: An unusual cause of ptosis and ectropion.

Am J Ophthalmol Case Rep 2020 Dec 29;20:100907. Epub 2020 Aug 29.

Department of Ophthalmology, Ain Shams University, Cairo, Egypt.

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December 2020

Nevus Comedonicus Suppurativa: A Report of a Novel Entity.

J Clin Aesthet Dermatol 2020 Jun 1;13(6):36-39. Epub 2020 Jun 1.

Drs. Sharma, Sahu, Dayal, and Yadav are with the Department of Dermatology at the Pandit B.D. Sharma Postgraduate Institute of Medical Sciences in Rohtak, Haryana, India.

Nevus comedonicus and hidradenitis suppurativa (HS) are disorders of the pilosebaceous unit sharing a similar pathogenesis of follicular occlusion. To our knowledge, less than 10 cases of HS-like lesions complicating nevus comedonicus have been reported. We describe a six-year-old female child with congenital linear nevus comedonicus in the left axilla and groin, complicated by recurrent HS-like lesions in the two years prior to presenting to our clinic. Read More

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Punctate porokeratosis-pruritic and hyperkeratotic papules on the palms and feet.

Proc (Bayl Univ Med Cent) 2020 Jul 24;33(3):415-416. Epub 2020 Apr 24.

Division of Dermatology, Baylor University Medical CenterDallasTexas.

Porokeratosis is an uncommon cutaneous condition with multiple clinical variants that is defined by round patches with a raised, fine scaling border. Punctate porokeratosis is a rare variant of porokeratosis that is characterized by elevated, seed-like lesions of the palms and soles. While variants of porokeratosis may be associated with an increased risk of squamous cell carcinoma within the lesion, punctate porokeratosis does not increase the risk of squamous cell carcinoma. Read More

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Improvement of nevus comedonicus after repeated microneedling.

JAAD Case Rep 2020 Feb 30;6(2):152-153. Epub 2020 Jan 30.

Texas Tech University Health Sciences Center, Department of Dermatology, Lubbock, Texas.

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February 2020

Further delineation of the phenotypic spectrum of nevus comedonicus syndrome to include congenital pulmonary airway malformation of the lung and aneurysm.

Am J Med Genet A 2020 04 21;182(4):746-754. Epub 2020 Jan 21.

Division of Pediatrics, Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Nevus comedonicus syndrome (NCS) is a rare epidermal nevus syndrome characterized by ocular, skeletal, and central nervous system anomalies. We present a 23-month-old boy with a history of a congenital pulmonary airway malformation (CPAM) of the lung and a congenital cataract who developed progressive linear and curvilinear plaques of dilated follicular openings with keratin plugs (comedones) on parts of his scalp, face, and body consistent with nevus comedonicus. MRI of the brain demonstrated an aneurysm of the right internal carotid artery. Read More

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Nevus Comedonicus With Acne Vulgaris and Obesity.

Dermatol Pract Concept 2020 31;10(1):e2020006. Epub 2019 Dec 31.

Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Italy.

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December 2019

Bilateral nevus comedonicus of the eyelids: An unusual cause of ptosis and ectropion.

Am J Ophthalmol Case Rep 2020 Mar 17;17:100579. Epub 2019 Dec 17.

Department of Ophthalmology, Centre Hospitalier Universitaire de Martinique, Martinique, French West Indies, France.

Purpose: Nevus comedonicus is a rare developmental abnormality of the infundibulum of the hair follicle.

Observation: We report here an unusual case of bilateral extensive nevus comedonicus of the eyelids complicated by bilateral ptosis and ectropion of the lower eyelids. Blepharoplasty was performed on both upper eyelids. Read More

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An unexpected coexistence of two epidermal naevi on the scalp: Naevus comedonicus and naevus sebaceous.

Australas J Dermatol 2020 Feb 19;61(1):e142-e143. Epub 2019 Aug 19.

Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey.

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February 2020

Successful treatment of late-onset nevus comedonicus with Er:YAG laser.

J Cosmet Dermatol 2020 Apr 22;19(4):863-865. Epub 2019 Jul 22.

Department of Pathology, Faculty of Medicine, Bahçeşehir University, Istanbul, Turkey.

Nevus comedonicus, a rare congenital hamartoma of the pilosebaceous unit, is characterized by keratotic plugging. It usually occurs after birth and during early childhood. It rarely appears in adulthood. Read More

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An Unusual Birthmark on the Scalp: A Quiz.

Acta Derm Venereol 2019 Jul;99(9):846-847

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China.

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Late onset nevus comedonicus of scalp: a rare site for an uncommon condition.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Department of Dermatology, Venereology and Leprosy, Dr. Ram Manohar Lohia Post Graduate Institute of Medical Education and Research, New Delhi.

Nevus comedonicus is an uncommon hamartoma of the pilosebaceous unit characterized by keratin filled pits simulating open comedones. It may present at birth but is more commonly seen during childhood or adolescence. The most commonly affected sites are the face, neck, trunk, and arms with a few reported cases on palms, genitalia, and scalp. Read More

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A Microneedling Fractional Radiofrequency Device for the Treatment of Nevus Comedonicus.

Dermatol Surg 2020 01;46(1):148-150

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.

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January 2020

Dermoscopy of nevus comedonicus.

North Clin Istanb 2019 28;6(4):401-402. Epub 2018 Nov 28.

Department of Dermatology, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.

