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    154 results match your criteria Nevus Comedonicus

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    Nevus Comedonicus on Scalp: An Unusual Presentation.
    Int J Trichology 2018 Jan-Feb;10(1):37-39
    Department of Dermatology, Venereology and Leprology, Pt B. D. Sharma University of Health Sciences, Rohtak, Haryana, India.
    Nevus comedonicus (NC) is a rare developmental anomaly of follicular infundibulum plugged with keratinous material that resembles comedo-like lesions. Frequently affected sites are face, neck, trunk, and upper arm. Few cases have been described on palms, soles, scalp, and genitalia. Read More

    Nevus Comedonicus: Case Report.
    Case Rep Dermatol 2017 Sep-Dec;9(3):184-189. Epub 2017 Oct 4.
    Sector of Dermatology and Post-Graduation Course, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Nevus comedonicus is a rare cutaneous anomaly, characterized by the clustering of papules with firm, blackened horny buffers. It in general has a zosteriform pattern and affects both genders equally. In some patients, there is formation of cysts, abscesses, and fistulas, aggravating its psychosocial impact. Read More

    Epidermal nevus syndromes: New insights into whorls and swirls.
    Pediatr Dermatol 2018 Jan 16;35(1):21-29. Epub 2017 Oct 16.
    Department of Dermatology, University of California, San Francisco, Santa Rosa, CA, USA.
    Knowledge of the molecular underpinnings of many epidermal nevi and epidermal nevus syndrome has expanded rapidly in recent years. In this review and update on epidermal nevus syndrome, we will cover recent genetic discoveries involving epidermal nevi, including nevus sebaceus, keratinocytic epidermal nevus, nevus comedonicus, congenital hemidysplasia with ichthyosiform nevus and limb defects syndrome, phakomatosis pigmentokeratotica, Becker's nevus, porokeratotic adnexal ostial nevus, inflammatory linear verrucous epidermal nevi, and cutaneous-skeletal hypophosphatemia syndrome. We will discuss how newly defined mutations relate to the biology reflected in the cutaneous patterns seen in these mosaic disorders and how new molecular data has informed our understanding of these diseases and shaped management decisions. Read More

    Isotretinoin and Surgical Extraction for Adult-Onset Nevus Comedonicus.
    Skinmed 2017 1;15(4):309-310. Epub 2017 Aug 1.
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY;
    We present a case of postmenopausal-onset nevus comedonicus in a 58-year-old white woman with no relevant medical history. Two years before presentation, the patient had had a solitary red nodule, measuring 3.8 cm wide, on the mid lateral region of her left thigh. Read More

    Squamous cell carcinoma arising in a multiple verrucous epidermal nevus.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):166-168
    Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
    Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely associated with malignant neoplasms. The majority of squamous cell carcinoma develop in linear or multiple epidermal nevus and rarely in solitary epidermal nevus. In general, the prognosis is favorable. Read More

    Generalized Comedones, Acne, and Hidradenitis Suppurativa in a Patient with an Missense Mutation.
    Front Med (Lausanne) 2017 28;4:16. Epub 2017 Feb 28.
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland; King's College, St John's Institute of Dermatology, London, UK.
    Mutations in the fibroblast growth factor-receptor gene 2 () gene have been implicated in numerous diseases, including nevus comedonicus (NC) and naevoid acne that have somatic missense mutations in in the affected tissue. A patient presented in our department with unusual, innumerable large comedones throughout his back reminiscient of NC, as well as multifocal hidradenitis suppurativa and acne. Topical and systemic treatments were unsuccessful. Read More

    Ultrapulse carbon dioxide laser treatment for bilateral facial nevus comedonicus: A case report.
    Dermatol Ther 2017 May 15;30(3). Epub 2017 Feb 15.
    Department of Dermatology, Chinese PLA 89th Hospital, Weifang, Shandong, China.
    Nevus comedonicus (NC), a rare skin ailment with an aggregation of dilated follicular orifices filled with keratinous material, is difficult to treat. Several drugs have been assessed for the treatment of NC, but with limited success. Surgery requires much experience and the recurrence rate is high. Read More

    Birt-Hogg-Dubé Syndrome Presenting as a Nevus Comedonicus-Like Lesion in an 8-Year-Old Boy.
    Pediatr Dermatol 2016 Sep 28;33(5):e294-5. Epub 2016 Jul 28.
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
    Birt-Hogg-Dubé syndrome is an uncommon genodermatosis characterized by hair follicle hamartomas and an increased risk of pneumothorax and renal cell carcinoma. Recognition of cutaneous manifestations is essential because it allows for early screening and management of systemic complications. We present the case of an 8-year-old boy with a recently described cystic and comedonal variant of the classic fibrofolliculoma, which had been present since birth. Read More

    Somatic Mutations in NEK9 Cause Nevus Comedonicus.
    Am J Hum Genet 2016 May;98(5):1030-1037
    Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT 06510, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:
    Acne vulgaris (AV) affects most adolescents, and of those affected, moderate to severe disease occurs in 20%. Comedones, follicular plugs consisting of desquamated keratinocytes and sebum, are central to its pathogenesis. Despite high heritability in first-degree relatives, AV genetic determinants remain incompletely understood. Read More

    Extensive unilateral nevus comedonicus without genetic abnormality.
    Dermatol Online J 2016 Sep 15;22(9). Epub 2016 Sep 15.
    Apollonia University. Nicolina Medical Center, Dept.of Dermatology , Iasi, Romania.
    Nevus comedonicus is considered a genodermatosis characterized by the presence of multiple groups of dilated pilosebaceous orifices filled with black keratin plugs, with sharply unilateral distribution mostly on the face, neck, trunk, upper arms. Lesions can appear at any age, frequently before the age of 10 years, but they are usually present at birth. We present a 2. Read More

    Epidermal nevus syndromes.
    Handb Clin Neurol 2015 ;132:291-316
    Departments of Dermatology and Community and Family Medicine, University of California San Francisco, Santa Rosa, CA, USA. Electronic address:
    The term epidermal nevus syndrome (ENS) has been used to describe the association of epidermal hamartomas and extracutaneous abnormalities. Although many continue to use the term "ENS," it is now understood that this is not one disease, but rather a heterogeneous group with distinct genetic profiles defined by a common cutaneous phenotype: the presence of epidermal and adnexal hamartomas that are associated with other organ system involvement. One commonality is that epidermal nevi often follow the lines of Blaschko and it appears the more widespread the cutaneous manifestations, the greater the risk for extracutaneous manifestations. Read More

    Nevus Comedonicus Syndrome.
    Indian J Dermatol 2015 Jul-Aug;60(4):421
    Department of Dermatology and Sexually Transmitted Diseases, Lady Hardinge Medical College and Suchita Kriplani Hospital, Shaheed Bhagat Singh Marg, Delhi - 110 001, India.
    A case of nevus comedonicus syndrome with atypical cutaneous presentation (widespread involvement without any particular pattern, midline lesions involving lower abdomen and involvement of bilateral pinna), and some unusual skeletal (adduction deformity involving bilateral metatarsal along with medial deviation at the level of tarsometatarsal joint), central nervous system (agenesis of corpus callosum with a interhemispheric cyst), visceral (pancreatic cyst) and neurological manifestations have been illustrated. Read More

    Nevus comedonicus on scalp: a rare site.
    Indian J Dermatol 2015 Jan-Feb;60(1):105
    Department of Pathology, Sri Dharmasthala Manjunatheshwara, SDM College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
    Nevus comedonicus is rare hamartoma of the pilosebaceous unit. Curiously the scalp is rarely involved. Here we are reporting 33-year-old male presenting with nevus comedonicus arranged linearly on the scalp. Read More

    Nevus comedonicus: a case series.
    Pediatr Dermatol 2015 Mar-Apr;32(2):216-9. Epub 2014 Dec 29.
    Hospital Ramos Mejía, Buenos Aires, Argentina.
    Twelve previously unreported cases of nevus comedonicus are presented. Characteristic closely grouped dilated follicular openings with horny plugs that mimic comedones led to the diagnosis. One patient had nevus comedonicus syndrome and there were cases with atypical locations and unusual complications of this condition. Read More

    Two Concurrent Facial Epidermal Nevi without Systemic Abnormalities: Nevus Sebaceus and Nevus Comedonicus.
    Ann Dermatol 2014 Aug 31;26(4):501-4. Epub 2014 Jul 31.
    Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea.
    Epidermal nevi (EN) are hamartomatous lesions derived from epidermal components originating from pluripotent cell mutations. They have been categorized according to their predominant component. The existence of >2 types of EN concurrently within a single area or within contiguous areas has been rarely reported. Read More