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November 2018

Late-Onset Nevus Comedonicus With Follicular Epidermolytic Hyperkeratosis-Case Report and Review of the Literature.

Am J Dermatopathol 2019 Jun;41(6):453-455

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Nevus comedonicus is a rare cutaneous follicular hamartoma, characterized by the clustering of papules with firm, blackened horny buffers. It is usually present at birth or during childhood, although few cases of late-onset disease have been described. We present a case of postmenopausal-onset nevus comedonicus in a 55-year-old white woman without relevant medical history. Read More

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Mutation and expression of ABCA12 in keratosis pilaris and nevus comedonicus.

Mol Med Rep 2018 Sep 31;18(3):3153-3158. Epub 2018 Jul 31.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Keratosis pilaris (KP) and nevus comedonicus (NC) are congenital keratinized dermatoses; however, the exact etiology of these two diseases is unclear. The objective of the present study was to identify the disease‑causing genes and their association with functional alterations in the development of KP and NC. Peripheral blood samples of one KP family, two NC families and 100 unrelated healthy controls were collected. Read More

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September 2018

Congenital nevus comedonicus complicated by a hidradenitis suppurativa-like lesion: Report of a childhood case.

Pediatr Dermatol 2018 Sep 27;35(5):e298-e299. Epub 2018 Jun 27.

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Nevus comedonicus is a rare, benign hamartoma of the pilosebaceous unit that may be isolated or part of the nevus comedonicus syndrome. Although rare in children, complication by hidradenitis suppurativa-like lesions has been described. We present a report of a 9-year-old girl in whom surgical excision was curative, with a review of the relevant literature. Read More

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September 2018

Biologic therapy: a boon for hidradenitis suppurativa-like lesions complicating naevus comedonicus in a prepubertal child.

Clin Exp Dermatol 2019 04 11;44(3):322-324. Epub 2018 Jun 11.

Dr V. K. Jain Skin Center, Rohtak, Haryana, India.

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Extensive Nevus Comedonicus, Complicated with Recurrent Abscesses, Successfully Treated with Surgical Resurfacing.

J Cutan Aesthet Surg 2018 Jan-Mar;11(1):33-37

Department of Plastic Surgery, St Johns' Medical College and Hospital, Bengaluru, Karnataka, India.

Nevus comedonicus is a rare epidermal abnormality of the pilosebaceous unit, which is congenital in most patients but may also appear early in childhood. It may be localized or have an extensive involvement, the latter showing a unilateral predominance with only a few cases presenting bilaterally. Extensive nevus comedonicus can be associated with musculoskeletal defects, eye and neurological involvement, which constitutes nevus comedonicus syndrome. Read More

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Nevus Comedonicus on Scalp: An Unusual Presentation.

Int J Trichology 2018 Jan-Feb;10(1):37-39

Department of Dermatology, Venereology and Leprology, Pt B. D. Sharma University of Health Sciences, Rohtak, Haryana, India.

Nevus comedonicus (NC) is a rare developmental anomaly of follicular infundibulum plugged with keratinous material that resembles comedo-like lesions. Frequently affected sites are face, neck, trunk, and upper arm. Few cases have been described on palms, soles, scalp, and genitalia. Read More

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February 2018

Nevus Comedonicus: Case Report.

Case Rep Dermatol 2017 Sep-Dec;9(3):184-189. Epub 2017 Oct 4.

Sector of Dermatology and Post-Graduation Course, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Nevus comedonicus is a rare cutaneous anomaly, characterized by the clustering of papules with firm, blackened horny buffers. It in general has a zosteriform pattern and affects both genders equally. In some patients, there is formation of cysts, abscesses, and fistulas, aggravating its psychosocial impact. Read More

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October 2017

Epidermal nevus syndromes: New insights into whorls and swirls.

Pediatr Dermatol 2018 Jan 16;35(1):21-29. Epub 2017 Oct 16.

Department of Dermatology, University of California, San Francisco, Santa Rosa, CA, USA.

Knowledge of the molecular underpinnings of many epidermal nevi and epidermal nevus syndrome has expanded rapidly in recent years. In this review and update on epidermal nevus syndrome, we will cover recent genetic discoveries involving epidermal nevi, including nevus sebaceus, keratinocytic epidermal nevus, nevus comedonicus, congenital hemidysplasia with ichthyosiform nevus and limb defects syndrome, phakomatosis pigmentokeratotica, Becker's nevus, porokeratotic adnexal ostial nevus, inflammatory linear verrucous epidermal nevi, and cutaneous-skeletal hypophosphatemia syndrome. We will discuss how newly defined mutations relate to the biology reflected in the cutaneous patterns seen in these mosaic disorders and how new molecular data has informed our understanding of these diseases and shaped management decisions. Read More

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January 2018

Dermoscopy of Nevus Comedonicus.

Indian Dermatol Online J 2017 Sep-Oct;8(5):388-389

Department of Dermatology and Venereology, Pramukhswami Medical College, Karamsad, Gujarat, India.

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October 2017

Isotretinoin and Surgical Extraction for Adult-Onset Nevus Comedonicus.

Skinmed 2017;15(4):309-310. Epub 2017 Aug 1.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY;

We present a case of postmenopausal-onset nevus comedonicus in a 58-year-old white woman with no relevant medical history. Two years before presentation, the patient had had a solitary red nodule, measuring 3.8 cm wide, on the mid lateral region of her left thigh. Read More

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