    Inflammatory nevus comedonicus with epidermoid cyst.
    Indian J Dermatol 2014 Jul;59(4):422
    Department of Pathology, University College of Medical Sciences and GTB Hospital (University of Delhi), Delhi, India.
    We present here a case of inflammatory nevus comedonicus (NC) in a young male distributed along the Blaschko's lines only over the right lower limb and associated with epidermoid cysts. The case was unique in terms of isolated involvement of lower limb and the rare association of epidermoid cyst. Read More

    Extensive nevus comedonicus involving the palm: questionable role of the pilosebaceous unit in pathogenesis.
    Pediatr Dermatol 2014 Jul-Aug;31(4):e96-9. Epub 2014 May 29.
    Department of Skin and Sexually Transmitted Diseases, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    A 10-year-old boy had multiple grouped pits with black plugs arranged along the lines of Blaschko on his left chest, arm, and palm. Involvement of the palms is rarely reported in the literature. Recent reports have described mosaic acneiform conditions that could share pathogenetic mechanisms with nevus comedonicus. Read More

    Nevus comedonicus of the scalp.
    Skinmed 2014 Jan-Feb;12(1):59-60
    A 10-year-old boy presented to us with a localized patch of hair loss on the scalp, first noticed by his mother a few months after birth. The lesion had shown very little increase in size since that time. There was a history of occasional redness and discharge from the lesion, which used to be controlled with topical applications. Read More

    Nevus comedonicus in oral-facial-digital syndrome type 1: a new finding or overlapping syndromes?
    Pediatr Dermatol 2014 Mar-Apr;31(2):e48-51. Epub 2014 Feb 11.
    University of Texas Southwestern Medical School, Dallas, Texas.
    We report a patient with oral-facial-digital syndrome type 1 (OFDS1) who exhibited features overlapping those of nevus comedonicus syndrome, an unusual presentation that may potentially represent a new variant of OFDS1. OFDS1 and nevus comedonicus syndrome represent two rare syndromes with numerous overlapping features that have yet to be described in relation to one another. The features present in our patient led us to propose the possibility of a new variant of OFDS1 in which nevus comedonicus represents a cutaneous manifestation of the syndrome. Read More

    Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus.
    Case Rep Dermatol 2013 5;5(3):272-82. Epub 2013 Oct 5.
    Rumailah Hospital, Doha, Qatar.
    A malignant transformation is known to occur in many nevi such as a sebaceous nevus or a basal cell nevus, but a verrucous epidermal nevus has only rarely been associated with neoplastic changes. Keratoacanthoma, multifocal papillary apocrine adenoma, multiple malignant eccrine poroma, basal cell carcinoma and cutaneous squamous cell carcinoma (CSCC) have all been reported to develop from a verrucous epidermal nevus. CSCC has also been reported to arise from other nevoid lesions like a nevus comedonicus, porokeratosis, a sebaceous nevus, an oral sponge nevus and an ichthyosiform nevus with CHILD syndrome. Read More

    Acneiform eruptions.
    Clin Dermatol 2014 Jan-Feb;32(1):24-34
    Department of Dermatology, Andreas Syggros Hospital, University of Athens, Athens, Greece. Electronic address:
    Is it acne or is it not? When this question arises, we can presume that we have crossed the boundaries of "acneiform eruptions" of the face. Although acne may be considered a condition fairly easy to diagnose, it is not rare for the practicing dermatologist or the general physician to wonder when faced with an acneiform eruption before establishing a diagnosis. In this review, we address facial acneiform eruptions in children and in adults, including perioral dermatitis, granulomatous periorificial dermatitis, nevus comedonicus, acne cosmetica, rosacea, demodicosis, folliculitis, acneiform presentation of cutaneous lymphomas, and drug-induced [epidermal growth factor receptor (EGFR) inhibitors, steroids, etc. Read More

    Dermoscopy on nevus comedonicus: a case report and review of the literature.
    Postepy Dermatol Alergol 2013 Aug 27;30(4):252-4. Epub 2013 Aug 27.
    The Center for Cancer Prevention and Treatment, Katowice, Poland. Head: Beata Wydmańska.
    Nevus comedonicus (NC) is a very rare, benign hamartoma characterised by the occurrence of dilated, comedo-like openings, typically on the face, neck, upper arms, chest or abdomen. In uncertain cases, histopathological examination confirms the diagnosis. The authors suggest dermoscopy as a rapid and useful method of initial diagnosis of nevus comedonicus based upon its distinctive dermoscopic features. Read More

    Carmakila: An effective management by kshara karma.
    J Ayurveda Integr Med 2013 Jul;4(3):181-3
    Department of Shalya Tantra, KLE University, Shri. B.M. Kankanawadi Ayurveda Mahavidyalaya, Shahapur, Belgaum, Karnataka, India.
    Epidermal nevi are hamartomas that are characterized by hyperplasia of epidermis and adnexal structures. These nevi may be classified into a number of distinct variants, which are based on clinical morphology, extent of involvement, and the predominant epidermal structure in the lesion. Variants include verrucous epidermal nevus, nevus sebaceous, nevus comedonicus, eccrine nevus, apocrine nevus, Becker's nevus, and white sponge nevus. Read More

    Bilateral nevus comedonicus syndrome.
    Yonago Acta Med 2013 Jun 12;56(2):59-61. Epub 2013 Jul 12.
    Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan ; †Department of Dermatology, National Hospital Organization Kyushu Medical Center, Fukuoka 810-0065, Japan.
    Nevus comedonicus is an uncommon skin abnormality characterized by an aggregation of dilated follicular orifices filled with keratinous material. Nevus comedonicus is occasionally complicated with other conditions including cataracts, skeletal defects, central nervous system abnormalities or other extra-cutaneous diseases (nevus comedonicus syndrome). Although most cases of nevus comedonicus occur unilaterally on the face, neck and chest, the lesions occasionally show a bilateral distribution (bilateral nevus comedonicus). Read More

    Nevus comedonicus: an updated review.
    Dermatol Ther (Heidelb) 2013 Jun 25;3(1):33-40. Epub 2013 May 25.
    Policlinic for Dermatology and Venerology, Saint Kliment Ohridski University, University Hospital Lozenetz, Sofia, Bulgaria.
    The intention of this review on nevus comedonicus (NC) is to update on clinical features, pathogenesis, and therapy. NC is a rare epidermal nevus type. It is part of the nevus comedonicus syndrome, a neurocutaneous disorder with ocular, skeletal, and central nervous symptoms. Read More

    Bilateral nevus comedonicus of the eyelids.
    Ophthal Plast Reconstr Surg 2013 Jul-Aug;29(4):e95-8
    David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts 02114, USA.
    Nevus comedonicus is a rare developmental abnormality of the infundibulum of the hair follicle. It is usually unilateral and commonly presents at birth or during childhood. A rare case of late-onset, bilateral nevus comedonicus of the eyelids is reported. Read More

    Keratoacanthoma arising in nevus comedonicus.
    Dermatol Online J 2012 Jul 15;18(7). Epub 2012 Jul 15.
    Department of Dermatology, Avicenne University Hospital, Rabat, Morrocco.
    Nevus comedonicus is a benign hamartoma of the pilosebaceous unit and is considered as a rare subtype of epidermal nevus. It was first described in 1895. It manifests as a group of closely dilated follicular openings with dark keratin plugs resembling comedones. Read More

    Multiple large cysts arising from nevus comedonicus.
    Arch Plast Surg 2012 Jan 15;39(1):63-6. Epub 2012 Jan 15.
    Department of Plastic and Reconstructive Surgery, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea.
    Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of the mesodermal part of the pilosebaceous gland. In most cases of nevus comedonicus, an acne-like skin condition develops. Repeated inflammation can cause a morphological change to the cyst, papule, to abscess. Read More

    Inflammatory linear verrucous epidermal nevus syndrome with its polymorphic presentation - A rare case report.
    Contemp Clin Dent 2012 Jan;3(1):119-22
    Department of Oral Medicine and Radiology, K. D. Dental College and Hospital, Mathura, Uttar Pradesh, India.
    Epidermal nevi are hamartomatous lesions that are typically present at birth, but can occur anytime during childhood and may rarely appear in adulthood. An estimated one-third of individuals with epidermal nevi have involvement of other organ systems; hence, this condition is considered to be an epidermal nevus syndrome. There are four distinct epidermal nevus syndromes recognizable by the different types of associated epithelial nevi: linear sebaceous nevi, linear nevus comedonicus, linear epidermal nevus, and inflammatory linear verrucous epidermal nevus (ILVEN). Read More

    Segmental acne versus mosaic conditions with acne lesions.
    Dermatology 2012 27;224(1):10-4. Epub 2012 Mar 27.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.
    Acne rarely presents in segmental patterns, which are encountered only in cutaneous mosaicism. We report herein two cases of segmentally arranged acne and systematically review the literature on the topic. Beside already known mosaic conditions which may show primary lesions typical of acne, i. Read More

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